DLAT

Summary

Gene Symbol: DLAT
Description: dihydrolipoamide S-acetyltransferase
Alias: DLTA, PDC-E2, PDCE2, dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, 70 kDa mitochondrial autoantigen of primary biliary cirrhosis, E2 component of pyruvate dehydrogenase complex, M2 antigen complex 70 kDa subunit, PBC, dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, pyruvate dehydrogenase complex component E2
Species: human

Top Publications

  1. ncbi Three-dimensional structure of the major autoantigen in primary biliary cirrhosis
    M J Howard
    Department of Biochemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, England
    Gastroenterology 115:139-46. 1998
  2. ncbi Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components
    Yasuaki Hiromasa
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:6921-33. 2004
  3. ncbi Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    Mary C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, Bart s and The London, Queen Mary s School of Medicine and Dentistry, University of London, Mile End Road, London E1 4NS, United Kingdom
    Am J Physiol Endocrinol Metab 284:E855-62. 2003
  4. pmc Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
    Masato Kato
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 24:1763-74. 2005
  5. pmc A DltA mutant of Haemophilus ducreyi Is partially attenuated in its ability to cause pustules in human volunteers
    Diane Janowicz
    Department of Medicine, Indiana University, Indianapolis, IN 46202 5124, USA
    Infect Immun 74:1394-7. 2006
  6. ncbi Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation
    M Perego
    Dipartimento Farmaceutico, Facolta di Farmacia, Universita degli Studi di Parma, Italy
    J Biol Chem 270:15598-606. 1995
  7. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
  8. pmc A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae
    Martá Kovács
    University of Kaiserslautern, Department of Microbiology, Paul Ehrlich Strasse 23, D 67663 Kaiserslautern, Germany
    J Bacteriol 188:5797-805. 2006
  9. ncbi Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis
    R K Thomson
    Tenovus Laboratory, and University Medicine, Southampton University Hospitals, UK
    J Hepatol 28:582-94. 1998
  10. doi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008

Research Grants

  1. MERRILL E GERSHWIN; Fiscal Year: 2015
  2. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
  3. MERRILL E GERSHWIN; Fiscal Year: 2016
  4. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
  5. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
  6. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
  7. dnTGF Beta RII Mice and PBC
    M Gershwin; Fiscal Year: 2009
  8. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
  9. Dihydrolipoamide Acyltransferase:Target for Chemotherapy
    Carl Nathan; Fiscal Year: 2004
  10. Role of Apoptotic Cholangiocytes in PBC
    JOSEPH ODIN; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications180 found, 100 shown here

  1. ncbi Three-dimensional structure of the major autoantigen in primary biliary cirrhosis
    M J Howard
    Department of Biochemistry, Cambridge Centre for Molecular Recognition, University of Cambridge, England
    Gastroenterology 115:139-46. 1998
    Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the presence of antimitochondrial autoantibodies in patients' serum...
  2. ncbi Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components
    Yasuaki Hiromasa
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    J Biol Chem 279:6921-33. 2004
    ..Twelve E3 dimers were bound per E248.E3BP12 mass, which is consistent with this model...
  3. ncbi Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs
    Mary C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, Bart s and The London, Queen Mary s School of Medicine and Dentistry, University of London, Mile End Road, London E1 4NS, United Kingdom
    Am J Physiol Endocrinol Metab 284:E855-62. 2003
    ....
  4. pmc Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
    Masato Kato
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    EMBO J 24:1763-74. 2005
    ..We hypothesize that this allosteric mechanism accounts, in part, for E2p-augmented PDK3 activity...
  5. pmc A DltA mutant of Haemophilus ducreyi Is partially attenuated in its ability to cause pustules in human volunteers
    Diane Janowicz
    Department of Medicine, Indiana University, Indianapolis, IN 46202 5124, USA
    Infect Immun 74:1394-7. 2006
    Haemophilus ducreyi produces two outer membrane proteins, called DltA (H. ducreyi lectin A) and DsrA (H. ducreyi serum resistance A), that contribute to the ability of the organism to evade complement-mediated serum killing...
  6. ncbi Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation
    M Perego
    Dipartimento Farmaceutico, Facolta di Farmacia, Universita degli Studi di Parma, Italy
    J Biol Chem 270:15598-606. 1995
    ..The dlt operon contains five genes, dltA-dltE. Insertional inactivation of dltA-dltD results in complete absence of D-alanine from both LTA and WTA...
  7. ncbi [Quantitation of antigen specific T lymphocytes in peripheral blood of patients with primary biliary cirrhosis using tetramer technology]
    Hai Ying Liu
    Clinical Laboratory, General Hospital of Guangzhou, Guangzhou 510010, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22:78-81. 2006
    To quantitate antigen specific T lymphocytes in peripheral blood from patients with primary biliary cirrhosis(PBC) and study the role of antigen specific T lymphocytes in the development of PBC.
  8. pmc A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae
    Martá Kovács
    University of Kaiserslautern, Department of Microbiology, Paul Ehrlich Strasse 23, D 67663 Kaiserslautern, Germany
    J Bacteriol 188:5797-805. 2006
    ..pneumoniae strains, the laboratory strain R6 and the clinical isolate TIGR4. The annotation of dltA in R6 predicts a protein, d-alanine-d-alanyl carrier protein ligase (Dcl), that is shorter at the amino terminus ..
  9. ncbi Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis
    R K Thomson
    Tenovus Laboratory, and University Medicine, Southampton University Hospitals, UK
    J Hepatol 28:582-94. 1998
    ..The aim of this study was to generate and characterise human anti-PDC-E2 monoclonal antibodies and analyse immunoglobulin gene usage and mutation for clues to pathogenesis...
