DTNBP1

Summary

Gene Symbol: DTNBP1
Description: dystrobrevin binding protein 1
Alias: BLOC1S8, DBND, HPS7, My031, SDY, dysbindin, BLOC-1 subunit 8, Hermansky-Pudlak syndrome 7 protein, biogenesis of lysosomal organelles complex-1, subunit 8, biogenesis of lysosome-related organelles complex 1 subunit 8, dysbindin-1
Species: human

Top Publications

  1. ncbi Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 56:154-8. 2006
  2. ncbi Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction
    Elisabet Vilella
    Faculty of Medicine, Rovira i Virgili University, Reus, Spain
    J Psychiatr Res 42:278-88. 2008
  3. doi Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals
    V Markov
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Neuroimage 47:2016-22. 2009
  4. pmc Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location
    Konrad Talbot
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16886. 2011
  5. ncbi Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)
    M C Gornick
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    J Autism Dev Disord 35:831-8. 2005
  6. pmc Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner
    Satoko Oyama
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro ku, Tokyo, Japan
    PLoS ONE 4:e4199. 2009
  7. doi Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:478-83. 2011
  8. ncbi Association of the dysbindin gene with bipolar affective disorder
    Gerome Breen
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Am J Psychiatry 163:1636-8. 2006
  9. ncbi Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
  10. pmc Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
    Susmita R Datta
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 3:50. 2007

Research Grants

  1. Design and analysis of adaptive multistage genetic association studies
    Edwin van den Oord; Fiscal Year: 2010
  2. A genome-wide association study to detect genetic variation for schizophrenia
    Edwin van den Oord; Fiscal Year: 2010
  3. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
  4. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2006
  5. INHERITED DISEASES AFFECTING PLATELET FUNCTION
    RICHARD SWANK; Fiscal Year: 2004
  6. Dysbindin and the Mechanisms Controlling Homeostatic Synaptic Plasticity
    DION KAI DICKMAN; Fiscal Year: 2011
  7. DION KAI DICKMAN; Fiscal Year: 2014
  8. Darrick T Balu; Fiscal Year: 2014
  9. Graeme W Davis; Fiscal Year: 2016
  10. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012

Detail Information

Publications167 found, 100 shown here

  1. ncbi Association study of the dysbindin (DTNBP1) gene in schizophrenia from the Japanese population
    Mamoru Tochigi
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Neurosci Res 56:154-8. 2006
    b>Dysbindin (DTNBP1: dystrobrevin binding protein 1), located on 6p22.3, is a candidate susceptibility gene for schizophrenia...
  2. ncbi Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction
    Elisabet Vilella
    Faculty of Medicine, Rovira i Virgili University, Reus, Spain
    J Psychiatr Res 42:278-88. 2008
    ..In summary, these results may provide further support for an association between the dysbindin gene (DTNBP1) and schizophrenia, but not between the disease and DAO, DAOA, NRG1 and RGS4 or with the ..
  3. doi Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals
    V Markov
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Neuroimage 47:2016-22. 2009
    Genetic variation in dysbindin 1 (DTNBP1) gene region tagged by SNP rs1018381 exhibits a linkage with cognitive deficits in patients with schizophrenia and healthy subjects...
  4. pmc Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location
    Konrad Talbot
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e16886. 2011
    ..DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases...
  5. ncbi Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)
    M C Gornick
    Child Psychiatry Branch, IRP, National Institute of Mental Health, NIH, Bethesda, MD 20892 1600, USA
    J Autism Dev Disord 35:831-8. 2005
    Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13...
  6. pmc Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner
    Satoko Oyama
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro ku, Tokyo, Japan
    PLoS ONE 4:e4199. 2009
    DTNBP1 has been recognized as a schizophrenia susceptible gene, and its protein product, dysbindin-1, is down-regulated in the brains of schizophrenic patients...
  7. doi Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:478-83. 2011
    The dysbindin-1 and neuregulin-1 (NRG-1) genes are related to schizophrenia...
  8. ncbi Association of the dysbindin gene with bipolar affective disorder
    Gerome Breen
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Am J Psychiatry 163:1636-8. 2006
    ..The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and ..
  9. ncbi Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies...
  10. pmc Failure to confirm allelic and haplotypic association between markers at the chromosome 6p22.3 dystrobrevin-binding protein 1 (DTNBP1) locus and schizophrenia
    Susmita R Datta
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, University College London Medical School, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London, W1T 4JF, UK
    Behav Brain Funct 3:50. 2007
    Previous linkage and association studies may have implicated the Dystrobrevin-binding protein 1 (DTNBP1) gene locus or a gene in linkage disequilibrium with DTNBP1 on chromosome 6p22.3 in genetic susceptibility to schizophrenia.
