DNAI1

Summary

Gene Symbol: DNAI1
Description: dynein axonemal intermediate chain 1
Alias: CILD1, DIC1, ICS1, PCD, dynein intermediate chain 1, axonemal, dynein, axonemal, intermediate polypeptide 1, immotile cilia syndrome 1, testis tissue sperm-binding protein Li 87P
Species: human

Top Publications

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
  3. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
  4. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
  5. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
  6. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
  7. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
  8. pmc DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm
    Niki Tomas Loges
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Am J Hum Genet 83:547-58. 2008
  9. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
  10. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994

Research Grants

  1. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
  2. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2013
  3. Lawrence E Ostrowski; Fiscal Year: 2016
  4. Mihaela Teodorescu; Fiscal Year: 2015
  5. Deborah A Meyers; Fiscal Year: 2016
  6. Mario Castro; Fiscal Year: 2015
  7. Angelique Y Louie; Fiscal Year: 2014
  8. A Patient Advocate and Literacy-Based Treatment of Asthma
    Andrea J Apter; Fiscal Year: 2010
  9. PESBART: Effects of Physical Environment and Stress in Blacks in Relation to Asth
    Elliot Israel; Fiscal Year: 2013
  10. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2010

Detail Information

Publications484 found, 100 shown here

  1. ncbi EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive
    T E Milner
    Departement de Physiologie, Universite de Montreal, Quebec, Canada
    J Neurophysiol 73:2568-77. 1995
    ..wild-type) mice (+/+), as well as five lurcher (lc/+), six nervous (nr/nr), and eight Purkinje cell degeneration (pcd/pcd) mutants were implanted with chronic electromyogram (EMG) electrodes in the hamstring and quadriceps muscle ..
  2. pmc Assessment of erythrocyte shape by flow cytometry techniques
    M Piagnerelli
    Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Brussels, Belgium
    J Clin Pathol 60:549-54. 2007
    ..Several techniques are available to assess alterations in RBC rheology, especially deformability, but they are too cumbersome to be used on a large number of cells...
  3. pmc Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia
    G Pennarun
    Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
    Am J Hum Genet 65:1508-19. 1999
    ..advantage of the evolutionary conservation of genes encoding axonemal proteins, we have isolated a human sequence (DNAI1) related to IC78, a C...
  4. pmc Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)
    C Guichard
    Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
    Am J Hum Genet 68:1030-5. 2001
    ..The axonemal dynein intermediate-chain gene 1 (DNAI1), which has been demonstrated to be responsible for a case of primary ciliary dyskinesia (PCD) without situs ..
  5. ncbi Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia
    M Zariwala
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Am J Respir Cell Mol Biol 25:577-83. 2001
    ..Mutations in an intermediate chain dynein (DNAI1; IC78) have recently been described in PCD patients, with outer dynein arm (ODA) defects...
  6. pmc Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation
    Maimoona A Zariwala
    University of North Carolina at Chapel Hill 27599 7248, USA, and Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Germany
    Am J Respir Crit Care Med 174:858-66. 2006
    ..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia.
  7. doi DNAI1 mutations explain only 2% of primary ciliary dykinesia
    Mike Failly
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Respiration 76:198-204. 2008
    ..To date, 5 genes encoding 3 dynein protein arm subunits (DNAI1, DNAH5 and DNAH11), the kinase TXNDC3 and the X-linked RPGR have been found to be mutated in PCD.
  8. pmc DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm
    Niki Tomas Loges
    Department of Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany
    Am J Hum Genet 83:547-58. 2008
    ..from ciliary axonemes in respiratory cells of patients with mutations in genes encoding the ODA chains DNAH5 and DNAI1, respectively...
  9. pmc Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells
    M Shimizu
    Department of Psychiatry and Neuroscience, Kure National Hospital, Japan
    Br J Pharmacol 114:1282-8. 1995
    ..It is unlikely that this enhancement of cyclic AMP accumulation is caused by long-term antagonism of the 5-HT receptor by amitriptyline...
  10. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
    ..These data suggest that an atypical 5-HT receptor inhibits the release of neuropeptides from sensory C fibres and may act as other inhibitory neuromodulators via the opening of a common K'channel...
  11. doi Benefits and risks of adjunctive inhaled corticosteroids in chronic obstructive pulmonary disease: a meta-analysis
    Diana M Sobieraj
    University of Connecticut School of Pharmacy, Storrs, Connecticut, USA
    Clin Ther 30:1416-25. 2008
    ....
  12. pmc Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium
    A D Medhurst
    SmithKline Beecham Pharmaceuticals, The Pinnacles, Harlow, Essex
    Br J Pharmacol 110:1023-30. 1993
    ..6. The sinoatrial 5-HT4 receptor in the piglet has a pharmacological profile that correlates well with 5-HT4 receptors characterized in rat oesophagus, guinea-pig ileum and colon, mouse embryonic colliculi neurones and human atrium...
  13. pmc Mediation by 5-HT1D receptors of 5-hydroxytryptamine-induced contractions of rabbit middle and posterior cerebral arteries
    V Deckert
    Laboratoires Fournier, Daix, France
    Br J Pharmacol 112:939-45. 1994
    ..7. In conclusion, these results suggest that the contractile response to 5-HT in rabbit isolated MCA and PCA is predominantly mediated by the 5-HTID receptor subtype, although a small contribution by 5-HT3 receptors cannot be excluded...
  14. ncbi Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseases
    J L Carson
    Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill
    Ultrastruct Pathol 18:327-32. 1994
    ..cilia characterized by microtubular discontinuities and previously associated with primary ciliary dyskinesia (PCD) has been documented in other forms of chronic airways diseases, including cystic fibrosis (CF)...
  15. ncbi [Primary ciliary dyskinesia in situs inversus without bronchiectasis]
    J Gierich
    , Fachkliniken Wangen,
    Pneumologie 51:1127-32. 1997
    ..In adults suffering from Kartagener's syndrome-which is found in 50% of patients with primary ciliary dyskinesia (PCD)-bronchiectasis is still one of three typical clinical features...
  16. ncbi In-situ end labelling with bromodeoxyuridine--an advanced technique for the visualization of apoptotic cells in histological specimens
    A Aschoff
    , , Germany
    Horm Metab Res 28:311-4. 1996
    The fragmentation of nuclear DNA is considered to be a biochemical indication of programmed cell death (PCD) in various tissues...
