Genomes and Genes
Gene Symbol: DLG2
Description: discs large MAGUK scaffold protein 2
Alias: PPP1R58, PSD-93, PSD93, chapsyn-110, disks large homolog 2, channel-associated protein of synapse-110, channel-associated protein of synapses, 110kDa, discs large 2, discs, large homolog 2, chapsyn-110, postsynaptic density protein PSD-93, protein phosphatase 1, regulatory subunit 58
Publications152 found, 100 shown here
- Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASKKai Schuh
Department of Medicine, University of Wuerzburg, D 97080 Wuerzburg, Germany
J Biol Chem 278:9778-83. 2003..In particular, SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bind to the C-terminal tails of PMCA "b" splice variants...
- Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motifChunlin Cai
Department of Biosciences, Division of Biochemistry, University of Helsinki, Helsinki FIN 00014, Finland
J Biol Chem 277:31484-90. 2002....
- SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunitA S Leonard
Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
J Biol Chem 273:19518-24. 1998..Our findings suggest that SAP97 may be involved in localizing AMPA receptors at postsynaptic sites through its interaction with the GluR1 subunit...
- Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95Heike Hering
Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue E18 215, Cambridge, MA 02139, USA
FEBS Lett 521:185-9. 2002....
- Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteinsE Kim
Howard Hughes Medical Institute, Department of Neurobiology, Massachusetts General Hospital, Boston 02114, USA
Neuron 17:103-13. 1996..Thus, chapsyn-110 and PSD-95 may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signalling proteins...
- Molecular abnormalities of the glutamate synapse in the thalamus in schizophreniaJames H Meador-Woodruff
Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Ann N Y Acad Sci 1003:75-93. 2003..for a given glutamate receptor subtype, the most well characterized being the NMDA receptor binding proteins PSD93, PSD95, NF-L, and SAP102...
- A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-AS Mazoyer
CRC Human Cancer Genetics Research Group, Addenbrooke s Hospital, Cambridge, United Kingdom
Genomics 28:25-31. 1995..and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors...
- Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophreniaL V Kristiansen
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
Mol Psychiatry 11:737-47, 705. 2006..Our findings suggest abnormal regional processing of the NMDA receptor and its associated PSD molecules, possibly involving transcription, translation, trafficking and protein stability in cortical areas in schizophrenia...
- Tumor suppressor CADM1 is involved in epithelial cell structureMika Sakurai-Yageta
Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
Biochem Biophys Res Commun 390:977-82. 2009..Here, we demonstrate that MPP1/p55 and MPP2/DLG2, as well as MPP3, interact with both CADM1 and 4.1B, forming a tripartite complex...
- Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depressionLars V Kristiansen
Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Schizophr Res 78:87-93. 2005....
- Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anestheticsMing Fang
Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Biol Chem 278:36669-75. 2003..These findings reveal the PDZ domain as a new molecular target for inhalational anesthetics...
- Interactions between Src family protein tyrosine kinases and PSD-95Lorraine V Kalia
Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario M5G 1X8, Canada
Neuropharmacology 45:720-8. 2003..Together our results suggest that PSD-95 may be important for localizing and/or regulating multiple Src protein tyrosine kinases at the NMDA receptor multiprotein complex...
- Interaction of transmembrane AMPA receptor regulatory proteins with multiple membrane associated guanylate kinasesSrikanth Dakoji
Department of Physiology, UCSF School of Medicine, University of California at San Francisco, Genentech Hall 600 16th Street, N272 F, San Francisco, CA 94143 2140, USA
Neuropharmacology 45:849-56. 2003..This work identifies biochemical promiscuity for interaction of the TARP C-termini with PDZ domains in vitro, but also shows that only specific synaptic PDZ proteins associate with TARPs in brain...
- Neuronal nicotinic synapse assembly requires the adenomatous polyposis coli tumor suppressor proteinMurali Krishna Temburni
Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Neurosci 24:6776-84. 2004..The results show that APC plays a key role in organizing excitatory cholinergic postsynaptic specializations in CG neurons. We identify APC as the first nonreceptor protein to function in localizing nAChRs to neuronal synapses in vivo...
