DYX1C1

Summary

Gene Symbol: DYX1C1
Description: dyslexia susceptibility 1 candidate 1
Alias: CILD25, DNAAF4, DYX1, DYXC1, EKN1, dynein, axonemal, assembly factor 4, dyslexia susceptibility 1 candidate gene 1 protein
Species: human

Top Publications

  1. ncbi DYX1C1 functions in neuronal migration in developing neocortex
    Y Wang
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06268, USA
    Neuroscience 143:515-22. 2006
  2. doi Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
    Satu Massinen
    Department of Medical Genetics, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland
    Hum Mol Genet 18:2802-12. 2009
  3. ncbi A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia
    Cecilia Marino
    Department of Child Psychiatry, Scientific Institute Eugenio Medea, via Don L Monza 20, 23842 Bosisio Parini, Italy
    Eur J Hum Genet 13:491-9. 2005
  4. pmc The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia
    Isabel Tapia-Paez
    Department of Biosciences and Nutrition, 141 57 Huddinge, Karolinska Institute, Stockholm, Sweden
    FASEB J 22:3001-9. 2008
  5. pmc Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children
    Cadmon K P Lim
    Croucher Laboratory for Human Genomics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Behav Brain Funct 7:16. 2011
  6. doi A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer
    Yuxin Chen
    Lab of Reproductive Medicine, Department of Cell Biology and Medical Genetics, Nanjing Medical University, 210029 Nanjing, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 135:1265-76. 2009
  7. doi Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker
    Yun Ji Kim
    Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, 609 735, Republic of Korea
    J Cancer Res Clin Oncol 135:265-70. 2009
  8. pmc A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain
    Mikko Taipale
    Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 100:11553-8. 2003
  9. doi Further evidence for DYX1C1 as a susceptibility factor for dyslexia
    Faten Dahdouh
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 19:59-63. 2009
  10. ncbi Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia
    Zoran Brkanac
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98198 7720, USA
    Am J Med Genet B Neuropsychiatr Genet 144:556-60. 2007

Research Grants

  1. Molecular Diagnosis of Dyslexia
    Seiyu Hosono; Fiscal Year: 2007
  2. Discovery of the 6p21.3 Reading Disability Gene
    Jeffrey R Gruen; Fiscal Year: 2010
  3. Genetic Interactions in Developmental Dyslexia
    Lauren McGrath; Fiscal Year: 2008

Scientific Experts

  • Simon E Fisher
  • C Marino
  • Caitlin E Szalkowski
  • Gustaf Rosin
  • Idor Svensson
  • Silvia Paracchini
  • G Poelmans
  • T C Bates
  • Lauren McGrath
  • Myriam Peyrard Janvid
  • Glenn Rosen
  • S Jamadar
  • B S Shastry
  • Roberta Buonincontri
  • Tero Ylisaukko-Oja
  • Juha Kere
  • Isabel Tapia-Paez
  • Jeffrey R Gruen
  • Kristiina Tammimies
  • Heidi Anthoni
  • Myriam Peyrard-Janvid
  • Hans Matsson
  • Seiyu Hosono
  • Marco Zucchelli
  • Shyamala K Venkatesh
  • Gerd Schulte-Körne
  • K G Wigg
  • Jaana Nopola-Hemmi
  • Heikki Lyytinen
  • Yun Ji Kim
  • Johannes Schumacher
  • Andreas Warnke
  • Satu Massinen
  • Jan Ake Gustafsson
  • Bertram Muller-Myhsok
  • Markus M Nothen
  • Christopher J Gibson
  • Y Feng
  • C L Barr
  • Päivi Onkamo
  • T S Scerri
  • Zoran Brkanac
  • Mikko Taipale
  • Aarti Tarkar
  • William T Adler
  • C Tran
  • S Mascheretti
  • Gayathri Chandrasekar
  • Prakash Padakannaya
  • Nicola H Chapman
  • Anand Siddaiah
  • Nallur B Ramachandra
  • Li Zou
  • Yuping Zhang
  • Ramona A Hoh
  • Fahimeh Darki
  • Yun Jing Zhao
  • Alexander E Ivliev
  • Joseph J LoTurco
  • Paavo H T Leppanen
  • D F Newbury
  • Cadmon K P Lim
  • T A Currier
  • Eero Castren
  • Marie Estelle Hokkanen
  • Heui Soo Kim
  • Lisa A Gabel
  • Dae Soo Kim
  • Jae Won Huh
  • Per Hoffmann
  • Tracey L Petryshen
  • Faten Dahdouh
  • Yuxin Chen
  • M W Lovett
  • A M Galaburda
  • Bruce F Pennington
  • T D Cate-Carter
  • Shelley D Smith
  • Richard K Olson
  • Pushpa Saviour
  • J F Stein
  • Helmut Remschmidt
  • A P Monaco
  • Steven W Threlkeld
  • Y Wang
  • R Tannock
  • Virginia W Berninger
  • Wendy H Raskind
  • Ellen M Wijsman
  • Haiying Meng

