Genomes and Genes
Gene Symbol: desmin
Alias: CSM1, CSM2, LGMD2R, desmin, intermediate filament protein, mutant desmin p.K241E
Publications296 found, 100 shown here
- An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cellsM Mericskay
Laboratoire de Biologie Moléculaire de la Différenciation, Universite Denis Diderot Paris 7, 2, place Jussieu, Paris, 75005, France
Dev Biol 226:192-208. 2000The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells...
- The enlarging spectrum of desminopathies: new morphological findings, eastward geographic spread, novel exon 3 desmin mutationAlexandra Vrabie
Department of Neuropathology, Johannes Gutenberg University Medical Center, Langenbeckstrasse 1, 55101 Mainz, Germany
Acta Neuropathol 109:411-7. 2005..of the older brother revealed granulofilamentous material and plaques containing numerous proteins, foremost desmin, as did cardiac biopsy tissue...
- Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elementsWei Jiang
College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, PR China
BMC Syst Biol 2:72. 2008..The aim of this study was thus to develop such a novel networking approach based on the relevance concept, which is ideal to reveal integrative effects of multiple genes in the underlying genetic circuit for complex diseases...
- High level desmin expression depends on a muscle-specific enhancerZ L Li
Laboratoire de Biologie Moléculaire de la Différentiation Cellulaire, Universite Paris, France
J Biol Chem 266:6562-70. 1991Expression of the desmin gene is increased several-fold during myogenesis. To identify the DNA sequences involved in this regulation, a 16-kilobase fragment containing a 4...
- Assignment of human desmin gene to band 2q35 by nonradioactive in situ hybridizationE Viegas-Pequignot
URA 620 CNRS, Structure et Mutagenèse Chromosomiques, Institut Curie, Paris, France
Hum Genet 83:33-6. 1989A 3-kb DNA fragment, inserted in Bluescribe vector, was used to localize the desmin gene by in situ hybridization on human metaphase chromosomes. The probe was labelled by Bio-11-dUTP and detected by immunofluorescence...
- A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formationG Sjoberg
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Hum Mol Genet 8:2191-8. 1999In some myopathies of distal onset, the intermediate filament desmin is abnormally accumulated in skeletal and cardiac muscle...
- Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutationsMarinos C Dalakas
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 4B37, 10 Central Drive, MSC 1361, Bethesda, MD 20892, USA
Neuromuscul Disord 13:252-8. 2003b>Desmin myopathy is a familial or sporadic disorder characterized by the presence of desmin mutations that cause skeletal muscle weakness associated with cardiac conduction block, arrhythmia and heart failure...
- Small deletions disturb desmin architecture leading to breakdown of muscle cells and development of skeletal or cardioskeletal myopathyAnna Kaminska
Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
Hum Genet 114:306-13. 2004b>Desmin ( DES) mutations have been recognized as a cause of desmin-related myopathy (OMIM 601419), or desminopathy, a disease characterized by progressive limb muscle weakness and accumulation of desmin-reactive granular aggregates in the ..
- A myopathy-linked desmin mutation perturbs striated muscle actin filament architectureGloria M Conover
Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
Mol Biol Cell 20:834-45. 2009b>Desmin interacts with nebulin establishing a direct link between the intermediate filament network and sarcomeres at the Z-discs...
- Disease mutations in the "head" domain of the extra-sarcomeric protein desmin distinctly alter its assembly and network-forming propertiesSarika Sharma
Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
J Mol Med (Berl) 87:1207-19. 2009The intermediate filament protein desmin generates an extra-sarcomeric network in myocytes. Mutations in the desmin gene cause myofibrillar myopathy characterized by desmin-positive aggregates and myofibrillar dissolution...
- Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES geneJ Peter van Tintelen
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Heart Rhythm 6:1574-83. 2009..Mutations in the gene encoding desmin (DES), a major intermediate filament protein, can underlie this phenotype.
- Mutations in desmin's carboxy-terminal "tail" domain severely modify filament and network mechanicsHarald Bär
Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
J Mol Biol 397:1188-98. 2010Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies...
- Desmin mutations as a cause of right ventricular heart failure affect the intercalated disksEllen Otten
Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands
Heart Rhythm 7:1058-64. 2010Mutations in the gene encoding desmin (DES), an intermediate filament protein, underlie a heterogeneous phenotype, which is referred to as desmin-related myopathy (DRM)...
- Desmin-related myopathyK Y VAN Spaendonck-Zwarts
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Clin Genet 80:354-66. 2011b>Desmin-related myopathy (DRM) is an autosomally inherited skeletal and cardiac myopathy, mainly caused by dominant mutations in the desmin gene (DES)...
