DLGAP1

Summary

Gene Symbol: DLGAP1
Description: DLG associated protein 1
Alias: DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, disks large-associated protein 1, PSD-95/SAP90 binding protein 1, SAP90/PSD-95-associated protein 1, discs large homolog associated protein 1, guanylate kinase-associated protein
Species: human

Top Publications

  1. ncbi Synapse formation by hippocampal neurons from agrin-deficient mice
    A S Serpinskaya
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, 61801, USA
    Dev Biol 205:65-78. 1999
  2. ncbi A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate
    M J Muñoz-Alonso
    CNRS UPR 1524, 9, rue Jules Hetzel, 92190 Meudon, INSERM U505, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 275:32406-12. 2000
  3. pmc Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
  4. pmc GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
  5. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
  6. ncbi Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 20:4524-34. 2000
  7. pmc Intramolecular interactions regulate SAP97 binding to GKAP
    H Wu
    University of Alabama at Birmingham, Department of Neurobiology, 1719 Sixth Avenue South CIRC 589, Birmingham, AL 35294 0021, USA
    EMBO J 19:5740-51. 2000
  8. doi Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system
    M Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Neuroscience 171:421-33. 2010
  9. ncbi Concentration-response relationships as a basis for choice of the optimal endpoints of the antimicrobial effect: daptomycin and vancomycin pharmacodynamics with staphylococci in an in vitro dynamic model
    Maria V Smirnova
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow 119021, Russia
    Int J Antimicrob Agents 29:165-9. 2007
  10. ncbi Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal
    D W Morrish
    Department of Medicine, University of Alberta, 362 Heritage Medical Research Center, Edmonton, Alberta, T6G 2S2, Canada
    Curr Protein Pept Sci 2:245-59. 2001

Research Grants

  1. Glutamate Receptor Trafficking in Visual Development
    Martha Constantine Paton; Fiscal Year: 2005
  2. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
  3. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2013
  4. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2011
  5. CHOEL WOONG KIM; Fiscal Year: 2016
  6. Modulation and Targeting of Kainate Receptors
    John Marshall; Fiscal Year: 2004
  7. CLUSTERING AND TARGETING ION CHANNELS TO THE SYNAPSE
    Vivian Budnik; Fiscal Year: 2002
  8. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
  9. E3KARP and cGMP regulation of NHE3
    Mark Donowitz; Fiscal Year: 2003
  10. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Synapse formation by hippocampal neurons from agrin-deficient mice
    A S Serpinskaya
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, 61801, USA
    Dev Biol 205:65-78. 1999
    ..AMPA- and NMDA-type glutamate receptors, GABAA receptors, and the putative synapse-organizing proteins PSD-95, GKAP, and gephyrin formed numerous clusters at synaptic sites...
  2. ncbi A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate
    M J Muñoz-Alonso
    CNRS UPR 1524, 9, rue Jules Hetzel, 92190 Meudon, INSERM U505, 15 rue de l Ecole de Medecine, 75006 Paris, France
    J Biol Chem 275:32406-12. 2000
    ..We called this protein the glucokinase-associated phosphatase (GKAP)...
  3. pmc Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation
    Roberto Amato
    Gruppo Interdipartimentale di Bioinformatica e Biologia Computazionale, Università di Napoli Federico II Università di Salerno, Naples, Italy
    BMC Evol Biol 10:351. 2010
    ..Nevertheless, also several diseases show latitudinal clinals such as hypertension, cancer, dismetabolic conditions, schizophrenia, Parkinson's disease and many more...
  4. pmc GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Cell Biol 136:669-78. 1997
    ..We now report the isolation of a novel synaptic protein, termed GKAP for guanylate kinase-associated protein, that binds directly to the GK domain of the four known members of the ..
  5. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
    ....
  6. ncbi Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 20:4524-34. 2000
    ..demonstrate a direct interaction between the PSD-95-associated protein guanylate kinase domain-associated protein (GKAP) and dynein light chain (DLC), a light chain subunit shared by myosin-V (an actin-based motor) and cytoplasmic ..
  7. pmc Intramolecular interactions regulate SAP97 binding to GKAP
    H Wu
    University of Alabama at Birmingham, Department of Neurobiology, 1719 Sixth Avenue South CIRC 589, Birmingham, AL 35294 0021, USA
    EMBO J 19:5740-51. 2000
    ..the molecular mechanisms that regulate the interaction of the MAGUK SAP97 with its GUK domain binding partner GKAP (GUK-associated protein). The GKAP-GUK interaction is regulated by a series of intramolecular interactions...
  8. doi Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system
    M Raab
    Department of Anatomy I, University of Erlangen Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, Germany
    Neuroscience 171:421-33. 2010
    ..protein 90/postsynaptic density protein-95-associated protein (SAPAP)/guanylate-kinase-associated protein (GKAP) interaction partners and also isolated from synaptic junctional protein preparations of rat brain...