  10. doi Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway
    Hannah R Walden
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:1874-84. 2008
    Lipoylated enzymes such as the E2 component of pyruvate dehydrogenase complex (PDC-E2) are targets for autoreactive immune responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant auto-epitopes...
  11. ncbi Peripheral tolerance and the qualitative characteristics of autoreactive T cell clones in primary biliary cirrhosis
    Akira Kawano
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Immunol 179:3315-24. 2007
    ..These data highlight that costimulation plays a dominant role in maintaining peripheral tolerance to PBC-specific Ags...
  12. ncbi Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis
    M Yasoshima
    Department of Pathology II, Kanazawa University School of Medicine, Japan
    J Pathol 175:319-25. 1995
    ..Ten cases of primary biliary cirrhosis (PBC) and 19 controls were examined, including four cases of extrahepatic biliary obstruction, six of chronic viral ..
  13. ncbi PDC-E3BP is not a dominant T-cell autoantigen in primary biliary cirrhosis
    Anna McHugh
    Liver Research Group, University of Newcastle, Newcastle upon Tyne, UK
    Liver Int 26:406-13. 2006
    ..the E2 and E3BP components of pyruvate dehydrogenase complex (PDC), which characterise primary biliary cirrhosis (PBC) crossreact, precluding the identification, from serological studies, of the antigen to which the principal ..
  14. doi Length-dependent weakness and electrophysiological signs of secondary axonal loss in chronic inflammatory demyelinating polyradiculoneuropathy
    Thomas Harbo
    Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, Aarhus C, Denmark
    Muscle Nerve 38:1036-45. 2008
    ..Conduction velocity (CV), distal latency (DLAT), minimal F-wave latency (FLAT), compound muscle action potential (CMAP), and amplitude decay between distal and ..
  15. ncbi Molecular cloning of dihydrolipoamide acetyltransferase of the rat pyruvate dehydrogenase complex: sequence comparison and evolutionary relationship to other dihydrolipoamide acyltransferases
    S Matuda
    Department of Biology, Kanoya National Institute of Fitness and Sports, Japan
    Biochim Biophys Acta 1131:114-8. 1992
    ..The E2 components of the three alpha-ketoacid dehydrogenase complexes are suggested to be classified into three clusters separated during evolution...
  16. ncbi The human biliary epithelial cell plasma membrane antigen in primary biliary cirrhosis: pyruvate dehydrogenase X?
    R E Joplin
    University Hospital, and Department of Medicine, University of Birmingham, England
    Gastroenterology 113:1727-33. 1997
    Patients with primary biliary cirrhosis (PBC) have autoantibodies that react with components of mitochondrial multienzyme complexes...
  17. pmc Molecular basis of resistance to muramidase and cationic antimicrobial peptide activity of lysozyme in staphylococci
    Silvia Herbert
    Microbial Genetics Department, University of Tubingen, Tubingen, Germany
    PLoS Pathog 3:e102. 2007
    ..7% decrease in the content of esterified d-alanyl groups in teichoic acids. The oatA/dltA double mutant showed the highest sensitivity to lysozyme; this mutant completely lacks teichoic acid-bound d-..
  18. ncbi Enhanced secretion of heterologous cyclodextrin glycosyltransferase by a mutant of Bacillus licheniformis defective in the D-alanylation of teichoic acids
    M Craynest
    Vaccine Development Laboratory, National Public Health Institute, Helsinki, Finland
    Lett Appl Microbiol 37:75-80. 2003
    ..To examine whether inactivation of the dlt operon and increased charge density of the wall enhances secretion of heterologous proteins in industrial strains of Bacillus licheniformis...
  19. ncbi The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    M Eric Gershwin
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 47:737-45. 2008
    ..Primary biliary cirrhosis (PBC) is considered a model autoimmune disease because of its signature antimitochondrial autoantibody (AMA), the ..
  20. pmc Defects in D-alanyl-lipoteichoic acid synthesis in Streptococcus mutans results in acid sensitivity
    D A Boyd
    Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Bacteriol 182:6055-65. 2000
    ..3-kb deletion, one end of which was in dltB of the dlt operon encoding four proteins (DltA-DltD) involved in the synthesis of D-alanyl-lipoteichoic acid...
  21. ncbi D-alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract
    Jens Walter
    Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, New Zealand
    Environ Microbiol 9:1750-60. 2007
    ..Insertional inactivation of the dltA gene resulted in complete depletion of D-alanine substitution of lipoteichoic acids...
  22. ncbi The pathogenesis of primary biliary cirrhosis
    J A Solis Herruzo
    Department of Digestive Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain
    Rev Esp Enferm Dig 101:413-23. 2009
    Primary biliary cirrhosis (PBC) would develop when the immune system comes across a microorganism with proteins similar to those in the piruvate dehydrogenase complex E2 (PDC-E2), or a neoantigen resulting from a xenobiotic-modified ..
  23. doi dltA gene mutation in the teichoic acids alanylation system of Lactococcus garvieae results in diminished proliferation in its natural host
    P Reimundo
    Area de Microbiologia, Departamento de Biologia Funcional, Facultad de Medicina, IUBA, Universidad de Oviedo, 33006 Oviedo, Asturias, Spain
    Vet Microbiol 143:434-9. 2010
    ..the role of this alanylation in the physiology and virulence of Lactococcus garvieae, a previously isolated dltA Delta Tn917 signature tagged mutagenesis (STM) clone was analyzed...