  11. doi Differential RNA expression between schizophrenic patients and controls of the dystrobrevin binding protein 1 and neuregulin 1 genes in immortalized lymphocytes
    Y C Chagnon
    Laval University Research Center Robert Giffard, Quebec, Quebec, Canada
    Schizophr Res 100:281-90. 2008
    The dystrobrevin binding protein 1 (DTNBP1) and neuregulin 1 (NRG1) genes have been related to schizophrenia (SZ) and bipolar disorder (BP) by several whole-genome linkage and associations studies...
  12. doi DTNBP1 haplotype influences baseline assessment scores of schizophrenic in-patients
    Chi Un Pae
    Department of Psychiatry, Kangnam St Mary s Hospital, The Catholic University of Korea College of Medicine, South Korea
    Neurosci Lett 440:150-4. 2008
    b>Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required...
  13. pmc Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Schizophr Res 106:208-17. 2008
    ..003). The 3-locus model involved the IL3 (rs2069803), RGS4 (rs2661319), and DTNBP1 (rs2619539) genes...
  14. doi Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Psychiatry Clin Neurosci 63:550-6. 2009
    The dysbindin gene (dystrobrevin binding protein 1: DTNBP1) is a susceptibility gene for schizophrenia...
  15. pmc The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample
    Brien Riley
    Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA
    Schizophr Res 115:245-53. 2009
    b>DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples.
  16. doi Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia
    Brion S Maher
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Hum Hered 69:71-9. 2010
    ..We contend that current approaches may obscure interesting phenomena in genetic association data. However, an appropriate approach to examining heterogeneity across studies is lacking...
  17. ncbi No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
    Schizophr Res 60:167-72. 2003
    ..association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia...
  18. pmc The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease
    Ann Van Den Bogaert
    Department of Medical Genetics, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 73:1438-43. 2003
    We have investigated the gene for dystrobrevin-binding protein 1 (DTNBP1), or dysbindin, which has been strongly suggested as a positional candidate gene for schizophrenia, in three samples of subjects with schizophrenia and unaffected ..
  19. pmc Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein
    Ramin Nazarian
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochem J 395:587-98. 2006
    b>Dysbindin was identified as a dystrobrevin-binding protein potentially involved in the pathogenesis of muscular dystrophy...
  20. ncbi Dysbindin genotype and negative symptoms in schizophrenia
    Pamela DeRosse
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:532-4. 2006
    Converging evidence has demonstrated an association between variants in the dysbindin gene (DTNBP1) and schizophrenia...
  21. ncbi Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients
    Sarah Tosato
    Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy
    Am J Med Genet B Neuropsychiatr Genet 144:647-59. 2007
    There is evidence suggesting that Dysbindin (DTNBP1) is a susceptibility gene for schizophrenia in Caucasian, Chinese, and Japanese populations...
  22. ncbi Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain
    M A Benson
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    J Biol Chem 276:24232-41. 2001
    ..Here we describe the identification of a dysbindin, a novel dystrobrevin-binding protein...
  23. pmc Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia
    Richard E Straub
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Am J Hum Genet 71:337-48. 2002
    ..this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia...
  24. pmc Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families
    Sibylle G Schwab
    Molecular Genetics Laboratory, University of Bonn, Bonn, Germany
    Am J Hum Genet 72:185-90. 2003
    Genetic variants in a gene on 6p22.3, dysbindin, have been shown recently to be associated with schizophrenia (Straub et al. 2002a)...
  25. ncbi Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)
    Steven L Ciciotte
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 101:4402-7. 2003
    ....
  26. ncbi Identification of a high-risk haplotype for the dystrobrevin binding protein 1 (DTNBP1) gene in the Irish study of high-density schizophrenia families
    E J C G van den Oord
    Department of Psychiatry and Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
    Mol Psychiatry 8:499-510. 2003
    ..1). The cluster was identified as the human dystrobrevin binding protein 1 gene (DTNBP1) by sequence database comparisons and homology with mouse DTNBP1. (2)...
  27. ncbi Family-based association study of DTNBP1 in 6p22.3 and schizophrenia
    J X Tang
    Mol Psychiatry 8:717-8. 2003
  28. pmc Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 35:84-9. 2003
    ..7). Here we show that the sdy mutant mouse expresses no dysbindin protein owing to a deletion in the gene Dtnbp1 (encoding dysbindin) and that mutation of the human ortholog ..
