DLK1

Summary

Gene Symbol: DLK1
Description: delta like non-canonical Notch ligand 1
Alias: DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, protein delta homolog 1, delta-like 1 homolog, fetal antigen 1, preadipocyte factor 1, secredeltin
Species: human

Top Publications

  1. pmc Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region
    M Paulsen
    University of Cambridge, Department of Anatomy, Cambridge CB2 3DY, United Kingdom
    Genome Res 11:2085-94. 2001
  2. ncbi Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Carcinogenesis 28:1094-103. 2007
  3. ncbi Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
    Shau Ping Lin
    Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK
    Development 134:417-26. 2007
  4. doi Genomic imprinting at the mammalian Dlk1-Dio3 domain
    Simao Teixeira da Rocha
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Trends Genet 24:306-16. 2008
  5. ncbi Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2
    C H Jensen
    Division of Immunology, Statens Seruminstitut, Copenhagen S, Denmark
    Eur J Biochem 225:83-92. 1994
  6. ncbi Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
    C M Smas
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115
    Cell 73:725-34. 1993
  7. ncbi FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression
    D Tornehave
    Department of Molecular Cell Biology, Statens Seruminstitut, Copenhagen, Denmark
    Histochem Cell Biol 106:535-42. 1996
  8. ncbi Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3
    S Kobayashi
    Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Genes Cells 5:1029-37. 2000
  9. pmc Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals
    Brad A Freking
    U S Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, Nebraska 68933 0166, USA
    Genome Res 12:1496-506. 2002
  10. ncbi High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type
    Vera A E Van Limpt
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 105:61-9. 2003

Research Grants

  1. Protease Inhibitor Related Adipogenesis in HIV Infection
    Krishna Agrawal; Fiscal Year: 2003
  2. Molecular Pathology in Polycystic Kidney Disease
    Jing Zhou; Fiscal Year: 2010
  3. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
  4. The Role of Foxa2 in Metabolism
    Markus Stoffel; Fiscal Year: 2006
  5. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2003
  6. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2013
  7. Obesity and deregulation of imprinted genes in early life
    Susan Kay Murphy; Fiscal Year: 2013
  8. Pref-1 function and regulation in adipogenesis
    Hei Sook Sul; Fiscal Year: 2013
  9. Eva E Redei; Fiscal Year: 2014
  10. Meifan Chen; Fiscal Year: 2015

Detail Information

Publications227 found, 100 shown here

  1. pmc Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region
    M Paulsen
    University of Cambridge, Department of Anatomy, Cambridge CB2 3DY, United Kingdom
    Genome Res 11:2085-94. 2001
    The Dlk1-Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control...
  2. ncbi Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Carcinogenesis 28:1094-103. 2007
    ..Dysregulation of a genomic imprinting gene can contribute to carcinogenesis. Here, delta-like 1 homolog (Drosophila) (DLK1), a paternally expressed gene, was found to be significantly up-regulated in 60 (73...
  3. ncbi Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
    Shau Ping Lin
    Department of Physiology, Development and Neuroscience, University of Cambridge, Anatomy Building, Downing Street, Cambridge CB2 3DY, UK
    Development 134:417-26. 2007
    ..This indicates that the mechanism of action of the IG-DMR is different in the embryo and the placenta and suggests that the epigenetic control of imprinting differs in these two lineages...
  4. doi Genomic imprinting at the mammalian Dlk1-Dio3 domain
    Simao Teixeira da Rocha
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Trends Genet 24:306-16. 2008
    ..of imprinted genes delineated by the delta-like homolog 1 gene and the type III iodothyronine deiodinase gene (Dlk1-Dio3) is located on distal mouse chromosome 12 and human chromosome 14...
  5. ncbi Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2
    C H Jensen
    Division of Immunology, Statens Seruminstitut, Copenhagen S, Denmark
    Eur J Biochem 225:83-92. 1994
    The present paper describes the primary structure, glycosylation and tissue localization of fetal antigen 1 (FA1) isolated from second-trimester human amniotic fluid...
  6. ncbi Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
    C M Smas
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115
    Cell 73:725-34. 1993
    With the aim of identifying novel regulators of adipocyte differentiation, we have cloned and characterized preadipocyte factor 1 (pref-1), a novel member of the epidermal growth factor (EGF)-like family of proteins...
  7. ncbi FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression
    D Tornehave
    Department of Molecular Cell Biology, Statens Seruminstitut, Copenhagen, Denmark
    Histochem Cell Biol 106:535-42. 1996
    b>Fetal antigen 1 (FA1) is a glycoprotein containing six epidermal growth factor (EGF)-like repeats...
  8. ncbi Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3
    S Kobayashi
    Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Genes Cells 5:1029-37. 2000
    ..In this study, we applied DNA chip technology for isolating paternally expressed imprinted genes (Pegs). We compared the resulting expression profiles of parthenogenetic and fertilized control embryos to identify novel imprinted genes...
  9. pmc Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals
    Brad A Freking
    U S Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, Nebraska 68933 0166, USA
    Genome Res 12:1496-506. 2002
    ..Initial functional analysis indicates sequence encompassing the mutation is part of a novel transcript expressed in sheep fetal muscle we have named CLPG1...
  10. ncbi High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type
    Vera A E Van Limpt
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cancer 105:61-9. 2003
    ..By Serial Analysis of Gene Expression (SAGE), we previously identified the Drosophila Delta homologue Dlk1 as one of the genes most highly expressed in the neuroblastoma cell line SK-N-FI...
  11. ncbi Epigenetic detection of human chromosome 14 uniparental disomy
    S K Murphy
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Hum Mutat 22:92-7. 2003
    The recent demonstration of genomic imprinting of DLK1 and MEG3 on human chromosome 14q32 indicates that these genes might contribute to the discordant phenotypes associated with uniparental disomy (UPD) of chromosome 14...
  12. ncbi Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1
    Basem M Abdallah
    Department of Endocrinology, Univerity Hospital of Odense, Odense, Denmark
    J Bone Miner Res 19:841-52. 2004
    Dlk-1/Pref-1 was identified as a novel regulator of human skeletal stem cell differentiation. Dlk1/Pref-1 is expressed in bone and cultured osteoblasts, and its constitutive overexpression led to inhibition of osteoblast and adipocyte ..
