cystatin C

Summary

Gene Symbol: cystatin C
Description: cystatin C
Alias: ARMD11, HEL-S-2, cystatin-C, bA218C14.4 (cystatin C), cystatin 3, epididymis secretory protein Li 2, gamma-trace, neuroendocrine basic polypeptide, post-gamma-globulin
Species: human

Top Publications

  1. ncbi Expression of Cystatin C in the rat endometrium during the peri-implantation period
    Claire E Quinn
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ont, Canada N6A 5C1
    Biochem Biophys Res Commun 349:236-44. 2006
  2. doi Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes
    V Rigalleau
    Nutrition Diabétologie, Hopital Haut Leveque, Avenue de Magellan, 33600 Pessac, France Université de Bordeaux II Victor Segalen, 33000 Bordeaux, France
    Diabetes Metab 34:482-9. 2008
  3. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
  4. ncbi Influence of thyroid hormones and transforming growth factor-β1 on cystatin C concentrations
    N Kotajima
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Int Med Res 38:1365-73. 2010
  5. ncbi Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Mail Stop A140, Aurora, CO 80045, USA
    Diabetes 56:2774-9. 2007
  6. ncbi Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis
    M Abrahamson
    Department of Clinical Chemistry, University of Lund, University Hospital, Sweden
    Hum Genet 89:377-80. 1992
  7. pmc Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
    P Lindahl
    Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Uppsala Biomedical Center
    Biochem J 281:49-55. 1992
  8. pmc Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction
    J Ghiso
    Department of Pathology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 87:1288-91. 1990
  9. ncbi Mutation in cystatin C gene causes hereditary brain haemorrhage
    A Palsdottir
    National Hospital, University of Iceland, Reykjavik
    Lancet 2:603-4. 1988
  10. ncbi Human cystatin, a new protein inhibitor of cysteine proteinases
    J Brzin
    Biochem Biophys Res Commun 118:103-9. 1984

Detail Information

Publications167 found, 100 shown here

  1. ncbi Expression of Cystatin C in the rat endometrium during the peri-implantation period
    Claire E Quinn
    Department of Physiology and Pharmacology, The University of Western Ontario, London, Ont, Canada N6A 5C1
    Biochem Biophys Res Commun 349:236-44. 2006
    ..An interesting pattern for Cystatin C (Cst3) expression was discovered with a peak in abundance just prior to embryo implantation (day 4 of pregnancy) ..
  2. doi Cystatin C improves the diagnosis and stratification of chronic kidney disease, and the estimation of glomerular filtration rate in diabetes
    V Rigalleau
    Nutrition Diabétologie, Hopital Haut Leveque, Avenue de Magellan, 33600 Pessac, France Université de Bordeaux II Victor Segalen, 33000 Bordeaux, France
    Diabetes Metab 34:482-9. 2008
    ..Estimation of glomerular filtration rate (GFR) is recommended to diagnose and stratify chronic kidney disease (CKD). Can cystatin-C (cysC) assay improve the results in diabetic patients?..
  3. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..Plasma cystatin C is more accurate than creatinine for identifying stage 3 kidney disease in T2DM...
  4. ncbi Influence of thyroid hormones and transforming growth factor-β1 on cystatin C concentrations
    N Kotajima
    Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Int Med Res 38:1365-73. 2010
    Serum cystatin C concentrations are reported to increase in the hyperthyroid state...
  5. ncbi Serum cystatin C predicts progression of subclinical coronary atherosclerosis in individuals with type 1 diabetes
    David M Maahs
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Mail Stop A140, Aurora, CO 80045, USA
    Diabetes 56:2774-9. 2007
    Renal function is an important determinant of coronary atherosclerosis, and serum cystatin C is a novel accurate measure of glomerular filtration rate (GFR) and a predictor of cardiovascular events and mortality...
  6. ncbi Hereditary cystatin C amyloid angiopathy: identification of the disease-causing mutation and specific diagnosis by polymerase chain reaction based analysis
    M Abrahamson
    Department of Clinical Chemistry, University of Lund, University Hospital, Sweden
    Hum Genet 89:377-80. 1992
    Hereditary cystatin C amyloid angiopathy (HCCAA) is a dominantly inherited disease characterized by amyloidosis, dementia and fatal cerebral hemorrhage of young adults. A method for rapid and simple diagnosis of HCCAA is described...
  7. pmc Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin
    P Lindahl
    Department of Veterinary Medical Chemistry, Swedish University of Agricultural Sciences, Uppsala Biomedical Center
    Biochem J 281:49-55. 1992
    The interaction between recombinant human cystatin C and the cysteine proteinases papain and actinidin was studied by spectroscopic, kinetic and equilibrium methods. The absorption, near-u.v.c.d...
  8. pmc Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction
    J Ghiso
    Department of Pathology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 87:1288-91. 1990
    ..that the antisense peptide Ser-Tyr-Asp-Leu complementary to the segment Gln-Ile-Val-Ala-Gly (residues 55-59) in cystatin C (an inhibitor of cysteine proteases) is located at positions 611-614 of the beta chain of human C4, the fourth ..
