dopamine transporter

Summary

Gene Symbol: dopamine transporter
Description: solute carrier family 6 member 3
Alias: DAT, DAT1, PKDYS, sodium-dependent dopamine transporter, DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Species: human

Top Publications

  1. pmc Variation in dopamine genes influences responsivity of the human reward system
    Jean Claude Dreher
    Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 106:617-22. 2009
  2. pmc Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
    E E Forbes
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:60-70. 2009
  3. ncbi The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
    S Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan
    Pharmacogenomics J 1:152-6. 2001
  4. pmc Neurogenetics and pharmacology of learning, motivation, and cognition
    Michael J Frank
    Department of Cognitive, Linguistic and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912 1978, USA
    Neuropsychopharmacology 36:133-52. 2011
  5. doi Working memory plasticity modulated by dopamine transporter genotype
    Yvonne Brehmer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Neurosci Lett 467:117-20. 2009
  6. ncbi Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    B Giros
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 379:606-12. 1996
  7. pmc Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia
    Manju A Kurian
    Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Institute of Biomedical Research, Birmingham, United Kingdom
    J Clin Invest 119:1595-603. 2009
  8. ncbi Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
    Biol Psychiatry 49:333-9. 2001
  9. pmc Genotype and ancestry modulate brain's DAT availability in healthy humans
    Elena Shumay
    Brookhaven National Laboratory, Department of Medicine, Upton, New York, United States of America
    PLoS ONE 6:e22754. 2011
  10. ncbi Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects
    Xavier Caldu
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, and Department of Radiology, Centre de Diagnòstic per la Image, Hospital Clinic de Barcelona, Spain
    Neuroimage 37:1437-44. 2007

Research Grants

  1. Jane V Aldrich; Fiscal Year: 2016
  2. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
  3. MOLECULAR STUDIES OF CATECHOLAMINE TRANSPORTERS
    Susan G Amara; Fiscal Year: 2010
  4. Molecular mechanisms of stimulant abuse
    AURELIO ANTONIO contact GALLI; Fiscal Year: 2010
  5. Traumatic Brain Injury Clinical Trials Network
    Joseph H Ricker; Fiscal Year: 2010
  6. PKC-beta Regulation of the Dopmaine Transporter Trafficking
    Rong Chen; Fiscal Year: 2010
  7. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
  8. Ruth I Wood; Fiscal Year: 2016
  9. Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization
    Jun Zhu; Fiscal Year: 2010
  10. Haley E Melikian; Fiscal Year: 2016

Detail Information

Publications297 found, 100 shown here

  1. pmc Variation in dopamine genes influences responsivity of the human reward system
    Jean Claude Dreher
    Section on Integrative Neuroimaging, Genes, Cognition and Psychosis Program, National Institute of Mental Health, Bethesda, MD 20892 1365, USA
    Proc Natl Acad Sci U S A 106:617-22. 2009
    In humans, dopamine neurotransmission is influenced by functional polymorphisms in the dopamine transporter (DAT1) and catechol-O-methyltransferase (COMT) genes...
  2. pmc Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity
    E E Forbes
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:60-70. 2009
    ..Genetic variants associated with relatively increased striatal DA release (DRD2 -141C deletion) and availability (DAT1 9-repeat), as well as diminished inhibitory postsynaptic DA effects (DRD2 -141C deletion and DRD4 7-repeat), ..
  3. ncbi The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression
    S Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Japan
    Pharmacogenomics J 1:152-6. 2001
    The human dopamine transporter (DAT1) gene contains a variable number of tandem repeats (VNTR) in its 3'-untranslated region (UTR)...
  4. pmc Neurogenetics and pharmacology of learning, motivation, and cognition
    Michael J Frank
    Department of Cognitive, Linguistic and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912 1978, USA
    Neuropsychopharmacology 36:133-52. 2011
    ..a role for genes controlling dopaminergic function in frontostriatal circuitry, including COMT, DARPP-32, DAT1, DRD2, and DRD4...
  5. doi Working memory plasticity modulated by dopamine transporter genotype
    Yvonne Brehmer
    Aging Research Center, Karolinska Institute, Stockholm, Sweden
    Neurosci Lett 467:117-20. 2009
    Dopamine (DA) is implicated in working memory (WM) functioning. Variations in the DA transporter (DAT1) gene (SLC6A3) regulate DA availability in striatum...
  6. ncbi Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    B Giros
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 379:606-12. 1996
    Disruption of the mouse dopamine transporter gene results in spontaneous hyperlocomotion despite major adaptive changes, such as decreases in neurotransmitter and receptor levels...
  7. pmc Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia
    Manju A Kurian
    Department of Medical and Molecular Genetics, University of Birmingham School of Medicine, Institute of Biomedical Research, Birmingham, United Kingdom
    J Clin Invest 119:1595-603. 2009
    Genetic variants of the SLC6A3 gene that encodes the human dopamine transporter (DAT) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder...
  8. ncbi Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder
    C L Barr
    Department of Psychiatry, The Toronto Western Hospital, Toronto, Canada
    Biol Psychiatry 49:333-9. 2001
    ..disorder (ADHD) is often treated using methylphenidate, a psychostimulant that inhibits the dopamine transporter. This led E.H...
  9. pmc Genotype and ancestry modulate brain's DAT availability in healthy humans
    Elena Shumay
    Brookhaven National Laboratory, Department of Medicine, Upton, New York, United States of America
    PLoS ONE 6:e22754. 2011
    The dopamine transporter (DAT) is a principal regulator of dopaminergic neurotransmission and its gene (the SLC6A3) is a strong biological candidate gene for various behavioral- and neurological disorders...
  10. ncbi Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects
    Xavier Caldu
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, and Department of Radiology, Centre de Diagnòstic per la Image, Hospital Clinic de Barcelona, Spain
    Neuroimage 37:1437-44. 2007
    Two limiting factors of dopamine activity are the catechol-o-methyltransferase (COMT) and the dopamine transporter (DAT), which terminate dopamine activity by degradation and uptake, respectively...
  11. doi Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies
    Anna Costa
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Synapse 65:998-1005. 2011
    The human dopamine transporter (DAT) gene (SLC6A3) contains a 40-bp variable number of tandem repeats (VNTR) polymorphism...
  12. doi Dopamine transporter regulates the enhancement of novelty processing by a negative emotional context
    Manuel Garcia-Garcia
    Institute for Brain, Cognition and Behavior IR3C, University of Barcelona, Barcelona, Spain
    Neuropsychologia 48:1483-8. 2010
    ..Forty healthy volunteers were genotyped for the dopamine transporter (DAT) gene SLC6A3 or DAT1 and performed an auditory-visual distraction paradigm in negative and neutral ..
  13. ncbi Association of the dopamine transporter gene with alcoholism
    Michael D Köhnke
    University Hospital of Psychiatry, Osianderstrasse 24, 72076 Tubingen, Germany
    Alcohol Alcohol 40:339-42. 2005
    It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake.
  14. ncbi D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism
    Elizabeth A Bolan
    Integrative Neuroscience Section, National Institute on Drug Abuse Intramural Research Program National Institutes of Health Department of Health and Human Services, Baltimore, MD 21224, USA
    Mol Pharmacol 71:1222-32. 2007
    The dopamine transporter (DAT) terminates dopamine (DA) neurotransmission by reuptake of DA into presynaptic neurons. Regulation of DA uptake by D(2) dopamine receptors (D(2)R) has been reported...
