Genomes and Genes
Gene Symbol: DLG2
Description: discs, large homolog 2 (Drosophila)
Alias: PPP1R58, PSD-93, PSD93, chapsyn-110, channel-associated protein of synapse-110, channel-associated protein of synapses, 110kDa, discs large 2, discs, large homolog 2, chapsyn-110, disks large homolog 2, postsynaptic density protein PSD-93, protein phosphatase 1, regulatory subunit 58
Publications115 found, 100 shown here
- Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASKKai Schuh
Department of Medicine, University of Wuerzburg, D 97080 Wuerzburg, Germany
J Biol Chem 278:9778-83. 2003..In particular, SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bind to the C-terminal tails of PMCA "b" splice variants...
- Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motifChunlin Cai
Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki FIN 00014, Finland
J Biol Chem 277:31484-90. 2002....
- SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunitA S Leonard
Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
J Biol Chem 273:19518-24. 1998..Our findings suggest that SAP97 may be involved in localizing AMPA receptors at postsynaptic sites through its interaction with the GluR1 subunit...
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapsesR A Garcia
Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:3596-601. 2000..As discussed, the interactions found between receptor tyrosine kinases and MAGUKs at neuronal synapses may have important implications for activity-dependent plasticity...
- Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95Heike Hering
Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
FEBS Lett 521:185-9. 2002....
- Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteinsE Kim
Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
Neuron 17:103-13. 1996..Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins...
- PSD93 regulates synaptic stability at neuronal cholinergic synapsesMichael J Parker
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:378-88. 2004..We find that novel splicing forms of PSD93 (postsynaptic density 93) are expressed in SCG...
- Molecular abnormalities of the glutamate synapse in the thalamus in schizophreniaJames H Meador-Woodruff
Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Ann N Y Acad Sci 1003:75-93. 2003..for a given glutamate receptor subtype, the most well characterized being the NMDA receptor binding proteins PSD93, PSD95, NF-L, and SAP102...
- Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPasesJeonghoon Choi
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 25:869-79. 2005..These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis...
- Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosetsM J Hurley
Neurodegenerative Diseases Research Group, Pharmaceutical Sciences Division, School of Health and Life Sciences, King s College, London, SE1 1UL, UK
Eur J Neurosci 21:3240-50. 2005..These results suggest that l-DOPA treatment of MPTP-lesioned marmosets can affect glutamatergic systems and indicate that altered NMDA receptor function may relate to dyskinesia...
- In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93Ilse Delint-Ramirez
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
J Neurosci 30:8162-70. 2010..These data show critical roles for scaffold proteins and their interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes...
- Interactions between Src family protein tyrosine kinases and PSD-95Lorraine V Kalia
Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario M5G 1X8, Canada
Neuropharmacology 45:720-8. 2003..Together our results suggest that PSD-95 may be important for localizing and/or regulating multiple Src protein tyrosine kinases at the NMDA receptor multiprotein complex...
- Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injuryBosheng Zhang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
Pain 106:187-96. 2003..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain...
- Improved immunohistochemical detection of postsynaptically located PSD-95/SAP90 protein family by protease section pretreatment: a study in the adult mouse brainM Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
J Comp Neurol 426:572-86. 2000..Consequently, the present immunohistochemical results have provided light microscopic evidence supporting the prevailing notion that the PSD-95/SAP90 protein family interacts with NMDA receptor subunits and potassium channel subunits...
- Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticityHolly J Carlisle
Department of Physiology, David Geffen School of Medicine at UCLA, 53 231 Center for the Health Sciences, Box 951751, Los Angeles, CA 90095 1751, USA
J Physiol 586:5885-900. 2008....
- Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signalingJesús F Torres-Peraza
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Neurobiol Dis 29:409-21. 2008..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1...
- A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-AS Mazoyer
CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, United Kingdom
Genomics 28:25-31. 1995..and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors...
