DCC

Summary

Gene Symbol: DCC
Description: DCC netrin 1 receptor
Alias: CRC18, CRCR1, IGDCC1, MRMV1, NTN1R1, netrin receptor DCC, colorectal cancer suppressor, deleted in colorectal carcinoma, immunoglobulin superfamily DCC subclass member 1, tumor suppressor protein DCC
Species: human

Top Publications

  1. ncbi Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas
    J A Meyerhardt
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0638, USA
    Cell Growth Differ 10:35-42. 1999
  2. doi Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development
    P N Harter
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 36:623-35. 2010
  3. pmc Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
    G Hu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan
    Mol Cell Biol 19:724-32. 1999
  4. ncbi The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
    Masoud Shekarabi
    Centre for Neuronal Survival, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Mol Cell Neurosci 19:1-17. 2002
  5. ncbi The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism
    Xiaodong Li
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 277:37788-97. 2002
  6. ncbi DCC association with lipid rafts is required for netrin-1-mediated axon guidance
    Zoltan Herincs
    Death Receptor Signalling Laboratory Equipe ATIP CNRS, Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre A Lacassagne 33 Avenue Valombrose 06189 Nice, France
    J Cell Sci 118:1687-92. 2005
  7. ncbi Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth
    Yi Xie
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Nat Cell Biol 7:1124-32. 2005
  8. pmc DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1
    Alice Ly
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Cell 133:1241-54. 2008
  9. ncbi Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
    K Keino-Masu
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 87:175-85. 1996
  10. ncbi Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin
    Brian V Geisbrecht
    Howard Hughes Medical Institute and the Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:32561-8. 2003

Research Grants

  1. Greg J Bashaw; Fiscal Year: 2016
  2. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
  3. Presenilins and Cell Adhesion Molecules
    Angele Parent; Fiscal Year: 2012
  4. The Coordination of Netrin Signal Transduction
    Guofa Liu; Fiscal Year: 2011
  5. Molecular Mechanisms Underlying Axon Pathfinding
    Wen Cheng Xiong; Fiscal Year: 2012
  6. AXON GUIDANCE IN THE SPINAL CORD
    Zaven Kaprielian; Fiscal Year: 2010
  7. Cynthia D Morris; Fiscal Year: 2016
  8. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
  9. HUA LINDA CAI; Fiscal Year: 2016
  10. George J Schwartz; Fiscal Year: 2016

Detail Information

Publications337 found, 100 shown here

  1. ncbi Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas
    J A Meyerhardt
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0638, USA
    Cell Growth Differ 10:35-42. 1999
    ..The deleted in colorectal cancer (DCC) protein has been implicated as a netrin-1 receptor component...
  2. doi Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development
    P N Harter
    Institute of Brain Research, University of Tuebingen, Tuebingen, Germany
    Neuropathol Appl Neurobiol 36:623-35. 2010
    Deleted in colorectal cancer (DCC) and its ligand netrin-1 are known as axonal guidance factors, being involved in angiogenesis, migration and survival of precursor cells in the embryonic mammalian central nervous system (CNS)...
  3. pmc Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
    G Hu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan
    Mol Cell Biol 19:724-32. 1999
    ..Independent studies have shown that Sina and its highly related mammalian homologues Siah-1 and Siah-2 bind to the DCC (deleted in colorectal cancer) protein and promote its proteolysis via the ubiquitin-proteasome pathway...
  4. ncbi The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
    Masoud Shekarabi
    Centre for Neuronal Survival, McGill University, Montreal, Quebec, H3A 2B4, Canada
    Mol Cell Neurosci 19:1-17. 2002
    ..We show that the netrin-1 receptor, deleted in colorectal cancer (DCC), is present at filopodia tips in growth cones of embryonic rat spinal commissural neurons...
  5. ncbi The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism
    Xiaodong Li
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada
    J Biol Chem 277:37788-97. 2002
    ..b>DCC (deleted in colorectal cancer) is a receptor for netrin-1 implicated in mediating these responses...
  6. ncbi DCC association with lipid rafts is required for netrin-1-mediated axon guidance
    Zoltan Herincs
    Death Receptor Signalling Laboratory Equipe ATIP CNRS, Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre A Lacassagne 33 Avenue Valombrose 06189 Nice, France
    J Cell Sci 118:1687-92. 2005
    ..a diffusible laminin-related molecule that both attracts and repels growth cones via interaction with its receptor DCC (deleted in colorectal cancer)...
  7. ncbi Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth
    Yi Xie
    Institute of Molecular Medicine and Genomics and Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Nat Cell Biol 7:1124-32. 2005
    ..PlTPalpha interacts with the netrin receptor DCC (deleted in colorectal cancer) and neogenin...
  8. pmc DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1
    Alice Ly
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA
    Cell 133:1241-54. 2008
    ..They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin receptor DCC. However, previous studies suggest that additional receptor components are required...
  9. ncbi Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
    K Keino-Masu
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 87:175-85. 1996
    ..We show that Deleted in Colorectal Cancer (DCC), a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses ..
  10. ncbi Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin
    Brian V Geisbrecht
    Howard Hughes Medical Institute and the Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:32561-8. 2003
    ..Netrins interact with members of two distinct families of transmembrane receptors, represented by DCC (deleted in colorectal cancer) and UNC5...
  11. pmc Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system
    Latif A Wafa
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 2B5, Canada
    Biochem J 375:373-83. 2003
    ..Together, our data demonstrate that DDC interacts with AR to enhance steroid receptor transactivation, which may have important implications in prostate cancer progression...
  12. ncbi Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation
    Robert P Kruger
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 24:10826-34. 2004
    Netrin and its receptors Unc5 and deleted in colorectal carcinoma (DCC) regulate axon guidance and cell migration. We defined domains involved in the interactions between netrin-1, DCC, and Unc5c...
  13. ncbi The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
    P Mehlen
    Program on Aging, The Burnham Institute, La Jolla, California 92037, USA
    Nature 395:801-4. 1998
    The development of colonic carcinoma is associated with the mutation of a specific set of genes. One of these, DCC (deleted in colorectal cancer), is a candidate tumour-suppressor gene, and encodes a receptor for netrin-1, a molecule ..
  14. ncbi Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor
    V Corset
    Laboratoire Apoptose et Différenciation, label La Ligue Centre de Génétique Moléculaire et Cellulaire, CNRS UMR 5534, Universite Lyon 1, Villeurbanne, France
    Nature 407:747-50. 2000
    ..The DCC (for deleted in colorectal cancer) protein was proposed as a receptor for netrin-1 in the light of many ..
  15. ncbi Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
    Christelle Forcet
    Apoptosis Differentiation Laboratory label La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Nature 417:443-7. 2002
    ..Deleted in colorectal cancer (Dcc) is a receptor for netrin-1 that mediates its chemoattractive effect on commissural axons, but the signalling ..
