DAX 1

Summary

Gene Symbol: DAX 1
Description: nuclear receptor subfamily 0 group B member 1
Alias: AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2, nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, nuclear hormone receptor, nuclear receptor DAX-1
Species: human

Top Publications

  1. ncbi Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis
    W Guo
    Department of Pediatrics, UCLA School of Medicine 90024, USA
    Biochem Mol Med 56:8-13. 1995
  2. ncbi DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
    E Zazopoulos
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP BP 163, Strasbourg, France
    Nature 390:311-5. 1997
  3. ncbi An alternate translation initiation site circumvents an amino-terminal DAX1 nonsense mutation leading to a mild form of X-linked adrenal hypoplasia congenita
    Gokhan Ozisik
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    J Clin Endocrinol Metab 88:417-23. 2003
  4. pmc CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease
    Bruno Ferraz-de-Souza
    Developmental Endocrinology Research Group, University College London Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 94:678-83. 2009
  5. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
  6. pmc Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
  7. pmc LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1
    Taiga Suzuki
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Cell Biol 23:238-49. 2003
  8. ncbi Distinct repressive properties of the mammalian and fish orphan nuclear receptors SHP and DAX-1
    Yun Yong Park
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Korea
    Mol Cells 23:331-9. 2007
  9. doi DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing
    Kenji Ohe
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Dev Dyn 238:1595-604. 2009
  10. ncbi Identification of a putative steroidogenic factor-1 response element in the DAX-1 promoter
    T P Burris
    Department of Pediatrics, UCLA School of Medicine 90024, USA
    Biochem Biophys Res Commun 214:576-81. 1995

Research Grants

  1. CAM Curriculum Project
    Mary Jo Kreitzer; Fiscal Year: 2004
  2. Vincent W Yang; Fiscal Year: 2016
  3. Yatrik M Shah; Fiscal Year: 2016
  4. Lori A Coburn; Fiscal Year: 2016
  5. Keith T Wilson; Fiscal Year: 2016
  6. A novel agent suppresses colitis and colon cancer
    Nengtai Ouyang; Fiscal Year: 2013
  7. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
  8. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
  9. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
  10. Dezheng Zhao; Fiscal Year: 2016

Detail Information

Publications464 found, 100 shown here

  1. ncbi Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis
    W Guo
    Department of Pediatrics, UCLA School of Medicine 90024, USA
    Biochem Mol Med 56:8-13. 1995
    DAX-1, an orphan member of the nuclear hormone receptor superfamily, is responsible for X-linked adrenal hypoplasia congenita (AHC) and the frequently associated hypogonadotropic hypogonadism (HH)...
  2. ncbi DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
    E Zazopoulos
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP BP 163, Strasbourg, France
    Nature 390:311-5. 1997
    ..Our results establish DAX-1 as the first member of the nuclear receptor superfamily with novel DNA-binding features and reveal that it has regulatory properties critical to the understanding of its physiological functions...
  3. ncbi An alternate translation initiation site circumvents an amino-terminal DAX1 nonsense mutation leading to a mild form of X-linked adrenal hypoplasia congenita
    Gokhan Ozisik
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    J Clin Endocrinol Metab 88:417-23. 2003
    Mutations in DAX1 [dosage-sensitive sex reversal-adrenal hypoplasia congenita (AHC) critical region on the X chromosome gene 1; NR0B1] cause X-linked AHC, a disease characterized by primary adrenal failure in infancy or childhood and ..
  4. pmc CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease
    Bruno Ferraz-de-Souza
    Developmental Endocrinology Research Group, University College London Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 94:678-83. 2009
    ..Disorders of adrenal development result in significant morbidity and mortality. However, the molecular basis of human adrenal development, and many forms of disease, is still poorly understood...
  5. ncbi Down-regulation of steroidogenic response to gonadotropins in human and rat preovulatory granulosa cells involves mitogen-activated protein kinase activation and modulation of DAX-1 and steroidogenic factor-1
    Kimihisa Tajima
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 71600, Israel
    J Clin Endocrinol Metab 88:2288-99. 2003
    ..Moreover, modulation of DAX-1 and SF-1 intracellular levels in these cells suggests that these transcription factors could be involved in MAPK suppression of StAR expression...
  6. pmc Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis
    Bin Xu
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan 48109 5678, USA
    Mol Cell Biol 29:1719-34. 2009
    ..These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology...
  7. pmc LXXLL-related motifs in Dax-1 have target specificity for the orphan nuclear receptors Ad4BP/SF-1 and LRH-1
    Taiga Suzuki
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Cell Biol 23:238-49. 2003
    ..Taken together, our results indicate that the specificities of LXXLL-related motifs in Dax-1 based on their amino acid sequences play an important role in regulation of orphan receptors...
  8. ncbi Distinct repressive properties of the mammalian and fish orphan nuclear receptors SHP and DAX-1
    Yun Yong Park
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Korea
    Mol Cells 23:331-9. 2007
    ..nile tilapia (Oreochromis niloticus) small heterodimer partner (nSHP/NR0B2) and the Dosage-sensitive sex reversal AHC critical region on X chromosome gene 1 (nDAX-1/NR0B1) with those of human SHP and DAX-1 (hSHP and hDAX-1, ..
  9. doi DAX-1 and SOX6 molecular interplay results in an antagonistic effect in pre-mRNA splicing
    Kenji Ohe
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Strasbourg, France
    Dev Dyn 238:1595-604. 2009
    DAX-1 (DSS-AHC Critical Region on the X Chromosome-1) is a member of the nuclear hormone receptor superfamily that has an important role in steroidogenesis and gonadogenesis...
  10. ncbi Identification of a putative steroidogenic factor-1 response element in the DAX-1 promoter
    T P Burris
    Department of Pediatrics, UCLA School of Medicine 90024, USA
    Biochem Biophys Res Commun 214:576-81. 1995
    The nuclear hormone receptor, DAX-1, is responsible for X-linked adrenal hypoplasia congenita and hypogonadotrophic hypogonadism...
  11. ncbi A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita
    E Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch Strasbourg, France
    Mol Endocrinol 11:1950-60. 1997
    The DAX-1 gene encodes an unusual member of the nuclear hormone receptor superfamily. Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita associated with hypogonadotropic hypogonadism...
  12. ncbi Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita
    B Altincicek
    Genetisches Institut, Justus Liebig Universitat, Heinrich Buff Ring 58 62, Giessen D 35392, Germany
    J Biol Chem 275:7662-7. 2000
    DAX-1 is an unusual member of the nuclear hormone receptor (NHR) superfamily. Lack of DAX-1-mediated silencing leads to adrenal hypoplasia congenita and hypogonadotropic hypogonadism...
  13. pmc Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA
    E Lalli
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, Illkirch Strasbourg, France
    Mol Cell Biol 20:4910-21. 2000
    The DAX-1 (NR0B1) gene encodes an unusual member of the nuclear hormone receptor superfamily which acts as a transcriptional repressor...
  14. ncbi Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle
    Yoko Sato
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 88:3415-20. 2003
    ..These results indicated that DAX-1 and COUP-TFII may play a role in the modulation of Ad4BP/SF-1-dependent transcription of steroidogenic enzymes in different cell types and follicular stages in normal cycling human ovaries...
