DMRT3

Summary

Gene Symbol: DMRT3
Description: doublesex and mab-3 related transcription factor 3
Alias: DMRTA3, doublesex- and mab-3-related transcription factor 3, DMRT-like family A3, testis-specific protein
Species: human

Top Publications

  1. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
  2. ncbi Detection and incidence of cryptic Y chromosome sequences in Turner syndrome patients
    P C Patsalis
    Department of Cytogenetics, The Cyprus Institute of Neurology and Genetics, Nicosia
    Clin Genet 53:249-57. 1998
  3. ncbi Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders
    J Dalmau
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain 122:27-39. 1999
  4. doi Gonadoblastoma locus and the TSPY gene on the human Y chromosome
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Birth Defects Res C Embryo Today 87:114-22. 2009
  5. ncbi Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27
    X Shao
    Department of Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Biol Chem 272:6105-13. 1997
  6. ncbi Association of deletion 9p, 46,XY gonadal dysgenesis and autistic spectrum disorder
    G Vinci
    Reproduction, Fertility and Populations, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    Mol Hum Reprod 13:685-9. 2007
  7. pmc Identification of an mRNA-decapping regulator implicated in X-linked mental retardation
    Xinfu Jiao
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Mol Cell 24:713-22. 2006
  8. pmc A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells
    Marcel van Lith
    Department of Biological and Biomedical Sciences, University of Durham, Durham, DH1 3LE, United Kingdom
    Mol Biol Cell 18:2795-804. 2007
  9. ncbi Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene
    J Toshima
    Department of Biology, Faculty of Science, Kyushu University, Hakozaki, Fukuoka 812 81, Japan
    Gene 206:237-45. 1998
  10. pmc The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Hum Pathol 38:1470-81. 2007

Research Grants

  1. Yun Fai Chris Lau; Fiscal Year: 2014
  2. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
  3. A Testis Specific Regulatory Subunit of Protein Phosphatase-1
    Ann O Sperry; Fiscal Year: 2010
  4. Transactivation of Fetal Hemoglobin
    KENNETH PETERSON; Fiscal Year: 2007
  5. RNA SYNTHESIS IN SPERMATOZOA
    NORMAN HECHT; Fiscal Year: 2001
  6. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
  7. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications143 found, 100 shown here

  1. ncbi Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer
    Y F C Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, CA 94121, USA
    Cytogenet Genome Res 101:250-60. 2003
    ....
  2. ncbi Detection and incidence of cryptic Y chromosome sequences in Turner syndrome patients
    P C Patsalis
    Department of Cytogenetics, The Cyprus Institute of Neurology and Genetics, Nicosia
    Clin Genet 53:249-57. 1998
    ..and nested PCR followed by Southern blot analysis of three genes the sex determining region Y (SRY), testis specific protein Y encoded (TSPY) and RNA binding motif protein (RBM) (previously designated as YRRM) and nine additional ..
  3. ncbi Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders
    J Dalmau
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain 122:27-39. 1999
    ..Our study demonstrates that some patients with paraneoplastic neurological disorders develop antibodies against Mal, a new member of an expanding family of 'brain/testis' proteins...
  4. doi Gonadoblastoma locus and the TSPY gene on the human Y chromosome
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, California 94121, USA
    Birth Defects Res C Embryo Today 87:114-22. 2009
    ....
  5. ncbi Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27
    X Shao
    Department of Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Biol Chem 272:6105-13. 1997
    ..The use of the yeast screening approach to isolate leucine zipper containing proteins should be useful in other systems, and our findings have implications for ODF structural models...
  6. ncbi Association of deletion 9p, 46,XY gonadal dysgenesis and autistic spectrum disorder
    G Vinci
    Reproduction, Fertility and Populations, Institut Pasteur, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
    Mol Hum Reprod 13:685-9. 2007
    ..The deletion included the candidate sex-determining genes in the region DMRT1 and DMRT3. These data suggest that a gene responsible for autistic spectrum disorder is located within 9p24...
  7. pmc Identification of an mRNA-decapping regulator implicated in X-linked mental retardation
    Xinfu Jiao
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Mol Cell 24:713-22. 2006
    ..Its cap association is enhanced by hDcp2 to further augment the ability of VCX-A to inhibit decapping. Our data demonstrate that VCX-A can regulate mRNA stability and that it is an example of a tissue-specific decapping regulator...
  8. pmc A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells
    Marcel van Lith
    Department of Biological and Biomedical Sciences, University of Durham, Durham, DH1 3LE, United Kingdom
    Mol Biol Cell 18:2795-804. 2007
    ..The identification of a redox-inactive chaperone partnership defines a new system of testis-specific protein folding with implications for male fertility...
