DRD2

Summary

Gene Symbol: DRD2
Description: dopamine receptor D2
Alias: D2DR, D2R, D(2) dopamine receptor, dopamine D2 receptor, dopamine receptor D2 isoform, seven transmembrane helix receptor
Species: human

Top Publications

  1. ncbi Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 18:593-5. 2003
  2. ncbi The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood
    Paul Cinciripini
    Department of Behavioral Science, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nicotine Tob Res 6:229-39. 2004
  3. doi Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    Elitza T Betcheva
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 54:98-107. 2009
  4. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
  5. pmc Dopamine DRD2 polymorphism alters reversal learning and associated neural activity
    Gerhard Jocham
    Cognitive Neurology Research Group, Max Planck Institute for Neurological Research, D 50931 Cologne, Germany
    J Neurosci 29:3695-704. 2009
  6. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
  7. pmc Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors
    Kenneth Blum
    Department of Psychiatry, School of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL 32601, USA
    Int J Environ Res Public Health 8:4425-59. 2011
  8. ncbi Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:2844-53. 2007
  9. doi Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Neurosci 28:12032-8. 2008
  10. doi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009

Research Grants

  1. Anissa Abi-Dargham; Fiscal Year: 2014
  2. Marc G Caron; Fiscal Year: 2016
  3. IAN THOMAS ELLWOOD; Fiscal Year: 2015
  4. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
  5. Christoph Kellendonk; Fiscal Year: 2016
  6. Relating GPCRs by biased ligands for enhanced therapeutic efficacy
    MICHAEL JAMES KEISER; Fiscal Year: 2013
  7. Fu Ming Zhou; Fiscal Year: 2014
  8. David M Lyons; Fiscal Year: 2014
  9. Laurie J Ozelius; Fiscal Year: 2016
  10. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013

Detail Information

Publications292 found, 100 shown here

  1. ncbi Dopamine D2 receptor TaqIA and TaqIB polymorphisms in Parkinson's disease
    Eng King Tan
    Department of Neurology, Singapore General Hospital, Singapore
    Mov Disord 18:593-5. 2003
    In a case control study, we examined the association of DRD2 Taq1A and Taq1B polymorphisms and risk of PD, and evaluated the strength of linkage disequilibrium of the polymorphisms...
  2. ncbi The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood
    Paul Cinciripini
    Department of Behavioral Science, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Nicotine Tob Res 6:229-39. 2004
    This study evaluated the relationship between smoking cessation treatment outcome and the DRD2 polymorphism...
  3. doi Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population
    Elitza T Betcheva
    Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 54:98-107. 2009
    ..Of the 183 SNPs successfully genotyped, only 1 SNP, rs6277 (C957T) in the DRD2 gene (P=0.0010, odds ratio=1...
  4. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    ..presence of the A1 allele of the TaqIA restriction fragment length polymorphism, which is associated with dopamine D2 receptor (DRD2) gene binding in the striatum and compromised striatal dopamine signaling...
  5. pmc Dopamine DRD2 polymorphism alters reversal learning and associated neural activity
    Gerhard Jocham
    Cognitive Neurology Research Group, Max Planck Institute for Neurological Research, D 50931 Cologne, Germany
    J Neurosci 29:3695-704. 2009
    In humans, presence of an A1 allele of the DRD2/ANKK1-TaqIa polymorphism is associated with reduced expression of dopamine (DA) D(2) receptors in the striatum...
  6. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    We investigated the association of the dopamine D2 receptor (DRD2) Taq1A polymorphism and alcoholism, using meta-analytic techniques, and specifically undertook an investigation of possible publication bias...
  7. pmc Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors
    Kenneth Blum
    Department of Psychiatry, School of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL 32601, USA
    Int J Environ Res Public Health 8:4425-59. 2011
    ..We evaluated the potential association of four variants of dopaminergic candidate genes in RDS (dopamine D1 receptor gene [DRD1]; dopamine D2 receptor gene [DRD2]; dopamine transporter gene [DAT1]; dopamine beta-hydroxylase gene [DBH]).
  8. ncbi Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples
    Bao zhu Yang
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Hum Mol Genet 16:2844-53. 2007
    There have been many conflicting reports concerning the association of the DRD2 locus with alcohol dependence (AD)...
  9. doi Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Neurosci 28:12032-8. 2008
    ..Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory...
  10. doi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD...
  11. pmc Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:20552-7. 2007
    Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous...
  12. ncbi Interacting effects of genetic predisposition and depression on adolescent smoking progression
    Janet Audrain-McGovern
    Department of Psychiatry, Abramson Cancer Center, University of Pennsylvania, Suite 4100, 3535 Market Street, Philadelphia, PA 19104, USA
    Am J Psychiatry 161:1224-30. 2004
    ..The goal of the present study was to identify specific genetic associations with smoking progression in adolescents and to determine whether these genetic effects on smoking practices are potentiated by depression symptoms...
  13. doi Potential association of DRD2 and DAT1 genetic variation with heroin dependence
    Qiao Fang Hou
    Key Laboratory of the National Ministry of Health for Forensic Sciences, College of Medicine, Xi an Jiaotong University, 76 Yanta West Road, Xi an 710061, PR China
    Neurosci Lett 464:127-30. 2009
    The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3'untranslated region VNTR genetic variations with heroin addiction...
  14. ncbi Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians
    C P Jenkinson
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Digestive Diabetes and Kidney Diseases, National Institutes of Health, Arizona, USA
    Int J Obes Relat Metab Disord 24:1233-8. 2000
    To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage ..
  15. pmc Interaction between the D2 dopamine receptor and neuronal calcium sensor-1 analyzed by fluorescence anisotropy
    Matthew P Woll
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Biochemistry 50:8780-91. 2011
    ..used fluorescence anisotropy (FA) and a panel of NCS-1 EF-hand variants to interrogate the interaction between the D2R and NCS-1. Our data are consistent with the following conclusions...
  16. pmc Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:14812-9. 2009
    ..An intronic single nucleotide polymorphism within the D(2) receptor gene (DRD2) (rs1076560, guanine > thymine or G > T) shifts splicing of the two protein isoforms (D(2) short, mainly ..
  17. ncbi DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients
    Todd Lencz
    Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 163:529-31. 2006
    ..The present study extends prior pharmacogenetic investigations of the D(2) receptor gene (DRD2) by examining, in first-episode schizophrenia patients, promoter region variation as a predictor of response time ..
  18. doi Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence
    Manfred Laucht
    Central Institute of Mental Health, Department of Child and Adolescent Psychiatry and Psychotherapy, P O Box 122120, D 68072 Mannheim, Germany
    J Am Acad Child Adolesc Psychiatry 47:673-81. 2008
    ..To clarify the nature of the association between dopamine genes and smoking by examining whether genetic variability in components of the dopamine pathway could explain refined phenotypes in adolescent smoking progression...
