DDIT3

Summary

Gene Symbol: DDIT3
Description: DNA damage inducible transcript 3
Alias: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3 protein, C/EBP zeta, CCAAT/enhancer-binding protein homologous protein, DDIT-3, c/EBP-homologous protein 10, growth arrest and DNA damage-inducible protein GADD153
Species: human

Top Publications

  1. pmc CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
    Sophie C Cazanave
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 299:G236-43. 2010
  2. pmc Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    Mélaine Minville-Walz
    Universite de Bourgogne, Centre de Recherche INSERM Lipides, Nutrition, Cancer UMR866, Dijon, France
    PLoS ONE 5:e14363. 2010
  3. ncbi The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor
    Allyson L Anding
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 67:6270-7. 2007
  4. ncbi Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes
    Galina Chipitsyna
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 207:605-13. 2006
  5. pmc Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein
    Jun Fujii
    Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Infect Immun 76:3679-89. 2008
  6. ncbi Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)
    P Aman
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 5:278-85. 1992
  7. ncbi Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
    T H Rabbitts
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Genet 4:175-80. 1993
  8. pmc Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10
    B P Chen
    Ohio State Biochemistry Program, Ohio State University, Columbus, 43210, USA
    Mol Cell Biol 16:1157-68. 1996
  9. ncbi Fusion of the EWS and CHOP genes in myxoid liposarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Oncogene 12:489-94. 1996
  10. ncbi Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
    X Z Wang
    Department of Medicine, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 10016, NY, USA
    Science 272:1347-9. 1996

Research Grants

  1. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
  2. Trial of mesna to prevent doxorubicin-induced plasma protein oxidation and TNFa r
    Jeffrey A Moscow; Fiscal Year: 2012
  3. Qinghua Sun; Fiscal Year: 2015
  4. Randal J Kaufman; Fiscal Year: 2014
  5. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
  6. Zhiyong Zhao; Fiscal Year: 2016
  7. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
  8. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
  9. Marina Gorbatyuk; Fiscal Year: 2014
  10. Matthew M Lavail; Fiscal Year: 2014

Detail Information

Publications386 found, 100 shown here

  1. pmc CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
    Sophie C Cazanave
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 299:G236-43. 2010
    ..facilitates PUMA expression by saturated FFA, the transcription factor CAAT/enhancer binding homologous protein (CHOP) is also induced by ER stress and promotes apoptosis...
  2. pmc Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
    Mélaine Minville-Walz
    Universite de Bourgogne, Centre de Recherche INSERM Lipides, Nutrition, Cancer UMR866, Dijon, France
    PLoS ONE 5:e14363. 2010
    ..g., oleic acid). Several reports demonstrated that inhibition of Scd1 led to the blocking of proliferation and induction of apoptosis in cancer cells. Nevertheless, mechanisms of cell death activation remain to be better understood...
  3. ncbi The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor
    Allyson L Anding
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cancer Res 67:6270-7. 2007
    ..characterize the mechanism of action of 4-HBR, expression of the endoplasmic reticulum stress-induced genes GADD153 and Bcl-2-binding component 3 was examined...
  4. ncbi Cooperativity between Rad51 and C/EBP family transcription factors modulates basal and Tat-induced activation of the HIV-1 LTR in astrocytes
    Galina Chipitsyna
    Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 207:605-13. 2006
    ..cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP)...
  5. pmc Shiga toxin 2 causes apoptosis in human brain microvascular endothelial cells via C/EBP homologous protein
    Jun Fujii
    Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Infect Immun 76:3679-89. 2008
    ..a marked upregulation of C/EBP homologous protein (CHOP)/growth arrest and DNA damage-inducible protein 153 (GADD153). Increased CHOP expression was dependent on enzymatically active Stx1...
  6. ncbi Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)
    P Aman
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Genes Chromosomes Cancer 5:278-85. 1992
    ..We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question...
  7. ncbi Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
    T H Rabbitts
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nat Genet 4:175-80. 1993
    ..We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-..
  8. pmc Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10
    B P Chen
    Ohio State Biochemistry Program, Ohio State University, Columbus, 43210, USA
    Mol Cell Biol 16:1157-68. 1996
    ..We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional heterodimer with ATF3: the heterodimer, in contrast to the ATF3 homodimer, does not ..
  9. ncbi Fusion of the EWS and CHOP genes in myxoid liposarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Sweden
    Oncogene 12:489-94. 1996
    ..t(12;16)(q13;p11), which cytogenetically characterizes myxoid liposarcomas (MLS), results in a fusion of the CHOP gene in 12q13 and the FUS gene in 16p11, creating a chimeric FUS/CHOP gene...
  10. ncbi Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
    X Z Wang
    Department of Medicine, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 10016, NY, USA
    Science 272:1347-9. 1996
    b>CHOP, a member of the C/EBP family of transcription factors, mediates effects of cellular stress on growth and differentiation...
  11. pmc CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins
    M Ubeda
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell Biol 19:7589-99. 1999
    The transcription factor CHOP (C/EBP homologous protein 10) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death...
  12. ncbi The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP)
    F Gachon
    Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS EP 2104 Université Montpellier I, Institut de Biologie, 4 Bd Henri IV, 34060 Montpellier, France
    FEBS Lett 502:57-62. 2001
    ..Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription...
  13. pmc Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR
    C Jousse
    UR 238 Unité de Nutrition Cellulaire et Moléculaire, INRA de Theix, 63122 Saint Genes Champanelle, France
    Nucleic Acids Res 29:4341-51. 2001
    b>Chop is a ubiquitously expressed mammalian gene encoding a small nuclear protein related to the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors...
  14. ncbi Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
    Tomomi Gotoh
    Department of Molecular Genetics, Kumamoto University School of Medicine, Kumamoto 860 0811, Japan
    J Biol Chem 277:12343-50. 2002
    ..On the other hand, mRNA and protein for CHOP, a transcription factor known to be induced by endoplasmic reticulum (ER) stress, were induced...
  15. pmc CCAAT/enhancer-binding proteins: structure, function and regulation
    Dipak P Ramji
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, P O Box 911, Cardiff CF10 3US, Wales, U K
    Biochem J 365:561-75. 2002
    ..This review deals with the structure, biological function and the regulation of the C/EBP family...
  16. ncbi Comprehensive identification of human bZIP interactions with coiled-coil arrays
    John R S Newman
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Science 300:2097-101. 2003
    ..Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response...
  17. ncbi Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
    Julien Averous
    Unité de Nutrition et Métabolisme Protéique, Institut National de la Recherche Agronomique de Theix, 63122 Saint Genes Champanelle, France
    J Biol Chem 279:5288-97. 2004
    The CHOP gene is transcriptionally induced by amino acid starvation...
  18. ncbi Roles of CHOP/GADD153 in endoplasmic reticulum stress
    S Oyadomari
    Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Cell Death Differ 11:381-9. 2004
    ..pathway is C/EBP homologous protein (CHOP), also known as growth arrest- and DNA damage-inducible gene 153 (GADD153)...