  13. pmc Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour
    D Astuti
    Department of Paediatrics and Child Health, Section of Medical and Molecular Genetics, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 92:1574-80. 2005
    ..imprinted gene cluster at 14q32 has been defined and includes two closely linked but reciprocally imprinted genes, DLK1 and GTL2, that have similarities to IGF2 and H19, respectively...
  14. ncbi Dlk1 in normal and abnormal hematopoiesis
    S Sakajiri
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA, Los Angeles, CA 90048, USA
    Leukemia 19:1404-10. 2005
    b>Dlk1 (Pref-1) is a transmembrane and secreted protein, which is a member of the epidermal growth factor-like family, homologous to Notch/Delta/Serrate...
  15. ncbi DLK1: increased expression in gliomas and associated with oncogenic activities
    D Yin
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncogene 25:1852-61. 2006
    b>DLK1 (delta-like) is a transmembrane and secreted protein in the epidermal growth factor-like homeotic family. Although expressed widely during embryonic development, only a few tissues retain the expression in adults...
  16. ncbi Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma
    Takahiro Kawakami
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Hum Mol Genet 15:821-30. 2006
    ..We report that imprinted DLK1 at 14q32, a regulator of adipocyte differentiation, is a candidate TSG in RCCs...
  17. ncbi dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors
    Basem M Abdallah
    KMEB Laboratory, Medical Biotechnology Center, Odense University Hospital, Southern Denmark University, DK 5000 Odense, Denmark
    J Biol Chem 282:7339-51. 2007
    b>dlk1/FA1 (delta-like 1/fetal antigen-1) is a member of the epidermal growth factor-like homeotic protein family whose expression is known to modulate the differentiation signals of mesenchymal and hematopoietic stem cells in bone marrow...
  18. ncbi Methylation analysis of the intergenic differentially methylated region of DLK1-GTL2 in human
    Elke Geuns
    Research Centre Reproduction and Genetics, University Hospital and Medical School of the Vrije Universiteit Brussel, Laarbeeklaan, Brussels, Belgium
    Eur J Hum Genet 15:352-61. 2007
    ..We studied the methylation patterns of the intergenic (IG)-DMR of DLK1 and GTL2...
  19. doi Delta-like 1 (Dlk-1), a novel marker of prostate basal and candidate epithelial stem cells, is downregulated by notch signalling in intermediate/transit amplifying cells of the human prostate
    Jens A Ceder
    Lund University, Department of Clinical Sciences, Division of Urological Research, University Hospital MAS, Malmo, Sweden
    Eur Urol 54:1344-53. 2008
    ..There is a lack of understanding of the processes that regulate differentiation in the prostate...
  20. pmc The evolution of the DLK1-DIO3 imprinted domain in mammals
    Carol A Edwards
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS Biol 6:e135. 2008
    ..The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and ..
  21. ncbi Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14
    Tsutomu Ogata
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan
    Epigenetics 3:181-7. 2008
    Human chromosome 14q32.2 carries a cluster of imprinted genes including paternally expressed genes (PEGs) such as DLK1 and RTL1, and maternally expressed genes (MEGs) such as GTL2 (alias, MEG3), RTL1as (RTL1 antisense) and MEG8...
  22. pmc Minireview: Pref-1: role in adipogenesis and mesenchymal cell fate
    Hei Sook Sul
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    Mol Endocrinol 23:1717-25. 2009
    Preadipocyte factor-1 [Pref-1; also called Dlk1 (Delta-like protein 1)] is made as an epidermal growth factor-repeat containing transmembrane protein that produces a biologically active soluble form by TNF-alpha-converting enzyme (TACE)-..
  23. doi An upstream insulator regulates DLK1 imprinting in AML
    Haytham Khoury
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, Canada
    Blood 115:2260-3. 2010
    b>DLK1 is an imprinted gene on chromosome 14...
  24. doi Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma
    Feng Yu
    Institute of Life Sciences, Jiangsu University, Zhenjiang, China
    Liver Int 30:703-14. 2010
    Delta-like 1 (DLK1), a fetal liver stem cell marker, is strongly expressed in human and rodent fetal liver, but not in adult liver. Notably, dysregulation of DLK1 was found in some human hepatocellular carcinomas (HCC)...
  25. doi Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency
    Hiroyuki Yanai
    LivTech Inc, Teikyo University Biotechnology Research Centre 1F, 907 Nogawa, Miyamae, Kawasaki, Kanagawa 216 0001, Japan
    J Biochem 148:85-92. 2010
    Delta-like 1 protein (Dlk-1), also known as preadipocyte factor 1 (Pref-1), is a transmembrane and secreted protein with epidermal growth factor (EGF)-like repeats...
  26. pmc Pref-1 interacts with fibronectin to inhibit adipocyte differentiation
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720, USA
    Mol Cell Biol 30:3480-92. 2010
    Pref-1/Dlk1 is made as an epidermal growth factor (EGF) repeat-containing transmembrane protein but is cleaved by tumor necrosis factor alpha converting enzyme (TACE) to generate a biologically active soluble form...
  27. doi [Study on the molecular mechanisms of dlk1 stimulated lung cancer cell proliferation]
    Yu Liu
    Department of Etiology and Carcinogenesis, Chinese Academy of Medical Sciences, Beijing 100021, China
    Zhongguo Fei Ai Za Zhi 13:923-7. 2010
    The imprinted gene dlk1 has been recognized as a cancer related gene since it aberrantly expressed in a series of cancer tissues, but its role in lung cancer is still unknown...
  28. pmc DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival
    John M Luk
    Cancer Science Institute and Department of Pharmacology, National University of Singapore, 117597, Singapore
    J Biol Chem 286:30706-13. 2011
    ..a TRE-c-Met-driven transgenic HCC mouse model, we identified a cluster of 23 miRNAs that is encoded within the Dlk1-Gtl2 imprinted region on chromosome 12qF1 overexpressed in all of the isolated liver tumors...
  29. pmc Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
    Sacri R Ferron
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Nature 475:381-5. 2011
    The gene for the atypical NOTCH ligand delta-like homologue 1 (Dlk1) encodes membrane-bound and secreted isoforms that function in several developmental processes in vitro and in vivo...