Detail Information

Publications67

  1. ncbi DYX1C1 functions in neuronal migration in developing neocortex
    Y Wang
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06268, USA
    Neuroscience 143:515-22. 2006
    ..report that in utero RNA interference against the rat homolog of another candidate dyslexia susceptibility gene, DYX1C1, disrupts neuronal migration in developing neocortex...
  2. doi Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia
    Satu Massinen
    Department of Medical Genetics, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland
    Hum Mol Genet 18:2802-12. 2009
    ..One of the susceptibility genes, DYX1C1, has been implicated in neuronal migration, but little is known about its interactions and functions...
  3. ncbi A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia
    Cecilia Marino
    Department of Child Psychiatry, Scientific Institute Eugenio Medea, via Don L Monza 20, 23842 Bosisio Parini, Italy
    Eur J Hum Genet 13:491-9. 2005
    We applied a family-based association approach to investigate the role of the DYX1C1 gene on chromosome 15q as a candidate gene for developmental dyslexia (DD) to 158 families containing at least one dyslexic child...
  4. pmc The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia
    Isabel Tapia-Paez
    Department of Biosciences and Nutrition, 141 57 Huddinge, Karolinska Institute, Stockholm, Sweden
    FASEB J 22:3001-9. 2008
    b>DYX1C1 was first identified as a candidate gene for dyslexia susceptibility, and its role in controlling neuronal migration during embryogenesis and effect on learning in rodents have been verified...
  5. pmc Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children
    Cadmon K P Lim
    Croucher Laboratory for Human Genomics, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Behav Brain Funct 7:16. 2011
    ..Studies of western populations have suggested that DYX1C1 is a candidate gene for dyslexia...
  6. doi A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer
    Yuxin Chen
    Lab of Reproductive Medicine, Department of Cell Biology and Medical Genetics, Nanjing Medical University, 210029 Nanjing, Jiangsu, People s Republic of China
    J Cancer Res Clin Oncol 135:1265-76. 2009
    ..repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia...
  7. doi Molecular characterization of the DYX1C1 gene and its application as a cancer biomarker
    Yun Ji Kim
    Division of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, 609 735, Republic of Korea
    J Cancer Res Clin Oncol 135:265-70. 2009
    b>DYX1C1 has three alternatively spliced transcripts. Therefore, we expect that alternative transcripts of DYX1C1 are used as a biomarker to detect specific cancer.
  8. pmc A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain
    Mikko Taipale
    Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 100:11553-8. 2003
    ..We report here the characterization of a gene, DYX1C1 near the DYX1 locus in chromosome 15q21, that is disrupted by a translocation t(2;15)(q11;q21) segregating ..
  9. doi Further evidence for DYX1C1 as a susceptibility factor for dyslexia
    Faten Dahdouh
    Institute of Human Genetics, Life and Brain Center, University of Bonn, Bonn, Germany
    Psychiatr Genet 19:59-63. 2009
    Dyslexia-susceptibility-1-candidate-1 (DYX1C1) was the first gene associated with dyslexia. Since the original report of 2003, eight replication attempts have been published reporting discordant results...
  10. ncbi Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia
    Zoran Brkanac
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98198 7720, USA
    Am J Med Genet B Neuropsychiatr Genet 144:556-60. 2007
    ..of several polymorphisms, candidate genes responsible for the observed linkage signal have been proposed-DYX1C1 for 15q21, and KIAA0319 and DCDC2 for 6p22.2...
  11. ncbi Association of short-term memory with a variant within DYX1C1 in developmental dyslexia
    C Marino
    Scientific Institute Eugenio Medea, Department of Child Psychiatry, Bosisio Parini, Italy
    Genes Brain Behav 6:640-6. 2007
    ..After the identification of the DYX1C1 gene as a potential candidate for DD, several independent association studies reported controversial results...
