DDC

Summary

Gene Symbol: DDC
Description: dopa decarboxylase
Alias: AADC, aromatic-L-amino-acid decarboxylase, dopa decarboxylase (aromatic L-amino acid decarboxylase)
Species: human

Top Publications

  1. ncbi Identification of dopaminergic nerves in humans
    C Bell
    Department of Physiology, University of Melbourne Medical Centre, Parkville, Victoria, Australia
    Am J Hypertens 3:4S-6S. 1990
  2. ncbi Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis)
    S Maity
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta
    Jpn J Pharmacol 78:285-92. 1998
  3. ncbi Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder
    A D Børglum
    Institute of Human Genetics, Danish Centre for Human Genome Research, Aarhus University, Denmark
    Mol Psychiatry 4:545-51. 1999
  4. ncbi Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
  5. pmc Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1
    Shizuma Ishikawa
    Graduate School of Agriculture, Hokkaido University, Kita ku, Sapporo 060 8589, Japan
    J Biol Chem 284:28832-44. 2009
  6. ncbi Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis
    C Sumi-Ichinose
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    Biochemistry 31:2229-38. 1992
  7. ncbi Cloning and expression of human placental L-Dopa decarboxylase
    Maria Zaharenia Siaterli
    University of Athens, Department of Biochemistry and Molecular Biology, Panepistimiopolis 15701, Athens, Greece
    Neurochem Res 28:797-803. 2003
  8. ncbi Molecular detection of dopamine decarboxylase expression by means of reverse transcriptase and polymerase chain reaction in bone marrow and peripheral blood: utility as a tumor marker for neuroblastoma
    Fabio Bozzi
    Department of Medical Oncology, Division of Pediatrics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Diagn Mol Pathol 13:135-43. 2004
  9. ncbi DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
  10. ncbi Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB
    M Ribases
    Department of Psychiatry, Hospital Universitari Vall d Hebron, Barcelona, Catalonia, Spain
    Mol Psychiatry 14:71-85. 2009

Research Grants

  1. Parkinson's Disease Gene Therapy Study Group
    Howard Federoff; Fiscal Year: 2006
  2. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
  3. Nigrostriatal Dopamine Function
    JAMES TEPPER; Fiscal Year: 2009
  4. Donald M Kuhn; Fiscal Year: 2016
  5. Pedro A Jose; Fiscal Year: 2015
  6. Nucleoside Transporters In HAART Mitochondrial Toxicity
    John Buolamwini; Fiscal Year: 2006
  7. a-Synuclein and Dopamine: Implications of Parkinsonism
    Ruth G Perez; Fiscal Year: 2010
  8. Role of Tyrosine in MDMA Toxicity
    Bryan K Yamamoto; Fiscal Year: 2010
  9. Focal Dopamine Indicated in Dyskinesias in MPTP Monkeys
    Krystof S Bankiewicz; Fiscal Year: 2010
  10. Enzymatic Replacement in PD Monkeys by Gene Transfer
    Krystof Bankiewicz; Fiscal Year: 2003

Detail Information

Publications295 found, 100 shown here

  1. ncbi Identification of dopaminergic nerves in humans
    C Bell
    Department of Physiology, University of Melbourne Medical Centre, Parkville, Victoria, Australia
    Am J Hypertens 3:4S-6S. 1990
    ..neurons can be distinguished from those of noradrenergic neurons by their content of DOPA decarboxylase (DDC)...
  2. ncbi Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis)
    S Maity
    Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta
    Jpn J Pharmacol 78:285-92. 1998
    ..significantly reduced the incidence of gastric erosions and severity induced by ethanol, diethyldithiocarbamate (DDC) and diethylmaleate (DEM)...
  3. ncbi Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder
    A D Børglum
    Institute of Human Genetics, Danish Centre for Human Genome Research, Aarhus University, Denmark
    Mol Psychiatry 4:545-51. 1999
    DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin...
  4. ncbi Modulation of [18F]fluorodopa (FDOPA) kinetics in the brain of healthy volunteers after acute haloperidol challenge
    Ingo Vernaleken
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany
    Neuroimage 30:1332-9. 2006
    In animal studies, acute antipsychotic treatment was shown to enhance striatal DOPA-decarboxylase (DDC) activity. However, this phenomenon has not been demonstrated in humans by positron emission tomography (PET)...
  5. pmc Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1
    Shizuma Ishikawa
    Graduate School of Agriculture, Hokkaido University, Kita ku, Sapporo 060 8589, Japan
    J Biol Chem 284:28832-44. 2009
    ..synthesized from tyrosine by two enzymes, tyrosine hydroxylase (TH) and 4-dihydroxy-L-phenylalanine decarboxylase (DDC)...
  6. ncbi Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis
    C Sumi-Ichinose
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    Biochemistry 31:2229-38. 1992
    Aromatic L-amino acid decarboxylase (AADC) catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones ..
  7. ncbi Cloning and expression of human placental L-Dopa decarboxylase
    Maria Zaharenia Siaterli
    University of Athens, Department of Biochemistry and Molecular Biology, Panepistimiopolis 15701, Athens, Greece
    Neurochem Res 28:797-803. 2003
    L-Dopa decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-Dopa to dopamine...
  8. ncbi Molecular detection of dopamine decarboxylase expression by means of reverse transcriptase and polymerase chain reaction in bone marrow and peripheral blood: utility as a tumor marker for neuroblastoma
    Fabio Bozzi
    Department of Medical Oncology, Division of Pediatrics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Diagn Mol Pathol 13:135-43. 2004
    A highly sensitive molecular method was used to evaluate the presence of dopamine decarboxylase (DDC) mRNA in the bone marrow and peripheral blood of patients with neuroblastoma (NB)...
  9. ncbi DOPA decarboxylase gene is associated with nicotine dependence
    Heping Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Pharmacogenomics 7:1159-66. 2006
    ..Although the heritability of nicotine dependence (ND) is well documented and many candidate genetic regions have been identified, few of them were confirmed. This may be, in part, due to analytic methods that sacrifice power...
  10. ncbi Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB
    M Ribases
    Department of Psychiatry, Hospital Universitari Vall d Hebron, Barcelona, Catalonia, Spain
    Mol Psychiatry 14:71-85. 2009
    ..Several significant associations were found after correcting for multiple testing: (1) the DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0...
  11. doi Expression of enzymatically active L-DOPA decarboxylase in human peripheral leukocytes
    Ioanna Kokkinou
    Department of Biochemistry Molecular Biology, University of Athens, Athens, Greece
    Blood Cells Mol Dis 42:92-8. 2009
    L-DOPA decarboxylase (DDC) is a pyridoxal 5-phosphate (PLP)-dependent enzyme that catalyses the decarboxylation of L-DOPA to dopamine...
  12. pmc Germline genomic variants associated with childhood acute lymphoblastic leukemia
    Lisa R Treviño
    St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Genet 41:1001-5. 2009
    ..86, respectively) and were associated with methotrexate accumulation and gene expression pattern in leukemic lymphoblasts. We conclude that germline variants affect susceptibility to, and characteristics of, specific ALL subtypes...
  13. doi The U937 macrophage cell line expresses enzymatically active L-Dopa decarboxylase
    Ioanna Kokkinou
    University of Athens, Dept of Biochemistry and Molecular Biology, Panepistimiopolis 1570, Athens, Greece
    J Neuroimmunol 216:51-8. 2009
    In the present study we demonstrate that enzymatically active l-Dopa decarboxylase (DDC) is expressed in U937 cells, an important model of human macrophage function. The mRNA coding for the enzyme was found to be of the neural-type...