  19. ncbi Progress in searching for susceptibility loci and genes for smoking-related behaviour
    M D Li
    Program in Genomics and Bioinformatics on Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center, Floyd Curl Drive, San Antonio 78229, USA
    Clin Genet 66:382-92. 2004
    ..Of these candidate genes, the D2 dopamine receptor (DRD2) gene has been extensively studied...
  20. ncbi Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan
    Tso Jen Wang
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, ROC Tsaotun Psychiatric Center, Department of Health, Nantou, Taiwan, ROC
    Prog Neuropsychopharmacol Biol Psychiatry 31:108-14. 2007
    Both monoamine oxidase A (MAOA) and dopamine D(2) receptor (DRD2) genes have been considered as candidate genes for antisocial personality disorder with alcoholism (Antisocial ALC) [Parsian, A., 1999...
  21. ncbi Association between smoking habits and dopamine receptor D2 taqI A A2 allele in Japanese males: a confirmatory study
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:297-304. 2002
    Our previous study showed that A2 allele of dopamine D2 (DRD2) TaqI A polymorphism related to smoking habits, which was opposed to the results of studies for Caucasians...
  22. ncbi The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity
    A Southon
    Metabolic Research Unit, School of Health Sciences, Deakin University, Waurn Ponds, Victoria, Australia
    Diabetes Nutr Metab 16:72-6. 2003
    Dopamine D2 receptors (DRD2) in the central nervous system are involved in the regulation of feeding. It remains to be elucidated if mutations in the DRD2 gene contribute to the development of obesity...
  23. ncbi Heavy nicotine and alcohol use in alcohol dependence is associated with D2 dopamine receptor (DRD2) polymorphism
    Jason P Connor
    Department of Psychiatry, The University of Queensland, Princess Alexandra Hospital, Brisbane 4102, Australia
    Addict Behav 32:310-9. 2007
    ..The A1 allele of the D2 dopamine receptor (DRD2) gene has been independently associated with alcohol and nicotine dependence...
  24. pmc Association of the DRD2 gene Taq1A polymorphism and smoking behavior: a meta-analysis and new data
    Marcus R Munafo
    Department of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK
    Nicotine Tob Res 11:64-76. 2009
    Many studies have investigated the association of the dopamine type-2 receptor (DRD2) Taq1A polymorphism with tobacco use and cigarette smoking behaviors, but findings remain equivocal...
  25. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  26. doi Genetic, personality, and environmental predictors of drug use in adolescents
    Bradley T Conner
    Department of Psychology, Temple University, Philadelphia, PA 19122, USA
    J Subst Abuse Treat 38:178-90. 2010
    ..5 years) data. Variables included in the study were dopaminergic genes (ANKK1 TaqI A, DRD2 C957T, DRD4 7R, COMT Val/Met substitution, and SLC6A3 9R) and a GABAergic gene (GABRB3), all combinations of genes, ..
  27. doi Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese
    Chunming Zheng
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing 100005, China
    Neurosci Lett 518:41-4. 2012
    ..To identify whether functional variants of the D2-like receptors (DRD2, DRD3 and DRD4) confer risk of schizophrenia, we conducted a two-stage association study...
  28. pmc Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction
    D Sullivan
    Department of Pharmacology and Program in Pharmacogenomics, The Ohio State University, Columbus, OH, USA
    Transl Psychiatry 3:e222. 2013
    ..role of aberrant dopaminergic signaling, involving the dopamine transporter DAT, a cocaine target, and the dopamine D2 receptor, which physically interacts with DAT...
  29. doi Association between DRD2, 5-HTTLPR, and ALDH2 genes and specific personality traits in alcohol- and opiate-dependent patients
    Tzu Yun Wang
    Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
    Behav Brain Res 250:285-92. 2013
    ..The dopamine D2 receptor (DRD2), 5-HTT-linked promoter region (5-HTTLPR), and aldehyde dehydrogenase 2 (ALDH2) genes were genotyped ..
  30. pmc The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Ann Hum Genet 78:33-9. 2014
    ..One functional single nucleotide polymorphism in dopamine receptor D2 (DRD2), rs1076560, is involved in regulating splicing of the gene and alters the ratio of DRD2 isoforms located pre- and ..
  31. doi Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction
    C S van der Zwaluw
    Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Psychiatry 15:727-35. 2010
    Association studies investigating the link between the dopamine D2 receptor gene (DRD2) and alcohol (mis)use have shown inconsistent results. This may be due to lack of attention for environmental factors...
  32. doi Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function
    Jennifer L Bolton
    Public Health Sciences, University of Edinburgh, Medical School, Edinburgh EH9 1NN, UK
    Behav Genet 40:630-8. 2010
    ..studied the association between polymorphisms in the catechol-o-methyl transferase (COMT) and dopamine receptor D2 (DRD2) genes and general cognitive ability in a secondary analysis of 2091 men and women, aged 55-80 years living in ..
  33. pmc DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families
    Joe A Hettinger
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Behav Brain Funct 8:19. 2012
    ..Our previous findings suggest a role for dopamine-related genes in families with only affected males...
  34. doi DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents
    Igor Bombin
    Adolescent Unit, Department of Psychiatry, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Am J Med Genet B Neuropsychiatr Genet 147:873-9. 2008
    Catechol-O-methyltransferase (COMT) and dopamine receptors 2 (DRD2) and 3 (DRD3) have been associated with a higher risk of developing psychosis and with dopaminergic system (DAS) regulation...
  35. pmc Novel interaction of the dopamine D2 receptor and the Ca2+ binding protein S100B: role in D2 receptor function
    Yong Liu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Mol Pharmacol 74:371-8. 2008
    ....
  36. doi Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association study
    Pilar A Saiz
    Department of Psychiatry, School of Medicine, University of Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Julian Claveria 6, 33006, Oviedo, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 34:26-31. 2010
    To investigate the association between dopaminergic polymorphisms [DRD2 -141C Ins/Del, DRD3 Ser9Gly, and SLC6A3 VNTR] and schizophrenia.
  37. ncbi ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2
    Emma S Nyman
    National Public Health Institute, Helsinki, Finland
    J Am Acad Child Adolesc Psychiatry 46:1614-21. 2007
    ..This study tests a series of allelic variants within such candidate genes to determine their potential influence on ADHD susceptibility...
  38. doi Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Cneter, Durham, NC 27708, USA
    Nicotine Tob Res 10:117-27. 2008
    ..Polymorphisms in the DRD2 gene and, among females, the MAOA gene interacted with retrospective reports of ADHD symptoms in contributing to ..