  16. ncbi Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis
    H D Kato
    Department of Molecular Genetics, Division of Molecular and Cell Therapeutics, Medical Institute of Bioregulation, Kyushu University, Beppu City, Oita 874 0838, Japan
    Gynecol Oncol 95:281-9. 2004
    Although DCC has been considered as a candidate tumor suppressor, the roles it plays in the uterine endometrium and in the carcinogenic process remains unclear...
  17. ncbi Focal adhesion kinase in netrin-1 signaling
    Xiu Rong Ren
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    Nat Neurosci 7:1204-12. 2004
    ..Here we report that the netrin receptor DCC (deleted in colorectal cancer) interacts with the focal adhesion kinase (FAK), a kinase implicated in ..
  18. doi Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor
    Jean Pierre Roperch
    Institut National de la Sante, Recherche Medicale U673 Molecular and Clinical Oncology of Solid Tumors, Universite Pierre et Marie Curie Paris 6, Hopital Saint Antoine, Paris, France
    Cancer Res 68:8231-9. 2008
    Netrins and their receptors deleted in colon cancer (DCC), neogenin, UNC5, and integrins are involved in axon guidance, epithelial morphogenesis, vascular pattering, cancer cell survival, invasion, tumor angiogenesis, and metastasis...
  19. ncbi [Abnormalities of the p53, N-ras, DCC and FLT-3 genes in myelodysplastic syndromes]
    K Nakamura
    Department of 3rd Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:143-8. 2001
    ..mutations of N-ras, p53 and FMS-like tyrosine kinase 3 (FLT-3) genes and loss of expression of the deleted in colorectal carcinoma (DCC) gene were analyzed in 59 patients with myelodysplastic syndromes (MDS)...
  20. ncbi Estrogen and progesterone receptor determinations in breast cancer. Technology, biology and clinical significance
    S M Thorpe
    Fibiger Institute, Laboratory of Tumor Endocrinology, Rigshospitalet, Copenhagen, Denmark
    Acta Oncol 27:1-19. 1988
    ..Since the traditionally used ligand binding assay (dextran-coated charcoal (DCC) method) is highly sensitive even to slight modifications in assay procedure, intra- and interlaboratory ..
  21. pmc Telomere erosion is independent of microsatellite instability but related to loss of heterozygosity in gastric cancer
    D C Fang
    Southwest Hospital Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 7:522-6. 2001
    To correlate the length of the telomere to microsatellite instability (MSI) and loss of heterozygosity (LOH) of APC, MCC and DCC genes in gastric carcinomas.
  22. ncbi Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine
    L A Baltina
    Institute of Organic Chemistry Ufa Research Centre of RAS, 71 Prospect Oktyabrya, Ufa, 450054, Russian Federation
    Curr Med Chem 10:155-71. 2003
    ..Bioactive amides of GL were synthesized using chloroanhydride technique and N,N'-diciclohexylcarbodiimide (DCC) method...
  23. ncbi Estrogen receptor in primary breast cancer estimated in paraffin-embedded tissue. A study of its usefulness compared to dextran-coated charcoal assay
    J Andersen
    Department of Oncology and Radiotherapy, Danish Cancer Society, Arhus
    Acta Oncol 30:685-90. 1991
    ..001) and survival (p less than 0.001) than ER negative patients. The DCC assay showed an advantage of ER positive patients of the same magnitude...
  24. pmc The prognostic significance of allelic imbalance at key chromosomal loci in oral cancer
    M Partridge
    Kings College School of Medicine and Dentistry, Denmark Hill, London, UK
    Br J Cancer 79:1821-7. 1999
    ..were screened for allelic imbalance (AI) at 3p24-26, 3p21, 3p13, 8p21-23, 9p21, 9q22 and within the Rb, p53 and DCC tumour suppressor genes...
  25. ncbi Characterization of laboratory working standard for quality control of immunometric and radiometric estrogen receptor assays. Clinical evaluation on breast cancer biopsies. Italian Committee for Hormone Receptor Assays Standardization
    A Piffanelli
    Institute of Radiology, University of Ferrara, Italy
    Tumori 75:550-6. 1989
    ..working standard material for quality control of estrogen receptor (ER) determination with dextran-coated charcoal (DCC) and enzyme immunoassay (EIA) methods...
  26. ncbi Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers
    Mustafa Akkiprik
    Marmara University, School of Medicine, Department of Medical Biology, Tibbyie C no 49, 34668 Haydarpasa, Istanbul, Turkey
    J Gastrointestin Liver Dis 16:11-7. 2007
    Genetic alterations of p53, K-ras and DCC genes have a pivotal role in the colorectal cancer progression...
  27. ncbi [A study on the loss of heterozygosity at the APC/MCC and DCC genetic loci in colorectal cancers]
    Y Lui
    Department of Gastroenterology, Southwest Hospital, Third Military Medical College, Chongqing
    Zhonghua Nei Ke Za Zhi 35:439-43. 1996
    To evaluate the role of APC, MCC and DCC genes in the development and progression of colorectal cancers, loss of heterozygosity (LOH) at these genetic loci was investigated in 41 surgically resected specimens of colorectal cancer by ..
  28. pmc Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival
    N P Zauber
    Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
    J Clin Pathol 57:938-42. 2004
    ..The secondary aim was to correlate the data on these molecular genetic changes and micrometastases with survival...
  29. ncbi Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse
    C Luongo
    McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison 53706, USA
    Genes Chromosomes Cancer 17:194-8. 1996
    ..This chromosome carries both the Mcc and Dcc genes, which are homologs of genes that have been implicated in human colorectal cancer...
  30. ncbi Reduced expression of APC and DCC gene protein in breast cancer
    K Y Ho
    Department of Clinical Pathology, Tuen Mun Hospital, New Territories, Hong Kong
    Histopathology 35:249-56. 1999
    To investigate if the adenomatous polyposis coli (APC) protein and the deleted in colorectal cancer (DCC) protein expression can be demonstrated by an immuno-histochemical method and to study the role of APC and DCC gene inactivation in ..
  31. pmc Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability
    D C Fang
    Department of Gastroenterology, 3rd Military Medical University, Southwest Hospital, Chongqing, China
    J Clin Pathol 52:504-8. 1999
    ..METHODS: Six microsatellite loci and loss of heterozygosity at APC, DCC, and MCC were analysed by polymerase chain reaction based methods in 53 cases of advanced gastric cancer...
  32. ncbi [The possible role of loss of heterozygosity at APC, MCC and DCC genetic loci in esophageal carcinoma]
    M Wang
    Southwest Hospital, Third Military Medical University, Chongqing 400038
    Zhonghua Zhong Liu Za Zhi 21:16-8. 1999
    OBJECTIVE: To investigate the alterations of APC, MCC and DCC genes in human esophageal carcinoma...
  33. ncbi Optical resolution of asymmetric triacylglycerols by chiral-phase high-performance liquid chromatography
    Y Iwasaki
    Laboratory of Molecular Biotechnology, Graduate School of Bio- and Agro-Sciences, Nagoya University, Japan
    J Chromatogr A 905:111-8. 2001
    ..The separation of another pair of asymmetric TGs, 1-docosahexaenoyl-2,3-dicapryroyl-sn-glycerol (DCC) and 1,2-dicapryroyl-3-docosahexaenoyl-sn-glycerol (CCD), was achieved with the CHIRALCEL OD column...