  15. ncbi Differential role of the loop region between helices H6 and H7 within the orphan nuclear receptors small heterodimer partner and DAX-1
    Yun Yong Park
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Endocrinol 18:1082-95. 2004
    ..nuclear receptors small heterodimer partner (SHP) and dosage-sensitive sex-reversal adrenal hypoplasia congenital (AHC) critical region on the X chromosome gene 1 (DAX-1) contain extra amino acids between helices H6 and H7 of LBD, and ..
  16. ncbi Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing
    Anwar Hossain
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Mol Endocrinol 18:1428-37. 2004
    ....
  17. pmc The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1
    Elena P Sablin
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 105:18390-5. 2008
    ..The structure of the Dax-1:LRH-1 complex provides the molecular mechanism for the function of Dax-1 as a potent transcriptional repressor...
  18. pmc E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis
    Anna Ehrlund
    Department of Biosciences and Nutrition, Karolinska Institutet, S 14157 Huddinge Stockholm, Sweden
    Mol Cell Biol 29:2230-42. 2009
    ....
  19. pmc DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression
    Balachandar Nedumaran
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, South Korea
    J Biol Chem 284:27511-23. 2009
    ..Overall, this study demonstrates that DAX-1 acts as a corepressor of HNF4alpha to negatively regulate hepatic gluconeogenic gene expression in liver...
  20. ncbi A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal
    B Bardoni
    Universita di Pavia, Italy
    Nat Genet 7:497-501. 1994
    ..We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the ..
  21. ncbi An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita
    E Zanaria
    Universita di Pavia, Italy
    Nature 372:635-41. 1994
    ..DAX-1 encodes a new member of the nuclear hormone receptor superfamily displaying a novel DNA-binding domain...
  22. ncbi Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
    F Muscatelli
    ICRF Laboratories, John Radcliffe Hospital, Oxford, UK
    Nature 372:672-6. 1994
    ..DSS-AHC critical region on the X, gene 1) gene was isolated and found to encode a new member of the nuclear hormone receptor family...
  23. pmc A novel mutation in DAX1 causes delayed-onset adrenal insufficiency and incomplete hypogonadotropic hypogonadism
    A Tabarin
    Departement d Endocrinologie, Diabétologie du CHU de Bordeaux, USN Haut Lévêque, 33604 Pessac, France
    J Clin Invest 105:321-8. 2000
    Mutations in the DAX1 gene cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HHG)...
  24. ncbi Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1
    Elin Holter
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    Mol Endocrinol 16:515-28. 2002
    DAX-1 (NROB1) is an atypical member of the nuclear receptor family that is predominantly expressed in mammalian reproductive tissues...
  25. pmc Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience
    Lin Lin
    UCL Institute of Child Health and Department of Medicine, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 91:3048-54. 2006
    ..The nuclear receptors DAX1 (NR0B1) and steroidogenic factor-1 (SF1/Ad4BP, NR5A1) play an important role in adrenal development and function, ..
  26. doi Seven novel DAX1 mutations with loss of function identified in Chinese patients with congenital adrenal hypoplasia
    Na Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 95:E104-11. 2010
    ..sex reversal, adrenal hypoplasia congenital critical region on the X chromosome, gene 1; also called NROB1) mutations are responsible for adrenal failure and hypogonadotropic hypogonadism in patients with adrenal ..
  27. ncbi Active hypothalamic-pituitary-gonadal axis in an infant with X-linked adrenal hypoplasia congenita
    T Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    J Pediatr 130:485-8. 1997
    ..We speculate that sometime between infancy and puberty this mutation in the DAX-1 gene leads to an inability to activate the reproductive axis from its childhood suppression; thus puberty will not develop in this infant...
  28. ncbi Dax1 antagonizes Sry action in mammalian sex determination
    A Swain
    Division of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Nature 391:761-7. 1998
    b>DAX1, which encodes an unusual member of the nuclear hormone-receptor superfamily, is a gene that may be responsible for a sex-reversal syndrome in humans, referred to as dosage-sensitive sex reversal, in which XY individuals carrying ..
  29. ncbi Combined hypothalamic-pituitary-gonadal defect in a hypogonadic man with a novel mutation in the DAX-1 gene
    P Caron
    Service d Endocrinologie et Maladies Métaboliques, CHU Rangueil, Toulouse, France
    J Clin Endocrinol Metab 84:3563-9. 1999
    ..In conclusion, we report a novel mutation in the DAX-1 gene in patients with AHC and HH...
  30. ncbi DAX-1 functions as an LXXLL-containing corepressor for activated estrogen receptors
    H Zhang
    Department of Biosciences at Novum, Karolinska Institute, S 14157 Huddinge, Sweden
    J Biol Chem 275:39855-9. 2000
    We have discovered that the orphan receptor DAX-1 (NROB1) interacts with the estrogen receptors ERalpha and ERbeta...
  31. ncbi Phenotypic spectrum of mutations in DAX-1 and SF-1
    J C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Tarry Building, 15 709, Chicago, IL 60611, USA
    Mol Cell Endocrinol 185:17-25. 2001
    ..Targeted mutagenesis of Dax1 (Ahch) in mice reveals an additional role in testis development and spermatogenesis...
  32. ncbi Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita
    Giovanna Mantovani
    Institute of Endocrine Sciences, Inc, Ospedale Maggiore IRCCS and Istituto Auxologico Italiano, 20122 Milan, Italy
    J Clin Endocrinol Metab 87:44-8. 2002
    ..This case demonstrates that partial loss-of-function mutations in DAX1 can present with hypogonadotropic hypogonadism and covert adrenal failure in adulthood...
  33. ncbi Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation
    Pamela Brown
    Medical Research Council Human Reproductive Sciences Unit, Center for Reproductive Biology, University of Edinburgh, United Kingdom
    J Clin Endocrinol Metab 88:1341-9. 2003
    Mutations in the DAX-1 (NROB1) gene result in X-linked congenital adrenal hypoplasia (AHC) and hypogonadotropic hypogonadism...
  34. pmc DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-alpha, ER-beta and androgen receptor status
    Isabel Conde
    Department of Cell Biology and Genetics, University of Alcala, Alcala de Henares, Madrid, Spain
    Breast Cancer Res 6:R140-8. 2004
    ....
  35. ncbi Orphan nuclear receptor DAX-1 in human endometrium and its disorders
    Sumika Saito
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendia 980 8575, Japan
    Cancer Sci 96:645-52. 2005
    ....
  36. ncbi DAX1 and X-linked adrenal hypoplasia congenita: clinical and molecular analysis in five patients
    Giovanna Mantovani
    Institute of Endocrine Sciences, University of Milan, Padiglione Granelli, Ospedale Maggiore IRCCS, Via F Sforza 35, 20122 Milan, Italy
    Eur J Endocrinol 154:685-9. 2006
    Mutations in the gene coding for the orphan nuclear receptor DAX1 cause X-linked adrenal hypoplasia congenita (AHC). Affected boys usually present with primary adrenal failure in early infancy or childhood...
  37. ncbi Nuclear receptor DAX1 in human prostate cancer: a novel independent biological modulator
    Yasuhiro Nakamura
    Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Endocr J 56:39-44. 2009
    The orphan nuclear receptor DAX1 (dosage-sensitive sex reversal-AHC critical region on the X chromosome gene 1; NR0B1) has been known for its various roles in human development, specifically sex determination and steroidogenesis...