  39. doi Association study of three polymorphisms in the dopamine D2 receptor gene and schizophrenia in the Russian population
    Mikhail Monakhov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova 32, 119991 Moscow, Russia
    Schizophr Res 100:302-7. 2008
    Polymorphisms in the dopamine D2 receptor gene (DRD2) have repeatedly been associated with schizophrenia...
  40. doi Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder
    Caroline Davis
    Kinesiology and Health Sciences, York University, Toronto, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 32:620-8. 2008
    ..The present study addressed this issue by implementing psychological and biological markers of reward sensitivity in the assessment protocol...
  41. doi Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..The dopamine receptor D(2) (DRD2) protein and dopamine transporter (DAT1) protein play regulatory roles in dopamine neurotransmission...
  42. ncbi D(2) dopamine receptor (DRD2) polymorphism is associated with severity of alcohol dependence
    J P Connor
    Department of Psychiatry, University of Queensland, Australia
    Eur Psychiatry 17:17-23. 2002
    The A(1) allele of the D(2) dopamine receptor (DRD2) gene has been associated with alcohol dependence...
  43. ncbi Sexually dimorphic link between dopamine D2 receptor gene and neuroticism-anxiety
    Jan Wacker
    Department of Psychology, University of Marburg, 35032 Marburg, Germany
    Neuroreport 16:611-4. 2005
    ..Here, we examined the association between the dopamine D2 receptor (DRD2) TaqI A polymorphism and two other personality traits, neuroticism-anxiety and agentic extraversion...
  44. ncbi The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years
    Ivo Paclt
    Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic
    Neuro Endocrinol Lett 31:131-6. 2010
    The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene...
  45. ncbi Dopamine D2 receptor dimer formation: evidence from ligand binding
    D Armstrong
    School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
    J Biol Chem 276:22621-9. 2001
    ..A model of the receptor has been produced that provides a good description of the experimental phenomena described here...
  46. ncbi Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors
    Joelle Hillion
    Department of Neuroscience, Karolinska Institute, 17177 Stockholm, Sweden
    J Biol Chem 277:18091-7. 2002
    ..These results give a molecular basis for adenosine-dopamine antagonism at the membrane level and have implications for treatment of Parkinson's disease and schizophrenia, in which D(2)R are involved...
  47. ncbi Dopamine gene predicts the brain's response to dopaminergic drug
    Michael X Cohen
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    Eur J Neurosci 26:3652-60. 2007
    ..Ten subjects had an allele on the Taq1A DRD2 gene, which is associated with reduced dopamine receptor concentration and decreased neural responses to rewards (..
  48. pmc Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence
    San Yuan Huang
    Department of Psychiatry, Tri Service General Hospital, Taiwan, ROC
    J Psychiatry Neurosci 32:185-92. 2007
    ..Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.
  49. ncbi Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review
    Lesley Smith
    School of Health and Social Care, Oxford Brookes University, Marston, United Kingdom
    Am J Epidemiol 167:125-38. 2008
    ..The relatively small effect for the association of the A1 allele, or another genetic variant linked to it, with alcohol dependence indicates a multigene causality for this complex disorder...
  50. ncbi C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
    M Hirvonen
    Mol Psychiatry 9:1060-1. 2004
  51. ncbi Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR
    G E Swan
    Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA
    Pharmacogenomics J 5:21-9. 2005
    The A1 allele of the dopamine D2 receptor gene (DRD2) is associated with a reduced number of dopamine binding sites in the brain and with the increased likelihood of substance abuse and addictive behavior...
  52. ncbi An affected pedigree member analysis of linkage between the dopamine D2 receptor gene TaqI polymorphism and obesity and hypertension
    Yu Jing Fang
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Int J Cardiol 102:111-6. 2005
    ..We have previously reported that the TaqI polymorphism of the dopamine D2 receptor (DD2R) gene is associated with both blood pressure and obesity indices in a normoglycaemic Hong Kong ..
  53. ncbi P300 development during adolescence: effects of DRD2 genotype
    Steven M Berman
    Department of Psychiatry and Biobehavioral Sciences, Alcohol Research Center, University of California, Los Angeles, CA 90024, USA
    Clin Neurophysiol 117:649-59. 2006
    ..The present study examined whether the change in P300 amplitude during adolescence in sons of alcoholics and nonalcoholics is affected by D2 dopamine receptor (DRD2) polymorphism.
  54. ncbi Genetically determined differences in learning from errors
    Tilmann A Klein
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Science 318:1642-5. 2007
    ..outcomes and feedback-based learning was tested in a neuroimaging study in humans grouped according to the dopamine D2 receptor gene polymorphism DRD2-TAQ-IA...
  55. doi Interaction between DRD2 C957T polymorphism and an acute psychosocial stressor on reward-related behavioral impulsivity
    Melanie J White
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, QLD, Australia
    Behav Genet 39:285-95. 2009
    The dopamine D2 receptor (DRD2) C957T polymorphism CC genotype is associated with decreased striatal binding of DRD2 and executive function and working memory impairments in healthy adults...
  56. doi Dopamine for "wanting" and opioids for "liking": a comparison of obese adults with and without binge eating
    Caroline A Davis
    Department of Kinesiology and Health Sciences, Faculty of Health, York University, Toronto, Ontario, Canada
    Obesity (Silver Spring) 17:1220-5. 2009
    ..We targeted three functional polymorphisms related to the D2 receptor (DRD2) gene, as well as the functional A118G polymorphism of the mu-opioid receptor (OPRM1) gene...
  57. pmc Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia
    M Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neurology 72:2097-103. 2009
    ..To determine whether changes in D(2) receptor availability are present in carriers of genetic mutations for primary dystonia...
  58. pmc Human cognitive flexibility depends on dopamine D2 receptor signaling
    Mieke van Holstein
    Donders Institute for Brain, Cognition and Behaviour RU DI BCB, Radboud University Nijmegen, Kapittelweg 29, 6521 EN Nijmegen, The Netherlands
    Psychopharmacology (Berl) 218:567-78. 2011
    ..In particular, recent work with animals as well as current theorizing has suggested that cognitive flexibility depends on dopamine D2 receptor signaling. However, there is no evidence for similar mechanisms in humans.
  59. doi Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes
    Caroline Davis
    Kinesiology and Health Sciences, York University, Toronto, Canada M3J1P3
    Prog Neuropsychopharmacol Biol Psychiatry 38:328-35. 2012
    ..We investigated the D2 receptors genes (DRD2/ANKK1) and their relation to the BED phenotype and four sub-phenotypes of BED that reflect an enhanced response to ..