  34. ncbi Existence of multiple outbreaks of viral gastroenteritis among infants in a day care center in Japan
    S Akihara
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Arch Virol 150:2061-75. 2005
    A total of 921 fecal specimens collected from 44 infants in a day care center (DCC) in Tokyo, Japan during June 1999 to July 2000 were tested for the presence of rotavirus, norovirus, sapovirus, astrovirus and adenovirus by reverse-..
  35. ncbi Evaluation of the overall accuracy of the DeLaval cell counter for somatic cell counts in ovine milk
    C Gonzalo
    Departamento de Produccion Animal, Facultad de Veterinaria, Universidad de Leon, 24071 Leon, Spain
    J Dairy Sci 89:4613-9. 2006
    The DeLaval cell counter (DCC) is a portable device designed for on-farm somatic cell count (SCC) analysis in bovine milk. This study evaluated the performance of the DCC when analyzing ovine milk...
  36. ncbi Description and phylogeny of a new species of Eimeria from double-crested cormorants (Phalacrocorax auritus) near Fort Gaines, Georgia
    Michael J Yabsley
    Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    J Parasitol 92:385-8. 2006
    The renal parasite Eimeria auritusi has caused several mortality events in double-crested cormorants (DCC; Phalacrocorax auritus) in the Midwest and southeastern United States...
  37. ncbi Deleted in colorectal cancer protein expression as a possible predictor of response to adjuvant chemotherapy in colorectal cancer patients
    Rivka Gal
    Department of Pathology, Hasharon Hospital, Petah Tikva, Israel
    Dis Colon Rectum 47:1216-24. 2004
    The deleted in colorectal cancer (DCC) gene predicts a poor outcome for patients with colorectal carcinoma...
  38. ncbi Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers
    Y Huang
    Department of Microbiology and Immunology, University of Maryland, Baltimore 21201
    Cancer Res 52:6525-30. 1992
    ..46 squamous cell carcinomas and 26 adenocarcinomas) for loss of heterozygosity at the p53, Rb, APC, MCC, and DCC loci...
  39. ncbi Ion-exchange chromatography by dicarboxyl cellulose gel
    U J Kim
    Department of Biomaterials Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Chromatogr A 919:29-37. 2001
    ..periodate oxidation followed by chlorite oxidation to form spatially paired carboxyl groups (dicarboxyl cellulose, DCC)...
  40. ncbi Immunohistochemical steroid receptor detection in frozen breast cancer tissue. A multicenter investigation
    B B Rasmussen
    Department of Pathology, Finsen Institute, Rigshospitalet, Copenhagen, Denmark
    Acta Oncol 27:757-60. 1988
    ..As reference is used a conventional biochemical assay, dextran-coated-charcoal assay (DCC)...
  41. ncbi Delayed umbilical cord clamping for reducing anaemia in low birthweight infants: implications for developing countries
    Patrick F van Rheenen
    Paediatrics Gastroenterology, Department of Paediatrics, University Medical Centre, Groningen, The Netherlands
    Ann Trop Paediatr 26:157-67. 2006
    ..Delayed cord clamping (DCC) has been shown to be a simple, safe and cost-free delivery procedure that augments red cell mass in appropriate-..
  42. ncbi [A research of migrating motor complex in patients with irritable bowel syndrome]
    Shen Hao Wang
    Department of Gastroenterology, the Second Affiliated Hospital of Medical College, Xi an Jiaotong University, Xi an 710004, China
    Zhonghua Nei Ke Za Zhi 48:106-10. 2009
    ..To explore whether discrete clustered contractions (DCC) are connected with abdominal pain in IBS patients. To improve the method of measuring gastroenteric motility (esp...
  43. pmc Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons
    Elyanne M Ratcliffe
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    Dev Neurobiol 68:960-71. 2008
    Vagal sensory axons navigate to specific sites in the bowel during fetal life. Netrin/deleted in colorectal cancer (DCC) were found to mediate the attraction of vagal sensory axons to the fetal mouse gut...
  44. ncbi Determination of estrogen receptors in paraffin-embedded tissue. Techniques and the value in breast cancer treatment
    J Andersen
    Danish Cancer Society, Department of Experimental Clinical Oncology, Aarhus
    Acta Oncol 31:611-27. 1992
    ..has traditionally been measured using labelled hormone in binding assays--often in dextran-coated charcoal assays (DCC)...
  45. ncbi Pharyngeal colonization with Haemophilus influenzae type b among healthy Turkish infants and children
    Mustafa Bakir
    Department of Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Turkey
    Pediatr Int 44:381-6. 2002
    ....
  46. ncbi Induction of micronucleated erythrocytes in rodents by diisopropylcarbodiimide and dicyclohexylcarbodiimide: dependence on exposure protocol
    K L Witt
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 33:65-74. 1999
    The induction of micronucleated erythrocytes by diisopropylcarbodiimide (DIC) and dicyclohexylcarbodiimide (DCC) was investigated as part of a U.S...
  47. ncbi Carriage of penicillin-resistant Streptococcus pneumoniae by children in day-care centers during an intervention program in Malmo, Sweden
    P Nilsson
    Department of Pediatrics, University of Lund, University Hospital, Malmo, Sweden
    Pediatr Infect Dis J 20:1144-9. 2001
    ..An increasing incidence of penicillin-resistant Streptococcus pneumoniae (PRP) was detected in Malmo in 1994...
  48. ncbi P53 and Rb tumor suppressor gene alterations in gastric cancer
    Rejane Mattar
    Department of Gastroenterology, Hospital das Clinicas, Faculty of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil
    Rev Hosp Clin Fac Med Sao Paulo 59:172-80. 2004
    Inactivation of tumor suppressor genes has been frequently observed in gastric carcinogenesis. Our purpose was to study the involvement of p53, APC, DCC, and Rb genes in gastric carcinoma.
  49. ncbi Surveillance to estimate the burden of rotavirus gastroenteritis in children aged less than 3 years attending day care centers in Paris, France
    Emmanuel Grimprel
    Hopital d Enfants Armand Trousseau, AP HP, Paris, France
    Hum Vaccin 6:399-406. 2010
    ..3 loose stools/24 hours with or without vomiting) for <14 days] and outbreaks of acute GE (≥3 cases in a DCC with onset within 11 days)...
  50. ncbi Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration
    L Astic
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Université VClaude Bernard Lyon 1, France
    Neuroscience 109:643-56. 2002
    ..The transmembrane DCC (deleted in colorectal cancer) receptor is described as netrin-1 receptor and is involved in the attractive effects ..