  38. doi Clinical and genetic heterogeneity of congenital adrenal hypoplasia due to NR0B1 gene mutations
    Zohar Landau
    Division of Pediatric Endocrinology, E Wolfson Medical Center, Holon and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Endocrinol (Oxf) 72:448-54. 2010
    X-linked adrenal hypoplasia congenita (AHC) is a rare disorder caused by mutations or complete deletion of the NR0B1 gene that encodes the DAX-1 protein, an orphan member of the nuclear receptor superfamily...
  39. pmc Birth after TESE-ICSI in a man with hypogonadotropic hypogonadism and congenital adrenal hypoplasia linked to a DAX-1 (NR0B1) mutation
    C Frapsauce
    UPMC, AP HP, Hopital Tenon, Service de Biologie de la Reproduction, 75020 Paris, France
    Hum Reprod 26:724-8. 2011
    b>DAX1/NR0B1 mutations are responsible for X-linked congenital adrenal hypoplasia (AHC) associated with hypogonadotropic hypogonadism (HH). Few data are available concerning testicular function and fertility in men with DAX1 mutations...
  40. ncbi The prognostic value of the orphan nuclear receptor DAX-1 (NROB1) in node-negative breast cancer
    Hui Zhang
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Anticancer Res 31:443-9. 2011
    ..DAX-1 inhibits oestrogen receptor (ER) activities and aromatase P450 expression. The prognostic effect of DAX-1 expression in breast cancer was investigated...
  41. ncbi RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1
    T Sugawara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Hokkaido 060 8638, Japan
    Endocrinology 142:3570-7. 2001
    ..We conclude that RIP 140 binds to the orphan nuclear receptor SF-1 and DAX-1 and modulates their actions on the human steroidogenic acute regulatory protein promoter...
  42. ncbi DAX-1 represses the high-density lipoprotein receptor through interaction with positive regulators sterol regulatory element-binding protein-1a and steroidogenic factor-1
    D Lopez
    Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
    Endocrinology 142:5097-106. 2001
    ....
  43. ncbi An atypical kindred with X-linked adrenal hypoplasia congenita, normal puberty, and normal Dax-1 promoter and coding sequence
    K Y Loke
    Department of Paediatrics, National University of Singapore
    J Pediatr Endocrinol Metab 13:29-36. 2000
    ....
  44. pmc Novel receptor interaction and repression domains in the orphan receptor SHP
    W Seol
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Mol Cell Biol 17:7126-31. 1997
    ..orphan receptor that lacks a conventional DNA binding domain and interacts with other members of the nuclear hormone receptor superfamily...
  45. ncbi Diagnosis of X-linked adrenal hypoplasia congenita by mutation analysis of the DAX1 gene
    W Guo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex, USA
    JAMA 274:324-30. 1995
    ..congenita (AHC) and hypogonadotropic hypogonadism (HH) due to mutations in DAX1, a new member of the nuclear hormone receptor gene superfamily...
  46. pmc Aromatase (Cyp19) expression is up-regulated by targeted disruption of Dax1
    Z J Wang
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 98:7988-93. 2001
    ..Mutations in the human DAX1 gene (also known as AHC) cause the X-linked syndrome AHC, a disorder that is associated with hypogonadotropic ..
  47. ncbi Frequent association of alternative splicing of NER, a nuclear hormone receptor gene in cancer tissues
    H Saito
    Department of Human Genome Analysis, Cancer Institute, Toshima-ku, Tokyo, Japan
    Oncogene 14:617-21. 1997
    ..This observation may imply that the aberrant NER product has some relation to the development and/or progression of cancers in a variety of human tissues...
  48. ncbi Advances in the molecular genetics of hypogonadotropic hypogonadism
    J C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    J Pediatr Endocrinol Metab 14:3-15. 2001
    ..Here, we consider mutations in KAL in X-linked Kallmann syndrome; DAX1 in X-linked adrenal hypoplasia congenita; the related orphan nuclear receptor, steroidogenic factor-1; leptin and ..
  49. ncbi Mutational analysis of DAX1 in patients with hypogonadotropic hypogonadism or pubertal delay
    J C Achermann
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 84:4497-500. 1999
    ..Mutations in another gene, DAX1 (AHC), cause X-linked adrenal hypoplasia congenita and HH...
  50. ncbi Expression of Dax-1 during gonadal development of the frog
    J Sugita
    Department of Biology, School of Education, Waseda University, 1-6-1 Nishi-Waseda, Shinjuku-ku, Tokyo 169-8050, Japan
    Gene 280:67-74. 2001
    Dax-1, a member of the nuclear hormone receptor superfamily of transcription factors, is known to be involved in gonadal development in mammals. To date, Dax-1 has only been isolated in reptiles, birds and mammals...
  51. ncbi DAX1 gene expression upregulated by steroidogenic factor 1 in an adrenocortical carcinoma cell line
    E Vilain
    Department of Pediatrics, University of California Los Angeles School of Medicine 90095 1752, USA
    Biochem Mol Med 61:1-8. 1997
    Two nuclear hormone receptor superfamily members, DAX1 and SF1, are required for normal adrenal cortical development. Mutations in DAX1 are responsible for X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism...
  52. ncbi Congenital adrenal hypoplasia and DAX-1 gene mutations
    A Tabarin
    , , 33604 Pessac, France
    Ann Endocrinol (Paris) 62:202-6. 2001
    DAX-1 is a member of the orphan nuclear hormone receptor family...
  53. ncbi SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expre
    C Aigueperse
    , , , France
    Mol Endocrinol 15:93-111. 2001
    ..Taken together, our findings suggest that detoxifying enzymes of the aldose reductase family may constitute new potential targets for regulators of adrenal and gonadal differentiation and function, e.g. SF-1 and DAX-1...
  54. ncbi Role of phosphorylation, gene dosage and Dax-1 in SF-1 mediated steroidogenesis
    P S Babu
    Internal Medicine and Physiology, University of Michigan, Ann Arbor 48109-0678, USA
    Endocr Res 26:985-94. 2000
    ..Mice that express epitope tagged SF-1 (wild type, SF-1S203A and SF-1S203D) are being used to rescue the heterozygous adrenal phenotype and to determine the in vivo role of SF-1 phosphorylation in adrenal function...
  55. ncbi Transcriptional regulation of the human FTZ-F1 gene encoding Ad4BP/SF-1
    K Oba
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi Higashi-ku, Fukuoka 812-8582, Japan
    J Biochem 128:517-28. 2000
    ....
  56. ncbi Abnormalities of sex differentiation
    H Nawata
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Res 46:15-9. 1996
    ..The molecular bases of cases clinically reported as 17 alpha-hydroxylase deficiency have turned out to be complete or partial combined deficiencies of 17 alpha-hydroxylase/17,20-lyase...
  57. ncbi Nuclear receptor Dax-1 represses the transcriptional cooperation between GATA-4 and SF-1 in Sertoli cells
    J J Tremblay
    Ontogeny and Reproduction Research Unit, CHUL Research Centre and Centre for Research in Biology of Reproduction, Department of Obstetrics and Gynecology, Laval University, Ste-Foy, , Canada G1V 4G2
    Biol Reprod 64:1191-9. 2001
    ....