  17. pmc Characterization of 5-HT3 receptors of N1E-115 neuroblastoma cells by use of the influx of the organic cation [14C]-guanidinium
    H Bonisch
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
    Br J Pharmacol 108:436-42. 1993
    ..7. It is concluded that [14C]-guanidinium influx measurement in N1E-115 cells is a convenient method to study properties of the cation channel of the 5-HT3 receptor. This influx is independent of the fast sodium channel...
  18. ncbi Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance
    D Promeneur
    Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
    Am J Physiol Renal Physiol 279:F1014-26. 2000
    ..Overall, these results suggest that AQP6 expression in collecting duct ICs is regulated by altered acid/alkali load or water balance. Thus AQP6 may contribute to maintenance of acid-base homeostasis and water balance...
  19. pmc Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum
    P J Johnson
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Br J Pharmacol 111:1240-4. 1994
    ....
  20. ncbi An anatomical classification--a new paradigm for management of urinary dysfunction in the female
    P E Papa Petros
    Royal Perth Hospital, Western Australia
    Int Urogynecol J Pelvic Floor Dysfunct 10:29-35. 1999
    ....
  21. ncbi Correlations between ciliary structure and ciliary function
    T Willems
    ENT Department, UZ GHB, Leuven, Belgium
    Acta Otorhinolaryngol Belg 54:299-308. 2000
    ..COR), coordinated ciliary activity and ciliary immotility were investigated based on the findings in over 700 non-PCD biopsies taken in the context of diagnostic investigations for respiratory problems...
  22. ncbi Evaluation of the utilization patterns of leukotriene modifiers in a large managed care health plan
    Paul G Lakomski
    Excellus Health Plan, Inc, 344 South Warren St, Syracuse, NY 13202, USA
    J Manag Care Pharm 10:115-21. 2004
    ....
  23. ncbi Systematic review and economic analysis of the comparative effectiveness of different inhaled corticosteroids and their usage with long-acting beta2 agonists for the treatment of chronic asthma in children under the age of 12 years
    C Main
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK
    Health Technol Assess 12:1-174, iii-iv. 2008
    ..To assess the clinical and cost-effectiveness of inhaled corticosteroids (ICS) alone and ICS used in combination with a long-acting beta2 agonist (LABA) in the treatment of chronic asthma in children aged under 12 years...
  24. pmc 5-Hydroxytryptamine (5-HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5-HT4 receptors
    T M Cocks
    Baker Medical Research Institute, Prahran, Victoria, Australia
    Br J Pharmacol 107:591-6. 1992
    ..This preparation may thus provide a robust and sensitive bioassay for future development of selective 5-HT4 receptor agonists and antagonists...
  25. pmc Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells
    Linda Mathsson
    Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
    Arthritis Res Ther 8:R64. 2006
    ..Suppression of monocytes/macrophages in RA joints or blockade of the primate-specific activating FcgammaRIIa receptor might be ways to reduce IC-induced TNF-alpha production in the joints of seropositive RA patients...
  26. pmc Programmed death in bacteria
    K Lewis
    Biotechnology Center, Tufts University, Medford, Massachusetts 02155, USA
    Microbiol Mol Biol Rev 64:503-14. 2000
    Programmed cell death (PCD) in bacteria plays an important role in developmental processes, such as lysis of the mother cell during sporulation of Bacillus subtilis and lysis of vegetative cells in fruiting body formation of Myxococcus ..
  27. ncbi Regulation of ion and water transport across the eel intestine: effects of acetylcholine and serotonin
    Y Mori
    Faculty of Integrated Arts and Sciences, Hiroshima University, Japan
    J Comp Physiol B 161:387-92. 1991
    ..Since atropine and ICS-205930 block ACh and 5-HT receptors, respectively, these results suggest that endogenous ACh and 5-HT are released by EFS...
  28. pmc Addition of long-acting beta2-agonists to inhaled steroids versus higher dose inhaled steroids in adults and children with persistent asthma
    Francine M Ducharme
    Research Centre, CHU Sainte Justine and the Department of Pediatrics, University of Montreal, 3175 Cote Sainte Catherine, Montreal, , Canada, H3T 1C5
    Cochrane Database Syst Rev 4:CD005533. 2010
    ..These trends raised concern about the safety of combination therapy in view of modest improvement in children under the age of 12 years...
  29. doi Cost-effectiveness of budesonide/formoterol for maintenance and reliever asthma therapy in Denmark--cost-effectiveness analysis based on five randomised controlled trials
    Jannie Wickstrøm
    MUUSMANN COWI, Kolding, Denmark
    Clin Respir J 3:169-80. 2009
    ....
  30. ncbi Prevention of nausea and vomiting in cisplatin-treated patients by a selective 5-hydroxytryptamine (5-HT3) receptor antagonist, ICS 205-930
    L Dogliotti
    Department of Clinical and Biological Sciences, University of Torino, Italy
    Tumori 76:595-8. 1990
    ..2%) in 2 patients. These results suggest that ICS 205-930 is an effective and well tolerated antiemetic drug in patients receiving cisplatin chemotherapy...
  31. ncbi A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma
    Jean Bousquet
    Service des Maladies Respiratoires, Hopital Arnaud de Villeneuve, Centre Hospitalier Universitaire Montpellier, France
    Clin Ther 24:1-20. 2002
    ..Although inhaled corticosteroids (ICS) are commonly used in the treatment of persistent asthma, the relationship between dose and clinical response remains unclear...
  32. ncbi Diverse effects of Purkinje cell loss on deep cerebellar and vestibular nuclei neurons in Purkinje cell degeneration mutant mice: a possible compensatory mechanism
    J Bäurle
    Department of Physiology, Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Germany
    J Comp Neurol 384:580-96. 1997
    The genetic defect in the Purkinje cell degeneration (PCD) mutant mouse completely disrupts the cerebellar corticonuclear connection through intrinsic action on the final integrating unit of the cerebellar cortex, the Purkinje cell (PC)...
  33. doi 111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1
    Bart Cornelissen
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Cancer Biother Radiopharm 24:163-73. 2009
    ....