  9. ncbi Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene
    J Toshima
    Department of Biology, Faculty of Science, Kyushu University, Hakozaki, Fukuoka 812 81, Japan
    Gene 206:237-45. 1998
    ..The Tesk1 gene was mapped to mouse chromosome 4A5-C1 by fluorescence in situ hybridization...
  10. pmc The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Hum Pathol 38:1470-81. 2007
    ..Our results suggest that TSPY, in combination with other markers, could be an important marker for diagnosis and subclassification of TGCTs and support its role in the pathogenesis of both gonadoblastoma and TGCTs...
  11. ncbi Cloning and chromosomal localization of a gene encoding a novel serine/threonine kinase belonging to the subfamily of testis-specific kinases
    P E Visconti
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania, 19104 6142, USA
    Genomics 77:163-70. 2001
    ..Fluorescence in situ hybridization with both the human and mouse cDNA clones revealed syntenic localization on chromosomes 1p34-p35 and 4E1, respectively...
  12. ncbi Molecular characterization of the equine testis-specific protein 1 (TPX1) and acidic epididymal glycoprotein 2 (AEG2) genes encoding members of the cysteine-rich secretory protein (CRISP) family
    Alexander Giese
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    Gene 299:101-9. 2002
    ..Comparative genome analysis between horse, human, and mouse indicates that all three CRISP genes are clustered on one chromosomal location, which shows conserved synteny between these species...
  13. ncbi Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad
    Shinseog Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Gene Expr Patterns 3:77-82. 2003
    ..to Dmrt1 are expressed in the embryonic gonad: Dmrt4 is expressed at similar levels in gonads of both sexes; Dmrt3 is more highly expressed in males; and Dmrt7 is more highly expressed in females...
  14. ncbi Expression and function of the HSD-3.8 gene encoding a testis-specific protein
    W Lin
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 5 Dong Dan 3 Tiao, Beijing 100005, People s Republic of China
    Mol Hum Reprod 7:811-8. 2001
    ..8 is a GTP binding protein. It was also shown to possess GTPase activity and to be phosphorylated by PKC in vitro. In conclusion, HSD-3.8 is a GTP binding protein and its activity may be regulated by phosphorylation...
  15. ncbi A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion
    Blanca E Galindo
    Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093 0202, USA
    Dev Growth Differ 46:53-60. 2004
    ..In the present study, we describe the sequence, domain structure and localization of suREJ2 and speculate on its possible function...
  16. ncbi Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"
    T Vogel
    Institute of Human Genetics, Medizinische Hochschule Hannover, Germany
    Cytogenet Cell Genet 80:209-13. 1998
    ..The TSPY family forms part of a superfamily, TTSN, with autosomal representatives, highly conserved in mammals and beyond...
  17. ncbi Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute and Department of Paediatrics, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Mech Dev 119:S73-6. 2002
    ..It is shown here that the recently identified gene, DMRT3, has a restricted embryonic expression profile that is conserved in chicken and mouse embryos...
  18. ncbi RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin
    T Rich
    Preuss Laboratory for Molecular Neuro Oncology, Department of Neurological Surgery, School of Medicine, University of California San Francisco 94143 0520, USA
    Gene 180:125-30. 1996
    ..Multiple mRNAs encoded by RTVP-1 were highly expressed in a panel of cell lines from nervous system tumors arising from glia, although expression was low or absent in nonglial-derived nervous system tumor cell lines...
  19. ncbi Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loop
    J Toshima
    Department of Biology, Faculty of Science, Kyushu University, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Biol Chem 274:12171-6. 1999
    ..These results suggest that autophosphorylation of Ser-215 is an important step to positively regulate the kinase activity of TESK1...
  20. ncbi Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma
    Y Lau
    Department of Medicine, VA Medical Center, University of California, San Francisco CA, USA
    Cytogenet Cell Genet 91:160-4. 2000
    ..The present observations suggest that TSPY may either be involved in the oncogenesis of or be a useful marker for both types of germ cell tumors...
  21. ncbi CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation
    Soren Naaby-Hansen
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, W1P 8BT, United Kingdom
    Dev Biol 242:236-54. 2002
    ..CABYR localizes to the principal piece of the human sperm flagellum in association with the fibrous sheath and is the first demonstration of a sperm protein that gains calcium-binding capacity when phosphorylated during capacitation...
  22. ncbi A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications
    Hui Wang
    Key Laboratory of Reproductive Medicine, Nanjing Medical University, 210029 Nanjing, Jiangsu Province, China
    J Mol Med (Berl) 82:317-24. 2004
    ....