  9. ncbi Concentration-response relationships as a basis for choice of the optimal endpoints of the antimicrobial effect: daptomycin and vancomycin pharmacodynamics with staphylococci in an in vitro dynamic model
    Maria V Smirnova
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow 119021, Russia
    Int J Antimicrob Agents 29:165-9. 2007
    ..The better abilities of ABBC and N(min) and the inability of T(90%) and T(99%) to provide reasonable AUC/MIC relationships with DAP and VAN support earlier findings reported with fluoroquinolones...
  10. ncbi Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal
    D W Morrish
    Department of Medicine, University of Alberta, 362 Heritage Medical Research Center, Edmonton, Alberta, T6G 2S2, Canada
    Curr Protein Pept Sci 2:245-59. 2001
    ..Thus, the placenta is both a rich source of new growth-regulatory substances, and a model system for originating new paradigms of developmental biology...
  11. ncbi A series of vanadogermanates from 1D chain to 3D framework built by Ge-V-O clusters and transition-metal-complex bridges
    Jian Zhou
    State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P R China
    Chemistry 16:13253-61. 2010
    ..Magnetic measurements illustrate that both 1 and 2 have antiferromagnetic exchange interactions between metal centers, whereas 3 exhibits ferrimagnetic behavior, which is rare in polyoxovanadate complexes...
  12. ncbi Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules
    D W Allison
    Department of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Neurosci 20:4545-54. 2000
    ..The same was largely true for GKAP, a PSD-95-interacting protein...
  13. ncbi A growing family of dual specificity phosphatases with low molecular masses
    N Aoki
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    J Biochem 130:133-40. 2001
    ..LMW-DSP4 exhibited the highest similarity to human YVH1 and rat GKAP, but its C-terminal region was much shorter than that of the human and rat clones...
  14. ncbi Synaptic localization of SAPAP1, a synaptic membrane-associated protein
    Ikuko Yao
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Genes Cells 8:121-9. 2003
    b>SAPAP1 was originally identified as a protein interacting with the guanylate kinase domain of PSD-95...
  15. ncbi Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole
    Anu K Kinnunen
    Novartis Pharma AG, Nervous System Research, Basel, Switzerland
    J Neurochem 86:736-48. 2003
    ....
  16. ncbi PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
    ..Furthermore, two additional components of the well characterized glutamatergic postsynaptic complex, GKAP/SAPAP (guanylate kinase domain-associated protein/synapse-associated protein-associated protein) and Shank/ProSAP ..
  17. ncbi Unbalanced whole arm translocation resulting in loss of 18p in dystonia
    Jamal Nasir
    Academic Neurology Unit, Section of Genetics and Informatics, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom
    Mov Disord 21:859-63. 2006
    ....
  18. pmc Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis
    Chan Hyun Na
    Departments of Structural Biology and Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Proteome Res 11:4722-32. 2012
    ..g., Bassoon, NSF, SNAP25, synapsin, synaptotagmin, and syntaxin) and postsynaptic density (e.g., PSD-95, GKAP, CaMKII, as well as receptors for NMDA, AMPA, GABA, serotonin, and acetylcholine)...
  19. doi Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia
    Jun Ming Li
    Department of Psychiatry, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan
    Psychiatry Res 205:13-7. 2013
    ..sequenced all the exons of the discs, large (Drosophila) homolog-associated protein 1 (DLGAP1) gene that encodes SAPAP1 in a sample of 121 schizophrenic patients and 120 controls from Taiwan...
  20. pmc MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density
    Nils Rademacher
    Neuroscience Research Center and Cluster of Excellence NeuroCure, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Sci Rep 6:35283. 2016
    ..by its C-terminal SH3-GK domain module, MPP2 binds to the abundant postsynaptic scaffold proteins PSD-95 and GKAP and localises to postsynaptic sites in hippocampal neurons...
  21. ncbi Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    S Naisbitt
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 23:569-82. 1999
    ..density (PSD) proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP. A ternary complex of Shank/GKAP/PSD-95 assembles in heterologous cells and can be coimmunoprecipitated from rat ..
  22. ncbi Synamon, a novel neuronal protein interacting with synapse-associated protein 90/postsynaptic density-95-associated protein
    I Yao
    Takai Biotimer Project, Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 274:27463-6. 1999
    Guanylate kinase-associated protein (GKAP)/SAP90/PSD-95-associated protein (SAPAP)/DLG-associated protein (DAP) is a protein of the postsynaptic density (PSD), and binds to the guanylate kinase domain of PSD-95/synapse-associated protein (..
  23. ncbi The Shank family of scaffold proteins
    M Sheng
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Cell Sci 113:1851-6. 2000
    ..for most of these domains have been identified: for instance, the PDZ domain of Shank proteins interacts with GKAP (a postsynaptic-density protein) as well as several G-protein-coupled receptors...
  24. ncbi Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique
    I Rodriguez-Crespo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense de Madrid, Spain
    FEBS Lett 503:135-41. 2001
    ..consensus sequences were identified: GIQVD present in nNOS, in DNA cytosine methyl transferase and also in GKAP, where it is present twice in the protein sequence...