  30. doi DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma
    Xiao Xu
    National Human Genome Center of Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Mol Cancer Ther 11:629-38. 2012
    Delta-like 1 homolog (DLK1; Drosophila) is a hepatic stem/progenitor cell marker in fetal livers that plays a vital role in oncogenesis of hepatocellular carcinoma (HCC)...
  31. doi The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis
    Leonidas Benetatos
    Transfusion Unit, General Hospital of Preveza, Selefkias 2, 48100, Preveza, Greece
    Cell Mol Life Sci 70:795-814. 2013
    ..In humans, the DLK1-DIO3 genomic region, located on human chromosome 14 (14q32) contains the paternally expressed imprinted genes DLK1, ..
  32. pmc Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation
    A A Wylie
    Department of Radiation Oncology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Genome Res 10:1711-8. 2000
    ..Here we report the identification of two reciprocally imprinted genes, GTL2 and DLK1, which together define a novel imprinting cluster on human chromosome 14q32...
  33. ncbi Imprinting status of DLK1 gene in brain tumors and lymphomas
    Dong Yin
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Int J Oncol 24:1011-5. 2004
    b>DLK1 and GTL2 are reciprocally imprinted genes on human chromosome 14q32. DLK1 encodes a transmembrane protein that is a paternally expressed gene. The maternally expressed GTL2 allele encodes a non-translated RNA...
  34. ncbi Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation
    Liang Li
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Oncogene 24:4472-6. 2005
    The Delta-like (DLK1) gene is overexpressed in CD34+ cells from myelodysplastic syndrome (MDS) patients. DLK1 encodes an EGF-like homeotic transmembrane protein homologous to the notch/delta/serrate family...
  35. doi Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes
    Masayo Kagami
    Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    Nat Genet 40:237-42. 2008
    Human chromosome 14q32.2 carries a cluster of imprinted genes including paternally expressed genes (PEGs) such as DLK1 and RTL1 and maternally expressed genes (MEGs) such as MEG3 (also known as GTL2), RTL1as (RTL1 antisense) and MEG8 (..
  36. pmc The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
    Chris Wallace
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:68-71. 2010
    ..79). This marker is in the imprinted region of chromosome 14q32.2, which contains the functional candidate gene DLK1. Our meta-analysis also provided support at genome-wide significance for a T1D locus at chromosome 19p13.2...
  37. pmc At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1
    John P Hagan
    Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 4:e4352. 2009
    ..In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is implicated in several diseases including Prader-Willi/Angelman syndromes and cancer...
  38. pmc Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region
    Ekaterina Y Steshina
    Department of Biological Sciences, The University of Illinois at Chicago, 900 S, Ashland Avenue, MC 567, Chicago, IL 60607, USA
    BMC Genet 7:44. 2006
    The Dlk1 and Gtl2 genes define a region of mouse chromosome 12 that is subject to genomic imprinting, the parental allele-specific expression of a gene...
  39. pmc Structural conservation versus functional divergence of maternally expressed microRNAs in the Dlk1/Gtl2 imprinting region
    Martin Kircher
    Max Planck Institut für Informatik, Saarbrucken, Germany
    BMC Genomics 9:346. 2008
    ..One of the largest known microRNA clusters is located within the imprinted Dlk1/Gtl2 region on human chromosome 14 and mouse chromosome 12...
  40. pmc Defining contributions of paternally methylated imprinted genes at the Igf2-H19 and Dlk1-Gtl2 domains to mouse placentation by transcriptomic analysis
    Manabu Kawahara
    Department of Bioscience, Tokyo University of Agriculture, Setagaya Ku, Tokyo 156 8502, Japan
    J Biol Chem 284:17751-65. 2009
    ..functions specific to paternally methylated imprinted genes regulated by the Igf2-H19 imprinting control region and Dlk1-Dio3 imprinting control region...
  41. ncbi Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
    Shau Ping Lin
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nat Genet 35:97-102. 2003
    ..5). The 1-Mb cluster contains the paternally expressed protein-coding genes Dlk1 (refs. 6,7) and Dio3 (ref. 8,9) and several maternally expressed non-coding RNAs, including Gtl2 (refs...
  42. doi The ontogeny of delta-like protein 1 messenger ribonucleic acid expression during muscle development and regeneration: comparison of broiler and Leghorn chickens
    J Shin
    Department of Animal Sciences, and The Ohio State University Interdisciplinary PhD Program in Nutrition OSUN, The Ohio State University, Columbus 43210, USA
    Poult Sci 88:1427-37. 2009
    Delta-like protein 1 (DLK1) has been implicated in the muscle hypertrophy observed in DLK1 transgenic mice, callipyge sheep, and mouse paternal uniparental disomy 12 and human paternal uniparental disomy 14 syndromes...
  43. ncbi [The relation between fasting plasma glucose concentrations and insulin resistance]
    Ling Li
    Department of Endocrinology, The Second Hospital, China Medical University, Shenyang 110004, China
    Zhonghua Nei Ke Za Zhi 44:755-8. 2005
    ..To study whether insulin resistance exists in the Chinese individuals with impaired glucose regulation (IGR) defined by the modified cut-point value (5.6 mmol/L) in 2003 version of ADA criteria for impaired fasting glucose (IFG)...
  44. ncbi [Deep lamellar keratoplasty versus penetrating keratoplasty for keratoconus]
    B Vabres
    Service d Ophtalmologie, CHU Nantes, Hotel Dieu, Place Alexis Ricordeau, 44093 Nantes Cedex 01
    J Fr Ophtalmol 29:361-71. 2006
    To determine the advantages, safety, and accuracy of deep anterior lamellar keratoplasty (DLK) versus penetrating keratoplasty (PK) in terms of visual acuity, astigmatism, and endothelial preservation in corneal diseases with healthy ..
  45. ncbi Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs
    Kwan Suk Kim
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011, USA
    Mamm Genome 15:552-9. 2004
    ..The callipyge locus (CLPG) maps to the distal portion of ovine Chromosome 18 within the DLK1- GTL2 region and corresponds to human Chromosome 14q32, where uniparental disomy (UPD) of the region is associated ..
