DLG2

Summary

Gene Symbol: DLG2
Description: discs, large homolog 2 (Drosophila)
Alias: PPP1R58, PSD-93, PSD93, chapsyn-110, channel-associated protein of synapse-110, channel-associated protein of synapses, 110kDa, discs large 2, discs, large homolog 2, chapsyn-110, disks large homolog 2, postsynaptic density protein PSD-93, protein phosphatase 1, regulatory subunit 58
Species: human

Top Publications

  1. ncbi Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK
    Kai Schuh
    Department of Medicine, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Biol Chem 278:9778-83. 2003
  2. ncbi Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif
    Chunlin Cai
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 277:31484-90. 2002
  3. ncbi SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit
    A S Leonard
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:19518-24. 1998
  4. pmc The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
    R A Garcia
    Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3596-601. 2000
  5. ncbi Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95
    Heike Hering
    Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
    FEBS Lett 521:185-9. 2002
  6. ncbi Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 17:103-13. 1996
  7. ncbi PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
  8. ncbi Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
    James H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:75-93. 2003
  9. ncbi Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases
    Jeonghoon Choi
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 25:869-79. 2005
  10. ncbi Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosets
    M J Hurley
    Neurodegenerative Diseases Research Group, Pharmaceutical Sciences Division, School of Health and Life Sciences, King s College, London, SE1 1UL, UK
    Eur J Neurosci 21:3240-50. 2005

Research Grants

  1. Olivocerebellar Circuitry in Autism
    Gene J Blatt; Fiscal Year: 2010
  2. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
  3. Interaction of Anesthetics with Neuronal PDZ Domains
    Roger Johns; Fiscal Year: 2009
  4. Role of Spinal Cord PSD-93/Chapsyn-110 in Chronic Pain
    Roger Johns; Fiscal Year: 2007
  5. SYNAPTIC REGULATION OF NITRIC OXIDE
    David Bredt; Fiscal Year: 2005
  6. Modulation of parasympathetic neurons by PACAP peptides
    RODNEY PARSONS; Fiscal Year: 2005
  7. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
  8. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
  9. NR3 Expression in Human Brain
    Helena Mueller; Fiscal Year: 2003
  10. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK
    Kai Schuh
    Department of Medicine, University of Wuerzburg, D 97080 Wuerzburg, Germany
    J Biol Chem 278:9778-83. 2003
    ..In particular, SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bind to the C-terminal tails of PMCA "b" splice variants...
  2. ncbi Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif
    Chunlin Cai
    Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 277:31484-90. 2002
    ....
  3. ncbi SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit
    A S Leonard
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:19518-24. 1998
    ..Our findings suggest that SAP97 may be involved in localizing AMPA receptors at postsynaptic sites through its interaction with the GluR1 subunit...
  4. pmc The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
    R A Garcia
    Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:3596-601. 2000
    ..As discussed, the interactions found between receptor tyrosine kinases and MAGUKs at neuronal synapses may have important implications for activity-dependent plasticity...
  5. ncbi Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95
    Heike Hering
    Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
    FEBS Lett 521:185-9. 2002
    ....
  6. ncbi Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins
    E Kim
    Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 17:103-13. 1996
    ..Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins...
  7. ncbi PSD93 regulates synaptic stability at neuronal cholinergic synapses
    Michael J Parker
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:378-88. 2004
    ..We find that novel splicing forms of PSD93 (postsynaptic density 93) are expressed in SCG...
  8. ncbi Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
    James H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:75-93. 2003
    ..for a given glutamate receptor subtype, the most well characterized being the NMDA receptor binding proteins PSD93, PSD95, NF-L, and SAP102...
  9. ncbi Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases
    Jeonghoon Choi
    National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    J Neurosci 25:869-79. 2005
    ..These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis...
  10. ncbi Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosets
    M J Hurley
    Neurodegenerative Diseases Research Group, Pharmaceutical Sciences Division, School of Health and Life Sciences, King s College, London, SE1 1UL, UK
    Eur J Neurosci 21:3240-50. 2005
    ..These results suggest that l-DOPA treatment of MPTP-lesioned marmosets can affect glutamatergic systems and indicate that altered NMDA receptor function may relate to dyskinesia...