  15. doi Effect of genetic polymorphisms on smoking cessation: a trial of bupropion in Korean male smokers
    Doug Hyun Han
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
    Psychiatr Genet 18:11-6. 2008
    ..Even though bupropion is first-line pharmacological agent for smoking cessation, not all the smokers successfully quit smoking by bupropion. It means other factors like genetic predisposition could contribute to the therapeutic outcome...
  16. doi Variants of the SLC6A3 (DAT1) polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD
    Monika Althaus
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, The Netherlands
    Biol Psychol 85:19-32. 2010
    Although the 10-repeat (10R) variant of the dopamine transporter gene (DAT1 or SLC6A3) is suggested to be a risk allele for Attention Deficit Hyperactivity Disorder (ADHD) no relationships between DAT1 and measures of cognition in ..
  17. doi SPECT imaging of dopamine transporters with (99m)Tc-TRODAT-1 in major depression and Parkinson's disease
    Hao Wu
    Department of Neuropsychiatry, Sir Run Run Shaw Hospital of Medicine College of Zhejiang University, Hangzhou, China
    J Neuropsychiatry Clin Neurosci 23:63-7. 2011
    To investigate dopamine transporter in major depressive disorder and Parkinson's disease, the authors obtained single photon emission computed tomography (SPECT) brain images from 13 patients with major depression, 17 Parkinson's disease ..
  18. doi Association of intron 1 variants of the dopamine transporter gene with schizophrenia
    Chunming Zheng
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing 100005, China
    Neurosci Lett 513:137-40. 2012
    The dopamine transporter (DAT1) gene has been implicated in the pathogenesis of many neuropsychiatric disorders, including schizophrenia...
  19. pmc Association of attention-deficit disorder and the dopamine transporter gene
    E H Cook
    Department of Psychiatry, University of Chicago, IL, USA
    Am J Hum Genet 56:993-8. 1995
    ..The response of ADHD patients to medications that inhibit the dopamine transporter, including methylphenidate, amphetamine, pemoline, and bupropion, led us to consider the dopamine ..
  20. ncbi Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding
    Claus Juul Loland
    Molecular Neuropharmacology Group, Department of Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 279:3228-38. 2004
    Recently we showed evidence that mutation of Tyr-335 to Ala (Y335A) in the human dopamine transporter (hDAT) alters the conformational equilibrium of the transport cycle...
  21. ncbi D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individuals
    U W Preuss
    Pediatric Hospital of Ludwig Maximilians University, Munich, Germany
    Alcohol Alcohol 42:258-66. 2007
    ..Gene Data Bank for Alcoholism(MGBA) was to re-evaluate the potential relation between D2 receptor and dopamine transporter gene haplotypes and quantity-related phenotypes of alcohol consumption (average daily alcohol intake before ..
  22. pmc Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:1224-34. 2009
    ..Both the dopamine transporter (DAT) and dopamine D(2) receptors (encoded by DRD(2)) critically regulate dopamine signaling in the ..
  23. pmc Neural response to working memory load varies by dopamine transporter genotype in children
    Melanie Stollstorff
    Department of Psychology, Georgetown University, Washington, DC, USA
    Neuroimage 53:970-7. 2010
    Inheriting two (10/10) relative to one (9/10) copy of the 10-repeat allele of the dopamine transporter genotype (DAT1) is associated with Attention Deficit Hyperactivity Disorder, a childhood disorder marked by poor executive function...
  24. doi Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Cneter, Durham, NC 27708, USA
    Nicotine Tob Res 10:117-27. 2008
    ..We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes...
  25. pmc Dopamine transporter gene variation modulates activation of striatum in youth with ADHD
    Anne Claude Bedard
    Department of Psychiatry, Mount Sinai School of Medicine, Box 1230, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroimage 53:935-42. 2010
    Polymorphisms in the 3'UTR variable number tandem repeat (VNTR) of exon 15 of the dopamine transporter gene (DAT1) have been linked to attention-deficit hyperactivity disorder (ADHD); moreover, variability in DAT1 3'UTR genotype may ..
  26. doi Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..The dopamine receptor D(2) (DRD2) protein and dopamine transporter (DAT1) protein play regulatory roles in dopamine neurotransmission...
  27. ncbi Effects of genetic variations in the dopaminergic system on fatigue in humans: gender aspects
    N V Malyuchenko
    Biological Faculty, M V Lomonosov Moscow State University, Moscow, Russia
    Bull Exp Biol Med 149:226-32. 2010
    ..the functional status under the effect of intense mental exercise were studied in carriers of different variants of DAT1, DRD2, and COMT genes...
  28. doi Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow?
    Neivo da Silva
    Laboratório de Medicina Nuclear do Complexo Hospitalar Santa Casa LAMENU, Porto Alegre, Brazil
    Clin Nucl Med 36:656-60. 2011
    ..of the dopaminergic system has been suggested by genetic studies that report an overexpression of the dopamine transporter (DAT) gene...
  29. pmc The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors
    Guang Guo
    Department of Sociology, The University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9352. 2010
    This study tests the specific hypothesis that the 9R/9R genotype in the VNTR of the dopamine transporter gene (DAT1) exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R ..
  30. ncbi Dopamine transporter (DAT) genotype (VNTR) and phenotype in extrapyramidal symptoms induced by antipsychotics
    Amalia Lafuente
    Dep Farmacología y Química Terapéutica, Universidad de Barcelona, IDIBAPS, Casanova 143, E 08036 Barcelona, Spain
    Schizophr Res 90:115-22. 2007
    Impaired dopamine transporter (DAT) function may be involved in antipsychotic (AP)-induced extrapyramidal symptoms (EPS). A polymorphism involving a variable number of tandem repeats (VNTR) has been described in the DAT gene (SLC6A3).
  31. ncbi Immunocytochemical localization of the dopamine transporter in human brain
    B J Ciliax
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 409:38-56. 1999
    The dopamine transporter (DAT) was localized in normal human brain tissue by light microscopic immunocytochemistry by using highly specific monoclonal antibodies...
  32. ncbi Association between the dopamine transporter gene and posttraumatic stress disorder
    R H Segman
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Hadassah University Hospital, PO Box 12000, Ein Karem, Jerusalem 91120, Israel
    Mol Psychiatry 7:903-7. 2002
    ..neurotransmission in shaping the responses to stress in animals, this study examined the association of the dopamine transporter (DAT) SLC6A3 3' variable number tandem repeat (VNTR) polymorphism with PTSD...
  33. pmc DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART)
    Rui Mata
    Center for Cognitive and Decision Sciences, Department of Psychology, University of Basel, Basel, Switzerland
    PLoS ONE 7:e39135. 2012
    ..Analogue Risk Task, BART) and a variable number tandem repeat (VNTR) polymorphism in the 3'UTR of the dopamine transporter gene (SLC6A3/DAT1)...
  34. ncbi Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter
    Gonzalo E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:2731-9. 2003
    The dopamine transporter (DAT) is a presynaptic plasma membrane protein responsible for the termination of dopaminergic neurotransmission in the central nervous system...
  35. pmc A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample
    Camila Guindalini
    Medical Research Council Social Genetic and Developmental Psychiatry Research Centre, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Proc Natl Acad Sci U S A 103:4552-7. 2006
    The dopamine (DA) transporter DAT1 is a major target bound by cocaine in brain. We examined the influence of functional genetic variants in DAT1 on cocaine addiction...
