CYP4V2

Summary

Gene Symbol: CYP4V2
Description: cytochrome P450 family 4 subfamily V member 2
Alias: BCD, CYP4AH1, cytochrome P450 4V2, cytochrome P450, family 4, subfamily V, polypeptide 2, docosahexaenoic acid omega-hydroxylase CYP4V2
Species: human

Top Publications

  1. pmc Genetic linkage of Bietti crystallin corneoretinal dystrophy to chromosome 4q35
    X Jiao
    Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 67:1309-13. 2000
  2. pmc Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2
    Anren Li
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 74:817-26. 2004
  3. ncbi Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy
    Yuko Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Am J Ophthalmol 139:894-9. 2005
  4. ncbi CYP4V2 mutations in two Japanese patients with Bietti's crystalline dystrophy
    Tamaki Gekka
    Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
    Ophthalmic Res 37:262-9. 2005
  5. ncbi Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy
    Minghua Shan
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Mol Vis 11:738-43. 2005
  6. ncbi Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations
    Kelvin Y C Lee
    Singapore National Eye Centre
    Invest Ophthalmol Vis Sci 46:3812-6. 2005
  7. ncbi Clinical and molecular findings in three Japanese patients with crystalline retinopathy
    Zi Bing Jin
    Department of Ophthalmology and Visual Science, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Jpn J Ophthalmol 50:426-31. 2006
  8. ncbi Bietti crystalline corneoretinal dystrophy associated with CYP4V2 gene mutations
    Makoto Nakamura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 572:49-53. 2006
  9. ncbi Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 48:5212-20. 2007
  10. pmc Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase
    Mariko Nakano
    Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 37:2119-22. 2009

Research Grants

  1. Stephen J Small; Fiscal Year: 2016
  2. Translational repressors in Drosophila development
    Robin P Wharton; Fiscal Year: 2013
  3. Engineering enzymes for anti-tumor suicide gene therapy
    Barry L Stoddard; Fiscal Year: 2010
  4. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
  5. In Vivo Evaluation of Presbyopia
    Kathryn Richdale; Fiscal Year: 2013
  6. Dual Action Inhibitors of Gyrase Beta and Histidine Kinases as Broad-Spectrum Ant
    Peter B Madrid; Fiscal Year: 2010
  7. Jun Ma; Fiscal Year: 2015
  8. Baylor's Scientific Training Program for Dental Academic Researchers: B-STARS
    RENA N D'SOUZA; Fiscal Year: 2012
  9. Baylor's Program for Bioengineering Sciences and Translational Research "B-BEST"
    RENA N D apos SOUZA; Fiscal Year: 2010
  10. Mechanisms of Response and Relapse in Rituximab-treated Myositis Patients
    Chester V Oddis; Fiscal Year: 2013

Detail Information

Publications183 found, 100 shown here

  1. pmc Genetic linkage of Bietti crystallin corneoretinal dystrophy to chromosome 4q35
    X Jiao
    Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 67:1309-13. 2000
    Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive retinal degeneration characterized by multiple glistening intraretinal dots scattered over the fundus, degeneration of the retina, and sclerosis of the choroidal ..
  2. pmc Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2
    Anren Li
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 74:817-26. 2004
    ..by D4S2924 by linkage and haplotype analysis; mutations were found in the novel CYP450 family member CYP4V2 in 23 of 25 unrelated patients with BCD tested...
  3. ncbi Screening for mutations in CYP4V2 gene in Japanese patients with Bietti's crystalline corneoretinal dystrophy
    Yuko Wada
    Department of Ophthalmology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
    Am J Ophthalmol 139:894-9. 2005
    To describe the clinical and genetic characteristics of six Japanese families with Bietti's crystalline corneoretinal dystrophy (BCD).
  4. ncbi CYP4V2 mutations in two Japanese patients with Bietti's crystalline dystrophy
    Tamaki Gekka
    Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan
    Ophthalmic Res 37:262-9. 2005
    ..The purpose of this study was to report mutations in the CYP4V2 gene (encoding a ubiquitously-expressed 525-amino acid sequence belonging to the CYP450 family) and to investigate ..
  5. ncbi Novel mutations in the CYP4V2 gene associated with Bietti crystalline corneoretinal dystrophy
    Minghua Shan
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Mol Vis 11:738-43. 2005
    ..Recently mutations in a new gene CYP4V2, encoding a protein belonging to a novel member of the cytochrome P450 family, have been identified as the cause ..
  6. ncbi Characterization of Bietti crystalline dystrophy patients with CYP4V2 mutations
    Kelvin Y C Lee
    Singapore National Eye Centre
    Invest Ophthalmol Vis Sci 46:3812-6. 2005
    Mutations of the CYP4V2 gene, a novel family member of the cytochrome P450 genes on chromosome 4q35, have recently been identified in patients with Bietti crystalline dystrophy (BCD)...
  7. ncbi Clinical and molecular findings in three Japanese patients with crystalline retinopathy
    Zi Bing Jin
    Department of Ophthalmology and Visual Science, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Jpn J Ophthalmol 50:426-31. 2006
    To identify CYP4V2 mutations in three unrelated Japanese patients with Bietti crystalline corneoretinal dystrophy (BCD).
  8. ncbi Bietti crystalline corneoretinal dystrophy associated with CYP4V2 gene mutations
    Makoto Nakamura
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Adv Exp Med Biol 572:49-53. 2006
    ..Recent studies have demonstrated that the CYP4V2 gene which encodes a CYP450 family protein is the causative gene of the disease...
  9. ncbi Genotype phenotype analysis of Bietti's crystalline dystrophy in patients with CYP4V2 mutations
    Timothy Y Y Lai
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong
    Invest Ophthalmol Vis Sci 48:5212-20. 2007
    To evaluate the genotypic and phenotypic correlations of Bietti's crystalline dystrophy (BCD) in patients with the CYP4V2 gene by mutation screening and clinical and electrophysiological assessment.