  9. ncbi Mutation in cystatin C gene causes hereditary brain haemorrhage
    A Palsdottir
    National Hospital, University of Iceland, Reykjavik
    Lancet 2:603-4. 1988
    Hereditary cystatin C amyloid angiopathy (HCCAA) is an autosomal dominant disorder in which a cysteine proteinase inhibitor, cystatin C, is deposited as amyloid fibrils in the cerebral arteries of patients and leads to massive brain ..
  10. ncbi Human cystatin, a new protein inhibitor of cysteine proteinases
    J Brzin
    Biochem Biophys Res Commun 118:103-9. 1984
    ..Very probably human cystatin is identical with human gamma-trace, a microprotein of known sequence but hitherto unknown function...
  11. pmc Cystatin C deficiency in human atherosclerosis and aortic aneurysms
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1191-7. 1999
    ..We show here that, whereas cystatin C is normally expressed in vascular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely ..
  12. ncbi A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease
    F C Crawford
    Roskamp Institute University of South Florida, Tampa, FL 33613, USA
    Neurology 55:763-8. 2000
    To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD.
  13. ncbi Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping
    R Janowski
    Department of Crystallography, Faculty of Chemistry, A Mickiewicz University, Grunwaldzka 6, 60 780 Poznan, Poland
    Nat Struct Biol 8:316-20. 2001
    The crystal structure of human cystatin C, a protein with amyloidogenic properties and a potent inhibitor of cysteine proteases, reveals how the protein refolds to produce very tight two-fold symmetric dimers while retaining the secondary ..
  14. ncbi Alzheimer disease-associated cystatin C variant undergoes impaired secretion
    Luisa Benussi
    Neurobiology Lab, IRCCS Centro San Giovanni di Dio, Italy
    Neurobiol Dis 13:15-21. 2003
    CST3 is the coding gene for cystatin C (CysC). CST3 B/B homozygosity is associated with an increased risk of developing Alzheimer disease...
  15. ncbi Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease
    Per Eriksson
    Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, S 171 76 Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 24:551-7. 2004
    ..The potential significance of imbalance in expression between cathepsins and their inhibitor cystatin C in cardiovascular disease has been highlighted by the demonstration of cystatin C deficiency in human ..
  16. ncbi Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
    Eric L Knight
    Channing Laboratory, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1416-21. 2004
    ..Serum cystatin C has been proposed as a potentially superior marker than serum creatinine, because serum cystatin C level is ..
  17. ncbi Binding of cystatin C to Alzheimer's amyloid beta inhibits in vitro amyloid fibril formation
    Magdalena Sastre
    Departments of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA
    Neurobiol Aging 25:1033-43. 2004
    The colocalization of cystatin C, an inhibitor of cysteine proteases, with amyloid beta (Abeta) in parenchymal and vascular amyloid deposits in brains of Alzheimer's disease (AD) patients may reflect cystatin C involvement in ..
  18. ncbi Biochemistry and clinical role of human cystatin C
    Michele Mussap
    Department of Laboratory Medicine, University Hospital of Padua, Padua, Italy
    Crit Rev Clin Lab Sci 41:467-550. 2004
    Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily...
  19. ncbi 3D domain-swapped human cystatin C with amyloidlike intermolecular beta-sheets
    Robert Janowski
    Department of Crystallography, Faculty of Chemistry, A Mickiewicz University, Poznan, Poland
    Proteins 61:570-8. 2005
    Oligomerization of human cystatin C (HCC) leads to amyloid deposits in brain arteries, and this process is greatly accelerated with a naturally occurring L68Q variant...
  20. ncbi Identification of potential CSF biomarkers in ALS
    G M Pasinetti
    Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neurology 66:1218-22. 2006
    ..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis...
  21. ncbi The role of cystatin C in cerebral amyloid angiopathy and stroke: cell biology and animal models
    Efrat Levy
    Department of Psychiatry, New York University School of Medicine, and Nathan Kline Institute, Orangeburg 10962, USA
    Brain Pathol 16:60-70. 2006
    A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages ..
  22. ncbi A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes
    Grzegorz Placha
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 55:3358-65. 2006
    ..GFR was estimated from serum concentrations of cystatin C and creatinine in 406 diabetic and 428 nondiabetic relatives...
  23. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..67 for protective alleles). Our database provides a powerful tool for deciphering the genetics of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases...
  24. pmc Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study
    David Singh
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    Nephrol Dial Transplant 22:1087-92. 2007
    b>Cystatin C is a marker of kidney function that may also be associated with inflammation...
  25. ncbi Genotype and plasma concentration of cystatin C in patients with late-onset Alzheimer disease
    Liang Jen Chuo
    Department of Psychiatry, Taichung Veterans General Hospital, Taichung, and Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
    Dement Geriatr Cogn Disord 23:251-7. 2007
    A polymorphism locating at position 73 of cystatin C (CST3) exon 1 was suggested to be associated with Alzheimer disease (AD), but with contradictory results...
  26. ncbi Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Pediatr Nephrol 22:1007-13. 2007
    Serum concentration of cystatin C, a marker of glomerular filtration, has been associated with incident cardiovascular disease (CVD), although the pathophysiology underlying this association remains unclear...