- Tumor suppressor CADM1 is involved in epithelial cell structureMika Sakurai-Yageta
Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
Biochem Biophys Res Commun 390:977-82. 2009..Here, we demonstrate that MPP1/p55 and MPP2/DLG2, as well as MPP3, interact with both CADM1 and 4.1B, forming a tripartite complex...
- Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophreniaL V Kristiansen
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
Mol Psychiatry 11:737-47, 705. 2006..Our findings suggest abnormal regional processing of the NMDA receptor and its associated PSD molecules, possibly involving transcription, translation, trafficking and protein stability in cortical areas in schizophrenia...
- Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depressionLars V Kristiansen
Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Schizophr Res 78:87-93. 2005....
- Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortexC Aoki
Center for Neural Science, New York University, New York, New York 10003, USA
Synapse 40:239-57. 2001..These results suggest that MAGUKs have dual roles: to maintain receptors at synapses and to regulate shuttling of receptors between nonsynaptic and synaptic sites...
- Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapsesK W Roche
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 19:3926-34. 1999....
- Phosphoproteomic analysis of synaptosomes from human cerebral cortexJoseph A DeGiorgis
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 4:306-15. 2005..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes...
- NMDA di-heteromeric receptor populations and associated proteins in rat hippocampusRana A Al-Hallaq
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:8334-43. 2007..In summary, in rat hippocampus, NR2A and NR2B exist primarily in di-heteromeric complexes that interact similarly with PSD-95-related proteins but are associated with different protein complexes...
- Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopyMonica Fiorentini
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Acta Crystallogr D Biol Crystallogr 69:587-94. 2013PSD-93 (chapsyn-110, DLG2) is a member of the family of membrane-associated guanylate kinase (MAGUK) proteins. The MAGUK proteins are involved in receptor localization and signalling pathways...
- Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmissionJuliane M Krüger
European Neuroscience Institute, 37077 Gottingen, Germany, Göttingen Graduate School for Neurosciences and Molecular Biosciences, 37077 Gottingen, Germany, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany, International Max Planck Research School for Neuroscience, 37077 Gottingen, Germany, Bioanalytics, Department of Clinical Chemistry, 37075 Gottingen, Germany, and Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260
J Neurosci 33:15504-17. 2013..Collectively, these results demonstrate that alternative combinations of N-terminal PSD-93 isoforms and DLG-MAGUK paralogs can fine-tune signaling scaffolds to adjust synaptic needs to regulate synaptic transmission. ..
- High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signalingYang Yang
Key Laboratory of Neurological Disease, Ministry of Education, China
PLoS ONE 8:e55384. 2013....
- Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicityM Zhang
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China
Neuroscience 166:1083-90. 2010..Since NMDARs, Ca(2+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders...
- Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteinsGuillermo M Elias
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 52:307-20. 2006..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
- Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 proteinYuan Xiang Tao
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 23:6703-12. 2003..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
- Characterization of zebrafish PSD-95 gene family membersMartin P Meyer
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305, USA
J Neurobiol 63:91-105. 2005..These data are consistent with the idea that PSD-95 family members are involved in synapse assembly and function, and provide a platform for future functional studies in vivo in a highly tractable model organism...
- Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteinsDmitri Leonoudakis
Department of Molecular, Cellular, University of California, Santa Barbara, California 93106, USA
J Biol Chem 279:22331-46. 2004..We identified eight members of the MAGUK family of proteins (SAP97, PSD-95, Chapsyn-110, SAP102, CASK, Dlg2, Dlg3, and Pals2), two isoforms of Veli (Veli-1 and Veli-3), Mint1, and actin-binding LIM protein (abLIM) as Kir2...
- Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cellsT Claudepierre
INSERM EMI 99 18, Laboratoire de Physiopathologie Moléculaire et Cellulaire de la Rétine, CHRU, France
J Cell Sci 113:3409-17. 2000....