  29. ncbi Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1)
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, Wales
    Arch Gen Psychiatry 61:336-44. 2004
    Recent research suggests that variation in the gene encoding dystrobrevin binding protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype has been identified in more than 1 study.
  30. ncbi Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)
    Marta Starcevic
    Department of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Biol Chem 279:28393-401. 2004
    ..The complex is known to contain the coiled-coil-forming proteins, Pallidin, Muted, Cappuccino, and Dysbindin. The genes encoding these proteins are defective in inbred mouse strains that serve as models of Hermansky-..
  31. ncbi Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria
    George Kirov
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    Biol Psychiatry 55:971-5. 2004
    The gene encoding the dystrobrevin binding protein (DTNBP1) has been implicated in the pathogenesis of schizophrenia by several association studies...
  32. pmc Dysbindin-1 and schizophrenia: from genetics to neuropathology
    Michael J Owen
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
    J Clin Invest 113:1255-7. 2004
    The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al...
  33. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..between schizophrenia and certain haplotypes of single-nucleotide polymorphisms in the gene encoding dysbindin-1 at 6p22.3...
  34. ncbi Linkage disequlibrium in the DTNBP1 (dysbindin) gene region and on chromosome 1p36 among psychotic patients from a genetic isolate in Israel: findings from identity by descent haplotype sharing analysis
    Yoav Kohn
    Biological Psychiatry Laboratory, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem, Israel 91120
    Am J Med Genet B Neuropsychiatr Genet 128:65-70. 2004
    ..One was for psychotic patients with any diagnosis at the location of dysbindin, a gene previously associated with schizophrenia...
  35. ncbi The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations
    D Hall
    The Rockefeller University, Human Neurogenetics Laboratory, New York, NY 10021, USA
    Genes Brain Behav 3:240-8. 2004
    ..strong candidate schizophrenia susceptibility genes; G72, neuregulin 1 (NRG1) and dystrobrevin-binding protein 1 (DTNBP1) in two independent datasets of patients with distinct genetic backgrounds...
  36. ncbi The dysbindin gene in major depression: an association study
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 129:55-8. 2004
    ..In this context, the dysbindin gene (dystrobrevin-binding-protein 1, DTNBP1), which was recently reported to be associated with schizophrenia ..
  37. ncbi Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
    Genetic variation in dysbindin (DTNBP1: dystrobrevin-binding protein 1) has recently been shown to be associated with schizophrenia. The dysbindin gene is located at chromosome 6p22...
  38. pmc Association of the DTNBP1 locus with schizophrenia in a U.S. population
    Birgit Funke
    Harvard Medical School Partners Center for Genetics and Genomics, Boston, MA 02115, USA
    Am J Hum Genet 75:891-8. 2004
    Linkage and association studies have recently implicated dystrobrevin-binding protein 1 (DTNBP1) in the etiology of schizophrenia...
  39. ncbi Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
    Rachel Raybould
    Department of Psychological Medicine, Wales College of Medicine, Cardiff University, Cardiff, Wales, UK
    Biol Psychiatry 57:696-701. 2005
    Several studies support the dysbindin (dystrobrevin binding protein 1) gene (DTNBP1) as a susceptibility gene for schizophrenia...
  40. ncbi Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression
    Nicholas J Bray
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, UK
    Hum Mol Genet 14:1947-54. 2005
    The DTNBP1 gene, encoding dysbindin, is now generally considered to be a susceptibility gene for schizophrenia...
  41. ncbi Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations
    T Li
    Department of Psychiatry, Psychiatry Laboratory, West China Hospital, Sichuan University, PR China
    Mol Psychiatry 10:1037-44. 2005
    The dystrobrevin-binding protein 1 (DTNBP1) gene on chromosome 6p has emerged as a potential susceptibility gene for schizophrenia...
  42. ncbi DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals
    Andreas J Fallgatter
    Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry, University of Wurzburg, Wurzburg, Bavaria, Germany
    Neuropsychopharmacology 31:2002-10. 2006
    DTNBP1 (dysbindin) is one of the several putative schizophrenia genes supported by association, neuroanatomical, and cellular studies...
  43. ncbi Genetic variation in DTNBP1 influences general cognitive ability
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Albert Einstein College of Medicine, Glen Oaks, NY 11004, USA
    Hum Mol Genet 15:1563-8. 2006
    ..The gene for dysbindin-1 (DTNBP1) is located at 6p and has also been implicated in schizophrenia, a neuropsychiatric disorder ..
  44. pmc BLOC-1 interacts with BLOC-2 and the AP-3 complex to facilitate protein trafficking on endosomes
    Santiago M Di Pietro
    Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
    Mol Biol Cell 17:4027-38. 2006
    ..These findings support the idea that BLOC-1 and -2 represent hitherto unknown components of the endosomal protein trafficking machinery...