  60. ncbi Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor
    G Sarkar
    Department of Biochemistry and Molecular Biology, Mayo Clinic Foundation, Rochester, Minnesota 55905
    Genomics 11:8-14. 1991
    The dopamine D2 receptor gene (gene symbol DRD2) is a candidate gene for schizophrenia because the potency of certain neuroleptics correlates with their affinity for this receptor...
  61. ncbi Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal
    Samuel P Lee
    Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 279:35671-8. 2004
    ....
  62. ncbi The genetic basis for smoking behavior: a systematic review and meta-analysis
    Marcus Munafo
    Department of Clinical Pharmacology, University of Oxford, UK
    Nicotine Tob Res 6:583-97. 2004
    ..The meta-analysis included data on the DRD2, DAT, 5HTT, and CYP2A6 genes and smoking behavior...
  63. ncbi Dopamine receptor D2 gene polymorphisms are associated in Taiwanese children with Tourette syndrome
    Cheng Chun Lee
    Department of Neurology, China Medical University Hospital, Taichung, Taiwan
    Pediatr Neurol 33:272-6. 2005
    ..Polymerase chain reaction was used to identify the Taq I DRD2 and DRD2 (H313H) polymorphisms of the dopamine receptor D2 gene...
  64. pmc The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study
    Mindi A Styn
    Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 150:254-61. 2009
    ..and smoking cessation by examining associations with a variable number tandem repeat variation in SLC6A3 and the DRD2 variants TaqIA (A2 vs. A1), TaqIB (B2 vs. B1), C957T (C vs. T), and -141C Ins/Del (C vs. Del)...
  65. pmc Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance
    Christian Montag
    Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1860-7. 2010
    ..SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, ..
  66. ncbi No association between dopamine D2 receptor gene (DRD2) and human intelligence
    H W Moises
    Department of Psychiatry, Kiel University Hospital, Federal Republic of Germany
    J Neural Transm (Vienna) 108:115-21. 2001
    ..The dopamine D2 receptor gene (DRD2) was chosen as a candidate gene for general cognitive ability (g) since it has been found to be ..
  67. ncbi Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese
    K Yoshida
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 10:403-5. 2001
    For the study presented here, we investigated possible links between the dopamine D2 receptor (DRD2) TaqIA genotype (DRD2*A) and smoking behavior in a total of 332 Japanese individuals...
  68. ncbi Impulsiveness as the intermediate link between the dopamine receptor D2 gene and alcohol dependence
    F Limosin
    Department of Psychiatry, Albert Chenevier Hospital, Creteil, France
    Psychiatr Genet 13:127-9. 2003
    ..an intermediate link between the risk for alcohol dependence and the gene coding for the dopamine receptor D2 (DRD2)...
  69. ncbi ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles
    Tamiko Konishi
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA, USA
    Alcohol Clin Exp Res 28:1145-52. 2004
    ..The genes selected include alcohol metabolizing genes and neurotransmitter genes, which have been shown in the literature to be associated with alcoholism in other ethnic groups...
  70. ncbi Family-based and case-control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence
    Jerzy Samochowiec
    Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71 460 Szczecin, Poland
    Neurosci Lett 410:1-5. 2006
    ..that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause ..
  71. pmc Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study
    Dan T A Eisenberg
    State University of New York at Binghamton, Biology Department, Binghamton, NY, USA
    Behav Brain Funct 3:2. 2007
    ..This study examined the relationship between possession of the DRD2 TaqI A and DRD4 48 bp VNTR genetic polymorphisms and performance on a behavioral measure of impulsivity, the delay ..
  72. doi Polymorphism in environment responsive genes and association with Parkinson disease
    Madhu Singh
    Developmental Toxicology Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Mol Cell Biochem 312:131-8. 2008
    ..in genotype and allele frequencies was observed for manganese-superoxide dismutase (MnSOD), dopamine receptor-D2(DRD2), and dopamine transporter (DAT) genes between controls and PD cases...
  73. doi Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: a critical evaluation of the single-scan approach
    Philipp T Meyer
    Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany
    Neuroimage 42:548-58. 2008
    ..The present study addresses these shortcomings...
  74. doi C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo
    Mika M Hirvonen
    Department of Pharmacology, Drug Development and Therapeutics, University of Turku, 20014 Turku, Finland
    Prog Neuropsychopharmacol Biol Psychiatry 33:630-6. 2009
    The C957T (rs6277) single nucleotide polymorphism (SNP) of the human dopamine D2 receptor (DRD2) gene (DRD2) affects DRD2 mRNA stability and has been shown to predict striatal DRD2 availability (B(max)/K(D)) in vivo in man...
  75. ncbi Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23
    J H Eubanks
    Molecular Genetics Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Genomics 14:1010-8. 1992
    The gene encoding the D2 dopamine receptor (DRD2) is located on human chromosome 11q23 and has been circumstantially associated with a number of human disorders including Parkinson's disease, schizophrenia, and susceptibility to ..
  76. ncbi Dopamine receptors: from structure to function
    C Missale
    Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Physiol Rev 78:189-225. 1998
    ..However, targeted deletion of several of these dopamine receptor genes in mice should provide valuable information about their physiological functions...
  77. ncbi Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein
    F D Smith
    Department of Cell and Molecular Physiology and the Curriculum in Neurobiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:19894-900. 1999
    ..We hypothesize that spinophilin is important for establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors to downstream signaling molecules and the actin cytoskeleton...
  78. ncbi Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorder
    R B Lu
    Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Alcohol Clin Exp Res 25:177-84. 2001
    ..disorder and alleles of the TaqI A and TaqI B polymorphisms, both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2)...
  79. ncbi The -141C Ins/Del polymorphism of the dopamine D2 receptor gene is not associated with either migraine or Parkinson's disease
    S Maude
    Department of Mental Health, Medical School, University of Aberdeen, UK
    Psychiatr Genet 11:49-52. 2001
    Abnormalities in dopamine neurotransmission at the dopamine D2 receptor (DRD2) have been implicated in both migraine and Parkinson's disease...
  80. ncbi G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase
    Natalie Lavine
    Centre for Addiction and Mental Health, Department of Pharmacology, Institute of Medical Science, University of Toronto, Ontario M5T 1R8, Canada
    J Biol Chem 277:46010-9. 2002
    ..The observation that several G protein-coupled receptors form stable complexes with their effectors suggests that this arrangement might be a general feature of G protein-coupled signal transduction...
  81. ncbi Association and linkage disequilibrium between a functional polymorphism of the dopamine-2 receptor gene and schizophrenia in a genetically homogeneous Portuguese population
    K M Schindler
    Center for Psychiatric and Molecular Genetics, SUNY Upstate Medical University and Behavioral Health Care Line, VISN 2, Veterans Administration, Syracuse, New York, USA
    Mol Psychiatry 7:1002-5. 2002
    A functional polymorphism in the promoter region of the DRD2 gene has been found to be associated with schizophrenia in Japanese(1,2) and Swedish populations...