  51. doi Comparative varicella vaccine effectiveness during outbreaks in day-care centres
    M Spackova
    European Programme for Intervention Epidemiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden
    Vaccine 28:686-91. 2010
    Routine varicella vaccination for children >11 months was introduced in Germany in 2004 with three different vaccine brands available. In 2008 and 2009, we investigated seven varicella outbreaks in day-care centres (DCC).
  52. ncbi [Study on loss of heterozygosity and microsatellite instability in hepatocellular carcinoma]
    Wen ming Cong
    Department of Pathology, Oriental Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai 200438, China
    Zhonghua Bing Li Xue Za Zhi 34:71-4. 2005
    ..To investigate the role of loss of heterozygosity (LOH) in tumor suppressor genes (TSG) and microsatellite instability (MSI) in hepatocarcinogenesis, as well as their correlation with clinicopathologic features...
  53. ncbi Clinical usefulness of estrogen receptor immunocytochemistry in human breast cancer
    P Querzoli
    Istituto di Anatomia, Istologia e Citologia Patologica, , Italy
    Tumori 78:287-90. 1992
    ..ER assay by the dextran-coated charcoal method (DCC) was also performed in 189 tumors...
  54. ncbi Solid-phase synthesis of a farnesylated CaaX peptide library: inhibitors of the Ras CaaX endoprotease
    E K Dolence
    Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112 0850, USA
    J Comb Chem 2:522-36. 2000
    ..N-Acetyl-S-(E, E-farnesyl)-L-cysteine was coupled to resin-bound a(1)a(2) dipeptide using HOBt/DCC activation in conjunction with N-BOC chemistry...
  55. ncbi Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)
    N Fortunati
    Laboratorio di Endocrinologia, II UO ADU Medicina Generale, Azienda Ospedaliera S Giovanni B ta and Dip Fisiopatologia Clinica, Universita di Torino, Italy
    J Steroid Biochem Mol Biol 70:73-80. 1999
    ..MCF-7 cells were maintained in DCC-FCS (treated with DCC to remove steroids), in SHBG-FREE/DCC-FCS (treated with DCC and with a specific affinity ..
  56. ncbi Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus
    David M Howell
    Sensory Neuroscience Research Center, West Virginia University, Morgantown, West Virginia 26506, USA
    J Comp Neurol 504:533-49. 2007
    ..Therefore, we reasoned that netrin-DCC and slit-robo signaling systems function in the guidance of VCN axons...
  57. ncbi Chromosomal localization of the loci responsible for dystrophic cardiac calcinosis in DBA/2 mice
    S R Brunnert
    College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genomics 59:105-7. 1999
    Dystrophic cardiac calcinosis (DCC) occurs in certain inbred strains of mice, including DBA/2 and C3H/He, and is generally found as an incidental lesion in adult animals at necropsy...
  58. ncbi Asymptomatic salmonellosis among children in day-care centers in Mérida, Yucatan, Mexico
    R A Oberhelman
    Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    Pediatr Infect Dis J 20:792-7. 2001
    Child day-care centers (DCC) have become common in many lower and middle income countries, presenting new problems that may differ from those of DCC in more developed countries...
  59. ncbi Vascular endothelial growth factor in dialysate in relation to intensity of peritoneal inflammation
    K Pawlaczyk
    Department of Pathophysiology and Nephrology, Poznan Medical School, Poznan Poland
    Int J Artif Organs 31:535-44. 2008
    ....
  60. ncbi [Semi-synthesis of derivatives with C-3' and C-4' trans-configuration from (+)-praeruptorin A]
    Ling Yi Kong
    Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
    Yao Xue Xue Bao 38:358-63. 2003
    ....
  61. ncbi Androgen-independent growth is induced by neuropeptides in human prostate cancer cell lines
    J Jongsma
    Department of Experimental Urology, Erasmus University, Rotterdam, The Netherlands
    Prostate 42:34-44. 2000
    ..This may be caused by altered specificity of the androgen receptor (AR), by ligand-independent stimulation of the AR, or by paracrine growth modulation by neuropeptides secreted by neuroendocrine (NE) cells...
  62. ncbi Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment
    Tobias Straub
    Department of Molecular Biology, Adolf Butenandt Institute, Schillerstr 44, 80336, Munich, Germany
    Chromosoma 114:352-64. 2005
    Dosage compensation in Drosophila is controlled by a complex (DCC) of proteins and noncoding RNA that binds specifically to the male X chromosome and leads to fine-tuning of transcription...
  63. ncbi Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice
    B B Hayes
    Department of Pharmacology and Toxicology, Medical College of Virginia, Commonwealth University, Richmond 23298, USA
    Drug Chem Toxicol 21:195-206. 1998
    Dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are two commonly used coupling reagents in protein synthesis resulting in exposure of individuals in chemical and pharmaceutical industries as well as research laboratories ..
  64. doi Expression of DCC in differentiating ameloblasts from developing tooth germs in rats
    H J Kim
    Department of Oral Anatomy, School of Dentistry, Institute of Biotechnology, Wonkwang University, Iksan 570 749, South Korea
    Arch Oral Biol 54:563-9. 2009
    This study examined the expression pattern of the Deleted-in-colorectal-carcinoma (DCC) gene in developing rat tooth germs.
  65. pmc HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 5:e10338. 2010
    ..The purpose of this study was to identify the targets of DNMT3B, an essential DNA methyltransferase in mammals, in colon cancer...
  66. pmc A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice
    Zouhair Aherrahrou
    Department of Medicine II, University of Luebeck, Luebeck, Germany
    Am J Pathol 164:1379-87. 2004
    ..A similar response of myocardium to injury, referred to as dystrophic cardiac calcinosis (DCC), occurs in certain inbred strains of mice...
  67. ncbi Participation of hyf-encoded hydrogenase 4 in molecular hydrogen release coupled with proton-potassium exchange in Escherichia coli
    K Bagramyan
    Department of Biophysics, Biological Faculty, Yerevan State University, Republic of Armenia
    Membr Cell Biol 14:749-63. 2001
    ..5. The ion fluxes had stable stoichiometry 2H+/K+ and were N,N'-dicyclohexylcarbodiimide (DCC)-inhibitable at different external pH and K+ activity...
  68. ncbi Radioligand-labeled binding assay and immunochemical assay for estrogen receptor in 115 human breast cancers
    A Riccobon
    Divisione di Oncologia, Ospedali G.B. Morgagni-L. Pierantoni,
    Tumori 74:167-70. 1988
    ..for the determination of estrogen receptor levels in tumor cytosols in comparison with the currently used DCC method...
  69. ncbi Use of the DeLaval cell counter (DCC) on goats' milk
    Elizabeth Berry
    Institute for Animal Health, Compton, Newbury RG20 7NN
    J Dairy Res 74:345-8. 2007
    ..The use of the DeLaval cell counter (DCC) on goats' milk was compared with this reference method...
  70. pmc The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription
    I V Kotlikova
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
    Genetics 172:963-74. 2006
    In Drosophila, the dosage compensation complex (DCC) mediates upregulation of transcription from the single male X chromosome...