  25. ncbi Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein
    Ikuko Yao
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurosci 22:5354-64. 2002
    ....
  26. ncbi Direct interaction with a kinesin-related motor mediates transport of mammalian discs large tumor suppressor homologue in epithelial cells
    Noriyuki Asaba
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 278:8395-400. 2003
    ..This stalk segment is not found in GKAP, a synaptic protein that interacts with the guanylate kinase-like domain, and unlike GKAP, the binding of GAKIN is ..
  27. ncbi Mutation and association analysis of the DAP-1 gene with schizophrenia
    Shinsuke Aoyama
    Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan
    Psychiatry Clin Neurosci 57:545-7. 2003
    ..The results do not provide evidence that the DAP-1 gene is involved in vulnerability to schizophrenia...
  28. ncbi Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18
    Ben S Pickard
    Department of Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Psychiatr Genet 15:37-44. 2005
    ..in these families; TTMA, a novel membrane spanning protein; TCF4, a basic helix-loop-helix transcription factor; DLGAP1, an interactor of the PSD-95 synaptic protein; and ARKL1 and ARKL2, novel members of the ubiquitin ligase gene ..
  29. ncbi Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model
    Alexander A Firsov
    Department of Pharmacokinetics and Pharmacodynamics, Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 Bolshaya Pirogovskaya Street, Moscow, 119021 Russia
    J Antimicrob Chemother 58:1185-92. 2006
    ....
  30. pmc Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities
    Janin Schütt
    Institute for Human Genetics, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    J Biol Chem 284:25479-87. 2009
    ..levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP...
  31. doi 3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS
    Shin J Oh
    Department of Neurology, University of Alabama at Birmingham, Veterans Affairs Medical Center, UAB Station, Birmingham, Alabama 35294, USA
    Muscle Nerve 40:795-800. 2009
    ..A randomized, double-blind, cross-over drug trial of 3,4-DAP showed significant efficacy over placebo in patients with LEMS. As a long-term treatment, however, not all patients preferred this drug...
  32. ncbi The first organic-templated vanadyl(IV) gallophosphates with ambient (51)V hyperfine structure, {V(2)Ga(2)O(14)} cluster or heterometal 12-ring channels
    Li Hsun Huang
    Department of Chemistry, National Tsing HuaUniversity, Hsinchu 30013, Taiwan
    Inorg Chem 48:11882-8. 2009
    ..6374(5) A, c = 17.8608(6) A, beta = 97.272(1) degrees , V = 2313.1(1) A(3), and Z = 4; and for 3, monoclinic, P2(1)/c, a = 9.0970(5) A, b = 16.9940(9) A, c = 9.6441(5) A, beta = 103.456(3) degrees , V = 1450.0(1) A(3), and Z = 4...
  33. doi [M(dap)3]InSb3S7 (M = Co, Ni): two novel open-framework thioindate-thioantimonates with 8-, 12-, and 16-ring intersecting channels
    Jian Zhou
    Department of Chemistry and Biology, Yulin Normal University, Yulin 537000, China
    Inorg Chem 50:415-7. 2011
    ..1 and 2 consist of InS4 tetrahedra and SbS3(3-) trigonal pyramids, which are interconnected to form the first examples of three-dimensional In-Sb-S open frameworks with 8-, 12-, and 16-ring intersecting channels. ..
  34. pmc Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
    Xiaoming Wang
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Hum Mol Genet 20:3093-108. 2011
    ..Shank3(e4-9) mice have reduced levels of Homer1b/c, GKAP and GluA1 at the PSD, and show attenuated activity-dependent redistribution of GluA1-containing AMPA receptors...
  35. pmc Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits
    Vesna Boraska
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Am J Med Genet B Neuropsychiatr Genet 159:803-11. 2012
    ..Our study indicates that larger-scale collaborative studies will be needed to achieve the necessary power to detect loci underlying ED-related traits...
  36. pmc GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling
    Seung Min Shin
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Neurosci 15:1655-66. 2012
    ..remodeling of proteins at synapses and synaptic scaling? Here we report that guanylate kinase-associated protein (GKAP; also known as SAPAP), a scaffolding molecule linking NMDA receptor-PSD-95 to Shank-Homer complexes, acts in these ..
  37. pmc Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study
    Ke Wu
    Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Psychiatry Res 211:214-20. 2013
    ..brain volumes and a total of 519 single nucleotide polymorphisms (SNPs) from nine glutamatergic candidate genes (DLGAP1, DLGAP2, DLGAP3, GRIN2B, SLC1A1, GRIK2, GRIK3, SLITRK1 and SLITRK5)...
  38. pmc Systems genetics implicates cytoskeletal genes in oocyte control of cloned embryo quality
    Yong Cheng
    The Fels Institute for Cancer Research and Molecular Biology, Philadelphia, PA 19140, USA
    Genetics 193:877-96. 2013
    ..The major category-including two genes with the strongest genetic associations with the traits (Epb4.1l3 and Dlgap1)-encodes proteins associated with the subcortical cytoskeleton and other cytoskeletal elements such as the spindle...