  24. doi Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus
    Yukichika Tabuchi
    Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Immunol 185:2424-31. 2010
    ..A mutation of dltA, which is responsible for the D-alanylation of teichoic acids, brought about an increase in the survival rate of ..
  25. doi New ELISA for detecting primary biliary cirrhosis-specific antimitochondrial antibodies
    Cornelia Dähnrich
    EUROIMMUN AG, Lubeck, Germany
    Clin Chem 55:978-85. 2009
    Antimitochondrial antibodies specific for primary biliary cirrhosis (PBC) target the E2 subunits of 2-oxo acid dehydrogenase complexes, in particular the pyruvate dehydrogenase complex (PDC)-E2...
  26. doi Crystal structure of Bacillus cereus D-alanyl carrier protein ligase (DltA) in complex with ATP
    Khan Tanjid Osman
    Department of Biochemistry, University of Saskatchewan, A3 Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    J Mol Biol 388:345-55. 2009
    ..Disruption of the bacterial dlt operon involved in teichoic acid alanylation, as well as inhibition of the DltA (D-alanyl carrier protein ligase) protein, has been shown to render the bacterium more susceptible to conventional ..
  27. pmc Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis
    R Klein
    Medizinische Klinik, University of Tubingen, Germany
    Clin Exp Immunol 92:308-16. 1993
    Anti-M2 antibodies in primary biliary cirrhosis (PBC) have been shown to react with the alpha-ketoacid dehydrogenase complex of the inner mitochondrial membrane consisting of six epitopes (E2 subunit of the pyruvate dehydrogenase complex ..
  28. ncbi Antimitochondrial antibodies in primary biliary cirrhosis
    P S Leung
    Division of Rheumatology Allergy and Clinical Immunology, University of California, Davis 95616, USA
    Semin Liver Dis 17:61-9. 1997
    ..last decade, the cloning and biochemical identification of mitochondrial autoantigens in primary biliary cirrhosis (PBC) as members of the 2-oxoacid dehydrogenase complex has greatly advanced the detection of antimitochondrial ..
  29. ncbi KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:145-50. 2003
    ..KIAA1735 gene, consisting of 16 exons, was about 45 kb in size. KIAA1735 gene was linked to DLAT gene in tail-to-head manner with an interval less than 4.0 kb. KIAA1735 gene on human chromosome 11q23...
  30. ncbi Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium
    Carlo Selmi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Hepatology 38:1250-7. 2003
    Infectious and environmental agents have been proposed as immunologic triggers for primary biliary cirrhosis (PBC)...
  31. pmc Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis
    Jamal A Mohamed
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical School, Houston, Texas 77030, USA
    Infect Immun 72:3658-63. 2004
    ..001). Mutants disrupted in dltA, efaA, ace, lsa, and six two-component regulatory systems were largely unaltered, while disruptions in epa (..
  32. ncbi Amino acids critical for binding of autoantibody to an immunodominant conformational epitope of the pyruvate dehydrogenase complex subunit E2: identification by phage display and site-directed mutagenesis
    Marita Scealy
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton, VIC 3800, Australia
    Mol Immunol 43:745-53. 2006
    ..pyruvate dehydrogenase complex (PDC-E2) is the major autoantigen in the liver disease, primary biliary cirrhosis (PBC)...
  33. pmc NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
    Junichiro Irie
    Division of Rheumatology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 203:1209-19. 2006
    Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis...
  34. pmc Cation-induced transcriptional regulation of the dlt operon of Staphylococcus aureus
    Tomaz Koprivnjak
    Inflammation Program, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, 52242, USA
    J Bacteriol 188:3622-30. 2006
    ..reverse transcription-PCR, and SMART-RACE analyses suggest that the dlt transcript begins 250 bp upstream of the dltA start codon and includes an open reading frame immediately upstream of dltA...
  35. ncbi Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-beta receptor II dominant-negative mice
    Sabine Oertelt
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA
    J Immunol 177:1655-60. 2006
    Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by lymphocytic infiltrates in portal tracts, selective destruction of biliary epithelial cells, and anti-mitochondrial Abs (AMAs)...
  36. ncbi [Opioid receptors and their selective ligands]
    Mariola Katarzyna Piestrzeniewicz
    Laboratory of Biomolecular Chemistry, Institute of Biomedicinal Chemistry, Medical University of Łódź, 6 8Mazowiecka St, 92 215 Łódź, Poland
    Postepy Biochem 52:313-9. 2006
    ..All these modifications resulted in obtaining very selective agonists and antagonists with high affinity at micro-, dlta-, and kappa-opioid receptors, which are extremely useful tools in further studies on the pharmacology of opioid ..
  37. ncbi Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis
    Minoru Nakamura
    National Hospital Organization NHO Nagasaki Medical Center, Omura Nagasaki University Graduate School of Biomedical Sciences, Nagasaki and National Hospital Organization Study Group for Liver Disease in Japan NHOSLJ, Fukuoka, Japan
    Hepatol Res 37:S412-9. 2007
    ..gp210 and sp100, we studied the clinical significance of antinuclear antibodies (ANA) in primary biliary cirrhosis (PBC) patients registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ)...
  38. ncbi Possible involvement of queuine in regulation of cell proliferation
    Chandramani Pathak
    School of Studies in Biochemistry, Jiwaji University, Gwalior, India
    Biofactors 29:159-73. 2007
    ..For this DLAT cancerous mouse, U87 cell line and HepG2 cell line are treated with different concentrations of queuine and the ..