  71. ncbi Cytomegalovirus excretion in children attending day-care centers
    Daniel E Noyola
    Departamento de Microbiologia, Universidad Autonoma de San Luis Potosi, Mexico
    Arch Med Res 36:590-3. 2005
    Healthy children attending day-care centers (DCC) may excrete cytomegalovirus (CMV) frequently. Mothers of children excreting CMV are at higher risk for acquiring this infection than mothers of children not excreting CMV...
  72. ncbi Amiodarone after unsuccessful direct-current cardioversion of persistent atrial fibrillation
    Dariusz A Kosior
    I Katedra i Klinika Kardiologii, Akademia Medyczna, ul Banacha 1 a, 02 097 Warszawa
    Kardiol Pol 63:585-92; discussion 593-4. 2005
    ..To assess the safety and efficacy of amiodarone used after unsuccessful direct current (DC) cardioversion of persistent atrial fibrillation (AF)...
  73. ncbi Outcomes of delayed chest closure after bilateral lung transplantation
    Seth D Force
    Division of Cardiothoracic Surgery, Emory University Hospital and Clinic, Atlanta, Georgia, USA
    Ann Thorac Surg 81:2020-4; discussion 2024-5. 2006
    Delayed chest closure (DCC) may be used after bilateral lung transplantation when significant bleeding/coagulopathy or severe pulmonary edema exists...
  74. doi An alternative splice variant in Abcc6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice
    Zouhair Aherrahrou
    Department of Medicine II, Univerrsity of Luebeck, 23538 Luebeck, Germany
    J Biol Chem 283:7608-15. 2008
    Dystrophic cardiac calcification (DCC) is an autosomal recessive trait characterized by calcium phosphate deposits in myocardial tissue...
  75. pmc A condensin-like dosage compensation complex acts at a distance to control expression throughout the genome
    Judith Jans
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 97420, USA
    Genes Dev 23:602-18. 2009
    In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X)...
  76. ncbi Differential inhibition of single and cluster type tumor cell migration
    Revekka Harisi
    First Institute of Pathology and Experimental Cancer Research, Faculty of Medicine, Semmelweis University, Budapest, Hungary
    Anticancer Res 29:2981-5. 2009
    ..cells was compared in a Boyden chamber and in an extracellular matrix (ECM)-based three-dimensional cell culture (3-DCC) model system...
  77. pmc The C. elegans dosage compensation complex propagates dynamically and independently of X chromosome sequence
    Sevinc Ercan
    Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Curr Biol 19:1777-87. 2009
    The C. elegans dosage compensation complex (DCC) associates with both X chromosomes of XX animals to reduce X-linked transcript levels...
  78. ncbi Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules
    J Holm
    Department of Neurobiology, Swiss Federal Institute of Technology, Honggerberg, Zurich, Switzerland
    Eur J Neurosci 8:1613-29. 1996
    ..The similarity with other members of the Ig superfamily [e.g. neural cell adhesion molecule (N-CAM), DCC, HLAR, rse] is 16-11%...
  79. ncbi Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomas
    H van Dekken
    Department of Pathology, University Hospital Rotterdam, Erasmus University, The Netherlands
    Cancer Res 59:748-52. 1999
    ..1 (TSHR), 16q23, 18q21 (DCC, P15) and 21q21. Minimal overlapping amplified sites could be seen at 5p14 (MLVI2), 6p12-21...
  80. ncbi Expression of oncogenes, tumour suppressor, mismatch repair and apoptosis-related genes in primary and metastatic melanoma cells
    H Zhang
    Department of Dermatology, Clinical Research Centre, Linkoping University, S 581 85 Linkoping, Sweden
    Int J Oncol 19:1149-53. 2001
    ..We simultaneously examined the expression of p73, c-erbB-2, ras, p53, Mdm2, p27, DCC, hMLH-1, hMSH-2, bcl-2, Bax and NF-kappaB, by immunocytochemistry, in both primary and metastatic melanoma cell ..
  81. ncbi Expression of UNC-5 in the developing Xenopus visual system
    Richard B Anderson
    Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY Cambridge, UK
    Mech Dev 118:157-60. 2002
    Netrin-1 and its receptors deleted in colorectal cancer (DCC) and neogenin are expressed within the developing visual system and have been implicated in mediating axon guidance and cell migration...
  82. ncbi A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis
    Sanjay Popat
    Department of Medicine, Royal Marsden Hospital, London SW3 6JJ, United Kingdom
    Eur J Cancer 41:2060-70. 2005
    ..investigating the relationship between colorectal cancer survival and chromosome 18q allelic imbalance (AI)/loss of DCC expression (LOE) have been inconsistent...
  83. ncbi Binding of netrin-4 to laminin short arms regulates basement membrane assembly
    Fiona I Schneiders
    Center for Biochemistry, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 282:23750-8. 2007
    Netrins were first identified as neural guidance molecules, acting through receptors that are members of the DCC and UNC-5 family...
  84. pmc Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC)
    Kimberly M Roth
    Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA
    FEMS Immunol Med Microbiol 53:72-8. 2008
    ..novicida infection not only causes pneumonia and liver damage, but also induces dystrophic cardiac calcinosis (DCC) in BALB/c mice. C57BL/6 mice also develop pneumonia and hepatic damage, but fail to develop DCC...
  85. doi Netrin-1 attenuates ischemic stroke-induced apoptosis
    T W Wu
    Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Section 2, Nangang, Taipei, Taiwan 115
    Neuroscience 156:475-82. 2008
    ..We also tested the ability of netrin-1 to attract intrinsic neuronal stem cells to the infarct area. Both DCC and UNC5H2 were expressed in neurosphere culture and netrin-1 attracted stem cells in an in vitro transwell assay...
  86. doi Dual sex-specific functions of Drosophila Upstream of N-ras in the control of X chromosome dosage compensation
    Solenn Patalano
    Centre de Regulacio Genomica, 08003 Barcelona, Spain
    Development 136:689-98. 2009
    ..compensation in Drosophila melanogaster involves the assembly of the MSL-2-containing dosage compensation complex (DCC) on the single X chromosome of male flies. Translational repression of msl-2 mRNA blocks this process in females...
  87. doi Dynamic covalent chemistry of the Nicholas ether-exchange reaction
    Nobuhiro Kihara
    Department of Chemistry, Faculty of Science, Kanagawa University, Tsuchiya, Hiratsuka 259 1293, Japan
    Org Lett 11:1313-6. 2009
    ..reaction was found to be reversible and can be used to synthesize complex molecules in dynamic covalent chemistry (DCC)...
  88. doi The influence of patient size on dose conversion coefficients: a hybrid phantom study for adult cardiac catheterization
    Perry Johnson
    Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, FL 32611, USA
    Phys Med Biol 54:3613-29. 2009
    ..It was also shown that if patient size is neglected when choosing a DCC, the organ and effective dose will be underestimated to an underweight patient and will be overestimated to an ..