  19. ncbi Curcumin-induced GADD153 gene up-regulation in human colon cancer cells
    David W Scott
    Cellular and Molecular Nutrition Research Laboratory, Graduate Program in Nutrition, The University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    Carcinogenesis 25:2155-64. 2004
    ..could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered...
  20. ncbi CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
    Hirohito Yamaguchi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Department of Interdisciplinary Oncology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 279:45495-502. 2004
    ..Here, we provide evidence that CHOP is involved in THG up-regulation of DR5, which is a critical step for ER stress-induced apoptosis in human cancer ..
  21. ncbi Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression
    Melker Göransson
    Lundberg Laboratory for Cancer Research LLCR, Department of Pathology, Goteborg University, Gothenburg, Sweden
    Int J Cancer 115:556-60. 2005
    The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3...
  22. pmc TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    Nobumichi Ohoka
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
    EMBO J 24:1243-55. 2005
    C/EBP homologous protein (CHOP) is a stress-inducible nuclear protein that is crucial for the development of programmed cell death and regeneration; however, the regulation of its function has not been well characterized...
  23. doi Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)
    Yasuhiro Tagawa
    Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409 3898, Japan
    Free Radic Biol Med 45:50-9. 2008
    ..Exposure of hBEC to CS or CS extract (CSE) caused expression of endogenous ER stress markers GRP78 and CHOP and induction of apoptosis evidenced by nuclear condensation, membrane blebbing, and activation of caspase-3 and ..
  24. doi The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ
    M Goransson
    Lundberg Laboratory for Cancer Research LLCR, Department of Pathology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Oncogene 28:270-8. 2009
    ..The FUS-DDIT3 fusion oncogene results from a t(12;16)(q13;p11) chromosome translocation and has a causative role in the ..
  25. pmc C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
    Nan Su
    Department of Biochemistry and Molecular Biology, Shands Cancer Center and Center for Nutritional Sciences, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 283:35106-17. 2008
    C/EBP homology protein (CHOP), a stress-induced transcription factor, is involved in transcriptional regulation, cell cycle, and apoptosis...
  26. pmc CHOP and the endoplasmic reticulum stress response in myelinating glia
    Alexander Gow
    Wayne State University, 3217 Scott Hall, 540 E Canfield, Detroit, MI, USA
    Curr Opin Neurobiol 19:505-10. 2009
    ..studies conclude that this stress response is adaptive but, nevertheless, includes maladaptive programs involving CHOP expression that drives cell-autonomous apoptosis...
  27. pmc Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
    Yi Jiun Chen
    Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
    Nucleic Acids Res 38:764-77. 2010
    ..b>CHOP, a downstream transcriptional target of stress-induced ATF4, is also regulated translationally in a uORF-dependent ..
  28. pmc Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells
    Chunli Shao
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
    J Biol Chem 285:19710-9. 2010
    ..kinase (MAPK) signaling pathways regulate the expression of CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates endoplasmic reticulum stress-induced apoptosis...
  29. pmc Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation
    Lakshmi Reddy Palam
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:10939-49. 2011
    ..One ISR target gene encodes the transcriptional regulator CHOP whose accumulation is critical for stress-induced apoptosis...
  30. doi FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells
    Rene Rodriguez
    Andalusian Stem Cell Bank, Centro de Investigacion Biomedica, Consejería de Salud Universidad de Granada, Granada, Spain
    Stem Cells 29:179-92. 2011
    ..FUS (FUsed in Sarcoma; also termed TLS, Translocated in LipoSarcoma)-CHOP (C/EBP HOmologous Protein; also termed DDIT3, DNA Damage-Inducible Transcript 3), a hallmark mixoid liposarcoma-associated fusion oncogene, in wild-type and ..
  31. pmc Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation
    Joel Alter
    Department of Biochemistry, Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 6:e29498. 2011
    ..the α subunit of the translation initiation factor 2 (eIF2α) is followed by expression of C/EBP homology protein (CHOP) in some myoblasts...
  32. pmc Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153
    Alexandra Jauhiainen
    Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 7:e33208. 2012
    DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family...
  33. pmc The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma
    L E Dalton
    Division of Respiratory Medicine, Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Br J Cancer 108:1340-7. 2013
    ..When faced with elevated levels of secretory protein load, cells are said to experience ER stress, which has been implicated in the pathogenesis of many human diseases including cancer...
  34. pmc CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model
    Viviana Scaiewicz
    Institute for Drug Research, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
    PLoS ONE 8:e81065. 2013
    C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism...
  35. pmc The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis
    Diane Dezwaan-McCabe
    Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America
    PLoS Genet 9:e1003937. 2013
    ..Here we provide multiple lines of evidence demonstrating that the ISR-regulated transcription factor CHOP promotes liver cancer...
  36. ncbi CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
    D Ron
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston
    Genes Dev 6:439-53. 1992
    ..and dimerization domain "zipper probe" was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10...
  37. ncbi Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma
    A Crozat
    Department of Medicine, NYU Medical Center, New York 10016
    Nature 363:640-4. 1993
    ..translocation, t(12;16)(q13;p11), that is associated with a structural rearrangement of the gene encoding CHOP, a growth arrest and DNA-damage inducible member of the C/EBP family of transcription factors residing on 12q13.1...
  38. ncbi Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis
    K Cui
    Laboratory for Cell and Molecular Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:7591-6. 2000
    The transcription factor CHOP (GADD153) heterodimerizes with other C/EBP family members, especially C/EBPbeta, thus preventing their homodimerization and binding to DNA sequences specific for the homodimers...
  39. ncbi Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis
    Dianhua Qiao
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 53792 8550, USA
    Biochim Biophys Acta 1583:108-16. 2002
    ..In this study, we examined the effect of DCA on the GADD153 (growth arrest- and DNA damage-inducible gene 153) proapoptotic gene and its role in DCA-induced apoptosis in a ..
  40. ncbi Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells
    Kyung Ran You
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute for Medical Science, Chonbuk National University Medical School and Hospital, Chonju, Chonbuk, South Korea
    Hepatology 38:745-55. 2003
    The transcription factor CHOP/GADD153 is reportedly induced by cellular stresses such as UV light, genotoxic agents, and protein misfolding in the endoplasmic reticulum...
  41. ncbi Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes
    Yuan Ji Pan
    Cellular and Molecular Nutrition Research Laboratory, Graduate Program in Nutrition, The University of North Carolina at Greensboro, NC 27402 6170, USA
    Biochim Biophys Acta 1691:41-50. 2004
    ..In contrast, there was mainly increased mRNA expression of Growth Arrest and DNA Damage-inducible gene 153 (GADD153), which seemed to be at the level of transcription rather than mRNA stability...
  42. ncbi Decreased expression of CCAAT/enhancer binding protein zeta (C/EBPzeta) in patients with different myeloid diseases
    Jun Qian
    The Department of Hematology, The First People s Hospital of Zhenjiang, Zhenjiang, Jiangsu 212002, PR China
    Leuk Res 29:1435-41. 2005
    ..C/EBPzeta, also known as GADD153, CHOP10, and DDIT3 has been found associated with the development of myxoid liposarcoma and the progression of ..