  39. doi Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis
    Dimitrios Bogdanos
    Institute of Liver Studies, King s College, London School of Medicine at King s College Hospital, London, United Kingdom
    J Hepatol 49:466-73. 2008
    ..other mitochondrial 2-oxoacid dehydrogenases (AMA-M2) are the hallmark for diagnosis of primary biliary cirrhosis (PBC)...
  40. pmc Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes
    Kathleen H Cox
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 4:e5366. 2009
    ..In this study, we have further investigated the effects that mutating dltA has on virulence factor expression in Streptococcus pyogenes.
  41. doi Murine models of autoimmune cholangitis
    Yoshiyuki Ueno
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Curr Opin Gastroenterol 26:274-9. 2010
    Primary biliary cirrhosis (PBC) is a human autoimmune liver disease whose molecular pathogenesis is poorly understood because of the difficulty in accessing human tissue and the absence of appropriate animal models...
  42. pmc Correlation of daptomycin resistance in a clinical Staphylococcus aureus strain with increased cell wall teichoic acid production and D-alanylation
    Ute Bertsche
    Interfacultary Institute of Microbiology and Infection Medicine, Microbial Genetics, University of Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Antimicrob Agents Chemother 55:3922-8. 2011
    ..05 in comparing strain 616 versus strain 701). The latter phenotypic findings correlated with (i) enhanced tagA and dltA gene expression, respectively, and (ii) an increase in surface positive charge observed in the daptomycin-resistant ..
  43. pmc Bacillus subtilis σ(V) confers lysozyme resistance by activation of two cell wall modification pathways, peptidoglycan O-acetylation and D-alanylation of teichoic acids
    Veronica Guariglia-Oropeza
    Department of Microbiology, 370 Wing Hall, Cornell University, Ithaca, NY 14853, USA
    J Bacteriol 193:6223-32. 2011
    ..with respect to lysozyme sensitivity: single mutants are not affected in lysozyme sensitivity, whereas an oatA dltA double mutant is as sensitive as a sigV null strain...
  44. pmc Modulating activity of vancomycin and daptomycin on the expression of autolysis cell-wall turnover and membrane charge genes in hVISA and VISA strains
    Viviana Cafiso
    Unit of Microbiology, Department of Bio Medical Sciences University of Catania, Catania, Italy
    PLoS ONE 7:e29573. 2012
    ..expression of genes involved in autolysis (atl-lytM), cell-wall turnover (sceD), membrane charges (mprF-dltA) and regulatory mechanisms (agr-locus-graRS-walKR), in hVISA and VISA cultured with or without vancomycin and ..
  45. doi Catalase and estradiol inhibit mitochondrial protein S-glutathionylation
    Bin Hu
    Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 367:51-8. 2012
    ..This effect may play a role in ninefold greater prevalence of autoantibodies against PDC-E2 in women with primary biliary cirrhosis...
  46. doi Immunological orchestration of liver fibrosis
    Hajime Tanaka
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    Clin Rev Allergy Immunol 43:220-9. 2012
    ..Primary biliary cirrhosis (PBC) is a unique chronic, fibrosing liver disease affecting predominantly women and characterized by an immune-mediated ..
  47. pmc Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex
    Jinjun Wang
    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, Davis, CA 95616, USA
    J Immunol 191:2126-33. 2013
    ..Collectively, the AMA binding studies and EPR analysis demonstrate the necessity of the lipoyl β-sheet structural conformation in anti-PDC-E2 recognition. ..
  48. pmc Phenylbutyrate increases pyruvate dehydrogenase complex activity in cells harboring a variety of defects
    Rosa Ferriero
    Telethon Institute of Genetics and Medicine Naples, Italy
    Ann Clin Transl Neurol 1:462-70. 2014
    ..have defects in the X-linked E1-α gene but defects in the other components of the complex encoded by PDHB, PDHX, DLAT, DLD genes or in the regulatory enzyme encoded by PDP1 have also been found...
  49. pmc Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
    Rommel A Mathias
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, 3086, Australia
    Cell 159:1615-25. 2014
    ..SIRT4 enzymatically hydrolyzes the lipoamide cofactors from the E2 component dihydrolipoyllysine acetyltransferase (DLAT), diminishing PDH activity...
  50. doi Etiopathogenesis of primary biliary cirrhosis: an overview of recent developments
    Palak J Trivedi
    Centre for Liver Research and NIHR Liver Biomedical Research Unit, University of Birmingham, 5th Floor, Institute for Biomedical Research, Wolfson Drive, Birmingham, B15 2TT, UK
    Hepatol Int 7:28-47. 2013
    Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease...
  51. doi The lysine-peptoid hybrid LP5 maintain activity under physiological conditions and affects virulence gene expression in Staphylococcus aureus
    Sanne Gottschalk
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, DK 1870 Frederiksberg, Denmark Electronic address
    Peptides 78:24-9. 2016
    ..aureus toward antimicrobial peptides, we found that LP5 was protease resistant. However, the dltA and vraF genes, involved in reducing the net anionic charge of the bacterial cell envelope and sensing of ..
  52. pmc D-Alanylation of Teichoic Acids and Loss of Poly-N-Acetyl Glucosamine in Staphylococcus aureus during Exponential Growth Phase Enhance IL-12 Production in Murine Dendritic Cells
    Lisbeth Drozd Lund
    Department of Veterinary Disease Biology, University of Copenhagen, Frederiksberg, Denmark
    PLoS ONE 11:e0149092. 2016
    ..Furthermore, the mutant dltA unable to produce D-alanylated teichoic acids failed to induce IL-12 but like peptidoglycan and the toll-like ..
