CYP7B1

Summary

Gene Symbol: CYP7B1
Description: cytochrome P450 family 7 subfamily B member 1
Alias: CBAS3, CP7B, SPG5A, 25-hydroxycholesterol 7-alpha-hydroxylase, cytochrome P450 7B1, cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1, oxysterol 7-alpha-hydroxylase
Species: human

Top Publications

  1. ncbi Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 281:16625-31. 2006
  2. doi Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain
    N Sugiyama
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, Huddinge, Sweden
    Mol Psychiatry 14:223-32, 117. 2009
  3. ncbi Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 96:466-74. 2004
  4. pmc Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
    Natalia Guillen
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Aragones de Ciencias de la Salud Universidad de Zaragoza Salud del Gobierno de Aragon, Spain
    Physiol Genomics 37:187-98. 2009
  5. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
  6. ncbi Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate
    Jean S Wong
    Department of Cell Biology and Neuroscience, University of California, Riverside 92521, USA
    Toxicol Appl Pharmacol 185:180-96. 2002
  7. ncbi Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye
    Hiromi Ikeda
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Lab Invest 83:349-55. 2003
  8. ncbi Effect of ribavirin, levovirin and viramidine on liver toxicological gene expression in rats
    Che Fang
    Research and Development, Ribapharm Inc, Costa Mesa, CA 92626, USA
    J Appl Toxicol 23:453-9. 2003
  9. ncbi Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes
    Olivier Hennebert
    Laboratoire de Biotechnologie, EA 3199, Conservatoire National des Arts et Metiers, 2 rue Conté, 75003 Paris, France
    J Steroid Biochem Mol Biol 104:326-33. 2007
  10. pmc Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
    Sojin An
    National Research Laboratory of Lipid Metabolism and Atherosclerosis, KRIBB, Daejeon, Korea
    Exp Mol Med 40:407-17. 2008

Research Grants

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. ncbi Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity
    Yukio Yamamoto
    Laboratories of Reproductive and Developmental Toxicology, NIEHS National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biol Chem 281:16625-31. 2006
    ..In addition, ERalpha up-regulated the expression of CYP7B1 and down-regulated the CYP7A1 and CYP8B1, shifting bile acid synthesis toward the acidic pathway to increase the ..
  2. doi Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain
    N Sugiyama
    Department of Biosciences and Nutrition, Karolinska Institute, Novum, Huddinge, Sweden
    Mol Psychiatry 14:223-32, 117. 2009
    ..We used CYP7B1 knockout mice which cannot hydroxylate and inactivate 3betaAdiol...
  3. ncbi Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero
    Michael P Waalkes
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Natl Cancer Inst 96:466-74. 2004
    ....
  4. pmc Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver
    Natalia Guillen
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Instituto Aragones de Ciencias de la Salud Universidad de Zaragoza Salud del Gobierno de Aragon, Spain
    Physiol Genomics 37:187-98. 2009
    ..Ten genes (Fsp27, Aqp4, Cd36, Ly6d, Scd1, Hsd3b5, Syt1, Cyp7b1, and Tff3) showed significant associations among their expressions and the degree of hepatic steatosis...
  5. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
    ..Conversely, inactivation of the CYP7B1 oxysterol 7alpha-hydroxylase, which degrades 25-hydroxycholesterol, decreased serum IgA...
  6. ncbi Gene expression changes induced in mouse liver by di(2-ethylhexyl) phthalate
    Jean S Wong
    Department of Cell Biology and Neuroscience, University of California, Riverside 92521, USA
    Toxicol Appl Pharmacol 185:180-96. 2002
    ..In addition, steroidogenic gene cyp7B1 was downregulated while phospholipid transfer protein and cyp2B9 were induced...
  7. ncbi Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye
    Hiromi Ikeda
    Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Lab Invest 83:349-55. 2003
    ....
  8. ncbi Effect of ribavirin, levovirin and viramidine on liver toxicological gene expression in rats
    Che Fang
    Research and Development, Ribapharm Inc, Costa Mesa, CA 92626, USA
    J Appl Toxicol 23:453-9. 2003
    ..Levovirin decreased the mRNA level of CYP7A1 by fourfold but did not affect the expression of CYP27/CYP7B1 that functions as an alternative pathway for cholesterol metabolism...
  9. ncbi Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes
    Olivier Hennebert
    Laboratoire de Biotechnologie, EA 3199, Conservatoire National des Arts et Metiers, 2 rue Conté, 75003 Paris, France
    J Steroid Biochem Mol Biol 104:326-33. 2007
    Dehydroepiandrosterone (DHEA) is 7alpha-hydroxylated by the cytochome P450 7B1 (CYP7B1) in the human brain and liver...
  10. pmc Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes
    Sojin An
    National Research Laboratory of Lipid Metabolism and Atherosclerosis, KRIBB, Daejeon, Korea
    Exp Mol Med 40:407-17. 2008
    ..expressed mRNA and protein revealed that cholesterol 7alpha-hydroxylase (CYP7A1), oxysterol 7alpha- hydroxylase (CYP7B1), and cholesterol 27-hydroxylase (CYP27) were highly induced by ACAT inhibition...