  36. ncbi Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder
    T A Greenwood
    Departments of Psychiatry, University of California, San Diego and San Diego VA Medical Center, San Diego, California
    Am J Med Genet 105:145-51. 2001
    A role for the dopamine transporter (DAT) in bipolar disorder is implicated by several lines of pharmacological evidence, as well as suggestive evidence of linkage at this locus, which we have reported previously...
  37. ncbi Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter
    B Giros
    Department of Cell Biology, Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, North Carolina 27710
    Mol Pharmacol 42:383-90. 1992
    We have screened a human substantia nigra cDNA library with probes derived from the rat dopamine transporter. A 3.5-kilobase cDNA clone was isolated and its corresponding gene was located on the distal end of chromosome 5 (5p15.3)...
  38. ncbi The genetic basis for smoking behavior: a systematic review and meta-analysis
    Marcus Munafo
    Department of Clinical Pharmacology, University of Oxford, UK
    Nicotine Tob Res 6:583-97. 2004
    ..The meta-analysis included data on the DRD2, DAT, 5HTT, and CYP2A6 genes and smoking behavior...
  39. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
    ..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release...
  40. pmc Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax
    Seth W Perry
    Center for Neural Development and Disease, Department of Neurology, Child Neurology Division, Graduate Program in Pathology, and Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 30:14153-64. 2010
    ..Here, we further report that Tat disrupts DA transporter (DAT) activity and function, resulting in increased plasma membrane (PM) DAT and increased DAT V(max), without ..
  41. pmc Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT
    M Laura Cremona
    Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    Nat Neurosci 14:469-77. 2011
    ..as Reggie-2, was required for PKC-regulated internalization of members of two different NTT families, the DA transporter (DAT) and the glial glutamate transporter EAAT2, and we identified a conserved serine residue in Flot1 that is ..
  42. pmc Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism
    C Saunders
    Departments of Pharmacology and Biochemistry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78248, USA
    Proc Natl Acad Sci U S A 97:6850-5. 2000
    The dopamine transporter (DAT) is a target of amphetamine (AMPH) and cocaine. These psychostimulants attenuate DAT clearance efficiency, thereby increasing synaptic dopamine (DA) levels...
  43. ncbi Dopamine transporter genotype as a risk factor for obesity in African-American smokers
    Leonard H Epstein
    Department of Pediatrics and Sports Medicine Institute, University at Buffalo School of Medicine, New York 14214, USA
    Obes Res 10:1232-40. 2002
    ..To assess the association between a polymorphism related to dopamine function, dopamine transport (SLC6A3), and obesity in smokers...
  44. ncbi Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype
    Rosalind J Neuman
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 61:1320-8. 2007
    ..We examined the joint effects of genetic and prenatal substance exposures on DSM-IV and population-defined subtypes of ADHD...
  45. ncbi A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder
    Binrang Yang
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Department of Psychology, Sun Yat Sen University, Guangzhou, China
    Am J Med Genet B Neuropsychiatr Genet 144:541-50. 2007
    The association between the 10-repeat allele of the dopamine transporter gene (DAT) and attention deficit hyperactivity disorder (ADHD) is uncertain...
  46. pmc How dopamine transporter interacts with dopamine: insights from molecular modeling and simulation
    Xiaoqin Huang
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA
    Biophys J 93:3627-39. 2007
    ..and molecular dynamics simulations, we have developed three-dimensional (3D) structural models of both dopamine transporter and dopamine transporter-dopamine complex in the environment of lipid bilayer and solvent water...
  47. ncbi Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching
    Erika M Adkins
    Molecular Neuropharmacology Group, Department of Neuroscience and Pharmacology and Center for Pharmacogenomics, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    Biochemistry 46:10484-97. 2007
    To investigate microdomain association of the dopamine transporter (DAT), we employed FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after photobleaching)...
  48. pmc Dopamine and opioid gene variants are associated with increased smoking reward and reinforcement owing to negative mood
    Kenneth A Perkins
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Behav Pharmacol 19:641-9. 2008
    ..These results warrant replication but provide the first evidence for genetic associations with the acute increase in smoking reward and reinforcement owing to negative mood...
  49. doi Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay
    Suzanne E Stevens
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Am J Med Genet B Neuropsychiatr Genet 150:753-61. 2009
    ..Individuals were genotyped for polymorphisms in the dopamine D4 receptor (DRD4 48-bp VNTR in exon 3) and dopamine transporter gene (DAT1 haplotypes combining a 40-bp VNTR in 3'UTR and a 30-bp VNTR in intron 8)...
  50. pmc Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder
    Julia K Pinsonneault
    Department of Pharmacology, The Ohio State University, Columbus, OH 43210 1239, USA
    Neuropsychopharmacology 36:1644-55. 2011
    The gene encoding the dopamine transporter (DAT) has been implicated in CNS disorders, but the responsible polymorphisms remain uncertain...
  51. pmc Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity
    I D Waldman
    Department of Psychology, Emory University, Atlanta, Georgia, USA
    Am J Hum Genet 63:1767-76. 1998
    ..In this study, we used four analytic strategies to examine the association and linkage of the dopamine transporter gene (DAT1) and ADHD...
  52. ncbi Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1
    G E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 30:121-34. 2001
    ..In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex...
  53. ncbi Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR
    Jonathan Mill
    Social, Genetic, and Developmental Research Centre, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom
    Am J Med Genet 114:975-9. 2002
    ..10-repeat allele of a variable number tandem repeat (VNTR) in the 3'-untranslated region (3'-UTR) of the dopamine transporter gene (DAT1) is associated with a range of psychiatric phenotypes, most notably, attention deficit ..
  54. pmc N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux
    Habibeh Khoshbouei
    Department of Molecular Physiology and Biophysics and Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, USA
    PLoS Biol 2:E78. 2004
    Amphetamine (AMPH) elicits its behavioral effects by acting on the dopamine (DA) transporter (DAT) to induce DA efflux into the synaptic cleft...
  55. ncbi Syntaxin 1A and receptor for activated C kinase interact with the N-terminal region of human dopamine transporter
    Ki Hwan Lee
    Department of Biochemistry, College of Medicine, Hanyang University, Seoul, Korea
    Neurochem Res 29:1405-9. 2004
    The dopamine transporter (DAT) regulates the extent and duration of dopamine receptor activation through sodium-dependant reuptake of dopamine into presynaptic neurons, resulting in termination of dopaminergic neurotransmission...
  56. ncbi Effects of dopamine D2 receptor (DRD2) and transporter (SLC6A3) polymorphisms on smoking cue-induced cigarette craving among African-American smokers
    J Erblich
    Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Mol Psychiatry 10:407-14. 2005
    ..Smokers carrying either the DRD2 (D2 dopamine receptor gene) TaqI A1 RFLP or the SLC6A3 (dopamine transporter gene) 9-repeat VNTR polymorphisms had stronger cue-induced cravings than noncarriers (Ps <0.05 and 0...
  57. ncbi Disruption of the interaction of alpha-synuclein with microtubules enhances cell surface recruitment of the dopamine transporter
    Christophe Wersinger
    Department of Pediatrics, Georgetown University, Washington, DC 20007, USA
    Biochemistry 44:13612-24. 2005
    ..of alpha-synuclein is the maintenance of dopamine homeostasis, partly through a negative modulation of dopamine transporter (DAT) activity, by reducing its level at the cell surface...
  58. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ..number of tandem repeats (VNTR) polymorphism exists in the 15th exon of DAT1, the gene encoding the human dopamine transporter (DAT)...
