Gene Symbol: DNAH8
Description: dynein axonemal heavy chain 8
Alias: ATPase, hdhc9, dynein heavy chain 8, axonemal, axonemal beta dynein heavy chain 8, ciliary dynein heavy chain 8, dynein, axonemal, heavy polypeptide 8
Species: human

Top Publications

  1. pmc Regulation of vascular and gastric smooth muscle contractility by pervanadate
    A Laniyonu
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB, Canada
    Br J Pharmacol 113:403-10. 1994
  2. pmc Effects of high calcium diet on arterial smooth muscle function and electrolyte balance in mineralocorticoid-salt hypertensive rats
    P Arvola
    Department of Biomedical Sciences, University of Tampere, Finland
    Br J Pharmacol 108:948-58. 1993
  3. pmc Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells
    J Pfeilschifter
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 110:847-53. 1993
  4. ncbi Inhibitors of Na-K-ATPase in human urine: effects of ouabain-like factors and of vanadium-diascorbate on calcium mobilization in rat vascular smooth muscle cells: comparison with the effects of ouabain, angiotensin II, and arginine-vasopressin
    H Meyer-Lehnert
    Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 13:364-9. 2000
  5. ncbi Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats
    K Higashiura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 12:596-602. 1999
  6. ncbi Endogenous natriuretic and ouabain-like factors. Their roles in body fluid volume and blood pressure regulation
    H J Kramer
    Department of Medicine, University of Bonn, FRG
    Am J Hypertens 4:81-9. 1991
  7. pmc Role of the LXCXE binding site in Rb function
    A Dahiya
    Division of Molecular Oncology, Departments of Medicine and Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 20:6799-805. 2000
  8. pmc Acid secretion and the H,K ATPase of stomach
    C Prinz
    University of California at Los Angeles
    Yale J Biol Med 65:577-96. 1992
  9. pmc Gastric acid secretion: activation and inhibition
    G Sachs
    University of California Los Angeles, USA
    Yale J Biol Med 67:81-95. 1994
  10. pmc Acid, protons and Helicobacter pylori
    G Sachs
    Department of Medicine and Physiology, University of California, USA
    Yale J Biol Med 69:301-16. 1996

Research Grants

  1. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2012
  2. Silvia N Moreno; Fiscal Year: 2016
  3. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
  4. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
  5. Seth L Robia; Fiscal Year: 2014
  6. Christos S Katsanos; Fiscal Year: 2015
  7. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2013
  8. Roberto Docampo; Fiscal Year: 2016
  9. H+-ATPase B-subunit Dysfunction and Calcium Nephrolithiasis
    Orson W Moe; Fiscal Year: 2010
  10. Na,K-ATPase as an Integrator of the Calcium-signaling Machinery
    Zijian Xie; Fiscal Year: 2010

Detail Information

Publications2209 found, 100 shown here

  1. pmc Regulation of vascular and gastric smooth muscle contractility by pervanadate
    A Laniyonu
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB, Canada
    Br J Pharmacol 113:403-10. 1994
    ..independent of extracellular sodium, would appear not to be due either to Na+/Ca2" exchange, promoted by Na+/K+-ATPase inhibition or to the inhibition of Ca2+-ATPase and might be best explained by the ability of PV, via tyrosine ..
  2. pmc Effects of high calcium diet on arterial smooth muscle function and electrolyte balance in mineralocorticoid-salt hypertensive rats
    P Arvola
    Department of Biomedical Sciences, University of Tampere, Finland
    Br J Pharmacol 108:948-58. 1993
    ..5. The functions of arterial smooth muscle Na+, Ca2+ exchange and Ca(2+)-ATPase were evaluated by the aortic contractions elicited by low Na+ medium, and the subsequent relaxation responses ..
  3. pmc Extracellular ATP and UTP activation of phospholipase D is mediated by protein kinase C-epsilon in rat renal mesangial cells
    J Pfeilschifter
    Department of Pharmacology, University of Basel, Switzerland
    Br J Pharmacol 110:847-53. 1993
    ..5. Elevation of cytosolic free Ca2+ by the calcium ionophore A23187 (1 microM) or the Ca(2+)-ATPase inhibitor, thapsigargin (200 nM) slightly increased phosphatidylethanol formation...
  4. ncbi Inhibitors of Na-K-ATPase in human urine: effects of ouabain-like factors and of vanadium-diascorbate on calcium mobilization in rat vascular smooth muscle cells: comparison with the effects of ouabain, angiotensin II, and arginine-vasopressin
    H Meyer-Lehnert
    Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 13:364-9. 2000
    ..previous studies we described the presence of two low molecular (Mr approximately equals 400) inhibitors of Na-K-ATPase in human urine, ie, a more polar OLF-1 and a more apolar OLF-2...
  5. ncbi Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats
    K Higashiura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 12:596-602. 1999
    ..the end of the glucose clamp, the soleus muscle was dissected out for determination of muscle fiber composition by ATPase methods...
  6. ncbi Endogenous natriuretic and ouabain-like factors. Their roles in body fluid volume and blood pressure regulation
    H J Kramer
    Department of Medicine, University of Bonn, FRG
    Am J Hypertens 4:81-9. 1991
    ..fatty acids, which in vitro exhibit inhibition of transepithelial sodium transport, direct inhibition of the Na-K-ATPase enzyme, displacement of 3H-ouabain from its membrane receptor, and crossreaction with a digoxin antibody...
  7. pmc Role of the LXCXE binding site in Rb function
    A Dahiya
    Division of Molecular Oncology, Departments of Medicine and Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell Biol 20:6799-805. 2000
    ..Mutation of the LXCXE binding site does not inhibit binding of the BRG1 ATPase component of the SWI/SNF nucleosome remodeling complex, which has been shown previously to be important for Rb ..
  8. pmc Acid secretion and the H,K ATPase of stomach
    C Prinz
    University of California at Los Angeles
    Yale J Biol Med 65:577-96. 1992
    ..These independent pathways converge to activate the gastric acid pump, the H+,K+ ATPase. Activation is a function of the association of the ATPase with a potassium chloride transport pathway that occurs ..
  9. pmc Gastric acid secretion: activation and inhibition
    G Sachs
    University of California Los Angeles, USA
    Yale J Biol Med 67:81-95. 1994
    ..H2-receptor mediated sequence of events in the parietal cell, which results in activation of the gastric H+/K+ - ATPase. This enzyme is the final common pathway of acid secretion...
  10. pmc Acid, protons and Helicobacter pylori
    G Sachs
    Department of Medicine and Physiology, University of California, USA
    Yale J Biol Med 69:301-16. 1996
    The anti-ulcer drugs that act as covalent inhibitors of the gastric acid pump are targeted to the gastric H+/K+ ATPase by virtue of accumulation in acid and conversion to the active sulfenamide...
  11. pmc A screen for dominant negative mutants of SEC18 reveals a role for the AAA protein consensus sequence in ATP hydrolysis
    G J Steel
    The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Mol Biol Cell 11:1345-56. 2000
    ..does not prevent hexamerization or interaction with yeast alpha-SNAP (Sec17p), but instead results in undetectable ATPase activity that cannot be stimulated by Sec17p...
  12. ncbi Mechanisms of hypertension in diabetes
    J R Sowers
    Endocrinology Department, Wayne State University School of Medicine, Detroit, Michigan
    Am J Hypertens 4:177-82. 1991
    ..hyperinsulinemic, insulin-resistant Zucker rat demonstrates increased vascular reactivity, reduced membrane Ca2(+)-ATPase activity, increased cellular Ca2+ levels, and a marked impairment in vascular smooth muscle Ca2+ efflux compared ..
  13. ncbi [Classic treatment of chronic heart insufficiency. What if new?]
    M C Aumont
    Service de cardiologie A, Hopital Bichat, Paris
    Arch Mal Coeur Vaiss 88:599-602. 1995
    ..Digitalis has a positive inotropic effect (inhibition of NaK-dependent ATPase)...
  14. ncbi Heart failure: an update on pathophysiology
    H Drexler
    Medizinische Klinik III, University of Freiburg, Germany
    Arch Mal Coeur Vaiss 87:13-6. 1994
    ..Depressed expression of sarcoplasmatic reticulum ATPase is the hallmark of this overload phenotype...
  15. pmc Inhibitory effects of nordihydroguaiaretic acid on ETA-receptor-mediated contractions to endothelin-1 in rat trachea
    P J Henry
    Department of Pharmacology, University of Western Australia, Nedlands
    Br J Pharmacol 111:561-9. 1994
    ..5. Like NDGA, the sarcoplasmic reticulum Ca(2+)-ATPase inhibitors cyclopiazonic acid and thapsigargin inhibited contractions to ET-1, but not carbachol or KCl...