  11. doi A new marker for early diagnosis of 21-hydroxylase deficiency: 3beta,16alpha,17alpha-trihydroxy-5alpha-pregnane-7,20-dione
    Sofia Christakoudi
    Department of Clinical Biochemistry, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    J Steroid Biochem Mol Biol 121:574-81. 2010
    ..Only traces were found in controls. The likely involvement of oxysterol 7alpha-hydroxylase (CYP7B1) from the 'acidic' pathway of bile acid synthesis and 11beta-hydroxysteroid dehydrogenase-1 in the generation of ..
  12. ncbi [Mechanisms of bile acid biosynthesis regulation--autoregulation by bile acids]
    Areta Hebanowska
    Gdanski Uniwersytet Medyczny, Katedra i Zakład Biochemii, Gdansk
    Postepy Biochem 57:314-23. 2011
    ..Some of those factors influence the activities of other bile acids biosynthesis enzymes--CYP7B1, CYP27A1, CYP8B1...
  13. pmc Multicohort genomewide association study reveals a new signal of protection against HIV-1 acquisition
    Sophie Limou
    Laboratoire Génomique, Bioinformatique, et Applications, EA4627, Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
    J Infect Dis 205:1155-62. 2012
    ..To date, only mutations in CCR5 have been shown to confer resistance to human immunodeficiency virus type 1 (HIV-1) infection, and these explain only a small fraction of the observed variability in HIV susceptibility...
  14. pmc Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting
    Suneng Fu
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 8:e1002902. 2012
    ..The strongest examples of such regulations were the reduction in Cyp7b1 and Slco1a1, molecules involved in bile acid metabolism...
  15. pmc Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease
    April D Lake
    University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721, USA
    Toxicol Appl Pharmacol 268:132-40. 2013
    ..Increased mRNA expression of BAAT and CYP7B1 was observed in contrast to decreased CYP8B1 expression in NASH samples...
  16. doi Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells
    Catherine C Bell
    MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GE, United Kingdom
    Chem Res Toxicol 26:1064-72. 2013
    ..alcohol dehydrogenase 5 (Class III), aldehyde dehydrogenases (ALDH3A2, ALDH6A1, and ALDH9A1), CYP1B1, CYP2R1, CYP7B1, and hydroxysteroid dehydrogenase 10. Over 2600 proteins were identified by mass spectrometry...
  17. pmc Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice
    Jure Acimovic
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    PLoS ONE 8:e68031. 2013
    ..In two patients with a mutation in CYP7B1 and markedly increased levels of 27OHC the sulphated fraction was 8% and 10% respectively...
  18. pmc Cytochromes p450 and skin cancer: role of local endocrine pathways
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, RM525, Memphis, TN 38163, USA
    Anticancer Agents Med Chem 14:77-96. 2014
    ..Cutaneous 7-hydroxylases (CYP7A1, CYP7B1 and CYP39) potentially can produce 7-hydroxy/oxy-steroids/sterols with modifying effects on local tumorigenesis...
  19. pmc 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth
    Qian Wu
    Department of Pediatrics, Division of Pulmonary and Vascular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Rep 5:637-45. 2013
    ..Increased tumor 27HC is correlated with diminished expression of CYP7B1, the 27HC metabolizing enzyme, and reduced expression of CYP7B1 in tumors is associated with poorer patient ..
  20. doi Molecular epidemiology and clinical spectrum of hereditary spastic paraplegia in the Japanese population based on comprehensive mutational analyses
    Hiroyuki Ishiura
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Hum Genet 59:163-72. 2014
    ..Japanese population, we have conducted mutational analyses of 16 causative genes of HSP (L1CAM, PLP1, ATL1, SPAST, CYP7B1, NIPA1, SPG7, KIAA0196, KIF5A, HSPD1, BSCL2, SPG11, SPG20, SPG21, REEP1 and ZFYVE27) using resequencing ..
  21. doi Sensory ataxia as a prominent clinical presentation in three families with mutations in CYP7B1
    Roberto Di Fabio
    Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica, 79, 04100, Latina, Italy
    J Neurol 261:747-51. 2014
    Pathogenic mutations in CYP7B1 account for SPG5, an autosomal recessive hereditary spastic paraplegia characterized by a complex phenotype including visual problems and cerebellar dysfunction...
  22. pmc 24S,25-Epoxycholesterol in mouse and rat brain
    Yuchen Wang
    Clinical Laboratory, Jinan Infectious Disease Hospital, Shandong University, Jinan, Shandong, China Electronic address
    Biochem Biophys Res Commun 449:229-34. 2014
    ..By exploiting knockout mice for the enzyme oxysterol 7α-hydroxylase (Cyp7b1) we show that this enzymes is important for the subsequent metabolism of the 24S,25-epoxide.
  23. pmc Structural characterization of human cholesterol 7α-hydroxylase
    Wolfram Tempel
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada
    J Lipid Res 55:1925-32. 2014
    ..The structure-based mutation T104L in the B' helix, corresponding to the nonpolar residue of CYP7B1, was used to obtain crystals of complexes with cholest-4-en-3-one and with cholesterol oxidation product 7-..