  12. ncbi No support for association between dyslexia susceptibility 1 candidate 1 and developmental dyslexia
    N A Cope
    Mol Psychiatry 10:237-8. 2005
  13. ncbi Support for EKN1 as the susceptibility locus for dyslexia on 15q21
    K G Wigg
    Department of Psychiatry, Cell and Molecular Division, The Toronto Western Hospital, University Health Network, Toronto, Ontario M5T 2S8, Canada
    Mol Psychiatry 9:1111-21. 2004
    Dyslexia has been linked to a number of chromosomal regions including 15q. Recently a gene, EKN1, with unknown function in the linked region, was identified via a translocation breakpoint...
  14. ncbi Family-based association study of DYX1C1 variants in autism
    Tero Ylisaukko-Oja
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    Eur J Hum Genet 13:127-30. 2005
    b>DYX1C1: was recently identified as a candidate gene for developmental dyslexia, which is characterized by an unexpected difficulty in learning to read and write despite adequate intelligence, motivation, and education...
  15. pmc Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK
    T S Scerri
    J Med Genet 41:853-7. 2004
  16. doi Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation
    T C Bates
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 15:1190-6. 2010
    The status of DYX1C1 (C15q21.3) as a susceptibility gene for dyslexia is unclear. We report the association of this gene with reading and spelling ability in a sample of adolescent twins and their siblings...
  17. ncbi No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy
    Giulia Bellini
    Chair of Child Neuropsychiatry, Department of Pediatrics, Second University of Naples, Naples, Italy
    J Mol Neurosci 27:311-4. 2005
    Recently, DYX1C1, a candidate gene for developmental dyslexia, encoding a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain, has been characterized through a translocation breakpoint in a Finnish family...
  18. doi Association of SNPs of DYX1C1 with developmental dyslexia in an Indian population
    Shyamala K Venkatesh
    aGenetics and Genomics Laboratory, Department of Studies in Zoology bDepartment of Studies in Psychology, University of Mysore, Manasagangotri, Mysore, Karnataka
    Psychiatr Genet 24:10-20. 2014
    b>DYX1C1 has been identified as a susceptible candidate gene for developmental dyslexia (DD); studies in various populations have yielded inconclusive results and the causal allele is unknown in the Indian population...
  19. ncbi Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q
    Nicola H Chapman
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Med Genet B Neuropsychiatr Genet 131:67-75. 2004
    ..falls between a region implicated in a recent genome screen for attention-deficit/hyperactivity disorder, and DYX1C1, a candidate gene for dyslexia...
  20. ncbi TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort
    Haiying Meng
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, 464 Congress Avenue, New Haven, CT 06520 8081, USA
    Hum Genet 118:87-90. 2005
    A candidate gene, EKN1, was recently described in a cohort from Finland for the dyslexia locus on chromosome 15q, DYX1. This report described a (2;15) (q11;21) translocation disrupting EKN1 that cosegregated with dyslexia in a two-..
  21. pmc Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy
    Caitlin E Szalkowski
    Department of Psychology Behavioral Neuroscience, University of Connecticut, Storrs, Conn 06269, USA
    Dev Neurosci 35:50-68. 2013
    ..and neuroanatomical effects of embryonic knockdown of the candidate dyslexia susceptibility gene (CDSG) homolog Dyx1c1 through RNA interference (RNAi) in rats...
  22. pmc Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319
    Caitlin E Szalkowski
    Department of Psychology Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, Unit 1020, Storrs, CT 06269, USA
    Int J Dev Neurosci 30:293-302. 2012
    ..animal models and embryonic RNA interference (RNAi) has shown that a subset of the candidate dyslexia risk genes--DYX1C1, ROBO1, DCDC2, KIAA0319--regulate critical parameters of neocortical development, such as neuronal migration...
  23. pmc The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer
    Gustaf Rosin
    Department of Biosciences and Nutrition, Novum, and Science for Life Laboratory, Karolinska Institutet, Hälsovägen 7, Huddinge, Sweden