  16. pmc Effect of the Ca(2+)-ATPase inhibitor, cyclopiazonic acid, on electromechanical coupling in the guinea-pig ureter
    C A Maggi
    Pharmacology Department, A Menarini Pharmaceuticals, Florence, Italy
    Br J Pharmacol 114:127-37. 1995
    1. We have investigated the effect of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase inhibitor, cyclopiazonic acid (CPA), on electromechanical coupling in the guinea-pig ureter...
  17. ncbi [Baroreflexes and congestive heart failure]
    M C Aumont
    Service de cardiologie A, , Paris
    Arch Mal Coeur Vaiss 88:555-8. 1995
    ..Excessive Na-K dependent ATPase activation of the smooth muscle cells of the carotid sinus could lead to hyperpolarization of the cell membrane, ..
  18. pmc Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle
    J M Pak
    Liver Unit, University of Calgary Faculty of Medicine, AB Canada
    Br J Pharmacol 112:1209-15. 1994
    ..ester (10(-4) M) and capsaicin (50 mg kg-1) to block, respectively, beta-adrenoceptors, K+ -channels, Na+, K+-ATPase, nitric oxide synthase, and primary sensory nerves...
  19. ncbi The effects of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats
    K Higashiura
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 13:290-7. 2000
    ..the end of the glucose clamp, the soleus muscle was dissected for determination of the muscle fiber composition by ATPase methods...
  20. ncbi DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
    S Broomfield
    Department of Microbiology and Immunology, University of Saskatchewan, 107 Wiggins Road, SK, S7N 5E5, Saskatoon, Canada
    Mutat Res 486:167-84. 2001
    ..is centrally controlled by RAD6 and RAD18, whose products form a stable complex with single-stranded DNA-binding, ATPase and ubiquitin-conjugating activities...
  21. ncbi Expression of functionally P-glycoprotein in MA104 kidney cells
    M A Capella
    , , Universidade Federal do Rio de Janeiro, Brazil
    Z Naturforsch C 54:119-27. 1999
    ..epithelium with some unusual characteristics, including a resistance to ouabain, although their Na(+)-K(+)-ATPase has normal affinity with this drug...
  22. ncbi Isolation, characterization, and substrate specificity of the plasma membrane ATPase of the hlophilic achaeon Haloferax volcanii
    K Steinert
    , , Bundesrepublik Deutschland
    Z Naturforsch C 51:29-39. 1996
    Isolated membranes of the moderate halophilic bacterium Haloferax volcanii are able to hydrolyze ATP via an ATPase, which needs the presence of Mg2+ or Mn2+, high concentrations of NaCl, a pH value of 9, and high temperatures with an ..
  23. ncbi The pathophysiological and pharmacological basis of peptic ulcer therapy
    J W Freston
    University of Connecticut Health Center, Farmington 06032
    Toxicol Pathol 16:260-6. 1988
    ..cells, thereby preventing stimulation of adenylate cyclase, cAMP rises, and activation of protein kinase and H+/K+ATPase. Prostaglandins inhibit acid secretion largely by preventing histamine-induced cAMP rises...
  24. pmc Enhancement of arterial relaxation by long-term atenolol treatment in spontaneously hypertensive rats
    M Kahonen
    Department of Biomedical Sciences, University of Tampere, Finland
    Br J Pharmacol 112:925-33. 1994
    ..bath upon precontractions elicited by potassium-free solution were used to evaluate vascular smooth muscle Na+, K+-ATPase. The rate of potassium relaxation was fastest in WKY rats and was also faster in atenolol-treated than in ..
  25. pmc Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery
    A Suzuki
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 109:703-12. 1993
    ..6. In a solution containing MgITP (the substrate for myosin ATPase but not for MLC-kinase) with no MgATP, 10 microM Ca2+ failed to produce contraction...
  26. ncbi Molecular evolution of H+-ATPases. I. Methanococcus and Sulfolobus are monophyletic with respect to eukaryotes and Eubacteria
    J P Gogarten
    Biology Department, University of California, Santa Cruz 95064
    Z Naturforsch C 44:641-50. 1989
    ..of Methanococcus thermolithotrophicus genomic DNA corresponding to the catalytic domain of the membrane H+-ATPase. The deduced amino acid sequence was 54-58% identical to the approximately 70 kDa subunits of Sulfolobus ..
  27. pmc Inhibition of calcium release from the sarcoplasmic reticulum of rabbit aorta by hydralazine
    A M Gurney
    Department of Pharmacology, United Medical School, St Thomas s Hospital, London
    Br J Pharmacol 114:238-44. 1995
    ..Sequestration of Ca2+ would employ two pathways, one sensitive to inhibitors of the SR Ca(2+)-ATPase and the other to Ca antagonists...
  28. ncbi The energetic cost of protein synthesis in isolated hepatocytes of rainbow trout (Oncorhynchus mykiss)
    M C Pannevis
    Department of Zoology, University of Aberdeen, UK
    J Comp Physiol B 162:393-400. 1992
    ..8 +/- 2.8% on maintaining ouabain-sensitive Na+/K(+)-ATPase activity...
  29. ncbi The modulation of the calcium transport by skeletal muscle sarcoplasmic reticulum in the hibernating European hamster
    B Agostini
    , Heidelberg, Bundesrepublik Deutschland
    Z Naturforsch C 46:1109-26. 1991
    ..By contrast, the activity of the calcium dependent ATPase was not increased, suggesting a tighter coupling during hibernation between calcium dependent ATP-hydrolysis and ..
  30. pmc Rapid desensitization of adrenaline- and neuropeptide Y-stimulated Ca2+ mobilization in HEL-cells
    M C Michel
    Dept Medicine, University of Essen, Germany
    Br J Pharmacol 112:499-504. 1994
    ..4. In the absence of extracellular Ca2+ the endoplasmic reticulum Ca(2+)-ATPase inhibitor, thapsigargin, reduced hormone-stimulated Ca2+ elevations, demonstrating that mobilization occurs from a ..
  31. ncbi Alterations in erythrocyte plasma membrane ATPase activity and adenine nucleotide content in a spontaneously diabetic subline of the Chinese hamster
    D Bettin
    , Greifswald, Germany
    Horm Metab Res 28:1-6. 1996
    ..To study whether these abnormalities could affect transmembrane cation transport activity, we determined membrane ATPase activity and ATP concentrations in red blood cells of diabetes-resistant CHIA and diabetes-susceptible CHIG ..
  32. ncbi Regulation of the abundance of renal sodium transporters and channels by vasopressin
    C A Ecelbarger
    Division of Endocrinology and Metabolism, Georgetown University, Washington, DC 20007, USA
    Exp Neurol 171:227-34. 2001
    ..The alpha-subunit of Na-K-ATPase was increased by water restriction, but not by dDAVP infusion, and alpha-ENaC and the thiazide-sensitive ..
  33. pmc The superficial buffer barrier in venous smooth muscle: sarcoplasmic reticulum refilling and unloading
    Q Chen
    University of Miami School of Medicine, Department of Molecular and Cellular Pharmacology, FL 33101
    Br J Pharmacol 109:336-43. 1993
    ..5 mM Ca2+ solution and a 10 mM Ca2+ zero Na+ solution, respectively. Thapsigargin, 2 microM, (a specific SR Ca(2+)-ATPase blocker) completely blocked refilling of the SR in either of the above solutions, indicating that the SR Ca(2+)-..
  34. ncbi Effects of urinary ouabain-like factors and vanadium diascorbate on calcium mobilization in porcine inner medullary collecting duct cells: comparison with the effects of ouabain and vasopressin
    H J Kramer
    The Renal Section, Medical Policlinic, University of Bonn, Germany
    Am J Hypertens 11:1208-13. 1998
    ..OLF-1, OLF-2, and vanadium diascorbate inhibited dose-dependently porcine Na-K-ATPase in vitro...
  35. pmc Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform
    Y Amrani
    INSERM U 425, , Illkirch, France
    Br J Pharmacol 115:1204-10. 1995
    ..These stores appear to be controlled by the Ca2+-ATPases (SERCA2-b isoform) which could also participate in the regulation of Ca2+ influx through the plasma membrane...
  36. pmc The influence of acetazolamide and amlodipine on the intracellular sodium content of rat proximal tubular cells
    P S Wong
    Department of Physiology, Medical School, Birmingham
    Br J Pharmacol 112:881-6. 1994
    ..4. These data show that changes in the activity of the Na+/K+/ATPase have a considerable influence on the intracellular levels of sodium in proximal tubule cells...
