DPP4

Summary

Gene Symbol: DPP4
Description: dipeptidyl peptidase 4
Alias: ADABP, ADCP2, CD26, DPPIV, TP103, dipeptidyl peptidase 4, ADCP-2, DPP IV, T-cell activation antigen CD26, adenosine deaminase complexing protein 2, dipeptidyl peptidase IV, dipeptidylpeptidase 4, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
Species: human

Top Publications

  1. ncbi Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence
    S Iwaki-Egawa
    Department of Clinical Biochemistry, Hokkaido College of Pharmacy, Otaru, Hokkaido, 047 0264, Japan
    J Biochem 124:428-33. 1998
  2. ncbi Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 105:779-83. 2003
  3. pmc Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
    Kathleen Aertgeerts
    Syrrx Inc, 10410 Science Center Drive, San Diego, CA 92121, USA
    Protein Sci 13:412-21. 2004
  4. pmc The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices
    Giulio Ghersi
    Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA
    Cancer Res 66:4652-61. 2006
  5. ncbi Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion
    R Lugari
    Department of Endocrinology and Metabolism, University of Parma, Ospedale Maggiore, Via Gramsci 14, 43100 Parma, Italy
    Horm Metab Res 36:111-5. 2004
  6. pmc Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Histopathology 55:432-40. 2009
  7. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
  8. ncbi Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes
    Y Torimoto
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 147:2514-7. 1991
  9. ncbi Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells
    Mario Gonzalez-Gronow
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:20993-8. 2004
  10. doi Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance
    Simone Post
    Department of Cardiology, Division Heart and Lung, UMCU, Utrecht, The Netherlands
    Cardiovasc Res 85:494-502. 2010

Research Grants

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  2. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
  3. A LYMPHOBLAST MODEL FOR DISEASES OF PURINE METABOLISM
    Michael Hershfield; Fiscal Year: 2006
  4. Nancy J Brown; Fiscal Year: 2014
  5. Jae W Lee; Fiscal Year: 2016
  6. EDWIN KERRY JACKSON; Fiscal Year: 2016
  7. Regulation of Stromal Derived Factor-1 Mediated Angiogenesis in Ischemic Brain
    Umadevi V Wesley; Fiscal Year: 2013
  8. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
  9. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
  10. Jonathan D Kaunitz; Fiscal Year: 2015