- De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathyBaerbel Klauke
Herz and Diabeteszentrum NRW, Klinik f Thorax und Kardiovaskularchirurgie, Erich und Hanna Klessmann Institutfür Kardiovaskulaere Forschung und Entwicklung Klinik fuer angeborene Herzfehler, Georgstrasse 11, Bad Oeynhausen, Germany
Hum Mol Genet 19:4595-607. 2010..In 43% of the cohort, we found disease-associated sequence variants. In addition, we screened for desmin mutations and found a novel desmin-mutation p...
- Desmin mutations in the terminal consensus motif prevent synemin-desmin heteropolymer filament assemblyOussama Chourbagi
University Paris Diderot Paris 7 CNRS EAC4413, Unit of Functional and Adaptive Biology, Laboratory of Stress and Pathologies of the Cytoskeleton, F 75013, Paris, France
Exp Cell Res 317:886-97. 2011..Synemin is a desmin-associated type VI intermediate filament protein. Neither its impact on desmin network nor how it integrates into desmin filament is yet elucidated...
- Desmin-related cardiomyopathy: an unfolding storyPatrick M McLendon
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Heart Circ Physiol 301:H1220-8. 2011The intermediate filament protein desmin is an integral component of the cardiomyocyte and serves to maintain the overall structure and cytoskeletal organization within striated muscle cells...
- Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutantsAndreas Brodehl
E and H Klessmann Institute for Cardiovascular Research and Development, Ruhr University Bochum, 32545 Bad Oeynhausen, Germany
J Biol Chem 287:16047-57. 2012Mutations in the DES gene coding for the intermediate filament protein desmin may cause skeletal and cardiac myopathies, which are frequently characterized by cytoplasmic aggregates of desmin and associated proteins at the cellular level...
- Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and developmentZ L Li
Laboratoire de Biologie Moléculaire de la Différentiation Cellulaire, Universite Paris, France
Gene 78:243-54. 1989A recombinant clone encoding for the human desmin gene (des) has been isolated and characterized and its complete nucleotide sequence has been determined. The 8.4-kb gene has nine exons separated by introns ranging in size from 0.1-2.2 kb...
- Human desmin gene: cDNA sequence, regional localization and exclusion of the locus in a familial desmin-related myopathyP Vicart
Universite Paris VII, Paris, France
Hum Genet 98:422-9. 1996b>Desmin is a muscle-specific intermediate filament that is encoded by a gene assigned to human chromosome 2q35. Desmin-related myopathies are inherited disorders characterized by an intrasarcoplasmic accumulation of desmin...
- A dysfunctional desmin mutation in a patient with severe generalized myopathyA M Munoz-Marmol
Fundación Echevarne, 08037 Barcelona, Spain
Proc Natl Acad Sci U S A 95:11312-7. 1998Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile and degenerate upon repeated contractions...
- Molecular dissection of the interaction of desmin with the C-terminal region of nebulinMarie Louise Bang
Department of Anesthesiology and Intensive Operative Care, Universitatsklinikum Mannheim, Mannheim, Germany
J Struct Biol 137:119-27. 2002..This identified that the nebulin modules M160 to M170 interact with desmin. In desmin, deletion series experiments assigned a 19-kDa central coiled-coil domain as the nebulin-binding site...
- Desmin A213V substitution represents a rare polymorphism but not a mutation and is more prevalent in patients with heart dilation of various originsA Kostareva
Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
Acta Myol 30:42-5. 2011Several desmin mutations have been described in patients with cardiomyopathies and distal myopathies...
- Biomechanical characterization of a desminopathy in primary human myoblastsNavid Bonakdar
Department of Physics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Biochem Biophys Res Commun 419:703-7. 2012Heterozygous mutations of the human desmin gene on chromosome 2q35 cause hereditary and sporadic myopathies and cardiomyopathies...
- Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutationCarola Hedberg
Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Eur J Hum Genet 20:984-5. 2012..A heterozygous C-to-T transition, c.1255C>T, p.Pro419Ser in the desmin gene on chromosome 2q35, was identified. Previous studies had demonstrated linkage to chromosome 10q22...
- A novel heterozygous deletion-insertion mutation in the desmin gene causes complete atrioventricular block and mild myopathyLingling Cao
Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang, PR China
Clin Neuropathol 32:9-15. 2013Defects in the desmin gene have been identified in patients with cardiac and skeletal myopathy characterized by sarcoplasmic accumulation of desmin-positive deposits and electron dense granulofilamentous aggregates...
- Missense mutations in desmin associated with familial cardiac and skeletal myopathyL G Goldfarb
Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
Nat Genet 19:402-3. 1998b>Desmin-related myopathy (OMIM 601419) is a familial disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-..
- Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filamentsJoy G Ghosh
Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, United States
Int J Biochem Cell Biol 39:1804-15. 2007..in human alphaB crystallin that selectively interacted with native or partially unfolded filament proteins desmin, glial-fibrillary acidic protein, and actin...
- Desmin mutations in a St. Petersburg cohort of cardiomyopathiesA Kostareva
Department of Woman and Child Health, and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
Acta Myol 25:109-15. 2006Several desmin mutations have been described over the past few years in patients with dilated and restrictive cardiomyopathy, often in association with distal myopathy...
- Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathyJohannes Levin
Klinikum Grosshadern, Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
J Neuropathol Exp Neurol 69:415-24. 2010Mutations in the intermediate filament protein desmin cause a distinct class of myofibrillar myopathies that are characterized by deposition of aggregated desmin...
- The human desmin locus: gene organization and LCR-mediated transcriptional controlJennifer L Y Tam
Nuclear Biology Group, Department of Medical and Molecular Genetics, King s College London School of Medicine, King s College London Guy s Campus, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Genomics 87:733-46. 2006..We report the first characterization of a muscle-cell-specific LCR, which is linked to the human desmin gene (DES)...
- Prevalence of desmin mutations in dilated cardiomyopathyMatthew R G Taylor
University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
Circulation 115:1244-51. 2007b>Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene...
- Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosinR L Shoeman
Max Planck Institut für Zellbiologie, Ladenburg, Federal Republic of Germany
Am J Pathol 142:221-30. 1993..myofibrils treated in vitro with human immunodeficiency virus type 1 protease showed that myosin heavy chain, desmin, tropomyosin, and a fraction of the actin were all cleaved...
- Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filamentsH Inada
Division of Biochemistry, Aichi Cancer Center Research Institute, 1 1 Chikusa ku, Nagoya, Aichi 464 8681, Japan
J Biol Chem 274:34932-9. 1999..The balance between intermediate filament protein phosphorylation by Rho kinase and dephosphorylation by type 1 protein phosphatase may affect the ..
- Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseasesMontse Olive
Institut de Neuropatologia, Ciutat Sanitaria i Universitaria de Bellvitge, C Feixa Llarga s n masculine, 08907 Hospitalet de Llobregat, Spain
Acta Neuropathol 106:1-7. 2003..skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin...
- Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the ratA Ahluwalia
Department of Biochemical Pharmacology, William Harvey Research Institute, St Bartholomew s Medical College, London
Br J Pharmacol 108:544-8. 1993....
- Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascadeG Mazzocchi
Department of Human Anatomy and Physiology, University of Padua, Italy
Horm Metab Res 32:265-8. 2000..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH...
- Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated tracheaA da Silva
Laboratoire de Neuroimmunopharmacologie, INSERM U405, , , Illkirch, France
Br J Pharmacol 114:103-8. 1995..The stimulation of B2-bradykinin receptors induces the activation of the cyclo-oxygenase pathway, leading either to contraction or relaxation depending on the tone of the trachea...
- Repellent activity of estrogenic compounds toward zoospores of the phytopathogenic fungus Aphanomyces cochlioidesM T Islam
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
Z Naturforsch C 56:253-61. 2001..So far, this will be the first report of repellent activity of estrogenic compounds toward trivial fungal zoospores...
- Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticumF J Legat
Department of Experimental and Clinical Pharmacology, University of Graz, Austria
Br J Pharmacol 112:453-60. 1994..The present results might provide an experimental basis for clinical investigations of the effects of icatibant in infectious diseases where the release of collagenases from bacteria causes rapid spreading of inflammation...
- A randomized trial of chemotherapy with or without estrogenic recruitment in locally advanced breast cancer. North-West Oncology Group (GONO) Study, ItalyE Baldini
U.O. Oncologia Medica, Pisa, Italy
Tumori 83:829-33. 1997..Further research is needed to investigate different schedules of chemotherapy and hormones, or to test the possibility of combining various mitogens...
- The effect of in vivo oestrogen pretreatment on the contractile response of rat isolated detrusor muscleR A Elliott
Department of Medicine for the Elderly, Leicester General Hospital
Br J Pharmacol 107:766-70. 1992..8. These results suggest that oestradiol pretreatment had a modulating effect on cholinergic responses.The addition of oestrogen to the tissue environment enhances this inhibitory effect...
- Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin geneM C Dalakas
Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1382, USA
N Engl J Med 342:770-80. 2000Myofibrillar myopathies, often referred to as desmin-related myopathies, are a heterogeneous group of inherited or sporadic distal-onset skeletal myopathies associated with cardiomyopathy...
- Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratinsYoshiaki Hirako
Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya, Japan
Cell Tissue Res 313:195-207. 2003..a monoclonal antibody, we have detected a high molecular weight muscle protein, co-localized and co-isolating with desmin. Searching a human cDNA database with partial amino acid sequences of the protein, we found a cDNA clone encoding ..
- A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localizationManolis Mavroidis
Cell Biology Division, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece
FASEB J 22:3318-27. 2008A missense mutation (Ile 451 to Met) at the tail domain of the muscle-specific intermediate filament protein desmin has been suggested to be a genetic cause of dilated cardiomyopathy...
- Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferensJ Maas
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Brazil
Br J Pharmacol 114:1471-7. 1995....
- UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetumK Stich
TU Wien, , Technische Mikroskopie und Organische Rohstofflehre, Vienna, Austria
Z Naturforsch C 52:153-8. 1997..1 mu kat/kg protein) as substrate, indicating that hydroxylation of quercetin in 8-position to gossypetin precedes 7-O-glucosylation...
- Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogeninH Li
Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
J Cell Biol 124:827-41. 1994The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic markers whose functional role during myogenic commitment and differentiation is unknown...
- Molecular characteristics and interactions of the intermediate filament protein synemin. Interactions with alpha-actinin may anchor synemin-containing heterofilamentsR M Bellin
Muscle Biology Group, Department of Biochemistry, Iowa State University, Ames, Iowa 50011 3260, USA
J Biol Chem 274:29493-9. 1999..filament (IF)-associated protein because of its colocalization and copurification with the IF proteins desmin and vimentin in muscle cells...
- Desmin: molecular interactions and putative functions of the muscle intermediate filament proteinM L Costa
Laboratório de Diferenciação Muscular e Citoesqueleto, Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
Braz J Med Biol Res 37:1819-30. 2004b>Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells...
- Desmin: a major intermediate filament protein essential for the structural integrity and function of muscleDenise Paulin
Biologie Moleculaire de la Differenciation, Universite Paris, 75251 Paris, France
Exp Cell Res 301:1-7. 2004b>Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles...
- Lower active force generation and improved fatigue resistance in skeletal muscle from desmin deficient miceJ Balogh
Department of Physiological Sciences, Lund University, BMC F11, Tornavagen 10, SE 221 84, Lund, Sweden
J Muscle Res Cell Motil 24:453-9. 2003The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+)...
- Assembly properties of two CNBr fragments of avian desmin that correspond to the headpiece domain and helix 1BT Saeed
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267 0521
Biochem Biophys Res Commun 165:1059-66. 1989To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions...
- Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failurePanagiota Panagopoulou
Cell Biology Division, Center of Basic Research, and 2Cardiovascular Research Division, Center of Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece
J Cell Biol 181:761-75. 2008We explored the involvement of the muscle-specific intermediate filament protein desmin in the model of tumor necrosis factor alpha (TNF-alpha)-induced cardiomyopathy...
- Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsinK N Koushik
Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198-6025, USA
Pharm Dev Technol 6:595-606. 2001..This inclusion, providing steric hindrance, may be one of the mechanisms by which HPbetaCD reduces enzymatic hydrolysis of deslorelin...
- Life-long effect of a single neonatal treatment with estradiol or progesterone on rat uterine estrogen receptor binding capacityG Csaba
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary
Horm Metab Res 24:167-71. 1992....
- [Role of B1 receptors in the endothelial protective effect of ischaemic preconditioning]J F Bouchard
, , , Canada
Arch Mal Coeur Vaiss 91:941-5. 1998..B2 receptors do not play any role in that protection...
- Inhibition of the angiotensin converting enzyme by perindoprilat and release of nitric oxideB Desta
Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Hypertens 8:1S-6S. 1995..In addition, the response to perindoprilat may be due to factors other than just protection of bound bradykinin from degradation...
- Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitroA Dray
Sandoz Institute for Medical Research, London
Br J Pharmacol 107:1129-34. 1992..The effects of bradykinin were mediated by a B2 receptor...
- Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 productionJ P Galizzi
Cerep, Celle l evescault, France
Br J Pharmacol 113:389-94. 1994..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway...
- Atriopeptin regulation and renal function in conscious spontaneously hypertensive ratsJ P Koepke
Searle Research and Development, Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110
Am J Hypertens 3:622-7. 1990..Compared to vehicle control rats, plasma APir was increased during coadministration of SC-46542 and thiorphan in both SHR (998 +/- 76 v 5.10 +/- 116 pg/mL) and WKY (775 +/- 36 v 414 +/- 36 pg/mL).(ABSTRACT TRUNCATED AT 250 WORDS)..