  43. pmc The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells
    Katarina Engström
    Department of Oncology, Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Gothenburg, Sweden
    Am J Pathol 168:1642-53. 2006
    ..Most MLS/RCLS carry a t(12;16) translocation, resulting in a FUS-DDIT3 fusion gene...
  44. ncbi Celecoxib and a novel COX-2 inhibitor ON09310 upregulate death receptor 5 expression via GADD153/CHOP
    Q He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 27:2656-60. 2008
    ..We also show that both agents engage GADD153/CHOP to transcriptionally upregulate DR5 expression; GADD153/CHOP is a C/EBP homologous transcription factor ..
  45. pmc Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress
    Vinay K Singh
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Mol Biol 380:313-26. 2008
    ..The C/EBP homologous protein (CHOP) is a proto-oncogene, traditionally shown as a dominant-negative inhibitor of C/EBPs and a transcriptional ..
  46. doi Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements
    Simon C M Kwok
    Department of Pathology and Laboratory Medicine, Albert Einstein Medical Center, Philadelphia, PA 19141 3098, USA
    Mol Cell Biochem 319:203-8. 2008
    ..RT-PCR analyses showed up-regulation of CHOP/GADD153 and splicing of XBP-1 mRNA in brefeldin A-treated cells...
  47. doi CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians
    Claudia Gragnoli
    Molecular Biology Laboratory, Bios Biotech Multi Diagnostic Health Center, Rome, Italy
    J Cell Physiol 217:291-5. 2008
    ..The chromosome 12q13.1 region is in linkage to T2D in different populations, including our Italian dataset. CHOP is a candidate gene for the linkage, as it is located in the chromosome 12q13...
  48. doi Up regulation of the GRP-78 and GADD-153 and down regulation of Bcl-2 proteins in primary glomerular diseases: a possible involvement of the ER stress pathway in glomerulonephritis
    Suchita Markan
    Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Mol Cell Biochem 324:131-8. 2009
    ..05). Our results suggest that renal injury in PGD is associated with ER stress and ER stress may be involved in the rapid progression of PGN to renal failure...
  49. pmc DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2
    Christoffer Bento
    Lundberg Laboratory for Cancer Research, Department of Pathology, University of Gothenburg, Gothenburg, Sweden
    BMC Cell Biol 10:89. 2009
    The DDIT3 gene encodes a transcription factor belonging to the CCAAT/enhancer binding protein (C/EBP) family...
  50. pmc Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma
    Seong Hwan Park
    Laboratory of Systems Mucosal Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626 813, Korea
    J Biol Chem 285:35330-9. 2010
    ..ER stress mediators, including CCAAT enhancer-binding protein (C/EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases...
  51. pmc ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1
    You Take Oh
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
    J Biol Chem 285:41310-9. 2010
    ..Both C/EBP homologous protein (CHOP) and Elk1 are required for celecoxib-induced DR5 expression based on promoter deletion and mutation analysis and ..
  52. doi XBP1S protects cells from ER stress-induced apoptosis through Erk1/2 signaling pathway involving CHOP
    Feng Jin Guo
    Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China
    Histochem Cell Biol 138:447-60. 2012
    ..inhibition of apoptosis in response to ERS is through the Erk1/2 signaling pathway and down-regulation CHOP transcription factor. CHOP is one of the key downstream molecules known to be involved in ERS-mediated apoptosis...
  53. ncbi Isolation, characterization and chromosomal localization of the human GADD153 gene
    J S Park
    Laboratory of Molecular Genetics, National Institute on Aging, Baltimore, MD 21224
    Gene 116:259-67. 1992
    We report the isolation and characterization of the growth arrest and DNA-damage-inducible gene, GADD153, from human cells and show that it is localized in the region 12q13.1-q13.2 on chromosome 12...
  54. ncbi A systematic overview of chemotherapy effects in B-cell chronic lymphocytic leukaemia
    E Kimby
    Department of Haematology, University Hospital, Huddinge, Sweden
    Acta Oncol 40:224-30. 2001
    ..In randomised multicentre trials a benefit from fludarabine as primary therapy compared with polychemotherapy (CHOP or CAP) has been observed in terms of tolerance and treatment response but not yet in survival...
  55. ncbi Myxoid and round cell liposarcoma: a spectrum of myxoid adipocytic neoplasia
    E Orvieto
    Department of Pathology, Regional Hospital, Treviso, Italy
    Semin Diagn Pathol 18:267-73. 2001
    ..chromosome change represented most frequently by a reciprocal translocation t(12;16)(q13;p11) that fuses the CHOP gene with the TLS gene...
  56. ncbi Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function
    G Adelmant
    Departments of Molecular Biology and Radiation Oncology, Henry Ford Health System, Detroit, Michigan 48202 3450, USA
    J Biol Chem 273:15574-81. 1998
    Human translocation liposarcoma (TLS)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) is a fusion oncoprotein found specifically in a malignant tumor of adipose tissue and results from a t(12;16) translocation that fuses ..
  57. ncbi Antiemetic efficacy of ondansetron and metoclopramide, both combined with corticosteroid, in malignant lymphoma patients receiving non-cisplatin chemotherapy
    M Jørgensen
    Department of Internal Medicine, Copenhagen County Hospital Herlev, Denmark
    Acta Oncol 35:159-63. 1996
    ..A total of 109 patients with malignant lymphoma receiving their first series of non-cisplatin chemotherapy (CT) (CHOP or MOPP) were divided into prospective, randomized, open and parallel groups and analyzed at two hematological ..
  58. doi Effects of all-trans retinoic acid on sodium/iodide symporter and CCAAT/enhancer-binding protein-homologous protein under condition of endoplasmic reticulum stress in FRTL5 thyroid cells
    S J Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Republic of Korea
    Horm Metab Res 43:331-6. 2011
    ..TRANS retinoic acid (ATRA) on sodium/iodide symporter (NIS) and CCAAT/enhancer-binding protein-homologous protein (CHOP) under condition of endoplasmic reticulum (ER) stress have not been evaluated...
  59. ncbi Non-Hodgkin's lymphomas of the tonsil: a retrospective analysis of twenty-eight patients with primary tonsillary lymphoma
    I Barista
    Department of Medical Oncology, Hacettepe University, Ankara, Turkey
    Tumori 81:234-7. 1995
    ..To analyze the clinical and therapeutic aspects of patients with primary tonsillary non-Hodgkin's lymphoma...
  60. ncbi Management of non-Hodgkin lymphoma in adults in Scandinavia, United Kingdom, and The Netherlands. Report from the European School of Oncology intercity meeting at Huddinge Hospital, 3rd June, 1988
    G Juliusson
    Department of Medicine, Karolinska Institute, Huddinge Hospital, Sweden
    Acta Oncol 28:135-40. 1989
    ..The advantage of six-drug regimens over CHOP-like therapy is as yet not proven. Patients with the ability to tolerate the calculated dose have good prognosis...
  61. ncbi Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development
    E C Shugart
    Department of Biology, University of Virginia, Charlottesville 22903, USA
    Cell Growth Differ 6:1541-7. 1995
    ..Combined, the expression patterns indicate that growth arrest-associated genes are regulated by numerous signal transduction pathways throughout a discrete developmental transition...