  53. pmc E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis
    Perrine Goguet-Rubio
    Institut de Recherche en Cancérologie de Montpellier, Montpellier F 34298, France INSERM U1194, Montpellier F 34298, France University of Montpellier, Montpellier F 34090, France Institut régional du Cancer de Montpellier, Montpellier F 34298, France Equipe Labellisée Ligue Contre le Cancer, 75013 Paris, France
    Proc Natl Acad Sci U S A 113:11004-9. 2016
    ..E4F1 deficiency in basal keratinocytes resulted in deregulated expression of dihydrolipoamide acetyltransferase (Dlat), a gene encoding the E2 subunit of the mitochondrial pyruvate dehydrogenase (PDH) complex...
  54. ncbi Cryptic antigenic determinants on the extracellular pyruvate dehydrogenase complex/mimeotope found in primary biliary cirrhosis. A probe by affinity mass spectrometry
    T T Yip
    Department of Food Science and Technology, Allergy and Clinical Immunology, University of California Davis, School of Medicine, Davis, California 95616, USA
    J Biol Chem 271:32825-33. 1996
    Affinity mass spectrometry (AMS) was used to evaluate the structural diversity of the E2 component of pyruvate dehydrogenase complex (PDC) in normal and diseased liver cells, including those from patients with the autoimmune disease ..
  55. ncbi Breakdown of tolerance to pyruvate dehydrogenase complex in experimental autoimmune cholangitis: a mouse model of primary biliary cirrhosis
    D E Jones
    Centre for Liver Research, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Hepatology 30:65-70. 1999
    The autoimmune liver disease primary biliary cirrhosis (PBC) is characterized by autoreactive responses to a highly conserved self-antigen, pyruvate dehydrogenase complex (PDC)...
  56. ncbi The peculiar autoimmunity of primary biliary cirrhosis
    I R Mackay
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Immunol Rev 174:226-37. 2000
    Autoantibodies to mitochondria (AMA, anti-M2) are a serologic hallmark of primary biliary cirrhosis (PBC)...
  57. pmc Regulation of D-alanyl-lipoteichoic acid biosynthesis in Streptococcus agalactiae involves a novel two-component regulatory system
    C Poyart
    Laboratoire de Microbiologie, INSERM U 411, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    J Bacteriol 183:6324-34. 2001
    The dlt operon of gram-positive bacteria comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids (LTAs)...
  58. ncbi Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2 against Staphylococcus aureus
    Tomaz Koprivnjak
    Department of Microbiology, University of Iowa, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa 52246, USA
    J Biol Chem 277:47636-44. 2002
    ..aureus, we examined the effects of mutations that prevent specific modifications of cell wall (dltA) and cell membrane (mprF) polyanions...
  59. pmc Autoimmune cholangitis in the SJL/J mouse is antigen non-specific
    Motoko Sasaki
    Division of Rheumatology, Allergy and Clinical Immunology, University of California School of Medicine, Davis, CA 95616, USA
    Dev Immunol 9:103-11. 2002
    Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by intrahepatic bile duct destruction and the production of anti-mitochondrial antibodies (AMA)...
  60. pmc The Bacillus subtilis extracytoplasmic-function sigmaX factor regulates modification of the cell envelope and resistance to cationic antimicrobial peptides
    Min Cao
    Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
    J Bacteriol 186:1136-46. 2004
    ..Consistent with this notion, we find that both sigX and dltA mutants are more sensitive to nisin than wild-type cells...
  61. ncbi Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis
    Shuji Matsumura
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 39:1415-22. 2004
    ..antibodies (AMAs) have long been recognized as a serological hallmark of primary biliary cirrhosis (PBC)...
  62. pmc A novel lectin, DltA, is required for expression of a full serum resistance phenotype in Haemophilus ducreyi
    Isabelle Leduc
    Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Infect Immun 72:3418-28. 2004
    ..ducreyi. We describe here a second outer membrane protein, DltA (for ducreyi lectin A), which also contributes to serum resistance in H. ducreyi...
  63. ncbi Autoimmune epitopes: autoepitopes
    Ian R Mackay
    Department of Biochemistry and Molecular Biology, Monash University Clayton, 3800, Victoria, Australia
    Autoimmun Rev 3:487-92. 2004
    ..The latter is illustrated by our studies on the autoepitope for anti-PDC-E2 (AMA) in primary biliary cirrhosis (PBC), anti-GAD65 in type 1 diabetes, and anti-C1 of type II collagen in collagen-induced arthritis...
  64. ncbi The Western immunoblotting pattern of anti-mitochondrial antibodies is independent of the clinical expression of primary biliary cirrhosis
    L Muratori
    Department of Internal Medicine, Cardioangiology and Hepatology, Alma Mater Studiorum, University of Bologna, Policlinico Sant Orsola Malpighi, Via Massarenti, 9, 40138 Bologna, Italy
    Dig Liver Dis 37:108-12. 2005
    ....
  65. ncbi IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis
    Kanji Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 44:1240-9. 2006
    ..receptor alpha (IL-2Ralpha, CD25) expression who had several clinical manifestations of primary biliary cirrhosis (PBC)...
  66. ncbi Hypomodification of transfer RNA in cancer with respect to queuosine
    Chandramani Pathak
    School of Studies in Biochemistry, Jiwaji University, Gwalior, India
    RNA Biol 2:143-8. 2005
    ..modification of transfer RNA and TGTase activity is compared in normal, Dalton's lymphoma ascites transplanted (DLAT) cancerous and queuine treated DLAT cancerous mouse liver...
