desmin

Summary

Gene Symbol: desmin
Description: desmin
Alias: CSM1, CSM2, LGMD2R, desmin, intermediate filament protein, mutant desmin p.K241E
Species: human

Top Publications

  1. ncbi An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells
    M Mericskay
    Laboratoire de Biologie Moléculaire de la Différenciation, Universite Denis Diderot Paris 7, 2, place Jussieu, Paris, 75005, France
    Dev Biol 226:192-208. 2000
  2. ncbi The enlarging spectrum of desminopathies: new morphological findings, eastward geographic spread, novel exon 3 desmin mutation
    Alexandra Vrabie
    Department of Neuropathology, Johannes Gutenberg University Medical Center, Langenbeckstrasse 1, 55101 Mainz, Germany
    Acta Neuropathol 109:411-7. 2005
  3. pmc Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements
    Wei Jiang
    College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, PR China
    BMC Syst Biol 2:72. 2008
  4. ncbi High level desmin expression depends on a muscle-specific enhancer
    Z L Li
    Laboratoire de Biologie Moléculaire de la Différentiation Cellulaire, Universite Paris, France
    J Biol Chem 266:6562-70. 1991
  5. ncbi Assignment of human desmin gene to band 2q35 by nonradioactive in situ hybridization
    E Viegas-Pequignot
    URA 620 CNRS, Structure et Mutagenèse Chromosomiques, Institut Curie, Paris, France
    Hum Genet 83:33-6. 1989
  6. ncbi A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formation
    G Sjoberg
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Hum Mol Genet 8:2191-8. 1999
  7. ncbi Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutations
    Marinos C Dalakas
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 4B37, 10 Central Drive, MSC 1361, Bethesda, MD 20892, USA
    Neuromuscul Disord 13:252-8. 2003
  8. ncbi Small deletions disturb desmin architecture leading to breakdown of muscle cells and development of skeletal or cardioskeletal myopathy
    Anna Kaminska
    Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Hum Genet 114:306-13. 2004
  9. pmc A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture
    Gloria M Conover
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Mol Biol Cell 20:834-45. 2009
  10. doi Disease mutations in the "head" domain of the extra-sarcomeric protein desmin distinctly alter its assembly and network-forming properties
    Sarika Sharma
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Mol Med (Berl) 87:1207-19. 2009

Research Grants

  1. INTERFERON EFFECTS ON INTERMEDIATE FILAMENTS IN TUMOR CE
    DIANNE BUCKMAN; Fiscal Year: 1992
  2. Discovery of Novel Autoantigens in Patients with Inclusion Body Myositis
    KEVIN C O'CONNOR; Fiscal Year: 2013
  3. Alexander Disease: Cellular and Molecular Mechanisms
    Albee Messing; Fiscal Year: 2012
  4. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2009
  5. MOLECULAR REGULATION OF INTERMEDIATE FILAMENT STRUCTURE
    Robert Evans; Fiscal Year: 1991
  6. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
  7. Adam I Marcus; Fiscal Year: 2015
  8. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
  9. EPITHELIO MESENCHYMAL TRANSITION IN BREAST CANCER
    Erik Thompson; Fiscal Year: 2001
  10. K P CONNIE TAM; Fiscal Year: 2016

Detail Information

Publications296 found, 100 shown here

  1. ncbi An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells
    M Mericskay
    Laboratoire de Biologie Moléculaire de la Différenciation, Universite Denis Diderot Paris 7, 2, place Jussieu, Paris, 75005, France
    Dev Biol 226:192-208. 2000
    The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells...
  2. ncbi The enlarging spectrum of desminopathies: new morphological findings, eastward geographic spread, novel exon 3 desmin mutation
    Alexandra Vrabie
    Department of Neuropathology, Johannes Gutenberg University Medical Center, Langenbeckstrasse 1, 55101 Mainz, Germany
    Acta Neuropathol 109:411-7. 2005
    ..of the older brother revealed granulofilamentous material and plaques containing numerous proteins, foremost desmin, as did cardiac biopsy tissue...
  3. pmc Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements
    Wei Jiang
    College of Bioinformatics Science and Technology and Bio pharmaceutical Key Laboratory of Heilongjiang Province, Harbin Medical University, Harbin 150081, PR China
    BMC Syst Biol 2:72. 2008
    ..The aim of this study was thus to develop such a novel networking approach based on the relevance concept, which is ideal to reveal integrative effects of multiple genes in the underlying genetic circuit for complex diseases...
  4. ncbi High level desmin expression depends on a muscle-specific enhancer
    Z L Li
    Laboratoire de Biologie Moléculaire de la Différentiation Cellulaire, Universite Paris, France
    J Biol Chem 266:6562-70. 1991
    Expression of the desmin gene is increased several-fold during myogenesis. To identify the DNA sequences involved in this regulation, a 16-kilobase fragment containing a 4...
  5. ncbi Assignment of human desmin gene to band 2q35 by nonradioactive in situ hybridization
    E Viegas-Pequignot
    URA 620 CNRS, Structure et Mutagenèse Chromosomiques, Institut Curie, Paris, France
    Hum Genet 83:33-6. 1989
    A 3-kb DNA fragment, inserted in Bluescribe vector, was used to localize the desmin gene by in situ hybridization on human metaphase chromosomes. The probe was labelled by Bio-11-dUTP and detected by immunofluorescence...
  6. ncbi A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formation
    G Sjoberg
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Hum Mol Genet 8:2191-8. 1999
    In some myopathies of distal onset, the intermediate filament desmin is abnormally accumulated in skeletal and cardiac muscle...