  46. ncbi Suppression subtractive hybridization as a basis to assess Mycoplasma agalactiae and Mycoplasma bovis genomic diversity and species-specific sequences
    Marc S Marenda
    UMR INRA ENVT 1225, Ecole Nationale Veterinaire de Toulouse, 23 Ch des Capelles, 31076 Toulouse, France
    Microbiology 151:475-89. 2005
    ..bovis type-strain PG45 or for M. agalactiae type-strain PG2 were isolated by suppression subtractive hybridization and used as probes on a panel of M. agalactiae and M...
  47. ncbi Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells
    S K Halder
    Department of Molecular Physiological Chemistry, Osaka University Medical School, Suita, Japan
    Endocrinology 139:3316-28. 1998
    ....
  48. ncbi Deep lamellar keratoplasty versus penetrating keratoplasty for corneal lesions
    A Panda
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Cornea 18:172-5. 1999
    To compare the effectiveness of deep lamellar keratoplasty (DLK) with that of penetrating keratoplasty (PKP) in cases of corneal lesions not involving the endothelium.
  49. pmc Comparative genomic and proteomic analyses of two Mycoplasma agalactiae strains: clues to the macro- and micro-events that are shaping mycoplasma diversity
    Laurent X Nouvel
    Universite de Toulouse, ENVT, UMR 1225 Interactions Hôtes Agents Pathogènes, 31076 Toulouse, France
    BMC Genomics 11:86. 2010
    ..we compared two strains that are representative of the genetic spectrum encountered in this species: the type strain PG2 which genome is already available and a field strain, 5632, which was fully sequenced and annotated in this study.
  50. ncbi Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
    S Takada
    Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
    Curr Biol 10:1135-8. 2000
    ..A reciprocally imprinted gene, Delta-like (Dlk), with homology to genes involved in the Notch signalling pathway was identified 80kb upstream of Gtl2...
  51. doi Structural and phylogenetic comparison of three pepsinogens from Pacific bluefin tuna: molecular evolution of fish pepsinogens
    Masao Tanji
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 152:9-19. 2009
    The amino acid sequences of three pepsinogens (PG1, PG2 and PG3) of Pacific bluefin tuna (Thunnus orientalis) were deduced by cloning and nucleotide sequencing of the corresponding cDNAs...
  52. ncbi Patterns of rejection after deep lamellar keratoplasty
    Stephanie L Watson
    Cornea and External Diseases, Moorfields Eye Hospital National Health Service Foundation Trust, London, United Kingdom
    Ophthalmology 113:556-60. 2006
    To describe 7 patients with keratoconus who underwent graft rejection after deep lamellar keratoplasty (DLK).
  53. ncbi Differential expression of delta-like gene and protein in neuroblastoma, ganglioneuroblastoma and ganglioneuroma
    Chih Cheng Hsiao
    Department of Pediatrics, Division of Hematology Oncology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Mod Pathol 18:656-62. 2005
    ..An epidermal growth factor-like homeotic protein, delta-like (dlk), has been involved in differentiation of neuroblastoma cell lines, but is unknown in in vivo expression of ..
  54. ncbi Localization of the mixed-lineage kinase DLK/MUK/ZPK to the Golgi apparatus in NIH 3T3 cells
    M Douziech
    Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Histochem Cytochem 47:1287-96. 1999
    b>DLK/MUK/ZPK is a serine/threonine kinase that belongs to the mixed-lineage (MLK) subfamily of protein kinases...
  55. pmc Reduction of tomato polygalacturonase beta subunit expression affects pectin solubilization and degradation during fruit ripening
    C F Watson
    Department of Plant Sciences, University of Arizona, Tucson 85721
    Plant Cell 6:1623-34. 1994
    ..Two PG isoenzymes can be extracted from ripe fruit: PG2, which is a single catalytic PG polypeptide, and PG1, which is composed of PG2 tightly associated with a second ..
  56. ncbi An adipocentric view of liver fibrosis and cirrhosis
    Jiin Haur Chuang
    Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, ROC
    Chang Gung Med J 27:855-68. 2004
    ..proliferator-activated receptors (PPARs), leptin, adiponectin, and preadipocyte factor-1/delta-like1 (Pref-1/dlk1) are hormones, growth factors, nuclear receptors, and cytokines that are actively involved in lipid metabolism...
  57. doi dlk1 specifically interacts with insulin-like growth factor binding protein 1 to modulate adipogenesis of 3T3-L1 cells
    Maria Luisa Nueda
    Department of Inorganic and Organic Chemistry and Biochemistry, Medical School, Regional Center for Biomedical Research, University of Castilla La Mancha, Avenida de Almansa 14, 02006 Albacete, Spain
    J Mol Biol 379:428-42. 2008
    b>dlk1 is an epidermal growth factor (EGF)-like homeotic protein containing an intracellular region, a single transmembrane domain, and an extracellular region possessing six EGF-like repeats and a protease-target sequence...
  58. ncbi Multiple forms of polygalacturonase from banana fruits
    N Pathak
    Department of Biochemistry, University of Lucknow, India
    Phytochemistry 48:249-55. 1998
    ..PG1 and PG3 were identified as endo-PG and PG2 as exo-PG on the basis of decrease in viscosity, increase in reducing sugar and the reaction product...
  59. doi Acanthamoeba keratitis associated with contact lens wear in Singapore
    Yong Ming Por
    Singapore National Eye Centre, Singapore, Republic of Singapore
    Am J Ophthalmol 148:7-12.e2. 2009
    ..To describe an outbreak of Acanthamoeba keratitis (AK) cases among contact lens wearers...
  60. doi Friedmanniella luteola sp. nov., Friedmanniella lucida sp. nov., Friedmanniella okinawensis sp. nov. and Friedmaniella sagamiharensis sp. nov., isolated from spiders
    Kimika Iwai
    Innovative Drug Research Laboratories, Kyowa Hakko Kirin Co, Ltd 3 6 6, Asahi machi, Machida shi, Tokyo 194 8533, Japan
    Int J Syst Evol Microbiol 60:113-20. 2010
    ..Two strains (FA1(T) and FA2(T)) formed a cluster together with Friedmanniella capsulata and Friedmanniella lacustris and the other ..
  61. doi Variation in the cellular localization of host-protective oncospheral antigens in Taenia saginata and Taenia solium
    A Jabbar
    Department of Veterinary Science, The University of Melbourne, Werribee, Vic, Australia
    Parasite Immunol 32:684-95. 2010
    ..In addition, there was less intense staining of TSA9 and TSOL45 in the quadri-nucleate penetration gland type 2 (PG2) cell. TSA18, TSOL16 and TSOL18 were predominantly found in the PG2 cell...