  62. doi Arsenic trioxide sensitizes human glioma cells, but not normal astrocytes, to TRAIL-induced apoptosis via CCAAT/enhancer-binding protein homologous protein-dependent DR5 up-regulation
    Eun Hee Kim
    Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea
    Cancer Res 68:266-75. 2008
    ..Our results also indicate that an increase in CCAAT/enhancer binding protein homologous protein (CHOP) protein levels precedes As(2)O(3)-induced DR5 up-regulation...
  63. ncbi Phase III trial of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) versus cisplatin, etoposide, bleomycin and prednisone (CisEBP) for the treatment of advanced non-Hodgkin's lymphoma of high grade malignancy. The Danish Lymphoma Study Gro
    J Andersen
    Department of Oncology, Aarhus Kommunehospital, Denmark
    Acta Oncol 29:995-9. 1990
    ..The patients were randomized to 9 monthly treatment cycles of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or CisEBP (cisplatin, bleomycin, etoposide, prednisone)...
  64. doi Spotlight on rituximab in chronic lymphocytic leukemia, low-grade or follicular lymphoma, and diffuse large B-cell lymphoma†
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    BioDrugs 25:55-61. 2011
    ..lymphoma, the addition of rituximab to chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]; cyclophosphamide, vincristine, and prednisone [CVP]; mitoxantrone, chlorambucil, and prednisolone; or ..
  65. doi Rituximab: a review of its use in chronic lymphocytic leukaemia, low-grade or follicular lymphoma and diffuse large B-cell lymphoma
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:1445-76. 2010
    ..lymphoma, the addition of rituximab to chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone [CHOP], cyclophosphamide, vincristine and prednisone [CVP], mitoxantrone, chlorambucil and prednisolone, or ..
  66. ncbi [Effects of sarcoplasmic reticulum calcium ATPase 2a overexpression on endoplasmic reticulum stress in cardiomyocytes]
    Jian jun Dong
    Department of Geriatric Cardiology, General Hospital of People s Liberation Army, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 89:415-8. 2009
    ..To investigate the effects of sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) overexpression on the endoplasmic reticulum stress (ERS)...
  67. ncbi [C/EBP homologous protein-mediated endoplasmic reticulum stress-related apoptosis pathway is involved in abdominal aortic constriction-induced myocardium hypertrophy in rats.]
    Zhen Ying Zhang
    Department of Pathophysiology, Chinese PLA General Hospital, Beijing, China
    Sheng Li Xue Bao 61:161-8. 2009
    ..C/EBP homologous protein (CHOP) is a very important marker participating in ERS-associated cell apoptosis, while the role of the myocyte apoptosis ..
  68. pmc CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia
    Renata C Pereira
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT, USA
    Bone 40:619-26. 2007
    CCAAT enhancer-binding protein (C/EBP) homologous protein (CHOP), is a member of the C/EBP family of nuclear proteins and plays a role in osteoblastic and adipocytic cell differentiation...
  69. ncbi The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms
    Erinn Downs-Kelly
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 32:8-13. 2008
    ..chromosomal translocations have been identified in several myxoid sarcomas, including t(12;16)(q13;p11) FUS-DDIT3 in myxoid liposarcoma, t(7;16)(q34;p11) FUS-CREB3L2 in low-grade fibromyxoid sarcoma, and t(9;22)(q31;q12) EWSR1-..
  70. ncbi Treatment of diffuse histiocytic and diffuse mixed non-Hodgkin lymphomas with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)
    Y Cohen
    Department of Oncology, Rambam Medical Center, Faculty of Medicine, Haifa, Israel
    Acta Oncol 27:531-5. 1988
    ..non-Hodgkin lymphoma (diffuse histiocytic or diffuse mixed according to Rapport classification) were treated by the CHOP regimen (cyclophosphamide, doxorubicin, vincristine and prednisone) with a mean follow-up of 41 months...
  71. ncbi CCAAT/enhancer-binding protein-homologous protein expression and transcriptional activity are regulated by 3',5'-cyclic adenosine monophosphate in thyroid cells
    Martine Pomerance
    Unité 486, Institut National de la Santé et de la Recherche Médicale Paris XI, Faculte de Pharmacie, 5 Rue Jean Baptiste Clement, 92296 Chatenay Malabry Cedex, France
    Mol Endocrinol 17:2283-94. 2003
    ..and transcriptional activity of the p38-MAPK substrate CCAAT/enhancer-binding protein-homologous protein (CHOP). CHOP is expressed in the rat thyroid gland and in confluent PCCL3 and FRTL-5 cells...
  72. pmc CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation
    Ken Shirakawa
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Mol Cell Biol 26:6105-16. 2006
    ..Here we show that C/EBP homologous protein (CHOP; also known as C/EBPzeta) is expressed in bone as well as in mesenchymal progenitors and primary osteoblasts...
  73. ncbi Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis
    Tamara Tchkonia
    Evans Department of Medicine, Boston Univ Medical Center, 88 E Newton St, Robinson 2, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 293:E1810-9. 2007
    ..which inhibits adipogenesis, and the expression of CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), which blocks activity of adipogenic C/EBP family members, in preadipocytes cultured from young, middle-aged, and ..
  74. pmc Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis
    Takushi Namba
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Am J Pathol 174:1786-98. 2009
    ..The CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is a transcription factor that is involved in the ER stress response, especially ER stress-induced apoptosis...
  75. ncbi Stage IA non-Hodgkin's lymphoma of the Waldeyer's ring. Limited chemotherapy and radiation therapy versus radiation therapy alone
    M Uematsu
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    Acta Oncol 32:675-8. 1993
    ..received combined treatment with three cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and radiation therapy with 30 to 40 Gy. Another 9 patients were treated with radiation therapy 40 to 60 Gy alone...
  76. ncbi Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases
    C R Antonescu
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 7:3977-87. 2001
    A specific TLS-CHOP fusion gene resulting from the t(12;16) is present in at least 95% of myxoid liposarcomas (MLS)...
  77. ncbi Genistein sensitizes diffuse large cell lymphoma to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy
    Ramzi M Mohammad
    Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Cancer Ther 2:1361-8. 2003
    ..The combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) remains the standard therapy for DLCL with a cure rate of approximately 40%...
  78. ncbi Role of postoperative radiation therapy in the management of early stage primary gastric non-Hodgkin's lymphomas: a retrospective analysis
    L Cerizza
    Department of Radiotherapy, Regional Hospital of Varese, Italy
    Tumori 80:357-61. 1994
    ..of surgery and postoperative radiotherapy; chemotherapy was also administered to 10 patients, mainly with the CHOP regimen, for 4-6 cycles before radiotherapy...
  79. ncbi Combined chemoradiation for the management of nasal natural killer (NK)/T-cell lymphoma: elucidating the significance of systemic chemotherapy
    Ye Guo
    Department of Medical Oncology, Cancer Hospital of Fudan University, Shanghai, China
    Oral Oncol 44:23-30. 2008
    The objective of this analysis was to evaluate the efficacy and treatment outcome of CHOP and CHOP combined with nitrosourea chemotherapy in natural killer (NK)/T-cell lymphoma of the nasal cavity...