  14. doi Release of membrane-associated L-dopa decarboxylase from human cells
    Ioanna Chalatsa
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Zografou, 15701, Athens, Greece
    Neurochem Res 36:1426-34. 2011
    ..neural and non-neural origin, by temperature-induced phase separation in Triton X-114 resulted in the detection of DDC molecules in all separation phases...
  15. doi Molecular insights into the pathogenicity of variants associated with the aromatic amino acid decarboxylase deficiency
    Riccardo Montioli
    Dipartimento di Scienze della Vita e della Riproduzione, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Universita degli Studi di Verona, Strada Le Grazie, 8, 37134, Verona, Italy
    J Inherit Metab Dis 34:1213-24. 2011
    Dopa decarboxylase (DDC or AADC) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the decarboxylation of L-aromatic amino acids into the corresponding aromatic amines...
  16. pmc Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases
    Giorgio Giardina
    Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 108:20514-9. 2011
    ....
  17. doi L-dopa decarboxylase (DDC) gene expression is related to outcome in patients with prostate cancer
    Georgios Koutalellis
    1st Department of Urology, Laiko General Hospital, University of Athens, School of Medicine, Athens, Greece
    BJU Int 110:E267-73. 2012
    What's known on the subject? and What does the study add? L-dopa decarboxylase (DDC) has been documented as a novel co-activator of androgen receptor transcriptional activity...
  18. doi S250F variant associated with aromatic amino acid decarboxylase deficiency: molecular defects and intracellular rescue by pyridoxine
    Riccardo Montioli
    Department of Life Sciences and Reproduction, University of Verona, Verona, Italy
    Hum Mol Genet 22:1615-24. 2013
    Dopa or aromatic amino acid decarboxylase (DDC, AADC) is a pyridoxal 5'-phosphate-dependent enzyme that catalyses the production of the neurotransmitters dopamine and serotonin...
  19. doi Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Clin Biochem 41:1140-9. 2008
    L-Dopa decarboxylase (DDC) is a pyridoxal 5'-phosphate-dependent enzyme that was found to be involved in many malignancies...
  20. ncbi Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase
    H Ichinose
    Department of Biochemistry, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 164:1024-30. 1989
    ..9 kDa. The amino acid sequence Asn-Phe-Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes...
  21. pmc Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system
    Latif A Wafa
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Biochem J 375:373-83. 2003
    ..b>DDC (L-dopa decarboxylase) was detected multiple times as a novel AR-interacting protein, which was subsequently ..
  22. ncbi Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA
    Dido Vassilacopoulou
    University of Athens, Department of Biochemistry and Molecular Biology, Panepistimioupolis 15701, Athens, Greece
    Neurochem Res 29:1817-23. 2004
    L-Dopa decarboxylase (DDC) has been cloned from several species and was shown to undergo alternative splicing within its 5'-untranslated and coding regions...
  23. pmc Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma
    C K Kontos
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens GR 15701, Greece
    Br J Cancer 102:1384-90. 2010
    L-DOPA decarboxylase (DDC) is an enzyme that catalyses, mainly, the decarboxylation of L-DOPA to dopamine and was found to be involved in many malignancies...
  24. ncbi [Juvenile Parkinson's disease initially presenting as bulbar incoordination: a case report]
    K Kon
    Division of Child Neurology, National Center Hospital for Mental, Nervous, and Muscular Disorders, Tokyo
    No To Hattatsu 26:269-74. 1994
    ....
  25. ncbi Hematological effects of 2',3'-dideoxycytidine in rabbits
    J H Riley
    Department of Toxicology and Pathology, Hoffmann La Roche Inc, Nutley, New Jersey 07110
    Toxicol Pathol 20:367-75. 1992
    The antiviral nucleoside analogue 2',3'-dideoxycytidine (ddC) is a DNA chain terminator and/or inhibitor of human immunodeficiency virus (HIV) reverse transcriptase. We evaluated the effects of ddC in 36 New Zealand white rabbits...
  26. pmc Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo
    K Zu
    Department of Microbiology, University of Virginia, Charlottesville 22908, USA
    Mol Biol Cell 7:1059-73. 1996
    ..levels, aberrant internal exon skipping was induced in at least one endogenous transcript, the dopa decarboxylase (Ddc) pre-mRNA, which previously had been shown to be similarly affected by excess HRB98DE/hrp38...
  27. ncbi Defective 3,4-dihydroxyphenylalanine decarboxylation to dopamine in hydralazine-treated hypertensive patients may be pyridoxine remediable
    S Shigetomi
    , , Canada
    Am J Hypertens 6:33-40. 1993
    ..abstract truncated at 250 words)..
  28. ncbi The parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)) mediates release of l-3,4-dihydroxyphenylalanine (l-DOPA) and inhibition of l-DOPA decarboxylase in the rat striatum: a microdialysis study
    Steven B Foster
    Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019 0370, USA
    Chem Res Toxicol 16:1372-84. 2003
    ..basis of dialysate analysis using several HPLC methods and its conversion to DA by purified l-DOPA decarboxylase (DDC). Methamphetamine (30 mg/kg, i.p.) similarly caused a significant but transient rise of l-DOPA in the rat striatum...
  29. pmc Role of serotonergic neurons in the Drosophila larval response to light
    Verónica G Rodriguez Moncalvo
    Department of Biology, McMaster University, 1280 Main St, West, Hamilton, ON, L8S 4K1, Canada
    BMC Neurosci 10:66. 2009
    ..Thus, Drosophila larval photobehavior can be used to study control of locomotion...
  30. pmc Cloning and expression of pig kidney dopa decarboxylase: comparison of the naturally occurring and recombinant enzymes
    P S Moore
    Facoltà di Medicine e Chirurgiak Istituto di Chimica Biologica, Verona, Italy
    Biochem J 315:249-56. 1996
    L-Aromatic amino acid decarboxylase (dopa decarboxylase; DDC) is a pyridoxal 5'-phosphate (PLP)-dependent homodimeric enzyme that catalyses the decarboxylation of L-dopa and other L-aromatic amino acids...
  31. ncbi Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition
    J Rouru
    Department of Pharmacology and Clinical Pharmacology, Clinical Research Services Turku, University of Turku, Finland
    Eur J Clin Pharmacol 55:461-7. 1999
    ..acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the treatment of Parkinson's disease...
  32. ncbi Simultaneous quantitation of nucleoside HIV-1 reverse transcriptase inhibitors by short-end injection capillary electrochromatography on a beta-cyclodextrin-bonded silica stationary phase
    N Mesplet
    Institut de Chimie Organique et Analytique, UMR CNRS 6005, , France
    J Chromatogr A 927:161-8. 2001
    ..zidovudine (AZT), lamivudine (3TC), didanosine (ddA) and its administrated form (ddI), stavudine (d4T) and hivid (ddC). CEC on chiral stationary phase has mainly been dedicated to the separation of enantiomers...
  33. ncbi Hormonal induction of Dopa decarboxylase in the epidermis of Drosophila is mediated by the Broad-Complex
    R B Hodgetts
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Development 121:3913-22. 1995
    ..Mutations in the br subcomplementation group substantially reduce the levels of Dopa decarboxylase (DDC) in the epidermis of mature third instar larvae but not in mature second instar organisms...