    BMC Cancer 12:79. 2012
    The dyslexia candidate gene, DYX1C1, shown to regulate and interact with estrogen receptors and involved in the regulation of neuronal migration, has recently been proposed as a putative cancer biomarker...
  24. doi A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1
    C Tran
    Genetics and Development Division, Toronto Western Research Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 162:146-56. 2013
    ..Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at ..
  25. pmc DYX1C1 is required for axonemal dynein assembly and ciliary motility
    Aarti Tarkar
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA
    Nat Genet 45:995-1003. 2013
    ..Thus, we propose that DYX1C1 is a newly identified dynein axonemal assembly factor (DNAAF4).
  26. pmc Position of neocortical neurons transfected at different gestational ages with shRNA targeted against candidate dyslexia susceptibility genes
    William T Adler
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65179. 2013
    ..2 and DYX1C1 on Chr 15q21...
  27. doi The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation
    Kristiina Tammimies
    Department of Biosciences and Nutrition, Karolinska Institutet, SE 14183 Huddinge, Sweden
    Mol Endocrinol 26:619-29. 2012
    ..and estrogen signaling, when we studied the functional interactions between the dyslexia candidate protein DYX1C1 and the estrogen receptors α (ERα) and β (ERβ)...
  28. pmc Association of the DYX1C1 dyslexia susceptibility gene with orthography in the Chinese population
    Yuping Zhang
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    PLoS ONE 7:e42969. 2012
    Several independent studies have supported the association of DYX1C1 with dyslexia, but its role in general reading development remains unclear...
  29. pmc The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language
    Heidi Anthoni
    Department of Medical Genetics, Biomedicum, University of Helsinki, 00014, Helsinki, Finland
    Behav Genet 42:509-27. 2012
    ..CYP19A1 expression in human brain correlated with the expression of dyslexia susceptibility genes such as DYX1C1 and ROBO1...
  30. ncbi [Molecular genetics of functional articulation disorder in children]
    Yun Jing Zhao
    Department of Developmental Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China
    Zhongguo Dang Dai Er Ke Za Zhi 14:316-20. 2012
    ..ROBO1 gene in 3p12.3, ZNF280D gene, TCF12 gene, EKN1 gene in 15q21, and KIAA0319 gene in 6p22 have been candidate genes for the study of functional articulation disorder...
  31. pmc Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease
    Ramona A Hoh
    Department of Biology, Stanford University, Stanford, CA, USA
    PLoS ONE 7:e52166. 2012
    ..We found that three genes associated with human disease states, Mdm1, Mlf1, and Dyx1c1, are upregulated during ciliogenesis and localize to centrioles and cilia...
  32. doi An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes
    S Mascheretti
    The Academic Centre for the Study of Behavioural Plasticity, Vita Salute San Raffaele University, Milan 20132, Italy
    Genes Brain Behav 12:47-55. 2013
    ..The presence of GxE effects were investigated for the DYX1C1, DCDC2, KIAA0319 and ROBO1 genes, and for seven specified environmental moderators in 165 nuclear families in ..
  33. pmc Exploring the transcriptome of ciliated cells using in silico dissection of human tissues
    Alexander E Ivliev
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    PLoS ONE 7:e35618. 2012
    ..The novel findings included a set of genes (DCDC2, DYX1C1, KIAA0319) related to a neurological disease dyslexia suggesting their potential involvement in ciliary functions...
  34. doi Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure
    Fahimeh Darki
    Neuroscience Department, Karolinska Institutet, Stockholm, Sweden
    Biol Psychiatry 72:671-6. 2012
    ..Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown...
  35. pmc The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function
    Gayathri Chandrasekar
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 8:e63123. 2013