  7. ncbi Progressive skeletal myopathy, a phenotypic variant of desmin myopathy associated with desmin mutations
    Marinos C Dalakas
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 4B37, 10 Central Drive, MSC 1361, Bethesda, MD 20892, USA
    Neuromuscul Disord 13:252-8. 2003
    b>Desmin myopathy is a familial or sporadic disorder characterized by the presence of desmin mutations that cause skeletal muscle weakness associated with cardiac conduction block, arrhythmia and heart failure...
  8. ncbi Small deletions disturb desmin architecture leading to breakdown of muscle cells and development of skeletal or cardioskeletal myopathy
    Anna Kaminska
    Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
    Hum Genet 114:306-13. 2004
    b>Desmin ( DES) mutations have been recognized as a cause of desmin-related myopathy (OMIM 601419), or desminopathy, a disease characterized by progressive limb muscle weakness and accumulation of desmin-reactive granular aggregates in the ..
  9. pmc A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture
    Gloria M Conover
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Mol Biol Cell 20:834-45. 2009
    b>Desmin interacts with nebulin establishing a direct link between the intermediate filament network and sarcomeres at the Z-discs...
  10. doi Disease mutations in the "head" domain of the extra-sarcomeric protein desmin distinctly alter its assembly and network-forming properties
    Sarika Sharma
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Mol Med (Berl) 87:1207-19. 2009
    The intermediate filament protein desmin generates an extra-sarcomeric network in myocytes. Mutations in the desmin gene cause myofibrillar myopathy characterized by desmin-positive aggregates and myofibrillar dissolution...
  11. doi Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene
    J Peter van Tintelen
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Rhythm 6:1574-83. 2009
    ..Mutations in the gene encoding desmin (DES), a major intermediate filament protein, can underlie this phenotype.
  12. doi Mutations in desmin's carboxy-terminal "tail" domain severely modify filament and network mechanics
    Harald Bär
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Mol Biol 397:1188-98. 2010
    Inherited mutations in the gene coding for the intermediate filament protein desmin have been demonstrated to cause severe skeletal and cardiac myopathies...
  13. doi Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks
    Ellen Otten
    Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands
    Heart Rhythm 7:1058-64. 2010
    Mutations in the gene encoding desmin (DES), an intermediate filament protein, underlie a heterogeneous phenotype, which is referred to as desmin-related myopathy (DRM)...
  14. doi Desmin-related myopathy
    K Y VAN Spaendonck-Zwarts
    Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Genet 80:354-66. 2011
    b>Desmin-related myopathy (DRM) is an autosomally inherited skeletal and cardiac myopathy, mainly caused by dominant mutations in the desmin gene (DES)...
  15. doi De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy
    Baerbel Klauke
    Herz and Diabeteszentrum NRW, Klinik f Thorax und Kardiovaskularchirurgie, Erich und Hanna Klessmann Institutfür Kardiovaskulaere Forschung und Entwicklung Klinik fuer angeborene Herzfehler, Georgstrasse 11, Bad Oeynhausen, Germany
    Hum Mol Genet 19:4595-607. 2010
    ..In 43% of the cohort, we found disease-associated sequence variants. In addition, we screened for desmin mutations and found a novel desmin-mutation p...
  16. doi Desmin mutations in the terminal consensus motif prevent synemin-desmin heteropolymer filament assembly
    Oussama Chourbagi
    University Paris Diderot Paris 7 CNRS EAC4413, Unit of Functional and Adaptive Biology, Laboratory of Stress and Pathologies of the Cytoskeleton, F 75013, Paris, France
    Exp Cell Res 317:886-97. 2011
    ..Synemin is a desmin-associated type VI intermediate filament protein. Neither its impact on desmin network nor how it integrates into desmin filament is yet elucidated...
  17. pmc Desmin-related cardiomyopathy: an unfolding story
    Patrick M McLendon
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Heart Circ Physiol 301:H1220-8. 2011
    The intermediate filament protein desmin is an integral component of the cardiomyocyte and serves to maintain the overall structure and cytoskeletal organization within striated muscle cells...
  18. pmc Dual color photoactivation localization microscopy of cardiomyopathy-associated desmin mutants
    Andreas Brodehl
    E and H Klessmann Institute for Cardiovascular Research and Development, Ruhr University Bochum, 32545 Bad Oeynhausen, Germany
    J Biol Chem 287:16047-57. 2012
    Mutations in the DES gene coding for the intermediate filament protein desmin may cause skeletal and cardiac myopathies, which are frequently characterized by cytoplasmic aggregates of desmin and associated proteins at the cellular level...
  19. ncbi Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development
    Z L Li
    Laboratoire de Biologie Moléculaire de la Différentiation Cellulaire, Universite Paris, France
    Gene 78:243-54. 1989
    A recombinant clone encoding for the human desmin gene (des) has been isolated and characterized and its complete nucleotide sequence has been determined. The 8.4-kb gene has nine exons separated by introns ranging in size from 0.1-2.2 kb...
  20. ncbi Human desmin gene: cDNA sequence, regional localization and exclusion of the locus in a familial desmin-related myopathy
    P Vicart
    Universite Paris VII, Paris, France
    Hum Genet 98:422-9. 1996
    b>Desmin is a muscle-specific intermediate filament that is encoded by a gene assigned to human chromosome 2q35. Desmin-related myopathies are inherited disorders characterized by an intrasarcoplasmic accumulation of desmin...
  21. pmc A dysfunctional desmin mutation in a patient with severe generalized myopathy
    A M Munoz-Marmol
    Fundación Echevarne, 08037 Barcelona, Spain
    Proc Natl Acad Sci U S A 95:11312-7. 1998
    Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile and degenerate upon repeated contractions...