  34. ncbi Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila
    Li Chen
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Mech Dev 119:145-56. 2002
    The induction of the Dopa decarboxylase gene (Ddc) in the epidermis of Drosophila at pupariation is a receptor-mediated response to the steroid molting hormone, ecdysone...
  35. pmc Three types of tyrosine hydroxylase-positive CNS neurons distinguished by dopa decarboxylase and VMAT2 co-expression
    Eberhard Weihe
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University Marburg, Marburg, Germany
    Cell Mol Neurobiol 26:659-78. 2006
    ..proteins for catecholaminergic neurotransmission tyrosine hydroxylase (TH), aromatic acid acid decarboxylase (AADC), and the brain-specific isoform of the vesicular monoamine transporter, VMAT2, using highly specific antibodies ..
  36. pmc Innate immunity in insects: surface-associated dopa decarboxylase-dependent pathways regulate phagocytosis, nodulation and melanization in medfly haemocytes
    Maria Sideri
    Laboratory of Biology, Department of Biology, University of Patras, Patras, Greece
    Immunology 123:528-37. 2008
    ..In this report, we demonstrated that these three processes appear to be also dependent on dopa decarboxylase (Ddc) activity...
  37. pmc Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model
    P Soares da Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal
    Br J Pharmacol 114:1403-13. 1995
    ....
  38. pmc Patterns of naturally occurring restriction map variation, dopa decarboxylase activity variation and linkage disequilibrium in the Ddc gene region of Drosophila melanogaster
    C F Aquadro
    Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Genetics 132:443-52. 1992
    ..from five natural populations were surveyed for restriction map variation in a 65-kb region surrounding the gene (Ddc) encoding dopa decarboxylase (DDC). Sixty-nine restriction sites were scored, 13 of which were polymorphic...
  39. ncbi Stimulation of dopa decarboxylase activity in striatum of healthy human brain secondary to NMDA receptor antagonism with a low dose of amantadine
    P Deep
    McConnell Brain Imaging Center, Montreal Neurological Institute, 3801 University St, Montreal, Quebec, Canada H3A 2B4
    Synapse 34:313-8. 1999
    ..motor symptoms of Parkinson's disease may be mediated in part by stimulation of cerebral dopa decarboxylase (DDC) activity, secondary to antagonism of N-methyl-D-aspartate (NMDA) type glutamate receptors...
  40. ncbi The coordination of the sequential appearance of MHR4 and dopa decarboxylase during the decline of the ecdysteroid titer at the end of the molt
    Kiyoshi Hiruma
    Faculty of Agriculture and Life Sciences, Hirosaki University, Hirosaki 036 8561, Japan
    Mol Cell Endocrinol 276:71-9. 2007
    ..as E75B, MHR3, MHR4, and betaFTZ-F1 appear and disappear in the abdominal epidermis leading to dopa decarboxylase (DDC) expression...
  41. ncbi Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species
    Sandra M Lelli
    Salud Humana y Medio Ambiente DIMXSA, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Ciudad Autonoma de Buenos Aires, Argentina
    Toxicology 216:49-58. 2005
    ..drug 2-allyl-2-isopropylacetamide (AIA) and with a single dose of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). Thus, rats were divided into the following groups: group L (100 mg AIA + 50 mg DDC/kg body wt...
  42. pmc Assessment of renal dopaminergic system activity during cyclosporine A administration in the rat
    M Pestana
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal
    Br J Pharmacol 115:1349-58. 1995
    ..The enhanced ability of the renal tissues of CsA-treated animals to synthesize dopamine, when exogenous L-DOPA is provided, results from an enhanced activity of the uptake process of L-DOPA in renal tubular cells...
  43. pmc From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects
    Christopher Vavricka
    Department of Biochemistry, Virginia Tech, Blacksburg, Virginia, United States of America
    PLoS ONE 6:e16124. 2011
    ..amino acid decarboxylase (AAAD) family based on extremely high sequence homology (∼70%) with dopa decarboxylase (Ddc), was biochemically investigated...
  44. ncbi Hemolysis of human red blood cells induced by the combination of diethyldithiocarbamate (DDC) and divalent metals: modulation by anaerobiosis, certain antioxidants and oxidants
    I Ginsburg
    Department of Oral Biology, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    Free Radic Res 31:79-91. 1999
    ..of the present communication is to describe the role played by combinations between diethydithiocarbamate (DDC) and divalent metals in hemolysis of human RBC...
  45. ncbi [Metabolism and vascular effects of gammaglutamyl L-dopa on the isolated kidney of the rat]
    A Caillette
    , , Lyon, France
    Arch Mal Coeur Vaiss 81:179-82. 1988
    ..At 4 X 10(-5) M, the renal response (30 +/- 3 p. 100 of the relaxation induced by 10(-4) M of papaverine) was similar to that elicited by DA at 20 fold lower concentration.(ABSTRACT TRUNCATED AT 250 WORDS)..
  46. pmc cis-regulatory sequences responsible for alternative splicing of the Drosophila dopa decarboxylase gene
    J Shen
    Biology Department, University of Virginia, Charlottesville 22903
    Mol Cell Biol 14:7385-93. 1994
    The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in specific sets of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues...
  47. ncbi On the evolution of Dopa decarboxylase (Ddc) and Drosophila systematics
    A Tatarenkov
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697 2525, USA
    J Mol Evol 48:445-62. 1999
    We have sequenced most of the coding region of the gene Dopa decarboxylase (Ddc) in 24 fruitfly species. The Ddc gene is quite informative about Drosophila phylogeny...
  48. pmc Overexpression of dopa decarboxylase in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastases with real-time RT-PCR
    C Sakakura
    Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Kamigyo ku, Kawaramachi dori, Kyoto 602 8566, Japan
    Br J Cancer 90:665-71. 2004
    ..One of the upregulated genes is dopa decarboxylase (DDC), which is responsible for the synthesis of the key neurotransmitters dopamine and serotonine...
  49. ncbi Biphasic effect of androgens on prostate cancer cells and its correlation with androgen receptor coactivator dopa decarboxylase
    Chen Shao
    Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    J Androl 28:804-12. 2007
    ..the dual effect of androgen on prostate cancer cells and further explore its correlation with dopa decarboxylase (DDC), an androgen receptor (AR) coactivator and a traditional neuroendocrine differentiation (NED) marker...
  50. ncbi The orphan nuclear receptor DHR38 influences transcription of the DOPA decarboxylase gene in epidermal and neural tissues of Drosophila melanogaster
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Genome 50:1049-60. 2007
    The DOPA decarboxylase gene (Ddc) belongs to the "early-late" class of ecdysone-inducible genes in Drosophila melanogaster...
  51. doi Insights into the mechanism of oxidative deamination catalyzed by DOPA decarboxylase
    Mariarita Bertoldi
    Dipartimento di Scienze Morfologico Biomediche, Sezione di Chimica Biologica, Facolta di Medicina e Chirurgia, Strada Le Grazie, 8, 37134 Verona, Italy
    Biochemistry 47:7187-95. 2008
    ..oxidative deamination reaction catalyzed by the pyridoxal 5'-phosphate (PLP) enzyme DOPA decarboxylase (DDC) was here investigated...
  52. ncbi A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster
    Monica M Davis
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Development 134:4395-404. 2007
    ..Together, two enzymes, tyrosine hydroxylase (TH, encoded by ple) and dopa decarboxylase (DDC, encoded by Ddc), produce the dopamine that is required for tanning...