  24. pmc An omics investigation into chronic widespread musculoskeletal pain reveals epiandrosterone sulfate as a potential biomarker
    Gregory Livshits
    aDepartment of Twin Research and Genetic Epidemiology, King s College London, London, United Kingdom bDepartment of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel cNorwich Medical School, University of East Anglia, Norwich, United Kingdom dInstitute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany eInstitute of Health Informatics, University College London UCL, London, United Kingdom fResearch Unit Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany gInstitute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany hGerman Center for Diabetes Research, Neuherberg, Germany iInstitute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Pain 156:1845-51. 2015
    ..This study suggests that steroid hormone abnormalities result from pain rather than causing it, and EAS may provide a biomarker that identifies subgroups at risk of CWP...
  25. pmc Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma
    Haihong Pu
    Department of Medical Oncology, the Third Affiliated Hospital of Harbin Medical University, Haping Road 150 of Nangang District, Harbin, Heilongjiang Province, 150086, China
    World J Surg Oncol 13:323. 2015
    The present study aimed to investigate the expression of CYP27A1, CYP7B1, insulin-like growth factor-1 (IGF-1), glucose-6-phosphate-dehydrogenase (G6PD), glutathione S-transferase P1 (GSTP1), and pyruvate kinase isoform M2 (PKM2) in ..
  26. ncbi The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems
    Aleksandra Rutkowska
    School of Medicine, Dept of Physiology, Trinity College Dublin, 152 160 Pearse Street, Ireland
    Curr Drug Targets . 2016
    ..We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system...
  27. pmc Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma
    Venil N Sumantran
    Department of Biotechnology, Dr M G R Educational and Research Institute University, Chennai, Tamil Nadu 600095, India
    Pharmaceutics 8:. 2016
    ..genes controlling the turnover of vitamin D (CYP27B1, CYP24A1), vitamin A (ALDH1A3, AKR1B10), and cholesterol (CYP7B1), were up-regulated in psoriasis, whereas melanomas showed downregulation of genes regulating turnover of vitamin ..
  28. pmc Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans
    Haizhen Wang
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China
    Genetics 203:241-53. 2016
    ..Mutation of cyp-23A1, encoding a homolog of human cytochrome P450 CYP7B1 that is related to neonatal hemochromatosis, further enhances the elevated expression of ftn-1, sgk-1, and fat ..
  29. ncbi The Interaction of PPARα and CYP7B1 with ERα, β Impacted the Occurrence and Development of Intrahepatic Cholestasis in Pregnant Rats
    Song Zhaoyi
    Department of Obstetrics and Gynecology, Ninth School of Clinical Medicine, Peking University, Beijing, China
    Reprod Sci . 2016
    ..Our findings provide the ERα-centered hypothesis on the mechanisms of ICP. New perspectives are emerging for the treatment of estrogen-induced hepatic complication...
  30. doi Generation of induced pluripotent stem cells (iPSCs) from a hereditary spastic paraplegia patient carrying a homozygous Y275X mutation in CYP7B1 (SPG5)
    Stefan Hauser
    German Center for Neurodegenerative Diseases DZNE, Tuebingen, Germany Electronic address
    Stem Cell Res 17:437-440. 2016
    ..were obtained from a 47-year-old hereditary spastic paraplegia patient carrying a homozygous mutation Y275X in CYP7B1 (Cytochrome P450, Family 7, Subfamily B, Polypeptide 1), responsible for causing hereditary spastic paraplegia ..
  31. ncbi 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles
    Norman B Javitt
    Department of Pediatrics and Medicine, NYU School of Medicine, New York, NY 10016, USA
    J Lipid Res 43:665-70. 2002
    ....
  32. ncbi Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes
    William M Pandak
    Department of Medicine, Veterans Affairs Medical Center and Virginia Commonwealth University, Richmond, VA 23249, USA
    Hepatology 35:1400-8. 2002
    ..CYP27) with subsequent 7alpha-hydroxylation of 27-hydroxycholesterol by oxysterol 7alpha-hydroxylase (CYP7B1)...
  33. ncbi Programming of initial steps in bile acid synthesis by breast-feeding vs. formula-feeding in the baboon
    Glen E Motta
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Lipids 38:1213-20. 2003
    ..liver biopsies were assayed for cholesterol 7alpha-hydroxylase (CYP7A1), 27-hydroxycholesterol-7alpha-hydroxylase (CYP7B1), and cholesterol 27-hydroxylase (CYP27A1)...
  34. pmc Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice
    Xiu Jun Wang
    Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Biochem J 388:857-67. 2005
    ..This was characterized by a reduced expression of Cyp7b1, and elevation of Cyp7a1 and Cyp8b1 expression...
  35. ncbi Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1
    Caroline Muller
    Laboratoire de Biologie, EA 3199, Conservatoire National des Arts et Metiers, 2 rue Conté, 75003 Paris, France
    J Steroid Biochem Mol Biol 99:215-22. 2006
    ..The 7alpha-hydroxy-DHEA produced by the cytochrome CYP7B1 in tissues may exert anti-glucocorticoid effects through interference with the 11beta-HSD1-mediated cortisone ..
  36. ncbi Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice
    Anna Kinoshita
    Department of Pathology, Osaka City University Medical School, Osaka 545 8585, Japan
    Cancer Sci 98:803-14. 2007
    ..Marked induction of Pola1, Cyp7b1, Ndfua3, Mmp13 and other genes specific to cell proliferation, cell signaling and xenobiotic metabolism in the ..