  27. ncbi Fibrillogenic oligomers of human cystatin C are formed by propagated domain swapping
    Maria Wahlbom
    Department of Clinical Chemistry, Lund University Hospital, S 221 85 Lund, Sweden
    J Biol Chem 282:18318-26. 2007
    b>Cystatin C and the prion protein have been shown to form dimers via three-dimensional domain swapping, and this process has also been hypothesized to be involved in amyloidogenesis...
  28. ncbi Increased urinary cystatin C reflects structural and functional renal tubular impairment independent of glomerular filtration rate
    Stefan Herget-Rosenthal
    Department of Nephrology, University Hospital, Essen, University Duisburg Essen, Germany
    Clin Biochem 40:946-51. 2007
    The ratio of the urinary mass concentrations of cystatin C and creatinine (UcysC/Ucrea)>/=11.3 mg/mmol has recently been proposed as an accurate marker for the detection of GFR</=60 mL/min/1.73 m(2).
  29. ncbi Cystatin C binds serum amyloid A, downregulating its cytokine-generating properties
    Maria Bokarewa
    Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Goteborg, Sweden
    J Rheumatol 34:1293-301. 2007
    To assess the interaction between cystatin C (CysC) and serum amyloid A protein (SAA).
  30. ncbi Relations between markers of renal function, coronary risk factors and the occurrence and severity of coronary artery disease
    Jun Wang
    Department of Cardiovascular Medicine, University of New South Wales, Prince of Wales Hospital, Sydney, Australia
    Atherosclerosis 197:853-9. 2008
    ..To explore this we assessed relations between measures of mild impairment of renal function and coronary artery disease (CAD) together with other risk factors...
  31. ncbi Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models
    Weiqian Mi
    Nathan S Kline Institute, Orangeburg, New York 10962, USA
    Nat Genet 39:1440-2. 2007
    Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-beta peptide and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice...
  32. ncbi Cystatin C modulates cerebral beta-amyloidosis
    Stephan A Kaeser
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Otfried Muller Strasse 27, D 72076 Tubingen, Germany
    Nat Genet 39:1437-9. 2007
    The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease...
  33. doi Cystatin C--a marker of peripheral atherosclerotic disease?
    J Arpegård
    Department of Medicine, Division of Emergency Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
    Atherosclerosis 199:397-401. 2008
    It has been suggested that Cystatin C, besides its function as a marker of glomerular filtration, could be an independent marker of cardiovascular disease. However, studies on this topic are few and results have been indecisive...
  34. doi Serial measurements of cystatin C are more accurate than creatinine-based methods in detecting declining renal function in type 1 diabetes
    Erosha Premaratne
    Endocrine Centre, Austin Health, University of Melbourne, Melbourne, Australia
    Diabetes Care 31:971-3. 2008
    b>Cystatin C-and creatinine-based methods were compared with (99m)-technetium-diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) plasma clearance (isotopic glomerular filtration rate [iGFR]) for detecting declining renal function.
  35. pmc Serum cystatin C and the risk of Alzheimer disease in elderly men
    J Sundelof
    Uppsala University, Department of Public Health Geriatrics, Uppsala Science Park, Uppsala, Sweden
    Neurology 71:1072-9. 2008
    Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD).
  36. pmc Factors other than glomerular filtration rate affect serum cystatin C levels
    Lesley A Stevens
    Division of Nephrology, Clinical Care Research, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 75:652-60. 2009
    b>Cystatin C is an endogenous glomerular filtration marker hence its serum level is affected by the glomerular filtration rate (GFR)...
  37. doi Comparisons of cystatin C with creatinine for evaluation of renal function in chronic kidney disease
    Masatomo Yashiro
    Division of Nephrology, Kyoto City Hospital, Nakagyo ku, Kyoto, Japan
    Clin Exp Nephrol 13:598-604. 2009
    Because of the limitations of creatinine (Cr) as a marker for the glomerular filtration rate (GFR), cystatin C (CysC) has been proposed as an alternative substance. The aim here was to clarify the characteristics of CysC compared with Cr.
  38. doi Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients
    Seung Hwan Lee
    Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, St Vincent s Hospital, Suwon 442 723, Korea
    Metabolism 59:241-6. 2010
    Recent studies suggest that serum cystatin C level is not only a sensitive marker for renal dysfunction but also a predictive marker for cardiovascular disease (CVD). However, the mechanism of this connection is not fully understood...
  39. pmc Serum cystatin C is a potential endogenous marker for the estimation of renal function in male gout patients with renal impairment
    Jung Yoon Choe
    Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea
    J Korean Med Sci 25:42-8. 2010
    ..We investigated the diagnostic efficacy of serum cystatin C compared to that of serum creatinine levels and identified the relating factors associated with changes in serum ..
  40. doi The CST3 BB genotype and low cystatin C cerebrospinal fluid levels are associated with dementia in Lewy body disease
    Walter Maetzler
    Department of Neurodegeneration, University of Tuebingen, Germany
    J Alzheimers Dis 19:937-42. 2010
    ..b>Cystatin C (CysC) is a carrier of soluble Abeta (42) in the cerebrospinal fluid (CSF) and reduces Abeta plaque formation...
  41. doi Crystal structure of human cystatin C stabilized against amyloid formation
    Robert Kolodziejczyk
    Faculty of Chemistry, Department of Crystallography, A Mickiewicz University, Poznan, Poland
    FEBS J 277:1726-37. 2010
    Human cystatin C (HCC) is a family 2 cystatin inhibitor of papain-like (C1) and legumain-related (C13) cysteine proteases...