- Mediation by B1 and B2 receptors of vasodepressor responses to intravenously administered kinins in anaesthetized dogsN Nakhostine
Department of Physiology, Faculty of Medicine, , , Canada
Br J Pharmacol 110:71-6. 1993..These findings provide pharmacological evidence for the existence of functionally active B1 receptors in canine cardiovascular homeostasis...
- The effect of oxidation or alkylation on the separation of wool keratin proteins by two-dimensional gel electrophoresisJeffrey E Plowman
Wool Research Organisation of New Zealand, Christchurch, New Zealand
Proteomics 3:942-50. 2003..Peroxide treatment was found to have only a minor effect on the 2-DE separation of the intermediate filament protein (IFP) class...
- [Belgian law on the RÃ©gime de l'alcool of 1919: from the individual measures to social well-being]R Campos
Departamento de Historia de la Ciencia, , CSIC
Cuad Complut Hist Med Cienc 2:275-94. 1993....
- [Mediastinitis after sternotomy. Mortality and hospital length of stay. Groupe parisien dÃ©tude des sternotomies]J C Lucet
, , Paris
Arch Mal Coeur Vaiss 90:471-5. 1997..The authors conclude that deep wound infection after sternotomy is responsible for almost doubling the duration of hospital stay. The economic consequences alone justify active research into the prevention of this complication...
- Structural heterogeneity of the Fe(2+)-N epsilon (HisF8) bond in various hemoglobin and myoglobin derivatives probed by the Raman-active iron histidine stretching modeH Gilch
Institute of Experimental Physics, University of Bremen, Germany
Biophys J 65:1470-85. 1993..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...
- Polymorphous ventricular tachycardia following cardiopulmonary bypassL D Thompson
Cardiothoracic Surgery Service, Valley Children Hospital, Fresno, California 93726, USA
J Natl Med Assoc 88:49-51. 1996..This case shows the effectiveness of intravenous magnesium in controlling Torsade des pointes in postoperative coronary bypass patients...
- Pharmacological characterization of bradykinin receptors in canine cultured tracheal smooth muscle cellsC M Yang
Department of Pharmacology, Chang Gung College of Medicine and Technology, Tao Yuan, Taiwan
Br J Pharmacol 114:67-72. 1995..7 It is concluded that the pharmacological characteristics of the bradykinin receptors in canine cultured TSMCs are primarily of the B2 receptor subtype...
- Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic proteinJ E Ralton
Department of Biochemistry, The University, Dundee, UK
J Cell Sci 107:1935-48. 1994..GFAP is the only type III intermediate filament protein in which this motif is not readily identified...
- [Evidence for a glomerular receptor for bradykinin in rats. Effect of sodium intake on density and affinity of the receptor]J L Bascands
INSERM U 133, , Toulouse
Arch Mal Coeur Vaiss 82:1219-22. 1989..45 +/- 1.3 and 13.25 +/- 1.17 fmol/mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)..
- [The MusÃ©e du service de santÃ© des armeÃ©s in Val-de-GrÃ¢ce]J J Ferrandis
Hist Sci Med 33:183-90. 1999..The visitor may also discover the marvelous mortars and pharmacy pots collection of the doctors Debat...
- The role of bradykinin B1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritisS C Cruwys
Inflammation Group, London Hospital Medical College
Br J Pharmacol 113:940-4. 1994..The data presented in this study suggest an evolving role for B1 receptors in the mediation of plasma extravasation in inflamed joint tissues. A role for BK antagonists in the treatment of arthritis is also suggested...
- Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 miceA Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 27:325-33. 1999..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...
- Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505F Pons
Department of Applied Pharmacology, National Heart and Lung Institute, London
Br J Pharmacol 109:234-42. 1993..However, they question the role of PAF receptors on platelets in this model. The results also indicate that PAF may be involved in platelet accumulation induced by zymosan in rabbit skin...
- Connexin 43 expression in glial cells of developing rhombomeres of Xenopus laevisBharti Katbamna
Department of Speech Pathology and Audiology, Western Michigan University, Kalamazoo, MI 49008 5355, USA
Int J Dev Neurosci 22:47-55. 2004..Xenopus rhombomeres and then tracked expression of connexin 43 and glial fibrillary acidic protein, an intermediate filament protein known to mark glia during rhombomeric development...
- Regulation of vimentin intermediate filaments in endothelial cells by hypoxiaTiegang Liu
Pulmonary and Critical Care Division, Department of Medicine Tupper Research Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Am J Physiol Cell Physiol 299:C363-73. 2010..We now show that vimentin, a major intermediate filament protein in endothelial cells, is regulated by hypoxia...
- The IAEA/WHO TL dosimetry service for radiotherapy centres 1969-87H Svensson
International Atomic Energy Agency, Vienna, Austria
Acta Oncol 29:461-7. 1990..7%. About 5% of the centres had deviations larger than 30%, at least on one occasion. It is shown that the accuracy in dosimetry improves considerably for those departments participating more than once in the TL dosimetry service...