  37. pmc The emerging role of nuclear receptor RORalpha and its crosstalk with LXR in xeno- and endobiotic gene regulation
    Taira Wada
    Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Biol Med (Maywood) 233:1191-201. 2008
    ..Among ROR responsive genes, we identified oxysterol 7alpha-hydroxylase (Cyp7b1), which plays a critical role in the homeostasis of cholesterol, as a RORalpha target gene...
  38. pmc Mechanisms of disease: Inborn errors of bile acid synthesis
    Shikha S Sundaram
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine and The Children s Hospital, CO 80045, USA
    Nat Clin Pract Gastroenterol Hepatol 5:456-68. 2008
    ..Failure to diagnose any of these conditions can result in liver failure or progressive chronic liver disease. If recognized early, many patients can have a remarkable clinical response to oral bile acid therapy...
  39. doi CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5
    Cyril Goizet
    INSERM UPMC UMR_S 975 ex U679, CRicm, Bat Pharmacie, Pitie Salpetriere Hospital, 47 Boulevard de l Hopital, Paris Cedex 13, France
    Brain 132:1589-600. 2009
    ..Very recently, five mutations in the CYP7B1 gene, encoding a cytochrome P450 oxysterol 7-alpha hydroxylase and expressed in brain and liver, have been found ..
  40. doi Effects of CYP7B1-mediated catalysis on estrogen receptor activation
    Hanna Pettersson
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, S 75123 Uppsala, Sweden
    Biochim Biophys Acta 1801:1090-7. 2010
    ..The current study examines the role of CYP7B1-mediated catalysis for activation of ER...
  41. doi Testosterone-induced permanent changes of hepatic gene expression in female mice sustained during Plasmodium chabaudi malaria infection
    Denis Delic
    Division of Molecular Parasitology, Department of Biology and Centre for Biological and Medical Research, Heinrich Heine University Duesseldorf, Universitaetstrasse 1, 40225 Duesseldorf, Germany
    J Mol Endocrinol 45:379-90. 2010
    ..Cyp3a41, Cyp3a44, Fmo3, Sult2a2, Sult3a1, and BC014805 were repressed, while the male-prevalent genes Cyp2d9, Cyp7b1, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, and Slco1a1 were upregulated...
  42. doi Clinical phenotype variability in patients with hereditary spastic paraplegia type 5 associated with CYP7B1 mutations
    A Arnoldi
    E Medea Scientific Institute, Laboratory of Molecular Biology, Bosisio Parini, Lecco, Italy
    Clin Genet 81:150-7. 2012
    Spastic paraplegia type 5 (SPG5) is caused by mutations in CYP7B1, a gene encoding the cytochrome P-450 oxysterol 7-α-hydroxylase, CYP7B1, an enzyme implicated in the cholesterol metabolism...
  43. doi Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
    N A Schlipf
    Department of Medical Genetics, Institute of Human Genetics, Tubingen, Germany
    Clin Genet 80:148-60. 2011
    ..Amplicon libraries of the CYP7B1-(SPG5) and SPG7-gene were generated followed by a pooled next-generation sequencing (NGS) approach...
  44. pmc Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e28632. 2011
    ..To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use...
  45. doi Influence of depleted uranium on hepatic cholesterol metabolism in apolipoprotein E-deficient mice
    M Souidi
    Institut de Radioprotection et de Surete Nucleaire IRSN, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP no 17, F 92262 Fontenay aux Roses Cedex, France
    J Steroid Biochem Mol Biol 129:201-5. 2012
    ..in the liver especially focused on the gene expressions of cholesterol-catabolising enzymes (CYP7A1, CYP27A1 and CYP7B1), as well as those of associated nuclear receptors (LXRα, FXR, PPARα, and SREBP 2)...
  46. pmc Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins
    Meiyao Wang
    Institute for Bioscience and Biotechnology Research, Rockville, Maryland 20850, USA
    Anal Chem 84:5186-91. 2012
    ..Both, weakly associated (CPR and FdR) and tightly associated (CYP7B1, CYP11A1, CYP27A1, and CYP46A1) membrane proteins were quantified...
  47. ncbi Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet
    Koji Nojima
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Endocr J 60:261-74. 2013
    ..C3H mice, hepatic expression levels of Kat2b (transcriptional regulation), Hsd3b5 (steroid hormone metabolism) and Cyp7b1 (bile acid metabolism) were initially lower in RD-fed NSY mice, and were further decreased in HSD-fed NSY mice...
  48. doi Gene expression profile in chronic mouse liver injury caused by long-term exposure to CeCl3
    Jie Cheng
    Medical College, Soochow University, Suzhou 215123, People s Republic of China
    Environ Toxicol 29:837-46. 2014
    ..Cyp4a12a and great suppression of Cdkn1a resulted in hepatocyte apoptosis, marked elevation of Cel, and Cyp7b1 expression caused the metabolic disorders in mouse liver after long-term CeCl3 exposure...