  10. pmc Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase
    Mariko Nakano
    Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195 7610, USA
    Drug Metab Dispos 37:2119-22. 2009
    Bietti's crystalline dystrophy is an ocular disease that is strongly associated with polymorphisms in the CYP4V2 gene...
  11. pmc An atypical form of Bietti crystalline dystrophy
    Settimio Rossi
    Department of Ophthalmology, Second University of Naples, Napoli, Italy
    Ophthalmic Genet 32:118-21. 2011
    ..To describe clinical and functional features of a patient with Bietti crystalline dystrophy and atypical electroretinogram responses...
  12. pmc Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states
    Edward J Kelly
    Department of Pharmaceutics, University of Washington, Seattle, WA 98195, USA
    Mol Interv 11:124-32. 2011
    ..Human CYP4V2 and CYP4F22 are two such orphan P450s that are strongly linked to ocular andskin disease, respectively...
  13. doi Identification of CYP4V2 mutation in 21 families and overview of mutation spectrum in Bietti crystalline corneoretinal dystrophy
    Xueshan Xiao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Biochem Biophys Res Commun 409:181-6. 2011
    ..BCD is caused by CYP4V2 mutations...
  14. pmc Molecular screening of the CYP4V2 gene in Bietti crystalline dystrophy that is associated with choroidal neovascularization
    Gandra Mamatha
    SN ONGC Department of Genetics and Molecular Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Mol Vis 17:1970-7. 2011
    ..The disease is caused by mutation in the cytochrome p450, family 4, subfamily v, polypeptide 2 (CYP4V2) gene. Choroidal neovascularization (CNV) is a rare event in BCD. We report two cases of BCD associated with CNV...
  15. pmc Clinical and molecular findings in three Lebanese families with Bietti crystalline dystrophy: report on a novel mutation
    Nour Maya N Haddad
    Service d Ophtalmologie, Hotel Dieu de France Hospital, Beirut, Lebanon
    Mol Vis 18:1182-8. 2012
    ..rare autosomal recessive disorder caused by mutation of the cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) gene and characterized by retinal pigmentary abnormalities and scattered deposits of crystals in the retina and ..
  16. pmc Clinical and genetic features in Italian Bietti crystalline dystrophy patients
    Settimio Rossi
    Department of Ophthalmology, Seconda Universita degli Studi di Napoli, Via S Panini, 5, Naples 80131, Italy
    Br J Ophthalmol 97:174-9. 2013
    The aim of the study was to describe the clinical and genetic features of 15 Italian patients with Bietti crystalline dystrophy (BCD).
  17. doi A novel mutation in the CYP4V2 gene in a Chinese patient with Bietti's crystalline dystrophy
    Yanping Song
    Department of Ophthalmology, Wuhan General Hospital of Guangzhou Military Command, Wuhan, 430070, China
    Int Ophthalmol 33:269-76. 2013
    ..It is known that mutations in the CYP4V2 gene result in BCD...
  18. doi Genotype-phenotype analysis of Bietti crystalline dystrophy in a family with the CYP4V2 Ile111Thr mutation
    Gerardo Pedro García-García
    Department of Ophthalmology, University General Hospital of Alicante, Alicante, Spain
    Cornea 32:1002-8. 2013
    ..The purposes of this study were to evaluate the genotypic and phenotypic correlations of Bietti crystalline dystrophy and to investigate the utility of in vivo corneal confocal microscopy in diagnosing this disorder...
  19. doi Detailed phenotypic and genotypic characterization of bietti crystalline dystrophy
    Stephanie Halford
    Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, United Kingdom Electronic address
    Ophthalmology 121:1174-84. 2014
    To provide a detailed phenotype/genotype characterization of Bietti crystalline dystrophy (BCD).
  20. pmc Molecular analysis and phenotypic study in 14 Chinese families with Bietti crystalline dystrophy
    Houfa Yin
    Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, Zhejiang Province, China
    PLoS ONE 9:e94960. 2014
    To investigate the clinical features and cytochrome P450 family 4 subfamily V polypeptide 2 (CYP4V2) gene mutations in 14 Chinese families with Bietti crystalline dystrophy (BCD).
  21. pmc Cloning, sequencing, and expression of clustered genes encoding beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase, crotonase, and butyryl-CoA dehydrogenase from Clostridium acetobutylicum ATCC 824
    Z L Boynton
    Department of Biochemistry and Cell Biology, The Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77005 1892, USA
    J Bacteriol 178:3015-24. 1996
    The enzymes beta-hydroxybutyryl-coenzyme A (CoA) dehydrogenase (BHBD), crotonase, and butyryl-CoA dehydrogenase (BCD) from Clostridium acetobutylicum are responsible for the formation of butyryl-CoA from acetoacetyl-CoA...
  22. pmc Involvement of NADH:acceptor oxidoreductase and butyryl coenzyme A dehydrogenase in reversed electron transport during syntrophic butyrate oxidation by Syntrophomonas wolfei
    Nicolai Müller
    Fachbereich Biologie, Universitat Konstanz, Constance, Germany
    J Bacteriol 191:6167-77. 2009
    ..Furthermore, purification of butyryl-CoA dehydrogenase (Bcd) activity and peptide mass fingerprinting revealed two Bcd proteins different from the Bcd subunit of the Bcd/..
  23. ncbi Use of modified Lactobacillus selective medium and Bifidobacterium iodoacetate medium for differential enumeration of Lactobacillus acidophilus and Bifidobacterium spp. in powdered nutritional products
    S C Ingham
    University of Wisconsin Madison, Department of Food Science, 53706 1565, USA
    J Food Prot 62:77-80. 1999
    ..5 mg iodoacetic acid/liter; mBIM) was compared to MRS agar + bile, cysteine, and dicloxacillin (MRS + BCD) for enumerating Bifidobacterium infantis or Bifidobacterium lactis in the nutritional products...