  45. ncbi Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study
    Gary Donohoe
    Department of Psychology and Trinity Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    Neuropsychologia 45:454-8. 2007
    ..We investigated the association between genotype and cognitive performance for a Dysbindin risk haplotype which is associated with schizophrenia in our sample...
  46. ncbi The dysbindin gene (DTNBP1) and schizophrenia: no support for an association in the Korean population
    Eun Jeong Joo
    Department of Neuropsychiatry, Eulji University School of Medicine, Eulji General Hospital, 280 1 Hagye 1 dong, Nowon Gu, Seoul 139 711, South Korea
    Neurosci Lett 407:101-6. 2006
    The dysbindin gene (DTNBP1) is located in chromosome 6p22.3, one of the regions of positive linkage for schizophrenia. A strong genetic association between DTNBP1 and schizophrenia has been replicated through many recent studies...
  47. pmc Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia
    Mousumi Mutsuddi
    Psychiatric Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA
    Am J Hum Genet 79:903-9. 2006
    b>DTNBP1 was first identified as a putative schizophrenia-susceptibility gene in Irish pedigrees, with a report of association to common genetic variation...
  48. pmc DTNBP1 genotype influences cognitive decline in schizophrenia
    Katherine E Burdick
    Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, United States
    Schizophr Res 89:169-72. 2007
    ..The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).
  49. ncbi Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, South Korea
    Am J Med Genet B Neuropsychiatr Genet 144:701-3. 2007
    We investigated a possible association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID)...
  50. ncbi The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland
    Joni A Turunen
    Department of Molecular Medicine, National Public Health Institute, Biomedicum, P O Box 104, FI 00251, Helsinki, Finland
    Schizophr Res 91:27-36. 2007
    ..Significant associations between schizophrenia and neuregulin 1 (NRG1) and dysbindin (DTNBP1) were first reported in 2002 and studies in several populations have since independently reported ..
  51. ncbi No association evidence between schizophrenia and dystrobrevin-binding protein 1 (DTNBP1) in Taiwanese families
    Chih Min Liu
    Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
    Schizophr Res 93:391-8. 2007
    ..to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1)...
  52. ncbi Dysbindin gene variants are associated with bipolar I disorder in a Korean population
    E J Joo
    Department of Neuropsychiatry, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea
    Neurosci Lett 418:272-5. 2007
    The dysbindin gene (DTNBP1) has been associated with schizophrenia in several populations...
  53. pmc Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings
    Janneke R Zinkstok
    Department of Psychiatry, Academic Medical Center of the University of Amsterdam, The Netherlands
    Behav Brain Funct 3:19. 2007
    The dystrobrevin-binding protein 1 (DTNBP1) gene is a susceptibility gene for schizophrenia. There is growing evidence that DTNPB1 contributes to intelligence and cognition...
  54. pmc DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene
    Jubao Duan
    Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare and Feinberg School of Medicine, Northwestern University, Evanston, Ill, USA
    Hum Hered 64:97-106. 2007
    b>Dysbindin (DTNBP1) has been identified as a susceptibility gene for schizophrenia (SZ) through a positional approach...
  55. ncbi Association study between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia: a meta-analysis
    Dawei Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 96:112-8. 2007
    Positional, functional and association studies have strongly implicated the dystrobrevin binding protein 1 gene (DTNBP1) as a promising novel candidate gene for schizophrenia...
  56. ncbi Early visual processing deficits in dysbindin-associated schizophrenia
    Gary Donohoe
    Neuropsychiatric Genetics Group, Institute of Molecular Medicine, Trinity College Dublin, St James Hospital, Dublin, Ireland
    Biol Psychiatry 63:484-9. 2008
    Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing...
  57. pmc Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
    Cynthia Shannon Weickert
    MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Schizophr Res 98:105-10. 2008
    Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia...
  58. ncbi Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization
    Yukihiko Iizuka
    Genes, Cognition, and Psychosis Program, Clinical Brain Disorders Branch, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892 1385, USA
    J Neurosci 27:12390-5. 2007
    The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)...
  59. doi No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    The authors carried out a genetic association study of 14 schizophrenia candidate genes (RGS4, DISC1, DTNBP1, STX7, TAAR6, PPP3CC, NRG1, DRD2, HTR2A, DAOA, AKT1, CHRNA7, COMT, and ARVCF)...