  58. ncbi Functional assessment of the calcium messenger system in cultured mouse Leydig tumor cells: regulation of human chorionic gonadotropin-induced expression of the steroidogenic acute regulatory protein
    P R Manna
    Department of Physiology, Institute of Biomedicine, University of Turku, Finland
    Endocrinology 140:1739-51. 1999
    ..The stimulatory effect of hCG that rapidly increases [Ca2+]i is responsible at least in part for the regulation of SF-1-mediated StAR expression that consequently regulates steroidogenesis in mouse Leydig tumor cells...
  59. ncbi Mutations in NR0B1 (DAX1) and NR5A1 (SF1) responsible for adrenal hypoplasia congenita
    J K Phelan
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, California 90095-1752, USA
    Hum Mutat 18:472-87. 2001
    ..The predominant adrenal hypoplasia congenita locus, however, is the NR0B1 gene, at Xp21, encoding the protein DAX1. In this article, we present a compendium of published NR0B1 mutations and polymorphisms, and discuss them in the ..
  60. pmc Deletion mapping and X inactivation analysis of a non-specific mental retardation gene at Xp21.3-Xp22.11
    K Muroya
    Department of Paediatrics, Keio University School of Medicine, Tokyo, Japan
    J Med Genet 36:187-91. 1999
    ....
  61. ncbi Genetics of human hypogonadotropic hypogonadism
    L C Layman
    Section of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912-3360, USA
    Am J Med Genet 89:240-8. 1999
    ..Mutations in the KAL gene (Kallmann syndrome) and the AHC gene (adrenal hypoplasia congenita/HH) cause X-linked recessive HH...
  62. ncbi DAX-1 blocks steroid production at multiple levels
    E Lalli
    , Centre National de la Recherche Scientifique, , , Strasbourg, France
    Endocrinology 139:4237-43. 1998
    DAX-1 is an unusual member of the nuclear hormone receptor superfamily whose expression is mainly, but not uniquely, restricted to steroidogenic tissues...
  63. ncbi Sex determining gene on the X chromosome short arm: dosage sensitive sex reversal
    T Ogata
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Acta Paediatr Jpn 38:390-8. 1996
    The present review article summarizes current knowledge concerning the sex determining gene on Xp21, termed DSS (dosage sensitive sex reversal)...
  64. ncbi DAX-1 gene mutations and deletions in Japanese patients with adrenal hypoplasia congenita and hypogonadotropic hypogonadism
    E Kinoshita
    Department of Pediatrics, Nagasaki University School of Medicine, Japan
    Horm Res 48:29-34. 1997
    ..The DAX-1 gene was entirely deleted in a 3rd patient as well as in a 4th with the additional feature of glycerol kinase deficiency...
  65. ncbi Mammalian sex determination: from gonads to brain
    E Vilain
    Department of Human Genetics, UCLA School of Medicine and UCLA Children's Hospital, Los Angeles, California, 90095-1752, USA
    Mol Genet Metab 65:74-84. 1998
    ..These genes are WT1, SF1, DAX1, and SOX9...
  66. ncbi [Recent progress in the research field of nuclear receptors]
    H Nawata
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
    Nippon Rinsho 55:2160-7. 1997
    ..Furthermore, there have been more than sixty orphan receptors identified in these eight years, including HNF, Ad4BP, DAX-1, and nur77/NGFIB, some of which are mutation target genes of human congenital diseases...
  67. ncbi Protein coregulators that mediate estrogen receptor function
    T Ratajczak
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Reprod Fertil Dev 13:221-9. 2001
    ..time as intensive research is revealing the role played by downstream coregulator proteins in linking nuclear hormone receptor activity to general transcription machinery involved in gene transcriptional activation...
  68. ncbi Minipuberty of infancy and adolescent pubertal function in adrenal hypoplasia congenita
    K B Kaiserman
    Department of Pediatrics, UCLA Children's Hospital 90095-1752, USA
    J Pediatr 133:300-2. 1998
    An infant and his uncle, both with adrenal hypoplasia congenita, shared the same DAX1 mutation. The adolescent uncle had hypogonadotropic hypogonadism, but the infant had a normal minipuberty of infancy...
  69. ncbi Development and characteristics of a new strain of obese hyperinsulinemic and hyperlipidemic Dahl salt-sensitive rat. The Dahl salt-sensitive/NIH-corpulent rat
    O E Michaelis
    Beltsville Human Nutrition Research Center, ARS, USDA, MD 20705, USA
    Am J Hypertens 8:467-73. 1995
    A new congenic rat strain, the Dahl salt-sensitive/NIH-corpulent (DSS/N-cp) rat, has been developed to study the role of obesity and type of dietary carbohydrate in the development of hypertension and its complications...
  70. ncbi Affinity chromatography of human estrogen receptor-alpha expressed in Saccharomyces cerevisiae. Combination of heparin- and 17beta-estradiol-affinity chromatography
    W Feng
    Institute for Applied Microbiology, University of Agricultural Sciences, Vienna, Austria
    J Chromatogr A 852:161-73. 1999
    Estrogen receptor-alpha is a member of the nuclear hormone receptor superfamily and is considered as a very important regulatory protein...
  71. ncbi Aberrant crypt foci in the colonic mucosa of rats treated with a genotoxic and nongenotoxic colon carcinogen
    L O Whiteley
    Procter and Gamble, Cincinnati, Ohio 45253, USA
    Toxicol Pathol 24:681-9. 1996
    ..Six-wk-old Fischer-344 rats were administered dextran sulfate (DSS, nongenotoxin) in the drinking water or azoxymethane (AOM, genotoxin) by single subcutaneous injection...
  72. pmc Immunomodulation in the treatment of multiple sclerosis and amyotrophic lateral sclerosis: a model for autoimmune disorders
    K Alonso
    Institute for Advanced Studies in Medicine, Atlanta, Georgia, USA
    J Natl Med Assoc 87:561-8. 1995
    ..therapy (average treatment duration: 3 years) with performance status 3-4 (mean Disability Status Scale [DSS]: 82) who demonstrated circulating lymphokine inhibitor factors were selected for a monthly immunomodulatory ..
  73. ncbi Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1
    C Dorn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 274:13870-6. 1999
    ..We conclude that the synergy between Egr-1 and SF-1 is essential for GnRH stimulation of the LHbeta gene and plays a central role in the dynamic regulation of LHbeta expression...
  74. ncbi Serum cytokines in gestational trophoblastic diseases
    M Shaarawy
    Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt
    Acta Oncol 34:177-82. 1995
    ..and TNF-alpha assays are valuable biomarkers in the differential diagnosis of gestational trophoblastic disease (GTD)...
  75. ncbi Congenital adrenal hypoplasia: clinical spectrum, experience with hormonal diagnosis, and report on new point mutations of the DAX-1 gene
    M Peter
    Department of Pediatrics, Christian Albrechts University, Kiel, Germany
    J Clin Endocrinol Metab 83:2666-74. 1998
    ..cortex and is caused by deletion or mutation of the DAX-1 gene, a recently discovered member of the nuclear hormone receptor superfamily. Hypogonadotropic hypogonadism is frequently associated with AHC...
  76. pmc The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation
    J Kim
    Department of Biochemistry, Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 19:2289-99. 1999
    ..In addition, we demonstrate that WT1 can activate the endogenous Dax-1 promoter. Our results indicate that the WT1-DAX-1 pathway is an early event in the process of mammalian sex determination...