  22. ncbi Molecular dissection of the interaction of desmin with the C-terminal region of nebulin
    Marie Louise Bang
    Department of Anesthesiology and Intensive Operative Care, Universitatsklinikum Mannheim, Mannheim, Germany
    J Struct Biol 137:119-27. 2002
    ..This identified that the nebulin modules M160 to M170 interact with desmin. In desmin, deletion series experiments assigned a 19-kDa central coiled-coil domain as the nebulin-binding site...
  23. pmc Desmin A213V substitution represents a rare polymorphism but not a mutation and is more prevalent in patients with heart dilation of various origins
    A Kostareva
    Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden
    Acta Myol 30:42-5. 2011
    Several desmin mutations have been described in patients with cardiomyopathies and distal myopathies...
  24. doi Biomechanical characterization of a desminopathy in primary human myoblasts
    Navid Bonakdar
    Department of Physics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Biochem Biophys Res Commun 419:703-7. 2012
    Heterozygous mutations of the human desmin gene on chromosome 2q35 cause hereditary and sporadic myopathies and cardiomyopathies...
  25. pmc Autosomal dominant myofibrillar myopathy with arrhythmogenic right ventricular cardiomyopathy 7 is caused by a DES mutation
    Carola Hedberg
    Department of Pathology, Institute of Biomedicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Eur J Hum Genet 20:984-5. 2012
    ..A heterozygous C-to-T transition, c.1255C>T, p.Pro419Ser in the desmin gene on chromosome 2q35, was identified. Previous studies had demonstrated linkage to chromosome 10q22...
  26. doi A novel heterozygous deletion-insertion mutation in the desmin gene causes complete atrioventricular block and mild myopathy
    Lingling Cao
    Department of Cardiology, the Second Affiliated Hospital of Nanchang University, Nanchang, PR China
    Clin Neuropathol 32:9-15. 2013
    Defects in the desmin gene have been identified in patients with cardiac and skeletal myopathy characterized by sarcoplasmic accumulation of desmin-positive deposits and electron dense granulofilamentous aggregates...
  27. ncbi Missense mutations in desmin associated with familial cardiac and skeletal myopathy
    L G Goldfarb
    Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland 20892, USA
    Nat Genet 19:402-3. 1998
    b>Desmin-related myopathy (OMIM 601419) is a familial disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-..
  28. pmc Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments
    Joy G Ghosh
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, United States
    Int J Biochem Cell Biol 39:1804-15. 2007
    ..in human alphaB crystallin that selectively interacted with native or partially unfolded filament proteins desmin, glial-fibrillary acidic protein, and actin...
  29. ncbi Desmin mutations in a St. Petersburg cohort of cardiomyopathies
    A Kostareva
    Department of Woman and Child Health, and Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Acta Myol 25:109-15. 2006
    Several desmin mutations have been described over the past few years in patients with dilated and restrictive cardiomyopathy, often in association with distal myopathy...
  30. doi Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy
    Johannes Levin
    Klinikum Grosshadern, Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
    J Neuropathol Exp Neurol 69:415-24. 2010
    Mutations in the intermediate filament protein desmin cause a distinct class of myofibrillar myopathies that are characterized by deposition of aggregated desmin...
  31. ncbi The human desmin locus: gene organization and LCR-mediated transcriptional control
    Jennifer L Y Tam
    Nuclear Biology Group, Department of Medical and Molecular Genetics, King s College London School of Medicine, King s College London Guy s Campus, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Genomics 87:733-46. 2006
    ..We report the first characterization of a muscle-cell-specific LCR, which is linked to the human desmin gene (DES)...
  32. ncbi Prevalence of desmin mutations in dilated cardiomyopathy
    Matthew R G Taylor
    University of Colorado at Denver and Health Sciences Center, Denver, Colo, USA
    Circulation 115:1244-51. 2007
    b>Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene...
  33. pmc Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin
    R L Shoeman
    Max Planck Institut für Zellbiologie, Ladenburg, Federal Republic of Germany
    Am J Pathol 142:221-30. 1993
    ..myofibrils treated in vitro with human immunodeficiency virus type 1 protease showed that myosin heavy chain, desmin, tropomyosin, and a fraction of the actin were all cleaved...
  34. ncbi Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments
    H Inada
    Division of Biochemistry, Aichi Cancer Center Research Institute, 1 1 Chikusa ku, Nagoya, Aichi 464 8681, Japan
    J Biol Chem 274:34932-9. 1999
    ..The balance between intermediate filament protein phosphorylation by Rho kinase and dephosphorylation by type 1 protein phosphatase may affect the ..
  35. ncbi Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases
    Montse Olive
    Institut de Neuropatologia, Ciutat Sanitaria i Universitaria de Bellvitge, C Feixa Llarga s n masculine, 08907 Hospitalet de Llobregat, Spain
    Acta Neuropathol 106:1-7. 2003
    ..skeletal and cardiac muscles have demonstrated that synemin localises at the Z-band, where it associates with desmin and alpha-actinin...
  36. pmc Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the rat
    A Ahluwalia
    Department of Biochemical Pharmacology, William Harvey Research Institute, St Bartholomew s Medical College, London
    Br J Pharmacol 108:544-8. 1993
    ....
  37. ncbi Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, University of Padua, Italy
    Horm Metab Res 32:265-8. 2000
    ..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH...
  38. pmc Involvement of B2 receptors in the bradykinin-induced relaxation of guinea-pig isolated trachea
    A da Silva
    Laboratoire de Neuroimmunopharmacologie, INSERM U405, , , Illkirch, France
    Br J Pharmacol 114:103-8. 1995
    ..The stimulation of B2-bradykinin receptors induces the activation of the cyclo-oxygenase pathway, leading either to contraction or relaxation depending on the tone of the trachea...
  39. ncbi Repellent activity of estrogenic compounds toward zoospores of the phytopathogenic fungus Aphanomyces cochlioides
    M T Islam
    Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
    Z Naturforsch C 56:253-61. 2001
    ..So far, this will be the first report of repellent activity of estrogenic compounds toward trivial fungal zoospores...