  49. doi Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating
    Richard Lathe
    State University of Pushchino, Prospekt Nauki, Pushchino 142290, Moscow Region, Russia Pushchino Branch of the Institute of Bio Organic Chemistry, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia Pieta Research, PO Box 27069, Edinburgh EH10 5YW, UK Electronic address
    Steroids 82:14-22. 2014
    ..gain receptor access - exemplified by 11β-HSD gating cortisol access to the mineralocorticoid receptor, and P450 CYP7B1 gating Adiol access to ER...
  50. doi Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages
    Inga Preuss
    Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Basel, Switzerland
    Biochem Biophys Res Commun 446:663-8. 2014
    ..such as cholesterol 25-hydroxylase (CH25H), sterol 27-hydroxylase (CYP27A1), and oxysterol 7α-hydroxylase (CYP7B1)...
  51. doi Clinical and genetic analysis of Taiwanese patients with hereditary spastic paraplegia type 5
    M Y Lan
    Center for Parkinson s Disease, Department of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Eur J Neurol 22:211-4. 2015
    ..Spastic paraplegia type 5 (SPG5) is an autosomal recessive (AR) hereditary spastic paraplegia (HSP) associated with pure or complicated phenotypes. This study aimed to screen SPG5 in Taiwanese HSP patients...
  52. pmc The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha
    Michihisa Umetani
    Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 20:172-82. 2014
    ..27-hydroxycholesterol (27HC) is an abundant oxysterol metabolized by CYP7B1. How 27HC impacts vascular health is unknown...
  53. doi Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis
    Grzegorz Wicher
    Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    J Steroid Biochem Mol Biol 145:21-7. 2015
    ..In the current study we examined effects of estrogens on steroid metabolism catalyzed by CYP7B1 and other enzymes in primary cultures of rat astrocytes...
  54. doi Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone
    Mohamed A Dkhil
    Department of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt Electronic address
    J Steroid Biochem Mol Biol 145:121-30. 2015
    ..g. the T-upregulated male-predominant genes Cyp7b1, Cyp2d9, Cyp4a10, Ugt2b1, Ugt2b38, Hsd3b5, Slco1a1 as well as the T-downregulated female-predominant genes Cyp2b9, ..
  55. ncbi Effect of hyperinsulinemia and type 2 diabetes-like hyperglycemia on expression of hepatic cytochrome p450 and glutathione s-transferase isoforms in a New Zealand obese-derived mouse backcross population
    Georgia J Pass
    Institute for Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Wendlingweg 2, D 52072 Aachen, Germany
    J Pharmacol Exp Ther 302:442-50. 2002
    ..Furthermore, expression of Cyp1a2, Cyp7b1, Gstm3, and Gstm6 was reduced in both diabetic and insulin resistant mice...
  56. doi Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases
    Gregor Lorbek
    Center for Functional Genomics and Bio Chips, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    FEBS J 279:1516-33. 2012
    ..In line with this, Cyp7b1 knockouts are also apparently normal, whereas human CYP7B1 mutations lead to a congenital bile acid synthesis ..
  57. pmc Estrogen receptor beta dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries
    Kristen L Zuloaga
    Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ 85004 2157, United States
    Steroids 77:835-44. 2012
    ..for the synthesis and metabolism of 3β-diol [3alpha-hydroxysteroid dehydrogenase (HSD), 3β-HSD, 17β-HSD, CYP7B1] was detected. In addition, the expression of AR, ERα, and ERβ mRNA was detected...
  58. pmc Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses
    Tangsheng Yi
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 37:535-48. 2012
    ..7α,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7...
  59. ncbi A clinical and genetic study of SPG5A linked autosomal recessive hereditary spastic paraplegia
    P A Wilkinson
    Department of Clinical Neurosciences, Royal Free and University College Medical School, London, UK
    Neurology 61:235-8. 2003
    ..Linkage to the previously described SPG5A locus was established with maximum multipoint lod score of 4.84. The locus was refined to a 23...
  60. ncbi Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster
    Maamar Souidi
    Laboratory of Physiology and Nutrition, Bâtiment 447, Universite Paris Sud, 91405 Orsay Cedex, France
    Can J Physiol Pharmacol 81:854-63. 2003
    ..Its effects on SR-BI protein levels are organ dependent. The properties of 27OH-Chol or its metabolites on cholesterol metabolism probably result from the activation of specific transcription factors...
  61. doi Neonatal cholestatic liver disease in an Asian patient with a homozygous mutation in the oxysterol 7alpha-hydroxylase gene
    Isao Ueki
    Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Pediatr Gastroenterol Nutr 46:465-9. 2008
  62. doi Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance
    Josef Finsterer
    Krankenanstalt Rudolfstiftung, Wien, Austria
    J Neurol Sci 318:1-18. 2012
    ..KIAA1840 (SPG11) gene whereas the 15 other genes are rarely mutated and account for SPGs in single families yet (CYP7B1 (SPG5), SPG7 (SPG7), ZFYVE26 (SPG15), ERLIN2 (SPG18), SPG20 (SPG20), ACP33 (SPG21), KIF1A (SPG30), FA2H (SPG35), ..
  63. doi Testosterone effect on the expression of genes that mediate testosterone metabolism and genes that mediate the effect of those metabolites on the prostate
    Falah Shidaifat
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
    Life Sci 91:194-8. 2012
    ..aim of this study was to investigate the effect of testosterone treatment on the proliferation index and the mRNA expression levels of 5α-reductase, CYP7B1, androgen receptor (AR), and estrogen receptor β (ΕRβ) in the canine prostate.
