DIRAS2

Summary

Gene Symbol: DIRAS2
Description: DIRAS family GTPase 2
Alias: Di-Ras2, GTP-binding protein Di-Ras2, DIRAS family, GTP-binding RAS-like 2, distinct subgroup of the Ras family member 2
Species: human

Top Publications

  1. pmc Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides
    Yoshitaka Ogita
    From the Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 290:20245-56. 2015
  2. pmc Functional Impact of An ADHD-Associated DIRAS2 Promoter Polymorphism
    Lena Grünewald
    Department of Psychiatry, Psychosomatics and Psychotherapy, Translational Psychiatry, University Hospital Frankfurt, Frankfurt, Germany
    Neuropsychopharmacology 41:3025-3031. 2016
  3. ncbi Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties
    Kenji Kontani
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Biol Chem 277:41070-8. 2002
  4. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
  5. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011

Research Grants

Scientific Experts

  • S Seshadri
  • Andreas Reif
  • Lena Grünewald
  • Yoshitaka Ogita
  • Kenji Kontani
  • Toshiaki Katada
  • Elisabeth Toverud Landaas
  • Sarah Kittel-Schneider
  • Marcel Romanos
  • Heike Weber
  • Julia Geissler
  • Elisabeth Binder
  • Christoph Schartner
  • Simone Röh
  • Klaus Peter Lesch
  • Carina Quast
  • Arisa Ebihara
  • Sachiko Egami
  • Nami Ueda
  • Minoru Tada
  • Tomohiro Ogawa
  • Yasuhiro Araki
  • Takuro Okai
  • Kota Saito

Detail Information

Publications5

  1. pmc Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides
    Yoshitaka Ogita
    From the Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 290:20245-56. 2015
    ..This leads to increased Di-Ras2 stability. We thus propose that isoprenylated Di-Ras2 forms a tight complex with SmgGDS in cytosol immediately after its synthesis, which lowers its affinity for guanine nucleotides. ..
  2. pmc Functional Impact of An ADHD-Associated DIRAS2 Promoter Polymorphism
    Lena Grünewald
    Department of Psychiatry, Psychosomatics and Psychotherapy, Translational Psychiatry, University Hospital Frankfurt, Frankfurt, Germany
    Neuropsychopharmacology 41:3025-3031. 2016
    The DIRAS2 gene is coding for a small Ras GTPase with so far unknown function...
  3. ncbi Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties
    Kenji Kontani
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Biol Chem 277:41070-8. 2002
    ..Interestingly, introduction of Di-Ras into HEK293T cells induces large cellular vacuolation. These findings raise the possibility that Di-Ras might regulate cell morphogenesis in a manner distinct from other members of Ras family...
  4. pmc Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
    Sudha Seshadri
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S15. 2007
    ..We conducted a genome-wide association (GWA) and linkage analysis exploring the genetic basis of these endophenotypes in a community-based sample...
  5. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
    ..This locus contains the brain-expressed GTP-binding RAS-like 2 gene (DIRAS2) thought to regulate neurogenesis...

Research Grants1