  59. ncbi A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse
    S Cevoli
    Department of Neurological Sciences, University of Bologna Medical School, Bologna, Italy
    Eur J Neurol 13:1009-13. 2006
    ..a genetic association study using four functional polymorphisms of the dopamine receptor 4 (DRD4), dopamine transporter (DAT), mono-amino-oxidase A (MAOA) and cathecol-O-methyl-transferase (COMT) genes in 103 patients with ..
  60. pmc Gene-gene interaction associated with neural reward sensitivity
    Juliana Yacubian
    NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 104:8125-30. 2007
    ..prefrontal cortex and ventral striatum to study how individual variation in genes contributing to DA reuptake [DA transporter (DAT)] and degradation [catechol-o-methyltransferase (COMT)] influences reward processing...
  61. ncbi Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissue
    Keeley J Brookes
    MRC Social Genetic Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 144:1070-8. 2007
    ..Association studies have repeatedly implicated the dopamine transporter (DAT1) gene, and in particular the 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism ..
  62. doi Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation
    Sarah Durston
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neurosciences, Neuroimaging Lab, HP A 01 468, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 47:61-7. 2008
    The dopamine transporter (DAT1) gene has been implicated in attention-deficit/hyperactivity disorder (ADHD), although the mechanism by which it exerts its effects remains unknown...
  63. doi A common haplotype at the dopamine transporter gene 5' region is associated with attention-deficit/hyperactivity disorder
    Julia P Genro
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Am J Med Genet B Neuropsychiatr Genet 147:1568-75. 2008
    The dopamine transporter (DAT) is the major site of methylphenidate action, which is one of the main drugs used to treat attention-deficit/hyperactivity disorder (ADHD)...
  64. doi Candidate gene studies of ADHD: a meta-analytic review
    Ian R Gizer
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Road, Room 5015 Genetic Medicine Building CB 7264, Chapel Hill, NC 27599 7264, USA
    Hum Genet 126:51-90. 2009
    ..Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25...
  65. doi Associations between polymorphisms in dopamine neurotransmitter pathway genes and pain response in healthy humans
    Roi Treister
    The Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pain 147:187-93. 2009
    ..promoter region of the monoamine oxidase-A gene (MAO-A), 40-bp repeat in the 3'-untranslated region of the dopamine transporter gene (DAT-1), and 48-bp repeat in the exon 3 of the dopamine receptor 4 gene (DRD4) were examined...
  66. pmc Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD
    Barbara Franke
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:656-64. 2010
    ..DAT1, encoding the dopamine transporter, is one of the most frequently studied genes in ADHD, though results have been inconsistent...
  67. pmc Striatal dopamine mediates the interface between motivational and cognitive control in humans: evidence from genetic imaging
    Esther Aarts
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands
    Neuropsychopharmacology 35:1943-51. 2010
    ..We fill this gap by using fMRI, a novel behavioral paradigm and a common polymorphism in the DAT1 gene (SLC6A3)...
  68. pmc The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter
    Jufang Shan
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 6:e16350. 2011
    The dopamine transporter (DAT), a member of the neurotransmitter:Na(+) symporter (NSS) family, terminates dopaminergic neurotransmission and is a major molecular target for psychostimulants such as cocaine and amphetamine, and for the ..
  69. doi The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traits
    A Kazantseva
    Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, 71, Prospekt Oktyabrya, Ufa 450054, Russia
    Prog Neuropsychopharmacol Biol Psychiatry 35:1033-40. 2011
    ..002). Our findings provide evidence for a modifying effect of gender on the associations between dopamine system genes and approach-related traits (in men) and Persistence (in women)...
  70. pmc Modulation of inhibition of return by the dopamine D2 receptor agonist bromocriptine depends on individual DAT1 genotype
    Ariel Rokem
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Cereb Cortex 22:1133-8. 2012
    ..IOR depends on striatal dopamine (DA) levels: It varies with different alleles of the DA transporter gene DAT1 and is reduced in patients with Parkinson's disease, a disease characterized by reduced striatal ..
  71. pmc Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults
    Andrew J Levine
    National Neurological AIDS Bank, Department of Neurology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, USA
    J Clin Exp Neuropsychol 34:78-91. 2012
    Dopaminergic dysfunction is a putative mechanism underlying HIV-associated neurocognitive disorders. Dopamine transporter (DAT), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) have been specifically ..
  72. ncbi Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
    Philip Asherson
    MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry, London, SE5 8AF UK
    Am J Psychiatry 164:674-7. 2007
    The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across ..
  73. doi Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD
    B Franke
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1576-9. 2008
    ..The gene that has received most attention in ADHD genetics is SLC6A3/DAT1 encoding the dopamine transporter. In the current study we attempted to replicate in adults with ADHD the reported association of a 10-6 ..
  74. pmc Dopamine transporter genetic variants and pesticides in Parkinson's disease
    Beate R Ritz
    Department of Epidemiology, Center for Occupational and Environmental Health, UCLA School of Public Health, University of California at Los Angeles, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 117:964-9. 2009
    Research suggests that independent and joint effects of genetic variability in the dopamine transporter (DAT) locus and pesticides may influence Parkinson's disease (PD) risk.
  75. pmc Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity
    Elena Shumay
    Brookhaven National Laboratory, Medical Department, Upton, New York, USA
    PLoS ONE 5:e11067. 2010
    Human dopamine transporter gene (DAT1 or SLC6A3) has been associated with various brain-related diseases and behavioral traits and, as such, has been investigated intensely in experimental- and clinical-settings...
  76. pmc Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 35:2193-202. 2010
    ..a common variable number of tandem repeats (VNTR) polymorphism in the 3' untranslated region (UTR) of the dopamine transporter gene (SLC6A3) has been repeatedly associated with the disorder...
  77. ncbi Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding
    Z B Pristupa
    Department of Psychiatry, University of Toronto, Ontario
    Mol Pharmacol 45:125-35. 1994
    ..state of the dopamine (DA) transporter is identical to sites mediating the specific binding of selective DA transporter radioligands...
  78. ncbi Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations
    D J Vandenbergh
    Molecular Neurobiology Branch, National Institute on Drug Abuse, NIH, USA
    Mol Psychiatry 5:283-92. 2000
    The dopamine transporter (DAT) provides major regulation of the synaptic levels of dopamine and is a principal target of psychostimulant drugs...
  79. ncbi Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder
    Tatiana Roman
    Department of Genetics, Federal University of Rio Grande do Sul, Brazil
    Pharmacogenetics 12:497-9. 2002
    ..to evaluate whether a previously reported association between homozygosity for the 10-repeat allele of the dopamine transporter gene (10/10) and poor response to methylphenidate (MPH) would be replicated in a sample of Brazilian ..
  80. ncbi Smoking status and the human dopamine transporter variable number of tandem repeats (VNTR) polymorphism: failure to replicate and finding that never-smokers may be different
    David J Vandenbergh
    Department of Biobehavioral Health, Center for Developmental and Health Genetics, The Pennsylvania State University, 225 Research Building E, University Park, PA 16802 2321, USA
    Nicotine Tob Res 4:333-40. 2002
    Cigarette smoking, like many addictive behaviors, has been shown to have a genetic component. The dopamine transporter (DAT) gene (SLC6A3) encodes a protein that regulates synaptic levels of dopamine in the brain and is a candidate gene ..
  81. ncbi N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization
    Charlotta Granas
    Molecular Neuropharmacology Group, Department of Pharmacology, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 278:4990-5000. 2003
    ..structural basis of phosphorylation and its putative role in internalization were investigated in the human dopamine transporter (hDAT)...