- A novel mutation in the DLG3 gene encoding the synapse-associated protein 102 (SAP102) causes non-syndromic mental retardationGinevra Zanni
Institut Cochin, Universite Paris Descartes, INSERM, CNRS UMR 8104, CHU Cochin, Paris, France
Neurogenetics 11:251-5. 2010..membrane-associated guanylate kinase protein subfamily comprising SAP97, postsynaptic density (PSD)95, and PSD93, which interacts with methyl-D-aspartate receptor and associated protein complexes at the postsynaptic density of ..
- Evaluation of DLG2 as a positional candidate for disposition index in African-Americans from the IRAS Family StudyNicholette D Palmer
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Diabetes Res Clin Pract 87:69-76. 2010Evaluate discs large homolog 2 (DLG2) as a positional candidate gene for disposition index (DI) in the Insulin Resistance Atherosclerosis Family Study (IRAS-FS) African-American sample.
- In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93Ilse Delint-Ramirez
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
J Neurosci 30:8162-70. 2010..These data show critical roles for scaffold proteins and their interactions with NMDA receptor subunits in organizing the differential expression in rafts and postsynaptic densities of synaptic signaling complexes...
- Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin miceHitoshi Nagura
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
Mol Brain 5:43. 2012....
- Downregulation of Src-kinase and glutamate-receptor phosphorylation after traumatic brain injuryYujung Park
Neurochemistry Laboratory of Brain Injury, Department of Anesthesiology, and Shock Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 33:1642-9. 2013..fractions obtained from the ipsilateral neocortical injury region, whereas the levels of NR2A, NR1, and PSD93 were not significantly altered at 4 and 24 hours after TBI...
- Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genesAbdul Noor
Molecular Neuropsychiatry and Development Lab, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Am J Med Genet B Neuropsychiatr Genet 165:303-13. 2014..analyses, we identified CNVs implicating several candidate genes that encode synaptic proteins, such as DLG1, DLG2, DPP6, NRXN1, NRXN2, NRXN3, SHANK2, and EPHA5, as well as the neuronal splicing regulator RBFOX1 (A2BP1), and ..
- Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcomaXiang Chen
Department of Computational Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Cell Rep 7:104-12. 2014..Beyond TP53, the RB1, ATRX, and DLG2 genes showed recurrent somatic alterations in 29%-53% of the tumors...
- Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodentsZoltan Sarnyai
Discipline of Physiology and Pharmacology, James Cook University, Townsville, QLD, Australia Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia Comparative Genome Centre, James Cook University, Townsville, QLD, Australia Centre for Biodiscovery and Molecular Development of Therapeutics, James Cook University, Townsville, QLD, Australia Electronic address
Behav Brain Res 276:130-42. 2015....
- CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's diseaseXia Jiang
Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, P R China Department of Pathology, Hubei University of Chinese Medicine, Wuhan, Hubei Province, P R China
Neurobiol Aging 36:867-76. 2015..Spatial training also increased the levels of postsynaptic GluA1, GluN2A, GluN2B, and PSD93 with selective activation of calcium/calmodulin-dependent protein kinase II (CaMKII), although inhibition of ..
- Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK LossJonathan M Levy
Neuroscience Graduate Program, University of California San Francisco, San Francisco, CA 94158, USA Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA
Neuron 87:534-48. 2015..Consolidation requires signaling through L-type calcium channels, CaM kinase kinase, and the GluA2 AMPA receptor subunit, akin to a homeostatic process. ..
- Identification of Genes Associated with Papillary Thyroid Carcinoma (PTC) for Diagnosis by Integrated AnalysisW B Li
Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing, Medical University, Chongqing, China
Horm Metab Res 48:226-31. 2016..In the PPI network, MLLT1, DLG2, and EFEMP1 were the hub proteins, in which DLG2 and EFEMP1 were involved in tumor progression...
- An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of SchizophreniaPeng Yan
College of Forensic, Key Laboratory of Ministry of Public Health for Forensic Science, Xi an Jiaotong University, Xi an, Shaanxi, People s Republic of China
J Mol Neurosci 59:366-75. 2016..To identify markers of disks, large homolog 2 (DLG2), FAT atypical cadherin 3 (FAT3), kinectin1 (KTN1), deleted in colorectal carcinoma (DCC), and glycogen synthase ..
- Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum DisordersJingrui Xing
Department of Psychiatry, Nagoya University Graduate School of Medicine, 466 8550 Nagoya, Japan
Sci Rep 6:27491. 2016..We sequenced the protein-encoding regions of DLG1, DLG2, DLG4, DLGAP1, DLGAP2, and SynGAP in 562 cases (370 SZ and 192 ASD patients) on the Ion PGM platform...
- RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatumNeelam Shahani
Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA
Sci Signal 9:ra111. 2016..disorder), LRRC7 (leucine-rich repeat-containing 7; a protein associated with bipolar disorder and ADHD), and DLG2 (discs large homolog 2; a protein associated with chronic pain)...
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapsesR A Garcia
Unit on Molecular Neurobiology, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 97:3596-601. 2000..As discussed, the interactions found between receptor tyrosine kinases and MAGUKs at neuronal synapses may have important implications for activity-dependent plasticity...
- Improved immunohistochemical detection of postsynaptically located PSD-95/SAP90 protein family by protease section pretreatment: a study in the adult mouse brainM Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
J Comp Neurol 426:572-86. 2000..Consequently, the present immunohistochemical results have provided light microscopic evidence supporting the prevailing notion that the PSD-95/SAP90 protein family interacts with NMDA receptor subunits and potassium channel subunits...
- Effect of knock down of spinal cord PSD-93/chapsin-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injuryBosheng Zhang
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, MD 21205, USA
Pain 106:187-96. 2003..This suggests that spinal cord PSD-93/chapsin-110 might be involved in the central mechanism of chronic pain. Our work might provide a new target for the therapy of chronic pain...
- PSD93 regulates synaptic stability at neuronal cholinergic synapsesMichael J Parker
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:378-88. 2004..We find that novel splicing forms of PSD93 (postsynaptic density 93) are expressed in SCG...
- Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPasesJeonghoon Choi
National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 25:869-79. 2005..These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis...
- Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosetsM J Hurley
Neurodegenerative Diseases Research Group, Pharmaceutical Sciences Division, School of Health and Life Sciences, King s College, London, SE1 1UL, UK
Eur J Neurosci 21:3240-50. 2005..These results suggest that l-DOPA treatment of MPTP-lesioned marmosets can affect glutamatergic systems and indicate that altered NMDA receptor function may relate to dyskinesia...
- Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarraysMichael A Stiffler
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
J Am Chem Soc 128:5913-22. 2006....
- Promiscuous interactions between AMPA-Rs and MAGUKsStephen M Fitzjohn
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, United Kingdom
Neuron 52:222-4. 2006..In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons...
- Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signalingJesús F Torres-Peraza
Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain
Neurobiol Dis 29:409-21. 2008..The specific regulation of MAGUKs and alpha CaMKII in striatal neurons may reflect a protective mechanism against expression of mutant huntingtin exon-1...
- Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticityHolly J Carlisle
Department of Physiology, David Geffen School of Medicine at UCLA, 53 231 Center for the Health Sciences, Box 951751, Los Angeles, CA 90095 1751, USA
J Physiol 586:5885-900. 2008....
- A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variationKarol Estrada
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Hum Mol Genet 18:3516-24. 2009..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
- Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrationsAyse Demirkan
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
PLoS Genet 8:e1002490. 2012..Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ..
- Capsaicin ameliorates stress-induced Alzheimer's disease-like pathological and cognitive impairments in ratsXia Jiang
Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
J Alzheimers Dis 35:91-105. 2013..dendritic regression and enhanced several memory-associated proteins decreased by CWS, such as synapsin I and PSD93; CAP also prevented CWS-induced tau hyperphosphorylation by abolishing inhibition of protein phosphatase 2A...
- Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathwayYasunobu Murata
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Neurosci 33:5040-52. 2013..Both SAP102 and PAKs are associated with X-linked mental retardation in humans; thus, synapse formation mediated by EphB/SAP102/PAK signaling in the early postnatal brain may be crucial for cognitive development...
- Clinical significance of de novo and inherited copy-number variationAnneke T Vulto-van Silfhout
Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences and Institute for Genetic and Metabolic Disorders, Radboud University Medical Centre, Nijmegen, The Netherlands
Hum Mutat 34:1679-87. 2013..001), pointing to a combinatorial effect of the additional CNVs. In addition, we identified 20 de novo single-gene CNVs that directly indicate novel genes for ID/MCA, including ZFHX4, ANKH, DLG2, MPP7, CEP89, TRIO, ASTN2, and PIK3C3.
- PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemiaMeijuan Zhang
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, PR China Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, PR China Jiangsu Key Laboratory for Molecular Medicine, Nanjing, PR China Diagnosis and Therapy Center of Stroke in Jiangsu Province, PR China
Neurobiol Dis 68:104-11. 2014..These findings may provide a novel avenue for the treatment of ischemic stroke. ..
- Systematic family-wide analysis of sodium bicarbonate cotransporter NBCn1/SLC4A7 interactions with PDZ scaffold proteinsHye Jeong Lee
Department of Pediatrics, Division of Hematology and Oncology, Vanderbilt University, Nashville, Tennessee, USA
Physiol Rep 2:. 2014..Thus, syntrophin γ2 regulates NBCn1 activity. In conclusion, this study demonstrates that NBCn1 binds to many PDZ proteins, which in turn may allow the transporter to associate with other physiologically important proteins...
- Genome wide association scan for chronic periodontitis implicates novel locusPing Feng
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
BMC Oral Health 14:84. 2014....
- Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in miceQuan Ma
Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, China College of Life Sciences, Shenzhen University, Shenzhen, China
J Alzheimers Dis 43:1413-27. 2015..Taken together, we propose that chronic copper exposure might cause spatial memory impairment, selective loss of synaptic proteins, and neuronal apoptosis through the mechanisms involving activation of PKR/eIF2α signaling pathway. ..
- Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophreniaA Ingason
Department of Psychiatry, University of Halle Wittenberg, Halle, Germany
Transl Psychiatry 5:e656. 2015..association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4...
- Synaptically Localized Mitogen-Activated Protein Kinases: Local Substrates and RegulationLi Min Mao
Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO, 64108, USA
Mol Neurobiol 53:6309-6315. 2016..This review summarizes the recent progress in cell biology of synaptic MAPKs and analyzes roles of this specific pool of MAPKs in regulating local substrates and synaptic plasticity...
- Betaine reverses the memory impairments in a chronic cerebral hypoperfusion rat modelChunjie Nie
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China Electronic address
Neurosci Lett 615:9-14. 2016..Betaine also restored the expression of PSD93, PSD95 and MAP2 to preserve the synaptic functions...
- Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1AYosuke Takei
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan, Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
J Neurosci 35:15539-54. 2015..These data suggest that tethering of NR2A/2B with the cytoskeleton through MAP1A is fundamental for synaptic function...
- Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injuryRong Rong
Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, 210029 Jiangsu, China Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210029 Jiangsu, China Jiangsu Key Laboratory for Molecular Medicine, Nanjing, China
Neurotoxicology 53:1-11. 2016..Identification of these proteins provides valuable clues to elucidate the mechanisms underlying the actions of PSD-93 in ischemia-reperfusion induced neurotoxicity. ..
- The Effect of PSD-93 Deficiency on the Expression of Early Inflammatory Cytokines Induced by Ischemic Brain InjuryQingxiu Zhang
Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China
Cell Biochem Biophys 73:695-700. 2015..PSD-93 knockout may play a neuroprotective role by mediating the early release of inflammatory cytokines induced by cerebral ischemia. ..
- L1-associated genomic regions are deleted in somatic cells of the healthy human brainJennifer A Erwin
The Salk Institute for Biological Studies, La Jolla, California, USA
Nat Neurosci 19:1583-1591. 2016..We demonstrate that SLAVs are present in crucial neural genes, such as DLG2 (also called PSD93), and affect 44-63% of cells of the cells in the healthy brain.
- A Population-Based Study of Four Genes Associated with Heroin Addiction in Han ChineseYunxiao Li
College of Forensic Science, Xi an Jiaotong University, Key Laboratory of Ministry of Public Health for Forensic Science, Xi an, PR China
PLoS ONE 11:e0163668. 2016Recent studies have shown that variants in FAT atypical cadherin 3 (FAT3), kinectin 1 (KTN1), discs large homolog2 (DLG2) and deleted in colorectal cancer (DCC) genes influence the structure of the human mesolimbic reward system...
- Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like BehaviorsSeungmin Ha
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
J Neurosci 36:12129-12143. 2016..These results implicate Shank2 in the regulation of cerebellar excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors...
- Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cellsFrancesca Stillitano
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, United States
elife 6:. 2017..Transcriptomic profiling identified dysregulation of genes (DLG2, KCNE4, PTRF, HTR2C, CAMKV) involved in downstream regulation of cardiac repolarization machinery as ..
- Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapsesK W Roche
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 19:3926-34. 1999....
- Electron microscopic immunocytochemical detection of PSD-95, PSD-93, SAP-102, and SAP-97 at postsynaptic, presynaptic, and nonsynaptic sites of adult and neonatal rat visual cortexC Aoki
Center for Neural Science, New York University, New York, New York 10003, USA
Synapse 40:239-57. 2001..These results suggest that MAGUKs have dual roles: to maintain receptors at synapses and to regulate shuttling of receptors between nonsynaptic and synaptic sites...
- Phosphoproteomic analysis of synaptosomes from human cerebral cortexJoseph A DeGiorgis
Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Proteome Res 4:306-15. 2005..The study shows that new phosphoproteomic strategies can be used to analyze subcellular fractions from small amounts of tissue for the identification of phosphorylated residues for research and potentially for diagnostic purposes...
- Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retinaP Koulen
, D 60528 Frankfurt, Germany
J Neurosci 18:10136-49. 1998..Double-labeling experiments also were performed for PSD-95 and for the NR1 subunit of the NMDA receptor. They were found to be colocalized in synaptic hot spots in the IPL...
- Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Müller glial cellsT Claudepierre
INSERM EMI 99 18, Laboratoire de Physiopathologie Moléculaire et Cellulaire de la Rétine, CHRU, France
J Cell Sci 113:3409-17. 2000....
- Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 proteinYuan Xiang Tao
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Neurosci 23:6703-12. 2003..PSD-93 appears to be important for NMDAR synaptic targeting and function and to be a potential biochemical target for the treatment of persistent pain...
- [MAGUKs: beyond ionic channel anchoring]David Godreau
INSERM U 460, Batiment 13, CHU Xavier Bichat Claude Bernard, 46, rue Henri Huchard, 75877 Paris 18, France
Med Sci (Paris) 20:84-8. 2004..In the heart also, MAGUK proteins are abundantly expressed and they interact with various channels including Shaker Kv1.5 and connexins...
- Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteinsDmitri Leonoudakis
Department of Molecular, Cellular, University of California, Santa Barbara, California 93106, USA
J Biol Chem 279:22331-46. 2004..We identified eight members of the MAGUK family of proteins (SAP97, PSD-95, Chapsyn-110, SAP102, CASK, Dlg2, Dlg3, and Pals2), two isoforms of Veli (Veli-1 and Veli-3), Mint1, and actin-binding LIM protein (abLIM) as Kir2...
- Characterization of zebrafish PSD-95 gene family membersMartin P Meyer
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University, California 94305, USA
J Neurobiol 63:91-105. 2005..These data are consistent with the idea that PSD-95 family members are involved in synapse assembly and function, and provide a platform for future functional studies in vivo in a highly tractable model organism...
- Synapse-specific and developmentally regulated targeting of AMPA receptors by a family of MAGUK scaffolding proteinsGuillermo M Elias
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
Neuron 52:307-20. 2006..These studies establish a PSD-MAGUK-specific regulation of AMPA-R synaptic expression that establishes and maintains glutamatergic synaptic transmission in the mammalian central nervous system...
- NMDA di-heteromeric receptor populations and associated proteins in rat hippocampusRana A Al-Hallaq
Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurosci 27:8334-43. 2007..In summary, in rat hippocampus, NR2A and NR2B exist primarily in di-heteromeric complexes that interact similarly with PSD-95-related proteins but are associated with different protein complexes...
- Postsynaptic density-93 deficiency protects cultured cortical neurons from N-methyl-D-aspartate receptor-triggered neurotoxicityM Zhang
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, PR China
Neuroscience 166:1083-90. 2010..Since NMDARs, Ca(2+), and NO play a critical role during the development of brain trauma, seizures, and ischemia, the present work suggests that PSD-93 might contribute to molecular mechanisms of neuronal damage in these brain disorders...