- [MAGUKs: beyond ionic channel anchoring]David Godreau
INSERM U 460, Batiment 13, CHU Xavier Bichat Claude Bernard, 46, rue Henri Huchard, 75877 Paris 18, France
Med Sci (Paris) 20:84-8. 2004..In the heart also, MAGUK proteins are abundantly expressed and they interact with various channels including Shaker Kv1.5 and connexins...
- Research progress on neurobiology of neuronal nitric oxide synthaseChun Xia Luo
Department of Pharmacology, School of Pharmacy, Laboratory of Cerebrovascular Disease, Nanjing Medical University, Nanjing 210029, China
Neurosci Bull 27:23-35. 2011..leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and ..
- Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retinaP Koulen
, D 60528 Frankfurt, Germany
J Neurosci 18:10136-49. 1998..Double-labeling experiments also were performed for PSD-95 and for the NR1 subunit of the NMDA receptor. They were found to be colocalized in synaptic hot spots in the IPL...
- Interactions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK)Ming Lei Guo
Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
Brain Res 1465:18-25. 2012..Our data provide evidence supporting PSD-93 as a new substrate of the synaptic species of ERK. ERK2 possesses the ability to interact with PSD-93 and phosphorylate PSD-93 at a specific site...
- A genome-wide association study identifies susceptibility loci for Wilms tumorClare Turnbull
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Nat Genet 44:681-4. 2012..32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22...
- Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapseMajid Nikpay
Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Hypertens Res 35:585-91. 2012..numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic function and ..
- Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retinaSalvatore L Stella
Department of Ophthalmology, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri, United States of America
PLoS ONE 7:e43463. 2012..These findings provide convincing evidence for Shank 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95/Shank 1 complexes at cone synapses in the outer retina...
- Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteinsS J DeMarco
Program in Molecular Neuroscience, Department of Biochemistry, Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 276:21594-600. 2001..The related MAGUKs SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bound to the COOH-terminal tail of PMCA4b, whereas only the first three bound ..
- Synaptic scaffold evolution generated components of vertebrate cognitive complexityJess Nithianantharajah
Genes to Cognition Programme, Centre for Clinical Brain Sciences and Centre for Neuroregeneration, The University of Edinburgh, Edinburgh, UK
Nat Neurosci 16:16-24. 2013..carrying mutations in each of the four Dlg paralogs showed that simple associative learning required Dlg4, whereas Dlg2 and Dlg3 diversified to have opposing functions in complex cognitive processes...
- The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteinsSally Roberts
School of Cancer Sciences, University of Birmingham, UK
FEBS J 279:3549-58. 2012..However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known...
- Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjectsVanja Duric
Department of Psychiatry, Yale University, New Haven, CT 06508, USA
Int J Neuropsychopharmacol 16:69-82. 2013..Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and ..
- Interaction of brain somatostatin receptors with the PDZ domains of PSD-95Marcus Christenn
Institut fur Zellbiochemie und klinische Neurobiologie, Martinistrasse 52, 20246 Hamburg, Germany
FEBS Lett 581:5173-7. 2007..As functional parameters of the receptor, such as coupling to potassium channels, are not affected by the interaction with PSD-95, the association may serve to localize the receptor to postsynaptic sites...
- PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitorsHong Cui
NoNO Inc, Toronto, Ontario, Canada M8X 1R5
J Neurosci 27:9901-15. 2007..Consequently, PSD-95 inhibition may constitute a highly specific strategy for treating excitotoxic disorders...
- Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturationSabine Lindquist
Department of Neurology, Hannover Medical School, Hannover, Germany
PLoS ONE 6:e23978. 2011..kinase activity is now reduced (-20-30%), pointing to the development of a compensatory mechanism that may involve PSD93. The distribution of the Csk-homologous kinase CHK is not altered...
- Effect of PSD-95/SAP90 and/or PSD-93/chapsyn-110 deficiency on the minimum alveolar anesthetic concentration of halothane in miceFeng Tao
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Anesthesiology 112:1444-51. 2010....
- Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retinaJun Zhang
Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
J Neurosci 29:4274-86. 2009....
- The extreme C-terminus of GluRdelta2 is essential for induction of long-term depression in cerebellar slicesKazuhisa Kohda
Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Eur J Neurosci 25:1357-62. 2007..Together, these results indicate that PDZ proteins that bind to the C-terminus of GluRdelta2 are not essential for localizing GluRdelta2 at synapses but are crucial for conveying signals necessary for the induction of LTD...
- Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensionsJonathan M Elkins
Structural Genomics Consortium, Oxford University, Botnar Research Centre, Oxford, OX3 7LD, United Kingdom
Protein Sci 16:683-94. 2007..using this approach and focus on four which provide information on selectivity (PICK1 and the third PDZ domain of DLG2), binding site flexibility (the third PDZ domain of MPDZ), and peptide-domain interactions (MPDZ 12th PDZ domain)...
- Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorderRobert E McCullumsmith
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, CIRC 576A 0021, 1530 3rd Avenue South, Birmingham, AL 35294, USA
Brain Res 1127:108-18. 2007..proteins critical for NMDA receptor assembly, trafficking, and activation; the most well-characterized being PSD93, PSD95, SAP102, and NF-L...
- Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairmentsLing Qiang Zhu
Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People s Republic of China
J Neurosci 27:12211-20. 2007..In postsynaptic level, the expression of PSD93 and NR2A/B proteins decreased significantly when GSK-3 was activated...
- PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and downQian Sun
Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
J Neurosci 31:6800-8. 2011....
- Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitroErik J MacLaren
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB101SA, UK
Mol Cell Neurosci 47:93-9. 2011..Using this system we focused on three postsynaptic proteins DISC1, TNIK and PSD-93/DLG2 each of which is encoded by a schizophrenia susceptibility gene...
- Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axonsIdo Horresh
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
J Neurosci 28:14213-22. 2008..This mechanism is clearly distinct from the one operating at the axon initial segment, which requires PSD-93 for Kv1 channel clustering...
- Structure of the first PDZ domain of human PSD-93Monica Fiorentini
Biostructural Research, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
Acta Crystallogr Sect F Struct Biol Cryst Commun 65:1254-7. 2009..However, the cleft is significantly narrower in PSD-95. This could be part of the basis of peptide selectivity between PSD-93 PDZ1 and PSD-95 PDZ1...
- ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axonsYasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 30:1038-48. 2010..2 and Caspr2 clustering is normal in ADAM22-null mice. Thus, ADAM22 is an axonal component of the Kv1 K(+) channel complex that recruits MAGUKs to juxtaparanodes...
- Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2Yasuhiro Ogawa
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 28:5731-9. 2008..In contrast, Caspr2, which mediates Kv1 channel clustering at the juxtaparanode, is not required for localization of Kv1 channels at the AIS. These results show PSD-93 mediates AIS accumulation of Kv1 channels independently of Caspr2...
- Post-synaptic density-93 mediates tyrosine-phosphorylation of the N-methyl-D-aspartate receptorsY Sato
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuroscience 153:700-8. 2008..Our findings indicate that PSD-93 appears to mediate tyrosine-phosphorylation of the NMDA receptors and synaptic localization of Fyn...
- Distribution of the scaffolding proteins PSD-95, PSD-93, and SAP97 in isolated PSDsJoseph A DeGiorgis
Laboratory of Neurobiology, National Institutes of Health, NINDS, Building 49, Room 3A60, 49 Convent Drive, Bethesda, MD 20892, USA
Brain Cell Biol 35:239-50. 2006..The distribution of SAP97 confirms that this protein is actually an integral component of the PSD, and suggests that it may have a role in inserting or stabilizing its main binding partner, Glu-R1, at the edge of the PSD...
- Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteinsSarah L Cousins
School of Pharmacy, University of London, London, UK
J Neurochem 104:903-13. 2008..This has implications for the stabilisation, turnover and compartmentalisation of NMDA receptor subtypes in neurones during development and in the mature brain...