- Mechanism of bradykinin-induced plasma extravasation in the rat knee jointH Cambridge
Pharmacology Group, King s College London
Br J Pharmacol 115:641-7. 1995....
- Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cellsR Plevin
Department of Biochemistry, University of Glasgow
Br J Pharmacol 107:109-15. 1992....
- Lens membrane fraction associated intermediate filaments of different aged ratsCharles Ricky Fleschner
Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
Curr Eye Res 24:296-304. 2002..To describe the intermediate filament proteins vimentin, filensin and phakinin associated with different fractions isolated from neonatal, 10 day old and 20 day old rat lenses...
- Lysosomal enzymes in pregnant and steroid treated ratsA Isaksson
Department of Clinical Chemistry, University Hospital, Lund, Sweden
Horm Metab Res 20:274-7. 1988..No significant changes were observed for the other two enzymes. Thus, steroid treatment did not fully reproduce the enzyme changes seen in pregnancy, which may indicate that these are not solely due to a hormone effect...
- A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament proteinY Chan
Howard Hughes Medical Institute, University of Chicago, Illinois 60637
Genes Dev 8:2574-87. 1994....
- Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo in LocustaM J Lee
Department of Biology, Birkbeck College, University of London, London, UK
J Comp Physiol B 166:61-7. 1996..The different responses exploited in these assays may be exerted through different receptor populations...
- Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouseC R Correa
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis SC, Brazil
Br J Pharmacol 110:193-8. 1993..In addition, the current results also demonstrate that the inflammatory oedema associated with the later phase of formalin-induced pain seems to be mediated by endogenous BK, via activation of B2 receptors...
- Vasoconstrictor effects of various neuropeptide Y analogues on the rat tail artery in the presence of phenylephrineM Tschopl
Laboratoire de Pharmacologie Cellulaire et Moleculaire, C N R S URA 600, Universite Louis Pasteur Strasbourg, Illkirch, France
Br J Pharmacol 110:1098-104. 1993..The effects of [des-Ser3,Lys4]D-Cys2-NPY indicate that the Y1-receptor may possess an allosteric binding site...
- Expression and distribution of cytokeratins and vimentin in rat larynx and trachea following irradiationS Bartel-Friedrich
Department of Otorhinolaryngology, Phoniatrics and Pedaudiology Section, University Hospital, Martin Luther University Halle Wittenberg, Germany
Anticancer Res 27:2059-69. 2007..However, reports on radiogenic intermediate filament protein alterations in laryngeal-tracheal tissues are very rare...
- Hemodynamic effects of atrial natriuretic factor clearance receptor occupancy in conscious sheepD G Parkes
Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Australia
Am J Hypertens 3:829-32. 1990..These studies support the concept of the metabolism of ANF via clearance receptors, suggesting that long-term hemodynamic actions of endogenous ANF may be achieved via prolonged blockade of these clearance receptors...
- [Serodiagnosis of toxoplasmosis: a comparative multicenter study of a standard scale through various actual tests and expression of the results in international units. Groupe de travail toxoplasmose du ContrÃ´le national de qualitÃ© en parasotologie. SyndJ C Petithory
Service de Biologie, , Centre Hospitalier, Gonesse, France
Bull World Health Organ 74:291-8. 1996..It is therefore essential that the conditions and limits for a positive reaction be carefully defined in each case, especially for commercially available kits...
- Differential expressions of protein kinase C isozymes during proliferation and differentiation of human skeletal muscle cells in vitroJ Boczan
Department of Physiology and Cell Physiology, University Medical School of Debrecen, Hungary
Acta Neuropathol 99:96-104. 2000..The expressions of desmin, used as a muscle-specific intermediate filament protein marker of differentiation, and of different PKC isozymes were detected by single and double ..
- Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)A Yoshida
Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 28:237-45. 2000....
- Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiationA Sandilands
Department of Biochemistry, The University, Dundee, UK
J Cell Sci 108:1397-406. 1995The cells of the eye lens contain the type III intermediate filament protein vimentin, as well as two other intermediate filament proteins, CP49 and filensin. These two proteins appear to be unique to the differentiated lens fibre cell...
- [The war victim]P Hugeux
, , Clamart
Bull Acad Natl Med 178:1357-63; discussion 1363-4. 1994..These joint actions, added to the ones of very influential autonomous associations, contribute to give handicapped war victims an honourable citizenship...