  24. ncbi Expression of selected T-cell antigens in the skin infiltration in primary cutaneous T-cell lymphomas
    D Wojnowska
    Department of Dermatology, Medical University of Lublin
    Ann Univ Mariae Curie Sklodowska Med 56:237-42. 2001
    ..Cases of benign chronic skin disorders (BCD) were included in control group...
  25. ncbi High-performance liquid chromatography coupled to enzyme-amplified biochemical detection for the analysis of hemoglobin after pre-column biotinylation
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 886:19-29. 2000
    The determination of proteins with enzyme-amplified biochemical detection (EA-BCD) coupled on-line with high-performance liquid chromatography (HPLC) is demonstrated. The EA-BCD system was developed to detect biotin-containing compounds...
  26. ncbi Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata)
    Satoko Niimi
    Center for Marine Environmental Studies CMES, Ehime University, Bunkyo cho 2 5, Matsuyama 790 8577, Japan
    Comp Biochem Physiol B Biochem Mol Biol 147:667-81. 2007
    ..high identities with cattle CYP2C86 (83%), pig CYP2E1 (85%), sheep CYP3A24 (82%), pig CYP4A21 (80%), and human CYP4V2 (76%), respectively...
  27. ncbi Enzyme amplification as detection tool in continuous-flow systems. II. On-line coupling of liquid chromatography to enzyme-amplified biochemical detection after pre-column derivatization with biotin
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 855:397-409. 1999
    Enzyme-amplified biochemical detection (EA-BCD) was used as a post-column detection technique, coupled on-line with high-performance liquid chromatography (HPLC)...
  28. doi Inhibition of three selected beverage extracts on alpha-glucosidase and rapid identification of their active compounds using HPLC-DAD-MS/MS and biochemical detection
    De Qiang Li
    Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
    J Agric Food Chem 58:6608-13. 2010
    ..online liquid chromatography-diode array detection-tandem mass spectrometry and biochemical detection (LC-DAD-MS/MS-BCD) was developed to screen and identify alpha-glucosidase inhibitors from selected beverage extracts, including pu-..
  29. doi Influence of supplemental dietary poultry fat, phytase, and 25-hydroxycholecalciferol on the performance of commercial layers inoculated before or at the onset of lay with F-strain Mycoplasma gallisepticum
    S W Park
    Department of Poultry Science, Mississippi State University, Mississippi State 39762, USA
    Poult Sci 89:910-6. 2010
    ..were administered at 12 (before lay) and 22 (early in lay) wk and dietary treatments [basal control diet (BCD), BCD with 0.75% supplemental PF, BCD with 1.50% supplemental PF, and BCD with 1.50% supplemental PF, 0...
  30. ncbi Blood pressure in relation to biomarkers of lead, cadmium, copper, zinc, and selenium in men without occupational exposure to metals
    S Telisman
    Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Environ Res 87:57-68. 2001
    ..BPb), activity of delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), blood cadmium (BCd), serum copper (SCu), serum zinc (SZn), serum selenium (SSe), hematocrit (Hct), body mass index (BMI), age, smoking ..
  31. ncbi Binding of N-acetylglucosamine oligosaccharides to hen egg-white lysozyme: a powder diffraction study
    R B Von Dreele
    XPS IPNS Divisions, Argonne National Laboratory, Argonne, IL 60439, USA
    Acta Crystallogr D Biol Crystallogr 61:22-32. 2005
    ..The NAG2 ligand was found in the BC sites in the cleft of HEWL, NAG3 was found to bind in both the ABC and BCD sites in the ratio 35:65 and NAG4 and NAG5 bound to the ABCD and ABCDE sites, respectively, while NAG6 only bound ..
  32. ncbi Pathology of Hematodinium infections in snow crabs (Chionoecetes opilio) from Newfoundland, Canada
    Kersten Wheeler
    Virginia Institute of Marine Science, The College of William and Mary, School of Marine Science, Gloucester Point, VA 23062, USA
    J Invertebr Pathol 95:93-100. 2007
    Bitter crab disease (BCD) of snow crabs, Chionoecetes opilio, is caused by a parasitic dinoflagellate, Hematodinium sp...
  33. ncbi Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli
    Masayuki Inui
    Research Institute of Innovative Technology for the Earth, Kizugawa, Kyoto, Japan
    Appl Microbiol Biotechnol 77:1305-16. 2008
    A recombinant butanol pathway composed of Clostridium acetobutylicum ATCC 824 genes, thiL, hbd, crt, bcd-etfB-etfA, and adhe1 (or adhe) coding for acetyl-CoA acetyltransferase (THL), beta-hydroxybutyryl-CoA dehydrogenase (HBD), 3-..
  34. ncbi Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5
    Dzung H Nguyen
    Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Blood 99:4298-306. 2002
    ..We found that cholesterol extraction by hydroxypropyl-beta-cyclodextrin (BCD) significantly reduced the binding and signaling of macrophage inflammatory protein 1 beta (MIP-1 beta) using CCR5-..
  35. pmc Empty spiracles, a gap gene containing a homeobox involved in Drosophila head development
    U Walldorf
    Department of Cell Biology, University of Basel, Switzerland
    EMBO J 11:2247-59. 1992
    ..The early expression of the ems gene is controlled by the anterior morphogen bicoid (bcd). Using a gene fusion we identified a cis-acting element which is a target for the bcd gene product...