- The role of SAP97 in synaptic glutamate receptor dynamicsMacKenzie A Howard
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 107:3805-10. 2010..However, due to functional redundancy, other PSD-MAGUKs can presumably compensate when SAP97 is conditionally deleted during development...
- SAP102 is a highly mobile MAGUK in spinesChan Ying Zheng
Laboratories of Neurochemistry and Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 30:4757-66. 2010..These differences and the compensatory properties of the MAGUKs point out an unrecognized versatility of the MAGUKs in their function in synaptic organization and plasticity...
- The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivoMadelaine M Rosenberg
Department of Neuroscience, Tufts University, Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
J Neurosci 30:11073-85. 2010..APC human gene mutations correlate with autism spectrum disorders, providing strong support for the importance of the association, demonstrated here, between APC, neuroligin and neurexin...
- Non-random inactivation of large common fragile site genes in different cancersS McAvoy
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Cytogenet Genome Res 118:260-9. 2007..cancers, we examined the expression of 13 of the 20 known large CFS genes: FHIT, WWOX, PARK2, GRID2, NBEA, DLG2, RORA isoforms 1 and 4, DAB1, CNTNAP2, DMD, IL1RAPL1, IMMP2L and LARGE in breast, ovarian, endometrial and brain ..
- Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26Ziad J Sahab
1 Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Department of Oncology, Washington, DC, 20007, USA
J Cancer 1:14-22. 2010....
- Expression pattern of membrane-associated guanylate kinases in interneurons of the visual cortexGulcan Akgul
State University of New York at Stony Brook, 11794 5230, USA
J Comp Neurol 518:4842-54. 2010....
- Distinct expression of synaptic NR2A and NR2B in the central nervous system and impaired morphine tolerance and physical dependence in mice deficient in postsynaptic density-93 proteinWen Jinn Liaw
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mol Pain 4:45. 2008..The selective effect of PSD-93 deletion on synaptic NMDAR expression in these two major pain-related regions might provide the better strategies for the prevention and treatment of opioid tolerance and physical dependence...
- Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brainFang Deng
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 26:7875-84. 2006..These experiments identify MAGI-2 as a strong candidate for linking TARP/AMPA receptor complexes to a wide range of other postsynaptic molecules and pathways and advance our knowledge of protein interactions at mammalian CNS synapses...
- Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21S A Smith
Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
Genomics 31:145-50. 1996..The DLG3 gene is located on chromosome 17, in the same segment, 17q12-q21, as the related gene, DLG2. The products of the DLG2 and DLG3 genes show 36% identity and 58% similarity to each other, and both show nearly ..
- Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranesM Russwurm
Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
J Biol Chem 276:44647-52. 2001....
- PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellumA W McGee
Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
J Neurosci 21:3085-91. 2001..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity...
- Enrichment of N-methyl-D-aspartate NR1 splice variants and synaptic proteins in rat postsynaptic densitiesR A Al-Hallaq
Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington DC 20007, USA
J Neurochem 77:110-9. 2001..Thus, although postsynaptic densities are highly enriched in synaptic proteins, there appears to be no selective incorporation of specific NR1 splice variants or NR2 subunits into this structure...
- Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95S Inagaki
Group of Neurobiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Yamadaoka 1 7, Suita Shi, Osaka, 565 0871, Japan
J Biol Chem 276:9174-81. 2001..In neocortical culture, S4C is colocalized with PSD-95 in neurons, with a dot-like pattern along the neurites. Sema4C thus may function in the cortical neurons as a bi-directional transmembrane ligand through interacting with PSD-95...
- The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthaseK Haraguchi
Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Japan
Genes Cells 5:905-911. 2000..PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP)...
- Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domainsB L Firestein
Department of Physiology, University of California at San Francisco, 94143 0444, USA
Neuroreport 11:3479-84. 2000..These results suggest that MAGUKs contain diverse signals within their N-termini for postsynaptic targeting...
- Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95M Passafaro
Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
Nat Neurosci 2:1063-9. 1999..However, the number of synapses and the synaptic clustering of NMDA receptors were unaffected, suggesting that PSD-95-family proteins are not essential for the maintenance of synapses and the synaptic localization of NMDA receptors...
- Localization of synapse-associated proteins during postnatal development of the rat retinaP Koulen
Max Planck Institut für Hirnforschung, Abteilung fur Neuroanatomie, Frankfurt am Main, Germany
Eur J Neurosci 11:2007-18. 1999..Possible functions of the early expression of SAPs well before differentiation and maturation of glutamatergic ribbon synapses are discussed...
- Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brainM Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
Neurosci Res 33:111-8. 1999....
- Interaction of neuronal nitric-oxide synthase with alpha1-syntrophin in rat brainA Hashida-Okumura
Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
J Biol Chem 274:11736-41. 1999..These results indicate that nNOS in brain interacts with alpha1-syntrophin in specific neurons of the SCN and paraventricular nucleus and that this interaction might play a physiological role in functions of these neurons...
- Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifsS E Craven
Department of Physiology and Program in Neuroscience, University of California, San Francisco 94143 0444, USA
Neuron 22:497-509. 1999..The requirements for PDZ domains and a C-terminal domain of PSD-95 indicate that protein-protein interactions cooperate with lipid interactions in synaptic targeting...
- Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesE Kim
Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
Nature 378:85-8. 1995..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
- Localization of Dlg at the mammalian neuromuscular junctionJ A Rafael
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neuroreport 9:2121-5. 1998..Dlg may therefore be important for establishing or maintaining the organization of protein complexes at the mammalian NMJ...
- Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsJ E Brenman
Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
Cell 84:757-67. 1996..Interaction of PDZ-containing domains therefore mediates synaptic association of nNOS and may play a more general role in formation of macromolecular signaling complexes...
- Binding of neuroligins to PSD-95M Irie
Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2 2 10, Murotani, Nishi ku, Kobe, 651 22, Japan
Science 277:1511-5. 1997..Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins...
- Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting proteinJ E Brenman
Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
J Neurosci 16:7407-15. 1996....
- Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapsesAtsushi Inanobe
Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
Am J Physiol Cell Physiol 282:C1396-403. 2002..Therefore, the Kir channel may be involved in formation of the resting membrane potential of the spines and, thus, would affect the response of N-methyl-D-aspartic acid receptor channels at the excitatory postsynaptic membrane...
- An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1Mark L Leyland
Department of Biochemistry, University of Leicester, PO Box 138, LE1 9HN, UK
J Biol Chem 279:43427-36. 2004..1 clustering and suppression of channel internalization. We conclude that PSD-93delta is potentially an important regulator of the spatial and temporal distribution of Kir2 channels within neuronal membranes of the central nervous system...
- Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophreniaHelena T Mueller
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Brain Res Mol Brain Res 121:60-9. 2004..These data support the hypothesis that schizophrenia may involve alterations in dopamine-glutamate interactions...
- Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defectsRineke Steenbergen
Canadian Institutes for Health Research Group on the Molecular and Cell Biology of Lipids and Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 280:40032-40. 2005..Moreover, elimination of PE production in mitochondria causes fragmented, misshapen mitochondria, an abnormality that likely contributes to the embryonic lethality...
- Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95Mio Nonaka
Department of Biophysics, Kyoto University Graduate School of Science, Kyoto 606 8502, Japan
J Neurosci 26:763-74. 2006....
- Control of synaptic connection by glutamate receptor delta2 in the adult cerebellumTomonori Takeuchi
Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and Solution Oriented Research for Science and Technology, Japan Science and Technology Agency, Tokyo 113 0033, Japan
J Neurosci 25:2146-56. 2005..We thus identified postsynaptic GluRdelta2 as a key regulator of the presynaptic active zone and PSD organization at parallel fiber-PC synapses in the adult brain...