  64. doi Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia
    Kishore R Kumar
    Department of Neurogenetics, Kolling Institute of Medical Research, Royal North Shore Hospital and The University of Sydney, Pacific Hwy, St Leonards, Sydney, NSW, 2065, Australia
    J Neurol 260:2516-22. 2013
    ..one patient with SPG31, four with SPG7 (with one novel SPG7 mutation) and two with SPG5 (including two novel CYP7B1 frameshift mutations)...
  65. doi Sex differences in the circadian variation of cytochrome p450 genes and corresponding nuclear receptors in mouse liver
    Yuan Fu Lu
    Key Laboratory of Basic Pharmacology of Guizhou, Zunyi Medical College, Zunyi, China
    Chronobiol Int 30:1135-43. 2013
    ..b>Cyp7b1(male-predominant) and Cyp2a4 (female-predominant) both showed circadian variation...
  66. pmc Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats
    Qiong N Zhu
    Department of Pharmacology and Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College, Zunyi, China
    Peerj 1:e143. 2013
    ..Expression of Cyp8b1, Cyp27a1 and Cyp7b1 was also higher during lactation...
  67. ncbi Linkage of 'pure' autosomal recessive familial spastic paraplegia to chromosome 8 markers and evidence of genetic locus heterogeneity
    A Hentati
    Department of Neurology, Northwestern University Medical School, Chicago, IL 60611
    Hum Mol Genet 3:1263-7. 1994
    ..Identification of the RFSP gene on chromosome 8 will help in understanding the genetic factors in motor neuron degeneration...
  68. pmc Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase
    M Schwarz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 271:18024-31. 1996
    ..In older animals, an alternate pathway of bile acid synthesis involving an inducible oxysterol 7alpha-hydroxylase plays a crucial role in lipid and bile acid metabolism...
  69. ncbi Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA
    M Schwarz
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 272:23995-4001. 1997
    ..Here, we show that a mouse hepatic oxysterol 7alpha-hydroxylase is encoded by Cyp7b1, a cytochrome P450 cDNA originally isolated from the hippocampus...
  70. ncbi Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)
    H Ishida
    Department of Biochemistry, Hiroshima University School of Dentistry, Minami Ku, Hiroshima, 734 8553, Japan
    J Biochem 126:19-25. 1999
    ..The enhanced CYP8B mRNA expression in streptozotocin-induced diabetic rats was significantly decreased by insulin within 3 h of its administration. These facts demonstrate a regulatory role of insulin in CYP8B expression as a suppressor...
  71. ncbi Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    Z Wu
    Department of Biochemistry and Molecular Pathology, Northeastern Ohio Universities College of Medicine, P O Box 95, Rootstown, OH 44272, USA
    J Lipid Res 40:2195-203. 1999
    ..The cloned human oxysterol 7alpha-hydroxylase (CYP7B1) cDNA encodes a polypeptide of 506 amino acid residues that shares 40% sequence identity to human cholesterol ..
  72. ncbi Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
    J Li-Hawkins
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 275:16543-9. 2000
    ..of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus...
  73. ncbi Disruption of the oxysterol 7alpha-hydroxylase gene in mice
    J Li-Hawkins
    Departments of Molecular Genetics and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9046, USA
    J Biol Chem 275:16536-42. 2000
    ..with a sexually dimorphic expression pattern, were constructed by the introduction of a null mutation at the Cyp7b1 locus...
  74. ncbi 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A)
    M Norlin
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, S 751 23 Uppsala, Sweden
    J Lipid Res 41:1629-39. 2000
    ....
  75. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
    ..Thus, our data indicate that LXRbeta has no complete overlapping function compared with LXRalpha in the liver...
  76. pmc cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate
    C Martin
    Molecular Endocrinology, Molecular Medicine Centre, Western General Hospital and Centre for Neuroscience, University of Edinburgh, Edinburgh EH4 2XU, Scotland, UK
    Biochem J 355:509-15. 2001
    ..We recently described a novel cytochrome P450 enzyme, cyp7b1, strongly expressed in the hippocampus of rodent brain, which catalyses the metabolism of DHEA, pregnenolone and ..
  77. ncbi In vivo and in vitro regulation of sterol 27-hydroxylase in the liver during the acute phase response. potential role of hepatocyte nuclear factor-1
    R A Memon
    Departments of Medicine, University of California, San Francisco and the Metabolism Section, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:30118-26. 2001
    ..A decrease in bile acid synthesis in liver would reduce cholesterol catabolism and thereby contribute to the increase in hepatic lipoprotein production that is induced by LPS and cytokines...
  78. ncbi The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism
    Jack Phan
    Department of Medicine, UCLA and the Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    J Biol Chem 277:469-77. 2002
    ..Genetic analysis of serum bile acid levels revealed co-segregation with Diet1, indicating that this locus is likely responsible for both increased bile acid excretion and resistance to hypercholesterolemia in B6By mice...
  79. ncbi Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences
    Maria Norlin
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, Box 578, SE 751 23 Uppsala, Sweden
    J Lipid Res 43:721-31. 2002
    The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3beta-hydroxy-Delta(5)-C(27)-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages...