Patents

  1. Three-dimensional structure of dipeptidyl peptidase iv

Detail Information

Publications226 found, 100 shown here

  1. ncbi Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence
    S Iwaki-Egawa
    Department of Clinical Biochemistry, Hokkaido College of Pharmacy, Otaru, Hokkaido, 047 0264, Japan
    J Biochem 124:428-33. 1998
    b>Dipeptidyl peptidase IV (DPP IV) in normal human serum was purified 14,400-fold with a 25% yield to homogeneity...
  2. ncbi Increased adhesion potency of ovarian carcinoma cells to mesothelial cells by overexpression of dipeptidyl peptidase IV
    Fumitaka Kikkawa
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 105:779-83. 2003
    b>Dipeptidyl peptidase IV (DPPIV), cell surface peptidase, works as an adhesion molecule as well as an enzyme...
  3. pmc Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
    Kathleen Aertgeerts
    Syrrx Inc, 10410 Science Center Drive, San Diego, CA 92121, USA
    Protein Sci 13:412-21. 2004
    b>Dipeptidyl peptidase IV (DPPIV) is a member of the prolyl oligopeptidase family of serine proteases. DPPIV removes dipeptides from the N terminus of substrates, including many chemokines, neuropeptides, and peptide hormones...
  4. pmc The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices
    Giulio Ghersi
    Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA
    Cancer Res 66:4652-61. 2006
    b>Dipeptidyl peptidase IV (DPP4/CD26) and seprase/fibroblast activation protein alpha are homologous type II transmembrane, homodimeric glycoproteins that exhibit unique prolyl peptidase activities...
  5. ncbi Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion
    R Lugari
    Department of Endocrinology and Metabolism, University of Parma, Ospedale Maggiore, Via Gramsci 14, 43100 Parma, Italy
    Horm Metab Res 36:111-5. 2004
    ....
  6. pmc Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours
    Osamu Dohi
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Histopathology 55:432-40. 2009
    Fibroblast activation protein (FAP)/seprase and dipeptidylpeptidase-IV (DPP-IV)/CD26 are serine integral membrane proteases. They are involved in tissue remodelling, cancer invasion and metastases, mechanisms that are controversial...
  7. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
    ..This review focuses on some of the recently identified molecular details underlying the unusual transcellular transport pathway used by Tat, such as the role of the single Trp in Tat for its membrane insertion and translocation...
  8. ncbi Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes
    Y Torimoto
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 147:2514-7. 1991
    In the present report, we demonstrated that modulation of CD26 from T cell surface induced by antiCD26 (1F7) led to enhanced phosphorylation of CD3 zeta tyrosine residues and increased CD4 associated p56lck tyrosine kinase activity...
  9. ncbi Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells
    Mario Gonzalez-Gronow
    Department of Pathology, Box 3712, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:20993-8. 2004
    ..cells, but in some tissues, it is also associated with the cell surface multifunctional glycoprotein CD26/dipeptidyl peptidase IV. By modulating extracellular adenosine, this "ecto-ADA" may regulate adenosine receptor signaling ..
  10. doi Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance
    Simone Post
    Department of Cardiology, Division Heart and Lung, UMCU, Utrecht, The Netherlands
    Cardiovasc Res 85:494-502. 2010
    ..Stromal cell-derived factor-1alpha (SDF-1alpha) and the chemokine receptor CXCR4 are crucial for homing and negatively influenced by CD26. The aim of this study was to gain insight into the impaired homing of HHT1-MNCs.
  11. doi High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV
    C Marchetti
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Diabetologia 55:236-44. 2012
    ..b>Dipeptidyl peptidase IV (DPP-IV/CD26) is a protease whose activity is increased in diabetes and whose inhibition improves glucose ..
  12. doi Higher serum DPP-4 enzyme activity and decreased lymphocyte CD26 expression in type 1 diabetes
    Timea Varga
    2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    Pathol Oncol Res 17:925-30. 2011
    ..Our aim was to assess the serum DPP-4 activity and the lymphocyte membrane bound CD26 expression in patients with type 1 diabetes and healthy controls...
  13. ncbi Heparan sulfate/heparin oligosaccharides protect stromal cell-derived factor-1 (SDF-1)/CXCL12 against proteolysis induced by CD26/dipeptidyl peptidase IV
    Rabia Sadir
    Institut de Biologie Structurale, CNRS Commissariat à l Enérgie Atomique Université Joseph Fourier, Unité Mixte de Recherche 5075, 41 Rue Horowitz, 38027 Grenoble Cedex 01, France
    J Biol Chem 279:43854-60. 2004
    ..In particular, CD26/dipeptidyl peptidase IV (DPP IV), a serine protease that co-distributes with CXCR4 at the cell surface, mediates the selective ..
  14. ncbi Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness
    M Subramanyam
    Department of Pathology, Tufts University School of Medicine, Boston, MA 02111
    J Immunol 150:2544-53. 1993
    ..binds to and partially inhibits the enzymatic activity of dipeptidyl aminopeptidase type IV (DP IV), also known as CD26, which is expressed on a variety of mammalian tissue, including T lymphocytes...
  15. ncbi 3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis
    Kai Ludwig
    Forschungszentrum für Elektronenmikroskopie, Freie Universitat Berlin, Fabeckstr 36a, D14195 Berlin Dahlem, Germany
    Biochem Biophys Res Commun 313:223-9. 2004
    The specific binding of adenosine deaminase to the multifunctional membrane glycoprotein dipeptidyl peptidase IV is thought to be immunologically relevant for certain regulatory and co-stimulatory processes...
  16. ncbi Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation
    D Darmoul
    Unité de Recherches sur la Différenciation Cellulaire Intestinale Institut National de la Santé et de la Recherche Médicale U178, Villejuif, France
    J Biol Chem 267:4824-33. 1992
    A cDNA (DPCR1) specific for human intestinal dipeptidyl peptidase IV (DPP IV) has been isolated. This 1...
  17. ncbi Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule
    M Martin
    Department of Biochemistry and Molecular Biology, University of Barcelona, Catalonia, Spain
    J Immunol 155:4630-43. 1995
    The expression of surface adenosine deaminase (ADA) and CD26 in activated human T cells was studied by flow cytometry...