  37. ncbi The Mfd protein of Bacillus subtilis 168 is involved in both transcription-coupled DNA repair and DNA recombination
    S Ayora
    , , E-28049, Madrid, Spain
    J Mol Biol 256:301-18. 1996
    ..The Mfd protein is a sequence-independent DNA binding protein with weak ATPase activity. The Mfd protein was able to displace in vitro B. subtilis or E. coli RNA polymerase stalled at a lesion...
  38. pmc Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity
    H Mäkynen
    Medical School, University of Tampere, Finland
    Br J Pharmacol 115:1455-62. 1995
    ..the organ bath upon precontractions in K(+)-free solution were used to evaluate the function of arterial Na+, K(+)-ATPase. The rate of potassium relaxation was similar in Ca-SHR and CaMg-SHR and faster than in untreated SHR. 5...
  39. ncbi Regulation of monovalent ion homeostasis and pH by the Ser-Thr protein phosphatase SIT4 in Saccharomyces cerevisiae
    C A Masuda
    , ICB-CCS, Universidade Federal do Rio de Janeiro, Rio de Janeiro, R.J. 21941-590, Brazil
    J Biol Chem 275:30957-61. 2000
    ..It has been proposed that the main pathway of salt tolerance in yeast is mediated by a P-type ATPase, encoded by PMR2A/ENA1...
  40. pmc Selective inhibition of agonist-induced but not shear stress-dependent release of endothelial autacoids by thapsigargin
    H Macarthur
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, Charterhouse Square, London
    Br J Pharmacol 108:100-5. 1993
    1. The effects of the Ca(2+)-ATPase inhibitor, thapsigargin, on the shear stress-dependent and on the agonist-stimulated release of endothelium-derived relaxing factor, i.e...
  41. ncbi An ecto-ATPase activity present in Leishmania tropica stimulated by dextran sulfate
    C E Peres Sampaio
    , , Universidade Federal do Rio de Janeiro, RJ, Brazil
    Z Naturforsch C 56:820-5. 2001
    In this study we report the effects of sulfated polysaccharides on the ecto-ATPase activity of intact cells of Leishmania tropica...
  42. ncbi The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function: a review
    M Rahman
    Department of Medicine, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4982, USA
    Am J Hypertens 10:356-65. 1997
    ..Vasodilation, vasoconstriction, inhibition of Na+,K+-ATPase, inhibition of ion transport and modulation of cell growth have been some of the diverse physiological actions ..
  43. ncbi Disturbances in volume regulating hormone system--a key to the pathogenesis of hypertension in obstructive sleep apnea syndrome?
    K Ehlenz
    Abt Für Endokrinologie und Stoffwechsel, Abt Poliklinik, Zentrum fur Innere Medizin, Universitat Marburg
    Pneumologie 45:239-45. 1991
    ..An inhibitor of the Na+/K(+)-ATPase acting via the digitalis receptor - called digitalis like factor (DLF) - is regarded as the causative agent for ..
  44. ncbi The signal transducer for the dopamine-1 regulated sodium transport in renal cortical brush border membrane vesicles
    C C Felder
    Section on Pharmacology, National Institute of Mental Health, Bethesda, Maryland
    Am J Hypertens 3:47S-50S. 1990
    ..DA-1 but not DA-2 agonists inhibit Na+/H+ exchange activity in brush border membrane vesicles (BBMV) and Na+/K(+)-ATPase activity in basolateral membranes...
  45. ncbi [Calcium-calmodulin and vasomotor activity]
    C Lugnier
    , CNRS URA 600, , Illkirch
    Arch Mal Coeur Vaiss 84:25-34. 1991
    ..to the relaxation of smooth muscle by inhibiting, the kinase of the myosine light chain and stimulating the Ca2+ ATPase responsible for the extrusion of Ca2+...
  46. ncbi Effect of chronic growth hormone administration on skeletal muscle in dogs
    S Molon Noblot
    Merck Sharp and Dohme Chibret Laboratories, Department of Safety Assessment, Riom, France
    Toxicol Pathol 26:207-12. 1998
    ..Quantitative analysis of skeletal muscle sections stained for ATPase activity showed increases in type I (slow twitch) and type II (fast twitch) myofiber sizes in mid- and high-dose ..
  47. ncbi Effect of thyroxine on cellular oxygen-consumption and glucose uptake: evidence of an effect of total T4 and not "free T4"
    J Kvetny
    Department of Clinical Chemistry and Internal Medicine C, Odense University Hospital, Denmark
    Horm Metab Res 22:485-9. 1990
    ..Inhibition of the NaK-ATPase by addition of ouabain (9-72 mg/l) did not inhibit T4 stimulation, thus indicating that the ouabain sensitive NaK-..
  48. ncbi Effect of insulin on norepinephrine overflow at peripheral sympathetic nerve endings in young spontaneously hypertensive rats
    T Shimosawa
    Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan
    Am J Hypertens 9:1119-25. 1996
    ..In contrast to insulin, direct stimulation of Na(+)-K+ ATPase with a high-potassium buffer (12 mmol/L) reduced NE overflow to the same extent among the four groups...
  49. ncbi Two separate genes encode the catalytic 70 kDa V-ATPase subunit in Psilotum and Equisetum
    T Starke
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269
    Z Naturforsch C 46:613-20. 1991
    ..lysosomes, chromaffin granules, vesicles derived from the Golgi apparatus, endosomes and vacuoles. Although this ATPase type is targeted to different compartments in one cell, only one gene for each subunit had been found per genome...
  50. pmc IgE-receptor activated chloride uptake in relation to histamine secretion from rat mast cells
    U G Friis
    Department of Pharmacology, Odense University, Denmark
    Br J Pharmacol 111:1179-83. 1994
    ..7. Ouabain (1 mM) which inhibits the Na+/K+ ATPase in rat peritoneal mast cells, failed to affect the uptake of chloride in resting mast cells. 8...
  51. ncbi Predominance of high molecular weight plasma Na(+)-K(+)-ATPase inhibitor in essential hypertension
    H C Gonick
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048
    Am J Hypertens 6:680-7. 1993
    Circulating inhibitors of the transport enzyme, sodium-potassium-activated adenosine triphosphatase (Na(+)-K(+)-ATPase), have been shown to be of possible pathogenetic importance in the mechanism of essential hypertension...
  52. ncbi Endogenous digoxin-like immunoactivity in subjects with diabetes mellitus and hypertension
    E Martinka
    Department of Internal Medicine I, Jessenius Faculty of Medicine, Commenius University, Martin, Slovakia
    Am J Hypertens 11:667-76. 1998
    ..None of the sera (n = 15) with different DLIA concentrations (0.0-0.38 nmol/L) exhibited K-pNPPase (Na+-K+-ATPase) inhibitory activity...
  53. pmc The mechanism of force generation in myosin: a disorder-to-order transition, coupled to internal structural changes
    D D Thomas
    Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455, USA
    Biophys J 68:135S-141S. 1995
    ..Some of these disordered heads are bound to actin, especially in the early (weak-binding, preforce) phase of the ATPase cycle...
  54. ncbi Dopamine-induced translocation of protein kinase C isoforms visualized in renal epithelial cells
    S Nowicki
    Department of Woman and Child Health, Karolinska Institute, Astrid Lindgren Children's Hospital, S-171 76 Stockholm, Sweden
    Am J Physiol Cell Physiol 279:C1812-8. 2000
    ..We used a proximal tubular-like cell line, LLCPK-1 cells, in which dopamine was found to inhibit Na(+)-K(+)-ATPase in a PKC-dependent manner...
  55. ncbi Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat
    H C Pitot
    McArdle Laboratory for Cancer Research Medical School, University of Wisconsin, Madison 53706
    Toxicol Pathol 17:594-611; discussion 611-2. 1989
    ..markers--gamma-glutamyltranspeptidase (GGT), a placental form of glutathione S-transferase (GST), canalicular ATPase, and glucose 6-phosphatase (G6Pase)--was described for the chemicals C.I...
  56. ncbi Spegazzinine, a new inhibitor of mitochondrial oxidative phosphorylation
    O A Roveri
    , , Universidad Nacional de Rosario, Suipacha 531, Rosario, Argentina
    Biochim Biophys Acta 333:187-94. 1974
    ..Oxygen uptake by submitochondrial particles was not affected. The 2,4-dinitrophenol-stimulated ATPase activity of rat liver mitochondria was not affected by 300 microM spegazzinine, a concentration of alkaloid that ..
  57. ncbi Higher salt consumption, digoxin-like factor, and nifedipine response are associated with salt sensitivity in essential hypertension
    V Dichtchekenian
    Department of Internal Medicine, Faculty of Medicine, , Brazil
    Am J Hypertens 5:707-12. 1992
    ..increased weight gain suggests volume expansion, a situation already shown to increase plasma levels of a Na, K-ATPase inhibitor...