  89. doi Intramedullary solitary fibrous tumor of dorsal spinal cord
    Pasqualino Ciappetta
    Department of Neurological and Psychiatric Sciences, University of Bari Medical School, Bari, Italy
    Neuropathology 30:273-8. 2010
    ..CGH], methylation status of O6-methylguanine-DNA methyltransferase [MGMT], p16, deleted in colorectal cancer [DCC] and death-associated protein kinase 1 [DAPK1])...
  90. pmc The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
    Torsten Fauth
    Adolf Butenandt Institute and Centre for Integrated Protein Science, Ludwig Maximilians University, 80336 Munich, Germany
    Nucleic Acids Res 38:3209-21. 2010
    ..melanogaster involves the selective targeting of the male X chromosome by the dosage compensation complex (DCC) and the coordinate, approximately 2-fold activation of most genes...
  91. doi The effects of storage temperature on goat milk somatic cell count using the DeLaval counter
    Davinia Sanchez-Macias
    Department of Animal Science, Las Palmas de Gran Canaria University, Arucas, 35413, Spain
    Trop Anim Health Prod 42:1317-20. 2010
    ..temperature and storage time on goat milk somatic cell counts (SCCs) determined using the DeLaval cell counter (DCC). SCCs were measured in 40 Majorera goat milk samples using the DCC device...
  92. doi CO2-efflux measurements for evaluating source zone natural attenuation rates in a petroleum hydrocarbon contaminated aquifer
    Natasha J Sihota
    University of British Columbia, Department of Earth and Ocean Sciences, Vancouver, BC, Canada
    Environ Sci Technol 45:482-8. 2011
    ..Here, the CO(2)-efflux at the ground surface is measured using a dynamic closed chamber (DCC) method to evaluate whether this technique can be used to assess the areal extent of the contaminant source zone ..
  93. doi Enhancing sensitivity of liquid chromatographic/ion-trap mass spectrometric determination of jasmonic acid by derivatization with N,N'-dicyclohexylcarbodiimide
    Jing Chen
    School of Pharmaceutical Sciences, Wuhan University, Wuhan, China
    Analyst 137:5436-40. 2012
    ..was often considered as a side reaction in the formation of amides and esters using N,N'-dicyclohexylcarbodiimide (DCC) as a condensation reagent. While in this study, DCC was used as a derivatization reagent directly...
  94. doi Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion
    Thomas Fothergill
    The University of Queensland, Queensland Brain Institute, Brisbane, QLD, Australia
    Cereb Cortex 24:1138-51. 2014
    ..These results provide the first evidence for how callosal axons integrate multiple guidance cues to navigate the midline. ..
  95. pmc Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells determine their commitment to apoptosis
    Thomas O'Hare
    Division of Hematology and Hematologic Malignancies, University of Utah, Huntsman Cancer Institute, Salt Lake City, Utah, USA
    Cancer Res 73:3356-70. 2013
    ..CML cell death for a panel of clinically important ABL TKIs (imatinib, nilotinib, dasatinib, ponatinib, and DCC-2036), we interrogated response of CML cell lines and primary CML cells following acute drug exposure using ..
  96. doi Chitosan/alginate crosslinked hydrogels: preparation, characterization and application for cell growth purposes
    Kemal Baysal
    TUBITAK, Marmara Research Center, Genetic Engineering and Biotechnology Institute, P O Box 21, 41470 Gebze Kocaeli, Turkey
    Int J Biol Macromol 59:342-8. 2013
    ..Compared to chitosan/alginate (1/2) hydrogel prepared with 1wt% DCC, the swelling of chitosan/alginate (1/2) hydrogels prepared with 3wt% DCC was limited...
  97. pmc Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion
    Ilya A Rybak
    I A Rybak Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Physiol 591:5491-508. 2013
    ..of these axons to the other side of the cord is controlled by axon guidance molecules, such as Netrin-1 and DCC. The cord also contains glutamatergic interneurons, whose axon guidance involves the EphA4 receptor...
  98. pmc Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity
    David Aguado-Llera
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Elche Alicante, Spain
    PLoS ONE 8:e78101. 2013
    ..MSL1 is a histone acetyl transferase-associated protein, known to intervene in the dosage compensation complex (DCC)...
  99. doi Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures
    Andreas Herrmann
    Firmenich SA, Division Recherche et Developpement, Route des Jeunes 1, B P 239, CH 1211 Geneve 8, Switzerland
    Chem Soc Rev 43:1899-933. 2014
    ..Dynamic combinatorial/covalent chemistry (DCC) has been used to read structural information by selectively assembling receptors with the optimum molecular fit ..
  100. ncbi [Disseminated cysticercosis: report of a case in Peru]
    Julio Maquera-Afaray
    Unidad de Infectología, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru
    Rev Peru Med Exp Salud Publica 31:370-4. 2014
    ..However, only a few reports of disseminated cysticercosis (DCC) exist in the world...
  101. pmc The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP
    Adam D Norris
    Programs in Genetics and Molecular, Cellular, and Developmental Biology, Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA
    Development 141:4395-405. 2014
    ..We previously discovered that attractive UNC-40/DCC receptor signaling stimulates growth cone filopodial protrusion and that repulsive UNC-40-UNC-5 heterodimers ..

Research Grants67

  1. Greg J Bashaw; Fiscal Year: 2016
    ..Slit and Netrin, and their Robo and Fra/DCC receptors, are highly conserved signaling molecules that regulate multiple aspects of circuit development...
  2. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..The proposed analyzer is based on new, powerful, proprietary, monochromatic doubly curved crystal (DCC) X-ray optics technology that greatly increases the efficiency and sensitivity for elemental analysis...
  3. Presenilins and Cell Adhesion Molecules
    Angele Parent; Fiscal Year: 2012
    ..APP, Notch ligands/Notch receptor, and several cell adhesion molecules (CAMs) including cadherins, protocadherins, DCC, ErbB4, ephrin/Eph receptors, nectin-1alpha and syndecan, are also processed by gamma-secretase...
  4. The Coordination of Netrin Signal Transduction
    Guofa Liu; Fiscal Year: 2011
    ..studying the coordination of signal transduction cascades downstream of different netrin receptors, for instance, DCC, DSCAM and UNC5. Aim 1. Determine the coordinating role of JNK1 in netrin signaling...
  5. Molecular Mechanisms Underlying Axon Pathfinding
    Wen Cheng Xiong; Fiscal Year: 2012
    ..Receptors for netrins involved in axon path-finding include DCC (deleted in colorectal cancer) and neogenin, a family of immunoglobin domain-containing proteins...
  6. AXON GUIDANCE IN THE SPINAL CORD
    Zaven Kaprielian; Fiscal Year: 2010
    ..segments of these axons, and an interaction between the cytoplasmic domains of Rob01 /2 and the Netrin receptor, DCC, silences Netrin attraction in vitro...
  7. Cynthia D Morris; Fiscal Year: 2016
    ..This research has great public health significance to potentially alter the fetal origins of respiratory disease by blocking some of the effects of in-utero smoke exposure on lung development. ..