  80. ncbi The role of maintenance therapy in the treatment of large-cell non-Hodgkin's lymphoma
    A Aviles
    Department of Hematology, Oncology Hospital, National Medical Center, I M S S, Mexico
    Acta Oncol 30:959-62. 1991
    ..large-cell non-Hodgkin's lymphoma achieving complete restaging verified remission after induction chemotherapy (CHOP-Bleo or m-BACOD) were randomized to the following 3 arms: 1. No further treatment (observation). 2...
  81. doi Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells
    Chuanbing Zang
    Division of Oncology Hematology, Department of Hematology and Oncology, University Medicine Charité, Berlin, Germany
    Mol Cancer Ther 8:2296-307. 2009
    ..reveal that many genes implicated in endoplasmic reticulum stress signaling, such as CHOP (also known as DDIT3 or GADD153), GRP78 (HSPA5), and ATF4, are highly up-regulated, suggesting endoplasmic reticulum stress is induced...
  82. ncbi Determination of thiamine (vitamin B1) and riboflavin (vitamin B2) in meat and liver by high-performance liquid chromatography
    E Barna
    Department of Food Chemistry, National Institute of Food Hygiene and Nutrition, Budapest, Hungary
    J Chromatogr A 668:359-63. 1994
    ..Homogenized spare rib, chop, ham and liver samples were treated with acid and heated (at 121 degrees C, 30 min), followed by enzymatic ..
  83. ncbi CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability
    M Ubeda
    Massachusetts General Hospital, Howard Hughes Medical Institute, Boston, Massachusetts 02114, USA
    Biochem Biophys Res Commun 262:31-8. 1999
    The transcription factor CHOP is involved in the regulation of the cell division cycle and the control of programmed cell death in response to cellular stress. CHOP expression has been linked with several forms of cancer...
  84. pmc Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine
    Q Huang
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    Biochem J 341:225-31. 1999
    ..The regulation of gadd153 mRNA was investigated in renal proximal tubular epithelial cells (LLC-PK1) cultured in a nutrient- and serum-..
  85. doi Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age
    Rita Alaggio
    Department of Pathology, University of Padova, Padova, Italy
    Am J Surg Pathol 33:645-58. 2009
    ..Fluorescence in situ hybridization for FUS, EWSR1, CHOP (DDIT3), and MDM2 was performed in 30 cases...
  86. ncbi A novel FUS/CHOP chimera in myxoid liposarcoma
    I Panagopoulos
    Department of Clinical Genetics, Lund University Hospital, Lund, S 221 85, Sweden
    Biochem Biophys Res Commun 279:838-45. 2000
    ..The translocation results in the hybrid gene FUS/CHOP, where the central and C-terminal parts of FUS, coding for the RNA binding domain and the RGG triplet motif, are ..
  87. ncbi The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model
    R M Mohammad
    Division of Hematology and Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Clin Cancer Res 6:4950-6. 2000
    ..the original four-drug regimen introduced in the 1970s [cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)]...
  88. ncbi Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
    Pierre Pirot
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Route de Lennik, 808 CP 618, 1070 Brussels, Belgium
    Diabetes 56:1069-77. 2007
    ..endoplasmic reticulum stress-mediated cell death is the CCAAT/enhancer binding protein (C/EBP) homologous protein (Chop)...
  89. doi Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe
    Carlynn Willmore-Payne
    ARUP Laboratories, Salt Lake City, Utah, USA
    Arch Pathol Lab Med 132:952-7. 2008
    ..Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and well-differentiated liposarcomas but not lipomas...
  90. ncbi Stage I non-Hodgkin's lymphoma treated with doxorubicin-containing chemotherapy with or without radiotherapy
    K Villikka
    Department of Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 36:619-24. 1997
    ..Chemotherapy consisted of 3 or 4 cycles of M-BACOD or (bleo-)CHOP. Seventy-two (97%) of the 74 evaluable patients achieved a complete response...
  91. ncbi Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
    V Boehme
    Department of Haematology, General Hospital St Georg, Hamburg, and Institute of Medical Informatics, Statistics and Epidemiology, University Leipzig, Germany
    Ann Oncol 18:149-57. 2007
    ....
  92. ncbi Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue
    Fredrick B Hagemeister
    Department of Lymphoma Myeloma, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 429, Houston, Texas 77030, USA
    Cancer Chemother Pharmacol 49:S13-20. 2002
    ..In the private practice setting, most patients with these diseases receive CHOP or similar cyclophosphamide and doxorubicin-containing regimens at the time of initial diagnosis...
  93. ncbi Dose-response analysis for radiotherapy delivered to patients with intermediate-grade and large-cell immunoblastic lymphomas that have completely responded to CHOP-based induction chemotherapy
    R B Wilder
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Int J Radiat Oncol Biol Phys 49:17-22. 2001
    ..the dose of radiation that should be delivered to intermediate-grade and large-cell immunoblastic lymphomas that have completely responded to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)-based induction chemotherapy.
  94. doi Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60)
    Michael Pfreundschuh
    Internal Medicine, Saarland University Medical School, Saarland University, Homburg, Germany
    Lancet Oncol 9:105-16. 2008
    Cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) is used to treat patients with non-Hodgkin lymphoma...
  95. doi Prognostic significance of maximum tumour (bulk) diameter in young patients with good-prognosis diffuse large-B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: an exploratory analysis of the MabThera International Trial Group
    Michael Pfreundschuh
    Saarland University Medical School, Homburg, Germany
    Lancet Oncol 9:435-44. 2008
    ..ie, aged 18-60 years) with good-prognosis diffuse large-B-cell lymphoma (DLBCL), who have been treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone)-like chemotherapy with or without rituximab, remain ..
  96. ncbi CHOP chemotherapy of intermediate and high-grade non-Hodgkin's lymphoma
    M Llanos
    Department of Oncology, Hospital de Sant Pau, , Spain
    Acta Oncol 33:935-9. 1994
    The results of CHOP treatment in 63 patients with intermediate and high-grade non-Hodgkin's lymphoma (Working Formulation D to I), Ann Arbor stage I to IV were analyzed...
  97. pmc Induction of a secreted protein by the myxoid liposarcoma oncogene
    M Kuroda
    Skirball Institute of Biomolecular Medicine, Departments of Medicine, Cell Biology, and the Kaplan Cancer Center, New York University Medical Center, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 96:5025-30. 1999
    ..found in the majority of human myxoid liposarcomas, consists of a fusion between the transcription factor CHOP/GADD153 and the N terminus of an RNA-binding protein TLS/FUS...
  98. doi Effects of the chop lengths of alfalfa silage and oat silage on feed intake, milk production, feeding behavior, and rumen fermentation of dairy cows
    S K Bhandari
    Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 Canada
    J Dairy Sci 91:1942-58. 2008
    Effects of chop length (shorter: 6 mm, or longer: 19 mm) of alfalfa silage and oat silage were determined in 16 mid-lactation Holstein cows, 4 of which were rumen cannulated, using a replicated 4 x 4 Latin square design with a 2 x 2 ..