  82. ncbi D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes
    Ernest P Noble
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 116:103-25. 2003
    The D2 dopamine receptor (DRD2) has been one of the most extensively investigated gene in neuropsychiatric disorders...
  83. ncbi Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis
    M R Munafò
    Cancer Research UK GPRG, Institute of Health Sciences, University of Oxford, Oxford, UK
    Mol Psychiatry 8:471-84. 2003
    ..data using a fixed-effects model suggested significant associations between the 5HTT LPR, DRD4 c>t, DRD4 length, DRD2 A1/A2, DRD3 A1/A2 polymorphisms and personality traits...
  84. ncbi Meta-analysis identifies an association between the dopamine D2 receptor gene and schizophrenia
    S J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, MA 02115, USA
    Mol Psychiatry 8:911-5. 2003
    ..Early evidence supporting an association between the Cys311Ser polymorphism of the D2 receptor gene (DRD2) and schizophrenia was subsequently refuted and, eventually, dismissed...
  85. pmc Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors
    Freddy Jeanneteau
    Unité de Neurobiologie et Pharmacologie Moléculaire INSERM U 573, Centre Paul Broca, 75014 Paris, France
    Mol Biol Cell 15:696-705. 2004
    ..Through its dimerization, GIPC acts as a selective scaffold protein to assist receptor functions. Our results suggest a novel function for GIPC in the maintenance, trafficking, and signaling of GPCRs...
  86. ncbi Stress-induced cigarette craving: effects of the DRD2 TaqI RFLP and SLC6A3 VNTR polymorphisms
    J Erblich
    Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Pharmacogenomics J 4:102-9. 2004
    ..Significantly stronger stress-induced cigarette craving was found for individuals carrying either the DRD2 (D2 dopamine receptor gene) A1, or the SLC6A3 (dopamine transporter gene) nine-repeat allelic variants...
  87. ncbi Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers
    M R Munafò
    Cancer Research UK General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Pharmacogenomics J 5:96-101. 2005
    An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample...
  88. ncbi Genetic influences on quantity of alcohol consumed by adolescents and young adults
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C 268 35, Denver, CO 80262, USA
    Drug Alcohol Depend 78:187-93. 2005
    ..To examine genetic and environmental influences on drinking in a nationally representative study of genetically informative adolescents followed into young adulthood...
  89. ncbi The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects
    Aki Laakso
    Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku University Central Hospital, Turku, Finland
    Pharmacogenet Genomics 15:387-91. 2005
    The A1 allele of the TaqI restriction fragment length polymorphism (RFLP) of the human dopamine D2 receptor gene (DRD2) is associated with a low density of D2 dopamine receptors in the striatum...
  90. ncbi Polymorphisms in the DBH and DRD2 gene regions and smoking behavior
    Maria Teresa M V Freire
    Departamento de Genetica, Instituto de Biociencias, UFRGS, Av Bento Goncalves, 9500, Porto Alegre, RS, 91501 970, Brazil
    Eur Arch Psychiatry Clin Neurosci 256:93-7. 2006
    The DRD2 TaqI A and DBH-1021 C/T polymorphisms were genotyped in smoking alcoholics (N = 100), non-alcoholic smokers (N = 120) and nonsmoking controls (N = 112)...
  91. ncbi Lack of effect of D2 dopamine receptor TaqI A polymorphism on smoking cessation
    Ivan Berlin
    Departement de Pharmacologie, Groupe Hospitalier Universitaire Pitié Salpêtrière, Paris, France
    Nicotine Tob Res 7:725-8. 2005
    ..2004] Nicotine & Tobacco Research, 6, 229-239) found that the D2 dopamine receptor (DRD2) TaqI A polymorphism was associated with smoking cessation: Carriers of the A1 allele were less likely to quit than ..
  92. ncbi No association of dopamine receptor sensitivity in vivo with genetic predisposition for alcoholism and DRD2/DRD3 gene polymorphisms in alcohol dependence
    Gerhard A Wiesbeck
    Division of Substance Use Disorders, Psychiatric University Hospital Basel, Switzerland
    Addict Biol 11:72-5. 2006
    ..in vivo and to explore whether this sensitivity might be associated with functional variations of dopamine D2 (DRD2) and D3 (DRD3) receptor genes along with a genetic predisposition for alcoholism as reflected by an alcohol-..
  93. ncbi Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward
    Peter Kirsch
    Center for Psychiatry, Justus Liebig University Giessen, Am Steg 28, D 35385 Giessen, Germany
    Neurosci Lett 405:196-201. 2006
    ..The DRD2 TaqIA polymorphism is associated with dopamine D2 receptor density which plays an important role in the context of reward...
  94. ncbi Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Hum Mol Genet 15:3498-507. 2006
    ..97) for ND in the EA part of the sample on chromosome 11q23, a region that includes the NCAM1-TTC12-ANKK1-DRD2 gene cluster...
  95. ncbi DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
    Lindsay M Morton
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Pharmacogenet Genomics 16:901-10. 2006
    ..We investigated the association between smoking behavior and genetic variations in the D2 dopamine receptor (DRD2), which mediates nicotine dependence...
  96. pmc D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum
    Asim J Rashid
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Proc Natl Acad Sci U S A 104:654-9. 2007
    ....
  97. ncbi D1 and D2 dopamine receptor expression is regulated by direct interaction with the chaperone protein calnexin
    R Benjamin Free
    Molecular Neuropharmacology Section, NINDS, National Institutes of Health, Bethesda, Maryland 20892 9405, USA
    J Biol Chem 282:21285-300. 2007
    ..Our data suggest that optimal receptor-calnexin interactions critically regulate D(1) and D(2) receptor trafficking and expression at the cell surface, a mechanism likely to be of importance for many GPCRs...
  98. ncbi Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors
    David J Vandenbergh
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802 2321, USA
    Addict Biol 12:106-16. 2007
    Cigarette smoking, like many addictive behaviors, has a genetic component, and the dopamine D2-like receptor genes (DRD2, DRD3 and DRD4) are candidates for contributing to these behaviors...
  99. ncbi Polymorphisms in dopamine receptor DRD1 and DRD2 genes and psychopathological and extrapyramidal symptoms in patients on long-term antipsychotic treatment
    Vita Dolzan
    Institute of Biochemistry, Faculty of Medicine, Ljubljana, Slovenia
    Am J Med Genet B Neuropsychiatr Genet 144:809-15. 2007
    ..interaction between genetic and clinical factors, we studied the possible cross-interactions between DRD1 and DRD2 dopamine receptor gene polymorphisms, symptomatology of schizophrenia and schizoaffective disorders, and the ..