  40. pmc Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum
    F J Legat
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:453-60. 1994
    ..The present results might provide an experimental basis for clinical investigations of the effects of icatibant in infectious diseases where the release of collagenases from bacteria causes rapid spreading of inflammation...
  41. ncbi A randomized trial of chemotherapy with or without estrogenic recruitment in locally advanced breast cancer. North-West Oncology Group (GONO) Study, Italy
    E Baldini
    U.O. Oncologia Medica, Pisa, Italy
    Tumori 83:829-33. 1997
    ..Further research is needed to investigate different schedules of chemotherapy and hormones, or to test the possibility of combining various mitogens...
  42. pmc The effect of in vivo oestrogen pretreatment on the contractile response of rat isolated detrusor muscle
    R A Elliott
    Department of Medicine for the Elderly, Leicester General Hospital
    Br J Pharmacol 107:766-70. 1992
    ..8. These results suggest that oestradiol pretreatment had a modulating effect on cholinergic responses.The addition of oestrogen to the tissue environment enhances this inhibitory effect...
  43. ncbi Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene
    M C Dalakas
    Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1382, USA
    N Engl J Med 342:770-80. 2000
    Myofibrillar myopathies, often referred to as desmin-related myopathies, are a heterogeneous group of inherited or sporadic distal-onset skeletal myopathies associated with cardiomyopathy...
  44. ncbi Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratins
    Yoshiaki Hirako
    Unit of Biosystems, Graduate School of Human Informatics, Nagoya University, Nagoya, Japan
    Cell Tissue Res 313:195-207. 2003
    ..a monoclonal antibody, we have detected a high molecular weight muscle protein, co-localized and co-isolating with desmin. Searching a human cDNA database with partial amino acid sequences of the protein, we found a cDNA clone encoding ..
  45. pmc A missense mutation in desmin tail domain linked to human dilated cardiomyopathy promotes cleavage of the head domain and abolishes its Z-disc localization
    Manolis Mavroidis
    Cell Biology Division, Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    FASEB J 22:3318-27. 2008
    A missense mutation (Ile 451 to Met) at the tail domain of the muscle-specific intermediate filament protein desmin has been suggested to be a genetic cause of dilated cardiomyopathy...
  46. pmc Characterization of kinin receptors modulating neurogenic contractions of the mouse isolated vas deferens
    J Maas
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Brazil
    Br J Pharmacol 114:1471-7. 1995
    ....
  47. ncbi UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum
    K Stich
    TU Wien, , Technische Mikroskopie und Organische Rohstofflehre, Vienna, Austria
    Z Naturforsch C 52:153-8. 1997
    ..1 mu kat/kg protein) as substrate, indicating that hydroxylation of quercetin in 8-position to gossypetin precedes 7-O-glucosylation...
  48. pmc Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin
    H Li
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Cell Biol 124:827-41. 1994
    The muscle-specific intermediate filament protein, desmin, is one of the earliest myogenic markers whose functional role during myogenic commitment and differentiation is unknown...
  49. ncbi Molecular characteristics and interactions of the intermediate filament protein synemin. Interactions with alpha-actinin may anchor synemin-containing heterofilaments
    R M Bellin
    Muscle Biology Group, Department of Biochemistry, Iowa State University, Ames, Iowa 50011 3260, USA
    J Biol Chem 274:29493-9. 1999
    ..filament (IF)-associated protein because of its colocalization and copurification with the IF proteins desmin and vimentin in muscle cells...
  50. ncbi Desmin: molecular interactions and putative functions of the muscle intermediate filament protein
    M L Costa
    Laboratório de Diferenciação Muscular e Citoesqueleto, Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Braz J Med Biol Res 37:1819-30. 2004
    b>Desmin is the intermediate filament (IF) protein occurring exclusively in muscle and endothelial cells...
  51. ncbi Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle
    Denise Paulin
    Biologie Moleculaire de la Differenciation, Universite Paris, 75251 Paris, France
    Exp Cell Res 301:1-7. 2004
    b>Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles...
  52. ncbi Lower active force generation and improved fatigue resistance in skeletal muscle from desmin deficient mice
    J Balogh
    Department of Physiological Sciences, Lund University, BMC F11, Tornavagen 10, SE 221 84, Lund, Sweden
    J Muscle Res Cell Motil 24:453-9. 2003
    The mechanical effects of the intermediate filament protein desmin was examined in desmin deficient mice (Des-/-) and their wild type control (Des+/+)...
  53. ncbi Assembly properties of two CNBr fragments of avian desmin that correspond to the headpiece domain and helix 1B
    T Saeed
    Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267 0521
    Biochem Biophys Res Commun 165:1059-66. 1989
    To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions...
  54. pmc Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure
    Panagiota Panagopoulou
    Cell Biology Division, Center of Basic Research, and 2Cardiovascular Research Division, Center of Clinical Research, Biomedical Research Foundation, Academy of Athens, Athens 11527, Greece
    J Cell Biol 181:761-75. 2008
    We explored the involvement of the muscle-specific intermediate filament protein desmin in the model of tumor necrosis factor alpha (TNF-alpha)-induced cardiomyopathy...
  55. ncbi Interaction of [D-Trp6, Des-Gly10] LHRH ethylamide and hydroxy propyl beta-cyclodextrin (HPbetaCD): thermodynamics of interaction and protection from degradation by alpha-chymotrypsin
    K N Koushik
    Department of Pharmaceutical Sciences, 986025 University of Nebraska Medical Center, Omaha, NE 68198-6025, USA
    Pharm Dev Technol 6:595-606. 2001
    ..This inclusion, providing steric hindrance, may be one of the mechanisms by which HPbetaCD reduces enzymatic hydrolysis of deslorelin...