  39. pmc Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
    C Nagy
    1 McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada 2 Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada
    Mol Psychiatry 20:320-8. 2015
    ....
  40. pmc Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS
    M Mattheisen
    1 Department of Biomedicine and Center for Integrated Sequencing iSEQ, Aarhus University, Aarhus, Denmark 2 Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA 3 Department of Genomic Mathematics, University of Bonn, Bonn, Germany
    Mol Psychiatry 20:337-44. 2015
    ..0176). Secondary analyses of high-confidence interaction partners of DLGAP1 and GRIK2 (both showing evidence for association in our follow-up and the original GWAS study) revealed a trend of ..
  41. doi The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP
    Enora Moutin
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, Montpellier, F 34094, France INSERM, U661, Montpellier, F 34094, France Universités de Montpellier 1 and 2, UMR 5203, Montpellier, F 34094, France
    J Cell Sci 127:3451-62. 2014
    ..two core proteins of the N-methyl-D-aspartate (NMDA)-receptor-associated scaffolding complex, GKAP (also known as DLGAP1) and DLC2 (also known as DYNLL2), using a novel variation of fluorescence fluctuation microscopy called two-photon ..
  42. doi Structure of the GH1 domain of guanylate kinase-associated protein from Rattus norvegicus
    Junsen Tong
    College of Pharmacy, Chonnam National University, Gwangju 500 757, South Korea
    Biochem Biophys Res Commun 452:130-5. 2014
    Guanylate-kinase-associated protein (GKAP) is a scaffolding protein that links NMDA receptor-PSD-95 to Shank-Homer complexes by protein-protein interactions at the synaptic junction...
  43. doi Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development
    Marco Grados
    Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, 1800 Orleans St 12th floor, Baltimore, MD, 21287, USA
    Drug Dev Res 75:372-83. 2014
    ..The OCD susceptibility genes DLGAP1, RYR3, PBX1-MEIS2, LMX1A and candidate genes BDNF and GRIN2B are components of the neuronal growth, ..
  44. pmc Huntingtin-associated protein 1 (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform
    Eleonora Corradini
    From the Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Science Faculty, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands and Netherlands Proteomics Centre, Padualaan 8, 3584 CH Utrecht, The Netherlands
    J Biol Chem 290:7887-96. 2015
    ..Using this approach, we identified Huntingtin-associated protein 1 (HAP1) as a putative novel GKAP. Through sequence alignment with known GKAPs and secondary structure prediction analysis, we defined a small ..
  45. doi N-terminal processing of affinity-tagged recombinant proteins purified by IMAC procedures
    Jane T Mooney
    Centre for Green Chemistry, School of Chemistry, Monash University, Clayton, Victoria, 3800, Australia
    J Mol Recognit 28:401-12. 2015
    ....
  46. pmc Genome-Wide Association Study of HIV-Related Lipoatrophy in Thai Patients: Association of a DLGAP1 Polymorphism with Fat Loss
    Sumonmal Uttayamakul
    1 Bamrasnaradura Infectious Diseases Institute, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand
    AIDS Res Hum Retroviruses 31:792-6. 2015
    ..association of LA with an SNP (rs12964965) in the gene encoding the Disks Large Homolog-Associated Protein 1 (DLGAP1), even after the correction for five multiple comparisons...
  47. pmc Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders
    Jingrui Xing
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 466 8550 Nagoya, Japan
    Sci Rep 6:27491. 2016
    ..We sequenced the protein-encoding regions of DLG1, DLG2, DLG4, DLGAP1, DLGAP2, and SynGAP in 562 cases (370 SZ and 192 ASD patients) on the Ion PGM platform...
  48. doi Room-Temperature Synthesis of Thiostannates from {[Ni(tren)]2[Sn2S6]}n
    Jessica Hilbert
    Institute of Inorganic Chemistry, Christian Albrechts University of Kiel, Max Eyth Str 2, 24118 Kiel, Germany
    Inorg Chem 55:7859-65. 2016
    ..The chemical reactions are fast, and compounds 2 and 3 are formed within 1 h. The synthesis concept presented here opens hitherto unknown possibilities for preparation of new thiostannates. ..
  49. doi Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome
    Jing Li
    Zilkha Neurogenetic Institute, Los Angeles, CA, 90089, USA
    Sci Signal 9:rs8. 2016
    ..Furthermore, the LTP-regulated phosphoproteins, which included the scaffold proteins Shank3, Syngap1, Dlgap1, and Dlg4, represented the "PSD risk" for schizophrenia and autism spectrum disorder, such that without these ..
  50. pmc Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury
    Tayo Katano
    Department of Medical Chemistry, Kansai Medical University, Hirakata 573 1010, Japan
    Eneuro 3:. 2016
    ..These results suggest that BEGAIN was involved in pathological pain transmission through NMDA receptor activation by the phosphorylation of GluN2B at Y1472 in spinal inner lamina II...