  42. doi Mild renal dysfunction as a non-traditional cardiovascular risk factor?-Association of cystatin C-based glomerular filtration rate with flow-mediated vasodilation
    Thorsten Reffelmann
    Klinik und Poliklinik für Innere Medizin B, Universitätsklinikum der Ernst Moritz Arndt Universität Greifswald, Friedrich Löffler Str 23 a, 17487 Greifswald, Germany
    Atherosclerosis 211:660-6. 2010
    ..The purpose of this study was to evaluate whether early stages of renal dysfunction are associated with flow-mediated vasodilatation, as an early marker of the atherosclerotic disease process...
  43. doi Cystatin C, a novel urinary biomarker for sensitive detection of acute kidney injury during haemorrhagic fever with renal syndrome
    Ying Ma
    Department of Immunology, The Fourth Military Medical University, Xi an, China
    Biomarkers 15:410-7. 2010
    To explore the value of cystatin C for evaluating acute kidney injury (AKI) in haemorrhagic fever with renal syndrome (HFRS), the concentrations of cystatin C in serum and urine samples from HFRS patients were determined...
  44. doi Association between cystatin C and inflammation in patients with essential hypertension
    Takafumi Okura
    Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Toon, Ehime 791 0295, Japan
    Clin Exp Nephrol 14:584-8. 2010
    Serum cystatin C is not only a marker of renal function but also acts as an independent risk factor for cardiovascular damage, heart failure, and death...
  45. doi Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3
    Yukiko Yamamoto-Watanabe
    Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Brain Res 1361:140-5. 2010
    b>Cystatin C (CC) is a cysteine protease inhibitor abundantly expressed in the central nervous system...
  46. doi Plasma cystatin C and risk of developing Alzheimer's disease in subjects with mild cognitive impairment
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 22:985-91. 2010
    ..Experimental and clinical data have suggested that cystatin C (CysC) is protective against the development of AD...
  47. doi Association of cystatin-C with metabolic syndrome in normal glucose-tolerant subjects (CURES-97)
    Jatagopi Surendar
    Madras Diabetes Research Foundation and Dr Mohan s Diabetes Specialities Centre, WHO Collaborating Centre for Non communicable Diseases Prevention and Control, International Diabetes Federation Centre of Education, 4 Conran Smith Road, Gopalapuram, Chennai, India
    Diabetes Technol Ther 12:907-12. 2010
    ..This study looked at the association of cystatin-C (cys-C) with severity of metabolic syndrome in Asian Indians...
  48. doi Cathepsins (S and B) and their inhibitor Cystatin C in immune cells: modulation by interferon-β and role played in cell migration
    Elsebeth Staun-Ram
    Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    J Neuroimmunol 232:200-6. 2011
    We investigated the modulation of Cathepsin S, Cathepsin B and Cystatin C expression in immune cells by interferon (IFN)-β, and their role in cell migration. Cathepsin levels were increased in monocytic and T line cells upon activation...
  49. pmc Cystatin C, a marker for successful aging and glomerular filtration rate, is not influenced by inflammation
    Anders Grubb
    Department of Clinical Chemistry, Lund University Hospital, Lund, Sweden
    Scand J Clin Lab Invest 71:145-9. 2011
    The plasma level of cystatin C is a better marker than plasma creatinine for successful aging...
  50. pmc Cystatin C as an early biomarker of nephropathy in patients with type 2 diabetes
    Yun Kyung Jeon
    Department of Internal Medicine, Pusan National University Hospital, Busan, Korea
    J Korean Med Sci 26:258-63. 2011
    This study was done to evaluate clinical usefulness of cystatin C levels of serum and urine in predicting renal impairment in normoalbuminuric patients with type 2 diabetes and to evaluate the association between albuminuria and serum/..
  51. pmc Higher cystatin C level predicts long-term mortality in patients with peripheral arterial disease
    Grazina Urbonaviciene
    Vascular Research Unit, Department of Vascular Surgery, Viborg Hospital, Heibergs Alle 4, DK 8800 Viborg, Denmark
    Atherosclerosis 216:440-5. 2011
    b>Cystatin C and cathepsins could play a role in different processes and stages of the atherosclerotic disease...
  52. doi Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance
    Masaru Horio
    Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Clin Exp Nephrol 15:868-76. 2011
    Serum cystatin C was recently proposed as an alternative marker of glomerular filtration rate (GFR), with a suggested better performance than creatinine. However, detailed studies are limited...
  53. pmc Update on cystatin C: incorporation into clinical practice
    Michael G Shlipak
    San Francisco VA Medical Center, San Francisco, CA 94121, USA
    Am J Kidney Dis 62:595-603. 2013
    ..Emerging evidence has shown that cystatin C may improve classification of glomerular filtration rate for defining chronic kidney disease in certain clinical ..
  54. pmc Estimation of glomerular filtration rate from serum creatinine and cystatin C in octogenarians and nonagenarians
    Marcelo B Lopes
    Nephrology, School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil
    BMC Nephrol 14:265. 2013
    ..of the Modification of Diet in Renal Disease (MDRD), the Chronic Kidney Disease-Epidemiology Collaboration (CKD-Epi) and the Berlin Initiative Study (BIS) equations based on creatinine and/or cystatin C in octogenarians and nonagenarians.