  11. pmc In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93
    Ilse Delint-Ramirez
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    J Neurosci 30:8162-70. 2010
    ..These data show critical roles for scaffold proteins and their interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes...
  12. ncbi Interactions between Src family protein tyrosine kinases and PSD-95
    Lorraine V Kalia
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario M5G 1X8, Canada
    Neuropharmacology 45:720-8. 2003
    ..Together our results suggest that PSD-95 may be important for localizing and/or regulating multiple Src protein tyrosine kinases at the NMDA receptor multiprotein complex...
  13. ncbi Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury
    Bosheng Zhang
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
    Pain 106:187-96. 2003
    ..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain...
  14. ncbi Improved immunohistochemical detection of postsynaptically located PSD-95/SAP90 protein family by protease section pretreatment: a study in the adult mouse brain
    M Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Comp Neurol 426:572-86. 2000
    ..Consequently, the present immunohistochemical results have provided light microscopic evidence supporting the prevailing notion that the PSD-95/SAP90 protein family interacts with NMDA receptor subunits and potassium channel subunits...
  15. pmc Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity
    Holly J Carlisle
    Department of Physiology, David Geffen School of Medicine at UCLA, 53 231 Center for the Health Sciences, Box 951751, Los Angeles, CA 90095 1751, USA
    J Physiol 586:5885-900. 2008
    ....
  16. ncbi Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling
    Jesús F Torres-Peraza
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
    Neurobiol Dis 29:409-21. 2008
    ..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1...
  17. ncbi A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A
    S Mazoyer
    CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, United Kingdom
    Genomics 28:25-31. 1995
    ..and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors...
  18. doi Tumor suppressor CADM1 is involved in epithelial cell structure
    Mika Sakurai-Yageta
    Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 390:977-82. 2009
    ..Here, we demonstrate that MPP1/p55 and MPP2/DLG2, as well as MPP3, interact with both CADM1 and 4.1B, forming a tripartite complex...
  19. ncbi Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia
    L V Kristiansen
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Mol Psychiatry 11:737-47, 705. 2006
    ..Our findings suggest abnormal regional processing of the NMDA receptor and its associated PSD molecules, possibly involving transcription, translation, trafficking and protein stability in cortical areas in schizophrenia...
  20. ncbi Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression
    Lars V Kristiansen
    Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Schizophr Res 78:87-93. 2005
    ....
  21. ncbi Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortex
    C Aoki
    Center for Neural Science, New York University, New York, New York 10003, USA
    Synapse 40:239-57. 2001
    ..These results suggest that MAGUKs have dual roles: to maintain receptors at synapses and to regulate shuttling of receptors between nonsynaptic and synaptic sites...
  22. ncbi Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses
    K W Roche
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 19:3926-34. 1999
    ....
  23. ncbi Phosphoproteomic analysis of synaptosomes from human cerebral cortex
    Joseph A DeGiorgis
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 4:306-15. 2005
    ..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes...
  24. pmc NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus
    Rana A Al-Hallaq
    Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 27:8334-43. 2007
    ..In summary, in rat hippocampus, NR2A and NR2B exist primarily in di-heteromeric complexes that interact similarly with PSD-95-related proteins but are associated with different protein complexes...
  25. doi Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy
    Monica Fiorentini
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Crystallogr D Biol Crystallogr 69:587-94. 2013
    PSD-93 (chapsyn-110, DLG2) is a member of the family of membrane-associated guanylate kinase (MAGUK) proteins. The MAGUK proteins are involved in receptor localization and signalling pathways...
  26. pmc Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission
    Juliane M Krüger
    European Neuroscience Institute, 37077 Gottingen, Germany, Göttingen Graduate School for Neurosciences and Molecular Biosciences, 37077 Gottingen, Germany, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany, International Max Planck Research School for Neuroscience, 37077 Gottingen, Germany, Bioanalytics, Department of Clinical Chemistry, 37075 Gottingen, Germany, and Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260
    J Neurosci 33:15504-17. 2013
    ..Collectively, these results demonstrate that alternative combinations of N-terminal PSD-93 isoforms and DLG-MAGUK paralogs can fine-tune signaling scaffolds to adjust synaptic needs to regulate synaptic transmission. ..