  58. ncbi Increased acylphosphatase levels in erythrocytes, muscle and liver of tri-iodothyronine treated rabbits
    P Nassi
    Dipartimento di Scienze Biochimie, , Italy
    Horm Metab Res 22:33-7. 1990
    ..Besides acylphosphatase we assayed (Na+ + K+)-ATPase, Ca2(+)-ATPase and several enzymes of carbohydrate metabolism...
  59. ncbi Heart and hypertension
    R Fogari
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Am J Hypertens 2:16S-23S. 1989
    ..In the hypertrophied human ventricle, a decreased ATPase activity of myofibrils was observed, probably related to changes in myosin light chains...
  60. ncbi Role of digitalis-like substance in the hypertension of streptozotocin-induced diabetes in reduced renal mass rats
    S Chen
    Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799
    Am J Hypertens 6:397-406. 1993
    ..The same was the case for plasma digitalis-like substance (DLS), determined by exposing canine Na+,K(+)-ATPase to plasma fractions and observing the percent inhibition...
  61. pmc Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites
    M M Anderson
    Department of Microbiology, Michigan State University, East Lansing 48824, USA
    J Virol 70:6304-13. 1996
    ..and -independent mechanisms; (iii) the T-Ag pRb family-binding domain, but not the p53-binding, helicase, or ATPase domain, is required for activation; and (iv) activation is severely diminished with a TK promoter fragment in ..
  62. ncbi Effect of respiratory acidosis and respiratory alkalosis on renal transport enzymes
    S Eiam Ong
    Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430
    Am J Physiol 267:F390-9. 1994
    ..acidosis and respiratory alkalosis on acid-base composition and on microdissected renal adenosinetriphosphatase (ATPase) enzymes. Rats were subjected to hypercapnia or hypocapnia of 6, 24, and 72 h duration...
  63. ncbi Changes in lipid peroxidation, the redox system and ATPase activities in plasma membranes of rice seedling roots caused by lanthanum chloride
    H L Zheng
    Department of Biology, Xiamen University, PR China
    Biometals 13:157-63. 2000
    ..The effects of lanthanum chloride (LaCl3) on the activities of lipid peroxidation, the redox system and H+-ATPase, Ca2+-ATPase of plasma membranes were studied...
  64. ncbi Cloning and molecular characterisation of the trout (Oncorhynchus mykiss) vacuolar H(+)-ATPase B subunit
    S F Perry
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada K1N 6N5
    J Exp Biol 203:459-70. 2000
    ..of transepithelial ion movements in the gill of freshwater fish incorporates an apically oriented vacuolar H(+)-ATPase (H(+)V-ATPase; proton pump) that is believed to facilitate both acid excretion and Na(+) uptake...
  65. pmc Possible role of Na(+)-K(+)-ATPase in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide
    S Gupta
    Department of Urology, Boston University School of Medicine, MA 02118, USA
    Br J Pharmacol 116:2201-6. 1995
    1. This study was designed to determine the role of sodium-potassium adenosine triphosphatase (Na(+)-K(+)-ATPase) in the regulation of human corpus cavernosum smooth muscle contractility by nitric oxide (NO)...
  66. ncbi Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling
    Valerie Beaulieu
    Program in Membrane Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:8452-63. 2005
    ..by the calcium-activated actin-capping and -severing protein gelsolin plays a key role in regulating vacuolar H(+)-ATPase (V-ATPase) recycling...
  67. ncbi Identification of the subunits of F1F0-ATPase from bovine heart mitochondria
    J E Walker
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, U K
    Biochemistry 30:5369-78. 1991
    An oligomycin-sensitive F1F0-ATPase isolated from bovine heart mitochondria has been reconstituted into phospholipid vesicles and pumps protons...
  68. ncbi The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity
    J Bełtowski
    Department of Pathophysiology, Medical University, Lublin, Poland
    J Physiol Pharmacol 53:211-31. 2002
    ..The aim of this study was to investigate in vivo the effect of PKA on renal Na, K-ATPase activity. The study was performed in male Wistar rats...
  69. ncbi Photosensitizing effects of hematoporphyrin derivative and photofrin II on the plasma membrane enzymes 5'-nucleotidase, Na+K+-ATPase, and Mg2+-ATPase in R3230AC mammary adenocarcinomas
    S L Gibson
    Department of Biochemistry, University of Rochester School of Medicine and Dentistry, New York 14642
    Cancer Res 48:3360-6. 1988
    ..The activities of Na+K+-ATPase, Mg2+-ATPase and 5'-nucleotidase in isolated membranes were measured after exposure of membranes to either ..
  70. ncbi P-type Na+/K+-ATPase and V-type H+-ATPase expression patterns in the osmoregulatory organs of larval and adult mosquito Aedes aegypti
    Marjorie L Patrick
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521 0146, USA
    J Exp Biol 209:4638-51. 2006
    This study describes the expression patterns of P-type Na(+)/K(+)-ATPase and V-type H(+)-ATPase in the larval and adult forms of the mosquito Aedes aegypti and provides insight into their relative importance in ion transport function of ..
  71. pmc Delta protein kinase C interacts with the d subunit of the F1F0 ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester. Implications for F1F0 ATPase regulation
    Tiffany Nguyen
    Department of Pharmacology and Toxicology, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912 2300, USA
    J Biol Chem 283:29831-40. 2008
    ..We have, therefore, evaluated protein kinase C modulation of the F(1)F(0) ATPase in neonatal cardiac myocytes...
  72. ncbi Ultracytochemical location of Na(+)/K(+)-atpase activity and effect of high salinity acclimation in gill and renal epithelia of the freshwater shrimp Macrobrachium olfersii (Crustacea, Decapoda)
    J C McNamara
    Departamento de Biologia, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brasil
    J Exp Zool 284:617-28. 1999
    Accumulation sites of lead phosphate reaction product consequent to Na(+)/K(+)-ATPase activity in gill and renal epithelia of the freshwater shrimp Macrobrachium olfersii were located ultracytochemically by para-nitrophenyl-phosphate ..
  73. ncbi [Effects of methyl jasmonate treatment on the hydrolytic activity and phosphorylation level of plasma membrane H+-ATPase in mung bean (Vigna radiata L.) hypocotyls]
    Bin Wen
    Institute of Piwei, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China
    Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 30:665-70. 2004
    ..kinase inhibitors and phosphatase inhibitors to investigate the effect of MeJA (methyl jasmonate) on the H+-ATPase hydrolytic activity of plasma membrane, and the regulations involved with phosphorylation and dephosphorylation of ..
  74. ncbi Distribution of (Na+ + K+)ATPase and sodium channels in skeletal muscle and electroplax
    R G Ariyasu
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla 92093
    J Neurocytol 16:511-22. 1987
    The distributions of (Na+ + K+)ATPase and sodium channels in skeletal muscle fibres and electrocytes were determined by immunofluorescent and immunoelectron microscopic techniques using antibodies against rat and eel (Na+ + K+)ATPase and ..
  75. doi Effects of short-term exposure to manganese on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na,K)-ATPase and Mg-ATPase: modulation by L-cysteine
    Charis Liapi
    Department of Pharmacology, Medical School, University of Athens, Greece
    Basic Clin Pharmacol Toxicol 103:171-5. 2008
    ..on the adult rat brain total antioxidant status (TAS) and the activities of acetylcholinesterase (AChE), Na+,K+-ATPase and Mg2+-ATPase induced by short-term Mn administration (as Mn chloride, 50 mg/kg)...
  76. ncbi Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids
    Li Yan Qiu
    Department of Biochemistry 160, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Biol Chem 280:32349-55. 2005
    ..glycosides have been used as drugs for more than 2 centuries and their primary target, the sodium pump (Na,K-ATPase), has already been known for 4 decades, their exact binding site is still elusive...
  77. pmc Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1
    Christian Hauck
    Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Cologne, Germany
    Eur J Pharmacol 622:7-14. 2009
    Cardiac glycosides inhibit the Na(+),K(+)-ATPase and are used for the treatment of symptomatic heart failure and atrial fibrillation...
  78. pmc Analysis of F1F0-ATPase from Helicobacter pylori
    C C McGowan
    Department of Medicine, Vanderbilt University School of Medicine, and Department of Veterans Affairs Medical Center, Nashville, Tennessee 37232 2605, USA
    Infect Immun 65:2640-7. 1997
    ..The proton-translocating F1F0-ATPase is an important enzyme for regulating intracellular pH or synthesizing ATP in many other enteric bacteria; ..
  79. ncbi Immunolocalization of CA II and H+ V-ATPase in epithelial cells of the mouse and rat epididymis
    L Hermo
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    J Androl 21:376-91. 2000
    ..anhydrase II (CA II) and a 67-kd subunit of Neurospora crassa vacuolar proton adenosinetriphosphatase (H+ V-ATPase) pump were immunolocalized using light microscopy and electron microscopy (EM) in the epididymis of rats and mice...