  18. pmc Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity
    W G Gutheil
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111
    Proc Natl Acad Sci U S A 91:6594-8. 1994
    ..Tat binds with high affinity to the T-cell activation molecule dipeptidyl aminopeptidase IV (DP IV), also known as CD26. This molecule occurs on the surface of CD4+ cells responsible for the recall antigen response and appears to play ..
  19. ncbi Regulation of fibroblast migration on collagenous matrix by a cell surface peptidase complex
    Giulio Ghersi
    Department of Medicine Medical Oncology, State University of New York, Stony Brook, New York 11794 8154, USA
    J Biol Chem 277:29231-41. 2002
    ..formation of a novel protease complex, consisting of the membrane-bound prolyl peptidases seprase and dipeptidyl peptidase IV (DPPIV), at invadopodia of migratory fibroblasts is a prerequisite for cell invasion and migration on a ..
  20. pmc CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1
    Kei Ohnuma
    Department of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 101:14186-91. 2004
    CD26 is a T cell costimulatory molecule with dipeptidyl peptidase IV activity in its extracellular region...
  21. pmc Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Blood 108:1602-10. 2006
    ..Further studies in human endothelia revealed that ADA-complexing protein CD26 is coordinately induced by hypoxia, effectively localizing ADA activity at the endothelial cell surface...
  22. ncbi Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1
    Kei Ohnuma
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:10117-31. 2007
    b>CD26 is a widely distributed 110-kDa cell surface glycoprotein with an important role in T-cell costimulation...
  23. doi Comprehensive genetic analysis of the dipeptidyl peptidase-4 gene and cardiovascular disease risk factors in obese individuals
    Luigi Bouchard
    Lipid Research Center, Laval University, 2705 Laurier Blvd TR93, Quebec City, QC, Canada G1V 4G2
    Acta Diabetol 46:13-21. 2009
    ..Recently, we have shown that the dipeptidylpeptidase-4 (DPP4) gene, which is responsible for incretin inactivation, was overexpressed in omental adipose tissue of obese men ..
  24. pmc Expression and activity profiles of DPP IV/CD26 and NEP/CD10 glycoproteins in the human renal cancer are tumor-type dependent
    Adolfo Varona
    Department of Physiology, Faculty of Medicine and Dentistry, University of Basque Country, Barrio Sarriena s n, 48940 Leioa, Spain
    BMC Cancer 10:193. 2010
    ..b>DPP IV and NEP are ubiquitous glycopeptidases closely linked to tumor pathogenesis and development, and they are used as ..
  25. doi CD26 overexpression is associated with prolonged survival and enhanced chemosensitivity in malignant pleural mesothelioma
    Keisuke Aoe
    Department of Medical Oncology and Clinical Research, National Hospital Organization Yamaguchi Ube Medical Center, Ube, Yamaguchi, Japan
    Clin Cancer Res 18:1447-56. 2012
    ..Malignant pleural mesothelioma (MPM) is an aggressive and therapy-resistant neoplasm arising from the pleural mesothelial cells, without established indicators to predict responsiveness to chemotherapy...
  26. doi Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and -independent actions
    Toshimasa Shigeta
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circulation 126:1838-51. 2012
    The inhibition of dipeptidyl peptidase-4 (DPP4) protects the heart from acute myocardial ischemia. However, the role of DPP4 in chronic heart failure independent of coronary artery disease remains unclear.
  27. ncbi Cloning and functional expression of the T cell activation antigen CD26
    T Tanaka
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 149:481-6. 1992
    ..The predicted amino acid sequence of the Ag was 85% homologous to that of the dipeptidyl peptidase IV enzyme isolated from rat liver...
  28. ncbi Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface
    Y Misumi
    Department of Biochemistry, Fukuoka University School of Medicine, Japan
    Biochim Biophys Acta 1131:333-6. 1992
    The cDNA coding for the human dipeptidyl peptidase IV (DPPIV) has been isolated and sequenced...
  29. pmc Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter
    S K Bohm
    Gastrointestinal Research Laboratory 151M2, Department of Veterans Affairs Medical Center, San Francisco, CA, USA
    Biochem J 311:835-43. 1995
    The dipeptidyl peptidase IV gene encodes a plasma-membrane exopeptidase that is highly expressed in small intestine, lung and kidney...
  30. ncbi T cell activation antigen, CD26, as a cofactor for entry of HIV in CD4+ cells
    C Callebaut
    Unité de Virologie et Immunologie Cellulaire, UA CNRS, Institut Pasteur, Paris, France
    Science 262:2045-50. 1993
    ..The cofactor was shown to be dipeptidyl peptidase IV (DPP IV), also known as CD26...
  31. pmc Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
    M J Scanlan
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Proc Natl Acad Sci U S A 91:5657-61. 1994
    ..48% amino acid sequence identity to the T-cell activation antigen CD26, a membrane-bound protein with dipeptidyl peptidase IV (DPPIV) activity; however, unlike FAP alpha, CD26 is widely expressed in normal tissues...
  32. pmc A marker for neoplastic progression of human melanocytes is a cell surface ectopeptidase
    M E Morrison
    Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Exp Med 177:1135-43. 1993
    ..Five tryptic peptides from purified human ADAbp revealed 100% homology to a serine protease, human dipeptidyl peptidase IV (DPP IV), also known as CD26...
  33. ncbi Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    R Mentlein
    Anatomisches Institut, Universitat Kiel, Germany
    Eur J Biochem 214:829-35. 1993
    ..The relevance of this finding for their inactivation and their determination by immunoassays is discussed...
  34. ncbi Specific binding of adenosine deaminase but not HIV-1 transactivator protein Tat to human CD26
    J Blanco
    Unité de Virologie et d Immunologie Cellulaire, UA CNRS 1157, Institut Pasteur, Paris Cedex, France
    Exp Cell Res 225:102-11. 1996
    ..ADA) and the HIV-1 transactivator protein Tat have been reported to bind to human CD26, also known as dipeptidyl peptidase IV (DPP IV). In order to demonstrate the specificity of such binding under native conditions of CD26, i.e...