  36. doi Development of a liquid chromatography-based screening methodology for proteolytic enzyme activity
    Nils Helge Schebb
    Westfalische Wilhelms Universitat Munster, Institut fur Anorganische und Analytische Chemie, Corrensstrasse 30, 48149 Munster, Germany
    J Chromatogr A 1216:4407-15. 2009
    ..detection of the responsible enzymes by means of liquid chromatography hyphenated online to biochemical detection (BCD)...
  37. ncbi Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA
    M E Hinsdale
    Department of Comparative Medicine, School of Medicine, University of Alabama, Birmingham 35294 0019
    Genomics 16:605-11. 1993
    ..Both abnormal transcripts have aberrant stop codons. These results demonstrate the molecular basis of SCAD deficiency in this unique mouse model...
  38. pmc Rapid screening for depression--validation of the Brief Case-Find for Depression (BCD) in medical oncology and palliative care patients
    M Jefford
    Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Victoria 8006, Australia
    Br J Cancer 91:900-6. 2004
    ..Screening can increase case recognition. The Brief Case-Find for Depression (BCD) is a four-question, interviewer-administered instrument that has been previously validated in a general medical ..
  39. ncbi Characterization and transcription of the genes involved in butyrate production in Butyrivibrio fibrisolvens type I and II strains
    Narito Asanuma
    Department of Life Science, College of Agriculture, Meiji University, Higashimita, Tama ku, Kawasaki 214 8571, Japan
    Curr Microbiol 51:91-4. 2005
    ..from acetyl-CoA to butyryl-CoA, thl (thiolase), crt (crotonase), hbd (beta-hydroxybutyryl-CoA dehydrogenase), bcd (butyryl-CoA dehydrogenase), etfB (electron transfer flavoprotein [ETF]-beta), and etfA (ETF-alpha), were found to ..
  40. pmc Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population
    Tim S Nawrot
    Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Herestraat 49, Leuven, Belgium
    Environ Health Perspect 116:1620-8. 2008
    ..Few population studies have reported on the long-term changes in the internal cadmium dose and simultaneously occurring mortality...
  41. doi Reconstructing the clostridial n-butanol metabolic pathway in Lactobacillus brevis
    Oksana V Berezina
    State Research Institute of Genetics and Selection of Industrial Microorganisms, 1st Dorojniy pr 1, 117545, Moscow, Russian Federation
    Appl Microbiol Biotechnol 87:635-46. 2010
    ..The genes crt, bcd, etfB, etfA, and hbd, composing the bcs-operon, and the thl gene encode the enzymes of the lower part of the ..
  42. ncbi Epidemiology of bitter crab disease (Hematodinium sp.) in snow crabs Chionoecetes opilio from Newfoundland, Canada
    Jeffrey D Shields
    Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062, USA
    Dis Aquat Organ 64:253-64. 2005
    The parasitic dinoflagellate Hematodinium sp. causes a condition known as bitter crab disease (BCD) in snow crabs Chionoecetes opilio and Tanner crabs C. bairdi...
  43. ncbi Epidemiological determinants in outbreaks of bitter crab disease (Hematodinium sp.) in snow crabs Chionoecetes opilio from Conception Bay, Newfoundland, Canada
    Jeffrey D Shields
    Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062, USA
    Dis Aquat Organ 77:61-72. 2007
    Bitter crab disease (BCD) is caused by Hematodinium sp., an endoparasitic dinoflagellate. It lives within the hemocoeloms of snow crabs Chionoecetes opilio and Tanner crabs C. bairdi, making them unmarketable due to their bitter flavor...
  44. pmc Target selectivity of bicoid is dependent on nonconsensus site recognition and protein-protein interaction
    C Zhao
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 20:8112-23. 2000
    We describe experiments to compare the activities of two Drosophila homeodomain proteins, Bicoid (Bcd) and an altered-specificity mutant of Fushi tarazu, Ftz(Q50K)...
  45. ncbi Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms
    Luiz Paulo Moura Andrioli
    Department of Biology, New York University, 1009 Main Building, 100 Washington Square East, New York 10003 6688, USA
    Development 129:4931-40. 2002
    ..The enhancer for eve stripe 2 (eve 2) is directly activated by the morphogens Bicoid (Bcd) and Hunchback (Hb)...
  46. ncbi A comparison of bicarbonate hemodialysis, hemodiafiltration, and acetate-free biofiltration on cytokine production
    Terumi Higuchi
    Department of Medicine, Division of Nephrology and Endocrinology, Nihon University School of Medicine, Tokyo 170 0032, Japan
    Ther Apher Dial 8:460-7. 2004
    ..of this study was to investigate the difference of cytokine production by conventional bicarbonate hemodialysis (BCD), standard HDF and AFB in the same patients...
  47. ncbi Localized maternal orthodenticle patterns anterior and posterior in the long germ wasp Nasonia
    Jeremy A Lynch
    Center for Developmental Genetics, NYU Biology, 100 Washington Square East New York, New York 10003, USA
    Nature 439:728-32. 2006
    The Bicoid (Bcd) gradient in Drosophila has long been a model for the action of a morphogen in establishing embryonic polarity. However, it is now clear that bcd is a unique feature of higher Diptera...
  48. ncbi Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma
    S A Kaliberov
    Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Gene Ther 14:1111-9. 2007
    ..We have developed an Ad vector encoding a mutant bacterial cytosine deaminase (bCD) gene (AdbCD-D314A), which has a higher affinity for cytosine than wild-type bCD (bCDwt)...
  49. ncbi Characterization of a cyclodextrinoligonucleotide complex by capillary electrophoresis using laser-induced fluorescence
    Jeffrey W Guthrie
    Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry and School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Pharm Pharm Sci 10:246-55. 2007
    ....