  27. pmc High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling
    Yang Yang
    Key Laboratory of Neurological Disease, Ministry of Education, China
    PLoS ONE 8:e55384. 2013
    ....
  28. pmc Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicity
    M Zhang
    Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China
    Neuroscience 166:1083-90. 2010
    ..Since NMDARs, Ca(2+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders...
  29. ncbi Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteins
    Guillermo M Elias
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 52:307-20. 2006
    ..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
  30. ncbi Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein
    Yuan Xiang Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 23:6703-12. 2003
    ..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
  31. ncbi Characterization of zebrafish PSD-95 gene family members
    Martin P Meyer
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305, USA
    J Neurobiol 63:91-105. 2005
    ..These data are consistent with the idea that PSD-95 family members are involved in synapse assembly and function, and provide a platform for future functional studies in vivo in a highly tractable model organism...
  32. ncbi Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins
    Dmitri Leonoudakis
    Department of Molecular, Cellular, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 279:22331-46. 2004
    ..We identified eight members of the MAGUK family of proteins (SAP97, PSD-95, Chapsyn-110, SAP102, CASK, Dlg2, Dlg3, and Pals2), two isoforms of Veli (Veli-1 and Veli-3), Mint1, and actin-binding LIM protein (abLIM) as Kir2...
  33. ncbi Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cells
    T Claudepierre
    INSERM EMI 99 18, Laboratoire de Physiopathologie Moléculaire et Cellulaire de la Rétine, CHRU, France
    J Cell Sci 113:3409-17. 2000
    ....
  34. ncbi [MAGUKs: beyond ionic channel anchoring]
    David Godreau
    INSERM U 460, Batiment 13, CHU Xavier Bichat Claude Bernard, 46, rue Henri Huchard, 75877 Paris 18, France
    Med Sci (Paris) 20:84-8. 2004
    ..In the heart also, MAGUK proteins are abundantly expressed and they interact with various channels including Shaker Kv1.5 and connexins...
  35. doi Research progress on neurobiology of neuronal nitric oxide synthase
    Chun Xia Luo
    Department of Pharmacology, School of Pharmacy, Laboratory of Cerebrovascular Disease, Nanjing Medical University, Nanjing 210029, China
    Neurosci Bull 27:23-35. 2011
    ..leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and ..
  36. ncbi Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina
    P Koulen
    , D 60528 Frankfurt, Germany
    J Neurosci 18:10136-49. 1998
    ..Double-labeling experiments also were performed for PSD-95 and for the NR1 subunit of the NMDA receptor. They were found to be colocalized in synaptic hot spots in the IPL...
  37. pmc Interactions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK)
    Ming Lei Guo
    Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Brain Res 1465:18-25. 2012
    ..Our data provide evidence supporting PSD-93 as a new substrate of the synaptic species of ERK. ERK2 possesses the ability to interact with PSD-93 and phosphorylate PSD-93 at a specific site...
  38. pmc A genome-wide association study identifies susceptibility loci for Wilms tumor
    Clare Turnbull
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Nat Genet 44:681-4. 2012
    ..32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22...
  39. pmc Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse
    Majid Nikpay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertens Res 35:585-91. 2012
    ..numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic function and ..
  40. pmc Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retina
    Salvatore L Stella
    Department of Ophthalmology, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri, United States of America
    PLoS ONE 7:e43463. 2012
    ..These findings provide convincing evidence for Shank 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95/Shank 1 complexes at cone synapses in the outer retina...
  41. ncbi Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins
    S J DeMarco
    Program in Molecular Neuroscience, Department of Biochemistry, Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Biol Chem 276:21594-600. 2001
    ..The related MAGUKs SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bound to the COOH-terminal tail of PMCA4b, whereas only the first three bound ..
  42. pmc Synaptic scaffold evolution generated components of vertebrate cognitive complexity
    Jess Nithianantharajah
    Genes to Cognition Programme, Centre for Clinical Brain Sciences and Centre for Neuroregeneration, The University of Edinburgh, Edinburgh, UK
    Nat Neurosci 16:16-24. 2013
    ..carrying mutations in each of the four Dlg paralogs showed that simple associative learning required Dlg4, whereas Dlg2 and Dlg3 diversified to have opposing functions in complex cognitive processes...