  53. ncbi Regulation of the Drosophila dopa decarboxylase gene in neuronal and glial cells
    C J Beall
    Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 1:510-20. 1987
    A cis-regulatory element selectively required for the Drosophila melanogaster dopa decarboxylase gene (Ddc) in the central nervous system has been identified previously (Scholnick et al. 1986)...
  54. pmc Kinetic isotope effects of L-Dopa decarboxylase
    Yen Lin Lin
    Department of Chemistry, Digital Technology Center and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 133:4398-403. 2011
    ..isotope effects (KIEs) in the amino acid decarboxylation of L-Dopa catalyzed by the enzyme L-Dopa decarboxylase (DDC) along with the corresponding uncatalyzed reaction in water. DDC is a pyridoxal 5'-phosphate (PLP) dependent enzyme...
  55. ncbi Significance of human striatal D-neurons: implications in neuropsychiatric functions
    Keiko Ikemoto
    Clinical Research Institute, National Minami Hanamaki Hospital, 500 Suwa, Hanamaki, Iwate, 025 0033, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 28:429-34. 2004
    ..ventral part, the nucleus accumbens (Acc), contains numerous nonmonoaminergic aromatic L-amino acid decarboxylase (AADC) [=dopa decarboxylase (DDC)] neurons (D-neurons)...
  56. pmc Function and evolution of the serotonin-synthetic bas-1 gene and other aromatic amino acid decarboxylase genes in Caenorhabditis
    Emily E Hare
    Department of Biology, University of San Diego, CA 92110, USA
    BMC Evol Biol 4:24. 2004
    Aromatic L-amino acid decarboxylase (AADC) enzymes catalyze the synthesis of biogenic amines, including the neurotransmitters serotonin and dopamine, throughout the animal kingdom...
  57. pmc Tissue-specific alternative splicing of the Drosophila dopa decarboxylase gene is affected by heat shock
    J Shen
    Department of Biology, University of Virginia, Charlottesville 22903
    Mol Cell Biol 13:4549-55. 1993
    The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in a small number of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues...
  58. doi Differential immunodetection of L-DOPA decarboxylase and tyrosine hydroxylase in the vertebrate retina
    Rosilane Taveira da Silva
    Programa de Pós Graduação em Ciências Biológicas Biofísica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Int J Dev Neurosci 27:469-76. 2009
    The immunocytochemical staining of L-DOPA decarboxylase (DDC) and tyrosine hydroxylase (TH) in cells of the developing avian retina and in cells of the retina of adult rats and opossum were compared...
  59. ncbi Identification of a sequence motif upstream of the Drosophila dopa decarboxylase gene that enhances heterologous gene expression
    R B Hodgetts
    Department of Genetics, University of Alberta, Edmonton, Canada
    Genome 37:526-34. 1994
    ..the role that element S, a DNA sequence motif found approximately 215 bp upstream of the Dopa decarboxylase (Ddc) gene, might play in regulating Ddc expression...
  60. ncbi Molecular epidemiology of rabies epizootics in Texas
    R E Rohde
    Texas Department of Health Zoonosis Control Division, Austin 78756, USA
    Clin Diagn Virol 8:209-17. 1997
    ..The domestic dog/coyote (DDC) and grey for (TF) rabies virus variants cannot be differentiated by antigenic typing with currently available ..
  61. ncbi A new nuclear gene for insect phylogenetics: dopa decarboxylase is informative of relationships within Heliothinae (Lepidoptera: Noctuidae)
    Q Q Fang
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Syst Biol 46:269-83. 1997
    ..report, we describe the first phylogenetic application of the sequence that encodes the enzyme dopa decarboxylase (DDC)...
  62. ncbi Nucleotide variation at the dopa decarboxylase (Ddc) gene in natural populations of Drosophila melanogaster
    Andrey Tatarenkov
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    J Genet 86:125-37. 2007
    We studied nucleotide sequence variation at the gene coding for dopa decarboxylase (Ddc) in seven populations of Drosophila melanogaster...
  63. doi L-Dopa decarboxylase expression profile in human cancer cells
    Ioanna Chalatsa
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Zografou, 15701, Athens, Greece
    Mol Biol Rep 38:1005-11. 2011
    L-Dopa decarboxylase (DDC) catalyses the decarboxylation of L-Dopa...
  64. ncbi Serotonin synthesis and distribution in Drosophila dopa decarboxylase genetic mosaics
    A M Valles
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Neurosci 10:3646-52. 1990
    In Drosophila, the enzyme dopa decarboxylase (DDC) catalyzes the last step in the biosynthesis of serotonin (5HT) and dopamine...
  65. ncbi Overlapping transcription units in Drosophila: sequence and structure of the Cs gene
    D D Eveleth
    Developmental Biology Center, University of California, Irvine 92717
    Mol Gen Genet 209:290-8. 1987
    The Cs gene lies between the functionally and evolutionarily related dopa decarboxylase (Ddc) and l(2)amd loci of Drosophila...
  66. pmc Targeted transposition at the vestigial locus of Drosophila melanogaster
    T R Heslip
    Department of Genetics, University of Alberta, Edmonton, Canada
    Genetics 138:1127-35. 1994
    ..are exploiting this unique property of P elements to study the complex regulatory domain of the Dopa decarboxylase (Ddc) gene in Drosophila melanogaster...
  67. ncbi Comprehensive expression analysis of L-dopa decarboxylase and established neuroendocrine markers in neoadjuvant hormone-treated versus varying Gleason grade prostate tumors
    Latif A Wafa
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    Hum Pathol 38:161-70. 2007
    ..L-Dopa decarboxylase (DDC), a catecholamine synthesis enzyme and androgen receptor (AR) coregulator protein, was identified as an additional ..
  68. ncbi Insect cytokine, growth-blocking peptide, is a primary regulator of melanin-synthesis enzymes in armyworm larval cuticle
    Yosuke Ninomiya
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    FEBS J 274:1768-77. 2007
    ..We have previously shown that 3,4-dihydroxy-L-phenylalanine (Dopa) decarboxylase (DDC) is activated during the molt period by preferential enhancement of its transcription in the epidermal cells ..
  69. doi Insect cytokine growth-blocking peptide signaling cascades regulate two separate groups of target genes
    Yosuke Ninomiya
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan
    FEBS J 275:894-902. 2008
    ..14.16.2) and 3,4-dihydroxy-l-phenylalanine (Dopa) decarboxylase (DDC, EC 4.1.1.26) genes, which elevate dopamine levels in insect epidermal cells...
  70. ncbi Molecular cloning of guinea-pig aromatic-L-amino acid decarboxylase cDNA
    M Taketoshi
    Department of Pharmacology II, Osaka University, Faculty of Medicine, Japan
    Biochem Biophys Res Commun 170:1229-35. 1990
    Guinea-pig aromatic-L-amino acid decarboxylase (DOPA decarboxylase, DDC), but not rat DDC, reacts with the antibody against rat histidine decarboxylase (HDC)...
  71. ncbi DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed
    Megan P Hitchins
    Department of Fetal and Maternal Medicine, Institute of Reproductive and Developmental Biology, Imperial College, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mamm Genome 13:686-91. 2002
    ..genes tend to be grouped in clusters, we investigated the imprinting status of the dopa-decarboxylase gene (DDC) and the Cordon-bleu gene (COBL) which flank GRB10 within the 7p11.2-p13 SRS duplicated region...