  99. ncbi Effects of chop length of alfalfa and corn silage on milk production and rumen fermentation of dairy cows
    S K Bhandari
    Department of Animal Science University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    J Dairy Sci 90:2355-66. 2007
    Effects of chop length (shorter = 10 mm or longer = 19 mm) of alfalfa silage and corn silage were determined in 16 midlactation Holstein cows using a 4 x 4 Latin square design with a 2 x 2 arrangement of treatments...
  100. doi HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14...
  101. doi Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma
    Jia Ruan
    Center for Lymphoma and Myeloma, Weill Cornell Medical College, 525 East 68th St, Starr 340, New York, NY 10065, USA
    J Clin Oncol 29:690-7. 2011
    ..We evaluated dose-escalated bortezomib plus standard cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus rituximab (R) in patients with diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL).

Research Grants75

  1. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
    ..therapies including: combination chemotherapy with Cyclophosphamide, Hydroxydoxorubicin, Oncovin and Prednisone (CHOP), CHOP plus Bryostatin 1 (CHOPB), Rituximab alone, Rituximab plus CHOP and radiation therapy...
  2. Trial of mesna to prevent doxorubicin-induced plasma protein oxidation and TNFa r
    Jeffrey A Moscow; Fiscal Year: 2012
    ..A/C (doxorubicin and cyclophosphamide) and non-Hodgkin lymphoma patients scheduled to receive doxorubicin in CHOP or R-CHOP regimens...
  3. Qinghua Sun; Fiscal Year: 2015
    ..tissue (brown adipose tissue) and potentiation of adipose vascular dysfunction in wild type (C57BL/6) and CHOP[CCAAT/enhancer binding protein (C/EBP) homologous protein]-/- mice in wild type and CHOP-/- mice in a whole body ..
  4. Randal J Kaufman; Fiscal Year: 2014
    ..increases expression of the proapoptotic transcription factor CAAT-enhancer binding protein homologous protein (CHOP)...
  5. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    ..myocytes and in vivo in the heart as evidenced by increased expression of GRP-78 (sensor of ER stress) and Gadd153 (a transcription factor induced by ER stress), and activation of caspase-12( a protease which plays a central ..
  6. Zhiyong Zhao; Fiscal Year: 2016
    ..UPR increases the expression of C/EBP homologous protein (CHOP), which, in turn, up-regulates pro-apoptotic factors to trigger apoptosis...
  7. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..Fifth, importance of the ER stress pathways will be substantiated using ATF6-/-, CHOP-/- and Alb-Cre-Ire11fl/fl mice fed MTP inhibitors...
  8. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..cannot be restored, the UPR causes apoptosis by up-regulating expression of the pro-apoptotic transcription factor, CHOP. These latter observations raise the alternative possibility that the UPR may contribute to the pathogenesis of ..
  9. Marina Gorbatyuk; Fiscal Year: 2014
    ..GRP78/BiP and delivery of small interfering siRNAs targeting caspase-7, caspase-12 and pro-apoptotic CHOP/GADD153 mRNAs to diminish the level of apoptosis in ADRP photoreceptors...
  10. Matthew M Lavail; Fiscal Year: 2014
    ..For example, CHOP, a transcription factor induced by the PERK branch of the UPR is sustained and promotes cell death...
  11. Makoto Miyazaki; Fiscal Year: 2016
    ..5/6 nx), and medial calcification such as DBA2/J mice with 5/6 nx and klotho knockout mice;7) ATF4 targets (CHOP and GADD34) increased in these models and 8) ATF4 regulates the expression of Pit-1, a major phosphate transporter ..
  12. Podocyte TRB in Diabetic Nephropathy
    ROBYN A CUNARD; Fiscal Year: 2012
    ..C/EBP Homologous Protein (CHOP/GADD153) expression is a hallmark of the UPR/ER stress response, and we have shown that CHOP expression is upregulated in ..
  13. Role of Ncb5or in Insulin Production
    Hao Zhu; Fiscal Year: 2010
    ..Finally, we will prepare mice homozygous for deficiencies in both NCB5OR and CHOP, a transcription factor required for ER stress induced apoptosis...
  14. Cholesterol induces oxidative stress and triggers iron and A? accumulation
    Othman Ghribi; Fiscal Year: 2012
    ..endoplasmic reticulum stress response, thereby activating the growth arrest-and DNA damage-inducible gene 153 (gadd153) and the cytokine, TNF-alpha...
  15. Role of PDX1 in insulin biosynthesis and ER homeostasis
    Cynthia Khoo; Fiscal Year: 2011
    ..To determine the effects of EROlip and GRP170 deficiency on ER homeostasis, ER stress markers such as BiP and CHOP will be measured, and Annexin V and TUNEL staining will be used to quantify [unreadable] cell apoptosis...
  16. Role of ER Stress in the Pathogenesis of Primary Open Angle Glaucoma
    GULAB ZODE; Fiscal Year: 2013
    ..insufficient UPR and impaired autophagy, TM cells induce the ER stress-initiated apoptotic transcriptional factor, Chop, which may further worsen ER homeostasis and cause TM dysfunction/loss, elevating IOP and resulting in POAG...
  17. Harmeet Malhi; Fiscal Year: 2016
    ..the cytokines monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1[unreadable]), and ii) how the CHOP branch of the UPR increases the antiinflammatory milieu in the liver by enhancing macrophage apoptosis by ..
  18. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..In the CHOP-era, it was demonstrated that survival of DLBCL patients can be predicted by measurement of expression of a limited ..
  19. WNT/BETA-CATENIN SIGNALING IN ENDOCHONDRAL OSSIFICATION
    Motomi Enomoto Iwamoto; Fiscal Year: 2009
    ..primary chondrocyte cultures, we have found that acute activation of Wnt/b-catenin signaling enhances expression of CHOP and Bip (that are key UPR response genes) and leads to apoptosis under ER stress conditions...
  20. IRA A TABAS; Fiscal Year: 2016
    ..In Aim 1, we will elucidate how mitoOS induces the ER- stress apoptosis effector CHOP;evaluate whether mitoOS pathways in addition to CHOP promote Mf apoptosis;and explore the role of 2 inducers of ..
  21. HEPATIC STEATOSIS AND ENDOPLASMIC RETICULUM STRESS IN LIVER ALLOGRAFT INJURY
    CHRISTOPHER DANIEL ANDERSON; Fiscal Year: 2012
    ..ursodeoxycholic acid (TUDCA), and by also using specific inhibition of the ER stress cell death mediator, CHOP. This represents a novel approach to CIR injury and the findings of this proposal will be leveraged rapidly into ..
  22. Yang Hu; Fiscal Year: 2016
    ..manipulating two key downstream molecules of ER stress, deleting CCAAT/enhancer binding protein homologous protein (CHOP) or activating X-box binding protein 1 (XBP-1)...