  55. pmc Cystatin C is a biomarker for predicting acute kidney injury in patients with acute-on-chronic liver failure
    Zhi Hong Wan
    Zhi Hong Wan, Jian Jun Wang, Shao Li You, Hong Ling Liu, Bing Zhu, Hong Zang, Chen Li, Jing Chen, Shao Jie Xin, Liver Failure Treatment and Research Center, Beijing 302 Hospital, Beijing 100039, China
    World J Gastroenterol 19:9432-8. 2013
    To investigate serum cystatin C level as an early biomarker for predicting acute kidney injury (AKI) in patients with acute-on-chronic liver failure (ACLF).
  56. pmc Structure and expression of the human cystatin C gene
    M Abrahamson
    Department of Clinical Chemistry, University Hospital, Lund, Sweden
    Biochem J 268:287-94. 1990
    The structural organization of the gene for the human cysteine-proteinase inhibitor cystatin C was studied...
  57. ncbi Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells
    Jonathan P Sokol
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cancer Res 2:183-95. 2004
    b>Cystatin C (CystC) is a secreted cysteine protease inhibitor that regulates bone resorption, neutrophil chemotaxis, and tissue inflammation, as well as resistance to bacterial and viral infections...
  58. ncbi Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland
    D P Dickinson
    Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, Georgia 30912 1124, USA
    DNA Cell Biol 21:47-65. 2002
    ..The CST3 gene, encoding cystatin C, was expressed at modest levels in all tissues examined...
  59. doi Characterization of Hlcyst-3 as a member of cystatins from the tick Haemaphysalis longicornis
    Jinlin Zhou
    Department of Frontier Veterinary Medicine, Kagoshima University, Korimoto, Japan
    Exp Appl Acarol 51:327-33. 2010
    ..The inhibitory activity of the recombinant protein against papain and cathepsin L was identified by fluorogenic substrate analysis. Real-time PCR revealed that Hlcyst-3 was mostly expressed in the tick midgut...
  60. ncbi Molecular genetics of Alzheimer's disease and aging
    Ramon Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, Bergondo, La Coruna, Spain
    Methods Find Exp Clin Pharmacol 27:1-573. 2005
    ..Furthermore, the pharmacogenomics of Alzheimer's disease may contribute in the future to optimize drug development and therapeutics, increasing efficacy and safety, and reducing side-effects and unnecessary costs...
  61. ncbi Pharmacogenomics in Alzheimer's disease
    Ramon Cacabelos
    EuroEspes Biomedical Research Center, Institute for CNS Disorders, 15166 Bergondo, La Coruna, Spain
    Mini Rev Med Chem 2:59-84. 2002
    ..Furthermore, the pharmacogenomics of AD may contribute in the future to optimise drug development and therapeutics, increasing efficacy and safety, and reducing side-effects and unnecessary costs...
  62. ncbi Pharmacogenomics for the treatment of dementia
    Ramon Cacabelos
    From the EuroEspes Biomedical Research Center, Institute for CNS Disorders, Bergondo, La Coruna, Spain
    Ann Med 34:357-79. 2002
    ..The pharmacogenomics of AD may contribute in the future to optimise drug development and therapeutics, increasing efficacy and safety, and reducing side-effects and unnecessary costs...
  63. ncbi Fetal-maternal interactions during the establishment of pregnancy in ruminants
    T E Spencer
    Center for Animal Biotechnology and Genomics, Departments of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Soc Reprod Fertil Suppl 64:379-96. 2007
    ..wingless-type MMTV integration site family member 7A) and to stimulate LGALS15, CTSL (cathepsin L), and CST3 (cystatin C), which may regulate conceptus development and implantation...
  64. ncbi Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3)
    C Huh
    Molecular and Medical Genetics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Gene 152:221-6. 1995
    b>Cystatin C (CstC) is a potent cysteine-proteinase inhibitor. The structure of the mouse CstC-encoding gene (Cst3) was examined by sequencing a 6.1-kb genomic DNA containing the entire gene, as well as 0.9 kb of 5' flanking and 1...
  65. ncbi Regulated expression and intracellular localization of cystatin F in human U937 cells
    Carl Michael Nathanson
    Department of Clinical Chemistry, Institute of Laboratory Medicine, and Department of Ophtalmology, University of Lund, University Hospital, Lund, Sweden
    Eur J Biochem 269:5502-11. 2002
    ..By contrast, U937 cells contained only 3-4% of the related inhibitor, cystatin C. Cystatin F purified from lysates of U937 cells showed three major forms carrying two, one or no carbohydrate ..
  66. ncbi DNA analysis of neonatal human remains wrapped and kept in a vinyl bag for 15 years
    Kiyoshi Minaguchi
    Department of Forensic Odontology, Tokyo Dental College, 1 2 2 Masago, Mihama ku, Chiba 261 0011, Japan
    Leg Med (Tokyo) 5:S183-6. 2003
    ....
  67. pmc Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis
    ERIK S CARLSON
    Department of Pediatrics, University of Minnesota School of Medicine, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Brain Res 1237:75-83. 2008
    ..Our results suggest a role for neonatal iron deficiency in dysregulation of genes that may set the stage for long-term neurodegenerative disease and that this may occur through a histone modification mechanism...