  50. ncbi The PucC protein of Rhodobacter capsulatus mitigates an inhibitory effect of light-harvesting 2 alpha and beta proteins on light-harvesting complex 1
    Paul R Jaschke
    Department of Microbiology and Immunology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
    Photosynth Res 95:279-84. 2008
    ..genes, and homologues in other photosynthetic organisms, have been classified as the bacteriochlorophyll delivery (BCD) family of the major facilitator superfamily...
  51. doi DNA ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions
    Xiaoqi Zhang
    Departments of Medicine, Veterans Affairs Boston Healthcare System, Harvard Medical School, West Roxbury, MA 02132, USA
    Am J Surg Pathol 32:1327-35. 2008
    ..01) from nondysplastic BE to basal crypt dysplasia (BCD), low-grade dysplasia (LGD), high-grade dysplasia (HGD), and adenocarcinoma (AC)...
  52. doi Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene
    Lyudmila N Kaliberova
    Department of Radiation Oncology, University of Alabama at Birmingham, 1530 3rd Avenue South, WTI 674, Birmingham, AL 35294 6832, USA
    Mol Cancer Ther 7:2845-54. 2008
    ..We have developed an adenoviral vector (AdbCD-D314A) encoding a mutant bacterial cytosine deaminase (bCD) gene, which converts the prodrug 5-fluorocytosine (5-FC) into the active drug 5-fluorouracil...
  53. pmc Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo
    Michi Fuchita
    School of Molecular Biosciences and Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164 6534, USA
    Cancer Res 69:4791-9. 2009
    ..we reported individual point mutations within the substrate binding pocket of bacterial cytosine deaminase (bCD) that result in marginal improvements in the ability to sensitize cells to 5-fluorocytosine (5FC)...
  54. ncbi Bridge to dentistry: one dental school's approach to improving its enrollment of underrepresented minorities
    Ernestine S Brooks
    Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, TX, USA
    J Am Coll Dent 69:23-30. 2002
    ..53%. This trend is evident at Baylor College of Dentistry (BCD)...
  55. pmc Bicoid functions without its TATA-binding protein-associated factor interaction domains
    V Schaeffer
    Howard Hughes Medical Institute, The Rockefeller University, Box 151, New York, NY 10021 6399, USA
    Proc Natl Acad Sci U S A 96:4461-6. 1999
    ..The key component of the anterior system is the homeodomain protein Bicoid (Bcd)...
  56. pmc Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model
    Florian Graepler
    Department of Internal Medicine I, Medical University Clinic Tubingen, Germany
    World J Gastroenterol 11:6910-9. 2005
    ..To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model...
  57. ncbi [Stricture recanalisation of the distal urether with various endoprothesis]
    A Mladenovic
    Centar za radiologiju, Odeljenje KCS, Beograd
    Acta Chir Iugosl 57:61-4. 2010
    ..of continous development of the new generation methods percutaneous nephrostomy (PCN), ballon catheter dilatation (BCD), methal and covered stent application...
  58. ncbi Enzyme amplification as detection tool in continuous-flow systems. I. Development of an enzyme-amplified biochemical detection system coupled on-line to flow-injection analysis
    M R van Bommel
    Division of Analytical Chemistry, Leiden/Amsterdam Center of Drug Research, Leiden University, The Netherlands
    J Chromatogr A 855:383-96. 1999
    The on-line coupling of flow-injection analysis (FIA) to an enzyme-amplified biochemical detection (EA-BCD) system is described...
  59. pmc The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features
    Henning Seedorf
    Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 105:2128-33. 2008
    ..energy-converting NADH:ferredoxin oxidoreductase (RnfCDGEAB) and a cytoplasmic butyryl-CoA dehydrogenase complex (Bcd/EtfAB) coupling the reduction of crotonyl-CoA to butyryl-CoA with the reduction of ferredoxin represent a new ..
  60. pmc Blood and urine cadmium, blood pressure, and hypertension: a systematic review and meta-analysis
    Carolyn M Gallagher
    Doctoral Program in Population Health and Clinical Outcomes Research, Stony Brook University Medical Center, Stony Brook, New York, USA
    Environ Health Perspect 118:1676-84. 2010
    ..Cadmium exposure has been inconsistently related to blood pressure...
  61. ncbi Blepharo-cheilo-dontic (BCD) syndrome: case report
    Akihiko Iida
    Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Cleft Palate Craniofac J 43:237-43. 2006
    To report a case of blepharo-cheilo-dontic (BCD) syndrome, to compare with the previous cases, and to discuss the possible treatment.
  62. doi Imperforate anus is a rare associated finding in blepharocheilodontic syndrome
    K Nicole Weaver
    University of Alabama School of Medicine, Birmingham, Alabama, USA
    Am J Med Genet A 152:438-40. 2010
    Blepharocheilodontic (BCD) syndrome is a rare autosomal-dominant condition that is characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and conical teeth...
  63. pmc Nanoplex delivery of siRNA and prodrug enzyme for multimodality image-guided molecular pathway targeted cancer therapy
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States
    ACS Nano 4:6707-16. 2010
    ..up-regulated in aggressive breast cancer cells, was combined with the prodrug enzyme bacterial cytosine deaminase (bCD) that converts the nontoxic prodrug 5-fluorocytosine (5-FC) to cytotoxic 5-fluorouracil (5-FU)...
  64. ncbi Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte
    D St Johnston
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    Development 107:13-9. 1989
    The anterior region of the Drosophila embryonic pattern is determined by a gradient of the bicoid (bcd) protein. The correct formation of this gradient requires the localization of bcd RNA to the anterior pole of the egg...
  65. pmc Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription
    Dechen Fu
    Graduate Program in Molecular and Developmental Biology, Division of Developmental Biology, Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 23:4439-48. 2003
    Bicoid (Bcd) is a Drosophila melanogaster morphogenetic gradient that controls embryonic patterning by activating target gene expression in a concentration-dependent manner...