  43. doi The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteins
    Sally Roberts
    School of Cancer Sciences, University of Birmingham, UK
    FEBS J 279:3549-58. 2012
    ..However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known...
  44. pmc Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects
    Vanja Duric
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Int J Neuropsychopharmacol 16:69-82. 2013
    ..Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and ..
  45. ncbi Interaction of brain somatostatin receptors with the PDZ domains of PSD-95
    Marcus Christenn
    Institut fur Zellbiochemie und klinische Neurobiologie, Martinistrasse 52, 20246 Hamburg, Germany
    FEBS Lett 581:5173-7. 2007
    ..As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites...
  46. ncbi PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors
    Hong Cui
    NoNO Inc, Toronto, Ontario, Canada M8X 1R5
    J Neurosci 27:9901-15. 2007
    ..Consequently, PSD-95 inhibition may constitute a highly specific strategy for treating excitotoxic disorders...
  47. pmc Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation
    Sabine Lindquist
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 6:e23978. 2011
    ..kinase activity is now reduced (-20-30%), pointing to the development of a compensatory mechanism that may involve PSD93. The distribution of the Csk-homologous kinase CHK is not altered...
  48. doi Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in mice
    Feng Tao
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Anesthesiology 112:1444-51. 2010
    ....
  49. pmc Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina
    Jun Zhang
    Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 29:4274-86. 2009
    ....
  50. ncbi The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slices
    Kazuhisa Kohda
    Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Eur J Neurosci 25:1357-62. 2007
    ..Together, these results indicate that PDZ proteins that bind to the C-terminus of GluRdelta2 are not essential for localizing GluRdelta2 at synapses but are crucial for conveying signals necessary for the induction of LTD...
  51. pmc Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions
    Jonathan M Elkins
    Structural Genomics Consortium, Oxford University, Botnar Research Centre, Oxford, OX3 7LD, United Kingdom
    Protein Sci 16:683-94. 2007
    ..using this approach and focus on four which provide information on selectivity (PICK1 and the third PDZ domain of DLG2), binding site flexibility (the third PDZ domain of MPDZ), and peptide-domain interactions (MPDZ 12th PDZ domain)...
  52. pmc Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, CIRC 576A 0021, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Brain Res 1127:108-18. 2007
    ..proteins critical for NMDA receptor assembly, trafficking, and activation; the most well-characterized being PSD93, PSD95, SAP102, and NF-L...
  53. ncbi Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
    Ling Qiang Zhu
    Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
    J Neurosci 27:12211-20. 2007
    ..In postsynaptic level, the expression of PSD93 and NR2A/B proteins decreased significantly when GSK-3 was activated...
  54. pmc PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down
    Qian Sun
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 31:6800-8. 2011
    ....
  55. pmc Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro
    Erik J MacLaren
    Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
    Mol Cell Neurosci 47:93-9. 2011
    ..Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene...
  56. pmc Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons
    Ido Horresh
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 28:14213-22. 2008
    ..This mechanism is clearly distinct from the one operating at the axon initial segment, which requires PSD-93 for Kv1 channel clustering...
  57. pmc Structure of the first PDZ domain of human PSD-93
    Monica Fiorentini
    Biostructural Research, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1254-7. 2009
    ..However, the cleft is significantly narrower in PSD-95. This could be part of the basis of peptide selectivity between PSD-93 PDZ1 and PSD-95 PDZ1...
  58. pmc ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 30:1038-48. 2010
    ..2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes...
  59. pmc Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 28:5731-9. 2008
    ..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
  60. pmc Post-synaptic density-93 mediates tyrosine-phosphorylation of the N-methyl-D-aspartate receptors
    Y Sato
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroscience 153:700-8. 2008
    ..Our findings indicate that PSD-93 appears to mediate tyrosine-phosphorylation of the NMDA receptors and synaptic localization of Fyn...