  23. pmc TSPY is a cancer testis antigen expressed in human hepatocellular carcinoma
    Y H Yin
    Immunology Department, Peking University Health Science Center, Beijing, China
    Br J Cancer 93:458-63. 2005
    ..In conclusion, these data suggest that TSPY is a novel cancer/testis (CT) antigen and may be a potential candidate in vaccine strategy for immunotherapy in HCC patients...
  24. ncbi Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility
    Yong Du
    Department of Histology and Embryology, Nanjing Medical University, Nanjing, People s Republic of China
    Fertil Steril 85:1852-4. 2006
    Human testis specific protein 1 (TPX1) exists in the cytomembrane and cytoplasm of spermatogenic cells from pachytene spermatocytes to elongated spermtids, including pachytene spermatocytes, round spermtids and elongated spermtids...
  25. ncbi Polypyrimidine tract binding protein 2 stabilizes phosphoglycerate kinase 2 mRNA in murine male germ cells by binding to its 3'UTR
    Mingang Xu
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104 6080, USA
    Biol Reprod 76:1025-33. 2007
    ..We propose that PTBP2 is a trans-acting factor that helps to stabilize Pgk2 mRNA in male mouse germ cells...
  26. ncbi Tumor risk in disorders of sex development (DSD)
    Leendert H J Looijenga
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Josephine Nefkens Institute, Building Be, Room 430b, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 21:480-95. 2007
    ....
  27. pmc Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton
    Cindy Johne
    Max Planck Unit for Structural Molecular Biology, D 22607 Hamburg, Germany
    Mol Biol Cell 19:1391-403. 2008
    ..Thus, the three-way interaction between Spred1, MARKK, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton...
  28. doi The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Cancer 123:1573-85. 2008
    ..Our results suggest that TSPY could exert its oncogenic function(s) by interacting with eEF1As and stimulating gene expression via its enhancements in protein synthesis and gene transcription...
  29. pmc Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
    Toru Sasaki
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, Ontario M5G2C1, Canada
    J Cell Biol 182:449-58. 2008
    ..Inhibition of proteasomal degradation restores Hsp70-2 protein levels. Our findings identify Bat3 as a critical regulator of Hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility...
  30. ncbi Transcriptome analysis of hepatitis B virus-associated small hepatocellular carcinoma by serial analysis of gene expression
    Jin Wook Kim
    Department of Medicine, Seoul National University Bundang Hospital, Bundang gu, Seongnam 463 802, Korea
    Int J Oncol 35:129-37. 2009
    ..The significance of these genes with respect to carcinogenesis and early diagnosis of HCC needs to be elucidated in further studies...
  31. doi Spats 1 (Srsp1) is differentially expressed during testis development of the rat
    Carlos A Capoano
    Department of Biología Molecular, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, Uruguay
    Gene Expr Patterns 10:1-8. 2010
    ..Moreover, we show that the protein is highly conserved along metazoan evolution. Our results suggest a role in the initiation of the first spermatogenic wave, and in the establishment or progression of the first male meiotic division...
  32. doi Tumor risk in disorders of sex development
    J Pleskacova
    Department of Pediatrics, Charles University, 2nd Faculty of Medicine, Prague, Czech Republic
    Sex Dev 4:259-69. 2010
    ..8% and 2.6% of cases, respectively. However, these data may be biased for various reasons. To better estimate the risk in individual groups of DSD, further investigations on large patient series are needed...
  33. doi Role of the Y-located putative gonadoblastoma gene in human spermatogenesis
    Yun Fai Chris Lau
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Syst Biol Reprod Med 57:27-34. 2011
    ....
  34. pmc TSPYL2 is important for G1 checkpoint maintenance upon DNA damage
    Kin Pong Tao
    Department of Paediatrics and Adolescent Medicine, Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    PLoS ONE 6:e21602. 2011
    ..b>Testis specific protein, Y-encoded-like 2 (TSPYL2) is a nucleosome assembly protein expressed in neuronal precursors and mature ..
  35. pmc Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus
    Kerstin Hasenpusch-Theil
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Cereb Cortex 22:2878-93. 2012
    ..conserved Tcf/Lef-binding sites in telencephalon-specific enhancers of several of these genes, including Dmrt3, Gli3, Nfia, and Wnt8b. Binding of Lef1 to these sites was confirmed using electrophoretic mobility shift assays...
  36. pmc Genome-wide analysis reveals selection for important traits in domestic horse breeds
    Jessica L Petersen
    College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA
    PLoS Genet 9:e1003211. 2013
    ..The recent identification of a DMRT3 mutation within this haplotype, which appears necessary for the ability to perform alternative gaits, provides ..
  37. doi The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma
    Tatsuo Kido
    Department of Medicine, Veterans Affairs Medical Center, San Francisco, CA, 94121, USA Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94121, USA
    Hum Pathol 45:1847-58. 2014
    ....