  66. ncbi Identification of a new C28H14 polycyclic aromatic hydrocarbon as a product of supercritical fuel pyrolysis: Tribenzo[cd,ghi,lm]perylene
    Jennifer W McClaine
    Department of Chemical Engineering, Louisiana State University, South Stadium Drive, Baton Rouge, LA 70803, USA
    J Chromatogr A 1138:175-83. 2007
    ..phenanthro[5,4,3,2-efghi]perylene, benzo[cd]naphtho[3,2,1,8-pqra]perylene, and benzo[pqr]naphtho[8,1,2-bcd]perylene--have already been identified as supercritical pyrolysis products by matching their UV spectra with those ..
  67. ncbi Organic substrate quality as the link between bacterioplankton carbon demand and growth efficiency in a temperate salt-marsh estuary
    Jude K Apple
    Horn Point Laboratory, University of Maryland Center for Environmental Science, Cambridge, MD, USA
    ISME J 1:729-42. 2007
    ..Studies of bacterioplankton carbon demand (BCD) and growth efficiency (BGE) frequently report higher values in more productive systems, suggesting these aspects ..
  68. pmc Spatial bistability generates hunchback expression sharpness in the Drosophila embryo
    Francisco J P Lopes
    Department of Applied Mathematics, Stony Brook University, Stony Brook, New York, United States of America
    PLoS Comput Biol 4:e1000184. 2008
    ..the hunchback (hb) gene at midembryo, in response to local concentrations of the smooth anterior-posterior Bicoid (Bcd) gradient...
  69. doi Effects of cadmium on forearm bone density after reduction of exposure for 10 years in a Chinese population
    Xiao Chen
    Institute of Radiation Medicine, Fudan University, 200032, Shanghai, China
    Environ Int 35:1164-8. 2009
    ..Samples of urine and blood were collected for determination of cadmium in urine (UCd) and blood (BCd)...
  70. doi Enhanced immune response to pneumococcal infection in malnourished mice nasally treated with heat-killed Lactobacillus casei
    Julio Villena
    Reference Center for Lactobacilli CERELA CONICET, Tucuman, Argentina
    Microbiol Immunol 53:636-46. 2009
    ..Weaned mice were malnourished after consuming a PFD for 21 days. Malnourished mice were fed a BCD for 7 days or BCD for 7 days with viable or non-viable L...
  71. ncbi Spectral OCT analysis in Bietti crystalline dystrophy
    David Gaucher
    Service d Ophtalmologie du Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, Strasbourg Cedex France
    Eur J Ophthalmol 20:612-4. 2010
    To report the analysis of the cornea and the macular retina using both time domain (TD-OCT) and Fourier domain optical coherence tomography (FD-OCT) in a case of Bietti crystalline dystrophy (BCD).
  72. doi Fracture of bony lamellae within the frontal recess after balloon catheter dilatation
    Ayesha N Khalid
    Division of Rhinology, Department of Otolaryngology Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Am J Rhinol Allergy 24:55-9. 2010
    The precise manner in which balloon catheter dilatation (BCD) alters the dimensions of the frontal recess and frontal sinus outflow tract is not well characterized...
  73. ncbi The eve stripe 2 enhancer employs multiple modes of transcriptional synergy
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    Development 122:205-14. 1996
    ..The bicoid (bcd) regulatory gradient triggers the expression of hunchback (hb); these work synergistically to activate the stripe ..
  74. ncbi Neither the homeodomain nor the activation domain of Bicoid is specifically required for its down-regulation by the Torso receptor tyrosine kinase cascade
    Y Bellaiche
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Development 122:3499-508. 1996
    Bicoid (Bcd) is a maternal morphogen responsible for patterning the head and thorax of the Drosophila embryo...
  75. pmc Inhibition of expression of P-selectin by antioxidant in cholesterol-fed rats
    C S Lee
    Department of Pathology, Chungnam National University College of Medicine, Taejon, Korea
    J Korean Med Sci 14:8-14. 1999
    ..5% cholesterol and 0.1% sodium cholate (CD), or the CD diet containing 0.5% BHT (BCD). Rats were sacrificed after 3 days, and after 1, 2, 4, 10, and 17 weeks of dietary treatment...
  76. ncbi Blepharo-cheilo-dontic (BCD) syndrome in two Mexican patients
    M H Valdéz-de la Torre
    Departamento de Genetica, Hospital General Dr Manuel Gea Gonzalez, Mexico City, Mexico
    Am J Med Genet 85:157-9. 1999
    ..eyelids, distichiasis, euryblepharon, cleft lip/palate, and oligodontia was recently named blepharo-cheilo-dontic (BCD) syndrome. Different combinations of these signs have been found sporadically, with autosomal dominant inheritance...
  77. ncbi Lead effect on blood pressure in moderately lead-exposed male workers
    Spomenka Telisman
    Department of Occupational and Environmental Health, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    Am J Ind Med 45:446-54. 2004
    ..The effect of lead (Pb) and potential confounding variables on blood pressure was examined in healthy male industrial workers 20-43 years of age...
  78. ncbi The co-activator CREB-binding protein participates in enhancer-dependent activities of bicoid
    Dechen Fu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 279:48725-33. 2004
    Bicoid (Bcd) is a transcriptional activator required for early embryonic patterning in Drosophila...
  79. pmc Maternal expression relaxes constraint on innovation of the anterior determinant, bicoid
    Michael S Barker
    Department of Biology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Genet 1:e57. 2005
    ..patterning during embryogenesis is a major developmental innovation and the rapidly evolving Hox gene, bicoid (bcd), plays a critical role...
  80. ncbi The endogenous immune response modulates the course of IgA-immune complex mediated nephropathy
    T K Chao
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Kidney Int 70:283-97. 2006
    ..play, we have developed a passive model with exclusive IgA-immune complex-mediated nephropathy in B-cell-deficient (BCD) mice...