  61. doi Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDs
    Joseph A DeGiorgis
    Laboratory of Neurobiology, National Institutes of Health, NINDS, Building 49, Room 3A60, 49 Convent Drive, Bethesda, MD 20892, USA
    Brain Cell Biol 35:239-50. 2006
    ..The distribution of SAP97 confirms that this protein is actually an integral component of the PSD, and suggests that it may have a role in inserting or stabilizing its main binding partner, Glu-R1, at the edge of the PSD...
  62. doi Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins
    Sarah L Cousins
    School of Pharmacy, University of London, London, UK
    J Neurochem 104:903-13. 2008
    ..This has implications for the stabilisation, turnover and compartmentalisation of NMDA receptor subtypes in neurones during development and in the mature brain...
  63. pmc The role of SAP97 in synaptic glutamate receptor dynamics
    MacKenzie A Howard
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:3805-10. 2010
    ..However, due to functional redundancy, other PSD-MAGUKs can presumably compensate when SAP97 is conditionally deleted during development...
  64. pmc SAP102 is a highly mobile MAGUK in spines
    Chan Ying Zheng
    Laboratories of Neurochemistry and Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 30:4757-66. 2010
    ..These differences and the compensatory properties of the MAGUKs point out an unrecognized versatility of the MAGUKs in their function in synaptic organization and plasticity...
  65. pmc The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo
    Madelaine M Rosenberg
    Department of Neuroscience, Tufts University, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
    J Neurosci 30:11073-85. 2010
    ..APC human gene mutations correlate with autism spectrum disorders, providing strong support for the importance of the association, demonstrated here, between APC, neuroligin and neurexin...
  66. ncbi Non-random inactivation of large common fragile site genes in different cancers
    S McAvoy
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Cytogenet Genome Res 118:260-9. 2007
    ..cancers, we examined the expression of 13 of the 20 known large CFS genes: FHIT, WWOX, PARK2, GRID2, NBEA, DLG2, RORA isoforms 1 and 4, DAB1, CNTNAP2, DMD, IL1RAPL1, IMMP2L and LARGE in breast, ovarian, endometrial and brain ..
  67. pmc Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26
    Ziad J Sahab
    1 Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Department of Oncology, Washington, DC, 20007, USA
    J Cancer 1:14-22. 2010
    ....
  68. pmc Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortex
    Gulcan Akgul
    State University of New York at Stony Brook, 11794 5230, USA
    J Comp Neurol 518:4842-54. 2010
    ....
  69. pmc Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 protein
    Wen Jinn Liaw
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Pain 4:45. 2008
    ..The selective effect of PSD-93 deletion on synaptic NMDAR expression in these two major pain-related regions might provide the better strategies for the prevention and treatment of opioid tolerance and physical dependence...
  70. ncbi Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain
    Fang Deng
    Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:7875-84. 2006
    ..These experiments identify MAGI-2 as a strong candidate for linking TARP/AMPA receptor complexes to a wide range of other postsynaptic molecules and pathways and advance our knowledge of protein interactions at mammalian CNS synapses...
  71. ncbi Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21
    S A Smith
    Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
    Genomics 31:145-50. 1996
    ..The DLG3 gene is located on chromosome 17, in the same segment, 17q12-q21, as the related gene, DLG2. The products of the DLG2 and DLG3 genes show 36% identity and 58% similarity to each other, and both show nearly ..
  72. ncbi Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes
    M Russwurm
    Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
    J Biol Chem 276:44647-52. 2001
    ....
  73. ncbi PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum
    A W McGee
    Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
    J Neurosci 21:3085-91. 2001
    ..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity...
  74. ncbi Enrichment of N-methyl-D-aspartate NR1 splice variants and synaptic proteins in rat postsynaptic densities
    R A Al-Hallaq
    Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington DC 20007, USA
    J Neurochem 77:110-9. 2001
    ..Thus, although postsynaptic densities are highly enriched in synaptic proteins, there appears to be no selective incorporation of specific NR1 splice variants or NR2 subunits into this structure...
  75. ncbi Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95
    S Inagaki
    Group of Neurobiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Yamadaoka 1 7, Suita Shi, Osaka, 565 0871, Japan
    J Biol Chem 276:9174-81. 2001
    ..In neocortical culture, S4C is colocalized with PSD-95 in neurons, with a dot-like pattern along the neurites. Sema4C thus may function in the cortical neurons as a bi-directional transmembrane ligand through interacting with PSD-95...