  82. ncbi Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls
    S Durston
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Mol Psychiatry 10:678-85. 2005
    ..We show that the DAT1 gene, a gene expressed predominantly in the basal ganglia, preferentially influences caudate volume, whereas the ..
  83. ncbi Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample
    K M Cornish
    Neuroscience Laboratory for Research and Education in Developmental Disorders, McGill University, Montreal, Canada
    Mol Psychiatry 10:686-98. 2005
    Association between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of the dopamine transporter gene (DAT1) has been reported in independent clinical samples using a categorical clinical definition of ADHD...
  84. ncbi Dopamine transporter genotype and methylphenidate dose response in children with ADHD
    Mark A Stein
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Neuropsychopharmacology 30:1374-82. 2005
    ..MPH acts primarily by inhibiting the dopamine transporter (DAT), a protein responsible for the reuptake of dopamine from the synapse into presynaptic terminals...
  85. ncbi Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease
    Samir N Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Pharmacogenet Genomics 15:659-68. 2005
    The dopamine transporter (DAT) plays a critical role in dopaminergic neurotransmission and is also the major site of action for some drugs of abuse...
  86. ncbi A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
    J Hebebrand
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Mol Psychiatry 11:196-205. 2006
    ..The locus of the solute carrier 6A3 (SLC6A3; dopamine transporter 1; DAT1) localizes to 5p15.33; the gene has repeatedly been implicated in the etiology of ADHD...
  87. ncbi Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples
    T A Greenwood
    Department of Psychiatry, University of California at San Diego, and San Diego VA Health Care System, La Jolla, CA 92093, USA
    Mol Psychiatry 11:125-33, 115. 2006
    The dopamine transporter (DAT) is the site of action of stimulants, and variations in the human DAT gene (DAT1) have been associated with susceptibility to several psychiatric disorders including attention deficit hyperactivity disorder (..
  88. ncbi An association between the DAT1 polymorphism and smoking behavior in young adults from the National Longitudinal Study of Adolescent Health
    David S Timberlake
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO 80309 0447, USA
    Health Psychol 25:190-7. 2006
    ..The 9-repeat allele of the dopamine transporter gene polymorphism (DAT1) was inversely associated with smoking in samples that included all subjects and ..
  89. ncbi A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients
    Peter R Joyce
    Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Psychol Med 36:807-13. 2006
    ..We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD...
  90. ncbi Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo
    Tomas Drgon
    Molecular Neurobiology Branch, NIDA IRP, NIH, DHSS, Box 5180, Baltimore, Maryland 21224, USA
    Cell Mol Neurobiol 26:875-89. 2006
    1. Individuals display significant differences in their levels of expression of the dopamine transporter (DAT; SLC6A3)...
  91. pmc An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood
    Russell A Barkley
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 141:487-98. 2006
    ..candidate gene polymorphisms have been implicated in attention deficit hyperactivity disorder (ADHD), including DAT1 40bp VNTR, DRD4 7+, and DBH TaqI A2 alleles...
  92. ncbi RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis
    Tatiana Sorkina
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    J Neurosci 26:8195-205. 2006
    The function of the dopamine transporter (DAT) to terminate dopamine neurotransmission is regulated by endocytic trafficking of DAT...
  93. ncbi Valproate robustly increases Sp transcription factor-mediated expression of the dopamine transporter gene within dopamine cells
    Jun Wang
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Eur J Neurosci 25:1982-6. 2007
    ..a drug used in the treatment of mania and bipolar disorders, epilepsies, and addictions, may modulate dopamine transporter (DAT) function, yet the effects of valproate on DAT gene expression have not been directly assessed...
  94. ncbi Association between dopamine transporter genotypes and smoking cessation: a meta-analysis
    John A Stapleton
    Tobacco Research Group, Department of Psychological Medicine, Kings College London, Institute of Psychiatry, London, UK
    Addict Biol 12:221-6. 2007
    This review assessed the evidence of an association between genotypes of the dopamine transporter (DAT1, SLC6A3) 3' untranslated region (3'UTR) variable number of tandem repeats (VNTR) and smoking cessation...
  95. doi Association between polymorphisms in the dopamine transporter gene and depression: evidence for a gene-environment interaction in a sample of juvenile detainees
    Gerald J Haeffel
    University of Notre Dame, Notre Dame, IN 46556, USA
    Psychol Sci 19:62-9. 2008
    ..Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15...
  96. pmc Genes implicated in serotonergic and dopaminergic functioning predict BMI categories
    Bernard F Fuemmeler
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Obesity (Silver Spring) 16:348-55. 2008
    ..Interactions with gender and race/ethnicity were also examined...
  97. doi Polymorphism in environment responsive genes and association with Parkinson disease
    Madhu Singh
    Developmental Toxicology Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Mol Cell Biochem 312:131-8. 2008
    ..allele frequencies was observed for manganese-superoxide dismutase (MnSOD), dopamine receptor-D2(DRD2), and dopamine transporter (DAT) genes between controls and PD cases...
  98. pmc Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia
    Ikwunga Wonodi
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, 21228, USA
    Am J Med Genet B Neuropsychiatr Genet 150:282-9. 2009
    ..Recent evidence implicates the dopamine transporter gene (DAT1) in modulating cortical dopamine and associated neurocognitive functions...
  99. doi A review and analysis of the relationship between neuropsychological measures and DAT1 in ADHD
    Nanda N J Rommelse
    Department of Clinical Neuropsychology, VU University Amsterdam, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:1536-46. 2008
    Meta-analyses indicate that the gene coding for the dopamine transporter (DAT1 or SLC6A3) is associated with an increased risk for ADHD. The mechanisms of this gene for ADHD are unclear...
  100. pmc Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age
    M J Bannon
    Department of Psychiatry Cellular and Clinical Neurobiology Program, Wayne State University School of Medicine, Detroit, MI
    Proc Natl Acad Sci U S A 89:7095-9. 1992
    The dopamine transporter is the primary means of inactivating synaptic dopamine as well as a major site of action for psychostimulants (such as cocaine and amphetamine) and for neurotoxins that induce parkinsonism...
  101. ncbi A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs
    D J Vandenbergh
    Laboratory of Molecular Neurobiology, National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224
    Brain Res Mol Brain Res 15:161-6. 1992
    We describe a cDNA for the human dopamine transporter, which has been implicated in several human disorders linked to dopaminergic function...

Research Grants89

  1. Jane V Aldrich; Fiscal Year: 2016
    ..Cocaine is known to exert its action in part by blocking the dopamine transporter that is responsible for the termination of dopamine signaling, thereby enhancing the dopamine signaling ..
  2. Dopamine Transporter Structure and Function
    Christopher K Surratt; Fiscal Year: 2010
    ..attention deficit therapeutics and other CNS-acting agents is also an unfulfilled goal of the dopamine transporter (DAT) research field...
  3. MOLECULAR STUDIES OF CATECHOLAMINE TRANSPORTERS
    Susan G Amara; Fiscal Year: 2010
    ..For the dopamine transporter (DAT) we have found that regulated internalization proceeds through one of two apparently distinct ..
  4. Molecular mechanisms of stimulant abuse
    AURELIO ANTONIO contact GALLI; Fiscal Year: 2010
    ..g. Parkinson's disease), are a tremendous public health burden. The dopamine transporter, which regulates extracellular brain dopamine, is the major molecular target of several psychoactive drugs, ..
  5. Traumatic Brain Injury Clinical Trials Network
    Joseph H Ricker; Fiscal Year: 2010
    ..effects of methylphenidate on executive functioning and outcome after TBI and the influence of gender and dopamine transporter genotype on therapeutic efficacy of this drug...