  81. pmc Expression and regulation of caudal in the lower cyclorrhaphan fly Megaselia
    Michael Stauber
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Am Fassberg 11, 37077, Gottingen, Germany
    Dev Genes Evol 218:81-7. 2008
    ..The CAD gradient is complementary to and dependent on the anterior pattern organizer Bicoid (BCD), which represses the translation of ubiquitous maternal cad transcripts in the anterior embryo through a direct ..
  82. doi Urceolatin, a structurally unique bromophenol from Polysiphonia urceolata
    Ke Li
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, PR China
    Org Lett 10:1429-32. 2008
    6-Bromo-1-(3-bromo-4,5-dihydroxybenzyl)phenanthro[4,5-bcd]furan-2,3,5-triol (urceolatin, 1), a highly oxygenated bromophenol containing an unprecedented naturally occurring benzylphenanthro[4,5-bcd]furan unit, was isolated from the ..
  83. doi Novel CYP4V2 gene mutation in a Mexican patient with Bietti's crystalline corneoretinal dystrophy
    Juan C Zenteno
    Department of Genetics and Research Unit, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico
    Curr Eye Res 33:313-8. 2008
    ..To report the clinical and genetic analysis of a Mexican female patient with a sporadic Bietti's crystalline corneoretinal dystrophy...
  84. doi Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy
    Cong Li
    JHU ICMIC Program, The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Med Chem 51:3572-82. 2008
    We previously observed that bacterial cytosine deaminase (bCD) conjugated with multimodal imaging reporter labeled poly-L-lysine (PLL) demonstrated high therapeutic efficacy in an enzyme/prodrug cancer therapeutic strategy...
  85. ncbi [Construction of HBD-3 gene mammary-specific expression vector and eukaryotic expression]
    Wei Peng
    Institute of Biotechnology, College of Animal Veterinary Medicine, Northwest Agiculture and Forestry University, Yangling 712100, China
    Sheng Wu Gong Cheng Xue Bao 25:968-74. 2009
    ..Then we moved the combined fragment BCD (including 5' and 3' regulating region of beta-casein and hBD) into the corresponding site of the plasmid pEGFP-C1...
  86. doi Structure and binding of peptide-dendrimer ligands to vitamin B12
    Nicolas A Uhlich
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 11:358-65. 2010
    ..Substituting glutamates (E) for glutamines (Q) in the outer branches of B1 to form N3 (AcQS)8(BQA)4(B-Amb-Y)(2)BCD-NH2 leads to stronger (K(a)=12.0 x 10(6) M(-1)) but slower (k(2)=67 M(-1) s(-1)) cobalamin binding...
  87. doi A novel, versatile D-->BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone
    Vincent Foucher
    University of Southampton, School of Chemistry, Highfield, Southampton SO17 1BJ, United Kingdom
    Org Lett 12:680-3. 2010
    ..The method is illustrated by the total synthesis of estrone via a C-ring closing metathesis and a B-ring Heck cyclization...
  88. pmc MAPK substrate competition integrates patterning signals in the Drosophila embryo
    Yoosik Kim
    Department of Chemical Engineering and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 20:446-51. 2010
    ..We establish that downregulation of Cic is antagonized by the anterior patterning morphogen Bicoid (Bcd)...
  89. doi Air-handling capabilities of blood cardioplegia delivery systems in a simulated pediatric model
    David Palanzo
    Heart and Vascular Institute, Penn State Hershey College of Medicine, Penn State Hershey Children s Hospital Hershey, PA 17033 0850, USA
    Artif Organs 34:950-4. 2010
    ..following cardioplegia delivery systems: GISH Vision, Maquet Plegiox, Medtronic Trillium MYOtherm XP, Sorin Group BCD Vanguard, Sorin Group CSC14, and Terumo Sarns Conducer and Bubble Trap. The 0.25-in...
  90. pmc Assignment and stereocontrol of hibarimicin atropoisomers
    Ian M Romaine
    Department of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Org Lett 13:4538-41. 2011
    ..From these atropoenantiomers the BCD-EFG ring system of HMP-Y6 is constructed [(+)-aR-7]...
  91. pmc A Novel Compound Heterozygous Mutation in the CYP4V2 Gene in a Japanese Patient with Bietti's Crystalline Corneoretinal Dystrophy
    Yumiko Yokoi
    Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    Case Report Ophthalmol 2:296-301. 2011
    ..Methods: Using direct sequencing, mutation screening was performed in the CYP4V2 gene of both the patient with BCD and her daughter...
  92. ncbi Contribution of monaural and binaural cues to sound localization in listeners with acquired unilateral conductive hearing loss: improved directional hearing with a bone-conduction device
    Martijn J H Agterberg
    Department of Biophysics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Hear Res 286:9-18. 2012
    ..These conditions were tested while a bone-conduction device (BCD), fitted to all UCHL listeners in order to provide hearing from the impaired side, was turned off...
  93. doi Evidence-based practice: balloon catheter dilation in rhinology
    Pete S Batra
    Department of Otolaryngology Head and Neck Surgery, Comprehensive Skull Base Program, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Otolaryngol Clin North Am 45:993-1004. 2012
    Balloon catheter dilation (BCD) is a treatment paradigm for surgical management of paranasal sinus inflammatory disease. There are few robust clinical trials evaluating the efficacy of balloon technology in chronic rhinosinusitis (CRS)...
  94. pmc Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis
    Tiago Rafael Veloso
    Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
    Infect Immun 81:697-703. 2013
    ..lactis strain expressing an individual S. aureus surface protein (ClfA, FnbpA, BCD, or SdrE) conferring a particular adhesive or platelet aggregation property...