  23. HTP chemical genomic screens to identify positive regulators of the Unfolded Prot
    Randal J Kaufman; Fiscal Year: 2010
    ..an accumulation of mis-folded or poorly secreted proteins;and 2) Specific and robust activation of the PERK-eIF21-CHOP (apoptotic) arm will exacerbate the UPR and lead to cell death in malignant cells with hyper-active secretory ..
  24. Makoto Miyazaki; Fiscal Year: 2016
    ..These effects were also associated with the expression of CHOP, a transcription factor that promotes apoptosis...
  25. JULIE MARIE VOSE; Fiscal Year: 2014
    ..values of interim FLT- PET/CT and FGD-PET/CT in diffuse large B-cell lymphoma (DLBCL) patients after 2 cycles of R-CHOP chemotherapy. Our hypothesis is that FLT-PET/CT will have a substantially higher PPV when compared to FDG-PET/CT (i...
  26. Age Impaired ER Homeostasis in Wake-Active Neurons: BiP/Nox2 Crosstalk
    Nirinjini Naidoo; Fiscal Year: 2009
    ..In contrast, aged animals mount an insufficient BiP response and manifest ER dyshomeostasis with increased GADD153/CHOP...
  27. Scott R Whittemore; Fiscal Year: 2015
    ..Preliminary data demonstrate upregulation of all 3 ERSR pathways following SCI. Mice null for CHOP, a pro-apoptotic transcription factor that is downstream of PERK and activated during ERSR, showed enhanced ..
  28. Defining Neurotherapeutic Targets in Hypoxia-Induced CHOP-10 Signaling Networks
    Marc W Halterman; Fiscal Year: 2012
    ..One factor of particular Interest is the protein Chop-10 (ddit3/gadd153)...
  29. Upper Airway Nerve Injury in Apnea: BIP-CHOP-SIRT1 Crosstalk
    Sigrid C Veasey; Fiscal Year: 2013
    ..IH susceptible motoneurons accumulate a pro-apoptotic protein CHOP. Thus we suspect impaired degradation of CHOP in susceptible motoneurons contributes to their demise (Aim 2)...
  30. Scott R Whittemore; Fiscal Year: 2015
    ..Most importantly, we show that attenuation of PERK signaling in CHOP-/- (the downstream effector of PERK) mice or after i.v...
  31. Sec61 and ER Stress in Beta-cell Function and Type 2 Diabetes
    Nicholas Gekakis; Fiscal Year: 2012
    ..g. Bip), and, in the case that ER stress cannot be relieved, up regulation of the proapoptotic transcription factor Chop. Bip and Chop are both up regulated in diabetic Sec61a1 mutant animals...
  32. Raghunatha R Yammani; Fiscal Year: 2014
    ..Our preliminary studies showed that human chondrocytes treated with FFA (palmitate) express CHOP/GADD153, a molecular marker of ER stress. This suggests that FFA induces ER stress in chondrocytes...
  33. Raghu Vemuganti; Fiscal Year: 2014
    ..the effect of knocking-out/inhibiting individual rate-limiting proteins of PERK pathway eif2[unreadable], ATF4 and CHOP on oxidative stress and neuronal damage after TBI? Conversely, what is the effect of knocking-out/inhibiting NOX2 ..
  34. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..The applicant will draw on outstanding resources, including the Children's Hospital of Philadelphia (CHOP) Cancer Center, the UPENN Clinical and Translational Research Center, Center for Clinical Epidemiology and ..
  35. GLUTAMATE TRANSPORTERS IN THE CNS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2011
    ..D. University of Iowa Consultant Shelley Russek, Ph.D. Boston University Consultant John Wolfe, V.M.D./Ph.D. CHOP/University of Pennsylvania Consultant Human Embryonic Stem Cells X No CH Yes If the proposed project Involves human ..
  36. Hesham M Amin; Fiscal Year: 2015
    ..this lymphoma, and as in other types of T-cell lymphoma, the treatment of NPM-ALK+ ALCL is primarily based on the CHOP combination chemotherapy regimen...
  37. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..PCR (qPCR) and ChIP assays, we will study the recruitment of promoter specific transcription factors (XBP-1, CHOP, ATF6, ATF4, CREB, TORC3, PGC-1a), general transcription factors (Pol II, NF-Y, NFR, Sp1, TBP and p300) and ..
  38. Frank A Anania; Fiscal Year: 2016
    ..with stress transcriptional activation, and post-transcriptional modification o c-[unreadable] homologous protein (CHOP) as well as expression of key proteins associated with cell survival and apoptosis...
  39. Michelle Denburg; Fiscal Year: 2016
    ..She will draw on outstanding resources including the CHOP Research Institute and CTSA, the Center for Clinical Epidemiology and Biostatistics, and NEPTUNE...
  40. Stuart H Friess; Fiscal Year: 2014
    ..UPENN) and a Pediatric Critical Care Medicine Attending Physician at the Children's Hospital of Philadelphia (CHOP)...
  41. DECISION SUPPORT SYSTEM TO GUIDE PEDIATRIC PHARMACOTHERAPY
    JEFFREY SCOTT BARRETT; Fiscal Year: 2010
    ..Pediatric Pharmacotherapy Decision Support Systems (PPDSS) at The Children's Hospital of Philadelphia (CHOP) in an attempt to address these issues...
  42. Rachana Shah; Fiscal Year: 2015
    ..In order to complete her proposed studies, Dr Shah will have access to resources in the Penn/CHOP CTSA-sponsored Clinical and Translational Research Center (CTRC), Dr Reilly's laboratory, core facilities, and ..
  43. KELLY ANN DOUGHERTY; Fiscal Year: 2014
    ..at University of Pennsylvania (UPenn) Perelman School of Medicine and The Children's Hospital of Philadelphia (CHOP). Dr...
  44. Alexis A Topjian; Fiscal Year: 2016
    ..Care, and Pediatrics at the University of Pennsylvania (UPenn), and the Children's Hospital of Philadelphia (CHOP), is resubmitting her application for the Mentored Patient-Oriented Research Career Development Award (K23)...
  45. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..The data will provide a foundation for clarifying the underlying potential pathological mechanisms of MDD in HIV-infected individuals. ..
  46. High Resolution Peripheral Quantitative CT
    MARY BETH LEONARD; Fiscal Year: 2013
    ..Research Center (CTRC) Nutrition Assessment Core, supported by the joint Children's Hospital of Philadelphia (CHOP) - University of Pennsylvania (Penn) Clinical and Translational Science Award...
  47. Combination immunotherapy with gene modified CD4 and CD8 T cells and stem cells
    Carl H June; Fiscal Year: 2013
    ..Zinc Finger Nucleases to Specifically Disrupt HIV Coreceptor Expression (Project 3: Doms [Penn] and Perez [CHOP])...
  48. Sensimmer Virtual Phaco Trainer for Cataract Surgery
    P Pat Banerjee; Fiscal Year: 2011
    ..The trainer will be capable of simulating standard surgical techniques (e.g., phaco chop;divide and conquer) and unusual clinical cases (e.g., weak zonules)...