  80. ncbi Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats
    Tania Akhter
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 18:171-6. 2006
    The role of regucalcin, a regulatory protein in intracellular signaling system, in the regulation of Ca2+-ATPase activity in rat heart mitochondria was investigated...
  81. ncbi [Altered expression of mitochondrial DNA encoding ATP 6, 8 and encoding protein in energy metabolism during cold preservation and reperfusion injury in rat liver transplantation]
    Ying Zhang
    Department of Hepatobiliary Surgery, Guizhou Provincial People s Hospital, Guiyang 550002, China
    Zhonghua Yi Xue Za Zhi 90:708-11. 2010
    ..changes of mitochondrial (mt) DNA encoding ATP6, 8 of hepatocytes in rat liver transplantation with cold preservation-reperfusion and explore the relationship between the expression of F(0)F(1)-ATPase induced by changes of ATP 6, 8 genes.
  82. ncbi Vacuolar and plasma membrane proton-adenosinetriphosphatases
    N Nelson
    Department of Biochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Physiol Rev 79:361-85. 1999
    The vacuolar H+-ATPase (V-ATPase) is one of the most fundamental enzymes in nature. It functions in almost every eukaryotic cell and energizes a wide variety of organelles and membranes...
  83. ncbi Mutations affecting lysine-35 of gpNu1, the small subunit of bacteriophage lambda terminase, alter the strength and specificity of holoterminase interactions with DNA
    Y Hwang
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Virology 231:218-30. 1997
    The small subunit of lambda terminase, gpNu1, contains a low-affinity ATPase activity that is stimulated by nonspecific dsDNA...
  84. ncbi [3H]Bafilomycin as a probe for the transmembrane proton channel of the osteoclast vacuolar H(+)-ATPase
    J P Mattsson
    Department of Cell Biology, ASTRA HASSLE AB, Molndal, Sweden
    Biochim Biophys Acta 1280:98-106. 1996
    Bone resorption by the osteoclast is dependent on acidification of the bone surface by a vacuolar type H+-ATPase (V-ATPase) present in the ruffled membrane of the actively resorbing cell...
  85. ncbi Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
    M Flesch
    Klinik III fur Innere Medizin, Universitat Koln, Germany
    J Mol Med (Berl) 74:321-32. 1996
    ..diastole has been explained by the impairment of Ca2+ uptake into the sarcoplasmic reticulum (SR) via the SR Ca2+ATPase. It is unclear whether Ca2+ATPase function, protein levels, and mRNA steady-state levels correspond to one other, ..
  86. ncbi Photoinactivation of the F1-ATPase from spinach chloroplasts by dequalinium is accompanied by derivatization of methionine beta183
    H M Ren
    Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093 0601, USA
    J Biol Chem 272:32294-300. 1997
    ..thermophilic Bacillus PS3, which are reversibly inhibited by dequalinium in the absence of irradiation, the Mg2+-ATPase activity of heat- or dithiothreitol-activated chloroplast F1 (CF1) from spinach chloroplasts is slightly ..
  87. ncbi Site-directed mutagenesis within an ectoplasmic ATPase consensus sequence abrogates the cell aggregating properties of the rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 and carcinoembryonic antigen
    C J Sippel
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 271:33095-104. 1996
    Recent studies of the rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 (CBATP), a member of the carcinoembryonic antigen (CEA) supergene family, indicate that it is a multifunctional protein possessing bile acid efflux,..
  88. ncbi Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes
    Y Moriyama
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    J Biol Chem 263:8521-7. 1988
    A vanadate- and N-ethylmaleimide-sensitive ATPase was purified about 500-fold from chromaffin granule membranes...
  89. ncbi H(+)V-ATPase-dependent luminal acidification in the kidney collecting duct and the epididymis/vas deferens: vesicle recycling and transcytotic pathways
    D Brown
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, MA 02129, USA
    J Exp Biol 203:137-45. 2000
    ..epithelia contain characteristic 'mitochondria-rich' cells that express high levels of a vacuolar proton-pumping ATPase (H(+)V-ATPase) on their plasma membrane and on intracellular vesicles...
  90. doi Interaction between cardiotonic steroids and Na,K-ATPase. Effects of pH and ouabain-induced changes in enzyme conformation
    Flemming Cornelius
    Department of Physiology and Biophysics, University of Aarhus, Ole Worms Alle 1185, 8000 Aarhus C, Denmark
    Biochemistry 48:10056-65. 2009
    The Na,K-ATPase belongs to the P-type ATPase family of primary active cation pumps. It maintains the transmembrane gradients of Na(+) and K(+) across the cell membrane essential for cell homeostasis...
  91. ncbi Phosphorylation of phospholamban by cAMP-dependent protein kinase enhances interactions between Ca-ATPase polypeptide chains in cardiac sarcoplasmic reticulum membranes
    S Negash
    Department of Biochemistry, University of Kansas, Lawrence 66045 2106, USA
    Biochemistry 35:11247-59. 1996
    ..in protein-protein interactions that accompany the activation of the cardiac sarcoplasmic reticulum (SR) Ca-ATPase following the phosphorylation of phospholamban (PLB)...
  92. ncbi High levels of E-/P-cadherin: correlation with decreased apical polarity of Na/K ATPase in bovine RPE cells in situ
    J M Burke
    Department of Ophthalmology and Cell Biology, Medical College of Wisconsin, Milwaukee, USA
    Invest Ophthalmol Vis Sci 41:1945-52. 2000
    The adherens junction protein E-cadherin induces a basolateral polarity of Na/K ATPase in most epithelial cells that express it, whereas in retinal pigment epithelium (RPE) cells, Na/K ATPase is largely apical...
  93. ncbi Na,K-ATPase in skeletal muscle: two populations of beta-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and the transverse tubules
    M W Williams
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 114:751-62. 2001
    We used immunological approaches to study the factors controlling the distribution of the Na,K-ATPase in fast twitch skeletal muscle of the rat...
  94. pmc C-peptide, Na+,K(+)-ATPase, and diabetes
    P Vague
    Departement de Nutrition Endocrinologie Maladies Métaboliques, CHU Timone, Marseille, France
    Exp Diabesity Res 5:37-50. 2004
    Na+,K(+)-ATPase is an ubiquitous membrane enzyme that allows the extrusion of three sodium ions from the cell and two potassium ions from the extracellular fluid...
  95. pmc Immunochemical characterization of two isoforms of rat liver ecto-ATPase that show an immunological and structural identity with a glycoprotein cell-adhesion molecule with Mr 105,000
    S H Lin
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem J 278:155-61. 1991
    ..The Mr and localization of cell-CAM105 in liver membranes are very similar to those of liver ecto-ATPase, an ATPase with its nucleotide-hydrolysing site localized on the outside of the cell membrane...
  96. ncbi The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat
    F Ildan
    Department of Neurosurgery, Cukurova University School of Medicine, Balcali Adana 01330, Turkey
    Neurol Res 23:96-104. 2001
    ..The effects of nimodipine, a calcium antagonist, on the Na(+)-K+/MG+2 ATPase activity, Ca+2/Mg+2 ATPase, lipid peroxidation, and early ultrastructural findings were examined at the acute ..
  97. doi [Discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis]
    Yo ichi Nabeshima
    Kyoto University Graduate School of Medicine
    Clin Calcium 18:923-34. 2008
    ..actions of alpha-Klotho (alpha-Kl) and FGf23 can be summarized as follows ; (i) alpha-Kl binds to Na(+), K(+)-ATPase, and Na(+), K(+)-ATPase is recruited to the plasma membrane by a novelalpha-Kl dependent pathway in correlation ..
  98. doi Blood-brain barrier Ca2+-ATPase cytochemistry: incubation media and fixation methods for differentiating Ca2+-specific ATPase from ecto-ATPase
    P S Manoonkitiwongsa
    Neural Engineering Program, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    Biotech Histochem 85:257-68. 2010
    Ca2+-ATPase cytochemistry frequently uses the incubation medium of Ando et al. that was introduced in 1981...
  99. ncbi The influence of SRC-family tyrosine kinases on Na,K-ATPase activity in lens epithelium
    Larry D Bozulic
    Department of Biochemistry, University of Louisville, School of Medicine, KY 40292, USA
    Invest Ophthalmol Vis Sci 46:618-22. 2005
    Na,K-adenosine triphosphatase (ATPase) is essential for the regulation of cytoplasmic ion concentrations in lens cells...