  60. doi Common risk genes for affective and schizophrenic psychoses
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strabe 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:37-40. 2008
    ..The reasons are a series of cross-diagnostic molecular-genetic discoveries: specific alleles in the genes for dysbindin (DTNBP1), neuregulin (NRG1) and DAOA (G72/G30) reveal associations for each of both groups of disorders in the ..
  61. doi Variation in the dysbindin gene and normal cognitive function in three independent population samples
    M Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:218-27. 2009
    ..Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and ..
  62. doi Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS)
    Darya Gaysina
    MRC SGDP Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:836-44. 2009
    ..There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD)..
  63. doi Dysbindin gene (DTNBP1) and schizophrenia in Korean population
    Chi Un Pae
    Department of Psychiatry, The Catholic University of Korea College of Medicine, 505 Banpo Dong, Seocho Gu, Seoul 137 701, South Korea
    Eur Arch Psychiatry Clin Neurosci 259:137-42. 2009
    b>Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today...
  64. doi Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects
    T Kircher
    Department of Psychiatry and Psychotherapy, Philipps University Marburg, Germany
    Psychol Med 39:1657-65. 2009
    ..The dystrobrevin-binding protein 1 (DTNBP1) gene located at chromosome 6p22.3 is one of the most often replicated vulnerability genes for schizophrenia...
  65. pmc TRIM32 is an E3 ubiquitin ligase for dysbindin
    Matthew Locke
    Department of Psychological Medicine, Cardiff University, Cardiff, UK
    Hum Mol Genet 18:2344-58. 2009
    ..Using the yeast two-hybrid system, we found that TRIM32 binds and ubiquitinates dysbindin, a protein implicated in the genetic aetiology of schizophrenia, augmenting its degradation...
  66. doi A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    World J Biol Psychiatry 11:431-8. 2010
    ..A genetic variation in the dysbindin gene (DTNBP1: dystrobrevin binding protein 1), a susceptibility gene for schizophrenia, has been reported to be ..
  67. pmc Dysbindin-1 in dorsolateral prefrontal cortex of schizophrenia cases is reduced in an isoform-specific manner unrelated to dysbindin-1 mRNA expression
    Junxia Tang
    Center for Neurobiology and Behavior in the Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104 3403, USA
    Hum Mol Genet 18:3851-63. 2009
    ..Reduced expression of this gene and of its encoded protein, dysbindin-1, have been reported in the brains of schizophrenia cases...
  68. doi The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, 52074 Aachen, Germany
    Hum Brain Mapp 31:203-9. 2010
    ..the effect of the single nucleotide polymorphism (SNP) rs1018381 (P1578) of the dystrobrevin-binding protein 1 (DTNBP1) on brain activity in 84 healthy subjects assessed by functional magnetic resonance imaging (fMRI) while they ..
  69. doi Dysbindin modulates brain function during visual processing in children
    A Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, UK
    Neuroimage 49:817-22. 2010
    ..Several genetic studies have identified dystrobrevin binding protein 1 (DTNBP1, also known as dysbindin) as a potential susceptibility gene for schizophrenia, but its impact on brain function is poorly understood...
  70. doi Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals
    Valentin Markov
    Department of Psychiatry and Psychotherapy, Medical Faculty, RWTH Aachen University, Aachen, Germany
    Hum Brain Mapp 31:266-75. 2010
    ..A strong linkage between genetic variants in the dysbindin 1 gene and schizophrenia has been demonstrated...
  71. doi Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia
    Katrine V Wirgenes
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Neuropsychobiology 60:31-6. 2009
    ..Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both involved in glutamate receptor function, reported associations with ..
  72. doi Mixture model clustering of phenotype features reveals evidence for association of DTNBP1 to a specific subtype of schizophrenia
    Jaana Wessman
    Department of Molecular Medicine, Helsinki, Finland
    Biol Psychiatry 66:990-6. 2009
    While DTNBP1, DISC1, and NRG1 have been extensively studied as candidate genes of schizophrenia, results remain inconclusive...
  73. pmc Association study of DTNBP1 with schizophrenia in a US sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Psychiatr Genet 19:292-304. 2009
    ..this original finding, but the reported findings are highly diverse and at least five pathways by which dysbindin protein might be involved in schizophrenia have been proposed...
  74. pmc Dysbindin-1 genotype effects on emotional working memory
    C Wolf
    Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Bangor University, Bangor, UK
    Mol Psychiatry 16:145-55. 2011
    We combined functional imaging and genetics to investigate the behavioral and neural effects of a dysbindin-1 (DTNBP1) genotype associated with the expression level of this important synaptic protein, which has been implicated in ..