    b>DYX1C1, a susceptibility gene for dyslexia, encodes a tetratricopeptide repeat domain containing protein that has been implicated in neuronal migration in rodent models. The developmental role of this gene remains unexplored...
  36. doi Molecular networks of DYX1C1 gene show connection to neuronal migration genes and cytoskeletal proteins
    Kristiina Tammimies
    Center for Biosciences, Department of Biosciences and Nutrition, Novum, Karolinska Institutet, Huddinge, Sweden
    Biol Psychiatry 73:583-90. 2013
    The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene has recently been associated with dyslexia and reading scores in several population samples...
  37. doi Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: an integrated meta-analysis
    Li Zou
    Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, China
    Am J Med Genet B Neuropsychiatr Genet 159:970-6. 2012
    b>DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth...
  38. ncbi [Genetics of dyslexia]
    Gerd Schulte-Körne
    1 Klinik für Kinder und Jugendpsychiatrie, Psychosomatik und Psychotherapie, Klinikum der Universitat Munchen, Pettenkoferstrasse 8a, DE 80336 München
    Z Kinder Jugendpsychiatr Psychother 34:435-44. 2006
    ..Recently, four candidate genes, DCDC2, KIAA0319, ROBO1 and DYX1C1 were identified by systematic association analyses...
  39. doi A cohort of balanced reciprocal translocations associated with dyslexia: identification of two putative candidate genes at DYX1
    Roberta Buonincontri
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Behav Genet 41:125-33. 2011
    ..one of the breakpoints concurred (at the cytogenetic level) with either a known dyslexia linkage region--at 15q21 (DYX1), 2p13 (DYX3) and 1p36 (DYX8)--or an unpublished linkage region at 19q13...
  40. pmc The human lexinome: genes of language and reading
    Christopher J Gibson
    Department of Pediatrics, Yale Child Health Research Center, Yale University School of Medicine, New Haven, CT 06520 8081, USA
    J Commun Disord 41:409-20. 2008
    ..Further genetic studies have identified four dyslexia genes within the DYX loci: DYX1C1 on 15q, KIAA0319 and DCDC2 on 6p22, and ROBO1 on 13q...
  41. ncbi The genetic lexicon of dyslexia
    Silvia Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Annu Rev Genomics Hum Genet 8:57-79. 2007
    ..advances with the identification of four candidate genes located within three of these linked chromosome regions: DYX1C1 on chromosome 15, ROBO1 on chromosome 3, and KIAA0319 and DCDC2 on chromosome 6...
  42. ncbi A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia
    Heidi Anthoni
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    Hum Mol Genet 16:667-77. 2007
    ..and C2ORF3, but not FLJ13391, were also correlated with the four dyslexia candidate genes identified so far (DYX1C1, ROBO1, DCDC2 and KIAA0319)...
  43. pmc Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1
    Steven W Threlkeld
    Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 806 Babbidge Road, Storrs, CT 06269 1020, USA
    Brain Res Bull 71:508-14. 2007
    ..Three of these, DYX1C1, DCDC2, and KIAA0319, have been shown by in utero RNAi to play a role in neuronal migration in developing ..
  44. pmc Disruption of neuronal migration by RNAi of Dyx1c1 results in neocortical and hippocampal malformations
    Glenn D Rosen
    Dyslexia Research Laboratory and Charles A Dana Research Institute, Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cereb Cortex 17:2562-72. 2007
    ..RNA interference (RNAi) of Dyx1c1, a candidate dyslexia susceptibility gene, disrupts neuronal migration in developing embryonic neocortex...
  45. pmc Progress towards a cellular neurobiology of reading disability
    Lisa A Gabel
    Department of Psychology, Lafayette College, Easton, PA, USA
    Neurobiol Dis 38:173-80. 2010
    ..recent findings that revealed neuroanatomic anomalies in RD, studies that identified 3 candidate genes (KIAA0319, DYX1C1, and DCDC2), and compelling evidence that potentially link the function of candidate genes to the neuroanatomic ..
  46. ncbi Developmental dyslexia: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 52:104-9. 2007
    ..Recently, four candidate genes (KIAA 0319, DYX1C1, DCDC2 and ROBO1) are shown to be associated with dyslexia...
  47. pmc A new gene (DYX3) for dyslexia is located on chromosome 2
    T Fagerheim