  34. pmc Blockade of 5-HT3 receptor-mediated currents in dissociated frog sensory neurones by benzoxazine derivative, Y-25130
    T Yakushiji
    Research Laboratories, Yoshitomi Pharmaceutical Industries Ltd, Japan
    Br J Pharmacol 107:853-7. 1992
    ..6. Y-25130 (5 x 10-10 M) caused a rightward shift of the concentration-response curve for 5-HT while decreasing the maximum response.7. The results suggest that Y-25130 is a potent antagonist of the 5-HT3 receptor-channel complex...
  35. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
    ..The presence of multiple factors that bind common IFN response motifs may partly account for the complexity and diversity of IFN action as well as IFN-regulated gene expression...
  36. ncbi Effects of 5-HT(3) receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats
    Z A Rodd-Henricks
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
    Alcohol 21:73-85. 2000
    ....
  37. ncbi Inhibiting effects of serotonin and serotonin antagonists on the migration of mononuclear leucocytes
    L Bondesson
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 15:243-50. 1993
    ..No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration...
  38. ncbi Necrosis is an active and controlled form of programmed cell death
    S Ya Proskuryakov
    Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020, Russia
    Biochemistry (Mosc) 67:387-408. 2002
    In all studies on programmed cell death (PCD) and apoptosis as its most showy form, this process was considered to be a paradigmatic antithesis to necrotic cell death...
  39. ncbi Regular use of corticosteroids and low use of short-acting beta2-agonists can reduce asthma hospitalization
    Ambikaipakan Senthilselvan
    Department of Public Health Sciences, University of Alberta, 13 106B Clinical Sciences Building, Edmonton, AL, Canada, T6G 2G3
    Chest 127:1242-51. 2005
    ..The objective of this study was to determine the effect of ICS use on the association between use of ISABA and first hospitalization for asthma after controlling for several indicators of asthma severity...
  40. ncbi Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincter
    A Ouyang
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104
    Am J Physiol 254:G224-31. 1988
    ..mu-Receptor activation causes ICS contraction via a cholinergic pathway...
  41. ncbi Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia
    J Neesen
    Institute of Human Genetics, University of Gottingen, Germany
    Cytogenet Genome Res 98:38-44. 2002
    Primary ciliary dyskinesia (PCD) is a heterogeneous autosomal recessive disease that is caused by impaired ciliary and flagellar functions. About 50% of PCD patients show situs inversus, denoted as Kartagener syndrome...
  42. ncbi Is there a role for inhaled corticosteroids and macrolide therapy in bronchiectasis?
    Paul King
    Monash University, Department of Medicine, Monash Medical Centre, Melbourne, Victoria, Australia
    Drugs 67:965-74. 2007
    ..The evidence available suggests that both medications have a role in the management of bronchiectasis. More definitive trials of ICS and macrolides in bronchiectasis will clarify the likely benefit of these therapies...
  43. ncbi Removal of As(III) in a column reactor packed with iron-coated sand and manganese-coated sand
    Yoon Young Chang
    Department of Environmental Engineering, Kwangwoon University, Seoul 139 701, Republic of Korea
    J Hazard Mater 150:565-72. 2008
    ..From this work, a filtration system consisting of both MCS and ICS can potentially be used a new treatment system to simultaneously treat As(III) and As(V)...
  44. ncbi Safety of inhaled budesonide: clinical manifestations of systemic corticosteroid-related adverse effects
    Camilla Christensson
    Patient Safety, Clinical Development, AstraZeneca R and D Lund, Lund, Sweden
    Drug Saf 31:965-88. 2008
    ....
  45. ncbi Administrative claims analysis of asthma-related health care utilization for patients who received inhaled corticosteroids with either montelukast or salmeterol as combination therapy
    Felicia C Allen-Ramey
    Merck and Co, Sumneytown Pike, WP39 170, West Point, PA 19486 0004, USA
    J Manag Care Pharm 12:310-21. 2006
    ....
  46. ncbi Deregulated sequential motion of centromeres induced by antitumor agents may lead to genome instability in human peripheral blood lymphocytes
    V Bajic
    Institute for Biomedical Research, Galenika a d, Belgrade, Serbia
    J BUON 12:77-83. 2007
    ..Alteration of the sequence of centromere separation or premature centromere division (PCD) has been found to be significantly higher in populations exposed to various xenobiotics...
  47. pmc Alternative splicing and gene duplication differentially shaped the regulation of isochorismate synthase in Populus and Arabidopsis
    Yinan Yuan
    School of Forest Resources and Environmental Science, Michigan Technological University, Houghton, MI 49931, USA
    Proc Natl Acad Sci U S A 106:22020-5. 2009
    ..AtICS1 represents a divergent isoform for inducible SA synthesis during defense. Populus ICS primarily functions in phylloquinone biosynthesis, a process that can be sustained at low ICS transcript levels...
  48. ncbi ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum
    M B Hansen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
    Can J Physiol Pharmacol 72:227-32. 1994
    ..These data suggest involvement of a neuronal 5-HT4 receptor subtype and acetylcholine in 5-HT elicited SCC and chloride secretion in the pig jejunum...
  49. doi Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  50. pmc Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures
    Siamsa M Doyle
    School of Biology and Environmental Science, University College Dublin, Dublin 4, Ireland
    J Exp Bot 61:473-82. 2010
    ..ROS are known to act as regulators of programmed cell death (PCD) in plant and animal cells, so it is possible that chloroplasts have a role in regulating PCD in green tissue...
  51. pmc Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats
    Zachary A Rodd
    Department of Psychiatry, Institute of Psychiatric Research, Indiana School of Medicine, Indianapolis, USA
    Alcohol 44:245-55. 2010
    ..In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA...
  52. ncbi Regional brain distribution of noradrenaline uptake sites, and of alpha1-alpha2- and beta-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study
    C Strazielle
    Centre de Recherche en Sciences Neurologiques, Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neuroscience 94:287-304. 1999
    The mouse "Purkinje cell degeneration" (pcd) is characterized by a primary loss of Purkinje cells, as well as by retrograde and secondary partial degeneration of cerebellar granule cells and inferior olivary neurons; this neurological ..
  53. ncbi Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
    D C Grootendorst
    Dutch Asthma Centre, Davos, Switzerland
    Clin Exp Allergy 31:400-8. 2001
    ..These findings indicate that short-term, rigorous allergen avoidance can improve the long-term control of severe asthma over and above what can be achieved even by high doses of inhaled steroids...