  38. pmc Spermitin: a novel mitochondrial protein in Drosophila spermatids
    Jieyan V Chen
    Department of Biomedical Sciences, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 9:e108802. 2014
    ..The role of Sprn is unclear, as sprn mutant males are fertile, and have sperm tail length comparable to the wild-type. ..
  39. doi [Research progress of TSPY1 gene family]
    Ying Shen
    Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 31:600-3. 2014
    ..In this review, the structure characteristics of the gene family were illustrated, and the functional studies of TSPY1 in the process of tumorigenesis and spermatogenesis were discussed. ..
  40. pmc Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents
    Alberto Vicens
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006, Madrid, Spain
    Mol Hum Reprod 21:146-56. 2015
    ....
  41. pmc Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice
    Qi Li
    Department of Psychiatry, The University of Hong Kong, Hong Kong SAR, China
    Behav Genet 46:529-37. 2016
    b>Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors...
  42. doi Quantitative analysis of short- and long-distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses
    S Negro Rama
    Department of Agroforestry Sciences, ETSIA, University of Seville, Seville, Spain
    J Anim Breed Genet 133:347-56. 2016
    ..with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes...
  43. ncbi [Study on the function of HSD-3.8 gene encoding a testis-specific protein with yeast two-hybrid system]
    Wen Lin
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS, PUMC, Beijing 100005, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:582-7. 2002
    ..To explore the protein factors that could interact with the testis-specific protein encoded by HSD-3.8 gene (GenBank Accession Number AF311312) related with female fertilization...
  44. ncbi Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation
    Gerold Untergasser
    Austrian Academy of Sciences, Institute for Biomedical Aging Research, Rennweg 10, Innsbruck A 6020, Austria
    Mech Ageing Dev 126:59-69. 2005
    ..Genes such as GageC1 could be promising targets for therapeutic inhibitors of stromal tissue remodeling and progression of BPH and PCa...
  45. ncbi Identification of the testis-specific protein 10 (TSGA10) as serologically defined tumour-associated antigen in primary cutaneous T-cell lymphoma
    S M Theinert
    Department of Dermatology, Venereology and Allergy, Charite Universitaetsmedizin Berlin, Humboldt University, D 10098 Berlin, Germany
    Br J Dermatol 153:639-41. 2005
    ....
  46. ncbi Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma
    Mei Tsz Su
    Department of Obstetrics and Gynecology, National Cheng Kung University Medical Center, 138 Sheng Li Road, Tainan 704, Taiwan
    Gynecol Oncol 103:357-60. 2006
    ..Testis-specific protein Y-encoded (TSPY) gene may participate in the oncogenesis of gonadoblastoma expression of TSPY in the tumor tissue. This might suggest TSPY as a candidate gene for gonadoblastoma...
  47. pmc Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
    Lisa S Andersson
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE 75124 Uppsala, Sweden
    Nature 488:642-6. 2012
    ..Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses...
  48. doi Dmrta1 regulates proneural gene expression downstream of Pax6 in the mammalian telencephalon
    Takako Kikkawa
    Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Genes Cells 18:636-49. 2013
    ..We found that another Dmrt family molecule, Dmrt3, induced Neurog2 expression in the dorsal telencephalon...
  49. ncbi X-chromosomal localization of mammalian Y-linked genes in two XO species of the Ryukyu spiny rat
    Y Arakawa
    Laboratory of Ecology and Genetics, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    Cytogenet Genome Res 99:303-9. 2002
    ....
  50. ncbi [Advances in the research of sperm protein 17]
    Ling Zhang
    Center of Medical Laboratory Science of PLA, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China
    Zhonghua Nan Ke Xue 10:295-7, 301. 2004
    ..This paper reviews the advances in the protein characterization, expression and distribution, and biological function of Sp17 and its clinical research...
  51. ncbi Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells
    Friedemann Honecker
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Pathol 203:849-57. 2004
    ..These findings are compatible with the hypothesis that CIS/ITGCNU arises from developmentally arrested germ cells, most likely primordial germ cells/gonocytes, at an early time point during intrauterine development...
  52. ncbi Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors
    Martine Cools
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Daniel den Hoed, 3000 DR Rotterdam, The Netherlands
    Hum Pathol 37:101-11. 2006
    ....
  53. ncbi Mice overexpression of human augmenter of liver regeneration (hALR) in male germ cells shows abnormal spermatogenesis and reduced fertility
    Yan Cao
    Beijing Institute of Radiation Medicine, Beijing, China
    Endocr J 59:989-99. 2012
    ..Present findings in the mouse may be of interest to human male fertility...
  54. pmc Foxg1 coordinates the switch from nonradially to radially migrating glutamatergic subtypes in the neocortex through spatiotemporal repression
    Takuma Kumamoto
    Laboratory for Neocortical Development, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Rep 3:931-45. 2013
    ..noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including Ebf2/3, Dmrt3, Dmrta1, and Eya2...