  67. ncbi Queuine mediated inhibition in phosphorylation of tyrosine phosphoproteins in cancer
    Chandramani Pathak
    Biochemistry and Molecular Biology Laboratory, Center of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India
    Mol Biol Rep 35:369-74. 2008
    ..The result shows high level of cytosolic and membrane associated tyrosine phosphoprotein in DLAT cancerous mouse liver compared to normal...
  68. ncbi [The effect of metabolites on the pH gradient and membrane potential of the bean peribacteroid membrane]
    V V Krylova
    Prikl Biokhim Mikrobiol 43:325-30. 2007
    ..The obtained data on the changes in deltapH and dlta psi caused by the metabolites in question suggest that PBM is permeable for all these metabolites only in young ..
  69. ncbi Apoptosis-associated antigens recognized by autoantibodies in patients with the autoimmune liver disease primary biliary cirrhosis
    Christoph Peter Berg
    Department of Internal Medicine I, Medical Clinic, Eberhard Karls University, Otfried Mueller Strasse 10, Tuebingen, Germany
    Apoptosis 13:63-75. 2008
    ..to investigate, whether antibodies from patients with the autoimmune liver disease primary biliary cirrhosis (PBC) recognize self-proteins generated and released during apoptosis...
  70. ncbi Primary biliary cirrhosis and autoantibodies
    K Miyachi
    Keigu Clinic, Department of Internal Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 31:47-55. 2008
    Fifty years have passed since anti-mitochondrial antibodies were found in patients with primary biliary cirrhosis (PBC)...
  71. pmc Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization
    K Wakabayashi
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA 95616, USA
    Clin Exp Immunol 155:577-86. 2009
    ..to an anti-mitochondrial antibody response and autoimmune cholangitis, similar to human primary biliary cirrhosis (PBC)...
  72. pmc Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly
    S Vijayakrishnan
    Division of Molecular and Cell Biology, Faculty of Biomedical and Life Sciences, Davidson Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Mol Biol 399:71-93. 2010
    ..The architectural complexity and lower stability of the E2/E3BP core may be of benefit to mammals, where sophisticated fine-tuning is required for cores with optimal catalytic and regulatory efficiencies...
  73. pmc Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis
    Ana Lleo
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA, USA
    Hepatology 52:987-98. 2010
    Our understanding of primary biliary cirrhosis (PBC) has been significantly enhanced by the rigorous dissection of the multilineage T and B cell response against the immunodominant mitochondrial autoantigen, the E2 component of the ..
  74. doi Ex12 helper phage improves the quality of a phage-displayed antibody library by ameliorating the adverse effect of clonal variations
    Hyo jung Choi
    Department of Systems Immunology, College of Biomedical Science, Kangwon National University, Korea
    BMB Rep 44:244-9. 2011
    ..Using the human Fab SP114 against the pyruvate dehydrogenase complex-E2 (PDCE2), we created four E...
  75. doi Approaches to the pathogenesis of primary biliary cirrhosis through animal models
    Axel R Concepcion
    Division of Gene Therapy and Hepatology, CIMA, Clinic and School of Medicine University of Navarra, and CIBEREHD, Pamplona, Spain
    Clin Res Hepatol Gastroenterol 36:21-8. 2012
    Primary biliary cirrhosis (PBC) is a chronic and progressive cholestatic liver disease of unknown etiopathogenesis that mainly affects middle-aged women...
  76. pmc The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I:C) and murine autoimmune cholangitis
    Y M Ambrosini
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, Davis, CA 95616, USA
    Clin Exp Immunol 166:110-20. 2011
    A void in understanding primary biliary cirrhosis (PBC) is the absence of appropriate animal models...
  77. pmc Primary biliary cirrhosis and Sjögren's syndrome: autoimmune epithelitis
    Carlo Selmi
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis, CA, USA
    J Autoimmun 39:34-42. 2012
    Primary biliary cirrhosis (PBC) has been often coined a model autoimmune disease based on the homogeneity amongst patients, the frequency and similarity of antimitochondrial antibodies, including the highly directed immune response to ..
  78. pmc Characterization of a regulatory network of peptide antibiotic detoxification modules in Lactobacillus casei BL23
    Ainhoa Revilla-Guarinos
    Departamento de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Paterna, Valencia, Spain
    Appl Environ Microbiol 79:3160-70. 2013
    ..Furthermore, the characterization of a dltA mutant showed that Dlt plays a major role in AMP resistance in L. casei...
  79. pmc Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk
    I Ting Chow
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Immunol 190:4516-24. 2013
    ..DR1101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary cirrhosis (PBC)...
  80. pmc Role of cholangiocytes in primary biliary cirrhosis
    Ana Lleo
    Liver Unit and Center for Autoimmune Liver Diseases, Humanitas Clinical and Research Center, Rozzano MI, Italy
    Semin Liver Dis 34:273-84. 2014
    Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterized by selective destruction of intrahepatic cholangiocytes...
  81. pmc Phenotypic and genotypic characterization of daptomycin-resistant methicillin-resistant Staphylococcus aureus strains: relative roles of mprF and dlt operons
    Nagendra N Mishra
    Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, United States of America The David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 9:e107426. 2014
    ..e., dysregulation of dltA and mprF), (ii) a significant increase in the D-alanylated wall teichoic acid (WTA) content in DAP-R strains, ..