  6. PKC-beta Regulation of the Dopmaine Transporter Trafficking
    Rong Chen; Fiscal Year: 2010
    ..in the synapse is primarily terminated by removal of dopamine (DA) into presynaptic nerve terminals via the dopamine transporter (DAT), one of a superfamily of Na+/Cl--dependent neurotransmitter transporters...
  7. Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symporters
    Jonathan A Javitch; Fiscal Year: 2013
    ..of our structural and functional findings in bacterial transporters to understanding the function of SERT and DAT. We will: a) demonstrate the essential functional role of the S2 site in these human transporters, and b) use a Cl--..
  8. Ruth I Wood; Fiscal Year: 2016
    ..these responses by measuring levels of tyrosine hydroxylase, dopamine D1 and D2 receptors, and the dopamine transporter. Together, these studies will provide insight into the potential for AAS to enhance motivation and reward, ..
  9. Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization
    Jun Zhu; Fiscal Year: 2010
    ..2008). The preliminary results show that in vitro exposure to the Tat protein decreases DA transporter (DAT) function in rat striatum...
  10. Haley E Melikian; Fiscal Year: 2016
    ..synaptic release, DA availability is limited by presynaptic reuptake, mediated by the plasma membrane DA transporter (DAT)...
  11. MAARTEN E REITH; Fiscal Year: 2016
    The dopamine transporter (DAT) clears extracellular dopamine thereby limiting its lifetime after release. The clearance process consists of DAT translocating dopamine from the outside to the inside of dopaminergic neurons...
  12. CIRCADIAN SYSTEM AND PRENATAL COCAINE IN ZEBRAFISH
    Irina V Zhdanova; Fiscal Year: 2013
    ..rate, dopamine levels, expression of the circadian genes and those encoding for the melatonin receptors, dopamine transporter, cyclin-dependent kinases, cyclin A and growth hormone will be evaluated throughout development and ..
  13. Alexander D Sorkin; Fiscal Year: 2015
    ..Because DAT'functions near synaptic areas of the neuronal plasma membrane, regulation of subcellular targeting and surface ..
  14. Subramaniam Ananthan; Fiscal Year: 2014
    ..in the central nervous system, the biogenic amine transporters in general, and the dopamine (DA) transporter (DAT) in particular, play a key role in addiction to stimulant drugs of abuse and in a number of psychiatric illnesses...
  15. Randy D Blakely; Fiscal Year: 2016
    ..DA signaling is tightly controlled by a presynaptic, DA transporter (DAT) that is a major target for addictive psychostimulants such as cocaine and amphetamine (AMPH), as well as ..
  16. Forward Genetics and the Presynaptic Dopamine Transporter
    Randy D Blakely; Fiscal Year: 2010
    ..The presynaptic DA transporter (DAT) is the primary mode by which DA signaling is terminated and is a direct target for cocaine and ..
  17. HIV-Induced Dopamnergic Changes and Methamphetamine Toxicity Mediated through Mic
    ERICK THOMAS TATRO; Fiscal Year: 2012
    ..are chemically similar to dopamine and cause dopaminergic dysfunction in the brain by reversing the dopamine transporter and thus activating dopamine receptors and cause accumulation of high concentrations of dopamine in the ..
  18. Dopamine Transporter Palmitoylation
    JAMES DARREN FOSTER; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: The proposed research is relevant to public health because activity of the dopamine transporter (DAT) is essential for normal dopaminergic neurotransmission and defects in its regulation may be involved ..
  19. Circadian Modulation of Drug-Seeking Behavior
    Heiko T Jansen; Fiscal Year: 2011
    ..We have also discovered diurnal variation in expression of the dopamine transporter (DAT) protein...
  20. Non-Tropane Irreversible Dopamine Transporter Ligands
    DAVID JOHN LAPINSKY; Fiscal Year: 2010
    ..This prodigious void can be linked to sparse information on the 3-D structure and function of the dopamine transporter (DAT), which pharmacological and behavioral studies indicate is the brain receptor chiefly responsible for ..
  21. Jonathan A Javitch; Fiscal Year: 2016
    ..DA reuptake by the DA transporter (DAT) is a principal mechanism for terminating dopaminergic transmission, and this protein is the primary ..
  22. DANIEL BERMINGHAM; Fiscal Year: 2015
    ..The cocaine-sensitive DA transporter (DAT) is a critical determinant of presynaptic DA homeostasis as well as in limiting the actions of DA in ..
  23. Rosemarie M Booze; Fiscal Year: 2015
    ..The ability of estrogen/soy isoflavones+ cocaine to produce DAT dysfunction/protection under physiological conditions will be assessed and the behavioral/pathological consequences ..
  24. Amphetamine Acts as a Molecular Stent in the Dopamine Transporter
    Louis J De Felice; Fiscal Year: 2010
    ..Amphetamine acts as a Molecular Stent in the Dopamine Transporter By introducing the term 'molecular stent'in connection with amphetamine and the dopamine ..
  25. Individual Differences in Cocaine Activation/Reward and the Dopamine Transporter
    NANCY RUTLEDGE ZAHNISER; Fiscal Year: 2013
    ..why individuals differ in cocaine-induced activation and, specifically, i) how the dopamine (DA) trans- porter (DAT) contributes to this differential responsiveness and ii) how this individual variability is predictive of cocaine ..
  26. Sammanda Ramamoorthy; Fiscal Year: 2014
    ..The dopamine transporter (DAT), a membrane protein that clears dopamine (DA) released into the extracellular space is a target of ..
  27. The Neurotransmitter: Sodium Symporter Permeation Pathway
    Lei Shi; Fiscal Year: 2012
    ..the rewarding properties ofthe abused drugs, cocaine and amphetamine, are due mainly to its inhibition of dopamine transporter (DAT);the antidepressant effect of imipramine is exerted on serotonin transporter (SERT)...
  28. Michael J Bannon; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The dopamine transporter (DAT) is a plasma membrane protein that limits dopamine (DA) neurotransmission in the brain and, in doing so, modifies human behavior...
  29. Adolescent risk-taking, dopamine signaling, and cocaine: a vicious circle
    Marci R Mitchell; Fiscal Year: 2012
    ..between adolescent risk taking and cocaine use, with particular focus on D2-like receptors and the dopamine transporter, which have been linked to both risk taking and cocaine use in preliminary and previously published data...
  30. ZHICHENG CARL LIN; Fiscal Year: 2016
    ..by applicant): The overall goal of this proposal is to dissect transcription mechanisms in the human dopamine transporter gene (hDAT)...
  31. Structural and Mechanistic Characterization of Neurotransmitter Reuptake Inhibiti
    DANENG WANG; Fiscal Year: 2012
    ..These proteins include the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT)...
  32. Kent A Kiehl; Fiscal Year: 2014
    ..individuals, and to explore the relationship between the functionality of these processes and dopamine transporter and receptor polymorphisms...
  33. Extinction of Limbic Activation to "Unseen" Cocaine Cues
    Anna Rose Childress; Fiscal Year: 2010
    ..that the limbic response to drug cues is much stronger in carriers of the "inefficient" variant of the dopamine transporter (DAT 9 VNTR), we will determine the contribution of genetic variations in DA transmission for the response ..
  34. Haley E Melikian; Fiscal Year: 2016
    ..Rather, transporters are subject to robust constitutive endocytic trafficking. The dopamine transporter (DAT) is acutely modulated by protein kinase C (PKC) activation and exposure to psychostimulants cocaine ..