  62. ncbi Autologous limbal grafting combined with deep lamellar keratoplasty in unilateral eye with severe chemical or thermal burn at late stage
    Yu feng Yao
    Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China
    Ophthalmology 109:2011-7. 2002
    To evaluate the efficacy of autologous limbal transplantation (ALT) combined with deep lamellar keratoplasty (DLK) for ocular surface reconstruction and corneal clarity recovery in eyes with severe late-stage chemical or thermal burns.
  63. ncbi Purification and characterization of pepsinogens from the gastric mucosa of African coelacanth, Latimeria chalumnae, and properties of the major pepsins
    Masao Tanji
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 8654, Japan
    Comp Biochem Physiol B Biochem Mol Biol 146:412-20. 2007
    Two major pepsinogens, PG1 and PG2, and one minor pepsinogen, PG3, were purified from the gastric mucosa of African coelacanth, Latimeria chalumnae (Actinistia). PG1 and PG2 were much less acidic than PG3...
  64. doi Origin, evolution, and biological role of miRNA cluster in DLK-DIO3 genomic region in placental mammals
    Evgeny A Glazov
    Commonwealth Scientific and Industrial Research Organisation CSIRO Livestock Industries, Queensland Bioscience Precinct QBP, St Lucia, Brisbane, Queensland, Australia
    Mol Biol Evol 25:939-48. 2008
    ..describe a detailed analysis of the miRNA cluster (hereafter mir-379/mir-656 cluster) located within the imprinted DLK-DIO3 region on human chromosome 14...
  65. doi Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells
    Margareta H Lejonklou
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    Pancreas 38:259-66. 2009
    ....
  66. pmc Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing
    Baisong Mei
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Biochem J 364:137-44. 2002
    ..We conclude that only the large soluble form, and not the transmembrane or the small soluble form, of Pref-1 is biologically active and that alternative splicing therefore determines Pref-1 function in adipocyte differentiation...
  67. ncbi Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides
    D L Kirkpatrick
    Department of Chemistry, University of Regina, SK, Canada
    Biochem Pharmacol 55:987-94. 1998
    ..Disulfides IV-2 (1-methylpropyl 2-mercaptoimidazolyl disulfide) and DLK-36 (benzyl 2-mercaptoimidazolyl disulfide) were competitive inhibitors of the reduction of hTrx by TR with Ki ..
  68. ncbi Keratocyte activation and inflammation in diffuse lamellar keratitis after formation of an epithelial defect
    Jukka A O Moilanen
    Department of Ophthalmology, University of Helsinki, Helsinki, Finland
    J Cataract Refract Surg 30:341-9. 2004
    To examine the inflammatory reaction in acute or late-onset post-laser in situ keratomileusis (LASIK) diffuse lamellar keratitis (DLK) associated with an epithelial defect.
  69. ncbi Comparative cohort study of the outcomes of deep lamellar keratoplasty and penetrating keratoplasty for keratoconus
    C L Funnell
    Department of Ophthalmology, Leeds Teaching Hospitals Trust, Leeds, UK
    Eye (Lond) 20:527-32. 2006
    To compare the outcomes and complications of deep lamellar keratoplasty (DLK) and penetrating keratoplasty (PK) for keratoconus.
  70. doi Role of Hox PG2 genes in Nile tilapia pharyngeal arch specification: implications for gnathostome pharyngeal arch evolution
    Pierre Le Pabic
    Department of Biology, East Carolina University, Greenville, NC 27858, USA
    Evol Dev 12:45-60. 2010
    ..Genome duplication at the inception of the teleosts likely generated four Hox PG2 genes, only two of which, hoxa2b and b2a, have been preserved in zebrafish, where they serve as functionally ..
  71. pmc Expression of stem cell markers in the human fetal kidney
    Sally Metsuyanim
    Department of Pediatrics and Pediatric Stem Cell Research Institute, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 4:e6709. 2009
    ..up-regulated in microarrays of both HFK and blastema-enriched stem-like wilms' tumor xenografts (NCAM, ACVRIIB, DLK1/PREF, GPR39, FZD7, FZD2, NTRK2) are likely to be relevant markers...
  72. ncbi Diffuse lamellar keratitis: isolation of endotoxin and demonstration of the inflammatory potential in a rabbit laser in situ keratomileusis model
    N T Peters
    Gimbel Eye Centre, Calgary, Alberta, Canada
    J Cataract Refract Surg 27:917-23. 2001
    ..examine sources of endotoxin contamination in eye centers as a potential cause of diffuse lamellar keratitis (DLK) and to demonstrate the inflammatory potential of endotoxin in a rabbit model of laser in situ keratomileusis (..
  73. ncbi Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis
    Susanne Vetterkind
    Institute of Genetics, University of Bonn, Römerstr 164, D 53117 Bonn, Germany
    Exp Cell Res 305:392-408. 2005
    ..Cell death mediated by Par-4 and its interaction partner DAP like kinase (Dlk) is characterized by dramatic changes of the cytoskeleton...
  74. ncbi Calcineurin-independent inhibition of 3T3-L1 adipogenesis by Pasteurella multocida toxin: suppression of Notch1, stabilization of beta-catenin and pre-adipocyte factor 1
    Leila R Aminova
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Cell Microbiol 9:2485-96. 2007
    ..Differentiation of pre-adipocytes into adipocytes requires the suppression of pre-adipocyte factor 1 (Pref1) and Wnt signalling, along with the degradation of beta-catenin...
  75. pmc VNTR analysis reveals unexpected genetic diversity within Mycoplasma agalactiae, the main causative agent of contagious agalactia
    Laura McAuliffe
    Mycoplasma Group, Department of Statutory and Exotic Bacteria, Veterinary Laboratories Agency Weybridge, Surrey, KT15 3NB, UK
    BMC Microbiol 8:193. 2008
    ..Previous studies of M. agalactiae have shown it to be unusually homogeneous and there are currently no available epidemiological techniques which enable a high degree of strain differentiation...
  76. ncbi Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes
    Stephane Labialle
    Department of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada
    Hum Mol Genet 17:15-26. 2008
    ....