  75. pmc A reappraisal of the association between Dysbindin (DTNBP1) and schizophrenia in a large combined case-control and family-based sample of German ancestry
    Jana Strohmaier
    Division of Genetic Epidemiology, Central Institute of Mental Health, Mannheim, Germany
    Schizophr Res 118:98-105. 2010
    b>Dysbindin (DTNBP1) is a widely studied candidate gene for schizophrenia (SCZ); however, inconsistent results across studies triggered skepticism towards the validity of the findings...
  76. pmc Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes
    Aaron Marley
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e9325. 2010
    b>Dysbindin, a cytoplasmic protein long known to function in the biogenesis of specialized lysosome-related organelles (LROs), has been reported to reduce surface expression of D2 dopamine receptors in neurons...
  77. doi Analysis of HapMap tag-SNPs in dysbindin (DTNBP1) reveals evidence of consistent association with schizophrenia
    J Voisey
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Eur Psychiatry 25:314-9. 2010
    Dystrobrevin binding protein 1 (DTNBP1), or dysbindin, is thought to be critical in regulating the glutamatergic system...
  78. pmc The effects of a DTNBP1 gene variant on attention networks: an fMRI study
    Markus Thimm
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Behav Brain Funct 6:54. 2010
    ..Given the high heritability of schizophrenia the question arises if impaired function of these networks is modulated by susceptibility genes and detectable in healthy risk allele carriers...
  79. doi Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis
    Mar Fatjó-Vilas
    Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona, Centro de Investigación Biomédica en Red de Salud Mental, Spain
    Am J Med Genet B Neuropsychiatr Genet 156:322-33. 2011
    b>Dysbindin-1 is a relatively ubiquitous protein in the brain which is involved in the modulation of synaptic homeostasis. The dysbindin-1 gene (DTNBP1) has been associated with schizophrenia and bipolar disorder diagnoses...
  80. pmc Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene
    Ariana P Mullin
    Graduate Program in Neuroscience, Emory University, Atlanta, GA, USA
    Mol Neurobiol 44:53-64. 2011
    There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia...
  81. doi The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study
    Thomas Nickl-Jockschat
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 60:847-53. 2012
    ..We here present a study on the effects of a Dysbindin schizophrenia susceptibility gene variant on fiber tract integrity in healthy young subjects...
  82. ncbi Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin
    Konrad Talbot
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Mol Genet 15:3041-54. 2006
    Variations in the gene encoding the novel protein dysbindin-1 (DTNBP1) are among the most commonly reported genetic variations associated with schizophrenia...
  83. ncbi Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece
    Biol Psychiatry 62:784-92. 2007
    ..It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia...
  84. ncbi The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 63:191-6. 2008
    The dysbindin (DTNBP1 [dystrobrevin-binding protein 1]) gene has repeatedly been shown to be associated with schizophrenia across diverse populations...
  85. pmc Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii
    C J Carter
    176 Downs Road, Hastings, East Sussex, TN34 2DZ, UK
    Schizophr Bull 35:1163-82. 2009
    ..schizophrenia 1 (DISC1) controls the microtubule network that is used by viruses as a route to the nucleus, while DTNBP1, MUTED, and BLOC1S3 regulate endosomal to lysosomal routing that is also important in viral traffic...
  86. ncbi Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
    N Muller
    Hospital for Psychiatry and Psychotherapy, Ludwig Maximilians Universitat, 80336 Munchen, Germany
    Neurotox Res 10:131-48. 2006
    ..This view is supported by genetic findings of the neuregulin- and dysbindin genes, which have functional impact on the glutamatergic system...
  87. pmc Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios
    M Daniele Fallin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA
    Am J Hum Genet 77:918-36. 2005
    ..In addition, six genes (DPYSL2, DTNBP1, G30/G72, GRID1, GRM4, and NOS1) showed overlapping suggestive evidence of association in both disorders...
  88. ncbi [Advances in neurobiological understanding of schizophrenia. Perspectives for new therapeutic concepts]
    P Falkai
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Göttingen, Gottingen
    Nervenarzt 77:S65-74; quiz S75-6. 2006
    ..However, recently three postulated disposition genes for schizophrenia have been increasingly better confirmed: dysbindin, neuregulin-1, and G(72)/DAOA genes...
  89. ncbi The genetics of schizophrenia: glutamate not dopamine?
    David A Collier
    Section of Molecular Genetics, P82, Division of Psychological Medicine, The Institute of Psychiatry, De Crespigny Park, Denmark Hill, SE5 8AF, London, UK
    Eur J Pharmacol 480:177-84. 2003
    ..the identification of several plausible susceptibility genes, including neuregulin 1, proline dehydrogenase and dysbindin. Interestingly, these genes point more towards a role for the glutamate pathway rather than the dopamine pathway ..