  55. ncbi Refinement of the localization of the gene for human intraacrosomal protein SP-10 (ACRV1) to the junction of bands q23-->q24 of chromosome 11 by nonisotopic in situ hybridization
    W L Golden
    Department of Pediatrics, University of Virginia, Charlottesville 22908
    Genomics 18:446-9. 1993
    ..This report emphasizes the utility of riboprobes for chromosome localization of single-copy genes...
  56. ncbi Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues
    F Schnieders
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Hum Mol Genet 5:1801-7. 1996
    ..The data presented here point to a phosphorylation-dependent TSPY-function in early spermatogenesis, immediately prior to the spermatogonia-to-spermatocyte transition, and in early testicular tumorigenesis...
  57. ncbi Supernumerary marker chromosomes (SMCs) in Turner syndrome are mostly derived from the Y chromosome
    P C Patsalis
    Department of Cytogenetics, Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Clin Genet 51:184-90. 1997
    ..The Sex determining Region Y (SRY), Testis Specific Protein Y-encoded (TSPY) and Y-chromosome RNA Recognition Motif (YRRM) genes, which map at Yp11.31, Yp11.1-11...
  58. ncbi Cloning of a novel testis specific protein serine/threonine phosphatase, PPN 58A, from Drosophila melanogaster
    C G Armstrong
    Department of Biochemistry, University of Dundee, UK
    Biochim Biophys Acta 1399:234-8. 1998
    ..melanogaster PPY 55A and < or = 40% identity to other members of the PPP family. The single copy gene PPN 58A maps to chromosome 2 locus 58A. Analysis of PPN 58A mRNA reveals that, like PPY 55A, PPN 58A is a testis specific enzyme...
  59. pmc Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila
    S R Martin
    Division of Physical Biochemistry, National Institute for Medical Research, Mill Hill, London, United Kingdom
    Protein Sci 8:2444-54. 1999
    ....
  60. ncbi Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa
    V A Westbrook
    Departments of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 63:469-81. 2000
    ..Expression of SPAN-X, an X-linked gene product, exclusively in haploid spermatids leads to interesting questions regarding the transcription of sex-linked genes during spermiogenesis...
  61. ncbi VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A
    Elaine Y M Wong
    Department of Obstetrics and Gynaecology, The University of Hong Kong, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam Road, Hong Kong
    Biochem Biophys Res Commun 296:1104-11. 2002
    ..These data suggest that UBE3A ubiquitination may be required for VCY2 function...
  62. ncbi Restricted expression of DMRT3 in chicken and mouse embryos
    Craig A Smith
    Murdoch Children s Research Institute, The University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    Gene Expr Patterns 2:69-72. 2002
    ..It is shown here that the recently identified gene, DMRT3, has a restricted embryonic expression profile that is conserved in chicken and mouse embryos...
  63. ncbi Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein
    Elaine Y M Wong
    Department of Obstetrics and Gynaecology, University of Hong Kong, China
    Biol Reprod 70:775-84. 2004
    ..Our expression data support the involvement of VCY2 and VCY2IP-1 in spermatogenesis. Based on the high homology of VCY2IP-1 with MAPs, we propose the involvement of VCY2 in the cytoskeletal network via interaction with VCY2IP-1...
  64. ncbi Developmentally regulated and non-sex-specific expression of autosomal dmrt genes in embryos of the Medaka fish (Oryzias latipes)
    Christoph Winkler
    Department of Physiological Chemistry I, Biocenter, University of Wuerzburg, Wuerzburg, Germany
    Mech Dev 121:997-1005. 2004
    ..On the other hand, dmrt2, dmrt3 and dmrt4 show highly restricted and non-overlapping expression patterns during embryogenesis...
  65. ncbi PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum
    Marcel van Lith
    Department of Biological Sciences, University of Durham, Durham, DH1 3LE, United Kingdom
    J Biol Chem 280:1376-83. 2005
    ..PDILT is an unusual PDI relative that highlights the adaptability of chaperone and redox function in enzymes of the endoplasmic reticulum...
  66. ncbi Organization and concerted evolution of the ampliconic Y-chromosomal TSPY genes from cattle
    Edward L C Verkaar
    Faculty of Veterinary Medicine, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    Genomics 84:468-74. 2004
    ..A comparison of TSPY-M1 sequences from different BAC clones and from related bovine species suggests concerted evolution as one of the mechanisms of the rapid evolution of the mammalian Y chromosome...