  35. ncbi The N-terminal X-X-Pro sequence of the HIV-1 Tat protein is important for the inhibition of dipeptidyl peptidase IV (DP IV/CD26) and the suppression of mitogen-induced proliferation of human T cells
    S Wrenger
    Center for Internal Medicine, Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, Germany
    FEBS Lett 383:145-9. 1996
    ..Moreover, Tat was found to interact with dipeptidyl peptidase IV (DP IV), which is identical to the T cell activation marker CD26...
  36. ncbi Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Biol Chem 273:7222-7. 1998
    ..The serine protease CD26/dipeptidyl-peptidase IV (CD26/DPP IV) could induce this observed NH2-terminal truncation of GCP-2 and RANTES but not that of the monocyte chemotactic ..
  37. ncbi The significance of hypersialylation of dipeptidyl peptidase IV (CD26) in the inhibition of its activity by Tat and other cationic peptides. CD26: a subverted adhesion molecule for HIV peptide binding
    R E Smith
    Protek, Inc, Dublin, California 94568, USA
    AIDS Res Hum Retroviruses 14:851-68. 1998
    The functionality of DPP-IV, purified from human placenta and isolated from CD4+/CD26+ T cells of noninfected and HIV-1-infected individuals, was investigated as to its ability to bind certain specific peptides...
  38. ncbi Processing by CD26/dipeptidyl-peptidase IV reduces the chemotactic and anti-HIV-1 activity of stromal-cell-derived factor-1alpha
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Belgium
    FEBS Lett 432:73-6. 1998
    ..SDF-1alpha was NH2-terminally cleaved to SDF-1alpha(3-68) by dipeptidyl-peptidase IV (CD26/DPP IV), which is present in blood in soluble and membrane-bound form...
  39. ncbi Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts
    J E Park
    Department of Oncology Research, Boehringer Ingelheim Pharma KG, Birkendorferstrasse 65, 88397 Biberach, Germany
    J Biol Chem 274:36505-12. 1999
    ..This study demonstrates that FAP is present as an active cell surface-bound collagenase in epithelial tumor stroma and opens up investigation into physiological substrates of its novel, tumor-associated dipeptidyl peptidase activity...
  40. pmc Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
    H Ikushima
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:8439-44. 2000
    CD26 is a T cell activation antigen known to bind adenosine deaminase and have dipeptidyl peptidase IV activity. Cross-linking of CD26 and CD3 with immobilized mAbs can deliver a costimulatory signal that contributes to T cell activation...
  41. ncbi Comodulation of CXCR4 and CD26 in human lymphocytes
    C Herrera
    Department of Biochemistry and Molecular Biology, Faculty of Chemistry, University of Barcelona, Marti i Franques 1, 08028 Barcelona, Catalonia, Spain
    J Biol Chem 276:19532-9. 2001
    We provide convergent and multiple evidence for a CD26/CXCR4 interaction. Thus, CD26 codistributes with CXCR4, and both coimmunoprecipitate from membranes of T (CD4(+)) and B (CD4(-)) cell lines...
  42. ncbi Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
    A M Lambeir
    Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1 S6, B 2610 Antwerp, Belgium
    J Biol Chem 276:29839-45. 2001
    ..The localization of CD26/dipeptidyl peptidase IV on cell surfaces and in biological fluids, its primary specificity, and the type of naturally occurring ..
  43. ncbi Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties
    P Proost
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, Leuven, Belgium
    Blood 98:3554-61. 2001
    ..Recently, the highly specific membrane-bound protease and lymphocyte surface marker CD26/dipeptidyl peptidase IV (DPP IV) was found to be responsible for posttranslational processing of chemokines...
  44. ncbi Soluble CD26/dipeptidyl peptidase IV induces T cell proliferation through CD86 up-regulation on APCs
    K Ohnuma
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 167:6745-55. 2001
    CD26 is a T cell costimulatory molecule with dipeptidyl peptidase IV enzyme activity in its extracellular region...
  45. ncbi Dipeptidyl peptidase IV activity in patients with ACE-inhibitor-associated angioedema
    Jean Lefebvre
    Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 6602, USA
    Hypertension 39:460-4. 2002
    ..defect in a non-ACE, non-kininase I pathway of bradykinin degradation, such as the aminopeptidase P (APP)/dipeptidyl peptidase IV (DPPIV) pathway...
  46. ncbi Involvement of dipeptidyl peptidase IV in extravillous trophoblast invasion and differentiation
    Yukiyasu Sato
    Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Endocrinol Metab 87:4287-96. 2002
    Previously, we reported that dipeptidyl peptidase IV (DPPIV), a membrane-bound peptidase, was expressed on human placental cytotrophoblasts. In the present study, we focused on DPPIV expression on extravillous trophoblasts (EVTs)...
  47. ncbi Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells
    Kent W Christopherson
    Department of Microbiology Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5254, USA
    J Immunol 169:7000-8. 2002
    CD26/dipeptidylpeptidase IV (DPPIV) is a membrane-bound extracellular peptidase that cleaves dipeptides from the N terminus of polypeptide chains...
  48. ncbi Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
    Hanne B Rasmussen
    Protein Chemistry, Research and Development, Novo Nordisk A S, Novo Alle, DK 2880 Bagsvaerd, Denmark
    Nat Struct Biol 10:19-25. 2003
    b>Dipeptidyl peptidase IV (DPP-IV/CD26) is a multifunctional type II transmembrane serine peptidase...
  49. ncbi Similar increased serum dipeptidyl peptidase IV activity in chronic hepatitis C and other viral infections
    T Andrieu
    Laboratoire de Virologie, CERVI, UPRES EA 2387, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    J Clin Virol 27:59-68. 2003
    b>Dipeptidyl peptidase IV is a transmembrane enzyme widely expressed in many cell types, but also present as a soluble form in biological fluids. Its abnormal activity is sometimes associated with liver disease related pathologies.
  50. ncbi CD26/dipeptidyl peptidase IV and its role in cancer
    B Pro
    Department of Lymphoma Myeloma, Unit 429, M D Anderson Cancer Center, Houston, TX 77303, USA
    Histol Histopathol 19:1345-51. 2004
    CD26/Dipeptidyl Peptidase IV (DPPIV) is a 110-kDa glycoprotein that is expressed on numerous cell types and has multiple biological functions...
  51. ncbi Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
    Mark D Gorrell
    A W Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and Discipline of Medicine, The University of Sydney, Sydney, New South Wales, Australia