  80. pmc An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth
    Zhang Weihua
    Department of Medical Nutrition, Karolinska Institute, Novum, S 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 99:13589-94. 2002
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-diol (..
  81. ncbi Characterization of the dehydroepiandrosterone (DHEA) metabolism via oxysterol 7alpha-hydroxylase and 17-ketosteroid reductase activity in the human brain
    Stephan Steckelbroeck
    Department of Clinical Biochemistry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Neurochem 83:713-26. 2002
    ..5 and 8.0 and a mean KM value of 5.4 micro m, corresponding with the presence of the oxysterol 7alpha-hydroxylase CYP7B1. Real-time RT-PCR analysis verified high levels of CYP7B1 mRNA expression in the human CNS...
  82. ncbi Gene expression profiles associated with inflammation, fibrosis, and cholestasis in mouse liver after griseofulvin
    Timothy W Gant
    MRC Toxicology Unit, Hodgkin Building, PO Box 138, University of Leicester, Leicester, LE1 9HN UK
    EHP Toxicogenomics 111:37-43. 2003
    ..A potential decrease in bile acid and steroid biosynthesis was indicated by the decreased expression of Cyp7b1 and Hsd3b4, respectively. DNA damage was indicated by induction of GADD45...
  83. ncbi Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat
    Shunlin Ren
    Department of Medicine, Veterans Affairs Medical Center and Virginia Commonwealth University, Richmond, VA 23249, USA
    Metabolism 52:636-42. 2003
    ..of cholesterol by 27-hydroxylase (CYP27), followed by 7alpha-hydroxylation by oxysterol 7alpha-hydroxylase (CYP7B1)...
  84. ncbi Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1alpha)-deficient mice
    Connie Cheung
    Laboratory of Metabolism, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Biochem Pharmacol 66:2011-20. 2003
    ..encoding CYPs involved in fatty acid and bile acid metabolism characterized by a reduction in the expression of Cyp7b1, and Cyp27 as well as elevations in Cyp4a1/3, Cyp7a1, Cyp8b1, and Cyp39a1 expression...
  85. ncbi Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..binding protein-1, superoxide dismutase, glutathione S-transferases, and CYP2A4, and the depressed expression of CYP7B1. Real-time RT-PCR analysis largely confirmed these findings...
  86. ncbi CYP7B generates a selective estrogen receptor beta agonist in human prostate
    Cecile Martin
    Endocrinology Unit, Department of Oncology, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Clin Endocrinol Metab 89:2928-35. 2004
    ..By this reaction, an ERbeta-specific agonist, 7HD, is produced. Therefore, CYP7B may be a novel regulator of the androgens/estrogenic balance within the prostate...
  87. pmc Early onset of puberty and early ovarian failure in CYP7B1 knockout mice
    Yoko Omoto
    Department of Medical Nutrition, Karolinska Institute, 141 86 Huddinge, Sweden
    Proc Natl Acad Sci U S A 102:2814-9. 2005
    b>CYP7B1 is the enzyme responsible for hydroxylation and termination of the estrogenic actions of the androgen metabolite, 5alpha-androstane-3beta, 17beta-diol (3betaAdiol)...
  88. ncbi Feedback regulation of bile acid synthesis in human liver: importance of HNF-4alpha for regulation of CYP7A1
    Anna Abrahamsson
    Department of Medicine, Division of Gastroenterology and Hepatology, Karolinska Institute K63, Karolinska University Hospital Huddinge, S 14186 Stockholm, Sweden
    Biochem Biophys Res Commun 330:395-9. 2005
    ..Treatment with CDCA decreased the mRNA levels of CYP7A1 by about 70%. The mRNA levels of CYP8B1, CYP27A1, and CYP7B1 were not significantly altered in the treated groups...
  89. pmc Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Lipid Res 47:215-27. 2006
    ..These studies reveal that HNF4alpha plays a central role in BA homeostasis by regulation of genes involved in BA biosynthesis, including hydroxylation and side chain beta-oxidation of cholesterol in vivo...
  90. ncbi Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Mail Drop F0 09, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 213:216-23. 2006
    ..Arsenic/TPA also decreased the expression of BRCA1, betaine-homocysteine methyltransferase, CYP7B1, CYP2F2 and insulin-like growth factor-1 in normal and cancerous livers...
  91. ncbi Regulation of steroid hydroxylase CYP7B1 by androgens and estrogens in prostate cancer LNCaP cells
    Wanjin Tang
    Department of Pharmaceutical Biosciences, Division of Biochemistry, University of Uppsala, Box 578, S 751 23 Uppsala, Sweden
    Biochem Biophys Res Commun 344:540-6. 2006
    The present study reports effects of androgens and estrogens on human CYP7B1 transcription in prostate cancer LNCaP cells...
  92. ncbi The cytochromes P450 (CYP) response to allergic inflammation of the lung
    Ivaylo Stoilov
    Department of Pharmacology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Arch Biochem Biophys 456:30-8. 2006
    ..of Cyp2e1, Cyp2f2, Cyp2j6, Cyp4b1, Cyp8a1 and Cypor were decreased while the mRNA levels of Cyp4f18, Cyp5a1 and Cyp7b1 were elevated. With resolution of the inflammation the expression patterns returned to normal...