  77. doi More constraint on ParaHox than Hox gene families in early metazoan evolution
    Manon Quiquand
    Department of Zoology and Animal Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneve 4, Switzerland
    Dev Biol 328:173-87. 2009
    ..In contrast to bilaterians, cnidarians express, beside PG1, PG2 and Gsx orthologs, numerous Hox-related genes with unclear origin...
  78. ncbi Degradation of PCDD/Fs by mechanochemical treatment of fly ash from medical waste incineration
    J H Yan
    State Key Laboratory of Clean Energy Utilization, Institute for Thermal Power Engineering, Zhejiang University, Hangzhou 310027, China
    J Hazard Mater 147:652-7. 2007
    ..compared, originating either from rotary kiln fluidized bed multi-stage incinerator using activated carbon spray (FA1, FA2), or a simple stoker incinerator without activated carbon spray (FA3)...
  79. ncbi Diffuse lamellar keratitis and corneal edema associated with viral keratoconjunctivitis 2 years after laser in situ keratomileusis
    Oscar Gris
    Instituto de Microcirugia Ocular, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Cataract Refract Surg 30:1366-70. 2004
    ..previously for myopia and astigmatism, presented with bilateral loss of vision due to diffuse lamellar keratitis (DLK) with corneal edema in the context of a pseudomembranous viral keratoconjunctivitis...
  80. ncbi Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse
    Yuzuru Kato
    Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    Hum Mol Genet 16:2272-80. 2007
    ..We have performed a detailed methylation analysis of the paternally methylated DMRs (H19, Dlk1/Gtl2 and Rasgrf1), interspersed repeats [SineB1, intracisternal A particle (IAP) and Line1] and satellite repeats (..
  81. ncbi Congenic mapping of type 1 diabetes--protective gene(s) in an interval of 4 Mb on rat chromosome 6q32
    Nora Kloting
    Department of Laboratory Animal Science, Medical Faculty, University of Greifswald, Karlsburg, Germany
    Biochem Biophys Res Commun 323:388-94. 2004
    ..To identify underlying gene(s), the introgressed segment was shortened and the expression of seven genes (Yy1, Dlk1/Pref-1, Wd40 repeat, Cdc42, Rtl1, Traf3, and Tnfaip2) was studied in blood and spleen of non-diabetic BB/OK, BB...
  82. ncbi Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications
    B N Friedrichsen
    Hagedorn Research Institute, Gentofte, Denmark and Department of Islet Discovery, Novo Nordisk A S, Bagsvaerd, Denmark
    J Endocrinol 176:257-66. 2003
    Preadipocyte factor-1 (Pref-1)/delta-like protein/fetal antigen-1 (FA1) is a member of the epidermal growth factor-like family...
  83. doi Cloning of avian Delta-like 1 homolog gene: the biallelic expression of Delta-like 1 homolog in avian species
    S Shin
    Department of Animal Sciences, The Ohio State University, Columbus 43210, USA
    Poult Sci 89:948-55. 2010
    Delta-like 1 homolog (Dlk1) is a paternally expressed imprinted gene in mammals, regulating development and differentiation of adipose and muscle...
  84. ncbi Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases
    L B Holzman
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109 0676
    J Biol Chem 269:30808-17. 1994
    ..Several receptor tyrosine kinase and serine/threonine kinase cDNA clones were identified. One of these, designated DLK, represented a novel gene product whose 3...
  85. ncbi Late onset diffuse lamellar keratitis as a result of the toxic effect of Ecballium elaterium herb
    Ibrahim Koçak
    Department of Ophthalmology, Nisa Hospital, Istanbul, Turkey
    J Refract Surg 22:826-7. 2006
    To report a case of late onset diffuse lamellar keratitis (DLK) 11 months after LASIK due to Ecballium elaterium exposure.
  86. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Zac1 alters the expression of several of these imprinted genes, including Igf2, H19, Cdkn1c, and Dlk1, and it directly regulates the Igf2/H19 locus through binding to a shared enhancer...
  87. ncbi Idiopathic recurrence of diffuse lamellar keratitis after LASIK
    George D Kymionis
    Department of Ophthalmology, University of Crete, Greece
    J Refract Surg 23:720-1. 2007
    To report a case of late recurrence of bilateral diffuse lamellar keratitis (DLK) after LASIK.
  88. ncbi Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A
    Silke Plaumann
    Molecular Pharmacology, University of Gottingen, Robert Koch Str 40, 37099 Gottingen, Germany
    Mol Pharmacol 73:652-9. 2008
    ..In the present study, the effect of cyclosporin A and the dual leucine-zipper-bearing kinase (DLK) on beta-cell survival was investigated...
  89. pmc Glucocorticoid signaling defines a novel commitment state during adipogenesis in vitro
    Carlos Pantoja
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94107 2280, USA
    Mol Biol Cell 19:4032-41. 2008
    ..We conclude that glucocorticoids drive preadipocytes to a novel intermediate cellular state, the dex-primed preadipocyte, during adipogenesis in cell culture, and that Pref-1 repression may be a cell fate determinant in preadipocytes...
  90. pmc Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy
    Josep A Villena
    Department of Nutritional Science and Toxicology, University of California, Berkeley, CA, USA
    Diabetes 57:3258-66. 2008
    ..In this study, we have investigated the effects of Pref-1 overexpression on whole-body glucose homeostasis and its contribution to the development of insulin resistance...
  91. pmc Array comparative genomic hybridization-based characterization of genetic alterations in pulmonary neuroendocrine tumors
    Johannes Voortman
    Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:13040-5. 2010
    ..CN alterations were observed in 203 genes, including the RB1 gene and 59 microRNAs of which 51 locate in the DLK1-DIO3 domain. These findings suggest the existence of partially shared CN alterations in these tumor types...
  92. doi MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas
    Henriett Butz
    2nd Department of Medicine, Faculty of Medicine, Semmelweis University, 46 Szentkiralyi str, Budapest 1088, Hungary
    Pituitary 14:112-24. 2011
    ..Five overexpressed miRs and mRNA expression of Smads (Smad1-9), MEG and DLK1 genes were evaluated with individual Taqman assays in 10 NFPA and 10 normal pituitary tissues...