  54. doi Inhaled corticosteroids in children: use and effects of early treatment on asthma and lung function. Prevalence of asthma and the impact of severity in early life on later asthma in childhood
    Chandra Sekhar Devulapalli
    Department of Paediatrics, Ringerike Hospital, Hønefoss, Norway
    Clin Respir J 2:247-8. 2008
    ..The role of inhaled corticosteroids (ICS) on disease progression in asthmatic children is not yet clear...
  55. ncbi Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph
    M Rafecas
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universitat Munchen, Ismaninger Str 22 81675 München, Germany
    Phys Med Biol 48:821-48. 2003
    ....
  56. ncbi Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands
    T W de Vries
    Department of Pediatrics, Medical Centre Leeuwarden, P O Box 888, 8901 BR Leeuwarden, The Netherlands
    Eur J Clin Pharmacol 62:343-6. 2006
    ..Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands...
  57. doi Association between previous health care use and initiation of inhaled corticosteroid and long-acting beta2-adrenergic agonist combination therapy among US patients with asthma
    Christopher M Blanchette
    Division of Clinical and Outcomes Research, Lovelace Respiratory Research Institute, Kannapolis, North Carolina 287081, USA
    Clin Ther 31:2574-83. 2009
    ....
  58. ncbi Altered mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas
    W Li
    Department of Ophthalmology, Allegheny University, Philadelphia, PA 19102, USA
    Cell Mol Biol (Noisy-le-grand) 45:59-66. 1999
    Because programmed cell death (PCD) is an important mode of pericyte dropout in human diabetic retinopathy, whether increased oxidative stress in cells with diminished antioxidant defenses plays a causative role in the PCD process in ..
  59. ncbi A comparison of the risk of hospitalizations due to chronicobstructive pulmonary disease in medicaid patients with various medication regimens, including ipratropium, inhaled corticosteroids, salmeterol, or their combination
    Karen L Rascati
    College of Pharmacy, University of Texas at Austin, Austin, Texas 78712 0127, USA
    Clin Ther 27:346-54. 2005
    ..The aim of this study was to compare the risk of hospitalizations related to chronic obstructive pulmonary disease (COPD) among Medicaid patients prescribed various medication regimens...
  60. ncbi Patterns and determinants of compliance with inhaled steroids in adults with asthma
    Yves Lacasse
    Centre de Recherche, Hopital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l Universite Laval, Ste Foy, Qubec, Canada
    Can Respir J 12:211-7. 2005
    ..Patient compliance with inhaled corticosteroids (ICS) in asthma is considered to be suboptimal...
  61. pmc Living with primary ciliary dyskinesia: a prospective qualitative study of knowledge sharing, symptom concealment, embarrassment, mistrust, and stigma
    Simon Whalley
    Department of Psychology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Pulm Med 6:25. 2006
    Primary ciliary dyskinesia (PCD) is a chronic respiratory disease for which there is little psycho-social research and no qualitative studies of individuals living with the condition...
  62. ncbi Effects on resource utilization of adding salmeterol in combination or separately to inhaled corticosteroids
    James Chan
    Pharmacy Outcomes Research Group, Kaiser Permanente Medical Care Program, 1800 Harrison, 13th Fl, Oakland, CA 94612, USA
    J Manag Care Pharm 13:21-7. 2007
    ....
  63. ncbi Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma
    R Buhl
    Pulmonary Department, Mainz University Hospital, Mainz, Germany
    Curr Med Res Opin 23:1867-78. 2007
    ..This option is well tolerated and offers greater reductions in asthma exacerbations together with similar improvements in daily symptom control, at a lower overall steroid load, compared with fixed-dose ICS/LABA plus SABA...
  64. ncbi Sonographically guided percutaneous catheter drainage versus needle aspiration in the management of pyogenic liver abscess
    Enver Zerem
    Interventional Ultrasonography Department, University Clinical Center, Trnovac bb, Tuzla, Bosnia and Herzegovina
    AJR Am J Roentgenol 189:W138-42. 2007
    The purpose of this study was to determine the effectiveness of percutaneous catheter drainage (PCD) and to compare PCD with percutaneous needle aspiration in the management of liver abscess.
  65. ncbi [Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70]
    Yu Zhang
    Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:354-7. 2008
    ..To investigate the immunocontraceptive effect of Lagurus lagurus zona pellucida 3 gene (LZP3) fused by Mycobacterium tuberculosis HSP70 and C-terminal of HSP70...
  66. pmc Inhaled corticosteroids in patients with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    JAMA 300:2407-16. 2008
    ..Recent studies of inhaled corticosteroid (ICS) therapy for managing stable chronic obstructive pulmonary disease (COPD) have yielded conflicting results regarding survival and risk of adverse events...
  67. doi [Primary ciliary dyskinesia (Pcd) in Austria]
    Irena Lesic
    Medizinische Universität Wien, Universitätsklinik für Kinder und Jugendheilkunde, Wien, Austria
    Wien Klin Wochenschr 121:616-22. 2009
    Primary ciliary dyskinesia (PCD) is a rare hereditary recessive disease with symptoms of recurrent pneumonia, chronic bronchitis, bronchiectasis, and chronic sinusitis...
  68. ncbi Von Willebrand factor, fibrinogen and other risk factors of thrombosis in patients with a history of cerebrovascular ischemic stroke and their children
    M Jastrzebska
    Clinical Biochemistry and Laboratory Diagnostics, Regional Center for Atherosclerosis Research, Pomeranian Academy of Medicine, Al Powstaców Wlkp 72, PL 70 111 Szczecin, Poland
    Nutr Metab Cardiovasc Dis 12:132-40. 2002
    ..We investigated whether the vWF and Fb levels in patients with ischemic cerebrovascular stroke (ICS) correlate with those in their children...
  69. ncbi Apoptosis: correlation of cytological changes with biochemical markers in hormone-dependent tissues
    A Aschoff
    Department of Anatomy II, Friedrich-Schiller-University, Jena, Germany
    Horm Metab Res 29:535-43. 1997
    The term apoptosis, also known as programmed cell death (PCD), is used in contrast to necrotic cell death and occurs in various tissues in many different circumstances...
  70. ncbi Embryonic cerebellar graft development during acute phase of gliosis in the cerebellum of pcd mutant mice
    A C Chang
    Institute of Neuroscience, National Yang Ming Medical College, Taipei, Taiwan, R O C
    Chin J Physiol 36:141-9. 1993
    Anatomical and biochemical changes in cerebellum after the onset of pcd gene defects have revealed in addition to Purkinje cell degeneration, the occurrence of secondary degenerative events in granule neurons, neurons of the inferior ..