    Clin Sci (Lond) 108:277-92. 2005
    ..The DPL (DP-like) glycoproteins that lack peptidase activity, DPL1 and DPL2, are brain-expressed potassium channel modulators. Thus the six members of the DPIV gene family exhibit diverse biological roles...
  52. pmc Circulating CD26 is negatively associated with inflammation in human and experimental arthritis
    Nathalie Busso
    Laboratoire de Rhumatologie, Centre Hospitalier Universitaire Vaudois, Nestlé 05 5029, 1011 Lausanne, Switzerland
    Am J Pathol 166:433-42. 2005
    b>Dipeptidyl peptidase IV (DPPIV, CD26), a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and nonimmune ..
  53. ncbi Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26)
    Wilhelm Andreas Weihofen
    Institut für Chemie Kristallographie, Freie Universitat Berlin, Takustrasse 6, D 14195 Berlin, Germany
    J Biol Chem 280:14911-7. 2005
    CD26 or dipeptidyl-peptidase IV (DPPIV) is engaged in immune functions by co-stimulatory effects on activation and proliferation of T lymphocytes, binding to adenosine deaminase, and regulation of various chemokines and cytokines...
  54. ncbi Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitus
    E Mannucci
    Diabetology, Geriatric Unit, Department of Critical Care, University of Florence, Florence, Italy
    Diabetologia 48:1168-72. 2005
    Chronic hyperglycaemia increases dipeptidyl peptidase IV (DPP-IV) activity in endothelial cells in vitro...
  55. ncbi Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells
    Mario Gonzalez-Gronow
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:27173-8. 2005
    Binding of plasminogen type II (Pg 2) to dipeptidyl peptidase IV (DPP IV) on the surface of the highly invasive 1-LN human prostate tumor cell line induces an intracellular Ca2+ ([Ca2+]i) signaling cascade accompanied by a rise in ..
  56. ncbi The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26
    Jamshid Davoodi
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Proteomics 7:2300-10. 2007
    ..cell lines for proteins that interact with GPC3, resulting in the isolation of a 115 kDa protein, identified as CD26. The interaction occurred with both the glycosylated and unglycosylated forms of GPC3 and led to the inhibition of ..
  57. ncbi Decreased dipeptidyl peptidase-IV activity and glucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects
    Aine M McKillop
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Diabetes Res Clin Pract 79:79-85. 2008
    ..These data indicate decreased DPP-IV activity and GLP-1 degradation in type 2 diabetes. DPP-IV enzyme activity appears to be depressed in response to poor glycaemic control...
  58. ncbi Dipeptidyl peptidase IV (DDP IV) in NASH patients
    Yasemin H Balaban
    Department of Internal Medicine, Division of Gastroenterology, Abant Izzet Baysal University, Bolu Turkey
    Ann Hepatol 6:242-50. 2007
    ..The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions...
  59. doi Stromal cell-derived factors 1alpha and 1beta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8
    Katerina Ajami
    Centenary Institute, Faculty of Medicine, University of Sydney, Newtown, Sydney, NSW, Australia
    FEBS Lett 582:819-25. 2008
    ..This has implications for DP8 substrate specificity. Chemokine cleavage and inactivation may occur in vivo upon cell lysis and release of DP8 or in the inactivation of internalized chemokine/receptor complexes...
  60. doi CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12
    Yan Xi Sun
    Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Room 3307, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
    Clin Exp Metastasis 25:765-76. 2008
    ..Fractionation and inhibitor studies suggested that the activity was CD26/dipeptidyl peptidase IV (DPPIV) and possibly other cysteine/serine proteases...
  61. ncbi Dipeptidyl peptidase IV expression in cancer and stromal cells of human esophageal squamous cell carcinomas, adenocarcinomas and squamous cell carcinoma cell lines
    Mariusz Adam Goscinski
    Department of Surgery, Rikshospitalet Radiumhospitalet Medical Centre, Medical Faculty, University of Oslo, Montebello, Oslo, Norway
    APMIS 116:823-31. 2008
    b>Dipeptidyl peptidase IV (DPPIV) is a transmembrane serine protease which is involved in the process of tumor invasion and development of metastases in human cancers...
  62. doi Significant lower VVH7-like immunoreactivity serum level in diabetic patients: evidence for independence from metabolic control and three key enzymes in hemorphin metabolism, cathepsin D, ACE and DPP-IV
    D Feron
    UMR 6250 CNRS ULR, LIENSS Littoral, Environnement, sociétés, Equipe MAB Pôle Sciences et Technologie, UFR Sciences et Technologie, Universite de La Rochelle, France
    Peptides 30:256-61. 2009
    ..Three enzymatic tests were also applied to determine serum cathepsin D (CD), dipeptidyl peptidase IV (DPP-IV) and angiotensin-converting enzyme (ACE) activities...
  63. doi CD26 expression in mature B-cell neoplasia: its possible role as a new prognostic marker in B-CLL
    Lilla Cro
    Fondazione Ospedale Maggiore Policlinico MaRe, IRCCS, Centro di Genetica Molecolare, UO Ematologia 1 CTMO, Laboratorio diagnostica onco ematologica, 20122Milan, Italy
    Hematol Oncol 27:140-7. 2009
    CD26 (dipeptidyl peptidase IV, DPP IV) is widely expressed by T and natural killer (NK) cells, epithelial and endothelial cells of different tissues, and it is strongly upregulated in activated B-cells; moreover it plays a regulatory ..
  64. doi Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
    Marc Vanderheyden
    Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Aalst, Belgium
    Clin Chem Lab Med 47:248-52. 2009
    ..that this BNP(1-32) might be an ideal substrate for the endogenous aminopeptidase, dipeptidyl-peptidase IV (DPP IV)...
  65. pmc CD26 expression on T cell lines increases SDF-1-alpha-mediated invasion
    P A Havre
    Division of Hematology Oncology, University of Florida, Gainesville, FL 32610, USA
    Br J Cancer 101:983-91. 2009
    b>CD26 is a multifunctional membrane-bound glycoprotein that regulates tumour growth in addition to its other activities...
  66. doi Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men
    Richard D Carr
    Department of Clinical Sciences Lund, B11 BMC, SE 2221 84 Lund, Sweden
    J Clin Endocrinol Metab 95:872-8. 2010
    ..The impact of this increase on incretin hormone secretion and metabolism is not known...
  67. pmc Soluble CD26 levels and its association to epidemiologic parameters in a sample population