  76. ncbi The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase
    K Haraguchi
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Japan
    Genes Cells 5:905-911. 2000
    ..PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP)...
  77. ncbi Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains
    B L Firestein
    Department of Physiology, University of California at San Francisco, 94143 0444, USA
    Neuroreport 11:3479-84. 2000
    ..These results suggest that MAGUKs contain diverse signals within their N-termini for postsynaptic targeting...
  78. ncbi Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95
    M Passafaro
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
    Nat Neurosci 2:1063-9. 1999
    ..However, the number of synapses and the synaptic clustering of NMDA receptors were unaffected, suggesting that PSD-95-family proteins are not essential for the maintenance of synapses and the synaptic localization of NMDA receptors...
  79. ncbi Localization of synapse-associated proteins during postnatal development of the rat retina
    P Koulen
    Max Planck Institut für Hirnforschung, Abteilung fur Neuroanatomie, Frankfurt am Main, Germany
    Eur J Neurosci 11:2007-18. 1999
    ..Possible functions of the early expression of SAPs well before differentiation and maturation of glutamatergic ribbon synapses are discussed...
  80. ncbi Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brain
    M Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    Neurosci Res 33:111-8. 1999
    ....
  81. ncbi Interaction of neuronal nitric-oxide synthase with alpha1-syntrophin in rat brain
    A Hashida-Okumura
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 274:11736-41. 1999
    ..These results indicate that nNOS in brain interacts with alpha1-syntrophin in specific neurons of the SCN and paraventricular nucleus and that this interaction might play a physiological role in functions of these neurons...
  82. ncbi Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs
    S E Craven
    Department of Physiology and Program in Neuroscience, University of California, San Francisco 94143 0444, USA
    Neuron 22:497-509. 1999
    ..The requirements for PDZ domains and a C-terminal domain of PSD-95 indicate that protein-protein interactions cooperate with lipid interactions in synaptic targeting...
  83. ncbi Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
    E Kim
    Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
    Nature 378:85-8. 1995
    ..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
  84. ncbi Localization of Dlg at the mammalian neuromuscular junction
    J A Rafael
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neuroreport 9:2121-5. 1998
    ..Dlg may therefore be important for establishing or maintaining the organization of protein complexes at the mammalian NMJ...
  85. ncbi Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
    J E Brenman
    Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
    Cell 84:757-67. 1996
    ..Interaction of PDZ-containing domains therefore mediates synaptic association of nNOS and may play a more general role in formation of macromolecular signaling complexes...
  86. ncbi Binding of neuroligins to PSD-95
    M Irie
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2 2 10, Murotani, Nishi ku, Kobe, 651 22, Japan
    Science 277:1511-5. 1997
    ..Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins...
  87. ncbi Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein
    J E Brenman
    Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
    J Neurosci 16:7407-15. 1996
    ....
  88. ncbi Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses
    Atsushi Inanobe
    Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Am J Physiol Cell Physiol 282:C1396-403. 2002
    ..Therefore, the Kir channel may be involved in formation of the resting membrane potential of the spines and, thus, would affect the response of N-methyl-D-aspartic acid receptor channels at the excitatory postsynaptic membrane...
  89. ncbi An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1
    Mark L Leyland
    Department of Biochemistry, University of Leicester, PO Box 138, LE1 9HN, UK
    J Biol Chem 279:43427-36. 2004
    ..1 clustering and suppression of channel internalization. We conclude that PSD-93delta is potentially an important regulator of the spatial and temporal distribution of Kir2 channels within neuronal membranes of the central nervous system...
  90. ncbi Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    Helena T Mueller
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Brain Res Mol Brain Res 121:60-9. 2004
    ..These data support the hypothesis that schizophrenia may involve alterations in dopamine-glutamate interactions...
  91. pmc Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects
    Rineke Steenbergen
    Canadian Institutes for Health Research Group on the Molecular and Cell Biology of Lipids and Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 280:40032-40. 2005
    ..Moreover, elimination of PE production in mitochondria causes fragmented, misshapen mitochondria, an abnormality that likely contributes to the embryonic lethality...