  71. ncbi [Inhalation corticosteroids and the growth of asthmatic children]
    P L Brand
    Isala Klinieken, Zwolle
    Ned Tijdschr Geneeskd 143:2041-5. 1999
    ..When growth is reduced by > 0.25 standard deviation score within 1 year, the use of ICS needs to be reconsidered. This decision can best be made by a paediatrician or after consulting one...
  72. ncbi The anti-death league: associative control of apoptosis in developing retinal tissue
    R Linden
    Instituto de Biofisica da UFRJ, Cidade Universitaria, Centro de Ciencias da Saude, Rio de Janeiro, Brazil
    Brain Res Brain Res Rev 32:146-58. 2000
    Apoptosis, the major form of programmed cell death (PCD), is executed through a proteolytic cascade that can be differentially engaged by various extracellular signals...
  73. ncbi Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1
    Angeles Fernandez-Gonzalez
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 295:1904-6. 2002
    The classical recessive mouse mutant, Purkinje cell degeneration (pcd), exhibits adult-onset degeneration of cerebellar Purkinje neurons, retinal photoreceptors, olfactory bulb mitral neurons, and selected thalamic neurons, and has ..
  74. ncbi Are inhaled corticosteroids effective for acute exacerbations of asthma in children?
    Leslie Hendeles
    Department of Pharmacy Practice, College of Pharmacy, The University of Florida, Gainesville 32610, USA
    J Pediatr 142:S26-32; discussion S32-3. 2003
    ..In more severe exacerbations, oral corticosteroids are significantly more effective in preventing hospitalizations and improving lung function. We conclude that ICS should not be used routinely to treat acute exacerbations...
  75. ncbi Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion
    Woong Sun
    Department of Neurobiology and Anatomy, and Neuroscience Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 23:7298-310. 2003
    The removal of excess neurons by programmed cell death (PCD) is believed to be critical for the proper development and function of the nervous system...
  76. pmc C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment
    Tracy Stokol
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 200:835-46. 2004
    ..These studies suggest a regulatory mechanism of IC deposition and leukocyte trafficking in IC-mediated inflammation requiring C1q and FcgammaRs in sequential, noninteracting roles...
  77. pmc Mucociliary and long-term particle clearance in airways of patients with immotile cilia
    Winfried Möller
    Institute for Inhalation Biology, Clinical Research Group Inflammatory Lung Diseases, GSF National Research Centre for Environment and Health, Robert Koch Allee 29, D 82131 Gauting Munich, Germany
    Respir Res 7:10. 2006
    ..2 microm aerodynamic diameter were inhaled by seven patients with primary ciliary dyskinesia (PCD) using the shallow bolus technique, and compared to 13 healthy non-smokers (NS) from a previous study...
  78. ncbi Relationship between house dust mite (HDM) allergen exposure level and inhaled corticosteroid dosage in HDM-sensitive asthma patients on a self management program
    Marjolein P de Vries
    Department of General Practice, Research Institute Caphri, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Prim Care Respir J 15:110-5. 2006
    ..To assess whether exposure to house dust mite (HDM) allergens hampers a tapering off of inhaled corticosteroid (ICS) dosage in HDM-sensitive asthma patients...
  79. ncbi Publish or be damned? The fate of abstracts presented at the International Continence Society Meeting 2003
    Rufus Cartwright
    Department of Urogynaecology, King s College Hospital, Denmark Hill, London, England, UK
    Neurourol Urodyn 26:154-7. 2007
    ..It analyzed the rate and timing of full publication, the factors predicting successful publication, the consistency of reporting between presented abstracts and published abstracts, and the barriers to publication...
  80. ncbi Carrier status for 3 most frequent CFTR mutations in Polish PCD/KS patients: lack of association with the primary ciliary dyskinesia phenotype
    Urszula Skrzypczak
    Department of Molecular and Clinical Genetics, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland
    J Appl Genet 48:85-8. 2007
    We screened a large group of primary ciliary dyskinesia/Kartagener syndrome (PCD/KS) patients and their siblings (148 patients from 126 unrelated families) for the presence of the CFTR mutations that are most frequently found in the ..
  81. ncbi Is airway inflammation in chronic obstructive pulmonary disease (COPD) a risk factor for cardiovascular events?
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Liverpool, UK
    COPD 3:233-42. 2006
    ..A large multicenter prospective randomized trial (Towards a Revolution in COPD Health [TORCH]) is now ongoing and will examine the effect of fluticasone propionate in combination with salmeterol on all-cause mortality...
  82. doi Identification of homemade inorganic explosives by ion chromatographic analysis of post-blast residues
    Cameron Johns
    Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania 7001, Australia
    J Chromatogr A 1182:205-14. 2008
    ..The results obtained were also confirmed by parallel analysis of the same samples by capillary electrophoresis (CE) with excellent agreement being obtained...
  83. doi Interleukin-15 enhance DNA vaccine elicited mucosal and systemic immunity against foot and mouth disease virus
    Xiao Wang
    State Key Laboratory for Agro Biotechnology, College of Biological Science, China Agricultural University, Beijing 100094, China
    Vaccine 26:5135-44. 2008
    ..chitosan as a delivery vehicle, we investigated whether co-administration intranasally of the FMDV DNA vaccine, pcD-VP1 and a construct expressing IL-15 as the molecular adjuvant can enhance mucosal and systemic immune responses in ..
  84. doi Relationship between inhaled corticosteroid therapy and rate of lung function decline in children with cystic fibrosis
    Clement L Ren
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    J Pediatr 153:746-51. 2008
    ....
  85. pmc When is a malaria immune complex not an immune complex?
    R J Pleass
    Institute of Genetics, Queen s Medical Centre, Nottingham, UK
    Parasite Immunol 31:61-3. 2009
    ..However, researchers should be aware of potential pitfalls to current assays aimed at measuring plasma ICs and correlating these to deposition in tissues...
  86. doi Circulating non-immune IgG complexes in health and disease
    Roald Nezlin
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Immunol Lett 122:141-4. 2009
    ..Therefore, in order to identify potential biomarkers, not only proteins that are free in the liquid phase of serum but also proteins associated with abundant proteins such as IgG must be investigated...