    Department of Medical Genetics, University Hospital of Tromsø, Norway
    J Med Genet 36:664-9. 1999
    ..Possible localisations of genes for dyslexia have been reported on chromosomes 15 (DYX1), 6p21.3-23 (DYX2), and 1p over the last 15 years. Only the localisation to 6p21...
  48. ncbi Breakthroughs in the search for dyslexia candidate genes
    Lauren M McGrath
    University of Denver, Department of Psychology, Frontier Hall, 2155 S Race St, Denver, CO 80208, USA
    Trends Mol Med 12:333-41. 2006
    Four genes have recently been proposed as candidates for dyslexia: dyslexia susceptibility 1 candidate 1 (DYX1C1), roundabout Drosophila homolog 1 (ROBO1), doublecortin domain-containing protein 2 (DCDC2) and KIAA0319...
  49. ncbi Genes, cognition and dyslexia: learning to read the genome
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Cogn Sci 10:250-7. 2006
    ..In this article, we provide an accessible overview of four prominent examples--DYX1C1, KIAA0319, DCDC2 and ROBO1--and discuss their relevance for cognition...
  50. ncbi Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones
    Shigetsugu Hatakeyama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Genes Cells 9:533-48. 2004
    ..proteins tested were found to interact with molecular chaperones or cochaperones, including Hsp90, Hsp70, DnaJc7, EKN1, CRN, and VCP...
  51. ncbi Fine mapping of the 2p11 dyslexia locus and exclusion of TACR1 as a candidate gene
    Myriam Peyrard-Janvid
    Department of Biosciences at Novum, Karolinska Institutet, 141 57, Huddinge, Sweden
    Hum Genet 114:510-6. 2004
    ..e. DYX1-3 and DYX5-6, have been clearly identified from the human genome. To date, DYX1C1 is the only dyslexia candidate gene cloned...
  52. doi Identification of novel dyslexia candidate genes through the analysis of a chromosomal deletion
    G Poelmans
    Department of Clinical Genetics, Academic Hospital Maastricht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:140-7. 2009
    ..Within two of these loci, DYX1C1 (15q21) and ROBO1 (3p12) have recently been proposed as dyslexia candidate genes through the molecular analysis of ..
  53. doi Association of ADHD and the Protogenin gene in the chromosome 15q21.3 reading disabilities linkage region
    K G Wigg
    Genetics and Development Division, The Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Genes Brain Behav 7:877-86. 2008
    ..Based on a translocation finding and association to two specific alleles, the candidate gene, DYX1C1, has been proposed as the susceptibility gene for RD in 15q...
  54. pmc Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population
    S Paracchini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
    Genes Brain Behav 10:158-65. 2011
    ..markers, previously reported to be associated with dyslexia, located within the MRPL19/C2ORF3, KIAA0319, DCDC2 and DYX1C1 genes in a sample of 520 individuals and tested them for association with reading and spelling measures...
  55. doi Familial dyslexia in a large Swedish family: a whole genome linkage scan
    Idor Svensson
    Department of Psychology, Linnæus University, 351 95 Växjö, Sweden
    Behav Genet 41:43-9. 2011
    ..In addition, six candidate genes (KIAA0319, DYX1C1, DCDC2, ROBO1, MRPL19 and C2ORF3) seem to be related to dyslexia...
  56. doi A theoretical molecular network for dyslexia: integrating available genetic findings
    G Poelmans
    Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Psychiatry 16:365-82. 2011
    ..We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I, DYX1C1 and DCDC2) fit into a theoretical molecular network involved in neuronal migration and neurite outgrowth...
  57. pmc Persistent spatial working memory deficits in rats following in utero RNAi of Dyx1c1
    C E Szalkowski
    Department of Psychology Behavioral Neuroscience, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA
    Genes Brain Behav 10:244-52. 2011
    ..Findings include evidence that variants in the human gene DYX1C1 may be associated with an increased risk of developmental dyslexia...
  58. pmc Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia
    Cecilia Marino
    Department of Child Psychiatry, Scientific Institute Eugenio Medea, Via Don Luigi Monza, 20, 23842 Bosisio Parini, LC, Italy