    Loretta De Chiara
    Universidad de Vigo, Facultad de Biologia, Departamento de Bioquimica, Genética e Inmunología, As Lagoas Marcosende s n, 36310 Vigo, Spain
    Dis Markers 27:311-6. 2009
    Previous studies have suggested the use of soluble CD26 (sCD26) as a tumour marker for the detection of colorectal cancer (CRC) and advanced adenomas...
  68. doi A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer
    Roberta Pang
    Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR
    Cell Stem Cell 6:603-15. 2010
    ..However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26(+) cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver ..
  69. pmc Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas
    Loretta De Chiara
    Universidad de Vigo, Facultad de Biologia, Departamento de Bioquimica, Genética e Inmunología, As Lagoas Marcosende s n, 36310 Vigo, Spain
    BMC Cancer 10:333. 2010
    Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis...
  70. pmc Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease: a novel liver disease biomarker
    Gabor Firneisz
    Department of Medicine, Semmelweis University, Budapest, Hungary
    PLoS ONE 5:e12226. 2010
    ....
  71. doi Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines
    Wataru Takasawa
    Division of Clinical Immunology, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 401:7-12. 2010
    ..Recently, CD26/dipeptidyl peptidase 4 (DPP-4) inhibition has been used as a novel oral therapeutic approach for patients with type 2 diabetes...
  72. doi DPP4 gene DNA methylation in the omentum is associated with its gene expression and plasma lipid profile in severe obesity
    Valérie Turcot
    Nutraceuticals and Functional Foods Institute, Quebec, Quebec, Canada
    Obesity (Silver Spring) 19:388-95. 2011
    Severely obese subjects with the metabolic syndrome (MS) have higher dipeptidyl peptidase-4 (DPP4) expression in their visceral adipose tissue (VAT) compared to obese individuals without MS...
  73. pmc Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome
    Daniela Lamers
    Paul Langerhans Group, German Diabetes Center, Duesseldorf, Germany
    Diabetes 60:1917-25. 2011
    Comprehensive proteomic profiling of the human adipocyte secretome identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine...
  74. doi Overexpression of CD26/DPPIV in mesothelioma tissue and mesothelioma cell lines
    Vishwa Jeet Amatya
    Department of Pathology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    Oncol Rep 26:1369-75. 2011
    ..CD26, a 110-kDa transmembrane glycoprotein with known dipeptidyl peptidase IV activity, plays a role in tumor development and its expression was reported in various human ..
  75. doi Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabetes controlled inadequately by metformin and/or sulfonylurea
    Yoshimasa Aso
    Department of Internal Medicine, Koshigaya Hospital, Dokkyo Medical University, Saitama, Japan
    Transl Res 159:25-31. 2012
    b>Dipeptidyl peptidase 4 (DPP-4) inhibitors is a new class of antihyperglycemic agents that is now available for the treatment of type 2 diabetes...
  76. doi Characterization of cancer stem cell properties of CD24 and CD26-positive human malignant mesothelioma cells
    Hiroto Yamazaki
    Division of Clinical Immunology, Institute of Medical Science, University of Tokyo, Japan
    Biochem Biophys Res Commun 419:529-36. 2012
    ..Among these markers, we focused on two: CD24, the common CSC marker, and CD26, the additional CSC marker. We further analyzed the CSC properties of CD24 and CD26-positve MM cells...
  77. pmc Plasma seprase and DPP4 levels as markers of disease and prognosis in cancer
    Mazyar Javidroozi
    Department of Medicine, Stony Brook University, NY, USA
    Dis Markers 32:309-20. 2012
    ..We studied whether plasma levels of seprase and homologous protease, DPP4 in cancer might serve as tumor biomarkers...
  78. doi Serum levels of advanced glycation end products (AGEs) are independently correlated with circulating levels of dipeptidyl peptidase-4 (DPP-4) in humans
    Nobuhiro Tahara
    Department of Medicine, Division of Cardio Vascular Medicine, Kurume University School of Medicine, Kurume, Japan
    Clin Biochem 46:300-3. 2013
    ..Further, we investigated the effects of AGEs on DPP-4 expression in, and soluble DPP-4 release from human cultured proximal tubular epithelial cells...
  79. pmc Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance
    Satish Khurana
    Interdepartmental Stem Cell Institute, KU Leuven, Leuven, Belgium
    Blood 121:2587-95. 2013
    ..b>CD26 is a widely expressed membrane-bound ectopeptidase that cleaves CXCL12 thereby depleting its chemokine activity...
  80. doi Evaluating second-line treatment options for type 2 diabetes: focus on secondary effects of GLP-1 agonists and DPP-4 inhibitors
    Cassie L Boland
    School of Pharmacy, Wingate University, Wingate, NC, USA
    Ann Pharmacother 47:490-505. 2013
    ....
  81. pmc Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription
    Kohji Yamada
    Department of Pathology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    PLoS ONE 8:e62304. 2013
    CD26 is a type II glycoprotein known as dipeptidyl peptidase IV and has been identified as one of the cell surface markers associated with various types of cancers and a subset of cancer stem cells...
  82. pmc Prognostic significance of CD26 in patients with colorectal cancer
    Colin Siu Chi Lam
    Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 9:e98582. 2014
    CD26, dipeptidyl peptidase IV, was discovered firstly as a membrane-associated peptidase on the surface of leukocyte...
  83. pmc Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer
    Arpi Nazarian
    From the Protein Center, Memorial Sloan Kettering Cancer Center, New York, New York 10065
    Mol Cell Proteomics 13:3082-96. 2014
    ..We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors...
  84. ncbi The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression
    J Blanco
    Unité de Virologie et dImmunologie Cellulaire, ERS 572 CNRS, Institut Pasteur, 28 rue Dr Roux, 75724 Paris Cedex 15, France
    FEBS Lett 477:123-8. 2000
    ..envelope glycoprotein gp120 inhibits adenosine deaminase (ADA) binding to its cell surface receptor in lymphocytes, CD26, by a mechanism that does not require the gp120-CD4 interaction...
  85. ncbi Direct association of adenosine deaminase with a T cell activation antigen, CD26
    J Kameoka