  87. pmc Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    Keith Syson Chan
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94304 5542, USA
    Proc Natl Acad Sci U S A 106:14016-21. 2009
    ..Blockade of CD47 by a mAb resulted in macrophage engulfment of bladder cancer cells in vitro. In summary, we have identified a T-IC subpopulation with potential prognostic and therapeutic value for invasive bladder cancer...
  88. doi Susceptibility of Phelipanche and Orobanche species to AAL-toxin
    Axel de Zélicourt
    Laboratoire de Biologie et Pathologie Végétales, EA 1157, IFR 149 QUASAV, Universite de Nantes, 44322 Nantes Cedex 3, France
    Planta 230:1047-55. 2009
    ..These long chain bases (LCBs) are determinant in the occurrence of programmed cell death (PCD) in susceptible plants...
  89. pmc No electron left behind: a rule-based expert system to predict chemical reactions and reaction mechanisms
    Jonathan H Chen
    Institute for Genomics and Bioinformatics and Department of Computer Science, School of Information and Computer Sciences, University of California, Irvine, Irvine, California 92697 3435, USA
    J Chem Inf Model 49:2034-43. 2009
    ..Select applications are available via http://cdb.ics.uci.edu...
  90. doi Programmed cell death in unicellular parasites: a prerequisite for sustained infection?
    Ger van Zandbergen
    University of Ulm, Germany
    Trends Parasitol 26:477-83. 2010
    The detection of markers typical for metazoan programmed cell death (PCD) in diverse protozoan parasites raised a debate about the evolution of PCD processes and its impact on the biology of single-celled parasites...
  91. doi Cyclophilin D links programmed cell death and organismal aging in Podospora anserina
    Diana Brust
    Johann Wolfgang Goethe University, Institute of Molecular Biosciences, Frankfurt, Germany
    Aging Cell 9:761-75. 2010
    ..Our data provide a mechanistic link between programmed cell death (PCD) and organismal aging and bear implications for the potential use of CSA to intervene into biologic aging.
  92. doi Twenty-six-week efficacy and safety study of mometasone furoate/formoterol 200/10 microg combination treatment in patients with persistent asthma previously receiving medium-dose inhaled corticosteroids
    Robert A Nathan
    Asthma and allergy Associates and Research Center, Colorado Springs, Colorado 80907, USA
    Allergy Asthma Proc 31:269-79. 2010
    ..Treatment with MF/F 200/10 microg was effective in reducing the risk of asthma deteriorations. MF/F was safe and provided rapid and sustained bronchodilation in patients with asthma...
  93. doi Intercellular space volume is mainly increased in the basal layer of esophageal squamous epithelium in patients with GERD
    Helmut Neumann
    Department of Medicine I, University of Erlangen Nuremberg, Ulmenweg 18, 91054, Erlangen, Germany
    Dig Dis Sci 56:1404-11. 2011
    ..Therefore, we aimed to assess the volumetric amount of the ICS in all layers of SE in patients with GERD...
  94. doi Impact of socioeconomic status on the use of inhaled corticosteroids in young adult asthmatics
    Jesper Rømhild Davidsen
    University of Southern Denmark, Faculty of Health Sciences, Institute of Public Health, Research Unit of General Practice, J B Winsløws Vej 9A, DK 5000 Odense C, Denmark
    Respir Med 105:683-90. 2011
    ....
  95. doi The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
    ..Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs...
  96. doi A snapshot of general practitioner attitudes, levels of confidence and self-reported paediatric asthma management practice
    Jessica K Roydhouse
    Woolcock Institute of Medical Research, Glebe, NSW 2037, Australia
    Aust J Prim Health 17:288-93. 2011
    ..These findings indicate gaps between GP attitudes and behaviours and highlights opportunities for interventions to improve paediatric asthma management...
  97. doi Heparin inhibits the interaction of DNA topoisomerase I/anti-topoisomerase I immune complexes with heparan sulfate on dermal fibroblasts
    Julie Arcand
    Notre Dame Hospital, Centre Hospitalier de l Universite de Montreal, and Université de Montréal, Montreal, Quebec, Canada
    Arthritis Rheum 64:1632-41. 2012
    ..This study aimed to characterize the molecular interactions of topo I with fibroblast surfaces in order to elucidate the pathogenic role of topo I/anti-topo I immune complexes (ICs) in SSc...
  98. doi Calmodulin-binding protein CBP60g is a positive regulator of both disease resistance and drought tolerance in Arabidopsis
    Dongli Wan
    College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010018, People s Republic of China
    Plant Cell Rep 31:1269-81. 2012
    ..We also found that treatment with ABA and drought stress leads to a higher expression level of the ICS1 gene, which encodes isochorismate synthase, in the CBP60g overexpression lines than in the wild-type control plants...
  99. pmc Optimization and qualification of an 8-color intracellular cytokine staining assay for quantifying T cell responses in rhesus macaques for pre-clinical vaccine studies
    Mitzi M Donaldson
    Nonhuman Primate Immunogenicity Core, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA
    J Immunol Methods 386:10-21. 2012
    ....
  100. doi Risk of asthma exacerbation, asthma-related health care utilization and costs, and adherence to controller therapy in patients with asthma receiving fluticasone propionate/salmeterol inhalation powder 100 μg/50 μg versus mometasone furoate inhalation powd
    May Hagiwara
    Policy Analysis Inc, Brookline, MA 02445, USA
    J Asthma 50:287-95. 2013
    ..This study compares asthma-related outcomes and health care utilization and costs in clinical practice in patients starting fluticasone propionate 100 μg and salmeterol 50 μg via Diskus (FSC) or mometasone furoate (MF)...
  101. doi Discordance between asthma control clinical, physiological and inflammatory parameters in mild asthma
    Marie Eve Boulay
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, QC, Canada
    Respir Med 107:511-8. 2013
    ..This study compared the prevalence of discrepancies between these 3 control parameters in mild asthmatic subjects not taking ICS...

Research Grants79

  1. Extra-Fine Inhaled Corticosteroid Effect on Distal Lung Disease in Asthma
    Michelle Zeidler; Fiscal Year: 2007
    ..This study will determine the potential to modify distal airways inflammation which may ultimately improve asthma control. [unreadable] [unreadable]..
  2. PHARMACOGENOMICS OF INHALED CORTICOSTEROID RESPONSIVENESS IN PATIENTS WITH ASTHMA
    Keoki Williams; Fiscal Year: 2013
    ..Knowledge gained from this study may help clinicians select asthma treatments most likely to work for their patients, as well as provide insight for future asthma therapeutics. ..