  51. pmc Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling
    Tsai Yi Lu
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Commun 8:14355. 2017
    ..Our data argue injury signals received by Draper at the membrane are important regulators of downstream transcriptional responses in reactive glia...
  52. pmc Crystallization and preliminary X-ray crystallographic analysis of the C-terminal domain of guanylate kinase-associated protein from Rattus norvegicus
    Junsen Tong
    College of Pharmacy, Chonnam National University, Gwangju 500 757, Republic of Korea
    Acta Crystallogr F Struct Biol Commun 70:949-54. 2014
    Guanylate kinase-associated protein (GKAP) is a scaffolding protein that plays a role in protein-protein interactions at the synaptic junction such as linking the NMDA receptor-PSD-95 complex to the Shank-Homer complex...
  53. pmc Differential distribution of Shank and GKAP at the postsynaptic density
    Jung Hwa Tao-Cheng
    EM Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 10:e0118750. 2015
    Shank and GKAP are scaffold proteins and binding partners at the postsynaptic density (PSD). The distribution and dynamics of Shank and GKAP were studied in dissociated hippocampal cultures by pre-embedding immunogold electron microscopy...
  54. ncbi Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia
    Yasuo Kajimoto
    Division of Psychiatry and Neurology, Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan
    Neuropsychopharmacology 28:1831-9. 2003
    ..clone obtained was identical to rat synapse-associated protein 90/postsynaptic density-95-associated protein 1 (SAPAP1)...
  55. ncbi Determination of absolute protein numbers in single synapses by a GFP-based calibration technique
    Yoshiko Sugiyama
    Department of Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Nat Methods 2:677-84. 2005
    ..that a single excitatory postsynaptic site contains 100-450 of individual postsynaptic proteins, such as PSD-95, GKAP, Shank and Homer...
  56. ncbi A preformed complex of postsynaptic proteins is involved in excitatory synapse development
    Kimberly Gerrow
    Department of Psychiatry and the Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3
    Neuron 49:547-62. 2006
    ..These mobile clusters contain the scaffolding proteins PSD-95, GKAP, and Shank...
  57. ncbi SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses
    Jaewon Ko
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon 305 701, Korea
    Neuron 50:233-45. 2006
    ..direct aggregation of SALM2 results in coclustering of PSD-95 and other postsynaptic proteins, including GKAP and AMPA receptors...
  58. pmc Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies
    Bing Yu
    Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX, USA
    Circ Cardiovasc Genet 6:82-8. 2013
    ..To date, no large-scale genome-wide association study of hs-cTnT has been reported. We sought to identify novel genetic variants that are associated with hs-cTnT levels...
  59. pmc The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function
    J M Macdonald
    Department of Neurobiology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, MA 01605, USA
    Cell Death Differ 20:1140-8. 2013
    ....
  60. doi Glutamate drugs and pharmacogenetics of OCD: a pathway-based exploratory approach
    Marco A Grados
    Johns Hopkins University School of Medicine, 1800 Orleans St 12th floor, Baltimore, MD 21287, USA 1 443 287 2291 1 410 955 8691
    Expert Opin Drug Discov 8:1515-27. 2013
    ..Concomitantly, there is a growing use of these agents used in the treatment of obsessive-compulsive disorder (OCD)...
  61. doi Purification of a recombinant human growth hormone by an integrated IMAC procedure
    Jane T Mooney
    Centre for Green Chemistry, Building 75, Monash University, Clayton, Victoria 3800, Australia
    Protein Expr Purif 94:85-94. 2014
    ..This study thus documents an integrated approach for the purification of specifically tagged recombinant proteins expressed in genetically modified E. coli. ..
  62. pmc Genome-wide association study of obsessive-compulsive disorder
    S E Stewart
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 18:788-98. 2013
    ..In the case-control analysis, the lowest two P-values were located within DLGAP1 (P=2.49 × 10(-6) and P=3.44 × 10(-6)), a member of the neuronal postsynaptic density complex...
  63. doi Synthesis of Complex Polymeric Telluridoindates from KInTe2
    Johanna Heine
    Fachbereich Chemie and Wissenschaftliches Zentrum für Materialwissenschaften WZMW, Philipps Universitat Marburg, 35037 Marburg, Germany
    Inorg Chem 52:4424-30. 2013
    ....
  64. doi Global profiling of protein kinase activities in cancer cells by mass spectrometry
    Luisa Beltran
    Analytical Signaling Group, Centre for Cell Signaling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Proteomics 77:492-503. 2012
    ..In Global Kinase Activity Profiling (GKAP), protein kinases present in experimental cell lysates phosphorylate endogenous substrates, also present in the ..
  65. doi GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity
    Enora Moutin
    CNRS, UMR 5203, Institut de Genomique Fonctionnelle, F 34000 Montpellier, France
    J Cell Sci 125:2030-40. 2012
    ..a core protein of the glutamatergic receptor postsynaptic scaffold complex, guanylate-kinase-associated protein (GKAP) interacts with dynein light chain 2 (DLC2, also known as DYNLL2), a protein associated with molecular motors...