  90. ncbi Genetic mechanisms of psychosis: in vivo and postmortem genomics
    Daniel R Weinberger
    National Institutes of Health, Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, Bethesda, Maryland 20892, USA
    Clin Ther 27:S8-15. 2005
    ..Characterizing genes--and translating their effects on brain development and function--has potential implications for improving the prevention and treatment of schizophrenia...
  91. ncbi Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1
    Paul J Harrison
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Novartis Found Symp 288:246-55; discussion 255-9, 276-81. 2007
    ..The evidence is strong for neuregulin 1, dysbindin and DISC1, and moderate for several others. However, there are key unanswered questions...
  92. ncbi [Genetic risk factors in schizophrenia]
    H Fabisch
    Universitätsklinik für Psychiatrie, Medizinische Universitat Graz, Osterreich
    Fortschr Neurol Psychiatr 73:S44-50. 2005
    ..The findings for alleles of dysbindin, neuregulin 1, DAO, COMT, PRODH, ZDHHC and DISC are less clear...
  93. ncbi Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses
    Naoya Sawamura
    Consolidated Research Institute for Advanced Science and Medical Care ASMeW, Waseda University, 513 Wasedatsurumaki cho, Shinjuku ku, Tokyo 162 0041, Japan
    Ann N Y Acad Sci 1086:126-33. 2006
    ..Different from several other susceptibility genes for schizophrenia, such as neuregulin-1 and dysbindin, there are two independent pedigrees in which genetic variations of DISC1 directly segregate with major mental ..
  94. doi Performance of five phalangeal QUS parameters in the evaluation of gonadal-status, age and vertebral fracture risk compared with DXA
    Carlina V Albanese
    Service of Bone Densitometry and Ultrasound, Department of Radiological Sciences, University of Rome Sapienza School of Medicine, Viale R Elena 324, Rome, Italy
    Ultrasound Med Biol 35:537-44. 2009
    ..Ultrasound Bone Profile Index (UBPI), fast-wave amplitude (FWA), bone transmission time (BTT) and signal dynamic (SDY)-measured at the phalanges of the hand in discriminating women with vertebral fracture and their relationship with ..
  95. pmc Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency
    Verónica T Cheli
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:861-78. 2010
    ..Loss-of-function mutations in two of these genes, DTNBP1 and BLOC1S3, cause Hermansky-Pudlak syndrome, a human disorder characterized by defective biogenesis of lysosome-..
  96. ncbi Abnormal dysbindin expression in cerebellar mossy fiber synapses in the mdx mouse model of Duchenne muscular dystrophy
    Roy V Sillitoe
    Department of Cell Biology and Anatomy, and Genes and Development Research Group, Faculty of Medicine, The University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 23:6576-85. 2003
    ..b>Dysbindin is a novel component of the DPC, which binds to beta-dystrobrevin and may serve as an adaptor protein that links ..
  97. ncbi Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex
    Babette Gwynn
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Blood 104:3181-9. 2004
    ..Seven genes cause HPS in humans (HPS1-HPS7) and at least 15 nonallelic mutations cause HPS in mice...
  98. ncbi Distance impairs postural stability only under binocular viewing
    Thanh Thuan Le
    IRIS Group, UMR 7152 Laboratoire de Physiologie de la Perception et de l Action LPPA, CNRS College de France, 11, Place M Berthelot, Paris, France
    Vision Res 46:3586-93. 2006
    ..For both groups of subjects, proximity decreased the area of CoP, the standard deviation of antero-posterior sway (SDy) and the variance of speed...
  99. ncbi Dystrobrevins in muscle and non-muscle tissues
    Melissa L J Rees
    Department of Molecular Medicine, Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK
    Neuromuscul Disord 17:123-34. 2007
    ..Dystrobrevin binding partner DTNBP1 (dysbindin) is a probable susceptibility gene for schizophrenia and bipolar affective disorder in some populations...
  100. ncbi Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    The schizophrenia-susceptibility gene dysbindin (DTNBP1 on 6p22.3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex...
  101. ncbi Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin
    Asimina Kouloumenta
    Cell Biology Division, Center of Basic Research, Biomedical Research Foundation Academy of Athens, Athens 11527, Greece
    J Biol Chem 282:35211-21. 2007
    ..binds to a 413-kDa TRIM-like protein, myospryn, originally identified as the muscle-specific partner of dysbindin, a component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)...

Research Grants22

  1. Design and analysis of adaptive multistage genetic association studies
    Edwin van den Oord; Fiscal Year: 2010
    ..The goal of this project is to develop a flexible framework for designing these studies in a cost-effective way and optimize subsequent replication efforts. ..