  77. ncbi Molecular basis governing primary sex in mammals
    K Nagai
    Department of Biochemistry, Tokyo Medical College, Japan
    Jpn J Hum Genet 41:363-79. 1996
    ..Further, several autosomal genes, such as SF1, WT1, SOX and MIS, as well as a unique X chromosomal DAX1 were suggested to be associated with the development of gonadal sex in mammals...
  78. ncbi Genetic control of gonadal differentiation
    H N Lim
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, UK
    Baillieres Clin Endocrinol Metab 12:1-16. 1998
    ..Subsequent sex-specific gonadal differentiation appears to be mediated by the SRY and SOX9 genes in the testis, and the DAX-1 gene in the ovary...
  79. ncbi Growth hormone deficiency due to traumatic brain injury in a patient with X-linked congenital adrenal hypoplasia
    Ozlem Engiz
    Division of Pediatric Endocrinology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Turk J Pediatr 52:312-6. 2010
    X-linked adrenal hypoplasia congenita (AHC) is characterized by primary adrenal insufficiency and is frequently associated with hypogonadotropic hypogonadism (HH)...
  80. doi Late-onset adrenal hypoplasia congenita caused by a novel mutation of the DAX-1 gene
    Fan Yang
    Division of Pediatrics and Perinatology, Faculty of Medicine, Tottori University, Yonago, 683 8504, Japan
    Eur J Pediatr 168:329-31. 2009
    Mutation in the orphan nuclear receptor DAX-1 gene causes X-linked adrenal hypoplasia congenita (AHC)...
  81. ncbi DAX-1 expression in human adrenocortical neoplasms: implications for steroidogenesis
    M Reincke
    Department of Medicine II, University of Freiburg, FRG
    J Clin Endocrinol Metab 83:2597-600. 1998
    The DAX-1 gene encodes an orphan nuclear hormone receptor essential for normal fetal development of the adrenal cortex...
  82. ncbi Expression of three negative regulators of CYP17 gene transcription in adrenocortical cells
    T Lehmann
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
    Endocr Res 26:1019-26. 2000
    ..Our results suggest that in the adrenocortical cells in culture, the expression of DAX1 and COUP-TF is constitutive, whereas N-CoR expression might be inducible.
  83. ncbi Dax1 regulates testis cord organization during gonadal differentiation
    Joshua J Meeks
    Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Development 130:1029-36. 2003
    Mutations of the DAX1 nuclear receptor gene cause adrenal hypoplasia congenita, an X-linked disorder characterized by adrenal insufficiency and hypogonadotropic hypogonadism...
  84. ncbi Practice patterns for prostate cancer in nine central and northern Italy radiation oncology centers: a survey including 1759 patients treated during two decades (1980-1998)
    Stefano Maria Magrini
    Department of Radiation Oncology, Istituto del Radio, O Alberti Brescia University, Brescia, Italy
    Int J Radiat Oncol Biol Phys 52:1310-9. 2002
    ....
  85. ncbi Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita
    A T Reutens
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 84:504-11. 1999
    Adrenal hypoplasia congenita (AHC) is an X-linked disorder caused by mutations in a gene referred to as DAX-1. AHC is characterized by adrenal insufficiency and failure to undergo puberty because of hypogonadotropic hypogonadism...
  86. pmc Can clinical trials requiring frequent participant contact be conducted over the Internet? Results from an online randomized controlled trial evaluating a topical ointment for herpes labialis
    Margaret Formica
    Division of Rheumatology, Tufts New England Medical Center, Box 406, 750 Washington Street, Boston, MA 02111, USA
    J Med Internet Res 6:e6. 2004
    ..An Internet-based randomized clinical trial design may reduce this burden, permitting frequent symptom reports with considerably less effort...
  87. pmc Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    BMC Cancer 7:84. 2007
    ....
  88. pmc The first major outbreak of dengue hemorrhagic fever in Delhi, India
    L Dar
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Emerg Infect Dis 5:589-90. 1999
    India An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHS/DSS) occurred in 1996 in India in and near Delhi...
  89. ncbi Activation of toll-like receptor 3 protects against DSS-induced acute colitis
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 13:856-64. 2007
    ....
  90. ncbi Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation
    H S Cooper
    Department of Pathology, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Carcinogenesis 21:757-68. 2000
    ..the histopathology and inflammation scores as they relate to dysplasia and cancer in the dextran sulfate sodium (DSS) colitis model...
  91. pmc Protective and enhancing HLA alleles, HLA-DRB1*0901 and HLA-A*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
    Thi Phuong Lan Nguyen
    Department of Immunogenetics, Institute of Tropical Medicine NEKKEN, Nagasaki University, Japan
    PLoS Negl Trop Dis 2:e304. 2008
    ..Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam...
  92. ncbi X-linked congenital adrenal hypoplasia: new mutations and long-term follow-up in three patients
    G Binder
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, Tuebingen, Germany
    Clin Endocrinol (Oxf) 53:249-55. 2000
    Mutations of the DAX-1 gene, which encodes a newly discovered member of the nuclear hormone receptor family, were reported to cause X-linked congenital adrenal hypoplasia and hypogonadotrophic hypogonadism...
  93. ncbi Comparative localization of Dax-1 and Ad4BP/SF-1 during development of the hypothalamic-pituitary-gonadal axis suggests their closely related and distinct functions
    Y Ikeda
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Dev Dyn 220:363-76. 2001
    ..Furthermore, we noticed the presence of cells that express Dax-1 but not Ad4BP/SF-1, further indicating additional functions of Dax-1 in an Ad4BP/SF-1-independent molecular mechanism...
  94. ncbi Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
    Susan Y Park
    Division of Endocrinology and Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Development 132:2415-23. 2005
    Mutations of orphan nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans, although the pathological features are distinct...
  95. doi Alternate hypothesis on the pathogenesis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in dengue virus infection
    Sansanee Noisakran
    Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani, 12120, Thailand
    Exp Biol Med (Maywood) 233:401-8. 2008
    ..are 200,000 to 500,000 cases of potential life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), characterized by thrombocytopenia and increased vascular permeability...
  96. ncbi High sucrose diets increase blood pressure of both salt-sensitive and salt-resistant rats
    H G Preuss
    Department of Medicine, Georgetown University Medical Center, Washington, DC 20007
    Am J Hypertens 5:585-91. 1992
    ..Dahl salt-sensitive (DSS) and salt-resistant (DSR) rats were fed one of two low salt diets containing either high sugar (sucrose 51...
  97. ncbi In vivo inhibition of steroidogenic acute regulatory protein expression by dexamethasone parallels induction of the negative transcription factor DAX-1
    Chi Chuan Yu
    Department of Physiology, National Cheng Kung University College of Medicine, Tainan 70101, Taiwan, Republic of China
    Endocrine 30:313-23. 2006
    ....
  98. ncbi Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women
    R M Calvo
    Department of Endocrinology, , Madrid 28034, Spain
    J Clin Endocrinol Metab 86:1746-9. 2001
    ..In conclusion, mutations in StAR, SF-1, CYP11A, and DAX-1 are seldom found in hirsute patients and do not explain the steroidogenic abnormalities found in these women...
  99. ncbi Proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment
    Yoshio Araki
    Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    Int J Mol Med 25:203-8. 2010
    ..As an animal model, the oral administration of dextran sulfate sodium (DSS) induces colitis, which exhibits several clinical and histological features similar to UC...