  100. ncbi D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals
    U W Preuss
    Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
    Alcohol Alcohol 42:258-66. 2007
    ....
  101. pmc Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families
    Shirley Y Hill
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 147:517-26. 2008
    Animal and human studies of addiction indicate that the D2 dopamine receptor (DRD2) plays a critical role in the mechanism of drug reward. D2 receptor density in the brains of alcoholics has been shown to be reduced relative to controls...

Research Grants67

  1. Anissa Abi-Dargham; Fiscal Year: 2014
    ..with schizophrenia but we know little about the underlying mechanistic involvement of dopamine D2 receptors (D2R) in the illness...
  2. Marc G Caron; Fiscal Year: 2016
    ..main projects: Project #1: Will deliver beta-arrestin-biased agonist clinical candidates of dopamine D2 receptors (D2R) for the treatment of schizophrenia and related disorders, and create novel D2R ligands with a wide range of ..
  3. IAN THOMAS ELLWOOD; Fiscal Year: 2015
    ..Additionally, dysfunction of the D2R system has been hypothesized to underlie a number of psychiatric diseases, most notably schizophrenia, and D2Rs are ..
  4. Genetics and Haloperidol Response
    Robert J Hitzemann; Fiscal Year: 2012
    ..The core working hypothesis is that response and non-response are regulated by the coherence level of the dopamine D2 receptor (Drd2) gene network. The research plan contains four specific aims...
  5. Christoph Kellendonk; Fiscal Year: 2016
    ..Specifically, the project proposes to take advantage of a genetic mouse model of dopamine D2 receptor up-regulation in MSNs that is associated with a deficit in motivation...
  6. Relating GPCRs by biased ligands for enhanced therapeutic efficacy
    MICHAEL JAMES KEISER; Fiscal Year: 2013
    ..Starting with the Gi-coupled dopamine D2 receptor (D2R), we will predict biased ligands, evaluating our methods both retrospectively and via prospective ..
  7. Fu Ming Zhou; Fiscal Year: 2014
    The dopamine D2 receptor (D2R)-expressing medium spiny neurons (D2-MSN) in the striatum project to the GABAergic neurons in the globus pallidus (GP), forming an important link in the basal ganglia motor control circuit...
  8. David M Lyons; Fiscal Year: 2014
    ..evidence further suggests that early exposure to social stress induces long-lasting downregulation of dopamine D2 receptor (DRD2) gene expression in ventral but not dorsal striatum...
  9. Laurie J Ozelius; Fiscal Year: 2016
    ..g. cerebellum and cortex, are also involved. Within the basal ganglia, the focus has been on the dopamine D2 receptor (D2R) and striatal cholinergic interneurons...
  10. Novel tools for identifying GPCR compounds modulating specific sub-cellular ERK a
    Haifeng Eishingdrelo; Fiscal Year: 2013
    ..Brain-derived dopamine D2 receptor-regulated behaviors have been associated to ERK activation...
  11. Biased Attention to Emotional Faces as an Endophenotype Predicting Depression
    JESSICA LYNNE JENNESS; Fiscal Year: 2013
    ..candidate genes: the serotonin transporter gene (5-HTTLPR), catechol-o- methyl-transferase gene (COMT), and dopamine D2 receptor gene (DRD2)...
  12. Behavioral Genetics of Mood-Induced Smoking
    KENNETH ALAN PERKINS; Fiscal Year: 2010
    ..These include: dopamine D4 receptor (DRD4 VNTR), dopamine D2 receptor (DRD2 C957T SNP [rs6277] and DRD2/ANKK1 TaqIA SNP [rs1800497]), the dopamine transporter (SLC6A3 VNTR), and ..
  13. Cortical Mechanisms of Cocaine Sensitization
    Jeffery D Steketee; Fiscal Year: 2012
    ..Furthermore, dopamine D2 receptor (D2R) function appears to be decreased in cocaine sensitized animals...
  14. Gene x Environment Interactions Predicting an Endophenotype for Depression
    Caroline Oppenheimer; Fiscal Year: 2012
    ..selected and theoretically motivated candidate genes: the serotonin transporter gene (5-HTTLPR), the dopamine D2 receptor gene (DRD2), and monoamine oxidase A (MAOA)...
  15. Presynaptic versus postsynaptic functions of dopamine D2 receptors in the respons
    Emiliana Borrelli; Fiscal Year: 2012
    ..The dopamine D2 receptor (D2R) is a key component of the dopaminergic system...
  16. Michelle M Jacobs; Fiscal Year: 2016
    ..Specifically, I will fully study the two main genes of interest, dopamine D1 receptor and dopamine D2 receptor (DRD1 and DRD2, respectively), using next-generation sequencing technologies in 100 newly recruited HIV-..
  17. Paolo Sassone-Corsi; Fiscal Year: 2014
    ..This application is focused on one principal element of the dopaminergic system, the dopamine D2 receptor (D2R)...
  18. ADENOSINE /DOPAMINE INTERACTIONS IN A2A RECEPTOR KO MICE
    Jiang Fan Chen; Fiscal Year: 2002
    DESCRIPTION (from applicant's abstract): The adenosine A2a receptor (A2aR) is co-expressed with the dopamine D2 receptor (D2R) in striatopallidal neurons and exerts an antagonistic influence on postsynaptic D2R function in brain...
  19. The Influence of Dopaminergic Genetic Variants on D2-like Receptors in Drinkers
    Amira K Brown; Fiscal Year: 2011
    ..Considerable evidence links dopaminergic genetic markers like the DRD2 TaqIA polymorphism, which modulates the function and/or expression of dopamine receptors, to the increased risk for ..
  20. POSITRON EMISSION TOMOGRAPHY INVESTIGATIONS OF DYSTONIA
    Joel Perlmutter; Fiscal Year: 1999
    ..dystonia) and the hand (hand cramp) as well as normals using positron emission tomography and a new dopamine D2 receptor radioligand, [18F]NMB...
  21. Individual differences in stimulant reinforcement as a function of DRD2 allele
    Stacey C Sigmon; Fiscal Year: 2010
    ..What has not been examined to our knowledge is how individuals, prospectively identified as DRD2 A1 allele carriers or noncarriers, may differ in their sensitivity to the reinforcing effects of stimulants...
  22. Polymorphisms Related to Dopamine Receptor Function and Smoking
    ERIC CHRISTIAN DONNY; Fiscal Year: 2010
    ..to utilize established human laboratory procedures and functional neuroimaging to rigorously assess the impact of DRD2/ANKK1 Taq IA and DRD4 VNTR polymorphisms on the processing of both smoking and non-smoking rewards, and ultimately, ..