  56. ncbi Life-long effect of a single neonatal treatment with estradiol or progesterone on rat uterine estrogen receptor binding capacity
    G Csaba
    Department of Biology, Semmelweis University of Medicine, Budapest, Hungary
    Horm Metab Res 24:167-71. 1992
    ....
  57. ncbi [Role of B1 receptors in the endothelial protective effect of ischaemic preconditioning]
    J F Bouchard
    , , , Canada
    Arch Mal Coeur Vaiss 91:941-5. 1998
    ..B2 receptors do not play any role in that protection...
  58. ncbi Inhibition of the angiotensin converting enzyme by perindoprilat and release of nitric oxide
    B Desta
    Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Hypertens 8:1S-6S. 1995
    ..In addition, the response to perindoprilat may be due to factors other than just protection of bound bradykinin from degradation...
  59. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
    ..The effects of bradykinin were mediated by a B2 receptor...
  60. pmc Up-regulation of [3H]-des-Arg10-kallidin binding to the bradykinin B1 receptor by interleukin-1 beta in isolated smooth muscle cells: correlation with B1 agonist-induced PGI2 production
    J P Galizzi
    Cerep, Celle l evescault, France
    Br J Pharmacol 113:389-94. 1994
    ..This observation suggests that IL-1 but not LPS, in addition to increase in the number of receptors, signals the cell to permit the coupling of B1 receptors to the PLA2/cyclo-oxygenase pathway...
  61. ncbi Atriopeptin regulation and renal function in conscious spontaneously hypertensive rats
    J P Koepke
    Searle Research and Development, Department of Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110
    Am J Hypertens 3:622-7. 1990
    ..Compared to vehicle control rats, plasma APir was increased during coadministration of SC-46542 and thiorphan in both SHR (998 +/- 76 v 5.10 +/- 116 pg/mL) and WKY (775 +/- 36 v 414 +/- 36 pg/mL).(ABSTRACT TRUNCATED AT 250 WORDS)..
  62. pmc Mediation by B1 and B2 receptors of vasodepressor responses to intravenously administered kinins in anaesthetized dogs
    N Nakhostine
    Department of Physiology, Faculty of Medicine, , , Canada
    Br J Pharmacol 110:71-6. 1993
    ..These findings provide pharmacological evidence for the existence of functionally active B1 receptors in canine cardiovascular homeostasis...
  63. ncbi The effect of oxidation or alkylation on the separation of wool keratin proteins by two-dimensional gel electrophoresis
    Jeffrey E Plowman
    Wool Research Organisation of New Zealand, Christchurch, New Zealand
    Proteomics 3:942-50. 2003
    ..Peroxide treatment was found to have only a minor effect on the 2-DE separation of the intermediate filament protein (IFP) class...
  64. ncbi [Belgian law on the Régime de l'alcool of 1919: from the individual measures to social well-being]
    R Campos
    Departamento de Historia de la Ciencia, , CSIC
    Cuad Complut Hist Med Cienc 2:275-94. 1993
    ....
  65. ncbi [Mediastinitis after sternotomy. Mortality and hospital length of stay. Groupe parisien détude des sternotomies]
    J C Lucet
    , , Paris
    Arch Mal Coeur Vaiss 90:471-5. 1997
    ..The authors conclude that deep wound infection after sternotomy is responsible for almost doubling the duration of hospital stay. The economic consequences alone justify active research into the prevention of this complication...
  66. pmc Structural heterogeneity of the Fe(2+)-N epsilon (HisF8) bond in various hemoglobin and myoglobin derivatives probed by the Raman-active iron histidine stretching mode
    H Gilch
    Institute of Experimental Physics, University of Bremen, Germany
    Biophys J 65:1470-85. 1993
    ..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...
  67. pmc Polymorphous ventricular tachycardia following cardiopulmonary bypass
    L D Thompson
    Cardiothoracic Surgery Service, Valley Children Hospital, Fresno, California 93726, USA
    J Natl Med Assoc 88:49-51. 1996
    ..This case shows the effectiveness of intravenous magnesium in controlling Torsade des pointes in postoperative coronary bypass patients...
  68. pmc Pharmacological characterization of bradykinin receptors in canine cultured tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung College of Medicine and Technology, Tao Yuan, Taiwan
    Br J Pharmacol 114:67-72. 1995
    ..7 It is concluded that the pharmacological characteristics of the bradykinin receptors in canine cultured TSMCs are primarily of the B2 receptor subtype...
  69. ncbi Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein
    J E Ralton
    Department of Biochemistry, The University, Dundee, UK
    J Cell Sci 107:1935-48. 1994
    ..GFAP is the only type III intermediate filament protein in which this motif is not readily identified...
  70. ncbi [Evidence for a glomerular receptor for bradykinin in rats. Effect of sodium intake on density and affinity of the receptor]
    J L Bascands
    INSERM U 133, , Toulouse
    Arch Mal Coeur Vaiss 82:1219-22. 1989
    ..45 +/- 1.3 and 13.25 +/- 1.17 fmol/mg protein).(ABSTRACT TRUNCATED AT 250 WORDS)..
  71. ncbi [The Musée du service de santé des armeés in Val-de-Grâce]
    J J Ferrandis

    Hist Sci Med 33:183-90. 1999
    ..The visitor may also discover the marvelous mortars and pharmacy pots collection of the doctors Debat...
  72. pmc The role of bradykinin B1 receptors in the maintenance of intra-articular plasma extravasation in chronic antigen-induced arthritis
    S C Cruwys
    Inflammation Group, London Hospital Medical College
    Br J Pharmacol 113:940-4. 1994
    ..The data presented in this study suggest an evolving role for B1 receptors in the mediation of plasma extravasation in inflamed joint tissues. A role for BK antagonists in the treatment of arthritis is also suggested...