  72. pmc Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral corr
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, West Roxbury, MA 02132, USA
    Hum Gene Ther 15:1177-96. 2004
    ..CH I) is the rate-limiting enzyme in the biosynthesis of the cofactor for TH, aromatic amino acid decarboxylase (AADC) converts L-DOPA to dopamine, and a vesicular monoamine transporter (VMAT-2) transports dopamine into synaptic ..
  73. doi Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina
    Regina C C Kubrusly
    Instituto de Biofisica Carlos Chagas Filho, UFRJ, Brazil
    Neurochem Int 53:63-70. 2008
    ..Müller cells purified from developing chick and mouse retinas express L-DOPA decarboxylase (DDC; aromatic-L-amino-acid decarboxylase; EC 4.1.1.28) and the dopamine transporter DAT...
  74. doi [Synthesis of monoamines by non-monoaminergic neurons: illusion or reality?]
    Mikhail V Ugrumov
    Institut de Biologie du Développement, Académie Russe des Sciences et Institut de Physiologie Normale, Académie Russe des Sciences Médicales, 26 rue Vavilov, 117808 Moscou, Russie
    J Soc Biol 203:75-85. 2009
    ..one of the enzymes for dopamine (DA) synthesis, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC)...
  75. ncbi A neuron-specific enhancer of the Drosophila dopa decarboxylase gene
    W A Johnson
    Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, Massachusetts 02115
    Genes Dev 3:676-86. 1989
    ..are necessary for correct neuron-specific expression of the Drosophila melanogaster dopa decarboxylase gene, Ddc. In addition to a previously described proximal element located approximately 60 bp upstream of the mRNA start site,..
  76. ncbi [Antiretroviral treatment. Present and future of the combinations]
    J M Gatell Artigas
    Facultad de Medicina, Universidad de Barcelona, ,
    Rev Neurol 24:1627-31. 1996
    ..In Spain zidovudine (AZT), didanosine (ddl) and zacitabine (ddC) are currently available. Recent multicentric trials have shown: 1...
  77. pmc Cell inward transport of L-DOPA and 3-O-methyl-L-DOPA in rat renal tubules
    P Soares da Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal
    Br J Pharmacol 112:611-5. 1994
    ..It is further shown that 3-OMDOPA neither undergoes decarboxylation into 3-MT nor affects the decarboxylation of L-DOPA...
  78. ncbi Technetium-99m diethyldithiocarbamate (DDC): comparison with thallium-201 DDC as an agent for brain imaging
    J R Ballinger
    Division of Nuclear Medicine, Ottawa Civic Hospital, Canada
    Int J Rad Appl Instrum A 38:665-8. 1987
    Technetium-99m diethyldithiocarbamate (99mTc-DDC) was prepared by reduction of [99mTc]pertechnetate with formamidine sulfinic acid in the presence of DDC at alkaline pH, both from extemporaneous solutions and in a kit formulation...
  79. ncbi The significance of L-amino acid decarboxylase and DARPP-32 in the kidney
    A Aperia
    Department of Pediatrics, , Stockholm, Sweden
    Am J Hypertens 3:11S-13S. 1990
    ..The enzyme L-amino acid decarboxylase (L-AADC) that converts L-dopa to DA has been localized to the proximal tubule cells with immunocytochemistry...
  80. ncbi Dopamine in the developing kidney
    J Svennilson
    Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden
    Int J Dev Biol 43:441-3. 1999
    ..Here, we discuss the age-dependent distribution and some functional aspects of several parts of the renal dopamine system (dopamine, AADC, COMT, D1 receptor, and DARPP-32) during renal morphogenesis.
  81. ncbi The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes
    T Hendricks
    Case Western Reserve University, Department of Neurosciences, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 19:10348-56. 1999
    ..Together, our findings establish Pet-1 as an early and precise marker of 5-HT neurons and suggest that it functions specifically in the differentiation and maintenance of these neurons...
  82. ncbi A randomized trial of interferon alpha therapy for HIV type 1 infection
    D W Haas
    Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA
    AIDS Res Hum Retroviruses 16:183-90. 2000
    ..efficacy and safety of interferon a (IFN-alpha) administered in combination with zidovudine (ZDV) and zalcitabine (ddC) was evaluated in HIV-infected subjects with CD4+ cell counts between 300 and 500 cells/ml and no more than 14 ..
  83. ncbi Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain
    I Nagatsu
    Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    J Neural Transm (Vienna) 106:607-17. 1999
    ..In these regions, almost all the cells also show immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step enzyme for catecholamine synthesis, indicating that these neurons are catecholaminergic...
  84. ncbi Degeneration of dopaminergic neurons triggers an expression of individual enzymes of dopamine synthesis in non-dopaminergic neurons of the arcuate nucleus in adult rats
    P V Ershov
    Laboratory of Neurohistology, Institute of Normal Physiology, Russian Academy of Medical Sciences, 8 Baltiiskaya St, Moscow, Russia
    J Chem Neuroanat 30:27-33. 2005
    ..neurons and monoenzymatic neurons expressing tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC) were detected with a double-immunofluorescent technique on cryostat sections...
  85. ncbi The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
    J Jankovic
    Department of Neurology, Parkinson Disease Research Lab, Baylor College of Medicine, Houston, TX 77030, USA
    Prog Neurobiol 77:128-38. 2005
    ..dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and l-aromatic amino acid decarboxylase (AADC), all of which are important in the synthesis and storage of dopamine...
  86. pmc Keratin 8 overexpression promotes mouse Mallory body formation
    Ikuo Nakamichi
    Department of Medicine, Stanford University, and Veterans Affairs Palo Alto Health Care System, CA 94305, USA
    J Cell Biol 171:931-7. 2005
    ..MBs were induced by feeding 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)...
  87. ncbi Idle emissions from heavy-duty diesel vehicles: review and recent data
    A B M S Khan
    Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV, USA
    J Air Waste Manag Assoc 56:1404-19. 2006
    ..Six Detroit Diesel Corp. (DDC) Series 60 engines in engine test cell were found to emit less CO, NOx, and PM emissions and consumed fuel at only ..
  88. ncbi Evaluation of anti-Fas ligand-induced apoptosis and neural differentiation of PC12 cells treated with nerve growth factor using small interfering RNA method and sampling by microdialysis
    Shih Hwa Chiou
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 112, Taiwan
    Anal Biochem 363:46-57. 2007
    ..with the up-regulated messenger RNA (mRNA) expressions of tyrosine hydroxylase (TH), aromatic acid decarboxylase (AADC), and Bcl-2 by RT-PCR...
  89. ncbi [Gene therapy for Parkinson's disease]
    Shin Ichi Muramatsu
    Division of Neurology, Department of Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi, Japan
    Brain Nerve 59:425-30. 2007
    ..One trial involves gene transfer of aromatic L-amino acid decarboxylase (AADC), an enzyme that converts L-dopa to dopamine, to restore therapeutic windows of orally administered L-dopa in ..
  90. pmc Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota Medical School Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Antimicrob Agents Chemother 51:2531-9. 2007
    ..7 and 13.4 microg/ml), didanosine (ddI) (10 and 50 microM; 2.4 and 11.8 microg/ml), and zalcitabine (ddC) (1 and 5 microM; 0.21 and 1...