- Research progress on neurobiology of neuronal nitric oxide synthaseChun Xia Luo
Department of Pharmacology, School of Pharmacy, Laboratory of Cerebrovascular Disease, Nanjing Medical University, Nanjing 210029, China
Neurosci Bull 27:23-35. 2011..leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and ..
- High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signalingYang Yang
Key Laboratory of Neurological Disease, Ministry of Education, China
PLoS ONE 8:e55384. 2013....
- Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopyMonica Fiorentini
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Acta Crystallogr D Biol Crystallogr 69:587-94. 2013PSD-93 (chapsyn-110, DLG2) is a member of the family of membrane-associated guanylate kinase (MAGUK) proteins. The MAGUK proteins are involved in receptor localization and signalling pathways...
- Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmissionJuliane M Krüger
European Neuroscience Institute, 37077 Gottingen, Germany, Göttingen Graduate School for Neurosciences and Molecular Biosciences, 37077 Gottingen, Germany, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02319, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany, International Max Planck Research School for Neuroscience, 37077 Gottingen, Germany, Bioanalytics, Department of Clinical Chemistry, 37075 Gottingen, Germany, and Department of Neuroscience, University of Pittsburgh, Pennsylvania 15260
J Neurosci 33:15504-17. 2013..Collectively, these results demonstrate that alternative combinations of N-terminal PSD-93 isoforms and DLG-MAGUK paralogs can fine-tune signaling scaffolds to adjust synaptic needs to regulate synaptic transmission. ..
- Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteinsS J DeMarco
Program in Molecular Neuroscience, Department of Biochemistry, Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 276:21594-600. 2001..The related MAGUKs SAP90/PSD95, PSD93/chapsyn-110, SAP97, and SAP102 all bound to the COOH-terminal tail of PMCA4b, whereas only the first three bound ..
- Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapseMajid Nikpay
Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Hypertens Res 35:585-91. 2012..numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic function and ..
- Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjectsVanja Duric
Department of Psychiatry, Yale University, New Haven, CT 06508, USA
Int J Neuropsychopharmacol 16:69-82. 2013..Our findings demonstrate significant dysregulation of synaptic function/structure related genes SNAP25, DLG2 (SAP93), and MAP1A, and 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid receptor subunit genes GLUR1 and ..
- A genome-wide association study identifies susceptibility loci for Wilms tumorClare Turnbull
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
Nat Genet 44:681-4. 2012..32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22...
- Interactions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK)Ming Lei Guo
Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
Brain Res 1465:18-25. 2012..Our data provide evidence supporting PSD-93 as a new substrate of the synaptic species of ERK. ERK2 possesses the ability to interact with PSD-93 and phosphorylate PSD-93 at a specific site...
- The PDZ protein discs-large (DLG): the 'Jekyll and Hyde' of the epithelial polarity proteinsSally Roberts
School of Cancer Sciences, University of Birmingham, UK
FEBS J 279:3549-58. 2012..However, whether mammalian homologues of DLG (DLG1, DLG2, DLG3 and DLG4) also possess tumour suppressor functions is not known...
- Association of shank 1A scaffolding protein with cone photoreceptor terminals in the mammalian retinaSalvatore L Stella
Department of Ophthalmology, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri, United States of America
PLoS ONE 7:e43463. 2012..These findings provide convincing evidence for Shank 1A expression in both the inner and outer plexiform layers, and indicate a potential role for PSD-95/Shank 1 complexes at cone synapses in the outer retina...
- Synaptic scaffold evolution generated components of vertebrate cognitive complexityJess Nithianantharajah
Genes to Cognition Programme, Centre for Clinical Brain Sciences and Centre for Neuroregeneration, The University of Edinburgh, Edinburgh, UK
Nat Neurosci 16:16-24. 2013..carrying mutations in each of the four Dlg paralogs showed that simple associative learning required Dlg4, whereas Dlg2 and Dlg3 diversified to have opposing functions in complex cognitive processes...
- Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinasesE Kim
Howard Hughes Medical Institute, Massachusetts General Hospital, Department of Neurobiology, Harvard Medical School, Boston 02114, USA
Nature 378:85-8. 1995..3) and syntrophin), suggest that PDZ-domain-containing polypeptides may be widely involved in the organization of proteins at sites of membrane specialization...
- Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domainsJ E Brenman
Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
Cell 84:757-67. 1996..Interaction of PDZ-containing domains therefore mediates synaptic association of nNOS and may play a more general role in formation of macromolecular signaling complexes...
- Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21S A Smith
Huntsman Cancer Institute, University of Utah, Salt Lake City, USA
Genomics 31:145-50. 1996..The DLG3 gene is located on chromosome 17, in the same segment, 17q12-q21, as the related gene, DLG2. The products of the DLG2 and DLG3 genes show 36% identity and 58% similarity to each other, and both show nearly ..
- Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting proteinJ E Brenman
Department of Physiology, University of California at San Francisco School of Medicine, 94143 0444, USA
J Neurosci 16:7407-15. 1996....
- Binding of neuroligins to PSD-95M Irie
Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, 2 2 10, Murotani, Nishi ku, Kobe, 651 22, Japan
Science 277:1511-5. 1997..Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins...
- Localization of Dlg at the mammalian neuromuscular junctionJ A Rafael
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Neuroreport 9:2121-5. 1998..Dlg may therefore be important for establishing or maintaining the organization of protein complexes at the mammalian NMJ...
- Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifsS E Craven
Department of Physiology and Program in Neuroscience, University of California, San Francisco 94143 0444, USA
Neuron 22:497-509. 1999..The requirements for PDZ domains and a C-terminal domain of PSD-95 indicate that protein-protein interactions cooperate with lipid interactions in synaptic targeting...
- Interaction of neuronal nitric-oxide synthase with alpha1-syntrophin in rat brainA Hashida-Okumura
Division of Protein Metabolism, Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita, Osaka 565 0871, Japan
J Biol Chem 274:11736-41. 1999..These results indicate that nNOS in brain interacts with alpha1-syntrophin in specific neurons of the SCN and paraventricular nucleus and that this interaction might play a physiological role in functions of these neurons...
- Distinct spatiotemporal expression of mRNAs for the PSD-95/SAP90 protein family in the mouse brainM Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
Neurosci Res 33:111-8. 1999....
- Localization of synapse-associated proteins during postnatal development of the rat retinaP Koulen
Max Planck Institut für Hirnforschung, Abteilung fur Neuroanatomie, Frankfurt am Main, Germany
Eur J Neurosci 11:2007-18. 1999..Possible functions of the early expression of SAPs well before differentiation and maturation of glutamatergic ribbon synapses are discussed...
- Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95M Passafaro
Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, HHMI Wellman 423, 50 Blossom Street, Boston, Massachusetts 02114, USA
Nat Neurosci 2:1063-9. 1999..However, the number of synapses and the synaptic clustering of NMDA receptors were unaffected, suggesting that PSD-95-family proteins are not essential for the maintenance of synapses and the synaptic localization of NMDA receptors...
- Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domainsB L Firestein
Department of Physiology, University of California at San Francisco, 94143 0444, USA
Neuroreport 11:3479-84. 2000..These results suggest that MAGUKs contain diverse signals within their N-termini for postsynaptic targeting...
- The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthaseK Haraguchi
Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Japan
Genes Cells 5:905-911. 2000..PSD-95 also interacts with the hDLG-associated protein DAP, which is also called Synapse-associated protein 90-associated protein (SAPAP), and Guanylate kinase-associated protein (GKAP)...
- Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95S Inagaki
Group of Neurobiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Yamadaoka 1 7, Suita Shi, Osaka, 565 0871, Japan
J Biol Chem 276:9174-81. 2001..In neocortical culture, S4C is colocalized with PSD-95 in neurons, with a dot-like pattern along the neurites. Sema4C thus may function in the cortical neurons as a bi-directional transmembrane ligand through interacting with PSD-95...
- Enrichment of N-methyl-D-aspartate NR1 splice variants and synaptic proteins in rat postsynaptic densitiesR A Al-Hallaq
Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington DC 20007, USA
J Neurochem 77:110-9. 2001..Thus, although postsynaptic densities are highly enriched in synaptic proteins, there appears to be no selective incorporation of specific NR1 splice variants or NR2 subunits into this structure...
- PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellumA W McGee
Department of Physiology and Programs in Biomedical Sciences and Neuroscience, University of California at San Francisco School of Medicine, San Francisco, California 94143 0444, USA
J Neurosci 21:3085-91. 2001..Our data demonstrate that MAGUK proteins of the PSD-93/95 family are not essential for development of certain central synapses but may instead participate in specialized aspects of synaptic signaling and plasticity...
- Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranesM Russwurm
Pharmakologie und Toxikologie, Medizinische Fakultät MA N1, Ruhr Universitat Bochum, 44780 Bochum, Germany
J Biol Chem 276:44647-52. 2001....
- Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapsesAtsushi Inanobe
Department of Pharmacology II, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
Am J Physiol Cell Physiol 282:C1396-403. 2002..Therefore, the Kir channel may be involved in formation of the resting membrane potential of the spines and, thus, would affect the response of N-methyl-D-aspartic acid receptor channels at the excitatory postsynaptic membrane...
- Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophreniaKazuhiko Toyooka
Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
J Neurochem 83:797-806. 2002..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...
- Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardiumDavid Godreau
INSERM Unité 460, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
Cardiovasc Res 56:433-42. 2002..Here, we studied the expression and role of these anchoring proteins in human right atrial myocardium by means of various molecular, biochemical and physiological methods...
- Olivocerebellar Circuitry in AutismGene J Blatt; Fiscal Year: 2010..Co-localization of GluRo2 with PSD93 will determine the percentage of postsynaptic density and co-localization of EAAT4 with synaptophysin will ..
- Molecular Mechanisms Underlying PSD-MAGUK/NMDA Receptor InteractionsMacKenzie A Howard; Fiscal Year: 2012..abstract_text> ..
- REGULATION OF NEURONAL SYNAPTIC COMPONENTSMichele Jacob; Fiscal Year: 2009..Further, the studies will determine whether the organizational mechanisms are shared between peripheral neuron and central sensory nicotinic synapses. ..
- THOMAS J O'DELL; Fiscal Year: 2016....
- Interaction of Anesthetics with Neuronal PDZ DomainsRoger Johns; Fiscal Year: 2009....
- Mark E Bowen; Fiscal Year: 2016..Describing the molecular events in excitatory signaling is a fundamental challenge in neuroscience with direct relevance to brain development, memory and learning, and many neurological and neuropsychiatric disorders. ..
- Impact of Prenatal Alcohol Exposure on Receptor Targeting and FunctioningKevin K Caldwell; Fiscal Year: 2011....
- Roger A Nicoll; Fiscal Year: 2016..More specifically it is well established that mutations in the neuroligins are tightly linked to rare genetic forms of autism. ..
- Role of Spinal Cord PSD-93/Chapsyn-110 in Chronic PainRoger Johns; Fiscal Year: 2007..These studies will provide a novel insight to the mechanisms of chronic pain and a new and potential biochemical target for the prevention and therapy of chronic pain. [unreadable] [unreadable]..
- SYNAPTIC REGULATION OF NITRIC OXIDEDavid Bredt; Fiscal Year: 2005..On the other hand, an extended "P-finger" of the NNOS PDZ domain binds to PSD-95 and PSD-93, postsynaptic density proteins that mediate synaptic clustering of NMDA receptors. ..
- Cross Regulation of Beta-catenin and Retinoid SignalingStephen Byers; Fiscal Year: 2004..In general the work proposed tests the molecular mechanisms, and significance of, cross regulation of beta-catenin/TCF retinoid signaling pathways. ..
- APC2 AND BREAST CANCERStephen Byers; Fiscal Year: 2002..Targets of beta-catenin signaling include cyclin Dl and c-myc, both of which are commonly overexpressed in human breast cancers. We will relate the cytogenetics of APC2 to the expression of cyclin D1 and c-myc breast cancers. ..
- Modulation of parasympathetic neurons by PACAP peptidesRODNEY PARSONS; Fiscal Year: 2005....
- CENTER FOR NEUROSCIENCE EXCELLENCERodney L Parsons; Fiscal Year: 2010....
- Chemically specified synaptogenesis in the visual cortexChiye Aoki; Fiscal Year: 2004..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..
- NR3 Expression in Human BrainHelena Mueller; Fiscal Year: 2003..abstract_text> ..
- SYNAPTOGENESIS IN THE CEREBRAL CORTEXChiye Aoki; Fiscal Year: 2003..The knowledge gained from such a study is required in designing molecular remedies for deficits caused by sensory deprivation during early life. ..