  100. ncbi Either the carboxyl- or the amino-terminal region of the human ecto-ATPase (E-NTPDase 2) confers detergent and temperature sensitivity to the chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8)
    Takashi Mukasa
    Department of Chemistry and Biochemistry, San Diego State University, San Diego, California 92182 1030, USA
    Biochemistry 44:11160-70. 2005
    Human ecto-ATPase (E-NTPDase 2) and chicken ecto-ATP-diphosphohydrolase (E-NTPDase 8) are cell surface nucleotidases with two transmembranous domains, one each at the N- and C-termini...
  101. doi Response of Na(+)-dependent ATPase activities to the contaminant ammonia nitrogen in Tapes philippinarum: possible atpase involvement in ammonium transport
    Alessandra Pagliarani
    Department of Biochemistry G Moruzzi, Section of Veterinary Biochemistry, University of Bologna, Via Tolara di Sopra, 50, 40064, Ozzano Emilia, BO, Italy
    Arch Environ Contam Toxicol 55:49-56. 2008
    ..vivo and in vitro experiments elicited different responses to ammonia nitrogen (ammonia-N) of gill and mantle Na,K-ATPase and ouabain-insensitive Na-ATPase activities in the Philippine clam Tapes philippinarum...

Research Grants116 found, 100 shown here

  1. Axial Flow Effects in Proximal Tubule
    TONG WANG WANG; Fiscal Year: 2012
    ..b) Both luminal membrane NHE3 and H-ATPase are regulated by flow;c) Changes in tight junction permeabilities do not play a role in flow-modulated transport...
  2. Silvia N Moreno; Fiscal Year: 2016
    ..Physiological studies further revealed similarities to plant vacuoles such as the presence of a V-H+ATPase, Na? and Ca2? antiporters, and calcium storage...
  3. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..hearts from both humans and animal models and has been associated with a decrease in the activity of the SR Ca2+-ATPase (SERCA2a), which is at least partially due to enhanced phospholamban (PLN) inhibition...
  4. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    The Sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) plays a dominant role in Ca2+ removal and is responsible for maintaining cardiac SR Ca2+ store...
  5. Seth L Robia; Fiscal Year: 2014
    ..3) Regulatory partners continually bind and unbind from the pump with fast kinetics. By measuring ATPase structures and motions in live cardiac cells, we will gain new insight into mechanisms that become disrupted in ..
  6. Christos S Katsanos; Fiscal Year: 2015
    ..The abundance of the beta subunit of the ATP synthase ([unreadable] -F1-ATPase) in muscle mitochondria is decreased in obese, insulin-resistant individuals...
  7. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2013
    ..which directly reflects the product between the coupling efficiency of the electron transport chain to the F1F0-ATPase reaction in the mitochondria and the rate of cerebral oxygen consumption (CMRO2);the validation and establishment ..
  8. Roberto Docampo; Fiscal Year: 2016
    ..The acidocalcisome membrane contains a number of pumps (Ca2+- ATPase, V-H+-ATPase, H+-PPase), exchangers (Na+/H+, Ca2+/H+), and channels (aquaporins), while its matrix contains ..
  9. H+-ATPase B-subunit Dysfunction and Calcium Nephrolithiasis
    Orson W Moe; Fiscal Year: 2010
    ..This proposal focuses on the B1 subunit of the V-ATPase. The heterozygous carrier state is universaly believed to be silent...
  10. Na,K-ATPase as an Integrator of the Calcium-signaling Machinery
    Zijian Xie; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Na/K-ATPase belongs to the family of P-type ATPases and was discovered as an energy transducing ion pump...
  11. Chia Ling Tu; Fiscal Year: 2014
    ..complex with modulators of Ca2+i stores and store-operated channels (SOC), including IP3R, PLC31 and a Ca2+-ATPase SPCA1 in the Golgi, which is a major Ca2+I reservoir in keratinocytes...
  12. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..The receptor that might mediate these presynaptic effects is unknown but a good candidate is the a3 Na,K-ATPase (NKA), a neuron-specific isoform of the sodium-potassium pump that binds all forms of agrin...
  13. Role for Na,K-ATPase in Nucleoplasmic Calcium Homeostasis
    Craig Gatto; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The sodium-potassium adenosine triphosphatase (i.e. Na,K-ATPase) is responsible for controlling cellular fluid and electrolyte balance in higher eukaryotes...
  14. Joseph Y Cheung; Fiscal Year: 2014
    ..of small integral membrane proteins involved in regulation of ion transport, modulates the function of both Na+-K+-ATPase and Na+/Ca2+ exchanger (NCX1) in the heart...
  15. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..of the SER also suggests that ethanol-related alterations may have occurred in the sarcoplasmic reticulum calcium ATPase (SERCA) pump that resequesters calcium into the SER lumen following calcium signaling...
  16. Design of Slack Channel Activators
    Heike Wulff; Fiscal Year: 2012
    ..role in protecting cells from injury under ischemic conditions, when inhibition of the plasma membrane Na+-K+-ATPase by the lack of oxygen leads to an increase in intracellular sodium levels...
  17. Exercise Training in Post-infarct Heart
    Joseph Y Cheung; Fiscal Year: 2012
    ..the current grant period, we focused on the cardiac Na+/Ca2+ exchanger (NCX1) and sarco(endo)plasmic reticulum Ca-ATPase (SERCA2) as targets by which HIST mediated its beneficial effects...
  18. Yingjie Chen; Fiscal Year: 2014
    ..We also found that BP1/2 DKO increased LV sarcoplasmic reticulum Ca++ ATPase (SERCA2a) protein content ~2.5 fold at the protein level...
    Georges E Haddad; Fiscal Year: 2011
    ..identified in alcoholic hearts and has been associated with a decrease in the expression and activity of SR Ca2+-ATPase (SERCA2a) along with changes in the expression of phospholamban...
  20. Gianluigi Veglia; Fiscal Year: 2016
    ..In cardiac myocytes, the SR Ca2+-ATPase 2a isoform (SERCA2a) is responsible for ~70% of the Ca2+ translocation and regulates diastole...
  21. David D Thomas; Fiscal Year: 2016
    ..We focus on two integral membrane proteins, the sarcoplasmic reticulum (SR) Ca-ATPase (SERCA) and its principal regulator in the heart, phospholamban (PLB)...
  22. Roger J Hajjar; Fiscal Year: 2014
    ..has recently completed a First-in-Man Phase 1 and Phase 2 trials targeting the sarcoplasmic reticulum calcium ATPase pump (SERCA2a) using adenoassociated vector type 1 AAV1.SERCA2a...
  23. Structural Dynamics of Cardiac Calcium Transport Regulation
    NAA ADJELEY DROMOH ABLORH; Fiscal Year: 2013
    ..The focus is on the Ca-ATPase (SERCA), the large integral membrane enzyme that pumps calcium into the SR and thus relaxes the muscle, and ..
  24. Structure and function of human phospholamban pentamer
    James J Chou; Fiscal Year: 2010
    ..3) Characterize the inhibitory interaction between the PLB pentamer and the SR calcium pump (Ca2+ATPase) by NMR chemical shift perturbation, fluorescence energy transfer, and potentially crystallographic methods...
  25. Organization of Sarcoplasmic Reticulum in Skeletal Muscle
    Robert J Bloch; Fiscal Year: 2012
    ..ryanodine receptors) that open to initiate contraction, and the network SR, which contains much of the Ca2+-ATPase (SERCA) responsible for removing Ca2+ from the myoplasm, leading to relaxation...
  26. Gianluigi Veglia; Fiscal Year: 2015
    ..PLN binds and inhibits the SR Ca-ATPase (SERCA), regulating heart diastole...
  27. Effect of Mitral Regurgitation on Ischemic LV Remodeling
    Robert A Levine; Fiscal Year: 2013
    ..repair by shunt closure reversed remodeling, while early transgenic overexpression of sarcoplasmic reticulum Ca+2-ATPase (SERCA2a) improved it...
  28. L Jeannine Brady; Fiscal Year: 2016
    ..This is largely mediated by a multi-subunit F1F0 ATPase that spans the cytoplasmic membrane, cleaves ATP and pumps protons from the cell...
  29. Computationally designed phospholamban-SERCA for rectifying diabetic cardiomyopa
    ..SR) Ca2+ content is a major contributor to DCM, and deficient Ca2+ uptake by the sarcoplasmic reticulum Ca2+ ATPase (SERCA) is partially at fault...
  30. SARA MARIE RASER PALMER; Fiscal Year: 2014
    ..mutans in a rat caries model, while deletion of both genes is lethal. Moreover, stress tolerance, H+-ATPase activity, and biofilm formation are decreased in yidC mutants, with more severe effects observed upon deletion of ..
  31. Calcium Signaling in Pancreatic Beta Cell Endoplasmic Reticulum
    MICHAEL WILLIAM ROE; Fiscal Year: 2010
    ..Preliminary studies suggest that sarcoendoplasmic reticulum Ca2+-ATPase (SERCA), a key regulator of ER Ca2+ homeostasis, is impaired in islets from the db/db mouse model of T2DM...