  23. Development of A Novel Animal Model of Tardive Dyskinesia
    Abraham Kovoor; Fiscal Year: 2010
    ..is understood other than that a necessary factor is the chronic blockade of D2- like dopamine receptors (D2R) expressed in the striatum...
  24. Jonathan A Javitch; Fiscal Year: 2016
    ..as well as DA D2 receptor binding potential, are altered in the striatum of patients with schizophrenia, and D2R antagonism remains the unifying property of all current antipsychotic drugs...
  25. Relation of Consummatory and Anticipatory Food Reward to Obesity
    Sonja Yokum; Fiscal Year: 2013
    ..These relations were more pronounced for adolescents with the A1 allele of the TaqIA DRD2 gene, which is associated with reduced D2 receptor density and compromised dopamine signaling in the striatum...
  26. Prenatal Cannabis Exposure and Epigenetic Mechanisms Underlying Vulnerability to
    CLAUDIA VARGAS MORRIS; Fiscal Year: 2013
    ..both our unique human fetal brain collection and rat model show a significant decrease in dopaminergic D2 receptor (Drd2) gene expression in the NAc folowing prenatal cannabis/THC exposure...
  27. ALCOHOL PHARMACOGENETICS IN MEXICAN AMERICANS
    YU JUI WAN; Fiscal Year: 2009
    ..a relatively high rate of ADH3*2 and CYP2E1 c2 (cytochrome P4502E1) alleles;(3) association of ADH3*2, ADH2*1, DRD2 (dopamine receptor -141C Del/Ins) and serotonin transporter gene-linked polymorphic region (5-HTTLPR) with ..
  28. Akt/GSK-3 Signaling Cascade and the Actions of Dopamine
    Marc G Caron; Fiscal Year: 2011
    ..Our previous work has demonstrated that in the striatum, DA D2 receptors (D2R) mediate some of their actions through the Akt/GSK3 signaling pathway in a G protein-independent fashion via ..
  29. Marc G Caron; Fiscal Year: 2016
    ..Our previous work has demonstrated that in the striatum, DA D2 receptors (D2R) mediate some of their actions through the Akt/GSK3 signaling pathway in a G protein-independent fashion via ..
  30. Generate and Characterize Knock-In Mice Harboring DRD2 Ser311Cys Polymorphism
    Ya Ping Tang; Fiscal Year: 2010
    ..the widely accepted "dopamine hypothesis" for schizophrenia, polymorphism of Ser311Cys in the dopamine receptor-2 (DRD2) gene should be an important subject for further studies...
  31. Functional Characterization of ANKK1 and its Genetic Variants
    Weihua Huang; Fiscal Year: 2010
    Genetic studies have yielded conflicting results as to whether DRD2-Taq IA polymorphism is associated with addiction as well as other neurobiological traits and neuropsychiatric disorders...
  32. PKC-beta Regulation of the Dopmaine Transporter Trafficking
    Rong Chen; Fiscal Year: 2010
    ..trafficking/activity seems to involve two other DAT directly interacting proteins RACK1 and D2 dopamine receptor (D2R)...
  33. Receptor trafficking profiles of clinically important dopaminergic drugs
    Jennifer L Whistler; Fiscal Year: 2013
    ..D1-like receptors (D1R and D5R) are Gs-coupled excitatory GPCRs, while D2-like receptors (D2R, D3R and D4R) are Gi-coupled inhibitory GPCRs...
  34. Wolfgang Sadee; Fiscal Year: 2014
    ..enzymes and receptors, gaining a powerful link between genotype of proven function and clinical outcomes (examples: DRD2, TPH2, ACE, VKORC1, CETP, and CYP3A4)...
  35. Neuronal mRNA PET Imaging
    Eric Wickstrom; Fiscal Year: 2010
    ..Cocaine, which binds to the dopamine receptor 2 (D2R), is the most widely abused drug...
  36. Bio-Behavioral Smoking Profiles in Mexican Origin Youth
    ANNA VICTORIA WILKINSON; Fiscal Year: 2012
    ..sensation-seeking tendencies, participation in physical activities, and by completing additional genotyping on DRD2, DRD4, and the dopamine transporter gene...
  37. DIPAK KUMAR SARKAR; Fiscal Year: 2015
    ..Recent studies in animals have identified a role for dopamine receptor 2 (D2R) in mediating the inhibitory control of hypothalamic dopamine on prolactin-secreting lactotropes in the pituitary...
  38. Paul J Lombroso; Fiscal Year: 2015
    ..We predict that dopamine D2R antagonists activate PKA, leading to the phosphorylation and inactivation of STEP61...
  39. Transporter Mechanism of Amphetamine Sensitization
    Rong Chen; Fiscal Year: 2011
    ..DAT trafficking is primarily induced by DAT substrate (e.g. AMPH) and D2R agonist (e.g. quinpirole)...
  40. Anthony J Baucum; Fiscal Year: 2016
    ..of the medium spiny neuron (MSN) that express either D1 dopamine receptors or D2 dopamine receptors (D1R and D2R, respectively)...
  41. Anthony M Zador; Fiscal Year: 2014
    ..For example, neurons defined by the expression of the D1R and D2R dopamine receptors represent distinct neuronal subpopulations which play distinct roles in reinforcement learning ..
  42. Baoji Xu; Fiscal Year: 2014
    ..MSNs are divided into two populations: those expressing the dopamine receptor D2 (DRD2) in the indirect pathway and those expressing the dopamine receptor D1a (DRD1a) in the direct pathway...
  43. Specifying Human iPSC-derived Medium spiny Neurons for Cocaine Abuse Research
    Xin Ming Ma; Fiscal Year: 2012
    ..MSNs will be identified by immunostaining with antibodies specific DARPP32, GABA and dopamine receptors (D1R and D2R)...
  44. The Histone Demethylase SMCX/JARED1C as a Therapeutic Target for Huntington's Dis
    Leslie Michels Thompson; Fiscal Year: 2012
    ..Other neuronal genes such as the dopamine receptor 2 (DRD2) and preproenkephalin (PPE) are reproducibly decreased in mRNA expression levels early in HD and the reduced ..
  45. Dopaminergic Neurons from Pluripotent Stem Cells for Substance Abuse Research
    Pietro P Sanna; Fiscal Year: 2012
    ..and CHRNA6, the A118G polymorphism of the [unreadable] opioid receptor OPRM1, and mutations in the TTC12-ANKK1- DRD2, among others...