  66. pmc Daptomycin versus vancomycin in a methicillin-resistant Staphylococcus aureus endophthalmitis rabbit model: bactericidal effect, safety, and ocular pharmacokinetics
    Sophie Lefevre
    Institute of Bacteriology, University of Strasbourg, Strasbourg, France
    Antimicrob Agents Chemother 56:2485-92. 2012
    ..2 mg and 1 mg of daptomycin (DAP 0.2 and DAP 1 groups, respectively) with that of 1 mg of intravitreal vancomycin (VAN 1 group)...
  67. pmc Pattern of deposition of cell wall polysaccharides and transcript abundance of related cell wall synthesis genes during differentiation in barley endosperm
    Sarah M Wilson
    Australian Research Council Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Victoria 3010, Australia
    Plant Physiol 159:655-70. 2012
    ....
  68. doi 1,12-diazaperylene and 2,11-dialkylated-1,12-diazaperylene iridium(III) complexes [Ir(C^N)2(N^N)]PF6: new supramolecular assemblies
    Stefan Kammer
    Universitat Potsdam, Institut fur Chemie, Anorganische Chemie, Potsdam, Germany
    Dalton Trans 41:10219-27. 2012
    ..Thereby, the stability agreed well with the order of the Ir-N(N^N) bond lengths...
  69. pmc Enhancing the promiscuous phosphotriesterase activity of a thermostable lactonase (GkaP) for the efficient degradation of organophosphate pesticides
    Yu Zhang
    State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Appl Environ Microbiol 78:6647-55. 2012
    ..Here, a thermostable PLL from Geobacillus kaustophilus HTA426 (GkaP) was targeted for joint laboratory evolution with the aim of enhancing its catalytic efficiency against OP ..
  70. doi Prostaglandins as negative regulators against lipopolysaccharide, lipoteichoic acid, and peptidoglycan-induced inducible nitric oxide synthase/nitric oxide production through reactive oxygen species-dependent heme oxygenase 1 expression in macrophages
    Chih Chiang Chien
    Division of Nephrology, Chi Mei Medical Center, Tainan, Taiwan
    Shock 38:549-58. 2012
    ..Reactive oxygen species-dependent HO-1 protein expression by PGs, which inhibited LPS-, LTA-, and PGN-induced iNOS/NO production, was identified in macrophages...
  71. pmc Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1
    K K Perkins
    Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley, CA 94720
    EMBO J 7:4265-73. 1988
    ..The Drosophila Jun- and Fos-related antigens, when separated, are individually capable of sequence-specific DNA binding, and the Jun-related antigen activates transcription in vitro...
  72. ncbi Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death
    L P Deiss
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genes Dev 9:15-30. 1995
    ..Altogether, it is suggested that these two novel genes are candidates for positive mediators of programmed cell death that is induced by IFN-gamma...
  73. ncbi Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that interacts directly with postsynaptic density-95/synapse-associated protein 90
    S Naisbitt
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachussetts 02114, USA
    J Neurosci 17:5687-96. 1997
    ..By yeast two-hybrid screening, a novel protein termed guanylate kinase-associated protein (GKAP) has been isolated that binds to the GK-like domain of PSD-95 ()...
  74. ncbi Differential expression of isoforms of PSD-95 binding protein (GKAP/SAPAP1) during rat brain development
    N Kawashima
    Department of Neurochemistry and Neuropharmacology, Biomedical Research Center, Osaka University Medical School, Suita, Japan
    FEBS Lett 418:301-4. 1997
    ..Here we report the isolation of new isoforms of PSD-95 binding protein (GKAP/SAPAP1) using the yeast two-hybrid system...
  75. ncbi Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions
    N Levy-Strumpf
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Oncogene 17:3331-40. 1998
    ....
  76. ncbi In vitro study of molecular weight, hydrophobicity and amino acid composition of peptides during breakdown of a casein hydrolysate by two strains of Prevotella ruminicola
    N Depardon
    Laboratoire des Sciences Animales, Ensais Inra, Vandoeuvre, France
    Reprod Nutr Dev 38:567-76. 1998
    ..ruminicola differed with time and depended on the strain used. The nature of the enzyme activity and the use of other nitrogen sources may explain the difference between the two strains...
  77. ncbi The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis
    M L Liou
    Division of Immunology, Department of Medicine, Cornell University Medical College, New York, New York 10021, USA
    J Biol Chem 274:10145-53. 1999
    ..Collectively, these observations highly suggest a role for DAP-1 in mediating TNF-induced cell death signaling pathways, presumably through the recruitment of FADD death effector...
  78. ncbi Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    J C Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 23:583-92. 1999
    ..clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of ..
  79. ncbi Characterization of the Shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development
    S Lim
    Department of Pharmacology, Pusan National University, Kumjeong Ku, Pusan 609 735, Korea
    J Biol Chem 274:29510-8. 1999
    ..Shank directly interacts with GKAP and Homer, thus potentially bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer ..