  68. ncbi No pathogenic mutations identified in the COL8A2 gene or four positional candidate genes in patients with posterior polymorphous corneal dystrophy
    Vivek S Yellore
    Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Invest Ophthalmol Vis Sci 46:1599-603. 2005
    ....
  69. pmc Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
    Binggui Sun
    Gladstone Institute of Neurological Disease, University of California San Francisco, San Francisco, CA 94158, USA
    Neuron 60:247-57. 2008
    ..How Abeta-degrading enzymes are regulated remains largely unknown. Cystatin C (CysC, CST3) is an endogenous inhibitor of cysteine proteases, including cathepsin B (CatB), a recently ..
  70. ncbi Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes
    E Saitoh
    Department of Oral Biochemistry, Nippon Dental University, Niigata, Japan
    Agents Actions Suppl 38:340-8. 1992
    ..as that of other members (the cystatin SN gene at the CST1 locus, the cystatin SA gene at the CST2 locus, the cystatin C gene at the CST3 locus and a cystatin pseudogene at the CSTP1 locus)...
  71. ncbi Cystatin 11: a new member of the cystatin type 2 family
    Katherine G Hamil
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Endocrinology 143:2787-96. 2002
    ..After a 2-h incubation of Escherichia coli with 50 microg/ml recombinant CST11 or CST11Delta2, bacterial colony-forming units were reduced to 30% of control, indicating that both forms have antimicrobial activity...
  72. ncbi Age at onset: an essential variable for the definition of genetic risk factors for sporadic Alzheimer's disease
    Katrin Beyer
    Department of Pathology, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Barcelona, Spain
    Ann N Y Acad Sci 1057:260-78. 2005
    ..polymorphisms of the genes of apolipoprotein E (APOE) and its promoter, cathepsin D, butyrylcholinesterase, cystatin C, methionine synthase, and cystathionine beta-synthase...
  73. doi The hunt for the perfect biomarker for acute kidney injury: back to gamma-trace?
    Josephine P Briggs
    National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    Kidney Int 74:987-9. 2008
    ..Perhaps most importantly, a good marker should aid the testing of interventions to prevent development of AKI and improve management. So, there are very good reasons to get on with it!..
  74. ncbi The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects
    A Rocchi
    Department of Neuroscience, Neurological Clinic, University of Pisa, Italy
    Curr Alzheimer Res 6:224-37. 2009
    ....
  75. pmc Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes
    Chantel D Sloan
    Department of Genetics and Community and Family Medicine, Computational Genetics Laboratory, Dartmouth Medical School, Lebanon, New Hampshire, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1060-9. 2010
    ..The results are consistent with polygenic influences on early neurodegenerative changes and demonstrate the effectiveness of hierarchical clustering in identifying genetic associations among multiple related phenotypic endpoints...
  76. pmc Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    Jason J Corneveaux
    Neurogenomics Division, The Translational Genomics Research Institute Gen, 445 N Fifth Street, Phoenix, AZ 85004, USA
    Hum Mol Genet 19:3295-301. 2010
    ....
  77. ncbi Interleukin-1alpha regulates antimicrobial peptide expression in human keratinocytes
    Mika Bando
    Department of Periodontology and Endodontology, Oral and Maxillofacial Dentistry, Division of Medico Dental Dynamics and Reconstruction, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Immunol Cell Biol 85:532-7. 2007
    ..On the other hand, HaCaT cells expressed mRNA specific for other AMPs, including cystatin 3, adrenomedullin, RNase-7 and mucin 5, which were unaffected by IL-1alpha treatment...
  78. ncbi Regulation of elastolytic proteases in the mouse vagina during pregnancy, parturition, and puerperium
    Cecilia K Wieslander
    Division of Urogynecology and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Biol Reprod 78:521-8. 2008
    ..are increased after 48 h, a time when mRNA levels of protease inhibitors (tissue inhibitor of MMP2 [Timp2], cystatin C [Cst3], and alpha-1 antitrypsin [Serpina1]) are decreased...
  79. doi Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study
    Geoffroy Laumet
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1181-8. 2010
    ..Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses...
  80. ncbi Cleavage of cystatin C in the cerebrospinal fluid of patients with multiple sclerosis
    David N Irani
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 59:237-47. 2006
    ..The diagnosis of multiple sclerosis (MS) can be challenging because of the lack of a specific diagnostic test. Recent advances in proteomics, however, offer new opportunities for biomarker discovery and the study of disease pathogenesis...
  81. ncbi Differential expression of cathepsins and cystatin C in ovine uteroplacental tissues
    G Song
    Department of Animal Science, Texas A and M University, 442 Kleberg Center, 2471 TAMU, College Station, TX 77843 2471, USA
    Placenta 28:1091-8. 2007
    ..b>Cystatin C (CST3) is a secreted inhibitor of lysosomal cysteine proteases cathepsin B (CTSB) and CTSL...
  82. ncbi Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeutic implications
    Francesca M Tumminello
    Laboratory of Experimental Chemotherapy, Department of Surgery and Oncology, Policlinico Universitario P Giaccone, Via del Vespro 129, 90127 Palermo, Italy
    Biomed Pharmacother 62:130-5. 2008
    The clinical significance of serum cathepsin K and cystatin C was assessed in patients with breast cancer (BCa) or prostate cancer (PCa) with confined disease (M0) or bone metastasis (BM)...