  49. MICHAEL BYRNE ROBINSON; Fiscal Year: 2015
    DESCRIPTION (Provided by Applicant): This IDDRC is a collaboration of the Children's Hospital of Philadelphia (CHOP) and the University of Pennsylvania (Penn)...
  50. Installation of Energy-Efficient Cage Washers for Childrens Hospital Vivarium
    Philip R Johnson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Children's Hospital of Philadelphia (CHOP) seeks to purchase and install two high- efficiency cage washers for its principal vivarium, a 32,000 gross square feet multi-species facility that ..
  51. Sara E Pinney; Fiscal Year: 2015
    ..Pennsylvania School of Medicine (PENN) and an attending physician at The Children's Hospital of Philadelphia (CHOP). This program is a natural extension of Dr...
  52. Leonard Petrucelli; Fiscal Year: 2014
    ..experiments in cells lead to enhanced sensitivity to ER stressors and increased levels of the transcription factor CHOP (C/EBP homologous protein), a protein that is induced by ER stress and promotes apoptosis...
  53. Alessandro Guidotti; Fiscal Year: 2015
    ..This proposed research is potentially a major step toward the identification of objective biomarkers capable of predicting conversion to psychosis in HRSK subjects. ..
  54. Metabolic regulation in growth factor-dependent cells
    Ralph J DeBerardinis; Fiscal Year: 2010
    ..The candidate, an Instructor in Pediatrics at The Children's Hospital of Philadelphia (CHOP), receives basic science research mentoring from Craig Thompson, MD at the University of Pennsylvania, and clinical ..
  55. Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
    WAYNE WILLIAM contact HANCOCK; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): The Children's Hospital of Philadelphia (CHOP) contributes substantially to the local economy...
  56. REGULATION OF HEPATIC INSULIN EXTRACTION
    Kenneth S Polonsky; Fiscal Year: 2013
    ..increased expression of pro-apoptotic proteins in the pancreatic beta-cell including NIX, PUMA and BIM as well as CHOP, a mediator of apoptosis in response to ER stress...
  57. The Role of DNA Demethylation by Gadd45b in Memory and Synaptic Plasticity
    FARAZ ALI SULTAN; Fiscal Year: 2013
    ..The proposed study is designed to investigate the breadth of the ethological, physiological and molecular role of DNA demethylation in further detail. ..
  58. Transition Readiness of Adolescent and Young Adult Survivors of Childhood Cancer
    Lisa Schwartz; Fiscal Year: 2012
    ..validity ratings, cognitive think aloud interviews) with PPP from The Children's Hospital of Philadelphia (CHOP) and non CHOP PPP, three TRI versions for PPP will be developed (Aim 2)...
  59. Comprehensive Clinical Decision Support for the Primary Care of Premature Infants
    Robert W Grundmeier; Fiscal Year: 2010
    ..The Children's Hospital of Philadelphia (CHOP) contributes substantially to the local economy...
  60. Effect of Aging on Preadipocyte Differentiation
    James L Kirkland; Fiscal Year: 2012
    ..increased TNF1 release by preadipocytes with aging, and stress-responsive, anti-adipogenic regulators (CUGBP, CHOP) all impede adipogenesis in old rats...
  61. Jeffrey H Silber; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): This is a proposal from the Children's Hospital of Philadelphia (CHOP) to become part of the Pediatric Quality Measures Program's (PQMP's) Centers of Excellence (CoE) network...
  62. Hamid Bassiri; Fiscal Year: 2015
    ..subspecialty fellowship training in Pediatric Infectious Diseases at the Children's Hospital of Philadelphia (CHOP), and am now expanding my scientific skills in NKT cell biology and tumor immunology, and developing my clinical ..
  63. Kale S Bongers; Fiscal Year: 2015
    ..Through these studies, we hope to identify a central pathway that drives skeletal muscle atrophy and, in doing so, identify new therapeutic targets to treat this devastating condition, which affects millions of Americans annually. ..
  64. Keshav K Singh; Fiscal Year: 2014
    ..suggest that human cells contain mitochondria specific stress response pathway in which transcription factor GADD153 (also known as CHOP or DDIT3) plays a key role...
  65. Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 (NK1-R) Antagonists
    STEVEN DANIEL DOUGLAS; Fiscal Year: 2013
    ..The investigators from the Joseph Stokes, Jr. Rl, CHOP, the UPenn Schools of Medicine (Depts. of Pediatrics, Psychiatry, &Medicine) and Westat...
  66. C/EDB BETA AND CHOP IN EPIDERMAL DIFFERENTIATION
    Edward Maytin; Fiscal Year: 2002
    ..the proposed experiments will establish, in a causal manner, how two members of the C/EBP family (C/EBPbeta and CHOP) may be critical for the proper and orderly progression of the epidermal differentiation program...
  67. Steven M Willi; Fiscal Year: 2016
    ..and is strongly supported by access to a superb range of institutional resources, including the CHOP CTRC and the UPenn DERC.
  68. Michael E Shy; Fiscal Year: 2016
    ..of Rochester/Muscle Study Group (MSG), the University of Pennsylvania/Children's Hospital of Philadelphia (CHOP), and the University of Miami, Florida. Two Pilot Projects will be performed. Dr...
  69. Mortimer Poncz; Fiscal Year: 2016
    ..Thrombocytopenia and Thrombosis in HIT under Mortimer Poncz at the Children's Hospital of Philadelphia (CHOP) will examine the events that occur in vivo that lead to both the thrombocytopenia and prothrombotic state...
  70. BRADLEY ALAN WARADY; Fiscal Year: 2016
    ..Two clinical coordinating centers (CCCs) (at the Children's Hospital of Philadelphia (CHOP), and Children's Mercy Hospital (CMH) in Kansas City), a central laboratory (at the University of Rochester), ..
  71. Susan L Furth; Fiscal Year: 2016
    ..Two clinical coordinating centers (CCCs) (at the Children's Hospital of Philadelphia (CHOP), and Children's Mercy Hospital (CMH) in Kansas City), a central laboratory (at the University of Rochester), ..
  72. Robert Michael Sutton; Fiscal Year: 2014
    ..UPenn), and Pediatric Critical Care Attending Physician at the Children's Hospital of Philadelphia (CHOP), is applying for a Mentored Patient-Oriented Research Career Development Award (K23)...
  73. High Throughput Chemical Genomic screening to identify novel ER stress-inducing
    ANDREW MICHAEL FRIBLEY; Fiscal Year: 2010
    ..We have reported that proteasome inhibition induced ER stress and C/EBP-homologous protein- (CHOP) mediated apoptosis in a variety of HNSCC cell lines, including several that are not sensitive to cisplatin...
  74. Identifying Strategies to Increase Engagement in Clinical Trials in Pediatric SCD
    Lamia P Barakat; Fiscal Year: 2010
    ..Through collaboration among The Children's Hospital of Philadelphia (CHOP), the Marian Anderson Sickle Cell Center, and community organizations, we will develop community-generated, ..
  75. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    ..It's function in the serum includes binding to phosphorylcholine (ChoP) on the cell wall of Streptococcus pneumoniae, which leads to activation of the complement pathway and promotion of ..