  82. pmc Site-specific mutation of the sensor kinase GraS in Staphylococcus aureus alters the adaptive response to distinct cationic antimicrobial peptides
    Ambrose L Cheung
    Department of Microbiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA
    Infect Immun 82:5336-45. 2014
    ..The ΔgraS and ΔEL strains were unable to induce mprF and dltA expression and, in turn, demonstrated significantly increased susceptibilities to daptomycin, polymyxin B, and two ..
  83. pmc Difficulties in recognition of pyruvate dehydrogenase complex deficiency on the basis of clinical and biochemical features. The role of next-generation sequencing
    E Ciara
    Department of Medical Genetics, The Children s Memorial Health Institute, Warsaw, Poland
    Mol Genet Metab Rep 7:70-6. 2016
    ..defect is a well-known cause of mitochondrial disorders (MD) with at least six responsible genes (PDHA1, PDHB, DLAT, DLD, PDHX, PDP1)...
  84. doi The dlt genes play a role in antimicrobial tolerance of Streptococcus mutans biofilms
    Martin Nilsson
    Costerton Biofilm Centre, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Copenhagen DK 2200, Denmark
    Int J Antimicrob Agents 48:298-304. 2016
    ..mutans biofilms towards gentamicin. The minimum bactericidal concentration for biofilm cells (MBC-B) for a dltA transposon mutant was eight-fold lower than that of the wild-type...
  85. pmc E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity
    Matthieu Lacroix
    Institut de Recherche en Cancérologie de Montpellier, Montpellier F 34298, France INSERM, U1194, Montpellier F 34298, France Université Montpellier, Montpellier F 34090, France Institut du Cancer Montpellier, Montpellier F 34298, France Equipe Labellisée Ligue Contre le Cancer, 75013 Paris, France
    Proc Natl Acad Sci U S A 113:10998-1003. 2016
    ..E4F1 controls a set of four genes [dihydrolipoamide acetlytransferase (Dlat), dihydrolipoyl dehydrogenase (Dld), mitochondrial pyruvate carrier 1 (Mpc1), and solute carrier family 25 member ..
  86. pmc The Fingerprint of Antimitochondrial Antibodies and the Etiology of Primary Biliary Cholangitis
    Zongwen Shuai
    Division of Rheumatology Allergy and Clinical Immunology, University of California Davis School of Medicine, Davis, California, USA
    Hepatology . 2017
    ..Interestingly, this unique AMA subfraction is of the IgM isotype and more dominant in early stage PBC, suggesting that exposure to 2OA-PPL-like compounds occurs early in the generation of AMA...
  87. ncbi A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region
    B E Baysal
    Department of Psychiatry, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Eur J Hum Genet 9:121-9. 2001
    ..positional information for 33 ESTs and known genes, including KIAA1391, POU2AF1 (OBF1), PPP2R1B, CRYAB, HSPB2, DLAT, IL-18, PTPS, KIAA0781 and KAIA4591, which is mapped by NotI site cloning...
  88. ncbi Immunopathogenesis of primary biliary cirrhosis
    Akiyoshi Nishio
    Department of Gastroenterology, Tenri Hospital, Nara, Japan
    Semin Liver Dis 22:291-302. 2002
    ..been defined and epitope mapped for both autoreactive B and T cells, the pathogenesis of primary biliary cirrhosis (PBC) still remains a mystery. The data gathered so far address several important aspects of this intriguing puzzle...
  89. pmc A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet
    Michael R Taylor
    Department of Biochemistry, University of Washington, Seattle, WA 98195 7350, USA
    Proc Natl Acad Sci U S A 101:4584-9. 2004
    ..Here we report that noa is deficient for dihydrolipoamide S-acetyltransferase (Dlat), the PDH E2 subunit, and exhibits phenotypes similar to human patients with PDH deficiency...
  90. ncbi [Prediction and identification of autoepitopes of PDC-E2 specific CD8+ CTL in primary biliary cirrhosis patients]
    Hai Ying Liu
    Department of Experimental Diagnosis, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 26:500-4. 2004
    To identify autoepitopes of E2 subunit of pyruvate dehydrogenase complex (PDC-E2) specific CD8+ CTL in primary biliary cirrhosis (PBC) patients.
  91. pmc Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice
    Ling Jin
    Department of Biomedical Sciences, Oregon State University Corvallis, Oregon, USA
    J Neurovirol 14:389-400. 2008
    ..We have shown that LAT has antiapoptosis activity and demonstrated that the chimeric virus, dLAT-cpIAP, resulting from replacing LAT with the baculovirus antiapoptosis gene cpIAP, has a wild-type HSV-1 ..
  92. pmc Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis
    Sandra Braun
    Department of Internal Medicine II, University of Tuebingen, Otfried Muller Str 10, 72076 Tuebingen, Germany
    World J Gastroenterol 16:973-81. 2010
    To search for further immunodominant peptides of the pyruvate dehydrogenase complex E2-component (PDC-E2) recognized by antimitochondrial antibodies (AMA) in primary biliary cirrhosis (PBC).
  93. doi Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms
    Y Mazda
    Department of Oral Microbiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Mol Oral Microbiol 27:124-35. 2012
    ..Because dltA-D (teichoic acid biosynthesis) was reported to affect the susceptibility to AMPs in other bacterial species, we ..
  94. pmc Heterogeneity of genetic pathways toward daptomycin nonsusceptibility in Staphylococcus aureus determined by adjunctive antibiotics
    Andrew D Berti
    University of Wisconsin Madison School of Pharmacy, Pharmacy Practice Division, Madison, Wisconsin, USA
    Antimicrob Agents Chemother 59:2799-806. 2015
    ..to examine the influence of antibiotic combinations on the development of mutations in specific genes (mprF, rpoBC, dltA, cls2, and yycFG) previously associated with DNS...