- Identification of PSD-93 as a substrate for the Src family tyrosine kinase FynShigeyuki Nada
Department of Oncogene Research, Research Institute for Microbial Disease, Osaka University, Suita, Osaka 565 0871, Japan
J Biol Chem 278:47610-21. 2003..These results suggest that PSD-93 serves as a membrane-anchored substrate of Fyn and plays a role in the regulation of Fyn-mediated modification of NMDA receptor function...
- Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulbMarco Sassoè-Pognetto
Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, I 10126 Torino, Italy
J Comp Neurol 463:237-48. 2003..The latter molecules appear to be expressed in an all-or-none fashion and may form a standard lattice common to different types of glutamatergic synapse...
- Protein 4.1-mediated membrane targeting of human discs large in epithelial cellsToshihiko Hanada
Department of Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
J Biol Chem 278:34445-50. 2003..introduced a double mutation (I38A/I40A) into the N-terminal domain of hDlg, which disrupted its interaction with DLG2, a key event in the membrane targeting of hDlg...
- Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophreniaSarah M Clinton
Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
Am J Psychiatry 160:1100-9. 2003..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
- Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expressionGabriela Lavezzari
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 36, Room 5B20, 9000 Rockville Pike, Bethesda, MD 20892, USA
Neuropharmacology 45:729-37. 2003....
- Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardiumDavid Godreau
INSERM Unité 460, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
Cardiovasc Res 56:433-42. 2002..Here, we studied the expression and role of these anchoring proteins in human right atrial myocardium by means of various molecular, biochemical and physiological methods...
- Differential expression of a new isoform of DLG2 in renal oncocytomaDmitry Zubakov
Laboratory of Molecular Oncology, Medical Faculty, Ruprecht Karls University, Heidelberg, Germany
BMC Cancer 6:106. 2006..Therefore, identification of molecular markers would be of great value for molecular diagnostics of this tumour type...
- Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophreniaKazuhiko Toyooka
Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
J Neurochem 83:797-806. 2002..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...
- Olivocerebellar Circuitry in AutismGene J Blatt; Fiscal Year: 2010..Co-localization of GluRo2 with PSD93 will determine the percentage of postsynaptic density and co-localization of EAAT4 with synaptophysin will ..
- REGULATION OF NEURONAL SYNAPTIC COMPONENTSMichele Jacob; Fiscal Year: 2009..Further, the studies will determine whether the organizational mechanisms are shared between peripheral neuron and central sensory nicotinic synapses. ..
- Interaction of Anesthetics with Neuronal PDZ DomainsRoger Johns; Fiscal Year: 2009....
- Role of Spinal Cord PSD-93/Chapsyn-110 in Chronic PainRoger Johns; Fiscal Year: 2007..These studies will provide a novel insight to the mechanisms of chronic pain and a new and potential biochemical target for the prevention and therapy of chronic pain. [unreadable] [unreadable]..
- SYNAPTIC REGULATION OF NITRIC OXIDEDavid Bredt; Fiscal Year: 2005..On the other hand, an extended "P-finger" of the NNOS PDZ domain binds to PSD-95 and PSD-93, postsynaptic density proteins that mediate synaptic clustering of NMDA receptors. ..
- Modulation of parasympathetic neurons by PACAP peptidesRODNEY PARSONS; Fiscal Year: 2005....
- CENTER FOR NEUROSCIENCE EXCELLENCERodney L Parsons; Fiscal Year: 2010....
- Chemically specified synaptogenesis in the visual cortexChiye Aoki; Fiscal Year: 2004..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
- NR3 Expression in Human BrainHelena Mueller; Fiscal Year: 2003..abstract_text> ..
- SYNAPTOGENESIS IN THE CEREBRAL CORTEXChiye Aoki; Fiscal Year: 2003..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..