  100. ncbi Results of low-dose methotrexate treatment of persistent gestational trophoblastic disease in Sheffield 1980-1987
    M S Dorreen
    Royal Hallamshire Hospital, Jessop Hospital for Women, Sheffield, England
    Acta Oncol 27:551-6. 1988
    ..October 1987, 115 evaluable patients were treated in Sheffield for persistent gestational trophoblastic disease (GTD) with a low dose methotrexate regimen (LD-MTX). Each course comprised MTX 50 mg given by i.m...
  101. ncbi Natural history of human T-lymphotropic virus 1-associated myelopathy: a 14-year follow-up study
    Stephane Olindo
    Department of Neurology, University Hospital of Fort de France, Fort de France, Martinique
    Arch Neurol 63:1560-6. 2006
    ..The progression of neurological disability in human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) remains undefined...

Research Grants81

  1. CAM Curriculum Project
    Mary Jo Kreitzer; Fiscal Year: 2004
    ..care and spirituality into the academic, research, and clinical programs of the Academic Health Center (AHC)...
  2. Vincent W Yang; Fiscal Year: 2016
    ..In addition, it was shown recenty that KLF5 is necessary for mucosal healing in the dextran sulfate sodium (DSS) mouse model of colitis...
  3. Yatrik M Shah; Fiscal Year: 2016
    ..This will be examined in a well-characterized CAC model using azoxymethane (AOM) and dextran sulfate sodium (DSS) in mice that are disrupted for HIF2a or mice that overexpress HIF2a specifically in the colon...
  4. Lori A Coburn; Fiscal Year: 2016
    ..Eotaxin-1 has been shown to be increased in dextran sulfate sodium (DSS) induced colitis by my collaborator, and we now show for the first time that eotaxin-1 is upregulated in: 1) ..
  5. Keith T Wilson; Fiscal Year: 2016
    ..is effective as a treatment for epithelial injury and inflammation induced by dextran sulfate sodium (DSS), a model that mimics UC. CAT2 expression, L-Arg uptake, and L-Arg levels are all decreased in UC tissues...
  6. A novel agent suppresses colitis and colon cancer
    Nengtai Ouyang; Fiscal Year: 2013
    ..this proposal, we will further confirm and refine the inhibitory effect of the peptide in dextran sulfate sodium (DSS)-induced acute colitis mouse model. The mechanism by which this peptide suppresses colitis will also be explored...
  7. Chemokine Decoy Receptor: a novel therapy of IBD
    Kanneganti Murthy; Fiscal Year: 2012
    ..Specific Aims: Establish the pharmacodynamic profile of mR-421 in mice utilizing 1) a dextran sulfate sodium (DSS) model and 2) a dintrobenzenesulfonic (DNBS) model of intestinal inflammation Treatment with mR-421 (3, 10, and 30 ..
  8. Treatment of Inflammatory Bowel Disease with Ceramidase Inhibitors
    Lynn W Maines; Fiscal Year: 2012
    ..2. To evaluate the therapeutic efficacies of ceramidase inhibitors in the DSS model of ulcerative colitis...
  9. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..preliminary studies that the deletion of the PGRN gene renders B6 mice more susceptible to Dextran Sulfate Sodium (DSS) induction and to developing more severe colitis...
  10. Dezheng Zhao; Fiscal Year: 2016
    ..have shown that Nur77 is highly induced in acute trisnitrobenzene sulfonic acid (TNBS) and dextran sulfate sodium (DSS) experimental colitis...
  11. The impact of Helicobacter pylori infection on inflammatory bowel disease suscept
    John Kao; Fiscal Year: 2009
    ..2. To study the impact of H. pylori-induced Tregs on mouse susceptibility to chronic dextran sulfate sodium (DSS)-colitis. 2.1. To demonstrate the presence of extragastric H. pylori-specific Tregs response induced by H...
  12. Novel Intervention for Colitis
    MICHAEL VITEK; Fiscal Year: 2007
    ..rodentium) model, an acute Dextran Sulfate Sodium (DSS) model and a chronic DSS model of colitis...
  13. The Role of a Novel Vitamin E Metabolite in Colon Cancer Prevention and Therapy
    Qing Jiang; Fiscal Year: 2012
    ..model, in which colon carcinogenesis is induced by azoxymethane (AOM) and is accelerated by dextran sulfate sodium (DSS)-caused colon inflammation...
  14. Inducible colon-specific transgenic mouse for cancer research
    James C Fleet; Fiscal Year: 2013
    ..Additional studies will be done in the presence of colonic inflammation induced by dextran sulfate sodium (DSS)...
  15. Colorectal cancer chemoprevention with phytochemical combinations
    Swati Nagar; Fiscal Year: 2013
    ..efficacy from Aim 1 will be tested in a dextran sulfate sodium + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (DSS/PhIP) colon adenocarcinoma mouse model, and aberrant crypt foci (ACF), tumor size/frequency, and ugt induction will ..
  16. Yan Cui; Fiscal Year: 2016
    ..myeloid precursors synergistically enhances chronic inflammation and tumorigenesis in the dextran sulfate sodium (DSS)-induced colon cancer, whereas targeted restoration of p53 in fibroblast or MDSC delays colon cancer development...
  17. Babak Oskouian; Fiscal Year: 2016
    ..We now show that SPL is also downregulated in tumors that develop in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice. Thus, SPL downregulation is a common feature of intestinal neoplasia...
  18. Vincent W Yang; Fiscal Year: 2014
    ..as lipopolysaccharide (LPS), pathogenic bacterial infection by Citrobacter rodentium, and dextran sodium sulfate (DSS)-induced colitis...
  19. Soluble epoxide hydrolase as a novel target of colitis-induced carcinogenesis
    Guang Yu Yang; Fiscal Year: 2012
    ..are performed: 1) Determine the role of sEH in colitis-induced carcinogenesis using sEH knockout mice in our novel DSS-induced carcinogenesis model, and a spontaneous colitis-carcinogenesis model in double-knockout (sEH and IL-10) ..
  20. Identification of Lactobacillus Secreted Factors in Regulation of Pgp
    Seema Saksena; Fiscal Year: 2013
    ..Further, a decrease in function and expression of Pgp has been shown in experimental mouse model of DSS-induced colitis...
  21. The role of ErbB-4 in inflammation-induced colon carcinogenesis
    Mark R Frey; Fiscal Year: 2011
    ..expression of ErbB-4 isoforms during tumorigenesis and determining the effect of ErbB-4 deletion on AOM/DSS tumorigenesis in vivo;(2) Define the role(s) of full-length and intracellular domain ErbB-4 isoforms in intestinal ..
  22. GROWTH FACTORS AND INFLAMMATORY BOWEL DISEASE
    Pauline K Lund; Fiscal Year: 2013
    ..Aim 1 will define the cellular and molecular mechanisms and gene targets associated with enhanced AOM/DSS-induced tumorigenesis in mice with IEC-SOCS3 deletion...
  23. Eugene Chang; Fiscal Year: 2016
    ..intensifying the inflammatory response, (3) gene-targeted deletion of Hsp70 transforms the otherwise, self-limited, DSS-induced colitis to a chronic, IBD-like colitis, and (4) after AOM/DSS challenge, multi-focal, flat dysplasia-to-..
  24. Claire Larmonier; Fiscal Year: 2014
    ..dispensable in T-cells, while Parp1-/- mice are protected from colitis resulting from epithelial damage induced by DSS. These data collectively suggests that the pathogenic role of Parp1 in colitis is restricted to either colonic ..