- [The Hypertension Cochrane Review Group. Presentation and user's guide]F Gueyffier
, Service de Pharmacologie Clinique, Lyon
Arch Mal Coeur Vaiss 90:1159-63. 1997..The second edition in 1996 of the Cochrane Library included 114 systematic reviews and 131 protocols, being the only media with similar objectives...
- Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitroD A Cabrini
Universidade Federal de Santa Catarina, , Brazil
Br J Pharmacol 114:1549-56. 1995....
- Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cellsC M Yang
Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
Br J Pharmacol 111:21-8. 1994..The transduction mechanism of BK coupled to PI hydrolysis is sensitive to feedback regulation by PKC...
- Type II intermediate-filament proteins from wool. The amino acid sequence of component 5 and comparison with component 7cL G Sparrow
C S I R O Division of Wool Technology, Parkville, Vic, Australia
Biochem J 282:291-7. 1992....
- Simultaneous expression of keratin and glial fibrillary acidic protein by the same cells in epiretinal membranesS A Vinores
Department of Ophthalmology and Neuroscience, Johns Hopkins University Hospital, Baltimore, Maryland
Invest Ophthalmol Vis Sci 33:3361-6. 1992..Examination of intermediate filament protein content by immunocytochemical analysis can help to identify some cells with altered ultrastructure but ..
- A new marker for cup cells in the rabbit small intestine: expression of vimentin intermediate filament proteinY Fujimura
Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
Med Electron Microsc 34:223-9. 2001..In rabbit small intestine, vimentin is useful for the detection of cup cells, as well as M cells, and may facilitate the investigation of these little understood cells...
- The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413Olaf Bossinger
Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, D 40225 Duesseldorf, Germany
Dev Biol 268:448-56. 2004..We demonstrate that: (i) the widely used monoclonal antibody MH33 reacts (only) with the gut-specific intermediate filament protein encoded by the ifb-2 gene; (ii) IFB-2 protein accumulates near the gut lumen beginning at the lima ..
- In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IFLisa Gu
Molecular and Cell Biology Graduate Program, University of Maryland Biotechnology Institute, Baltimore 21201, USA
Exp Cell Res 298:249-61. 2004..either mutated or swapped between a cytoplasmic (mouse neurofilament-light (NF-L) subunit) and nuclear intermediate filament protein (human lamin A)...
- Novel cell lines derived from adult human ventricular cardiomyocytesMercy M Davidson
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
J Mol Cell Cardiol 39:133-47. 2005..heavy chain, alpha-cardiac actin, troponin I, desmoplakin, alpha actinin, the muscle-specific intermediate filament protein, desmin, the cardiomyocyte-specific peptide hormones, BNP, the L-type calcium channel alpha1C subunit ..
- INTERFERON EFFECTS ON INTERMEDIATE FILAMENTS IN TUMOR CEDIANNE BUCKMAN; Fiscal Year: 1992..not only a better understanding of the relationship between the actions of the interferons and intermediate filament protein and gene expression but also contributing information towards a broader biological understanding of ..
- Discovery of Novel Autoantigens in Patients with Inclusion Body MyositisKEVIN C O'CONNOR; Fiscal Year: 2013..We discovered that a muscle intermediate filament protein was recognized by IBM tissue-derived immunoglobulin...
- Alexander Disease: Cellular and Molecular MechanismsAlbee Messing; Fiscal Year: 2012..neurodegenerative disease that results from heterozygous mutations in the gene encoding the type III intermediate filament protein GFAP...
- Intermediate filament cytoskeleton and cell shape in Caulobacter crescentusChristine Jacobs Wagner; Fiscal Year: 2009..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...
- MOLECULAR REGULATION OF INTERMEDIATE FILAMENT STRUCTURERobert Evans; Fiscal Year: 1991..The proposed experiments will use the intermediate filament protein vimentin as a model for phosphorylation regulated filament organization...
- ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLEThomas Lincoln; Fiscal Year: 1999..One protein that may be involved in localizing cGMP kinase to substrates is the cytoskeletal intermediate filament protein vimentin...
- Adam I Marcus; Fiscal Year: 2015..Numerous reports show that the intermediate filament protein vimentin is overexpressed in invasive human tumors but is nearly undetectable in non- invasive, ..
- Role of Vimentin, sPLA2 and LysoPC in Autoimmune DiseaseSUZANNE BARBOUR; Fiscal Year: 2005..The "receptor" for this pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed when cells undergo apoptosis...
- EPITHELIO MESENCHYMAL TRANSITION IN BREAST CANCERErik Thompson; Fiscal Year: 2001..Expression of the mesenchymal cell intermediate filament protein vimentin (VIM) has been used traditionally as a marker of the EMT...
- K P CONNIE TAM; Fiscal Year: 2016..of antimicrobial peptides (KDAMPs), which are glycine-rich C-terminal fragments of keratin 6A, a major intermediate filament protein found in the cytoskeleton of a wide range of epithelial cells...