  35. D2 Receptor and Food Restriction Regulation of Dopamine Release by Amphetamine
    Kevin Erreger; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The dopamine transporter (DAT) is the plasmalemmal membrane protein that mediates the inactivation of released dopamine (DA) through its reuptake...
  36. Phosphatidylinositol 3 Kinase Signaling Regulates the Amphetamine Actions
    NICOLE KATHRYN SPEED; Fiscal Year: 2010
    ..By acting on the DAT, AMPH attenuates DA clearance efficiency and induces reverse transport of DA...
  37. Methylphenidate, opioid receptors and addiction
    Jinmin Zhu; Fiscal Year: 2011
    ..cocaine share a common dopaminergic mechanism of action (both the compounds interfere with the action of dopamine transporter and increase extracellular dopamine) we hypothesize that opioid receptor signaling plays a critical role in ..
  38. Circadian Influences in Cocaine Reinforcement
    CARSON VIRGINIA DOBRIN; Fiscal Year: 2010
    ..Specifically, I will use FSCV to determine whether DA transporter (DAT) activity demonstrates a circadian rhythm...
  39. Heavy Metal and Drug Self-Administration: Mechanisms
    PAUL JEFFERSON WELLMAN; Fiscal Year: 2010
    ..3) and, employing in situ hybridization techniques, animals will be processed for DA D1-like, DA D2-like, and DA transporter (DAT) mRNA espression. Similarly, Glu receptor expression will be assessed in lead-exposed animals...
  40. Mechanism of drug addiction
    Howard H Gu; Fiscal Year: 2013
    ..Cocaine has 3 high affinity targets in the brain, dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET)...
  41. Functional Properties of Protein Segments in Receptors and Transporters
    Harel Weinstein; Fiscal Year: 2013
    ..to study computationally the involvement of key loops in the modulation of function by transporters including DAT, which is the target of cocaine and amphetamine...
  42. SIDNEY S NEGUS; Fiscal Year: 2016
    ..e., a dopamine releaser via the human dopamine transporter (hDAT), while the other component (MDPV) is cocaine-like, acting as an hDAT blocker...
  43. Amphetamine Regulation of DAT Function in c.elegans
    Lucia Carvelli; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The dopamine transporter (DAT), the protein which carries out the DA reuptake process at the plasma membrane, is the major molecular ..
  44. The dopamine transporter and ions, substrates, blockers
    MAARTEN E REITH; Fiscal Year: 2010
    ..by DA 13261-01 through 05), we have studied the impact of Na+ and Cl- on dopamine (DA) binding to the human DA transporter (hDAT) and the role of membrane potential along with transmembrane ion gradients;substrate-like compounds with ..
  45. Jun Zhu; Fiscal Year: 2016
    ..Presynaptic DA transporter (DAT), which is critical for neurocognitive function, is a major molecular target for both Tat and cocaine to ..
  46. Harel Weinstein; Fiscal Year: 2015
    ..cell components are responsible, as a class - the Neurotransmitter : Sodium Symporter (NSS) - and individually (DAT, SERT, NET) for major aspects of neuronal function in the brain...
  47. Edda Thiels; Fiscal Year: 2014
    ..Dopaminergic signaling is terminated primarily by the re-uptake of the transmitter via a plasma membrane DA transporter (DAT). This protein is also the main target of widely abused psychostimulants, such as cocaine and amphetamine...
  48. ANNETTE FLECKENSTEIN; Fiscal Year: 2014
    ..The vesicular monoamine transporter-2 and the dopamine transporter are principal targets of these agents...
  49. Proteomic Biosignatures of Chronic Drug Exposure
    Howard Schulman; Fiscal Year: 2010
    ..Rats will receive treatment with cocaine or a non-addictive dopamine transporter inhibitor, or morphine, or saline according to a 14 day escalating dose schedule (chronic exposure) and ..
  50. Non-transporter cocaine mechanisms in dopamine system
    Fu Ming Zhou; Fiscal Year: 2010
    ..its psychostimulant and behavioral effects through inhibition of monoamine transporters, dopamine transporters (DAT) in particular...
  51. Michael A Nader; Fiscal Year: 2016
    ..examine the effects of chronic cocaine self-administration on dopamine (DA) D2/D3 receptors and DA transporters (DAT), brain systems that have been well characterized in males, but not females...
  52. Cognitive impact of cocaine cues and agonist treatment approaches
    Charles W Bradberry; Fiscal Year: 2013
    ..implicated in attentional processing, and recent evidence demonstrates an inverse correlation between the dopamine transporter and default network deactivation...
  53. DJ-1-Dopamine Transporter Interactions in Models of Addiction
    AMY BEATRICE MANNING-BOG; Fiscal Year: 2012
    ..Cellular localization of the dopamine transporter (DAT) regulates dopamine uptake activity and thus represents a target mechanism underlying addiction...
  54. Modafinil and Escitalopram for Cocaine Addiction
    Richard De La Garza; Fiscal Year: 2010
    ..Recent data indicates that during chronic treatment modafinil produces substantial dopamine transporter (DAT) inhibition...
  55. The effect of methylphenidate use and abuse on dopamine system kinetics
    ERIN SUE CALIPARI; Fiscal Year: 2013
    ..Thus, MPH possesses DAT interactions that are similar, in part, with other psychostimulants such as COC and AMPH...
  56. Dendritic DAT activity monitored with fluorescent biosensors
    SUSAN L INGRAM OSBORN; Fiscal Year: 2012
    ..in reward pathways of the brain and their abuse potential is closely correlated with their affinity for the dopamine transporter (DAT)...
  57. JAMIE HANNAH ROSE; Fiscal Year: 2015
    ..We have used this model to show that extended exposure to COC results in a pharmacodynamic tolerance of the dopamine transporter (DAT)...
  58. Nigrostriatal Dopamine Function
    JAMES TEPPER; Fiscal Year: 2009
    ..In primates essentially all of these neurons also express the DA transporter (DAT) suggesting strongly that they are DAergic...
  59. Mechanisms of Selective Neurodegeneration in Parkinson Disease
    Xugang Xia; Fiscal Year: 2010
    ..To test proposed mechanisms of dopaminergic neuron death in PD, we have created two novel mouse lines: DAT-CreERT2 transgenic mouse and conditional VMAT2 knockout mouse...
  60. JOEL SYNES PERLMUTTER; Fiscal Year: 2016
    ..striatal uptake of [18F]FD (primarily reflecting decarboxylase activity), [11C]CFT (a dopamine transport marker, DAT) and [11C]DTBZ (a vesicular monoamine transporter type 2) reflect striatal dopamine content but only reflect nigral ..
  61. MOLECULAR BASIS OF SELECTED GXE EFFECTS IN COMBINED TYPE ADHD
    Alexandre A Todorov; Fiscal Year: 2012
    ..of maternal smoking during pregnancy and certain genotypes of dopamine pathway genes (including the DRD4, dopamine transporter and CHRNA4 genes)...
  62. Presynaptic Mechanisms Regulating the Dopamine Transporter
    JAMES A HARDAWAY; Fiscal Year: 2013
    ..Temporal and spatial regulation of synaptic DA signaling is controlled by the presynaptic DA transporter (DAT)...
  63. Inducible recombination and gene expression in specific neurotransmitter systems
    Steven A Thomas; Fiscal Year: 2012
    ..will be utilized: for the adrenergic system - dopamine 2- hydroxylase, for the dopaminergic system - dopamine transporter, for the serotonergic system - tryptophan hydroxylase 2, and for the orexinergic system - orexin...