  91. pmc Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors
    Kaleb C Lund
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota Medical School Duluth, 1035 University Drive, Duluth, MN 55812, USA
    Toxicol Appl Pharmacol 226:94-106. 2008
    ..that 3'-azido-3'-deoxythymidine (AZT; 10 and 50 microM), AZT monophosphate (150 microM), and 2',3'-dideoxycytidine (ddC; 1 microM) prevented the phosphorylation of the NDUFB11 subunit of complex I...
  92. pmc Absence of autoantibodies connected to autoimmune polyendocrine syndrome type I and II and Addison's disease in girls and women with Turner syndrome
    Annika E Stenberg
    Dept of Otorhinolaryngology, Karolinska University Hospital, Solna, Sweden
    J Negat Results Biomed 6:10. 2007
    ....
  93. ncbi The Phox2 pathway is differentially expressed in neuroblastoma tumors, but no mutations were found in the candidate tumor suppressor gene PHOX2A
    Annica Wilzén
    Department of Clinical Genetics, Gothenburg University, S 416 85 Gothenburg, Sweden
    Int J Oncol 34:697-705. 2009
    ..microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower ..
  94. doi Hypoxia inducible factor (HIF)-2 alpha is required for the development of the catecholaminergic phenotype of sympathoadrenal cells
    Stephen T Brown
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 110:622-30. 2009
    ..This was correlated with a marked reduction in the expression of DOPA decarboxylase (DDC) and dopamine beta hydroxylase (DbetaH) but not TH...
  95. ncbi ["Squalenoylation": a new approach to the design of anticancer and antiviral nanomedicines]
    Patrick Couvreur
    Universite Paris Sud, 5, rue Jean Baptiste Clement, 92296 Chatenay Malabry
    Bull Acad Natl Med 193:663-73; discussion 673-4. 2009
    Some nucleoside analogs display significant activity against malignancies (gemcitabine, cytarabine) or viruses (ddl, ddC, AZT) by interfering with DNA synthesis...
  96. doi Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states
    George F G Allen
    Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1N 3BG, UK
    J Neurochem 114:87-96. 2010
    ..These findings suggest that maintaining adequate pyridoxal 5'-phosphate availability may be important for optimal treatment of aromatic l-amino acid decarboxylase deficiency and l-dopa-responsive conditions...
  97. pmc Microdialysis with radiometric monitoring of L-[β-11C]DOPA to assess dopaminergic metabolism: effect of inhibitors of L-amino acid decarboxylase, monoamine oxidase, and catechol-O-methyltransferase on rat striatal dialysate
    Maki Okada
    Molecular Probe Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 31:124-31. 2011
    ..dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine metabolism is regulated by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT)...
  98. doi A brief history of levodopa
    Oleh Hornykiewicz
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    J Neurol 257:S249-52. 2010
    ..Today, the concept of DA replacement with levodopa is uncontested, with levodopa being the "gold standard" of modern drug treatment of PD...
  99. doi Synthesis of 2',3'-dideoxynucleoside phosphoesters using H-phosphonate chemistry on soluble polymer support
    Céline Crauste
    UMR CNRS UM1 UM2, IBMM, University Montpellier, France
    J Org Chem 76:997-1000. 2011
    Phosphorylation of ddC and 3TC was efficiently performed on soluble poly(ethylene glycol) support. The corresponding 5'-monophosphate derivatives were obtained by oxidation of the support bound 5'-H-phosphonate intermediates...
  100. pmc Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation
    Natasha T Snider
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 195:217-29. 2011
    ..In mice, these features are induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in a strain-dependent manner, with the C57BL and C3H strains showing high and low susceptibility, respectively...
  101. doi Preimplantation and prenatal genetic diagnosis of aromatic L-amino acid decarboxylase deficiency with an amplification refractory mutation system-quantitative polymerase chain reaction
    Shou Jen Kuo
    Department of Genomic Medicine, Changhua Christian Hospital, Changhua, Taiwan
    Taiwan J Obstet Gynecol 50:468-73. 2011
    To develop a diagnostic platform for preimplantation genetic diagnosis (PGD) and prenatal genetic diagnosis (PND) to prevent births of aromatic L-amino acid decarboxylase deficiency (AADC) patients.

Research Grants67

  1. Parkinson's Disease Gene Therapy Study Group
    Howard Federoff; Fiscal Year: 2006
    ..and Kordower) Will comprehensively evaluate two vector platforms (rHIV and rAAV), each transducing the identical AADC gene cassette in the standardized non-human primate model. Project II...
  2. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
  3. Nigrostriatal Dopamine Function
    JAMES TEPPER; Fiscal Year: 2009
    ..following experimental DA denervation, and some of them have been shown to express L-amino acid decarboxylase (AADC) and the vesicular monoamine transporter (VMAT)...
  4. Donald M Kuhn; Fiscal Year: 2016
    ..L-DOPA enters the brain and is converted to DA by the ubiquitous L-aromatic amino acid decarboxylase (L-AADC)...
  5. Pedro A Jose; Fiscal Year: 2015
    ..aided by our new technique that allows selective knockdown of Gast to decrease renal Na+ or dopamine decarboxylase (Ddc) which forms L-DOPA, the immediate precursor of dopamine synthesis, in the stomach and duodenum by the infusion of ..
  6. Nucleoside Transporters In HAART Mitochondrial Toxicity
    John Buolamwini; Fiscal Year: 2006
    ..These nucleoside drugs, including zidovudine (AZT), stavudine (d4T), didanosine (DDI), zalcitabine (DDC) and lamivudine (3TC) are believed to cause mitochondria! depletion to varying extents, leading to cell death and ..
  7. a-Synuclein and Dopamine: Implications of Parkinsonism
    Ruth G Perez; Fiscal Year: 2010
    ..by reducing the activity of the second enzyme in the DA biosynthetic pathway, aromatic amino acid decarboxylase (AADC). Short term regulation of TH and AADC activity is mediated by changes in protein phosphorylation/dephosphorylation...
  8. Role of Tyrosine in MDMA Toxicity
    Bryan K Yamamoto; Fiscal Year: 2010
    ..Aromatic amino acid decarboxylase (AADC), within the 5-HT terminal then would decarboxylate DOPA to DA, leading to an accumulation of DA and consequently, ..
  9. Focal Dopamine Indicated in Dyskinesias in MPTP Monkeys
    Krystof S Bankiewicz; Fiscal Year: 2010
    ..Transduced with an AAV containing the cDNA for aromatic L- amino acid decarboxylase (AADC), striatal neurons gain the ability to produce dopamine (DA) from exogenous L-Dopa, a DA precursor...
  10. Enzymatic Replacement in PD Monkeys by Gene Transfer
    Krystof Bankiewicz; Fiscal Year: 2003
    ..We demonstrated that, by using an approach which combines the aromatic L-amino acid decarboxylase (AADC) gene and the pro-drug (L-dopa), the neurotransmitter involved in PD (dopamine) can be synthesized and regulated...
  11. Jerry L Nadler; Fiscal Year: 2016
    ..in Stat -4-/- Ldlr-/- mice fed a diabetogenic diet (DD) to induce IR and DD with additional cholesterol (DDC) to induce atherosclerosis and AT inflammation. Aim 2...
  12. ADRENAL CATECHOLAMINE SECRETION
    ROBERT PERLMAN; Fiscal Year: 1980
    ..Finally, we will investigate the extent to which catecholamine secretion and catecholamine synthesis are co-ordinately regulated...