  25. Prema Robinson; Fiscal Year: 2014
    ..In preliminary studies, we demonstrated that C188-9 almost completely prevents dextran sodium sulphate (DSS)-induced colitis in mice...
  26. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..inflammation and oxidative stresses, Nrf2-deficient mice were found to be more susceptible to inflammatory agent DSS-induced colitis...
  27. Hamed Laroui; Fiscal Year: 2016
    ..We have demonstrated that DSS-induced colitis is aggravated in villin-CD98 transgenic mice (in which CD98 is expressed in colonocytes) than wild-..
  28. Amar B Singh; Fiscal Year: 2015
    ..3) Cl-2Tg mice are significantly protected from experimental-colitis [induced using dextran sodium sulfate (DSS, 4% w/v in drinking water)] compared to WT littermates (p<0.001)...
  29. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..acid (supplemented to colonic crypt cells) into 13-S-HODE and PGE2 in mice treated with dextran sodium sulfate (DSS) to induce colitis. Aim 2: To determine whether 15-LOX-1 suppresses chronic colitis...
  30. Hans Christian Reinecker; Fiscal Year: 2016
    ..that overexpression of IL-22BP impaired the recovery from acute colitis induced by dextran sodium sulfate (DSS). However, only little information is currently available on the IL-22BP in any research fields, including IBD...
  31. Chemoprevention of Colitis-Associated Neoplasia by 5-ASA
    Margie L Clapper; Fiscal Year: 2012
    ..acid (5-ASA), the first-line therapy for the treatment of human colitis, to inhibit the multiplicity of AOM/DSS-induced colitis-associated dysplasias in mice when given prior to the induction of colitis...
  32. PURINERGIC REGULATION OF ENTERIC NEURAL REFLEXES
    FEDIAS LEONTIOU CHRISTOFI; Fiscal Year: 2011
    ..Hypothesis 2.2 is tested that A3Rs confer protection in genomic models of colitis. It is tested using DSS in C57BL/6 A3 KO or FVB/N profilin transctenic mice with 8-fold up-regulation of A3Rs...
  33. Mark R Frey; Fiscal Year: 2016
    ..colonocytes from cytokine-induced apoptosis both in vitro and in vivo, and reduces the severity of acute murine DSS colitis...
  34. Darren D Browning; Fiscal Year: 2016
    ..activation by PDE-5 inhibitors on barrier function, inflammation, and tumorigenesis using Prkg2-/- mice and both DSS/AOM and ApcMin/+ mouse cancer models...
  35. Dietary Prevention of Cancer
    Shrikant Anant; Fiscal Year: 2013
    ..efficacy of a combination of curcumin and marmelin in preventing intestinal and colonic tumorigenesis in the AOM/DSS-induced mouse colon cancer model...
  36. Sergei I Grivennikov; Fiscal Year: 2015
    ..For a long time our lab has used a azoxymethane+DSS induced CAC mouse model to mimic CAC development in humans...
  37. The Role of Interleukin 23 In Colitis Associated Cancer
    Sergei I Grivennikov; Fiscal Year: 2012
    ..For a long time our lab has used a azoxymethane+DSS induced CAC mouse model to mimic CAC development in humans...
  38. Protease Pathways in the Gastrointestinal Tract
    Toni M Antalis; Fiscal Year: 2010
    ..segments, and dramatically enhances susceptibility to experimental colitis induced by dextran sodium sulfate (DSS)...
  39. ROSE LINDA SZABADY; Fiscal Year: 2015
    ..and will broaden the applicability of these findings by investigating the regulation of HXA3 activity by AMEND in DSS colitis and T cell transfer, two established mouse models of non-infectious colitis...
  40. The role of the mu-Opioid Receptor in Inflammatory Bowel Disease Pathology and Th
    Jason R Goldsmith; Fiscal Year: 2013
    ..Preliminary data shows that MOR agonist ameliorates DSS colitis. However, the mechanism of action of DSS- mediated protection remains unknown...
  41. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..Interestingly, SCD-1 deficiency exacerbates intestinal inflammation in an acute model of Dextran Sodium Sulfate (DSS) and C. rodentium induced colitis and SCD-1 overexpression significantly attenuated such colitis...
  42. Anisa Shaker; Fiscal Year: 2016
    ..We will extend these observations to the dextran sodium sulfate (DSS) colitis and azoxymethane (AOM)/DSS CAC models...
  43. Kara Gross Margolis; Fiscal Year: 2016
    ..expression of genes encoding proinflammatory molecules, levels of neutrophil elastase and p50 NF B) of TNBS- and DSS-induced colitis are higher in NSE- noggin and lower in Hand2+/- mice than in their wild-type (WT) littermates...
  44. Development of the orally delivered, non-absorbable ACE inhibitor enalaprilat for
    ELKE LIPKA; Fiscal Year: 2010
    ..We have recently demonstrated the ability to palliate the progression of colitis in a mouse dextran sodium sulfate (DSS) model through blockage of signaling via the inhibition of the angiotensin-converting enzyme (ACE) in the renin-..
  45. NICHOLAS DAVIDSON; Fiscal Year: 2016
    ..intestinal lipotoxicity and that both Mttp-IKO and Apobec-1-/- mice demonstrate increased mortality with DSS colitis which is further exacerbated in the double knockout background...
  46. Yoon Kwang Lee; Fiscal Year: 2016
    ..Small heterodimer partner (SHP, NR0B2) belongs to the nuclear hormone receptor superfamily. Earlier molecular studies suggested that SHP plays a role in glucose and lipid metabolism...
  47. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..enterocolitica and Salmonella) engineered to express only YopP will be applied to modulate inflammation in DSS-induced colitis in neonates. In addition, cell types critical for Y...
  48. Oral anti-TNF antibody for inflammatory bowel disease
    Daniel E Tracey; Fiscal Year: 2013
    ..antibody specific for murine TNF) significantly reduced the severity of colitis in the well-established TNBS and DSS mouse models of IBD while blood levels remained low...
  49. SIMON PATRICK HOGAN; Fiscal Year: 2015
    ..We will employ S100A9-/-, RAGE-/-, CCR2-/-, CCR2-/-/Il10-/- mice;use DSS- and NSAID-induced Il10-/- models of colitis;generate bone marrow-derived M[unreadable]-specific chimeric mice and ..
  50. Sandra J Gendler; Fiscal Year: 2014
    ..the periphery, (3) To determine the effect of a lack of Muc1 in myeloid development during dextran sodium sulfate (DSS)-induced colitis and colitis associated cancer (CAC) by using chimeric mice that lack or have Muc1 in the ..
  51. Epithelial-mesenchymal interactions in gut morphogenesis
    Deborah C Rubin; Fiscal Year: 2010
    ..3. Determine mechanisms by which epimorphin deletion ameliorates injury induced by DSS, and whether this enhances carcinogenesis associated with DSS-induced injury/inflammation...
  52. Bobak Parang; Fiscal Year: 2015
    ..induce intestinal injury in BVES-/- mice using two complementary animals models of colitis: dextran sodium sulfate (DSS) and Citrobacter rodentium infection...
  53. THERESA TORRES PIZARRO; Fiscal Year: 2014
    ..We will first study the effect of intestinal injury induced by DSS in mice deficient in TL1A and DR3...