- GROWTH FACTOR CONTROL OF UTERINE CELL FUNCTION IN VITRODaniel Carson; Fiscal Year: 1992..These responses include altered patterns of glycoprotein and ECM expression, intermediate filament protein (desmin) expression and prostaglandin (PG) secretion...
- Skeletal Muscle Injury: Mechanism Prevention & TreatmentRichard Lieber; Fiscal Year: 2007..3) to measure the relative strengthening ability of normal muscles compared to muscles devoid of the intermediate filament protein desmin...
- RODNEY J ROTHSTEIN; Fiscal Year: 2014..We will further characterize the role of the Shu suppressor complex (Shu1/Shu2/Psy3/Csm2) in en-or-free repair...
- WILLIAM GAINES; Fiscal Year: 2014..The goal of this project is to elucidate the functional role of the Shu1-Shu2-Csm2-Psy3 (Shu) complex of S. cerevisiae...
- Primaquine-binding proteins identified in PneumocystisSHERRY QUEENER; Fiscal Year: 2006..Preliminary identification of one of these proteins suggests it is an intermediate filament protein, which may relate to the profound cytoplasmic disruption produced in Pneumocystis by 8-aminoquinolines...
- SWITCHING IN CANDIDA ALBICANSDavid Soll; Fiscal Year: 1990..budding pattern, zones of cell wall expansion, chitin deposition, and dynamics of actin, tubulin and intermediate filament protein localization which may accompany switching, 4) to complete the characterization of high frequency ..
- PTP1C INCREASES IN THE DEAFFERENTED AUDITORY BRAINSTEMDIANA LURIE; Fiscal Year: 2001..morphological changes; including proliferation, process extension, and increased levels of the glial intermediate filament protein, GFAP...
- INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONSRobert Goldman; Fiscal Year: 2008..The latter include the formation of Mallory bodies in alcoholic liver disease and Lewy bodies in Parkinson's disease. ..
- FUNCTION OF GFAP IN ASTROCYTE DEVELOPMENT AND DISEASEAlbee Messing; Fiscal Year: 2002..In specific aim 3, he will test the hypothesis that formation of Rosenthal fibers in astrocytes is associated with fundamental physiological changes in astrocytes and in neuron-glial interactions. ..
- Lens plasma membrane-cytokeleton in selenite cataractCHARLES FLESCHNER; Fiscal Year: 2003..Also, these studies will describe changes in the cytoskeletal network which are associated with the formation of cataracts. It is anticipated this information will be useful in the understanding of human senile cataract. ..
- Nanospheres as Vehicles for Treatment of NeuroblastomaThomas Shea; Fiscal Year: 2004..Resulting data will indicate whether or not nanospheres represent useful delivery agents for cancer therapy. ..
- LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTIONRobert D Goldman; Fiscal Year: 2010..These collective studies will provide important insights into how hLA mutations cause the defects seen in progeria. ..
- Diabetes Mellitus and Astrocyte Regulation of GlutamateElaine Coleman; Fiscal Year: 2005..In summary, this application targets the role of altered astrocyte activity and glutamate uptake in diabetes-induced CNS disorders. ..
- Intermediate Filaments 2008 Gordon Research ConferenceThomas Shea; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Endothelial Cell Migration and Retinal AngiogenesisRobert Fischer; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTSAnna Lysakowski; Fiscal Year: 2008..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
- Is S-adenosyl Methionine a Nutrition: Genetic Link in AD?Thomas Shea; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Improving Waisman Center Animal Care FacilityAlbee Messing; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Import of Adenovirus DNA into the nucleusLarry Gerace; Fiscal Year: 2007..Finally, it could provide the basis for developing efficient means for nonviral gene transfer, which would be useful for gene therapy and functional studies of cells. ..
- Familial Dilated Cardiomyopathy:Genetic CharacterizationMatthew Taylor; Fiscal Year: 2006..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..
- Is a therapy for Alexander disease already FDA-approved?Albee Messing; Fiscal Year: 2006..By restricting the focus to the FDA-approved list, successful identification of GFAP-suppressing drugs could offer immediate therapeutic benefit to Alexander disease patients. ..
- INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONSRobert D Goldman; Fiscal Year: 2010....
- Screen for Small Molecule Inhibitors of Nuclear Protein ImportLarry Gerace; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISMS OF NUCLEAR IMPORTLarry Gerace; Fiscal Year: 2006..Thus, understanding basic nuclear transport mechanisms can provide a framework for developing new therapeutic approaches relevant to viral pathogenesis, cancer and immunity and other processes. ..