  8. Analysis of the functions of axon guidance genes during vector mosquito developme
    MOLLY DUMAN SCHEEL; Fiscal Year: 2012
    ..of this investigation are to characterize the function of several axon guidance genes, including Netrin and its DCC receptor, and Semaphorin1a and its PlexinA receptor during mosquito development...
  9. HUA LINDA CAI; Fiscal Year: 2016
    ..whether netrin-1 is equally robust in inducing cardioprotection in vivo and whether the protection is mediated by a DCC-ERK1/2-deepdent activation of eNOS /nitric oxide (NO") in cardiac microvascular endothelial cells that should be ..
  10. George J Schwartz; Fiscal Year: 2016
    ..The CBL collaborates regularly with the Data Coordinating Center (DCC) to optimize GFR studies and to construct GFR estimating equations used during odd number visits at which no ..
  11. Barbara J Meyer; Fiscal Year: 2016
    ..We defined a protein complex (DCC) that binds both X chromosomes of XX animals to repress X expression by half...
  12. Molecular Mechanisms Regulating Axon Guidance Receptor Activity
    William G Wadsworth; Fiscal Year: 2013
    ..Several classes of guidance cues and receptors have been identified, including the UNC-6/netrin cue and the UNC-40/DCC receptor...
  13. Netrin signaling during neuronal development
    Elke Stein; Fiscal Year: 2010
    ..Netrin-1 attracts several classes of axons, while repelling others. Netrin receptors of the DCC family are implicated in mediating both attraction and repulsion;in contrast members of the UNC-5 family are ..
  14. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..sites in 13 states and territories and 9 international sites in Latin America, plus a Data Coordinating Center (DCC)...
  15. John G Flanagan; Fiscal Year: 2016
    ..Aim 1 builds on our recent work showing that the transmembrane axon guidance receptor DCC physically associates with translation initiation machinery, including eIFs and ribosomal subunits...
  16. EXTRACELLULAR MATRIX AND AXONAL GUIDANCE IN C. ELEGANS
    William Wadsworth; Fiscal Year: 2009
    ..act: (i) We found that in response to UNC-6/netrin and SLT-1/slit guidance cues the axon guidance receptor UNC-40/DCC is asymmetrically localized and recruits proteins such as MIG-10, which can promote axon outgrowth...
  17. Motor neuron migration regulated by guidance cues
    GRANT STEPHEN MASTICK; Fiscal Year: 2013
    ..by two opposing sets of guidance signals from the floor plate: repellent Slit/Robo signals and attractive Netrin/DCC signals...
  18. PITCH HF (CCC) Lead Application
    Marc J Semigran; Fiscal Year: 2013
    ..The CCC (Massachusetts General Hospital, PI: Marc Semigran MD) and the DCC (New England Research Institutes, PIs: Rebecca Li PhD;Susan Assmann PhD) provide extensive complementary expertise ..
  19. David Wypij; Fiscal Year: 2016
    ....
  20. PITCH HF (DCC)
    Flora Sandra Siami; Fiscal Year: 2013
    ..The CCC (Massachusetts General Hospital, PI: Marc Semigran MD) and the DCC (New England Research Institutes, PIs: Rebecca Li PhD;Susan Assmann PhD) provide extensive complementary expertise ..
  21. Kenneth Rosenfield; Fiscal Year: 2016
    ..by applicant): This resubmission is comprised of three applications (Clinical and Data Coordinating Centers (CCC, DCC) and Cost-Effectiveness Analysis Core)...
  22. JONATHAN MICHAEL DEAN; Fiscal Year: 2015
    ..The THAPCA Trials are studies that will determine whether whole body cooling of children who have had cardiac arrest will result in better survival and less brain injury. ..
  23. Northwest/Alaska/Hawaii Center to Reduce Oral Health Disparities
    PETER M MILGROM; Fiscal Year: 2012
    ..Toothbrushing with 1000 ppm Fluoride Toothpaste to Prevent ECC-and a Statistics and Data Coordinating Center (S&DCC)...
  24. Flora Sandra Siami; Fiscal Year: 2016
    ..by applicant): This resubmission is comprised of three applications (Clinical and Data Coordinating Centers (CCC, DCC) and Cost-Effectiveness Analysis Core)...
  25. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..the capabilities of our successful, commercially available monochromatic optics and doubly-curved crystal (DCC) optics to higher energy ranges than are currently possible...
  26. Study of Soy Isoflavones in Asthma (SOYA)
    Robert A Wise; Fiscal Year: 2013
    ..It is linked to the Data Coordinating Center (DCC) application submitted by Dr. Robert Wise from the Johns Hopkins Bloomberg School of Public Health...
  27. Study of Soy Isoflavones in Asthma (SOYA)
    Lewis J Smith; Fiscal Year: 2013
    ..It is linked to the Data Coordinating Center (DCC) application submitted by Dr. Robert Wise from the Johns Hopkins Bloomberg School of Public Health...
  28. MSI-FLASH: An Exercise Intervention for Women with Menopausal Symptoms
    Barbara Sternfeld; Fiscal Year: 2012
    ..The MSI-FLASH Data Coordinating Center (DCC) will be jointly led by Andrea LaCroix and Garnet Anderson who have served together as Co-Prinicpal Investigators ..
  29. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
    ..abstract_text> ..
  30. Judith E N Albino; Fiscal Year: 2016
    ..PhD, Professor, Colorado Health Outcomes Program, will lead the Statistics and Data Coordinating Center (S&DCC)...
  31. Gyorgyi Csankovszki; Fiscal Year: 2015
    ..worm Caenorhabditis elegans, dosage compensation is accomplished by a condensin-like dosage compensation complex (DCC), which binds both X chromosomes in XX hermaphrodites, to halve gene expression...
  32. Sandra E Juul; Fiscal Year: 2016
    ..The CCC will work closely with the linked DCC to accomplish the proposed goals...
  33. Patrick J Heagerty; Fiscal Year: 2016
    ..The CCC will work closely with the linked DCC to accomplish the proposed goals...
  34. Rule-Out Myocardial Infarction Using Computed Assisted Tomography-ROMICATII,DCC
    DAVID ALAN SCHOENFELD; Fiscal Year: 2012
    ..Optimally this study will provide professional societies with adequate information to justify recommendations on the use of cardiac CT (i.e. by issuing a class IA recommendation) in the ED evaluation of patients with acute chest pain. ..
  35. Robert J Glynn; Fiscal Year: 2016
    ..End of Abstract) ..
  36. Arthur J Moss; Fiscal Year: 2015
    ..Conducting such a trial might open the door to the development of an entire line of compounds targeting the late sodium current as their main mode of anti-arrhythmic action. ..
  37. Bonnie W Ramsey; Fiscal Year: 2016
    ..Previously unstudied characteristics of the respiratory microbiome predictive of poor microbiologic and/or clinical response will be identified. This CCC lead application is submitted with a DCC application.