  13. Mitochondrial Nucleotide Carriers of NRTI Metabolites
    Tod Gulick; Fiscal Year: 2007
    ..We have shown that purified OMC27 and its yeast ortholog transport NRTI-P's AZT-TP and -DP, ddl-TP, and ddC-TP in proteoliposome radiochemical flux assays...
  14. Yuko Nakajima; Fiscal Year: 2014
    ..The DNA Damage Checkpoint (DDC) triggers G2/M arrest when DNA is damaged after replication, and the maintenance of this arrest requires the ..
  15. Identifying mechanisms of liver stem cell proliferation and differentiation
    CARL BARTH ROUNTREE; Fiscal Year: 2010
    ..complementary models of liver injury: 1) chronic oxidative stress (MAT1a KO), 2) environmentally-induced damage (DDC 0.1% diet), and 3) a tissue specific induced regulatory knockout (Pten liver KO)...
  16. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..results in the activation of spinal glia and the pain-related behavior;3) systemic 2',3'-dideoxycytidine (ddC), a principal component of HAART increases CXCR4 and its cognate ligand (SDF-1) in DRG in vivo and induces ..
  17. Liver Injury and Repopulation by Bone Marrow Stem Cells
    EUGENE SCOTT SWENSON; Fiscal Year: 2010
    ..This model will be compared with experimental liver injuries induced by either the dietary toxin, DDC, or focal liver irradiation...
  18. University of New Mexico Health Sciences Center Animal Resource Facility Improvem
    KEVIN C O'HAIR; Fiscal Year: 2012
    ..Those renovations upgraded mechanical (HVAC with DDC controls and environmental alarms), floors, finishes and roofing...
  19. Gene Expression of Neuroblastoma and Normal Cells in Bone Marrow Predicts Outcome
    ROBERT CHARLES SEEGER; Fiscal Year: 2012
    ..This assay quantifies expression of CHGA, DCX, DDC, PHOX2B, and TH so that one tumor cell among 106 normal bone marrow or blood mononuclear cells can be identified...
  20. Evan S Deneris; Fiscal Year: 2015
    ..example, although our previous studies have shown that Pet-1 is needed for the coordinate induction of genes (Tph2, AADC, Sert, Vmat2, Htr1A, Htr1B, MaoB) directly responsible for 5-HT synthesis, reuptake, autoinhibition and metabolism ..
  21. MECHANISMS OF SELECTIVE ACTIONS OF ANTIVIRAL AGENTS
    Ram Agarwal; Fiscal Year: 2003
    ..During the previous grant period dideoxycytidine (ddC) and arabinosyl-cytosine (araC) resistant H9-ddC and H9-araC subclones were generated which had reduced ..
  22. LEUKOTRIENE SUBSTANCE P INTERACTIONS IN THE AIRWAYS
    EUNICE BLOOMQUIST; Fiscal Year: 1993
    ..Dietheyldithiocarbamate (DDC) is an inhibitor of this amidation reaction, and has been shown to produce differential increases in precursor, SP-..
  23. ODC AS A THERAPEUTIC TARGET--GENE FUNCTION ANALYSIS
    Gordon Luk; Fiscal Year: 1992
    The project seeks to define the regulation of ornithine decarboxylase (DDC), a potential therapeutic target for neoplasia, at the level of gene expression...
  24. Hashem B El-Serag; Fiscal Year: 2016
    ..Research Core Centers, requesting continued funding of the Texas Medical Center Digestive Diseases Center (called DDC for simplicity)...
  25. Medical Management of Pediatric Neurotransmitter Disorders- A Multidisciplinary
    K Michael Gibson; Fiscal Year: 2007
    ..date and those that will be discussed at this conference include: aromatic L- amino acid decarboxylase deficiency (AADC), guanosine triphosphate cyclohydrolase deficiency (Segawa's disease or DOPA-responsive dystonia, GTPCH), ..
  26. MECHANISMS OF NEURONAL DEATH AND NEUROPROTECTION
    ANTHONY JOHN WINDEBANK; Fiscal Year: 2010
    ..We will use the mitochondrial DNA synthesis inhibitor dideoxycytidine (ddC) to determine whether inhibition of mitochondrial DNA replication is independently sufficient to cause cell death...
  27. INTERACTIONS BETWEEN ALPHA-SYNUCLEIN/METALS/PESTICIDES
    Donato Di Monte; Fiscal Year: 2003
    ..is dramatically enhanced in the presence of either aluminum or the fungicide diethyldithiocarbamate (DDC)...
  28. STRUCTURAL STUDIES OF A GROUP OF ACYLTRANSFERASES
    Donghai Wu; Fiscal Year: 2000
    ..in a severe dose-limiting axonal peripheral neuropathy caused by several antiretroviral agents such as ddl, ddC and d4T...
  29. MECHANISMS OF RESISTANCE IN CLINICAL ISOLATES OF HIV
    Douglas Richman; Fiscal Year: 1993
    ..related compound, 3'-azido, 3'deoxyuridine (AZdU), but not to the other antiretroviral compounds, dideoxycytidine (ddC), didehydrodideoxythymidine (d4T), carbovir or foscarnet (PFA)...
  30. COMBINATION THERAPY OF HIV INFECTION
    David Parenti; Fiscal Year: 1992
    ..We would also continue to design and implement 2 or 3 drug combination pilot trails using these and other promising drugs such as ddc, and IL-2.
  31. NUCLEOSIDES WITH DUAL ANTIHIV AND HBV ACTIVITY
    RAYMOND SCHINAZI; Fiscal Year: 1999
    ..pattern, D-D4FC will be evaluated in double and triple combinations with AZT, 3TC, (-)-FTC, d4T, ddI, ddC, a protease inhibitor such as indinavir, and a nonnucleoside reverse transcriptase inhibitor, such as nevirapine...
  32. ANTIVIRAL RESISTANCE IN AIDS
    Douglas Richman; Fiscal Year: 2004
    ..Three nucleoside analogs (zidovudine [AZT], dideoxyinosine [ddI], and dideoxycytosine [ddC]) have been approved for use in the United States...
  33. Alemtuzumab treatment of steroid-refractory acute GvHD
    James Young; Fiscal Year: 2005
    ..Monocyte-derived DCs (moDCs) express CD52, whereas Langerhans cells (LCs) and dermalinterstitial DCs (DDC-IDCs) never express this epitope, either as resident populations in normal or inflamed tissue, or as cytokine ..
  34. IMMUNOLOGIC AIRWAY DISEASE CLINICAL AND BASIC STUDIES
    Roy Patterson; Fiscal Year: 1992
    The AADC at Northwestern University is an expanding program which now is composed of the Sections of Allergy-immunology' Occupational Medicine and Pulmonary Medicine of the Department of Medicine and the Division of Allergy of the ..
  35. NEUROTOXICITY OF METAL CHELATES
    Bernard Weiss; Fiscal Year: 1990
    ..be exposed to lead, nickel, and thallium in drinking water and treated twice weekly with diethyldithiocarbamate (DDC)...
  36. BORADEOXYRIBONUCLEOSIDES
    DONALD MATTESON; Fiscal Year: 1992
    ..These bear a close structural analogy to known anti-HIV-1 agents such as AZT or DDC and would be likely to decouple the crucial enzymatic phosphorylation for nucleotide synthesis...
  37. Chromium Genotoxicity: Response and Repair Mechanisms
    Steven Patierno; Fiscal Year: 2007
    ..have escaped cell death, We made the initial discovery that chromium-induced DNA-DNA interstrand crosslinks (Cr-DDC) are present in chromate-exposed cells and cause guanine-specific polymerase arrest (PAL) in in vitro replication ..