  64. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..HFE, transferrin, DMT-1), cholesterol metabolism (apolipoprotein E), neurotransmitter metabolism (dopamine transporter, dopamine D4 receptor, norepinephrine transporter, monoamine oxidase, catechol O-methyltransferase, NMDA ..
  65. The Influence of Dopaminergic Genetic Variants on D2-like Receptors in Drinkers
    Amira K Brown; Fiscal Year: 2011
    ..Met, DRD4 VNTR 7-repeat allele and DAT VNTR SCL39 9-repeat (vs...
  66. Characterizing Two Distinct ADHD Neurobiologies with fMRI
    Michael C Stevens; Fiscal Year: 2012
    ..cognitive domains, fMRI measurement of response inhibition and reward system brain activity, and genotyping DAT1, DRD4, plus several other dopamine-related genetic markers previously linked to ADHD...
  67. Variability in Brain Function Underlying Motivated Behavior in Adolescence
    Beatriz Luna; Fiscal Year: 2013
    ..to have impact on reward and cognitive control systems are catechol-o-methyltransferase (COMT) and the dopamine transporter (DAT1)...
  68. In Vivo Detection of Neuronal Activity
    Russell E Jacobs; Fiscal Year: 2010
    ..activity with structural MRI, MEMRI, and DTI in: C57BL/6J mice to determine normal anatomy and activity; dopamine (DAT), norepinephrine (NET) and serotonin transporter (SERT) knockouts; dopamine D1 a and D2 receptor knockouts; ..
  69. Methylphenidate Use to Improve Outcomes in Geriatric Depression
    Helen Lavretsky; Fiscal Year: 2012
    ..The improvement in executive function was greater in patients who were homozygous for the dopamine transporter genotype (DAT VNTR10/10)...
  70. Affective and Genetic Correlates of Amphetamine Response
    ADAM MATTHEW LEVENTHAL; Fiscal Year: 2013
    ..This model proposes that the influence of the dopamine transporter gene (a gene that regulates a key site of action for stimulants) on amphetamine's acute reinforcing ..
  71. Bio-Behavioral Smoking Profiles in Mexican Origin Youth
    ANNA VICTORIA WILKINSON; Fiscal Year: 2012
    ..participation in physical activities, and by completing additional genotyping on DRD2, DRD4, and the dopamine transporter gene...
  72. Dopaminergic Mechanisms of Cytokine-Induced Behavioral Change
    Andrew H Miller; Fiscal Year: 2012
    ..that DA depletion is secondary to decreased synthesis and release and/or increased expression of the DA transporter (DAT) will also be explored...
  73. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..distributions in Acb spiny neurons, cholinergic interneurons, and/or dopamine terminals expressing the dopamine transporter (DAT)...
  74. Margaret E Rice; Fiscal Year: 2016
    ..and uptake dynamics with assessment of the effect of physiologically relevant (low nM) levels of insulin on dopamine transporter (DAT) expression and activity in axon terminal regions and in DA cell bodies in the ventral tegmental area (..
  75. Acquisition of a TIRF/Widefield fluorescence microscope for cell biology and neur
    Bryon D Grove; Fiscal Year: 2013
    ..and salivary gland dysfunction, 3) investigate the role of palmitoylation and phosphorylation in regulating dopamine transporter trafficking and function, and 4) investigate mechanisms underlaying cholesterol mediated neurodegeneration ..
  76. Pharmacogenetics, Emotional Reactivity & Smoking
    Paul Cinciripini; Fiscal Year: 2009
    ..We will also characterize other potential markers for neurotransmitter function (DRD4, DAT, SERT, NET) in terms of differences in both baseline emotional reactivity, and response to pharmacotherapy vs: the ..
  77. Rapid-onset Dystonia Parkinsonism (DYT12 Dystonia): Pathophysiology &Atp1a3 Mice
    Yuqing Li; Fiscal Year: 2011
    ..metabolites by HPLC, striatal dopamine receptors by radioligand binding assays and western blot analysis, dopamine transporter activity, and dopamine system function via animals'response to pharmacological administration of ..
  78. DOPAMINE TRANSPORTER IMAGING WITH FLUORINE-18 PET
    JOHN NEUMEYER; Fiscal Year: 2000
    ..Recent effects have focused on the development of PET-based radiotracers for use in studies of the dopamine transporter (DAT) abundance and pharmacology...
  79. PESTICIDES AND DOPAMINERGIC FUNCTION
    Gary Miller; Fiscal Year: 2000
    ..dopamine neurons in MPTP toxicity and idiopathic PD has been proposed to be mediated by the plasma membrane dopamine transporter (DAT), which acts as the molecular gateway for MPP+, the toxic metabolite of MPTP...
  80. Dopamine Transporter Regulation and Cocaine Responsiveness
    BRUCE MANDT; Fiscal Year: 2009
    ..level of cocaine-induced locomotor activity was significantly correlated with the level of cocaine-induced dopamine transporter (DAT) inhibition within the striatum, regardless of classification as LCRs or HCRs...
  81. METHAMPHETAMINE AND DOPAMINE TRANSPORTERS
    ANNETTE FLECKENSTEIN; Fiscal Year: 2002
    ..reported recently the novel finding that METH administration causes a rapid and reversible decrease in dopamine transporter (DAT) function which is distinct from degeneration of dopamine terminals...
  82. Development of Pharmacotherapies for Nicotine Addiction
    Frank Carroll; Fiscal Year: 2009
    ..These changes likely occur by its activity at the dopamine and norepinephrine transporters, DAT and NET, respectively...
  83. Monoamine Transporter Structure-Function Studies
    CHRISTOPHER SURRATT; Fiscal Year: 2007
    ..Pharmacological and behavioral studies indicate that the dopamine transporter protein (DAT) is the brain receptor chiefly responsible for the reward/reinforcing properties of cocaine ..
  84. CORTICOLIMBIC DEGENERATION AND TREATMENT OF DEMENTIA
    John Csernansky; Fiscal Year: 2009
    ..with cholinesterase inhibitors is now routine for patients with very mild-to-mild dementia of the Alzheimer type (DAT)...
  85. New Dopamine Transporter MRI Nanoprobes for Addiction Research
    Gordana Vitaliano; Fiscal Year: 2009
    ..PET studies consistently showed chronic reduction in dopamine transporter (DAT) density in the striatum of methamphetamine addicts...
  86. CATECHOLAMINE BIOSYNTHESIS IN THE OOCYTE
    Gary Smith; Fiscal Year: 2000
    ..cells in one of three manners; intracellular production, through membrane bound receptors or an active dopamine transporter (DAT)...
  87. Psychophysiology of Emotion in Alzheimer's Disease
    Alfred Kaszniak; Fiscal Year: 2003
    ..goal of this research is to assess emotion processing abilities of individuals with Dementia of the Alzheimer Type (DAT)...
  88. PET IMAGING AND COCAINE NEUROPHARMACOLOGY IN MONKEYS
    Leonard Howell; Fiscal Year: 2006
    ..Emphasis will be directed toward combined inhibition of the dopamine transporter (DAT) and the serotonin transporter (SERT) in the context of cocaine self-administration...
  89. DOPAMINE TRANSPORTER IMAGING IN COCAINE ABUSE
    DEAN WONG; Fiscal Year: 1999
    The long range goal of this project is to develop methods of quantifying the dopamine transporter (DAT) site in human brain to provide insight into the neuroscience of addictive behavior in cocaine abuse...