  67. ncbi CK2-dependent C-terminal phosphorylation at T300 directs the nuclear transport of TSPY protein
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Frankfurt am Main, Germany
    Biochem Biophys Res Commun 341:343-50. 2006
    ..We conclude that phosphorylation of the (T300) residue is a necessary and functional prerequisite for TSPY's transport into the nucleus reminding of comparable data from a related Drosophila molecule, NAP1...
  68. ncbi DMRT gene cluster analysis in the platypus: new insights into genomic organization and regulatory regions
    Nisrine El-Mogharbel
    Comparative Genomics Group, Research School of Biological Sciences, Australian National University, P O Box 475, Canberra, ACT 2601, Australia
    Genomics 89:10-21. 2007
    ..The DMRT gene cluster on human 9p24.3 harbors, in order, DMRT1, DMRT3, and DMRT2, which share a DM domain...
  69. ncbi Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ
    Yunmin Li
    Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA
    Urol Oncol 25:141-6. 2007
    ..These findings support the candidacy of TSPY as the gene for the gonadoblastoma locus on Y chromosome and suggest that TSPY could be a significant marker for these types of germ cell tumors...
  70. ncbi Testis-expressed protein TSGA10 an auto-antigen in autoimmune polyendocrine syndrome type I
    Koit Reimand
    Immunology and Molecular Pathology Groups, Centre of Molecular and Clinical Medicine, University of Tartu, 19 Ravila Street, Tartu 50411, Estonia
    Int Immunol 20:39-44. 2008
    ..Nevertheless, their presence in a proportion of patients with APS1 highlights the role of TSGA10 as a target of immune reactions in APS1...
  71. ncbi Importance of the porcine ADAM3 disintegrin domain in sperm-egg interaction
    Ekyune Kim
    National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chung buk, Korea
    J Reprod Dev 55:156-62. 2009
    ..In the present study, we demonstrated the presence of ADAM3a and ADAM3b molecules in the pig and examined their roles in fertilization...
  72. doi The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers
    Daiji Oka
    Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 115:3412-26. 2009
    ..In this study, the objective was to elucidate the effects of smoking and drinking on the accumulation of epigenetic alterations in background mucosae...
  73. doi Cell-free DNA as a noninvasive acute rejection marker in renal transplantation
    Vanessa García Moreira
    Biochemistry Laboratory and Nephrology and Bone Metabolism Unit, Hospital Universitario Central de Asturias, Asturias, Spain
    Clin Chem 55:1958-66. 2009
    ..We assessed whether total cell-free DNA (tCF-DNA) and donor-derived cell-free DNA (ddCF-DNA) were useful markers for this purpose, both in plasma and in urine...
  74. doi Y chromosome TSPY copy numbers and semen quality
    Bita Nickkholgh
    Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Fertil Steril 94:1744-7. 2010
    ..To determine whether variation in testis-specific protein Y-encoded (TSPY) gene copy number affects semen quality...
  75. doi Macroscopic sertoli cell nodule: a study of 6 cases that presented as testicular masses
    Bethany D Vallangeon
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Clarian Pathology Laboratory, Indianapolis, IN, USA
    Am J Surg Pathol 34:1874-80. 2010
    ..We conclude that Sertoli cell nodules may present clinically as mass lesions, and that it is important to distinguish them from true neoplasms to avoid unnecessary procedures...
  76. doi Inv dup del(9p): prenatal diagnosis and molecular cytogenetic characterization by fluorescence in situ hybridization and array comparative genomic hybridization
    Chih Ping Chen
    Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    Taiwan J Obstet Gynecol 50:67-73. 2011
    ..To present molecular cytogenetic characterization of prenatally detected inverted duplication and deletion of 9p, or inv dup del(9p)...
  77. doi Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy
    Maurizio Chiriva-Internati
    Division of Hematology and Oncology, Texas Tech University Health Sciences Center and the Southwest Cancer Treatment and Research Center, Lubbock, TX 79430, USA
    J Immunother 34:490-9. 2011
    ..We suggest that ropporin is a promising target for MM immunotherapy, as we were able to generate human leukocyte antigen class I-restricted cytotoxic lymphocytes able to kill autologous MM cells...
  78. doi Sexing single bovine blastomeres using TSPY gene amplification
    M C A Carneiro
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Genet Mol Res 10:3937-41. 2011
    ..This is the first report to demonstrate the applicability of the TSPY gene for sexing single cells in cattle...
  79. pmc Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]
    Keizo Tokuhiro
    Research Institute for Microbial Diseases, University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 109:3850-5. 2012
    ..Moreover, the importance of primary sperm ZP binding, which has been thought to be a critical step in mammalian fertilization, should be reconsidered...
  80. ncbi Molecular isolation and characterization of an expressed gene from the human Y chromosome
    J S Zhang
    Division of Cell and Developmental Genetics, VA Medical Center, University of California, San Francisco 94121
    Hum Mol Genet 1:717-26. 1992
    ..Y-231 gene shares very high (97%) identity at the DNA level to a previously described Y-specific gene, testis specific protein Y-encoded (TSPY) gene, suggesting the possibility that these two genes are related, if not identical...