  93. doi Possible roles of DLK1 in the Notch pathway during development and disease
    Farah A Falix
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Biochim Biophys Acta 1822:988-95. 2012
    ..The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, ..
  94. doi Dissecting the genotype in syndromic intellectual disability using whole exome sequencing in addition to genome-wide copy number analysis
    Carl Friedrich Classen
    Department of Pediatrics, University Hospital, Ernst Heydemann Str 8, 18057 Rostock, Germany
    Hum Genet 132:825-41. 2013
    ..microdeletion, tall stature and renal malformation were unexplained by paternal UPD(14), and there was no altered DLK1 expression or unexpected methylation status...
  95. pmc Functional annotation and structural characterization of a novel lactonase hydrolyzing D-xylono-1,4-lactone-5-phosphate and L-arabino-1,4-lactone-5-phosphate
    Magdalena Korczynska
    Department of Pharmaceutical Chemistry, University of California, San Francisco, 1700 Fourth Street, San Francisco, California 94158 2330, United States
    Biochemistry 53:4727-38. 2014
    A novel lactonase from Mycoplasma synoviae 53 (MS53_0025) and Mycoplasma agalactiae PG2 (MAG_6390) was characterized by protein structure determination, molecular docking, gene context analysis, and library screening...
  96. doi Delta-like 1 homolog (DLK1) inhibits proliferation and myotube formation of avian QM7 myoblasts
    Sangsu Shin
    Department of Animal Sciences, The Ohio State University, Columbus, OH 43210, USA Life and Industry Convergence Research Institute, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongnam 627 706, Republic of Korea
    Comp Biochem Physiol B Biochem Mol Biol 179:37-43. 2015
    Delta-like 1 homolog (DLK1) has been implicated as an important regulator in mammalian muscle development...
  97. doi [Complications of corneal lamellar refractive surgery]
    T Kohnen
    Klinik fur Augenheilkunde, Goethe Universitat Frankfurt am Main, Theodor Stern Kai 7, 60590, Frankfurt am Main, Deutschland
    Ophthalmologe 112:982-9. 2015
    ..g. diffuse lamellar keratitis, DLK), epithelial or flap folds, epithelial ingrowths or iatrogenic ectasia...
  98. doi Deletion of the miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour
    Virginie Marty
    Laboratoire de Biologie Moleculaire Eucaryote, Universite de Toulouse, UPS and CNRS, LBME, F 31000 Toulouse, France
    Hum Mol Genet 25:728-39. 2016
    The brain-specific miR-379/miR-410 gene cluster at the imprinted Dlk1-Dio3 domain is implicated in several aspects of brain development and function, particularly in fine-tuning the dendritic outgrowth and spine remodelling of hippocampal ..
  99. pmc Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth
    Samuel H Chung
    School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138 Department of Physiology and Biophysics, Boston University School of Medicine, Boston, MA 02118 Boston University Photonics Center, Boston, MA 02215
    Proc Natl Acad Sci U S A 113:E2852-60. 2016
    ..Here, we identify a novel form of neuronal regeneration, which is remarkably independent of DLK-1/DLK, KGB-1/JNK, and other MAPK signaling factors known to mediate regeneration in Caenorhabditis elegans, ..
  100. pmc Erasure of DNA methylation, genomic imprints, and epimutations in a primordial germ-cell model derived from mouse pluripotent stem cells
    Norikatsu Miyoshi
    Massachusetts General Hospital Center for Cancer Research, Charlestown, MA 02129
    Proc Natl Acad Sci U S A 113:9545-50. 2016
    ..PSCs harboring abnormal hypermethylation at ICRs of the Dlk1-Gtl2-Dio3 imprinting cluster diminished these 5meCs upon differentiation to PGCLCs, resulting in transcriptional ..
  101. pmc Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice
    Takeshi Saito
    Department of Systems Biomedicine, National Research Institute for Child Health and Development, Tokyo 157 8535, Japan
    J Reprod Dev . 2016
    Expression regulation of the Dlk1-Dio3 imprinted domain by the intergenic differentially methylated region (IG-DMR) is essential for normal embryonic development in mammals...

Research Grants36

  1. Protease Inhibitor Related Adipogenesis in HIV Infection
    Krishna Agrawal; Fiscal Year: 2003
    ..These studies will delineate the molecular mechanisms that may be responsible for the adipogenic side effects induced by the PIs in the presence of HIV infection. ..
  2. Molecular Pathology in Polycystic Kidney Disease
    Jing Zhou; Fiscal Year: 2010
    ..These data led us to propose a model in which PC1 and PG2 form a mechanosensitive receptor channel complex and mediate fluid flow sensation in primary cilia of renal ..
  3. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
    ..parental repression of juxtapositioned genes by an intervening imprint center will be modeled by the IGF2/H19 and DLK1/MEG3 imprinted domains...
  4. The Role of Foxa2 in Metabolism
    Markus Stoffel; Fiscal Year: 2006
    ..Investigate the link between FOXA2 adipocyte expression and obesity/insulin resistance in humans and 4) contribute to our basic understanding of transcriptional pathways that are regulated by insulin. ..
  5. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2003
    ....
  6. Nutrition, Deregulation of Imprinted Genes
    Cathrine Hoyo; Fiscal Year: 2013
    ..b>DLK1 exhibits many of the same structural and regulatory characteristics of the coordinately regulated IGF2 imprinted ..
  7. Obesity and deregulation of imprinted genes in early life
    Susan Kay Murphy; Fiscal Year: 2013
    ..b>DLK1 is elevated in the circulation of obese hu- mans, and both DLK1 and NNAT are involved in adipogenesis...
  8. Pref-1 function and regulation in adipogenesis
    Hei Sook Sul; Fiscal Year: 2013
    ..Elucidating the mechanisms of Pref-1 function and regulation will allow us to begin to develop strategies to control obesity. ..
  9. Eva E Redei; Fiscal Year: 2014
    ..These genes include, the Delta-like (Dlk), type 3 deiodinase (Dio3), G-protein -subunit, Gs (Gnas) and its variants, necdin (Ndn), ubiquitin protein ligase ..
  10. Meifan Chen; Fiscal Year: 2015
    ..regeneration because it is one of two mammalian homologues of the invertebrate dual leucine zipper-bearing kinase DLK-1/Wallenda required for the regenerative response in Caenorhabditis elegans and Drosophila melanogaster...