  2. A genome-wide association study to detect genetic variation for schizophrenia
    Edwin van den Oord; Fiscal Year: 2010
    ..We attempt to contribute to the rigorous evaluation of the common disease/common genetic variant model for schizophrenia, which is key to further understand its pathophysiology and develop effective treatments. ..
  3. MULTICENTER GENETIC STUDIES OF SCHIZOPHRENIA
    Brien Riley; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. Structure and Function of Antiparallel Coiled Coils
    MARTHA OAKLEY; Fiscal Year: 2006
    ..maintenance of muscle integrity that appear to contain helical hairpin domains: dystrophin, dystrobrevin, and dysbindin. Finally, one of the most surprising recent findings in this area is that structural maintenance of chromosome (..
  5. INHERITED DISEASES AFFECTING PLATELET FUNCTION
    RICHARD SWANK; Fiscal Year: 2004
    ..Aims of the proposal are to: 1) complete the identification and partial characterization of the mouse sandy (sdy) HPS gene; 2) identify and partially characterize the mouse light ear (le) HPS gene; 3) identify and partially ..
  6. Dysbindin and the Mechanisms Controlling Homeostatic Synaptic Plasticity
    DION KAI DICKMAN; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Dysbindin and the Mechanisms Controlling the Homeostatic Modulation of Presynaptic Neurotransmitter Release Nervous system function remains remarkably stable despite the many changes that occur ..
  7. DION KAI DICKMAN; Fiscal Year: 2014
    Project Summary Dysbindin and the Mechanisms Controlling the Homeostatic Modulation of Presynaptic Neurotransmitter Release Nervous system function remains remarkably stable despite the many changes that occur during the development, ..
  8. Darrick T Balu; Fiscal Year: 2014
    ..utilize two mutant mouse models with impaired glutamatergic transmission, serine racemase deficient (SR-/-) and dysbindin deficient (dys-/-) mice, to identify disturbances in common final pathways regulated by NMDAR activity that ..
  9. Graeme W Davis; Fiscal Year: 2016
    ..Among our recent successes has been the demonstration that a schizophrenia associated gene in human, dysbindin, is critical for homeostatic signaling...
  10. Disease-related defects in dendritic cell processing of bacterial antigens
    Michael S Marks; Fiscal Year: 2012
    ..b>HPS7 and HPS8 patients lack a different complex, BLOC-1, that mediates different transport steps in other LRO- producing ..
  11. IGF::OT::IGF
    Vivian Leung; Fiscal Year: 2013
    ..The most common diagnoses that increase risk for sudden death in the young (SDY) include Dravet Syndrome, other genetic forms of epilepsy, hypertrophic cardiomyopathy, coronary artery anomalies ..
  12. Imaging the Impact of Glutamate Liability Genes in Schizophrenia
    Angus Macdonald; Fiscal Year: 2009
    ..1) The first stage will test whether five glutamate moderating genes (RGS4, DTNBP1, GRM3, NRG1, and DAOA) are associated with individual differences in context processing in a large general ..
  13. Neurobiology of Dysbindin in Schizophrenia and sdy Mouse
    STEVEN ARNOLD; Fiscal Year: 2008
    ..by applicant): Twelve studies to date report significant associations between certain haplotypes in the dysbindin gene and schizophrenia (SZ)...
  14. Understanding the neuronal function of dysbindin
    IAN OROZCO; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Recent studies have linked the dysbindin gene to the complex neurological disorder of schizophrenia...
  15. PREQUEL Study In PRE-manifest HD of CoQ10/UbiquinonE Leading to Preventive Trials
    Christopher A Ross; Fiscal Year: 2010
    ....
  16. In silico genome scan with high-throughput addiction related phenotypes in mice
    Edwin van den Oord; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Neurodegeneration and Polyglutamine Toxicity DRPLA
    Christopher Ross; Fiscal Year: 2007
    ..Proteolytic cleavage would be an especially good target for therapeutic interventions. [unreadable] [unreadable]..
  18. Transgenic Models of Huntington's Disease
    Christopher Ross; Fiscal Year: 2006
    ..The new mouse model will be useful for studying pathogenic features of HD, and for testing experimental therapeutic interventions. ..
  19. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..
  20. Statistical Genetic Analysis of Orofacial Cleft Families
    Brion Maher; Fiscal Year: 2008
    ..Overall, the proposed analytical approaches applied in this large dataset will shed significant light on the contribution of specific genes, and their interactions, to CUP. [unreadable] [unreadable] [unreadable]..