  81. ncbi Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY
    J Arnemann
    National Institute for Medical Research, Laboratory of Eukaryotic Molecular Genetics, London, United Kingdom
    Genomics 11:108-14. 1991
    ..PCR analysis of genomic DNA from patients with specific primers confirmed the simultaneous presence of at least two independent loci on the proximal short arm of the Y chromosome...
  82. ncbi TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome
    E Manz
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:726-31. 1993
    ..Transcript variability is not restricted to single basepair exchanges. We present data for the existence of at least three differently sized TSPY transcripts, caused by different patterns of splicing...
  83. ncbi A bovine homologue of the human TSPY gene
    S Jakubiczka
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:732-5. 1993
    ..The clone isolated from the bovine genome has two regions that are highly conserved between homo and bos. One stretch of DNA is homologous in 45 of 51 bp (88%), and the other stretch shares 71 of 100 bp (71%)...
  84. ncbi Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells
    J Toshima
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    J Biol Chem 270:31331-7. 1995
    ..The TESK1 mRNA in the testis was detectable only after the 18th day of postnatal development of mice and was mainly expressed in the round spermatids. These observations suggest that TESK1 has a specific function in spermatogenesis...
  85. ncbi [Analysis of the human acidic epididymal glycoprotein-like molecule: isolation of cDNA and tissue localization]
    M Hayashi
    Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan
    Hokkaido Igaku Zasshi 70:743-53. 1995
    ..Immunohistochemical analysis showed that the human AEG-like molecule is located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head...
  86. ncbi Drosophila PPY, a novel male specific protein serine/threonine phosphatase localised in somatic cells of the testis
    C G Armstrong
    Department of Biochemistry, University, Dundee, Scotland, UK
    J Cell Sci 108:3367-75. 1995
    ..We also demonstrate that PPY is a novel testis specific protein phosphatase by analysis of both mRNA and protein distribution...
  87. ncbi A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny
    H S Kim
    Department of Cellular and Molecular Biology, Kyoto University, Aichi, Japan
    Am J Phys Anthropol 100:301-9. 1996
    ..024, 0.048, and 0.094, respectively. The rates of nucleotide substitutions per site per year were higher in the TSPY intron than in the TSPY exon, and higher in the TSPY intron than in the ZFY (Zinc Finger Y) intron in human and apes...
  88. ncbi Autoantigen 1 of the guinea pig sperm acrosome is the homologue of mouse Tpx-1 and human TPX1 and is a member of the cysteine-rich secretory protein (CRISP) family
    J A Foster
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104 6080, USA
    Mol Reprod Dev 44:221-9. 1996
    ..Thus, the patterns of AA1 mRNA and protein expression during spermatogenesis are similar to the expression of other acrosomal mRNAs and proteins that are first detected meiotically...
  89. ncbi Mechanism of infertility in male guinea pigs immunized with sperm PH-20
    K S Tung
    Department of Pathology and Microbiology, University of Virginia, Charlottesville 22908, USA
    Biol Reprod 56:1133-41. 1997
    ..Return to fertility, after 6-12 mo, was accompanied by regression of EAO and reappearance of spermatozoa in the caudae epididymides...
  90. ncbi Organization and expression of bovine TSPY
    T Vogel
    Institut fur Humangenetik, Medizinische Hochschule Hannover, D 30623 Hannover, Germany
    Mamm Genome 8:491-6. 1997
    ..Comparison with the human homolog shows the highest degree of similarity in the coding regions of exons 2, 3, and 4, which are also precisely conserved regarding their length...
  91. ncbi Novel testis-specific protein-DNA interactions activate transcription of the mouse protamine 2 gene during spermatogenesis
    G K Yiu
    Department of Biology, Tufts University, Medford, Massachusetts 02155, USA
    J Biol Chem 272:26926-33. 1997
    ..These data suggest that the testis-specific PAF-1 and a Y-box-binding protein are needed to activate mP2 transcription in postmeiotic male germ cells...
  92. ncbi Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators
    T C Tseng
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC
    DNA Cell Biol 17:823-33. 1998
    ..The kinase activity of AIE1 can be destroyed by heat inactivation. In summary, we suggest that AIE is a new member of the S/T kinase family, which may be regulated in a fashion distinct from other AIE-related kinases...