  32. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    ..derived using this single molecule technology will be paralleled with functional studies of force development, ATPase on skinned papillary muscle fibers as well as force and calcium transients on intact muscle fibers from transgenic ..
  33. Helmy M Siragy; Fiscal Year: 2016
    ..Recent studies suggested interaction of this receptor with vacuolar H+ATPase (V-ATPase) and Wnt signaling pathways...
  34. The Role of a Cerebello-Thalamo-Basal Ganglia Pathway in Dystonia
    Rachel Fremont; Fiscal Year: 2013
    ..In rodents, perfusing a selective Na/K ATPase (sodium pump) blocker ouabain into the cerebellum results in dystonia...
  35. JAMES ALVIN BALSCHI; Fiscal Year: 2014
    ..exchange correlates with the activity of the yeast cellular membrane major ion transport protein, the P-type H+-ATPase. We also have preliminary data from the heart that water exchange correlates with Na+,K+-ATPase activity...
  36. Jacob I Sznajder; Fiscal Year: 2016
    ..fluid clearance is affected mostly by vectorial Na+ transport, via apical Na+ channels and basolateral Na,K-ATPase in the alveolar epithelium...
  37. Epithelial Na Channels: Structure-Function Studies
    Thomas R Kleyman; Fiscal Year: 2010
    ..mediate reabsorptive sodium transport across epithelial cell layers in conjunction with a basolateral Na+/K+-ATPase. These channels have a key role in the regulation of urinary Na+ reabsorption, extracellular fluid volume ..
  38. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..measure reactive oxygen species, determine the redox status of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), and assess intracellular Ca2+...
  39. RAYMOND CHARLES KOEHLER; Fiscal Year: 2016
    ..D1 receptor activation amplifies NMDA channel calcium currents by NR1 phosphorylation and decreases Na,K-ATPase activity...
  40. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..Aim 3. Determine how the dynamic trio - L-VGCC, retinoschisin (rs1), and plasma membrane Ca2+-ATPase (PMCA1) - promote membrane retention of L-VGCCs and Ca2+ homeostasis...
  41. Paras Kumar Mishra; Fiscal Year: 2016
    ..HHcy and HFD also down regulates sarco-endoplasmic reticulum ATPase 2a (serca2a;regulates calcium flux during muscle contraction), which is improved by exercise and H2S...
  42. Sylvie Breton; Fiscal Year: 2015
    ..funding periods, we showed that luminal acidification is achieved by clear cells, via the proton pumping V-ATPase, and that it can be regulated via crosstalk with surrounding epithelial cells...
  43. Calcium Regulation in Airway Smooth Muscle
    Gary C Sieck; Fiscal Year: 2013
    ..by plasma membrane (PM) efflux mechanisms (perhaps including NCX-mediated efflux), and by SR Ca2+ reuptake via SR ATPase (SERCA). Organelles such as mitochondria can buffer Ca2+ and alter Ca2+ availability for SR refilling...
  44. GLADYS Y KO; Fiscal Year: 2014
    ..We have further identified a new binding partner of retinoschisin, the plasma membrane Ca2+-ATPase (PMCA1), a Ca2+ pump that is important in excreting excessive intracellular Ca2+ from photoreceptors...
  45. Sanford I Bernstein; Fiscal Year: 2016
    ..Using transgenic Drosophila, we will assess effects upon myosin structure, ATPase activity, in vitro motility, indirect flight and jump muscle ultrastructure, fiber mechanics and organism ..
  46. CARMELLA EVANS EVANS-MOLINA; Fiscal Year: 2016
    ..The sarco-endoplasmic reticulum calcium ATPase (SERCA) pump resides in the ER membrane and is tasked with maintaining a steep calcium concentration gradient ..
  47. Dynamics of pH Regulation in the Brain
    Mitchell Chesler; Fiscal Year: 2013
    ..a rise in extracelluar pH can be detected that is caused by activation of the plasma membrane calcium ATPase (PMCA), as it pumps out calcium in exchange for extracellular hydrogen ions...
  48. CARMELLA EVANS EVANS-MOLINA; Fiscal Year: 2016
    ..The sarco-endoplasmic reticulum calcium ATPase or SERCA pump resides in the endoplasmic reticulum membrane and is responsible for maintaining a steep calcium ..
  49. Yersinia Type III Transport of Yop Proteins into Immune Cells
    Olaf Schneewind; Fiscal Year: 2013
    ..of YscU, the switch protein, and its variable interaction with other machine components, including the type III ATPase complex (YscN-YscK-YscL-YscQ) and YscO...
  50. Molecular basis of Ca2+ leak in heart
    GEORGE BLAIR WILLIAMS; Fiscal Year: 2013
    ..role in maintaining healthy cellular Ca2+ content by balancing uptake from the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) pump...
  51. Donald M Bers; Fiscal Year: 2015
    ..hypertrophic signaling and will assess how 1) altered Na influx via Na channels and 2) altered Na efflux via Na/K-ATPase regulate myocyte Ca and Hyp, and 3) how cyclophilin D &permeability transition pore regulate mitochondrial Ca...
  52. GREGORY DAVID GILLISPIE; Fiscal Year: 2014
    ..is to develop a high-performance assay for an important protein target, SERCA, the sarco(endo)plasmic reticulum Ca-ATPase, which is key to calcium regulation in all mammalian cells, and of particular interest in heart failure therapies...
  53. Hydroquinone derivatives as novel calcium ATPase inhibitors
    STEFAN FRANZ PAULA; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Commonly used inhibitors of the enzyme sarco/endoplasmic reticulum calcium-ATPase (SERCA) derived from the natural product thapsigargin (TG) suffer from limitations attributed to their high structural ..
  54. Stephan Wilkens; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The vacuolar type H+ATPase (V1Vo- or V-ATPase) is a fundamental component of all eukaryotic cells...
    Steven L Teitelbaum; Fiscal Year: 2013
    ..Bone resorption necessitates extracellular proton transport as a result of insertion of the vacuolar H+ATPase into the bone-apposed OC plasma membrane and targeted secretion of the collagenolytic enzyme cathepsin K...
  56. George J Schwartz; Fiscal Year: 2014
    ..There are two functionally distinct subtypes: A-ICs secrete protons via an apical H+ATPase and basolateral Cl-/HCO3- exchanger (kidney AE1), while B-ICs secrete bicarbonate via a basolateral H+ATPase and ..
  57. ALEXANDER A TZAGOLOFF; Fiscal Year: 2014
    ..mutants of the unicellular yeast Saccharomyces cerevisiae to study the mechanisms by which the H+ translocating ATPase (F1-F0 ATPase), the bc1 complex and mitochondrial ribosomes are assembled...
  58. The Role of PLEKHM1 in Osteoclast Function
    Haibo Zhao; Fiscal Year: 2010
    ..of genes such as c-src, [unreadable]3 integrin subunit, cathepsin K, TCIRG1 (encoding a3 subunit of vacuolar H+-ATPase), CLCN7 (encoding clc-7 chloride channel) and OSTM1 (grey lethal) disrupts osteoclast function...
    Alexander Tzagoloff; Fiscal Year: 2009
    ..have also continued studies on the mechanism of assembly of complex membrane enzymes such as the H+-translocating ATPase, the bc1 complex and more recently mitochondrial ribosomes...
    Robert H Edwards; Fiscal Year: 2011
    ..and hence depends on a H+ electrochemical driving force (?[unreadable]H+) generated by the vacuolar-type H+-ATPase. However, different transmitters depend to varying extents on the two components of ?[unreadable]H+, the chemical ..
  61. Signal Transduction in Intrapulmonary Chemoreceptors
    Steven C Hempleman; Fiscal Year: 2010
    ..Aim I of this proposal will test whether active proton transport by v-type H+ ATPase and H+/K+-ATPase participate in pH regulation and CO2 transduction in IPC...
  62. Energy Coupling and Regulation in the ATP Synthase of E. coli
    Thomas M Duncan; Fiscal Year: 2012
    ..coli F1-ATPase. This structural work is aimed at providing atomic snapshots the EcF1-[unreadable] with the [unreadable] subunit ..
  63. Laurie J Ozelius; Fiscal Year: 2016
    ..TorsinA is a AAA-ATPase protein and Thap1 is a transcription factor...
  64. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..factor (EDLF), an unknown substance that cross reacts with anti-digoxin antibodies and inhibits the Na+/K+ ATPase (NKA) was first noted in the 1980s...