  3. Lawrence E Ostrowski; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Primary ciliary dyskinesia (PCD) is an autosomal recessive disease caused by mutations that disrupt ciliary function and result in defective mucociliary clearance (MCC)...
  4. Mihaela Teodorescu; Fiscal Year: 2015
    ..abstract_text> ..
  5. Deborah A Meyers; Fiscal Year: 2016
    ....
  6. Mario Castro; Fiscal Year: 2015
    ..In summary, these studies address current gaps in the evidence base for asthma treatment decision making as well as explore novel therapeutic strategies in patients in whom inadequate asthma control remains commonplace. ..
  7. Angelique Y Louie; Fiscal Year: 2014
    ..The ability to image the cells in vivo can aid in design of therapy as well as in monitoring the effectiveness of therapy. ..
  8. A Patient Advocate and Literacy-Based Treatment of Asthma
    Andrea J Apter; Fiscal Year: 2010
    ..It is compared for efficacy and cost-effectiveness with asthma education. We fulfill ARRA goals by creating or retaining partial or complete funding for 16 area jobs. ..
  9. PESBART: Effects of Physical Environment and Stress in Blacks in Relation to Asth
    Elliot Israel; Fiscal Year: 2013
    ....
  10. CAMP Continuation Study/Phase 3
    Robert Strunk; Fiscal Year: 2010
    ..End of Abstract.) ..
  11. CAMP Continuation Study/Phase 3
    Hartmut Grasemann; Fiscal Year: 2010
    ..End of Abstract.) ..
  12. JOE WESLEY RAMSDELL; Fiscal Year: 2014
    ....
  13. Michael E Wechsler; Fiscal Year: 2015
    ..The National Jewish site will contribute collaborative experience, leadership skills and commitment for recruitment of adults and children to participate in AsthmaNet trials. ..
  14. Joan Reibman; Fiscal Year: 2015
    ....
  15. Jen hwa Chu; Fiscal Year: 2014
    ..We believe the proposed method will give more insight to the underlying biology of differential drug response and lead to development of more effective treatment plan for patients. ..
  16. An Asthma Adherence Telehealth System to Improve Asthma Management
    ANDREW GEORGE WEINSTEIN; Fiscal Year: 2013
    ..We will market to disease management companies and entities with financial risk such as ACOs, patient-centered medical homes, at-risk provider networks, insurers and the VA. ..
  17. JEFFREY AVINS GLASSBERG; Fiscal Year: 2016
    ....
  18. Real-world patient responsiveness &safety of long-acting beta agonists in asthma
    Pingsheng Wu; Fiscal Year: 2013
    ..Such knowledge will have widespread public health impact in asthma disease management. ..
  19. Loretta G Que; Fiscal Year: 2016
    ..Completion of these specific aims will critically advance our understanding of the potential impact and limitations of GSNO- based therapies as acute and chronic treatments for asthma. ! ..
  20. BELT: Blacks &Exacerbations on LABA vs. Tiotropium
    Elliot Israel; Fiscal Year: 2011
    ....
  21. Sally E Wenzel; Fiscal Year: 2015
    ..Finally, the severe asthma protocol will focus on the mast cell, specifically prostaglandin D2 and its interaction with CRTH2. We believe these studies address unmet needs in asthma and will improve its therapy. ..
  22. Wanda Phipatanakul; Fiscal Year: 2015
    ....
  23. Daniel J Tschumperlin; Fiscal Year: 2014
    ..abstract_text> ..
  24. Maria T Britto; Fiscal Year: 2014
    ..Through this research, we will gather data on feasibility, usability and efficacy of the intervention that will ead to a future R01 application to examine the intervention's efficacy in a fully powered randomized trial. ..
  25. PHARMACOGENOMICS OF INHALED CORTICOSTEROIDS TO REDUCE COPD EXACERBATIONS
    Craig P Hersh; Fiscal Year: 2013
    ..The clinical, imaging, and genetic predictors of ICS response will be combined to construct a predictive model, making an important step towards a personalized genomics approach to COPD symptom management. ..
  26. Individualized Interventions to Improve Asthma Adherence
    Andrea Apter; Fiscal Year: 2009
    ..We will estimate the incremental cost-effectiveness of PS. ..
  27. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  28. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ....
  29. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..The caspase-independent programmed cell death (PCD) is due in large part to the activation/translocation of apoptosis-inducing factor (AIF)...
  30. Non-viral gene therapy for sickle cell anemia
    CLIFFORD JOHN STEER; Fiscal Year: 2012
    ..The ultimate goal of this research project is to develop and evaluate in patients an innovative gene therapy approach that has the potential to treat and correct SCA. ..
  31. Transplantation tolerance and immune function following mTOR inhibition.
    Jonathan D Powell; Fiscal Year: 2013
    ..It is hoped that the results of this study will allow safer application of this curative therapy to a greater number of patients and aid in improving tolerogenic therapy for autoimmunity and solid organ transplantation as well. ..
  32. Edward D Chan; Fiscal Year: 2015
    ..reduces viability of intracellular MTB by inducing macrophages to undergo various types of programmed cell death (PCD), including caspase-3-dependent and caspase-independent apoptosis as well as pyroptosis, a unique form of ..
  33. Progesterone &Estrogen Differentially Regulate DC Function in Lupus Autoimmunity
    Grant Hughes; Fiscal Year: 2012
    ..Moreover, they will identify novel therapeutic approaches for treatment and prevention of disease development in SLE patients. ..
  34. Pilot Studies of Gene Therapy for Primary Ciliary Dyskinesia
    Lawrence E Ostrowski; Fiscal Year: 2010
    ..application is focused on developing gene therapy as a treatment for the rare disease Primary Ciliary Dyskinesia (PCD)...
  35. Programmed Cell Death and Disease Resistance in Arabidopsis
    Roger W Innes; Fiscal Year: 2013
    ..provided by applicant): This project focuses on the molecular mechanisms that mediate programmed cell death (PCD) in plants, specifically in response to pathogen infection...
  36. Michael R Knowles; Fiscal Year: 2016
    ..the past 4 years, this Consortium has made great progress in studies of variant CF, Primary Ciliary Dyskinesia (PCD), and pseudohypoaldosteronism...