  46. Roles of BDNF in Striatal Neurons and Relevance to Huntington's Disease
    Baoji Xu; Fiscal Year: 2010
    ..MSNs are divided into two populations: those expressing the dopamine receptor D2 (DRD2) in the indirect pathway and those expressing the dopamine receptor D1a (DRD1a) in the direct pathway...
  47. Genetic basis of smoking abstinence, smoking reinforcement, and inhibitory contro
    Scott H Kollins; Fiscal Year: 2010
    ..work will systematically extend work conducted by the investigative team showing that 1) genetic variation in the DRD2 gene is associated with differential levels of IC;2) smoking abstinence causes significant disruptions in IC;and 3) ..
  48. Genetic and Epigenetic Regulation of Addiction Genes
    Wolfgang Sadee; Fiscal Year: 2010
    ..enzymes, vesicular and synaptic reuptake transporters, and receptors (MAOA, MAOB, COMT, TH, DAT, NET, VMAT2, DRD2, CHRNA4)...
  49. A novel rodent model of dopamine agonist-induced impulsive control disorders
    T Celeste Napier; Fiscal Year: 2012
    ..PPX and ROP activate all receptors in the D2R family;however both have slightly higher affinity for the D3R subtype, which is highly expressed in reward regions ..
  50. Multi-level Modular Agent-based Modeling for the Study of Childhood Obesity
    LAURETTE DUBE; Fiscal Year: 2010
    ..interactions influencing eating behaviors and body weight (BMI): (1) genetics (dopaminergic gene systems DRD2 DRD4);(2) neurobiology (dopamine-striatal and executive control functions);(3) psychological predisposition (..
  51. Multi-level Modular Agent-based Modeling for the Study of Childhood Obesity
    LAURETTE DUBE; Fiscal Year: 2013
    ..interactions influencing eating behaviors and body weight (BMI): (1) genetics (dopaminergic gene systems DRD2 DRD4);(2) neurobiology (dopamine-striatal and executive control functions);(3) psychological predisposition (..
  52. 18F-Fallypride Micropet Imaging to Monitor Pancreatic Beta Cell Loss in Diabetes
    Adriana Garcia; Fiscal Year: 2010
    ..Adriana will test the hypothesis that PET-CT scanning with 18F-fallypride, a radioligand for D2 receptors (D2R) for dopamine, can document [unreadable]-cell loss associated with T1DM...
  53. Regulation of ethanol intake by prior feeding:D2 autoinhibition in VTA
    Linzy M Hendrickson; Fiscal Year: 2012
    ..food consumption, many studies have found decreases in basal and evoked DA release as well as decreases in DA D2 (D2R) receptor expression in the NAc and dorsal striatum in both animal models and in obese human subjects (reviewed in (..
  54. Kent A Kiehl; Fiscal Year: 2014
    ..cocaine-dependent and matched healthy participants for investigation of dopamine transporter (SLC6A3) and receptor (DRD2 and DRD4) genotypes...
  55. D2 Receptor and Food Restriction Regulation of Dopamine Release by Amphetamine
    Kevin Erreger; Fiscal Year: 2010
    ..Using animal model and pharmacological approaches it has been shown that D2 DA receptors (D2R) regulate the rewarding effects of AMPH...
  56. Mark E Wilson; Fiscal Year: 2015
    ..to chronic psychosocial stress increases susceptibility to an addictive phenotype by reducing DA 2 receptors (D2R) in mesolimbic regions, producing a hypodopaminergic condition...
  57. Zachary Freyberg; Fiscal Year: 2015
    ..faster and this is dependent both on presynaptic dopamine transporter and postsynaptic dopamine (DA) D2 receptors (D2R)...
  58. Genetic Polymorphism of a Schizophrenia Endophenotype
    Ikwunga Wonodi; Fiscal Year: 2007
    ..In an exploratory framework, we will examine variations in other candidate dopamine genes, the dopamine 2 receptor (DRD2) and the dopamine .3 receptor (DRD3) genes...
  59. cAMP mediation of drug and social reward
    KIMBERLY ANNE YOUNG; Fiscal Year: 2010
    ..Specifically, D2 receptor (D2R) activation (and the corresponding decrease in cAMP activity) facilitates, and D1 receptor (D1R) activation (and ..
  60. Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression
    Deveroux Ferguson; Fiscal Year: 2013
    ..the effects of social defeat on sirtuin signaling in a cell type specific manner in the NAc using drd1-GFP and drd2-GFP transgenic mice, allowing for the identification of striatonigral and striatopallidal medium spiny neurons (..
  61. Generate and Characterize Knock-In Mice Harboring DRD2 Ser311Cys Polymorphism
    Ya Ping Tang; Fiscal Year: 2009
    ..the widely accepted "dopamine hypothesis" for schizophrenia, polymorphism of Ser311Cys in the dopamine receptor-2 (DRD2) gene should be an important subject for further studies...
  62. Gene x Environment Factors in Smoking Cessation
    Andrew Hyland; Fiscal Year: 2007
    ..Our primary aim is to examine patterns of tobacco use in relation to genetic factors including the following genes: DRD2 and DRD4 (dopamine receptor); SLC6A3 (dopamine transporter); DBH, COMT, MAOA (dopamine metabolism); 5-HTT (..
  63. Pluripotent Adult Spermatogonial Stem Cells: Prospective for Retinal Degeneration
    Nady Golestaneh; Fiscal Year: 2010
    ..expressing neuronal specific markers, such as, nestin, neurofilament, synaptophysin and dopaminergic receptor 2 (Drd2)...
  64. Cumulative Genetic and Environmental Predictors of Youth Substance Use
    JENNIFER LYNN CARRANO; Fiscal Year: 2012
    ..biologically- and empirically-supported genetic risk polymorphisms in the dopaminergic system (measured in the DRD2, DRD4, DAT1, and MAO-A genes);(b) cumulative environmental risk;and (c) cumulative environmental promotive factors ..
  65. NATHANIEL ERIK ANDERSON; Fiscal Year: 2015
    ..Specifically, 5HTT, MAOA, DAT, DRD2, and DRD4 are featured prominently in this literature and impact monoaminergic signaling pathways responsible for ..
  66. GENETIC FACTORS IN THE MODULATION OF MOOD BY NICOTINE
    Paul Cinciripini; Fiscal Year: 2000
    ..effects of nicotine administration and deprivation on changes in emotional processing among smokers carrying the DRD2 A1 and A2 alleles. Data from our laboratory suggest that smokers carrying the A1 allele vs...
  67. Dopamine and Iron in Restless Legs Syndrome
    Christopher Earley; Fiscal Year: 2006
    ..Prior PET and SPECT studies found small decreases in D2R binding potentials and one study have reported abnormal prolactin release...