  92. ncbi Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95
    Mio Nonaka
    Department of Biophysics, Kyoto University Graduate School of Science, Kyoto 606 8502, Japan
    J Neurosci 26:763-74. 2006
    ....
  93. ncbi Control of synaptic connection by glutamate receptor delta2 in the adult cerebellum
    Tomonori Takeuchi
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Tokyo 113 0033, Japan
    J Neurosci 25:2146-56. 2005
    ..We thus identified postsynaptic GluRdelta2 as a key regulator of the presynaptic active zone and PSD organization at parallel fiber-PC synapses in the adult brain...
  94. ncbi Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn
    Shigeyuki Nada
    Department of Oncogene Research, Research Institute for Microbial Disease, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:47610-21. 2003
    ..These results suggest that PSD-93 serves as a membrane-anchored substrate of Fyn and plays a role in the regulation of Fyn-mediated modification of NMDA receptor function...
  95. ncbi Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb
    Marco Sassoè-Pognetto
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, I 10126 Torino, Italy
    J Comp Neurol 463:237-48. 2003
    ..The latter molecules appear to be expressed in an all-or-none fashion and may form a standard lattice common to different types of glutamatergic synapse...
  96. ncbi Protein 4.1-mediated membrane targeting of human discs large in epithelial cells
    Toshihiko Hanada
    Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 278:34445-50. 2003
    ..introduced a double mutation (I38A/I40A) into the N-terminal domain of hDlg, which disrupted its interaction with DLG2, a key event in the membrane targeting of hDlg...
  97. ncbi Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
    Am J Psychiatry 160:1100-9. 2003
    ..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
  98. ncbi Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression
    Gabriela Lavezzari
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5B20, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Neuropharmacology 45:729-37. 2003
    ....
  99. ncbi Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium
    David Godreau
    INSERM Unité 460, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    Cardiovasc Res 56:433-42. 2002
    ..Here, we studied the expression and role of these anchoring proteins in human right atrial myocardium by means of various molecular, biochemical and physiological methods...
  100. pmc Differential expression of a new isoform of DLG2 in renal oncocytoma
    Dmitry Zubakov
    Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 6:106. 2006
    ..Therefore, identification of molecular markers would be of great value for molecular diagnostics of this tumour type...
  101. ncbi Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    Kazuhiko Toyooka
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 83:797-806. 2002
    ..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...

Research Grants10

  1. Olivocerebellar Circuitry in Autism
    Gene J Blatt; Fiscal Year: 2010
    ..Co-localization of GluRo2 with PSD93 will determine the percentage of postsynaptic density and co-localization of EAAT4 with synaptophysin will ..
  2. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..Further, the studies will determine whether the organizational mechanisms are shared between peripheral neuron and central sensory nicotinic synapses. ..
  3. Interaction of Anesthetics with Neuronal PDZ Domains
    Roger Johns; Fiscal Year: 2009
    ....
  4. Role of Spinal Cord PSD-93/Chapsyn-110 in Chronic Pain
    Roger Johns; Fiscal Year: 2007
    ..These studies will provide a novel insight to the mechanisms of chronic pain and a new and potential biochemical target for the prevention and therapy of chronic pain. [unreadable] [unreadable]..
  5. SYNAPTIC REGULATION OF NITRIC OXIDE
    David Bredt; Fiscal Year: 2005
    ..On the other hand, an extended "P-finger" of the NNOS PDZ domain binds to PSD-95 and PSD-93, postsynaptic density proteins that mediate synaptic clustering of NMDA receptors. ..
  6. Modulation of parasympathetic neurons by PACAP peptides
    RODNEY PARSONS; Fiscal Year: 2005
    ....
  7. CENTER FOR NEUROSCIENCE EXCELLENCE
    Rodney L Parsons; Fiscal Year: 2010
    ....
  8. Chemically specified synaptogenesis in the visual cortex
    Chiye Aoki; Fiscal Year: 2004
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
  9. NR3 Expression in Human Brain
    Helena Mueller; Fiscal Year: 2003
    ..abstract_text> ..
  10. SYNAPTOGENESIS IN THE CEREBRAL CORTEX
    Chiye Aoki; Fiscal Year: 2003
    ..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..