  65. Immunobiology of Acute Environmental Asthma
    David B Peden; Fiscal Year: 2013
    ..Furthermore we have shown that both of these proteins are ATP-binding proteins, and they exhibit ATPase activity, thus providing ways to modulate their function, which might be important leads to drug discovery...
  66. Tahir Hussain; Fiscal Year: 2016
    ..activation of the AT2 receptors stimulated a nitric oxide/cGMP pathway, thus inhibiting proximal tubule Na,K-ATPase (NKA) activity and increasing urinary Na excretion in obese Zucker rats, a model of insulin resistance and ..
  67. Douglas E Koshland; Fiscal Year: 2015
    ..antagonist in cohesin binding to chromosomes by exploiting dominant negative phenotypes of cohesin's Smc3 ATPase and by suppression analysis of its defective loader...
  68. Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NURIA M PASTOR-SOLER; Fiscal Year: 2013
    Abstract. V-ATPase function in kidney is important for excretion of non-volatile acids generated by metabolism...
  69. David E Wemmer; Fiscal Year: 2014
    ..coupling of chemical sensing to changes in rates of transcription at specific genes, a process mediated by an ATPase activity in required transcriptional activator proteins...
  70. Dennis Brown; Fiscal Year: 2016
    Defects in V-ATPase-dependent acidification in the kidney collecting duct results in distal tubular acidosis and nephrolithiasis...
  71. Muthu Periasamy; Fiscal Year: 2016
    ..Studies from our laboratory and others have shown that Sarcolipin (SLN), a regulator of SR Ca2+ ATPase (SERCA), can bind to SERCA in the presence of Ca2+ and promote uncoupling of SERCA and increase ATP hydrolysis...
  72. Deepak Nihalani; Fiscal Year: 2016
    ..identify a novel interaction of Neph1 with Myo1c, a member of the un-conventional Myosin family whose members are ATPase motor proteins that bind to actin and can generate force...
  73. Neurochemical and metabolic regulation in the visual cortex
    MARGARET TT WONG-RILEY; Fiscal Year: 2013
    ..which the same transcription factor, NRF-1, regulates genes for energy generation (COX), energy consumption (Na+K+ATPase), and glutamatergic neurochemicals that mediate excitatory synaptic communication...
  74. Jianyi Zhang; Fiscal Year: 2015
    ..hypothesize that there is transmural gradient of reserves of ATP production rate via both creatine kinase (CK) and ATPase, which is the lowest in ENDO that results in the ENDO vulnerability in LVH hearts...
  75. Alfred L Goldberg; Fiscal Year: 2016
    ..Protein breakdown by the 26S is tightly linked to ATP hydrolysis, and we have shown that the six 19S ATPase subunits hydrolyze ATP in an ordered manner...
  76. Jen Sheen; Fiscal Year: 2016
    ..Partners (HUP1: a scaffolding protein interacting with HXK1, HUP2 and transcription factors (TFs);HUP2: an ATPase interacting with HXK1, HUP1 and other ATPases) in the nucleus to control transcription and diverse glucose ..
  77. Jian Ping Jin; Fiscal Year: 2014
    ..with other thin filament regulatory proteins and its functional impacts on the Ca2+ activation of myofibril ATPase and the contractility of cardiac muscle...
  78. Jerry B Lingrel; Fiscal Year: 2016
    ..Na,K-ATPase activity is dramatically stimulated during muscle contraction and is absolutely required to maintain force and ..
  79. 3D Structure of Membrane Proteins
    Michael Radermacher; Fiscal Year: 2013
    ..The main role of the respiratory chain is the production of a membrane potential used by the F-ATPase for ATP production...
  80. Benjamin D Levine; Fiscal Year: 2016
    ..drug with prominent lusitropic properties due to its ability to upregulate SERCA2a activity;and b) after Na+/K+ ATPase inhibition control (digoxin)...
  81. Paul Forscher; Fiscal Year: 2016
    ..In Aim I will take advantage of the intrinsic ATPase activity of actin filaments and high affinity of active cofilin for ADP-actin subunits to implement an assay for ..
  82. Sanford M Simon; Fiscal Year: 2014
    ..We want to know not just how the machine works, but how its decision tree yields alternative outcomes. ..
  83. James C Alwine; Fiscal Year: 2016
    ..mutational analysis of GRP78 to further understand the role(s) of its functional domains (DNAJ, protein binding, ATPase and the KDEL ER retention signal)(1, 64) in AC formation/localization, lamina phosphorylation/rearrangement and ..
  84. Brittney A Manvilla; Fiscal Year: 2014
    ..In the GET pathway, TA proteins bound to Get3 (an ATPase chaperone), are recruited to a Get1/2 receptor complex in the ER...
  85. Rick Russell; Fiscal Year: 2014
    ..In Aims 1 and 2, we will use simple duplex substrates and an arsenal of experimental approaches to probe how the ATPase cycle is coupled to RNA unwinding and to what extent tethering constrains the position and orientation of the ..
  86. Laurie R Earls; Fiscal Year: 2014
    ..depletion of specific miRNAs (miR-25 and miR-185) which target the expression of the Sarco/endoplasmic reticular ATPase (Serca2), a protein which pumps Ca2+ into the ER...
  87. The Frizzled Nuclear Import Pathway in Synapse Development
    VIVIAN G BUDNIK; Fiscal Year: 2013
    ..Our preliminary studies identify Torsin, a AAA-ATPase, which in humans is linked to early onset dystonia as a key element in the remodeling of nuclear membranes ..
  88. Nephrology Research Training Grant
    Frederic L Coe; Fiscal Year: 2013
    ..glomerular cell injury, function genomics, bioinformatics, epithelial cell growth factors, regulation of Na:K ATPase along the nephron, renal hemodynamics in acute renal failure using direct human clinical protocols, clinical ..
  89. KENNETH R TETER; Fiscal Year: 2016
    ..Most ERAD substrates are extracted from the ER through a mechanism involving the cytosolic AAA ATPase p97. However, p97 appears to play a minimal role in CTA1 translocation...
  90. Todd R Graham; Fiscal Year: 2016
    ..The information obtained will help us understand how human diseases arise from defects in membrane asymmetry or P4-ATPase deficiency.
  91. MICHAEL BYRNE ROBINSON; Fiscal Year: 2015
    ..in individual astrocytes in organotypic slice cultures) that these transporters exst in a complex with the Na+/K+ ATPase, most of the enzymes in glycolysis, and mitochondria. This complex is observed in fine processes of astroglia...
  92. Structural Studies of Vesicular Monoamine Transporters
    SATINDER KAUR SINGH; Fiscal Year: 2013
    ..It works by harnessing a pre-existing proton gradient generated by V-type ATPase to couple the uptake of one cytoplasmic cationic amine with the efflux of two luminal protons...
  93. Michael C Kruer; Fiscal Year: 2016
    ..My own project focuses on ATP13A2 (PARK9), a lysosomal P5B ATPase, and its yeast orthodox ypk9 (yeast PARK9)...
    WILLIAM O BRIEN; Fiscal Year: 2002
    ..We propose that HSV-induced edema results from inhibition of corneal endothelial cell Na+K+ATPase by products of an inducible nitric oxide synthase (NOS)...
  95. MARIA CECILIA CAINO; Fiscal Year: 2015
    ..Since joining the Altieri laboratory, I found that targeting the chaperone ATPase activity of Hsp90s with a small molecule inhibitor selectively engineered to accumulate in mitochondria (..
  96. DAVID MICHAEL MUELLER; Fiscal Year: 2016
    ..In the prior award period, we have solved the high resolution structures of 4 mutant forms of the F1 ATPase and determined the structural basis of mutations in F1 that uncouple proton translocation from ATP synthesis...
  97. Mariusz Karbowski; Fiscal Year: 2015
    ..Furthermore, we also found that AAA- ATPase p97, a critical protein for the endoplasmic reticulum associated degradation (ERAD) pathway, is essential for both ..
  98. Arieh Warshel; Fiscal Year: 2016
    ..ii) Our recent breakthrough in modeling the conversion of pH gradients to vectorial rotation in the F0-ATPase will be quantified, striving to gain a better understanding of the proton paths...
    GENE SCARBOROUGH; Fiscal Year: 2003
    ..A major family of ion-translocating ATPase with about 80 members from all parts of the evolutionary tree is the P-type ATPase family, so named for the ..
  100. High-throughput screen to discover SERCA activators for heart failure therapy
    David D Thomas; Fiscal Year: 2013
    ..A key source of this deficiency is declining activity of the sarcoplasmic reticulum Ca-ATPase (SERCA2a), which is regulated by phospholamban (PLB), a membrane protein that inhibits SERCA...
    Robert Levenson; Fiscal Year: 1992
    The objective of this proposal is to apply the techniques of molecular genetics to the analysis of Na,K-ATPase structure, function and biogenesis...