  93. ncbi Gene structure of rat testicular cell adhesion molecule 1 (TCAM-1), and its physical linkage to genes coding for the growth hormone and BAF60b, a component of SWI/SNF complexes
    M Ono
    Department of Molecular Biology, School of Medicine, Kitasato University, Sagamihara, Kanagawa 228 8555, Japan
    Gene 226:95-102. 1999
    ..Six genes were thus mapped in the following order in the 88kb region of the rat GH locus: Na-channel (5' to 3')-B29/Ig-beta (5' to 3')-GH (5' to 3')-TCAM-1 (3' to 5')-BAF60b (5' to 3')-SUG/p45 (3' to 5')...
  94. pmc A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype
    R Slee
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland
    Proc Natl Acad Sci U S A 96:8040-5. 1999
    ....
  95. ncbi The region on 9p associated with 46,XY sex reversal contains several transcripts expressed in the urogenital system and a novel doublesex-related domain
    C Ottolenghi
    Unité d Immunogénétique Humaine, INSERM U276, Institut Pasteur, 25 rue du Docteur Roux, Paris, 75724, France
    Genomics 64:170-8. 2000
    ..Future investigations will include functional and mutational studies of the novel transcripts mapped or sublocalized within the critical region by this study as well as cloning efforts to isolate additional candidate genes...
  96. ncbi Identification of a novel testis-specific leucine-rich protein in humans and mice
    J C Xue
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 62:1278-84. 2000
    ..Immunohistochemical localization is markedly reduced in secondary spermatocytes, suggesting a functional association of LRTP with meiosis. An LRTP cDNA probe did not bind to mouse ovary RNA in a dot blot assay...
  97. ncbi The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family
    M Guipponi
    Division of Medical Genetics, University of Geneva Medical School, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Hum Genet 109:569-75. 2001
    ..The Y chromosome copy of TPTE is a pseudogene and is not therefore involved in the testis expression of this gene family...
  98. ncbi Atce1: a novel mouse cyclic adenosine 3',5'-monophosphate-responsive element-binding protein-like gene exclusively expressed in postmeiotic spermatids
    Gil Stelzer
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Endocrinology 143:1578-88. 2002
    ..Interestingly, EMSAs revealed that in vitro translated Atce1 binds specifically to a nuclear factor-kappaB-binding element rather then to a CRE element. Potential roles for Atce1 are discussed...
  99. ncbi The gene TSGA14, adjacent to the imprinted gene MEST, escapes genomic imprinting
    Takahiro Yamada
    Department of Human Genetics, Nagasaki University School of Medicine, Japan
    Gene 288:57-63. 2002
    ..The fact that COPG2 and TSGA14, both neighbors of MEST, escape genomic imprinting suggests that the 7q32 imprinted region may be small and not similar to other imprinted domains, such as those at 15q11-13 and 11p15.5...
  100. ncbi Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22
    Zaohua Huang
    Biological Sciences Department, Kent State University, Ohio 44242, USA
    Biol Reprod 67:1936-42. 2002
    ..Mechanisms regulating sds22 binding to PP1gamma2 are likely to be important in understanding the biochemical basis underlying development and regulation of sperm function...
  101. ncbi Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes
    Roswitha Krick
    Institute of Human Genetics, Johann Wolfgang Goethe University Hospital, Theodor Stern Kai 7 Haus 9, D 60590, Frankfurt am Main, Germany
    Gene 302:11-9. 2003
    b>Testis specific protein (TSPY) is a human Y-chromosome derived gene with numerous functional and non-functional copies...

Research Grants7

  1. Yun Fai Chris Lau; Fiscal Year: 2014
    ..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
  2. Transactivation of Fetal Hemoglobin
    Kenneth R Peterson; Fiscal Year: 2011
    ....
  3. A Testis Specific Regulatory Subunit of Protein Phosphatase-1
    Ann O Sperry; Fiscal Year: 2010
    ..This research will examine the importance of a testis-specific regulatory protein in spermatogenesis and will provide insight into possible remedies for male infertility as well as possible strategies for contraceptive design. ..
  4. Transactivation of Fetal Hemoglobin
    KENNETH PETERSON; Fiscal Year: 2007
    ..This proposal will generate unique tools and new strategies to understand mechanisms of ?-globin gene regulation for treatment of SCD. ..
  5. RNA SYNTHESIS IN SPERMATOZOA
    NORMAN HECHT; Fiscal Year: 2001
    ..a ubiquitous mitochondrial protein is replaced at a specific stage of male germ cell differentiation by a testis specific protein variant and whether this coordinate regulation of gene expression is a prerequisite for normal ..
  6. FUNCTIONS OF SRY AND SRY INTERACTIVE PROTEIN GENES
    Yun Fai Chris Lau; Fiscal Year: 2004
    ..Understanding the mechanisms of sex determination in mouse may shed insights on those in humans, and eventually may lead to developments of clinical diagnosis and treatment of gonadal dysgenesis and infertility. ..
  7. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..