  38. FUNCTIONAL STUDIES OF THE DCC TUMOR SUPPRESSOR GENE
    Eric Fearon; Fiscal Year: 1999
    ..The DCC (deleted in colorectal cancer) gene was identified and cloned on the basis of localized genetic alterations ..
  39. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
    ..Deleted in Colorectal Cancer [DCC] gene is a putative tumor suppressor gene...
  40. Nicole Mayer Hamblett; Fiscal Year: 2016
    ..Previously unstudied characteristics of the respiratory microbiome predictive of poor microbiologic and/or clinical response will be identified. This CCC lead application is submitted with a DCC application.
  41. A Data Analysis Center for integration of fly and worm modENCODE datasets
    Manolis Kellis; Fiscal Year: 2011
    ..Group (AWG), consisting of all Principal Investigators and analysis groups, and the Data Coordination Center (DCC), responsible for all data sharing within the consortium and with the larger worm and fly communities...
  42. Philip L Reed; Fiscal Year: 2015
    ..funded under Cooperative Agreements U10DD000007 and U01/DD000498 that established a Data Coordinating Center (DCC) for the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) at Michigan State ..
  43. Robert M Merion; Fiscal Year: 2016
    ..and maintain the Adult to Adult Living Donor Liver Transplantation Cohort Study Data Coordinating Center (A2ALL DCC) that will support a consortium of transplant centers in conducting continued observational and interventional ..
  44. JONATHAN MICHAEL DEAN; Fiscal Year: 2016
    ..The University of Utah is the Data Coordinating Center (DCC) for CPCCRN, and proposes to continue in this role during the next five years...
  45. DARYL T LAU; Fiscal Year: 2016
    ..In this proposal, by working collaboratively with the 10 clinical centers, the Data Coordinating Center (DCC), Virology Center, and Immunology Center within the NIH HBV network, we plan to (1)construct a prospective, ..
  46. Matthew W State; Fiscal Year: 2016
    ..Our Network involves six research sites and the AGRE DCC, collaborating in a systematic, comprehensive investigation of ASD genetics in order to identify rare mutations, ..
  47. JAMES EDWARD MITCHELL; Fiscal Year: 2015
    ..The NRI site, with the assistance of investigators at all the clinical sites and the DCC, has been instrumental in the development of the psychosocial, quality of life and eating behavior elements in LABS...
  48. DAVID BORREGO; Fiscal Year: 2015
    ..these reference fields to establish a rich library of organ doses per unit air kerma (dose conversion coefficients, DCC) across the entire UF adult phantom series...
  49. The West Virginia Smoking Cessation or Reduction in Pregnancy Treatment Trial
    RICHARD ANTHONY WINDSOR; Fiscal Year: 2010
    ..methods delivered by full-time public health staff- Designated Care Coordinators (DCCs);3) to document the routine DCC delivery rate and cost of the methods;and 4) to document DCC adoption predictors and the RFTS adoption rates of a ..
  50. Adrian Cotterell; Fiscal Year: 2014
    ..The GR2HCC is nested in 6 of the 9 patient enrolling transplant centers of A2ALL utilizing the DCC of A2ALL for data collection and analysis and the Division of Cancer Epidemiology and Genetics of the National ..
  51. Steven R Brant; Fiscal Year: 2016
    ..multicenter collaborative studies of 6 Genetics Research Centers (GRCs) organized with a Data Coordinating Center (DCC)...
  52. Clinical Outcomes of Live Organ Donors - Data Coordinating Center
    Robert M Merion; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): We propose to develop and maintain a Data Coordinating Center (DCC) that will support a consortium of transplant centers (Clinical Centers) by conducting epidemiological research on the medical and ..
  53. A Comprehensive Approach to Identification of Autism Susceptibility Genes
    Daniel H Geschwind; Fiscal Year: 2012
    ..This collaborative network application involving six research sites and the AGRE DCC, will systematically and comprehensively investigate the genetics of ASD to identify rare mutations, chromosomal ..
  54. Linking dosage compensation complex assembly to X chromosome gene regulation
    BAYLY SIMPSON WHEELER; Fiscal Year: 2013
    ..To enact DC in C. elegans, a dosage compensation complex (DCC) is recruited to the X chromosome by recruitment elements, caled rex sites...
  55. COPD Clinical Research Network - Data Coordinating Center
    John E Connett; Fiscal Year: 2011
    ..Divisions of Epidemiology and Pulmonary Medicine, proposes to establish and operate the Data Coordinating Center (DCC) for the Chronic Obstructive Pulmonary Disease Clinical Research Network...
  56. Stroke with Transfusions Changing to Hydroxyurea (SWITCH) Trial Data Coordinating
    Ronald W Helms; Fiscal Year: 2010
    ..and this proposal to fund the SWiTCH Data Coordinating Center (DCC)...
  57. David M Miller; Fiscal Year: 2016
    ..is captured at the tips of PVD dendrites to mediate self-avoidance in a pathway involving the receptors UNC-40/DCC and UNC-5...
  58. Frequent Hemodialysis Network - West Coast Consortium
    GLENN MATTHEW CHERTOW; Fiscal Year: 2010
    ..The consortium has worked effectively with multiple industry partners. We are collectively committed to working cooperatively and constructively with the other CCC and DCC to reach all FHN study goals.
  59. Lemuel A Moye; Fiscal Year: 2016
    ..cell processing quality control laboratory (CP-QCL);five core laboratories;the NHLBI Project Office;and the DCC which provides Network trial management and data analyses...
  60. DCC--INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUP
    J Landis; Fiscal Year: 2003
    ..and Biostatistics (CCEB) at the University of Pennsylvania Medical Center to serve as the Data Coordinating Center (DCC) for the Interstitial Cystitis Clinical Trials Group (ICCTG)...
  61. Dialysis Access Consortium Data Coordinating Center
    Gerald Beck; Fiscal Year: 2007
    The Data Coordinating Center (DCC) for the Dialysis Access Consortium (DAC) will coordinate the scientific and operational aspects of the two on-going DAC randomized placebo controlled clinical trials: the Fistula Trial and the Graft ..
  62. MABS TO TUMOR SUPPRESSOR GENE DCC-ENCODED PROTEIN
    CHUNMING HUANG; Fiscal Year: 1992
    ..The tumor suppressor genes Rb,p53,WT1,NF-1,DCC and MCC have been cloned...
  63. COLON CELL DIFFERENTIATION--DCC ROLE IN MUC2 EXPRESSION
    Leonard Augenlicht; Fiscal Year: 2000
    The DCC gene is a potential tumor suppressor gene whose deletion or inactivation plays a role in colonic tumor progression...
  64. Frequent Hemodialysis Network Data Coordinating Center
    Gerald J Beck; Fiscal Year: 2010
    The Data Coordinating Center (DCC) for the Frequent Hemodialysis Network (FHN) will continue to coordinate the scientific and operational aspects of the two FHN clinical trials: one comparing short in-center 6x/week dialysis with ..