  83. ncbi Cystatin C-based formula is superior to MDRD, Cockcroft-Gault and Nankivell formulae in estimating the glomerular filtration rate in renal allografts
    Ammar Qutb
    King Saud Bin Abdulaziz University for Health Sciences, Kingdom of Saudi Arabia
    Exp Clin Transplant 7:197-202. 2009
    ....
  84. doi Cystatin C is independently associated with total and cardiovascular mortality in individuals undergoing coronary angiography. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study
    Rainer P Woitas
    Division of Nephrology, Department of Medicine I, University of Bonn, Germany
    Atherosclerosis 229:541-8. 2013
    b>Cystatin C is a well established marker of kidney function. There is evidence that cystatin C concentrations are also associated with mortality...
  85. doi The relationship between serum fetuin-A, cystatin-C levels, and microalbuminuria in patients with metabolic syndrome
    Bulent Huddam
    Department of Nephrology, Ankara Education and Research Hospital, Ankara, Turkey
    J Clin Lab Anal 27:317-22. 2013
    ..Fetuin-A is a liver derived blood protein that acts as effective inhibitor of soft tissue calcification. Cystatin C is a useful marker in measuring glomerular filtration rate...
  86. doi Does intravenous or oral high-dose N-acetylcysteine in addition to saline prevent contrast-induced nephropathy assessed by cystatin C?
    Mehmet Erturk
    Departments of aCardiology bBiochemistry, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital cDepartment of Cardiology, Faculty of Medicine, Acibadem University, Istanbul, Turkey
    Coron Artery Dis 25:111-7. 2014
    ..v.) or oral N-acetylcysteine (NAC) in preventing contrast-induced nephropathy (CIN) in patients with moderate-to-severe renal insufficiency undergoing intra-arterial interventions...
  87. doi Association of four CpG-SNPs in the vascular-related genes with coronary heart disease
    Leiting Xu
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, 315211 Zhejiang, PR China
    Biomed Pharmacother 70:80-3. 2015
    ....
  88. ncbi Molecular dynamics simulations of human cystatin C and its L68Q varient to investigate the domain swapping mechanism
    Hsuan Liang Liu
    Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1 Sec 3 ZhongXiao E Rd, Taipei, Taiwan 10608
    J Biomol Struct Dyn 25:135-44. 2007
    Human cystatin C variant (L68Q), one of the amyloidgenic proteins, has been shown to form dimeric structure spontaneously via domain swapping and easily cause amyloid deposits in the brains of patients suffering from Alzheimer's disease ..
  89. ncbi The evaluation of cystatin C, IL-1beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children
    A Evren Ulker
    Department of Pediatric Dentistry, Faculty of Dentistry, Gazi University, Ankara, Turkey
    J Periodontol 79:854-60. 2008
    The aim of this study was to evaluate the levels of cystatin C, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in the total saliva and gingival crevicular fluid (GCF) of periodontally healthy children (PHC) and ..
  90. pmc Effects of partner proteins on BCA2 RING ligase activity
    Stephanie Bacopulos
    Sunnybrook Research Institute, Toronto, ON, Canada
    BMC Cancer 12:63. 2012
    ..We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2...
  91. doi Deposition of collagen IV and aggrecan in leptomeningeal arteries of hereditary brain haemorrhage with amyloidosis
    Asbjorg Osk Snorradottir
    Institute for Experimental Pathology at Keldur, University of Iceland, Reykjavik, Iceland
    Brain Res 1535:106-14. 2013
    Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3...
  92. ncbi [Identification of acute leukemia-specific genes from leukemia recipient/sibling donor pairs by distinguishing study with oligonucleotide microarrays]
    Yi Sun
    Hematopoietic Stem Cell Transplantation Center, Hospital 307, Academy of Military Medical Sciences, Beijing 100039, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 12:450-4. 2004
    ..The result has further confirmed that above genes play critical role in the molecular mechanism of acute leukemia...
  93. doi Impact of cystatin C levels on infarct size and hemorrhage volume in acute cerebral stroke
    Dongfang Xiao
    Department of Neurology, The Affiliated Shengjing Hospital of China Medical University, No 36 Sanhao Street, Heping District, Shenyang, 110004, China
    J Neurol 259:2053-9. 2012
    Studies have indicated that serum levels of cystatin C (a sensitive marker of renal function) are significantly associated with cerebral vascular events...
  94. doi Are recently reported biomarkers helpful for early and accurate diagnosis of acute kidney injury?
    Jonatan Barrera-Chimal
    Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Biomarkers 17:385-93. 2012
    ..studied biomarkers are neutrophil gelatinase-associated lipocalin-2, kidney injury molecule-1, interleukin-18, cystatin C, N-acetyl-β-D-glucosaminidase, liver fatty-acid binding protein, and heat shock protein 72...
  95. doi Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment
    Valérie Laurent-Matha
    Institut National de la Santé et de la Recherche Médicale INSERM U896, Université Montpellier1, Montpellier, France
    FASEB J 26:5172-81. 2012
    ..Here, we show by yeast 2-hybrid and degradomics analyses that cystatin C, the most potent natural secreted inhibitor of cysteine cathepsins, both binds to and is a substrate of ..