  80. ncbi Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family
    T M Boeckers
    Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany
    Biochem Biophys Res Commun 264:247-52. 1999
    ..the PDZ domains of ProSAP1 and 2 as bait in the yeast two-hybrid system, we isolated several clones of the SAPAP/GKAP (SAP90/PSD-95-associated protein/guanylate kinase-associated protein) family...
  81. ncbi Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
    M Passafaro
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 2:1063-9. 1999
    ..the association of PSD-95 with microtubules and inhibited the synaptic clustering of PSD-95, chapsyn-110/PSD-93 and GKAP (a PSD-95-binding protein)...
  82. pmc Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain
    H Hibino
    Departments of Pharmacology II, Graduate School of Medicine, Osaka University, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 19:78-83. 2000
    ..2c channel to G protein stimulation. Furthermore, SAPAP1/GKAP, which binds specifically to the GK domain of membrane-associated guanylate kinases, prevented the SAP97-..
  83. ncbi Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, JCR Pharmaceuticals Company Limited, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 275:2966-72. 2000
    ..S-SCAM, PSD-95/SAP90, and SAPAP are colocalized at least in some part in brain. Therefore, S-SCAM, PSD-95/SAP90, and SAPAP may form a complex in vivo...
  84. ncbi Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments
    K Hirao
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    Genes Cells 5:203-10. 2000
    ..We have further characterized here the Triton X-100-insolubility of SAPAP and tried to identify the Triton X-100-insoluble structures which SAPAP interacts with...
  85. ncbi Radiation exposure of patients and coronary arteries in the stent era: A prospective study
    D Katritsis
    Department of Cardiology, Athens Euroclinic, Athens, Greece
    Catheter Cardiovasc Interv 51:259-64. 2000
    ..Our method can be used for calculation of radiation risk to patients and radiation dose to coronary arteries by using external dosimeters. Cathet. Cardiovasc. Intervent. 51:259-264, 2000...
  86. ncbi The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase
    K Haraguchi
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Genes Cells 5:905-911. 2000
    ..PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP).
  87. ncbi The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif
    K W Lo
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    J Biol Chem 276:14059-66. 2001
    ..The role of each conserved amino acid residue in this pentapeptide motif in supporting complex formation with DLC8 was systematically studied using site-directed mutagenesis...
  88. ncbi Laminar organization of the NMDA receptor complex within the postsynaptic density
    J G Valtschanoff
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 21:1211-7. 2001
    ..The supramolecular organization of these molecules may modulate intracellular transduction of NMDA-mediated signals...
  89. ncbi Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain
    J Fan
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, Kowloon, P R China
    J Mol Biol 306:97-108. 2001
    ..protein designated Bim; a Drosophila RNA localization protein Swallow, myosin V, neuronal scaffolding protein GKAP, and IkappaBalpha, an inhibitor of the NFkappaB transcription factor...
  90. ncbi Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus
    Seong Ho Park
    Department of Life Science, Kwangju Institute of Science and Technology, Gwangju 500 712, South Korea
    Acta Crystallogr D Biol Crystallogr 58:1353-5. 2002
    ..The PDZ domain of Shank binds to the C-terminus of guanylate kinase-associated protein (GKAP)...
  91. ncbi Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97
    Nikolaj Klocker
    Department of Physiology, University of California, San Francisco, CA 94143, USA
    Eur J Neurosci 16:1517-22. 2002
    ..Synaptic clustering of the guanylate kinase domain interacting protein GKAP was also intact...
  92. ncbi Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases
    Olav Olsen
    Department of Physiology and Program in Neuroscience, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Biol Chem 278:6873-8. 2003
    ..Protein ligands for the PSD-95 guanylate kinase domain, guanylate kinase-associated protein (GKAP) and MAP1A, appear not to interact with the canonical GMP binding pocket, and GMP binding does not influence the ..
  93. ncbi Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin
    Shinichi Usui
    Department of Neuroscience D13, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Japan
    J Biol Chem 278:10619-28. 2003
    ..C-terminal leucine zipper motif markedly suppressed the synaptic localization of endogenous shank but not PSD-95 or GKAP. In contrast, an overexpressed GKAP mutant lacking shank binding activity had no effect on the synaptic ..
  94. ncbi Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling
    James G Dobson
    Genomic Physiology Group, Department of Physiology, University of Massachusetts Medical School, Worcester 01655, USA
    Physiol Genomics 15:142-7. 2003
    ..Although these results do not prove causality, they demonstrate that cardiac aging is associated with changes in the profiles of gene expression and that many of these changes may contribute to reduced adrenergic signaling...
  95. ncbi Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse
    Jeffrey M Welch
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 472:24-39. 2004
    ..Furthermore, SAPAP3 mRNA is targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies...
  96. ncbi Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA
    Stefan Kindler
    Institute for Cell Biochemistry and Clinical Neurobiology, University Hospital Hamburg Eppendorf, Hamburg D 20246, Germany
    Brain Res Mol Brain Res 126:14-21. 2004
    The four members of the family of synapse-associated protein 90/postsynaptic density-95-associated proteins (SAPAP1-4) are adapter proteins of postsynaptic density (PSD)...