  54. David M Underhill; Fiscal Year: 2015
    ..We have observed that mice lacking Dectin-1 are more susceptible to acute colitis induced by DSS than wild type mice and that this enhanced sensitivity is due to intestinal fungi...
  55. Arianne L Theiss; Fiscal Year: 2014
    ..inflammatory bowel disease (IBD) and experimental colitis, and 4) prohibitin transgenic mice are protected from DSS- and Salmonella typhimurium-induced colitis and oxidative stress...
  56. Control of colonic motility in health and disease.
    Sushil K Sarna; Fiscal Year: 2012
    ..induced colonic inflammation that mimics the classic features of Crohn's disease, and dextran sodium sulfate (DSS) - induced colonic inflammation that mimics those of ulcerative colitis...
  57. PROSTAGLANDINS IN EPITHELIAL INJURY
    William F Stenson; Fiscal Year: 2013
    ..Hyaluronic acid is produced in response to gastrointestinal injury in the DSS colitis model and in radiation injury in the small intestine. 2...
  58. Terrence A Barrett; Fiscal Year: 2015
    ..Data already produced in VilCre/pik3r1fl/fl mice given DSS colitis suggest that PI3K-mediated B-catenin activation plays a major role in wound healing...
  59. The Impact of TLR on Intestinal Tumorigenesis
    Eyal Raz; Fiscal Year: 2010
    ..Thus, in SA-2, we will treat Apc, and Apc mutants (see above) with the colitis-inducing chemical, DSS, followed by oral administration of UO126 or Sorafenib (a RAS-RAF inhibitor)...
  60. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Our initial studies show that mice homozygous for this mutation exhibit greater acute inflammation in the DSS-induced model of colitis, and their macrophages are more responsive to MDP, displaying enhanced activation of NFKB ..
  61. GC-C agonists for colitis-induced CRC
    Kunwar Shailubhai; Fiscal Year: 2009
    ..Recently, we also demonstrated that treatment with SP304 ameliorated GI inflammation in DSS- and TNBS- induced colitis models...
  62. PEDRO JI SALAS; Fiscal Year: 2015
    ..a profound downregulation of atypical PKC in intestinal epithelial cells under TNF[unreadable] stimulation, in the DSS model of murine colitis, and in Inflammatory Bowel Disease patients...
  63. Development of orally delivered, non-absorbable AT1 receptor antagonists for infl
    John Hilfinger; Fiscal Year: 2009
    ..We have recently demonstrated the ability to palliate the progression of colitis in a mouse dextran sodium sulfate (DSS) model through blockage of signaling via the type 1a (AT1a) receptor of the renin-angiotensin system...
  64. Barbara J Meyer; Fiscal Year: 2016
    ..One XSE is a nuclear hormone receptor (NHR) called SEX-1, a homolog of the retinoic acid receptor (RAR) gene family that participates in ..
  65. Peter B Dervan; Fiscal Year: 2014
    ..Glucocorticoid receptor (GR) is a nuclear hormone receptor that modulates the inflammatory response through a variety of mechanisms, including DNA binding of ..
  66. Early Events in Colitis-Associated Colorectal Cancer
    Wen Chi Chang; Fiscal Year: 2003
    ..The dextran sulfate sodium (DSS) model of induced colitis provides a unique opportunity to evaluate the spectrum of histological changes that lead ..
  67. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..proteins that have roles in metabolism, including insulin II (Ins2), resistin, and adiponectin, and the nuclear hormone receptor PPAR...
  68. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
    ..Dextran sulfate sodium (DSS)-induced colitis is an animal model for studying both inflammation and colitis-associated neoplasia...
  69. A Novel Cytoprotective Peptide for GI Epithelial Cell
    FREDERICK TOBACK; Fiscal Year: 2005
    ..epithelial cell (Caco-2/bbe) cultures subjected to injury by an oxidant, indomethacin, or dextran sulfate sodium (DSS) used to induce colitis in mice, Studies in cell culture indicate that this AMP peptide activates p38 MAP kinase, ..
  70. Development of a High Throughput Screening Assay for RORgamma
    THOMAS BURRIS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The human nuclear hormone receptor (NHR) superfamily consists of 48 members approximately half of which have no identified ligands and are termed "orphan receptors"...
  71. Thrombospondin in ulceractive colitis and carcinogenesis
    Linda S Gutierrez; Fiscal Year: 2010
    ..Recently we reported that TSP1 deficient (TSP1-/-) mice show aggravation of colitis using the DSS model. TSP1-/- colons also displayed enhanced expression of markers of carcinogenesis...
  72. Role of Leptin in murine modeles of IBD
    Giamila Fantuzzi; Fiscal Year: 2007
    ..ob/ob) and leptin receptor-deficient (db/db) mice are resistant to colitis induced by chronic administration of DSS or TNBS. The current application will attempt to identify the cell populations responsible for the observed effects...
  73. GENETICS OF DELAYED PUBERTY
    LAWRENCE LAYMAN; Fiscal Year: 2001
    ..Potentially, contraceptive technologies could be developed based upon the understanding of the function of newly identified genes. ..
  74. Investigation of the Molecular Determinants of DAX-1 Mediated X-Linked Adrenal Hy
    Christina Tzagarakis Foster; Fiscal Year: 2009
    ..DAX-1 has been shown to interact with other members of the nuclear hormone receptor family such as estrogen receptor (ER), androgen receptor (AR), thyroid hormone receptor (TR), and ..
  75. Soft X-ray Laser for Imaging DNA in Vivo
    MARVIN NIIMURA; Fiscal Year: 2009
    ..pumping scheme that would require a building-size terawatt (TW) laser system, nor on the high harmonic generation (HHG) scheme where efficiency is low due to the nonlinear (or multi-photon absorption) process...
  76. Community-Academic Partnership: Building an Infrastructure to Improve Health for
    Beth A Marks; Fiscal Year: 2010
    ..by applicant): This project seeks to create an infrastructure for a collaborative community-academic health center (AHC) partnership to enhance health status and optimize full community participation of people with developmental ..
  77. NUCLEAR HORMONE ACTION--ROLE OF UBIQUITIN PATHWAYS
    Zafar Nawaz; Fiscal Year: 2003
    ..These observations suggest a possible regulatory role for the ubiquitin and NEDD8 pathways in nuclear hormone receptor-mediated gene activation...
  78. Echium Oil Modulates Macrophage Inflammation by Promoting Alternative Activation
    AMANDA WIBLEY; Fiscal Year: 2010
    ..The nuclear hormone receptor PPAR gamma acts as a lipid-sensor and likely directs this modulation of macrophage activation phenotypes ..
  79. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..The objective of this project is to provide infrastructure services to the community and academic health centers (AHC) to overcome collaboration barriers to form community-academic partnerships to conduct health science research...
  80. Development of a Hand Exoskeleton for Rehabilitation Following Stroke
    DEREK KAMPER; Fiscal Year: 2009
    ..Thus, we propose to develop an actuated exoskeleton (AHX) for the index finger and thumb with a novel intelligent controller to coordinate the activities of the different ..
  81. Impact of decision support and accountability tools on adoption of evidence
    Ramin Khorasani; Fiscal Year: 2010
    ..This study will implement and assess impact of a real-time clinical decision support system (DSS) embedded in computerized physician order entry (CPOE) as a vehicle for increasing the pace of dissemination and ..