  95. ncbi Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis
    Dimitrios Petrou Bogdanos
    Immunology Group, Institute of Hepatology, University College London Medical School and Hospitals, Harold Samuel House, 69 75 Chenies Mews, London WC1E 6HX, UK
    J Hepatol 36:14-21. 2002
    ..coli) are uniquely present in primary biliary cirrhosis (PBC)...
  96. pmc Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, California 95616, USA
    J Clin Invest 109:1231-40. 2002
    While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is mediated by autoreactive T cells infiltrating the intrahepatic ..
  97. ncbi Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis
    Jun Ichi Masuda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Japan
    Autoimmunity 35:135-41. 2002
    ..AMA), can be detected by immunoblotting in patients with liver diseases other than primary biliary cirrhosis (PBC), who are negative for AMA by conventional indirect immunofluorescence...
  98. ncbi Cloning of murine PDC-E2 gene and generation of PDC-E2 overexpressing cell line: a key step to clarify the pathogenesis of PBC?
    Hiromi Ishibashi
    J Gastroenterol 37:494-5. 2002
  99. ncbi Analysis of TCR antagonism and molecular mimicry of an HLA-A0201-restricted CTL epitope in primary biliary cirrhosis
    Hiroto Kita
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, 95616, USA
    Hepatology 36:918-26. 2002
    Although the etiology and mechanism of primary biliary cirrhosis (PBC) is unknown, growing evidence suggests a major role for T cells...
  100. ncbi Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies
    Patrick S C Leung
    Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    J Immunol 170:5326-32. 2003
    ..complex (PDC-E2) is the major autoantigen recognized by antimitochondrial Abs (AMA) in primary biliary cirrhosis (PBC)...
  101. ncbi Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis
    Takashi Kamihira
    Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3 101 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gastroenterology 125:1379-87. 2003
    ..characteristics of autoreactive costimulation-independent or CD4+ CD28- T cells in primary biliary cirrhosis (PBC) by taking advantage of the well-defined immunodominant autoepitope of the E2 component of pyruvate dehydrogenase (..

Research Grants13

  1. MERRILL E GERSHWIN; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): PBC is an autoimmune liver disease characterized by a targeted immune response to small biliary epithelial cells (BEC) and the presence of antimitochondrial autoantibodies (AMAs), which react ..
  2. MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    b>PBC is an autoimmune liver disease characterized by intrahepatic bile duct obstruction and antimitochondrial autoantibodies (AMAs)...
  3. MERRILL E GERSHWIN; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): We submit that primary biliary cirrhosis (PBC) is an environmentally induced autoimmune disease in genetically susceptible hosts, initiated by breach of tolerance to the major mitochondrial ..
  4. Retrovirus Isolation from Primary Biliary Cirrhosis
    Andrew Mason; Fiscal Year: 2004
    Approximately 1 in 2,000 women above the age of 50 develop primary biliary cirrhosis (PBC). There is no cure for this progressive hepatobiliary disease, which is one of the major indications for liver transplantation in the US...
  5. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    ..regulates the non-replicating dormant state of Mtb and to elucidate the role of dihydrolipoamide acyltransferase (DlaT), a mycobacterial component of pyruvate dehydrogenase (PDH) and peroxynitrite reductase, in this pathway for the ..
  6. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL GERSHWIN; Fiscal Year: 2001
    Primary biliary cirrhosis (PBC) is an autoimmune disease that primarily affects women and includes destruction of intrahepatic bile ducts and antimitochondrial antibodies (AMAs)...
  7. dnTGF Beta RII Mice and PBC
    M Gershwin; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Primary biliary cirrhosis (PBC) is a liver specific autoimmune disease, characterized by portal tract lymphocytic infiltration, selective destruction of biliary epithelial cells and the presence of ..
  8. FELLOWSHIPS FOR STUDENTS WITH DISABILITIES
    ANGELA FOREMAN; Fiscal Year: 2006
    b>PBC is an autoimmune liver disease characterized by obstruction of intrahepatic bile ducts and high titer antimitochondrial autoantibodies (AMA). The predominant autoantigen is PDC-E2...
  9. Dihydrolipoamide Acyltransferase:Target for Chemotherapy
    Carl Nathan; Fiscal Year: 2004
    ..helps to protect the bacillus against oxidative/nitrosative stress: Rv2215 or dihydrolipoamide acyltransferase (DLAT) (formerly "SucB")...
  10. Role of Apoptotic Cholangiocytes in PBC
    JOSEPH ODIN; Fiscal Year: 2005
    ..clinical experience of the past fourteen years have laid the foundation for success in studying the pathogenesis of PBC. The combination of a Ph.D. and M.D...
  11. BORAGE OIL AND GINKGO BILOBA (EGb 761) IN ASTHMA
    MERRILL GERSHWIN; Fiscal Year: 2004
    ..It is hoped that findings from these studies will evolve relatively non-toxic therapeutic alternatives for attenuating bronchial hyperresponsiveness and inflammation in patients with asthma. ..
  12. THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2010
    rimary biliary cirrhosis (PBC) is an enigmatic, liver specific, autoimmune disease characterized by antimito- chondrial antibodies and progressive destruction of intrahepatic bile ducts...
  13. Analysis of Tuberous Sclerosis Complex in Zebrafish
    Michael Taylor; Fiscal Year: 2007
    ..This proposal may provide clues into the causes of epilepsy in TSC and identify biochemical targets for treating this disease. [unreadable] [unreadable] [unreadable]..