  11. Elucidating adiposity in a mouse model of prenatal undernutrition
    ELVIRA MARIE ISGANAITIS; Fiscal Year: 2011
    ..Prenatally undernourished F1 mice have significant reductions in adipose tissue expression of Pref1, an imprinted gene that is a critical negative regulator of adipogenesis...
  12. ELVIRA MARIE ISGANAITIS; Fiscal Year: 2015
    ..Prenatally undernourished F1 mice have significant reductions in adipose tissue expression of Pref1, an imprinted gene that is a critical negative regulator of adipogenesis...
  13. Yishi Jin; Fiscal Year: 2016
    ..goal of this renewal application is to define the mechanisms of RNA based regulation in the conserved neuronal DLK-1 kinase pathway. Taking genetic approaches in C...
  14. Donald J Zack; Fiscal Year: 2016
    ..Through this work we have found that the dual leucine zipper kinase (DLK, MAP3K12)) is an attractive therapeutic target, and have shown that its inhibition both in vitro and in vivo ..
  15. David M Miller; Fiscal Year: 2014
    ..Recent work has demonstrated that the conserved DLK-1 signaling pathway is a critical regulator of regeneration...
  16. Aaron DiAntonio; Fiscal Year: 2016
    ..identified that regulate synaptic development and that interact with highwire and its target the MAPKKK Wallenda/DLK. Powerful genetic techniques will be used to analyze these mutants to define molecular pathways controlled by this ..
  17. Robert Rohrbaugh; Fiscal Year: 2016
    ..IMPORT) into the very earliest (PG1) stages of clinical residency training (in addition to continuing prior PG2 experiences), 2) to significantly broaden these early experiences through a novel integrated (PG3) clinical/..
  18. Catherine A Collins; Fiscal Year: 2016
    ..The focus of this study is the role and mechanism of a conserved axonal kinase, named Wallenda (Wnd) in Drosophila, DLK in vertebrates...
  19. Aaron DiAntonio; Fiscal Year: 2016
    ..We now demonstrate that the DLK pathway functions in the intrinsic neuronal pathway that promotes axonal degeneration following injury...
  20. Regulation of the DLK-1 pathway in axon regeneration
    Dong Yan; Fiscal Year: 2012
    ..My previous studies showed that regulation of cebp-1 mRNA stabilization and local protein translation by the DLK-1 pathway is required for successfully axon regeneration...
  21. PREF-1 FUNCTION IN ISLET GROWTH & DIFFERENTIATION
    Hei Sook Sul; Fiscal Year: 2000
    DESCRIPTION: (Adapted from the applicant's abstract) Preadipocyte factor 1 (pref- 1) is a transmembrane protein that contains epidermal growth factor-like repeats. Pref- 1 can be cleaved to generate a soluble factor...
  22. NOVEL SAPK ACTIVATING KINASE IN RENAL EPITHELIAL STRESS
    Lawrence Holzman; Fiscal Year: 2006
    ..We have identified, cloned from embryonic kidney, and initially characterized the protein kinase called DLK. DLK is a MAP kinase kinase kinase of the mixed lineage kinase family (MLK) that may be activated by cellular ..
  23. ORGANIZATION OF APICAL CELL JUNCTIONS IN EYE
    Kwang Wook Choi; Fiscal Year: 2005
    ..A novel Dlt homolog, Dlt-like (Dlk), also directly binds Par6...
  24. Regulation of Cellular Senescence by MEG3 RNA
    Yunli Zhou; Fiscal Year: 2007
    ..Therefore, another specific aim is to determine how MEGS activates p53. Whether MEG3 RNA activates p53 through repression of Mdm2 expression will be the focus of investigation. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Novel adipocyte-specific enzymes in triacylglycerol metabolism
    Hei Sook Sul; Fiscal Year: 2009
    ....
  26. ADSF/resistin function in adipocyte differentiation
    Hei Sook Sul; Fiscal Year: 2008
    ..It is important to elucidate the mechanisms of ADSF function in order to develop strategies for controlling adipogenesis as well as treating type 2 diabetes by modifying ADSF action. ..
  27. Clinical Phenotype of Imprinted Genes of Chromosome 14
    Vernon Sutton; Fiscal Year: 2005
    ..This phenotype delineation will lay the foundation for understanding the effects and pathogenesis of imprinted genes on chromosome 14. ..
  28. HORMONAL AND NUTRITIONAL CONTROL OF ENZYME BIOSYNTHESIS
    Hei Sook Sul; Fiscal Year: 2004
    ....
  29. ENZYMES IN PHOSPHATIDIC ACID BIOSYNTHESIS
    Hei Sook Sul; Fiscal Year: 2002
    ..She will also express this AGPAT in acyl-CoA. She will also determine the contribution of this AGPAT in the enrichment of long chain polyenoic acids at the sn-2 position of glycerophospholipids. ..
  30. CORNEAL LIPID METABOLISM AND RESPONSE TO INFLAMMATION
    Haydee E P Bazan; Fiscal Year: 2010
    ..If our hypothesis and its corollaries are correct, then PAF antagonists can become effective therapeutic tools for maintaining the transparency and integrity of the cornea. ..
  31. Role of hypoxia in the maintenance and homing of hematopoietic stem cells
    Zhong Yun; Fiscal Year: 2008
    ..In addition, discoveries regarding the in vivo microenvironment for HSCs could lead to improved engraftment following hematopoietic stem cell transplantation. [unreadable] [unreadable]..
  32. CELL SIGNAL TRANSDUCTION IN CORNEAL WOUND HEALING
    Haydee Bazan; Fiscal Year: 2006
    ..This knowledge will allow us to characterize drugs that target selective steps of the signaling pathways. [unreadable] [unreadable]..
  33. Regulation of APP Processing by Par-4
    Qing Guo; Fiscal Year: 2007
    ..Inhibition of Par-4 activity by enhancing AATF expression and/or manipulating Par-4/APP interaction may provide novel therapeutic implications for Alzheimer's disease. ..
  34. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  35. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  36. EXTRACEL MATRIX INTEGRIN SIGNALING IN PROSTATE CANCER
    Leland Chung; Fiscal Year: 2003
    ....