  96. pmc Antimicrobial activity and molecular mechanism of the CRES protein
    Li Wang
    Department of Histology and Embryology, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS ONE 7:e48368. 2012
    ..Previous studies have revealed that other cystatin family members, such as cystatin 3 and cystatin 11, show antibacterial activity in vitro...
  97. doi Cystatin C for enhancement of risk stratification in non-ST elevation acute coronary syndrome patients with an increased troponin T
    Fons Windhausen
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Chem 55:1118-25. 2009
    We assessed the value of cystatin C for improvement of risk stratification in patients with non-ST elevation acute coronary syndrome (nSTE-ACS) and increased cardiac troponin T (cTnT), and we compared the long-term effects of an early ..
  98. pmc Complexes of amyloid-beta and cystatin C in the human central nervous system
    Weiqian Mi
    Nathan S Kline Institute, Orangeburg, New York, USA
    J Alzheimers Dis 18:273-80. 2009
    A role for cystatin C (CysC) in the pathogenesis of Alzheimer's disease (AD) has been suggested by the genetic linkage of a CysC gene (CST3) polymorphism with late-onset AD, the co-localization of CysC with amyloid-beta (Abeta) in AD ..
  99. pmc Effect of hypo-and euthyroid status on serum cystatin C levels
    Tülin Ayşe Ozden
    Istanbul University Istanbul Faculty of Medicine, Department of Pediatrics, Pediatric Gastroenterolgy Hepatology and Nutrition Unit, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 2:155-8. 2010
    The aim of this study was to investigate the effect of hypo- and euthyroid status on serum cystatin C (CysC) levels in children and to explore whether CysC can be used as a marker of the thyroid status.
  100. doi Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells
    Sabata Martino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Int J Biochem Cell Biol 43:775-83. 2011
    ..Additionally, cystatin C orchestrates cathepsin S expression through a tight but reversible interaction that, based on a screen of adult ..

Research Grants17

  1. The Role of Cystatin C in Acute Kidney Injury
    Jay L Koyner; Fiscal Year: 2013
    ..In order to improve patient outcomes in the setting of AKI we seek to 1) further define the role of Cystatin C (CyC) in 2 distinct settings of AKI 2) improve our understanding of the genetic factors that control CyC ..
  2. Distress, Saliva Composition and Saliva Functions
    JOS BOSCH; Fiscal Year: 2006
    ..By comparing saliva composition and functions in individuals that report low vs. high levels of depressive symptoms, this study investigates a novel pathway linking stress to oral infectious disease. [unreadable] [unreadable]..
  3. BETAAPP MODULATION BY THE ADAPTER PROTEINS FE65 AND X11
    Efrat Levy; Fiscal Year: 2003
    ..Manipulating the interaction of Beta-APP with an effector protein, such as X11 or Fe65, may provide a novel approach for the pharmacological modulation of Beta-APP processing in Alzheimer's disease. ..
  4. Animal models for cerebral amyloid angiopathy
    Efrat Levy; Fiscal Year: 2006
    A L68Q variant cystatin C forms the amyloid deposited in cerebral vessel walls of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type...
  5. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2008
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  6. Elucidating the Kidney's Role in Cardiovascular Risk
    Michael Shlipak; Fiscal Year: 2004
    ....
  7. Chronic Kidney Disease with Benign Prostatic Hyperplasia
    ANDREW RULE; Fiscal Year: 2004
    ..Based on preliminary data, a significant association between BPH surrogate measures and CKD is expected. This study will clarify whether earlier assessment and intervention in BPH is warranted to prevent CKD. ..
  8. Metabolic Syndrome and Cognitive Impairment
    Kristine Yaffe; Fiscal Year: 2005
    ..If elders with metabolic syndrome have increased risk of developing cognitive impairment, this would have important clinical and public health significance. ..
  9. Genetic Regulation of Postnatal Uterine Morphogenesis and Function
    Thomas Spencer; Fiscal Year: 2008
    ..This research will help determine important genes for reproduction and help to design clinical therapies to prevent, identify and treat reproductive problems in women. [unreadable] [unreadable] [unreadable]..
  10. SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENES
    Lars Bertram; Fiscal Year: 2007
    ..While we have devised a strategy that integrates the best available methods to identify complex disease genes, we will routinely adjust our strategy to account for methodologic advances in this rapidly evolving field. ..
  11. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  12. Sex Hormones, Related Polymorphisms & Cognitive Decline
    Kristine Yaffe; Fiscal Year: 2006
    ..Further knowledge of the association between sex hormones, hormone-related polymorphisms and cognitive decline may facilitate preventative strategies to maintain independence and to promote optimum brain aging. ..
  13. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  14. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  15. MECHANISMS REGULATING UTERINE MORPHOGENESIS
    Thomas Spencer; Fiscal Year: 2004
    ....
  16. COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASE
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  17. ESTROGEN COMPOUNDS, COGNITION & DEMENTIA IN OLDER WOMEN
    Kristine Yaffe; Fiscal Year: 2002
    ..This award will foster the applicant's development towards becoming an independent investigator in aging research. ..