  37. ROLE OF Nna1 IN RETINAL AND CEREBELLAR DEGENERATION
    Albert R La Spada; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving the retina and cerebellum, with a phenotype of ataxia and blindness...
  38. Tanya N Mayadas; Fiscal Year: 2016
    ..abstract_text> ..
  39. Identification and Characterization of New Genes Required for Cilia Motility
    Jennifer R Panizzi; Fiscal Year: 2010
    ..goal of this proposed research is to further elucidate the mechanisms underlying primary ciliary dyskinesia (PCD)...
  40. CYTOMEGALOVIRUS DNA REPLICATION AND INVERSION
    Edward S Mocarski; Fiscal Year: 2013
    ..Programmed cell death (PCD), sensor-triggered interferon activation, and signaling cascades are all affected starting at early times during ..
  41. Ebenezer N Yamoah; Fiscal Year: 2014
    ..abstract_text> ..
  42. Fc receptor targeted therapy for immune hemolytic anemia
    Periasamy Selvaraj; Fiscal Year: 2009
    ..Project Description Page 6 ..
  43. Douglas T Golenbock; Fiscal Year: 2015
    ..Gallego spends in South America will increase, with the ultimate goal of exporting cutting edge technology and expertise to the scientific community in Colombia. ..
  44. Jun Chen; Fiscal Year: 2015
    ..Our results support the current concept that mitochondrial-dependent programmed cell death (PCD) and necrosis-triggered neuroinflammation via microglial overactivation are two important mechanisms that ..
  45. Igor J Koralnik; Fiscal Year: 2016
    ..The knowledge we will gain from these studies will greatly expand our understanding of JCV pathogenesis and will have a direct impact on patient care. ..
  46. N Louise Glass; Fiscal Year: 2014
    ..Nonself recognition leads to a type of fungal programmed cell death (PCD) termed heterokaryon incompatibility (HI)...
  47. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    ..The successful completion of the Aims of this application will contribute to new strategies to treat disorders of acidification in the kidney and in the urogenital tract. ..
  48. Tanya L Kowalczyk Mullins; Fiscal Year: 2016
    ....
  49. The molecular mechanisms by which mammalian Fused regulates motile cilia function
    Pao Tien Chuang; Fiscal Year: 2012
    ..Dysfunction of motile cilia and flagella underlies the human syndrome of primary ciliary dyskinesia (PCD)...
  50. Xinnian Dong; Fiscal Year: 2016
    ..broad-spectrum resistance that can be induced by a local pathogen challenge that results in programmed cell death (PCD) or by exogenous application of SA. SA signaling requires the function of the transcription cofactor NPR1 protein...
  51. Claire M Doerschuk; Fiscal Year: 2016
    ..Microbiomics pursues the airway microbiome in COPD, CF, PCD, environmental lung disease and pneumonia...
  52. Jan Novak; Fiscal Year: 2016
    ..Relevance: The results will shed light on the pathogenesis of IgAN and identify therapeutic targets for disease-specific treatment of IgAN as well as potential response/prognostic biomarkers. ..
  53. George J Schwartz; Fiscal Year: 2014
    ..The results of these studies are likely to change our understanding of acid-base physiology and elicit new mechanisms for heretofore unexplained causes of distal renal tubular acidosis. ..
  54. Microparticles as a Source of Nuclear Antigens in Systemic Lupus Erythematosus
    David Stephen Pisetsky; Fiscal Year: 2010
    ..Understanding the role of microparticles in the immune complex disease will provide information to allow the development of new treatments as well as markers to assess the course of SLE and its renal and vascular complications. ..
  55. Dennis Brown; Fiscal Year: 2016
    ..abstract_text> ..
  56. Mechanisms of Associative Learning in Aging: Mouse Models
    Diana S Woodruff Pak; Fiscal Year: 2010
    ..explores neuron and glia number and learning in young homozygous and aging heterozygous Purkinje cell degeneration (pcd) mutant mice. Aims 3 and 4 examine functional aging of neurons in hippocampal and cerebellar slices, respectively...
  57. ??PK mediated melanoma stem cell oncolysis through non-redundant programmed cell
    ARIC G COLUNGA; Fiscal Year: 2011
    ..efforts seek to improve replication but virotherapy strategies based on the induction of programmed cell death (PCD) are not available...
  58. Jeremy B Sokolove; Fiscal Year: 2015
    ....
  59. STRUCTURAL BIOLOGY OF DIOXYGENASES
    Douglas Ohlendorf; Fiscal Year: 2003
    ..The principal target of this project has been protocatechuate 3,4-dioxygenase (3,4-PCD; Fe+3 cofactor, cleaves aromatic rings between hydroxyls) which has been used as a model system...
  60. Molecular Basis of Pathogen-Induced Cell Death in Plants
    JEAN GREENBERG; Fiscal Year: 2009
    ..approaches to examine a major signaling pathway that controls innate immunity and programmed cell death (PCD). The control of plant defenses has many parallels with human innate immunity...
  61. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2001
    ..studies, we find that hyperglycemia leads to impaired rat DRG sensory neuronal growth and programmed cell death (PCD). In both paradigms, IGF-I is neuroprotective...
  62. PHOTOCHEMICAL DECONTAMINATION OF PLATELET CONCENTRATES
    Laurence Corash; Fiscal Year: 1993
    ..A photochemical decontamination(PCD) technique has been developed utilizing 8-methoxypsoralen (8-MOP) and long wavelength ultraviolet irradiation (UVA) ..
  63. IDENTIFICATION OF BIOCHEMICAL ABNORMALITIES IN PCD CILIA
    LAWRENCE OSTROWSKI; Fiscal Year: 2002
    Primary ciliary dyskinesia (PCD) is an inherited disease which is characterized by various ultrastructural abnormalities in the cilia lining the respiratory tract...
  64. Conditional Deletion of Dnaic1 as a Model of Primary Ciliary Dyskinesia
    LAWRENCE OSTROWSKI; Fiscal Year: 2007
    ..Recent work has identified mutations in two ciliary proteins, DNAI1 and DNAH5, which together account for the disease in about 20% of the patients analyzed...
  65. Apoptosis Execution Pathways in Dopaminergic Cell Death
    Jun Chen; Fiscal Year: 2007
    ..the etiology remains unknown, there is considerable evidence that supports the view that programmed cell death (PCD) contributes, at least in part, to the degeneration of dopaminergic neurons in PD...