  97. ncbi Cloning and expression of mars, a novel member of the guanylate kinase associated protein family in Drosophila
    Daimark Bennett
    Department of Zoology, Oxford University, Tinbergen Building, South Parks Road, Oxford OX1 3PS, UK
    Gene Expr Patterns 4:529-35. 2004
    ..Here we describe the identification of Mars, a novel Drosophila protein belonging to the GKAP family...
  98. ncbi A functional role of postsynaptic density-95-guanylate kinase-associated protein complex in regulating Shank assembly and stability to synapses
    Stefano Romorini
    Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology, Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 24:9391-404. 2004
    ..of Shank1 targeting and synapse assembly by looking at the function of guanylate kinase-associated protein (GKAP) and PSD-95 interactions...
  99. ncbi Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes
    Genaro S Scavello
    Division of Ophthalmology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Vis 11:97-110. 2005
    ..31 using 7 families diagnosed with autosomal dominant high myopia and was designated the MYP2 locus. To characterize this region, we analyzed 9 known candidate genes localized to within the 2.2 cM interval by direct sequencing...
  100. pmc p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP
    Guadalupe Sabio
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee, UK
    EMBO J 24:1134-45. 2005
    ..and is targeted to the cytoskeleton by its association with the protein guanylate kinase-associated protein (GKAP)...
  101. ncbi p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins
    Zhang Jing-Ping
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res Mol Brain Res 135:204-16. 2005
    ..assay showed that r-p55 protein interacted with r-p55 itself and various PSD proteins, such as PSD-95, SAP97, GKAP, CASK, GRIP, neuroligin, cadherin, tubulin, actin, alpha-internexin, neurofilament-L and Ca(2+)/calmodulin-..

Research Grants14

  1. Glutamate Receptor Trafficking in Visual Development
    Martha Constantine Paton; Fiscal Year: 2005
    ..trafficking of the NMDA receptor and its mature scaffolding complex, the postsynaptic density proteins PSD-95 and GKAP-95...
  2. Vanilloid Receptor VR1 in Osteoarthritis
    Juli Valtschanoff; Fiscal Year: 2009
    ....
  3. Postsynaptic Protein Trafficking and Synapse Remodeling
    Sang H Lee; Fiscal Year: 2013
    ..Among the activity-regulated proteins, GKAP is one of the major scaffolding proteins in the postsynaptic densities and provides a molecular link for PSD-95/..
  4. Roles of SAPAP Proteins in Synaptic Function and Compulsive-like Behavior
    Guoping Feng; Fiscal Year: 2011
    ..SAPAP family proteins (SAPAP1-4) were originally identified as proteins interacting with PSD95 family and Shank family proteins, two other major ..
  5. CHOEL WOONG KIM; Fiscal Year: 2016
    ..Despite mounting evidence that GKAP target PKGs via its association with the zipper domain, the molecular details of this important protein- protein ..
  6. Modulation and Targeting of Kainate Receptors
    John Marshall; Fiscal Year: 2004
    ..For potential mechanisms, we will examine how binding of ligands, such as GKAP, to the GK domain may promote the association of the SH3 domain of PSD-95 with KA2, the molecular sites on KA2 and ..
  7. CLUSTERING AND TARGETING ION CHANNELS TO THE SYNAPSE
    Vivian Budnik; Fiscal Year: 2002
    ..Studies in mammals have identified a novel protein, GKAP, which interacts with the guanylate kinase domain of the vertebrate MAGUK, PSD-95...
  8. LINKAGE & ASSOCIATION IN OBSESSIVE-COMPULSIVE DISORDER
    Marco Grados; Fiscal Year: 2006
    ..Based on results from initial analyses and developing collaborations with other research groups future research projects, such as a genome-wide screen of OCD, are considered. ..
  9. E3KARP and cGMP regulation of NHE3
    Mark Donowitz; Fiscal Year: 2003
    ..whether it acts as a scaffold to assemble a signaling complex that includes NHE3 and cGMP kinase II and to determine whether E3KARP is the first identified functionally important cGMP kdnase II Anchoring Protein (GKAP).
  10. ADENOSINE A1 AND A2 RECEPTORS IN THE MYOCARDIUM
    James Dobson; Fiscal Year: 2004
    ..Additionally, the findings should significantly contribute to our basic knowledge of the molecular mechanisms of G protein coupled receptor cross-regulation in the heart. ..
  11. Vanilloid Receptors in Nociception
    Juli Valtschanoff; Fiscal Year: 2004
    ..abstract_text> ..
  12. Light activated bioactive substrate release
    RICHARD GIVENS; Fiscal Year: 2008
    ..abstract_text> ..
  13. Myocardial Adenosine Receptors
    James G Dobson; Fiscal Year: 2010
    ..Such information should be instrumental for the development of new therapies and agents to alleviate cardiac dysfunction. ..