  93. ncbi Activation of LXRs prevents bile acid toxicity and cholestasis in female mice
    Hirdesh Uppal
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Hepatology 45:422-32. 2007
    ..Activation of LXRs a l so suppresses expression of oxysterol 7alpha-hydroxylase (Cyp7b1), which may lead to increased levels of LXR-activating oxysterols.
  94. ncbi Regulation and expression of human CYP7B1 in prostate: overexpression of CYP7B1 during progression of prostatic adenocarcinoma
    Mats Olsson
    Department of Urology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Prostate 67:1439-46. 2007
    ..We hypothesized that CYP7B1 expression is increased in prostate tumors and that promoter methylation contributes to the regulation of CYP7B1 ..
  95. ncbi [Association between cholesterol 7alpha-hydroxylase -204A/C gene polymorphism and endogenous hypertriglyceridemia in Chinese]
    Yan Qiao
    Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:432-6. 2007
    ....
  96. ncbi 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    Michihisa Umetani
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9050, USA
    Nat Med 13:1185-92. 2007
    ..pharmacologic administration or genetic manipulation (by knocking out the gene encoding the catabolic enzyme CYP7B1) decreased estrogen-dependent expression of vascular nitric oxide synthase and repressed carotid artery ..
  97. ncbi Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)
    Taira Wada
    Center for Pharmacogenetics, 633 Salk Hall, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pharmacol 73:891-9. 2008
    ..In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, bile acids, and oxysterols...
  98. ncbi Long-term phytosterol treatment alters gene expression in the liver of apo E-deficient mice
    Zuyuan Xu
    Department of Human Nutritional Sciences, University of Manitoba, Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
    J Nutr Biochem 19:545-54. 2008
    ..001), Ppargc1b (PGC-1beta; a coactivator of sterol-regulatory element-binding proteins; 1.66-fold; P=.007) and Cyp7B1 (1.81-fold; P=.025)...

Research Grants13

  1. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2010
    ..It is hoped that the development of selective LXR agonists may represent a novel strategy for the prevention and treatment of APAP-induced hepatotoxicity. ..
  2. Philip W Shaul; Fiscal Year: 2014
    ..Recent preliminary studies in mice null for Cyp7b1, which metabolizes 27HC, suggest that 27HC may also promote atherogenesis, attenuate E2-induced protection from ..
  3. The Regulation of Human Hydroxysteroid Sulfotransferase by Nuclear Receptor ROR
    Wen Xie; Fiscal Year: 2012
    ..It has recently been reported that certain hepatic CYP enzymes, such as CYP7B1 and CYP2C8, can be transcriptionally regulated by RORs, suggesting a broader role of these orphan receptors in ..
  4. Envronment-Sensitive genes in motoneuron degeneration
    Teepu Siddique; Fiscal Year: 2010
    ..Mutations in the second gene, CYP7B1, are caused in corticospinal degeneration in a form of hereditary spastic paraplegia (SPG5A)...
  5. Genes and Genetic Models in Motor Neuron Disorders
    Teepu Siddique; Fiscal Year: 2007
    ..genes for a more common form of recessive FALS (ALS5) on chromosome 15q15-q21 and a common form of recessive HSP (SPG5A) on chromosome 8q...
  6. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  7. Meeting: Mechanisms of Cell Death
    Zahra Zakeri; Fiscal Year: 2004
    ..We expect that this meeting will lead to further publications. ..
  8. Scientific Meeting: Mechanisms of Cell Death
    Zahra Zakeri; Fiscal Year: 2006
    ..We are currently negotiating publication arrangements. NIH funds will be used to support speakers and facilities. Future meetings in France and China are planned. [unreadable] [unreadable] [unreadable]..
  9. Cell Death Society Symposium on Targeting Cell Death Pathways for Human Diseases
    Zahra Zakeri; Fiscal Year: 2008
    ..Our meeting will address the idea of how to go from basic research to development of methods for therapeutic interventions and targeting cell death pathways for human diseases. [unreadable] [unreadable] [unreadable]..
  10. Environmental factors in the etiology of glaucoma
    John Schenkman; Fiscal Year: 2006
    ..Our hypothesis has the potential to clarify the basic mechanisms of developmental toxicity operating during eye development and provides an opportunity to develop screening panels for assessment of ocular toxicity. ..
  11. Phase II UDP-glucuronosyltransferases by PXR
    Wen Xie; Fiscal Year: 2007
    ..These include bilirubin and hormonal homeostasis, drug metabolism, and chemical carcinogenesis. ..
  12. PXR Controlled Bile Acid Detoxification in Colon Cancer
    Wen Xie; Fiscal Year: 2008
    ..It is anticipated that the development of selective PXR agonists may represent a novel strategy to eliminate toxic bile acids and to prevent colon cancer. ..
  13. Regulation of Sulfotransferases by LXR and its Implication in Pathophysiology
    Wen Xie; Fiscal Year: 2011
    ..Since estrogens are prerequisites for breast cancer, delineating the regulatory effects of LXRs on EST/SULT1E1 expression may have a broader significance in the understanding of breast cancer prevention and treatment. ..