    Behav Genet 41:67-76. 2011
    ..We tested for association of variants of two DD susceptibility genes, DCDC2 and DYX1C1, in nuclear families ascertained through a proband with DD using concurrent measurements of language and ..
  59. pmc The effects of embryonic knockdown of the candidate dyslexia susceptibility gene homologue Dyx1c1 on the distribution of GABAergic neurons in the cerebral cortex
    T A Currier
    The Dyslexia Research Laboratory, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuroscience 172:535-46. 2011
    ..learning disability, and a number of candidate dyslexia susceptibility genes have been identified, including DYX1C1, KIAA0319, and DCDC2...
  60. pmc Investigation of dyslexia and SLI risk variants in reading- and language-impaired subjects
    D F Newbury
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Behav Genet 41:90-104. 2011
    ..In this study we investigate the role of variants in these genes (namely MRPL19/C20RF3, ROBO1, DCDC2, KIAA0319, DYX1C1, CNTNAP2, ATP2C2 and CMIP) in the aetiology of SLI and dyslexia...
  61. doi An examination of candidate gene SNPs for dyslexia in an Indian sample
    Shyamala K Venkatesh
    Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
    Behav Genet 41:105-9. 2011
    ..associations between DD and single nucleotide polymorphisms (SNPs) in a number of candidate genes, including DYX1C1, KIAA0319 and DCDC2...
  62. doi SNP variations in the 7q33 region containing DGKI are associated with dyslexia in the Finnish and German populations
    Hans Matsson
    Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen 7, S 141 83 Huddinge, Sweden
    Behav Genet 41:134-40. 2011
    Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children...
  63. pmc Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia
    S Jamadar
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 129:141-8. 2011
    ..morphometry (VBM) and 16 single nucleotide polymorphisms (SNPs) spanning FOXP2 and four RD-related genes, DCDC2, DYX1C1, KIAA0319 and TTRAP. Parallel-ICA identified five sMRI-SNP relationships...
  64. pmc Allelic variants of DYX1C1 are not associated with dyslexia in India
    Pushpa Saviour
    Human Genetics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore 570 006, India
    Indian J Hum Genet 14:99-102. 2008
    ..Recently, it has been suggested that allelic variants of gene, DYX1C1 influence dyslexia...
  65. ncbi Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event
    Yun Ji Kim
    Department of Biological Sciences, College of Natural Sciences, Pusan National University, Republic of Korea
    Genes Genet Syst 86:277-84. 2011
    b>DYX1C1 is a candidate gene for developmental dyslexia and has three alternative pre-mRNA spliced forms in the human genome. One of the transcripts contains an HERV-H LTR that could affect the expression level of DYX1C1...
  66. ncbi The genetics of reading disability
    Tracey L Petryshen
    Psychiatric and Neurodevelopment Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
    Curr Psychiatry Rep 11:149-55. 2009
    ..candidate genes have implicated DCDC2 and KIAA0319 in DYX2, as well as C2ORF3 and MRPL19 (DYX3), whereas DYX1C1/EKN1 (DYX1) and ROBO1 (DYX5) were found to be disrupted by rare translocation breakpoints in reading-disabled ..
  67. ncbi Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs
    P R Cox
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Genomics 63:97-107. 2000
    ..expression patterns make TMOD2 and TMOD3 candidate genes for amyotrophic lateral sclerosis 5 (ALS5) and dyslexia-1 (DYX1) and TMOD4 a candidate gene for limb girdle muscular dystrophy 1B (LGMD1B)...

Research Grants3

  1. Molecular Diagnosis of Dyslexia
    Seiyu Hosono; Fiscal Year: 2007
    ..At least two other RD genes have been identified as well: KIAA0319 and DYX1C1. RD alleles from all three genes are frequently present in RD subjects in the US and Canada, and the UK...
  2. Discovery of the 6p21.3 Reading Disability Gene
    Jeffrey R Gruen; Fiscal Year: 2010
    ..Four RD genes have emerged from chromosomal loci initially identified by genetic linkage: DYX1C1 (15q), ROBO1 (3q), KIAA0319 (6p22), and DCDC2 (6p22)...
  3. Genetic Interactions in Developmental Dyslexia
    Lauren McGrath; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..