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA
    Science 261:466-9. 1993
    CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein...
  86. ncbi The N-terminal structure of HIV-1 Tat is required for suppression of CD26-dependent T cell growth
    S Wrenger
    Center for Internal Medicine, Institute of Experimental Internal Medicine, Otto von Guericke University Magdeburg, D 39120 Magdeburg, Germany
    J Biol Chem 272:30283-8. 1997
    ..which has been shown to play a key role in the regulation of growth of lymphocytes and to inhibit its dipeptidyl peptidase IV (DP IV) activity...
  87. doi Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure
    Leonardo dos Santos
    Heart Institute
    Circ Heart Fail 6:1029-38. 2013
    The present study addresses the hypothesis that the activity of dipeptidyl peptidase IV (DPPIV), an enzyme that inactivates peptides that possess cardioprotective actions, correlates with adverse outcomes in heart failure (HF)...
  88. ncbi Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi
    Alexander Roesch
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    Mod Pathol 19:1378-85. 2006
    ..MIB-1/Ki-67 was analyzed as an example for a common proliferation marker. Dipeptidyl peptidase IV/CD26 was analyzed as a marker affecting both proliferation and invasion of malignant melanocytic tumors...
  89. ncbi CD26 and DPP IV expression in T acute lymphoblastic leukemia cells: immunocytochemistry and enzyme cytochemistry
    M Klobusicka
    Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovak Republic
    Gen Physiol Biophys 18:34-7. 1999
    Recent studies have revealed the dipeptidyl peptidase IV (DPP IV) enzymatic activity of CD26 antigen. In this paper, the possible identity of DPP IV and CD26 expression in phenotypically defined T-ALL has been examined...
  90. doi CD26/DPPIV cell membrane expression and DPPIV activity in plasma of patients with acute leukemia
    Camilla F C G de Andrade
    Laboratório de Genética Aplicada, Serviço de Hematologia do Hospital do Câncer I, Instituto Nacional de Cancer, Praça da Cruz Vermelha 23CEP 20230 130, Rio de Janeiro, RJ, Brazil
    J Enzyme Inhib Med Chem 24:708-14. 2009
    ..The regulation of biological activities of cytokines by DPP IV activity has a potential role in the homeostatic regulation of hematopoiesis...
  91. ncbi Dipeptidyl Peptidase-4 (CD26): Knowing the Function before Inhibiting the Enzyme
    E Matteucci
    Department of Internal Medicine, University of Pisa, Italy
    Curr Med Chem 16:2943-51. 2009
    Dipeptidyl peptidase-4 (DPP4) or adenosine deaminase complexing protein 2 (ADCP 2) or T-cell activation antigen CD26 (EC 3.4.14.5...
  92. ncbi Binding of adenosine deaminase to the lymphocyte surface via CD26
    I De Meester
    Department of Clinical Biochemistry, University of Antwerp, Wilrijk, Belgium
    Eur J Immunol 24:566-70. 1994
    The relationship between CD26/dipeptidyl peptidase IV, an ectopeptidase involved in T cell activation, and the binding protein for adenosine deaminase (ADAbp) was studied...
  93. pmc The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency
    E Richard
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 192:1223-36. 2000
    Human, but not murine, adenosine deaminase (ADA) forms a complex with the cell membrane protein CD26/dipeptidyl peptidase IV. CD26-bound ADA has been postulated to regulate extracellular adenosine levels and to modulate the costimulatory ..
  94. pmc Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation
    José M Martinez-Navio
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Immunology 128:393-404. 2009
    The cell surface association between CD26 and adenosine deaminase (ADA) has a costimulatory function during T-cell activation...
  95. ncbi [Identification and localization of exopeptidase activities bound to membranes of Acinetobacter calcoaceticus]
    G Jahreis
    , Bereich Medizin, , Saale
    Biomed Biochim Acta 48:517-28. 1989
    ..Only gamma-glutamyl arylamidase is located with its main activity in the cytoplasmic membrane (band M). Only small exopeptidase activities could be found in the outer membrane (band H)...
  96. doi Dipeptidyl peptidase IV in the hypothalamus and hippocampus of monosodium glutamate obese and food-deprived rats
    Rafaela Fadoni Alponti
    Laboratory of Pharmacology, Instituto Butantan, Av Vital Brasil, 1500, 05503 900 Sao Paulo, SP, Brazil
    Metabolism 60:234-42. 2011
    ..This study investigates the relationship among dipeptidyl peptidase IV (DPPIV) hydrolyzing activity, CD26 protein, fasting, and MSG model of obesity in 2 areas of the central ..
  97. doi Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α
    Fiona M Keane
    Centenary Institute, Sydney Medical School, University of Sydney, NSW, Australia
    FEBS J 278:1316-32. 2011
    ..FAP) is a cell surface-expressed and soluble enzyme of the prolyl oligopeptidase family, which includes dipeptidyl peptidase 4 (DPP4)...
  98. doi Characterization of glucagon-like peptide 2 pathway member expression in bovine gastrointestinal tract
    E E Connor
    Beltsville Agricultural Research Center, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 93:5167-78. 2010
    ..cleavage by prohormone convertase; (2) prohormone convertase (PCSK1); (3) GLP-2 receptor (GLP2R); and (4) dipeptidyl peptidase IV (DPP4), the enzyme that inactivates GLP-2...
  99. ncbi Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism
    A Vojdani
    Lab Comparative Immunology, Dept Neurobiology, UCLA Medical Center, Los Angeles, CA, USA
    Int J Immunopathol Pharmacol 16:189-99. 2003
    ..gliadin and casein) and ethyl mercury (xenobiotic) bind to different lymphocyte receptors and tissue enzyme (DPP IV or CD26)...
  100. doi Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries
    Veerle Matheeussen
    Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerp, Belgium
    Biol Chem 392:189-98. 2011
    b>Dipeptidyl peptidase IV (DPPIV)/CD26 is by far the most extensively studied member of the prolyl oligopeptidase family of serine proteases...
  101. pmc Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1alpha (SDF-1alpha) and SDF-1beta are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
    T Shioda
    Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Proc Natl Acad Sci U S A 95:6331-6. 1998
    CD26 is a leukocyte-activation antigen that is expressed on T lymphocytes and macrophages and possesses dipeptidyl peptidase IV (DPPIV) activity, whose natural substrates have not been identified yet...