  73. ncbi Effects of neonatal diethylstilbestrol (DES) exposure on morphology and growth patterns of endometrial epithelial cells in CD-1 mice
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 27:325-33. 1999
    ..The data show that cell cycle kinetics, in addition to changes in morphology, are altered in the developing mouse uterus following neonatal exposure to DES...
  74. pmc Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505
    F Pons
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 109:234-42. 1993
    ..However, they question the role of PAF receptors on platelets in this model. The results also indicate that PAF may be involved in platelet accumulation induced by zymosan in rabbit skin...
  75. ncbi Connexin 43 expression in glial cells of developing rhombomeres of Xenopus laevis
    Bharti Katbamna
    Department of Speech Pathology and Audiology, Western Michigan University, Kalamazoo, MI 49008 5355, USA
    Int J Dev Neurosci 22:47-55. 2004
    ..Xenopus rhombomeres and then tracked expression of connexin 43 and glial fibrillary acidic protein, an intermediate filament protein known to mark glia during rhombomeric development...
  76. pmc Regulation of vimentin intermediate filaments in endothelial cells by hypoxia
    Tiegang Liu
    Pulmonary and Critical Care Division, Department of Medicine Tupper Research Institute, Tufts Medical Center, and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Physiol Cell Physiol 299:C363-73. 2010
    ..We now show that vimentin, a major intermediate filament protein in endothelial cells, is regulated by hypoxia...
  77. ncbi The IAEA/WHO TL dosimetry service for radiotherapy centres 1969-87
    H Svensson
    International Atomic Energy Agency, Vienna, Austria
    Acta Oncol 29:461-7. 1990
    ..7%. About 5% of the centres had deviations larger than 30%, at least on one occasion. It is shown that the accuracy in dosimetry improves considerably for those departments participating more than once in the TL dosimetry service...
  78. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ....
  79. pmc Vasopressin-stimulated [3H]-inositol phosphate and [3H]-phosphatidylbutanol accumulation in A10 vascular smooth muscle cells
    R Plevin
    Department of Biochemistry, University of Glasgow
    Br J Pharmacol 107:109-15. 1992
    ....
  80. ncbi Lens membrane fraction associated intermediate filaments of different aged rats
    Charles Ricky Fleschner
    Department of Biochemistry, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA
    Curr Eye Res 24:296-304. 2002
    ..To describe the intermediate filament proteins vimentin, filensin and phakinin associated with different fractions isolated from neonatal, 10 day old and 20 day old rat lenses...
  81. ncbi Lysosomal enzymes in pregnant and steroid treated rats
    A Isaksson
    Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Horm Metab Res 20:274-7. 1988
    ..No significant changes were observed for the other two enzymes. Thus, steroid treatment did not fully reproduce the enzyme changes seen in pregnancy, which may indicate that these are not solely due to a hormone effect...
  82. ncbi A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein
    Y Chan
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637
    Genes Dev 8:2574-87. 1994
    ....
  83. ncbi Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo in Locusta
    M J Lee
    Department of Biology, Birkbeck College, University of London, London, UK
    J Comp Physiol B 166:61-7. 1996
    ..The different responses exploited in these assays may be exerted through different receptor populations...
  84. pmc Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse
    C R Correa
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis SC, Brazil
    Br J Pharmacol 110:193-8. 1993
    ..In addition, the current results also demonstrate that the inflammatory oedema associated with the later phase of formalin-induced pain seems to be mediated by endogenous BK, via activation of B2 receptors...
  85. pmc Vasoconstrictor effects of various neuropeptide Y analogues on the rat tail artery in the presence of phenylephrine
    M Tschopl
    Laboratoire de Pharmacologie Cellulaire et Moleculaire, C N R S URA 600, Universite Louis Pasteur Strasbourg, Illkirch, France
    Br J Pharmacol 110:1098-104. 1993
    ..The effects of [des-Ser3,Lys4]D-Cys2-NPY indicate that the Y1-receptor may possess an allosteric binding site...
  86. ncbi Expression and distribution of cytokeratins and vimentin in rat larynx and trachea following irradiation
    S Bartel-Friedrich
    Department of Otorhinolaryngology, Phoniatrics and Pedaudiology Section, University Hospital, Martin Luther University Halle Wittenberg, Germany
    Anticancer Res 27:2059-69. 2007
    ..However, reports on radiogenic intermediate filament protein alterations in laryngeal-tracheal tissues are very rare...
  87. ncbi Hemodynamic effects of atrial natriuretic factor clearance receptor occupancy in conscious sheep
    D G Parkes
    Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Australia
    Am J Hypertens 3:829-32. 1990
    ..These studies support the concept of the metabolism of ANF via clearance receptors, suggesting that long-term hemodynamic actions of endogenous ANF may be achieved via prolonged blockade of these clearance receptors...
  88. pmc [Serodiagnosis of toxoplasmosis: a comparative multicenter study of a standard scale through various actual tests and expression of the results in international units. Groupe de travail toxoplasmose du Contrôle national de qualité en parasotologie. Synd
    J C Petithory
    Service de Biologie, , Centre Hospitalier, Gonesse, France
    Bull World Health Organ 74:291-8. 1996
    ..It is therefore essential that the conditions and limits for a positive reaction be carefully defined in each case, especially for commercially available kits...
  89. ncbi Differential expressions of protein kinase C isozymes during proliferation and differentiation of human skeletal muscle cells in vitro
    J Boczan
    Department of Physiology and Cell Physiology, University Medical School of Debrecen, Hungary
    Acta Neuropathol 99:96-104. 2000
    ..The expressions of desmin, used as a muscle-specific intermediate filament protein marker of differentiation, and of different PKC isozymes were detected by single and double ..