  38. OXIDATION OF SUPEROXIDE DISMUTASE:ROLE IN RED CELL AGING
    SANDRA JEWETT; Fiscal Year: 1991
    ..shown to lose activity and increase in electrophoretic heterogeneity and sensitivity to the inhibitors cyanide and DDC. The chemical events leading to these changes in the dismutase and their contribution to red cell aging have not ..
  39. AIDS: AZT TOXICITY AND MITOCHONDRIAL DNA REPLICATION
    MELVIN SIMPSON; Fiscal Year: 1993
    ..Nevertheless, many ddn's are toxic, inducing anemia (AZT), peripheral neuropathy (ddC, d4T, ddI) and pancreatitis (ddI)...
  40. ONTOGENY AND GENETIC CONTROL OF ENZYME ACTIVITY
    Theodore Wright; Fiscal Year: 1991
    ..rapidly accumulating molecular biology, the dense cluster of functionally-related genes in the DOPA deccarboxylase (Ddc) region (2-53...
  41. HIV, CYTOKINES AND THERAPEUTIC RESULT IN AIDS LYMPHOMA
    Alexandra Levine; Fiscal Year: 1993
    ..a prospective correlative therapeutic trial (Appendix #1) which employs m-BACOD chemotherapy with dideoxycytidine (ddC) and Granulocyte-CSF (r-met Hu G-CSF) support: 1) Effective chemotherapy together with effective anti-retroviral ..
  42. AROMATIC L-AMINO ACID DECARBOXYLASE MODULATION
    NORTON NEFF; Fiscal Year: 1992
    ..These studies will change our concepts about neuronal AAAD and provide insight into the mechanism of action of psychoactive drugs...
  43. ROLE OF MULTIDRUG RESISTANCE MUTATION IN HIV FITNESS
    Prem Sharma; Fiscal Year: 2002
    ..Notably, L74V mutation in RT has been shown to be selected by several nucleoside RT inhibitors, including ddI, ddC, ABC and DXG...
  44. FLOW CYTROMETRIC ANALYSIS OF HIV-INFECTED PBMC
    JAMES MCSHARRY; Fiscal Year: 1990
    ..virus (HIV), will be used to monitor the effect of antiviral therapies such as Zidovudine (AZT), dideoxycytidine (ddC), and dideoxyinosine (ddi) on the number of HIV- infected cells in AIDS patients undergoing these treatments...
  45. Naturally Occurring HIV-1 Inhibitors
    Mario Canki; Fiscal Year: 2007
    ..by over 90%, which is comparable to treatment with the nucleoside analogue 2', 3'- didoxycytidine (ddC)...
  46. DATA COORDINATING CENTER: PEDIATRIC RENAL DISEASE STUDY
    Vernon Chinchilli; Fiscal Year: 1991
    The Data Coordinating Center (DDC) will continue to be responsible for all data management and biostatistical analysis in the recently funded extension for the "Growth Failure in Children with Renal Diseases" (GFRD) Clinical Trial...
  47. EXPERIMENTAL PATHOGENESIS & THERAPY OF OCULAR ADENOVIRUS
    Y Gordon; Fiscal Year: 2006
    ..In this competing renewal, we will evaluate several promising antivirals (ddC, NCT, CPE-C) in vitro and in our rabbit ocular model and determine the best candidate for clinical development...
  48. Gene therapy for Parkinson's Disease
    Mei Sun; Fiscal Year: 2006
    ..I have recently shown that co-expression of TH and aromatic amino acid decarboxylase (AADC) supports both biochemical and behavioral correction of the rat model of PD...
  49. GRAFTING GENETICALLY MODIFIED CELLS TO THE BRAIN
    Fred Gage; Fiscal Year: 2000
    ..In the future, combinations of both neurotransmitter replacement and neurotrophic factor delivery strategies will also be studied. ..
  50. NUCLEOTIDE METABOLISM IN LYMPHOCYTES AND MACROPHAGES
    Dennis Carson; Fiscal Year: 1991
    ..2) to compare the metabolian in lymphocytes and monocytes of dideoxynucloosides vith anti-HIV activity (AZT, ddC, ddA, 2-chloro-ddA, ddI, and others), and their effects on deoxynucleotide pool kinetics; and (3) to use novel cell ..
  51. Effect of AADC gene transfer on L-dopa induced dyskinesia in MPTP monkeys
    Robert Richardson; Fiscal Year: 2008
    ..in Parkinson's disease (PD) can be ameliorated by the reintroduction of aromatic L-amino acid decarboxylase (AADC) expression in the striatum, via gene transfer...
  52. Universal Technology for Profiling the Dynamics of Normal & Oncogenic Signaling
    Karen Anderson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  53. Novel Approach to Study Transient Enzyme Intermediates
    Karen Anderson; Fiscal Year: 2008
    ..These studies will aid in pioneering a powerful and novel analytical methodology for detecting, characterizing and quantitating enzyme intermediates on a rapid time scale. ..
  54. AROMATIC L-AMINO ACID DECARBOXYLASE MODULATION
    NORTON NEFF; Fiscal Year: 2003
    ..This proposal has direct clinical relevance for PD, as it addresses the functionality of an enzyme absolutely required for successful L-DOPA therapy. ..
  55. PF-L-DOPA: a MRI tool for developmental neurobiology
    Sherry Dingman; Fiscal Year: 2005
    ..This new MRI methods will reveal structural and functional brain alterations during development, making it possible to monitor the neurobiological impact of exposure to drugs. ..
  56. MECHANISTIC STUDIES ON PEP UTILIZING ENZYMES
    Karen Anderson; Fiscal Year: 2003
    ..In addition as the investigator develops the quantitative aspects of the rapid mixing, pulsed-flow ESI-MS technique further, she will extend the studies of these enzymes to determine the full kinetic profile. ..
  57. A Molecular Approach For Opportunistic HIV-1 Infections
    Karen Anderson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. CELLULAR REGULATION OF TYROSINE HYDROXYLASE
    John Haycock; Fiscal Year: 2001
    ..The effects of haloperidol on Ser19, Ser3l, and Ser4O phosphorylation will be studied by immunohistochemical and blot immunolabeling procedures using site- and phosphorylation state-specific antibodies. ..
  59. NEUROPEPTIDES AND SMALL CELL CARCINOMA
    WILLIAM NORTH; Fiscal Year: 2002
    ..The information obtained is expected to result in effective chemotherapeutic and immunotherapeutic interventions for all patients with limited and extensive SCCL. ..
  60. VANDERBILT ADULT AIDS CLINICAL TRIALS UNIT
    David Haas; Fiscal Year: 2006
    ..The proposed ACTU will not only enroll patients into ACTG clinical trials, but will provide the ACTG the ability to address important questions concerning AIDS treatment and pathogenesis. ..
  61. CNS Viral Dynamics and Cellular Immunity During AIDS
    David Haas; Fiscal Year: 2009
    ..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
  62. RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGING
    Stanislav Kasl; Fiscal Year: 2008
    ..In addition, Ph.D. candidates in biostatistics who will work with our biostatistics faculty on developing new techniques for the analysis of longitudinal data on older persons will also be eligible for support. ..
  63. Synthesis/Biological evaluation of Anti-HIV Nucleosides
    David Chu; Fiscal Year: 2005
    ..This is the first such studies demonstrating the potential of this molecular modeling approach. ..