Research Grants49

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..It is cleaved by dipeptidyl peptidase IV (DPPIV) and thus it biological half-life is short...
  3. A LYMPHOBLAST MODEL FOR DISEASES OF PURINE METABOLISM
    Michael Hershfield; Fiscal Year: 2006
    ..We have defined the binding site of ADA for the cell membrane protein CD26, and provided evidence that ADA/CD26 interaction is not essential for immune function in humans...
  4. Nancy J Brown; Fiscal Year: 2014
    ..group has identified one biochemical mechanism underlying ACE inhibitor associated- angioedema, that of dipeptidyl peptidase IV (DPPIV) deficiency...
  5. Jae W Lee; Fiscal Year: 2016
    ..through the regulation of a gene encoding a key modifier of Tgr5 signaling, 'dipeptidyl peptidase-4'(Dpp4), which inactivates GLP-1...
  6. EDWIN KERRY JACKSON; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Dipeptidyl peptidase IV (DPPIV) inhibitors are a new class of drugs for treatment of type 2 diabetes. Because drugs in this class [e.g...
  7. Regulation of Stromal Derived Factor-1 Mediated Angiogenesis in Ischemic Brain
    Umadevi V Wesley; Fiscal Year: 2013
    ..Thus preventing SDF1 inactivation is of clinical importance. Although the protease dipeptidyl peptidase 4 (DPPIV) is shown to cleave SDF1, its role in ischemic stroke is unknown...
  8. Stress and Platelet NPY in Vascular Remodeling
    John W Osborn; Fiscal Year: 2012
    ..This is mediated by vascular and monocytic Y1R (Aim 1/3A), and antagonized by endothelial and macrophage-derived DPPIV/cd26 (Aim 1/3B), which inactivates NPY- Y1R-mediated and monocytic chemoattractant activities of RANTES and SDF-1 (..
  9. Cytokine Induced CD26 Modulation of Adult Hematopoietic Stem Cell Trafficking
    Kent Christopherson; Fiscal Year: 2009
    ..Towards this goal, we recently demonstrated that inhibition or loss of CD26 (DPPIV/dipeptidylpeptidase IV) significantly improved HSCT efficiency...
  10. Jonathan D Kaunitz; Fiscal Year: 2015
    ..Furthermore, GLP-2 is metabolized principally by the enzyme dipeptidyl peptidase IV (DPPIV), a diabetes drug...
  11. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
    ..Jeffrey Spees: Adult Bone Marrow Stem Cells For CMS Repair, and 4) Dr. Umadevi Wesley: Role of Dipeptidyl Peptidase IV (DPPIV) in Peripheral Neurogenesis and Neuroblastomas...
  12. Julia Pinkhasov; Fiscal Year: 2014
    ..recently made a novel observation that in addition to TCR signal, a cohort of molecules, such as CD5, CD6, GITR and CD26 alter the TCR signal potential and contribute to establishing a diverse T cell repertoire...
  13. Sherif S Farag; Fiscal Year: 2016
    ..studies on CD26/Dipeptidylpeptidase (DPP) IV activities reported herein, we believe that inhibition of CD26/DPPIV will significantly enhance engraftment capability of limiting numbers of human CB cells, and accelerate time to ..
  14. Role of Oral vs Injectable Glucagon Suppressors
    Rubina A Heptulla; Fiscal Year: 2013
    ..Sitagliptin acts by inhibiting dipeptidyl peptidase 4 (DPP4) the enzyme that metabolizes GLP-1 and increasing endogenous GLP-1...
  15. INTESTINAL PEPTIDE HYDROLASES AND PEPTIDE TRANSPORT
    Young Kim; Fiscal Year: 2000
    ..The gene promoter of one of these enzymes, DPPIV, will be characterized and mapped in detail. The 5'-flanking sequence of DPPIV possesses promoter activity...
  16. RAT MODEL OF TRANSPLANTABLE HEPATOCELLULAR CARCINOMA
    Douglas Hixson; Fiscal Year: 1992
    ..of Fisher 344 rats (called the German Fisher 344 rat) which lacks an enzymatically active form of dipeptidyl peptidase IV (DDPIV)...
  17. MOLECULAR DETERMINANTS OF MULTICELLULAR ORGANIZATION
    Douglas Hixson; Fiscal Year: 2003
    ..interactions of hepatocytes or THC transduced with double expression vectors carrying cDNAs for C-CAM and dipeptidyl peptidase IV (DPPIV), a cell surface exoprotease, will be characterized following transplantation into the livers of ..
  18. Murine Model for Hepatitis Antiviral/Anticancer Testing
    Margherita Melegari; Fiscal Year: 2004
    ..Recently, a dipeptidyl peptidase IV knockout allele (DPPIV-/-) has been added to the genotype of the recipient mice and this allows direct ..
  19. Strategies for prenatal stem cell transplantation
    Alan W Flake; Fiscal Year: 2010
    ..improve homing and engraftment of donor cells after in utero transplantation by blockade of the dipeptidylpeptidase CD26. The studies in this proposal are designed to develop and optimize novel approaches to IUHCT that will be safely ..
  20. REGULATION OF TISSUE REPAIR
    Wen Tien Chen; Fiscal Year: 2002
    ..A group of serine integral membrane proteases (seprase and dipeptidyl peptidase IV [DPPIV] are implicated in cell surface collagen proteolysis that occurs at the leading edge invadopodia ..
  21. IMMUNOREGULATORY CIRCUITS IN MAN
    Chikao Morimoto; Fiscal Year: 2002
    ..Moreover, the role of Cas-L in T-cell migration will be defined. 2) The molecular basis of CD26/DPPIV in T-cell function and costimulation...
  22. CD Expression in Prostate Cancer
    Alvin Liu; Fiscal Year: 2004
    ..The CD phenotype for prostate cancer cells is CD10-/CD13-CD24/CD26+/CD38/CD57+/CDw75+/CD107b+, found for many tumors examined...
  23. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  24. QPP: Protease that Prevents Apoptosis in Quiescent Cells
    Brigitte Huber; Fiscal Year: 2007
    ..of combinatorial dipeptide substrate libraries, the structural comparison of human and murine QPP with that of DPP4, and the isolation of a physiological substrate(s) by affinity matrix chromatography...
  25. Does neuropeptide Y (NPY) promote atherosclerosis?
    Zofia Zukowska; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. MINIMAL ENTERAL NUTRIENT REQUIREMENTS IN NEONATES
    Douglas Burrin; Fiscal Year: 2004
    ....
  27. Tumor Invasion and Metastasis Mediated by Cell Surface Proteolysis
    Michael J Wilson; Fiscal Year: 2010
    ..Accomplishment of these aims may empower the design of a new generation of MMP inhibitors targeting the tumor cell surface and provide model systems to test the efficacies of these potential therapeutics. ..
  28. IMMUNOSUPPRESSION IN MYCOBACTERIAL DISEASES
    Zahra Toossi; Fiscal Year: 2001
    ..3. To characterize the T-cell dysfunction of patients with active pulmonary tuberculosis, its relationship to TGF-beta and other suppressive cytokines (IL-10) and its reversal by inhibitors of TGF- beta. ..
  29. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  30. Aging, Angiogenesis, and the Neuropeptide Y (NPY) System
    Joanna Kitlinska; Fiscal Year: 2002
    ..in aged animals; 3) expression of the NPY angiogenic receptors (Y1, Y2, Y5) and its converting enzyme dipeptidyl peptidase IV (DPPIV, which converts NPY to an angiogenically active fragment, NPY3-36) is altered with age 4) age-..
  31. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  32. Ionic Charge and pH Regulation of Apoptotic Signaling
    Mark Segal; Fiscal Year: 2002
    ..This grant will also enhance the research productivity, fiscal independence and career development of the applicant furthering his advancement towards becoming an independent investigator. ..
  33. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  34. Immunologic Mechanisms, Biomarkers and Subsets in Chronic Fatigue Syndrome (CFS)
    MARY A FLETCHER; Fiscal Year: 2011
    ..By defining immune function at the molecular level, we will identify potential biomarkers and targets for intervention with immuno-modulatory therapies and the means to measure the efficacy of these therapies. ..
  35. MOLECULAR RECLASSIFICATION OF PROSTATIC CANCER
    George Michalopoulos; Fiscal Year: 2004
    ..abstract_text> ..
  36. Gut Hormones/Other Circulatory Regulators of Appetite
    Stephen Bloom; Fiscal Year: 2006
    ..Obesity produces over 6,000 excess deaths a week in the USA alone, yet there is no really effective treatment. This meeting is to advance the most promising approach to a safe practical therapy seen in the last 50 years. ..
  37. LENTIVIRAL GENE TRANSFER INTO PANCREATIC BETA-CELLS
    Mark Segal; Fiscal Year: 2003
    ....
  38. Neuropeptide Y in neuroblastoma: growth, angiogenesis and future therapeutics.
    Joanna B Kitlinska; Fiscal Year: 2010
    ..The proposed research will be the first to establish the role and mechanisms of NPY's actions in NBs, and determine prognostic and therapeutic values of the peptide and its Rs. ..
  39. STUDENT PARTNERS IN CANCER RESEARCH AND EDUCATION
    Thomas Kelly; Fiscal Year: 2004
    ..Overall, these students will be able to communicate the importance of cancer detection, prevention, and appropriate treatment in their professional and every-day personal lives, regardless of their eventual specialization or practice. ..
  40. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2009
    ..abstract_text> ..
  41. Early Immune Events in Childhood Asthma
    Lisa Miller; Fiscal Year: 2009
    ..abstract_text> ..
  42. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  43. Role of Eotaxin-3/CCL26 in Allergic Asthma
    Lisa Miller; Fiscal Year: 2008
    ..The identification of chemokines that promote allergic asthma is an important step in the future development of therapeutics to target specific molecules within the airways. [unreadable] [unreadable] [unreadable]..
  44. Neuropeptide Y and dipeptidyl-peptidase IV (CD26) in chronic fatigue syndrome
    Mary Fletcher; Fiscal Year: 2007
    ..One regulator of NPY is dipeptidyl peptidase IV (CD26). Preliminary data from our lab indicate that CD26 concentrations on lymphocytes are abnormally low...
  45. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..

Patents1

  1. Three-dimensional structure of dipeptidyl peptidase iv
    Patent Number: WO2004011640-A1; Date:2004-02-05