  90. ncbi Abnormal cell differentiation and p21 expression of endometrial epithelial cells following developmental exposure to diethylstilbestrol (DES)
    A Yoshida
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:237-45. 2000
    ....
  91. ncbi Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation
    A Sandilands
    Department of Biochemistry, The University, Dundee, UK
    J Cell Sci 108:1397-406. 1995
    The cells of the eye lens contain the type III intermediate filament protein vimentin, as well as two other intermediate filament proteins, CP49 and filensin. These two proteins appear to be unique to the differentiated lens fibre cell...
  92. ncbi [The war victim]
    P Hugeux
    , , Clamart
    Bull Acad Natl Med 178:1357-63; discussion 1363-4. 1994
    ..These joint actions, added to the ones of very influential autonomous associations, contribute to give handicapped war victims an honourable citizenship...
  93. ncbi [The Hypertension Cochrane Review Group. Presentation and user's guide]
    F Gueyffier
    , Service de Pharmacologie Clinique, Lyon
    Arch Mal Coeur Vaiss 90:1159-63. 1997
    ..The second edition in 1996 of the Cochrane Library included 114 systematic reviews and 131 protocols, being the only media with similar objectives...
  94. pmc Mechanisms of bradykinin-induced contraction of the guinea-pig gallbladder in vitro
    D A Cabrini
    Universidade Federal de Santa Catarina, , Brazil
    Br J Pharmacol 114:1549-56. 1995
    ....
  95. pmc Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:21-8. 1994
    ..The transduction mechanism of BK coupled to PI hydrolysis is sensitive to feedback regulation by PKC...
  96. pmc Type II intermediate-filament proteins from wool. The amino acid sequence of component 5 and comparison with component 7c
    L G Sparrow
    C S I R O Division of Wool Technology, Parkville, Vic, Australia
    Biochem J 282:291-7. 1992
    ....
  97. ncbi Simultaneous expression of keratin and glial fibrillary acidic protein by the same cells in epiretinal membranes
    S A Vinores
    Department of Ophthalmology and Neuroscience, Johns Hopkins University Hospital, Baltimore, Maryland
    Invest Ophthalmol Vis Sci 33:3361-6. 1992
    ..Examination of intermediate filament protein content by immunocytochemical analysis can help to identify some cells with altered ultrastructure but ..
  98. ncbi A new marker for cup cells in the rabbit small intestine: expression of vimentin intermediate filament protein
    Y Fujimura
    Division of Gastroenterology, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    Med Electron Microsc 34:223-9. 2001
    ..In rabbit small intestine, vimentin is useful for the detection of cup cells, as well as M cells, and may facilitate the investigation of these little understood cells...
  99. ncbi The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413
    Olaf Bossinger
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, D 40225 Duesseldorf, Germany
    Dev Biol 268:448-56. 2004
    ..We demonstrate that: (i) the widely used monoclonal antibody MH33 reacts (only) with the gut-specific intermediate filament protein encoded by the ifb-2 gene; (ii) IFB-2 protein accumulates near the gut lumen beginning at the lima ..
  100. ncbi In vitro assembly properties of mutant and chimeric intermediate filament proteins: insight into the function of sequences in the rod and end domains of IF
    Lisa Gu
    Molecular and Cell Biology Graduate Program, University of Maryland Biotechnology Institute, Baltimore 21201, USA
    Exp Cell Res 298:249-61. 2004
    ..either mutated or swapped between a cytoplasmic (mouse neurofilament-light (NF-L) subunit) and nuclear intermediate filament protein (human lamin A)...
  101. ncbi Novel cell lines derived from adult human ventricular cardiomyocytes
    Mercy M Davidson
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Mol Cell Cardiol 39:133-47. 2005
    ..heavy chain, alpha-cardiac actin, troponin I, desmoplakin, alpha actinin, the muscle-specific intermediate filament protein, desmin, the cardiomyocyte-specific peptide hormones, BNP, the L-type calcium channel alpha1C subunit ..

Research Grants34

  1. INTERFERON EFFECTS ON INTERMEDIATE FILAMENTS IN TUMOR CE
    DIANNE BUCKMAN; Fiscal Year: 1992
    ..not only a better understanding of the relationship between the actions of the interferons and intermediate filament protein and gene expression but also contributing information towards a broader biological understanding of ..
  2. Discovery of Novel Autoantigens in Patients with Inclusion Body Myositis
    KEVIN C O'CONNOR; Fiscal Year: 2013
    ..We discovered that a muscle intermediate filament protein was recognized by IBM tissue-derived immunoglobulin...
  3. Alexander Disease: Cellular and Molecular Mechanisms
    Albee Messing; Fiscal Year: 2012
    ..neurodegenerative disease that results from heterozygous mutations in the gene encoding the type III intermediate filament protein GFAP...
  4. Intermediate filament cytoskeleton and cell shape in Caulobacter crescentus
    Christine Jacobs Wagner; Fiscal Year: 2009
    ..This study of crescentin, a bacterial version of an intermediate filament protein, is likely to provide insight into the way its human counterparts assemble and function within cells...
  5. MOLECULAR REGULATION OF INTERMEDIATE FILAMENT STRUCTURE
    Robert Evans; Fiscal Year: 1991
    ..The proposed experiments will use the intermediate filament protein vimentin as a model for phosphorylation regulated filament organization...
  6. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    ..One protein that may be involved in localizing cGMP kinase to substrates is the cytoskeletal intermediate filament protein vimentin...
  7. Adam I Marcus; Fiscal Year: 2015
    ..Numerous reports show that the intermediate filament protein vimentin is overexpressed in invasive human tumors but is nearly undetectable in non- invasive, ..
  8. Role of Vimentin, sPLA2 and LysoPC in Autoimmune Disease
    SUZANNE BARBOUR; Fiscal Year: 2005
    ..The "receptor" for this pool of sPLA2 is the rod domain of vimentin, an intermediate filament protein that is exposed when cells undergo apoptosis...
  9. EPITHELIO MESENCHYMAL TRANSITION IN BREAST CANCER
    Erik Thompson; Fiscal Year: 2001
    ..Expression of the mesenchymal cell intermediate filament protein vimentin (VIM) has been used traditionally as a marker of the EMT...
  10. K P CONNIE TAM; Fiscal Year: 2016
    ..of antimicrobial peptides (KDAMPs), which are glycine-rich C-terminal fragments of keratin 6A, a major intermediate filament protein found in the cytoskeleton of a wide range of epithelial cells...
  11. GROWTH FACTOR CONTROL OF UTERINE CELL FUNCTION IN VITRO
    Daniel Carson; Fiscal Year: 1992
    ..These responses include altered patterns of glycoprotein and ECM expression, intermediate filament protein (desmin) expression and prostaglandin (PG) secretion...
  12. Skeletal Muscle Injury: Mechanism Prevention & Treatment
    Richard Lieber; Fiscal Year: 2007
    ..3) to measure the relative strengthening ability of normal muscles compared to muscles devoid of the intermediate filament protein desmin...
  13. RODNEY J ROTHSTEIN; Fiscal Year: 2014
    ..We will further characterize the role of the Shu suppressor complex (Shu1/Shu2/Psy3/Csm2) in en-or-free repair...
  14. WILLIAM GAINES; Fiscal Year: 2014
    ..The goal of this project is to elucidate the functional role of the Shu1-Shu2-Csm2-Psy3 (Shu) complex of S. cerevisiae...
  15. Primaquine-binding proteins identified in Pneumocystis
    SHERRY QUEENER; Fiscal Year: 2006
    ..Preliminary identification of one of these proteins suggests it is an intermediate filament protein, which may relate to the profound cytoplasmic disruption produced in Pneumocystis by 8-aminoquinolines...
  16. SWITCHING IN CANDIDA ALBICANS
    David Soll; Fiscal Year: 1990
    ..budding pattern, zones of cell wall expansion, chitin deposition, and dynamics of actin, tubulin and intermediate filament protein localization which may accompany switching, 4) to complete the characterization of high frequency ..
  17. PTP1C INCREASES IN THE DEAFFERENTED AUDITORY BRAINSTEM
    DIANA LURIE; Fiscal Year: 2001
    ..morphological changes; including proliferation, process extension, and increased levels of the glial intermediate filament protein, GFAP...
  18. INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONS
    Robert Goldman; Fiscal Year: 2008
    ..The latter include the formation of Mallory bodies in alcoholic liver disease and Lewy bodies in Parkinson's disease. ..
  19. FUNCTION OF GFAP IN ASTROCYTE DEVELOPMENT AND DISEASE
    Albee Messing; Fiscal Year: 2002
    ..In specific aim 3, he will test the hypothesis that formation of Rosenthal fibers in astrocytes is associated with fundamental physiological changes in astrocytes and in neuron-glial interactions. ..
  20. Lens plasma membrane-cytokeleton in selenite cataract
    CHARLES FLESCHNER; Fiscal Year: 2003
    ..Also, these studies will describe changes in the cytoskeletal network which are associated with the formation of cataracts. It is anticipated this information will be useful in the understanding of human senile cataract. ..
  21. Nanospheres as Vehicles for Treatment of Neuroblastoma
    Thomas Shea; Fiscal Year: 2004
    ..Resulting data will indicate whether or not nanospheres represent useful delivery agents for cancer therapy. ..
  22. LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTION
    Robert D Goldman; Fiscal Year: 2010
    ..These collective studies will provide important insights into how hLA mutations cause the defects seen in progeria. ..
  23. Diabetes Mellitus and Astrocyte Regulation of Glutamate
    Elaine Coleman; Fiscal Year: 2005
    ..In summary, this application targets the role of altered astrocyte activity and glutamate uptake in diabetes-induced CNS disorders. ..
  24. Intermediate Filaments 2008 Gordon Research Conference
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Endothelial Cell Migration and Retinal Angiogenesis
    Robert Fischer; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  26. EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTS
    Anna Lysakowski; Fiscal Year: 2008
    ..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
  27. Is S-adenosyl Methionine a Nutrition: Genetic Link in AD?
    Thomas Shea; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Improving Waisman Center Animal Care Facility
    Albee Messing; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. Import of Adenovirus DNA into the nucleus
    Larry Gerace; Fiscal Year: 2007
    ..Finally, it could provide the basis for developing efficient means for nonviral gene transfer, which would be useful for gene therapy and functional studies of cells. ..
  30. Familial Dilated Cardiomyopathy:Genetic Characterization
    Matthew Taylor; Fiscal Year: 2006
    ..In addition, a diverse collection of consultants has been assembled to provide ongoing expertise that is sensitive to the needs of both the research and career development plans of the candidate. ..
  31. Is a therapy for Alexander disease already FDA-approved?
    Albee Messing; Fiscal Year: 2006
    ..By restricting the focus to the FDA-approved list, successful identification of GFAP-suppressing drugs could offer immediate therapeutic benefit to Alexander disease patients. ..
  32. INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONS
    Robert D Goldman; Fiscal Year: 2010
    ....
  33. Screen for Small Molecule Inhibitors of Nuclear Protein Import
    Larry Gerace; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  34. MECHANISMS OF NUCLEAR IMPORT
    Larry Gerace; Fiscal Year: 2006
    ..Thus, understanding basic nuclear transport mechanisms can provide a framework for developing new therapeutic approaches relevant to viral pathogenesis, cancer and immunity and other processes. ..