  95. doi Balance and randomness in sequential clinical trials: the dominant biased coin design
    Alessandro Baldi Antognini
    Department of Statistical Sciences, University of Bologna, Via Belle Arti 41, Bologna, Italy
    Pharm Stat 13:119-27. 2014
    Efron's biased coin design (BCD) is a well-known randomization technique that helps neutralize selection bias, while keeping the experiment fairly balanced for every sample size...
  96. doi [First audiological results of the concha-worn bone conduction instrument C.A.I. BC811]
    T Giere
    Klinik fur Hals, Nasen und Ohrenheilkunde, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    HNO 63:50-5. 2015
    Diverse forms of bone conduction devices (BCD; percutaneous or transcutaneous) provide successful and well-established therapies for conductional hearing loss (CHL)...
  97. pmc Redifferentiation of adult human β cells expanded in vitro by inhibition of the WNT pathway
    Ayelet Lenz
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 9:e112914. 2014
    ..Using a lineage tracing approach we have demonstrated that β-cell-derived (BCD) cells rapidly dedifferentiate in culture and can proliferate for up to 16 population doublings...
  98. pmc Regulation of the formin Cappuccino is critical for polarity of Drosophila oocytes
    Batbileg Bor
    Molecular Biology Interdepartmental PhD Program, University of California, Los Angeles, California, 90095 1570
    Cytoskeleton (Hoboken) 72:1-15. 2015
    ..organization and cytoplasmic streaming are crucial for localization of polarity determinants such as osk, grk, bcd, and nanos mRNAs. Capu mutants disrupt these events, leading to female sterility...
  99. doi Reduction of ferredoxin or oxygen by flavin-based electron bifurcation in Megasphaera elsdenii
    Nilanjan P Chowdhury
    Laboratorium für Mikrobiologie, Fachbereich Biologie and SYNMIKRO, Philipps Universitat, Marburg, Germany
    FEBS J 282:3149-60. 2015
    ..bifurcation in which the exergonic reduction of crotonyl-CoA by NADH mediated by Etf + butyryl-CoA dehydrogenase (Bcd) was coupled to the endergonic reduction of ferredoxin also by NADH...
  100. doi Low oxygen tension reveals distinct HOX codes in human cord blood-derived stromal cells associated with specific endochondral ossification capacities in vitro and in vivo
    Stefanie Liedtke
    Institute of Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University Medical Centre, Dusseldorf, Germany
    J Tissue Eng Regen Med . 2016
    ..CB-MSCsABCD ); and subpopulations missing a single cluster (CB-MSCsACD and CB-MSCsBCD )...
  101. pmc Comparative analysis of protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle and nanoliposomal curcumin on unsymmetrical dimethyl hydrazine poisoning in mice
    Wei Li
    a Hubei Cooperative Innovation Center for Industrial Fermentation, Research Center of Food Fermentation Engineering and Technology of Hubei, Hubei University of Technology, Wuhan, PR China
    Bioengineered 7:334-341. 2016
    ..of this study was to compare the protective effects of curcumin, curcumin-β-cyclodextrin nanoparticle curcumin (BCD-CUR) and nanoliposomal curcumin (NLC) on unsymmetrical dimethylhydrazine (UDMH) induced poison in mice...

Research Grants42

  1. Stephen J Small; Fiscal Year: 2016
    ..These enhancers all contain clusters of binding sites for a single transcription factor, Bicoid (Bcd), which is expressed in a long-range gradient in the very early embryo...
  2. Translational repressors in Drosophila development
    Robin P Wharton; Fiscal Year: 2013
    ..Our experiments suggest that the NRE may mediate regulation of bcd mRNA during post- embryonic development, a hypothesis that will be tested in this proposal...
  3. Engineering enzymes for anti-tumor suicide gene therapy
    Barry L Stoddard; Fiscal Year: 2010
    ..a set of revised specific aims for this project as follows: (1) We will determine whether optimization of yCD or bCD leads to significant therapeutic efficacy gains via recognizable mechanisms of increased enzyme expression and/or ..
  4. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of ..
  5. In Vivo Evaluation of Presbyopia
    Kathryn Richdale; Fiscal Year: 2013
    The goals of this BCD award are to: 1) train Kathryn Richdale, OD MS as an interdisciplinary clinician- scientist and 2) further elucidate the structural and mechanical changes associated with presbyopia...
  6. Dual Action Inhibitors of Gyrase Beta and Histidine Kinases as Broad-Spectrum Ant
    Peter B Madrid; Fiscal Year: 2010
    ..potential structural similarities of the adenine-binding pockets of these proteins, we hypothesize that a 0)_ BCD [unreadable]-o 0)+, 0>-0 (<D ?cam p.' E; T-- <.-n[unreadable] _0:N O'[unreadable] >.Q -a...
  7. Jun Ma; Fiscal Year: 2015
    ..The Drosophila morphogen gradient of Bicoid (Bcd) instructs anterior- posterior (AP) patterning by directly activating its downstream target genes in a ..
  8. Baylor's Scientific Training Program for Dental Academic Researchers: B-STARS
    RENA N D'SOUZA; Fiscal Year: 2012
    ..B-STARS draw from the expanding scientific, intellectual and physical resources at Baylor College of Dentistry (BCD)...
  9. Baylor's Program for Bioengineering Sciences and Translational Research "B-BEST"
    RENA N D apos SOUZA; Fiscal Year: 2010
    ..Their skills will complement and add to existing strengths of BCD's Department of Biomedical Sciences (BMS), whose faculty engage in clinically-relevant, translational research ..
  10. Mechanisms of Response and Relapse in Rituximab-treated Myositis Patients
    Chester V Oddis; Fiscal Year: 2013
    ..One of the more novel treatments for myositis as well as other autoimmune diseases is B cell depletion (BCD) therapy with a biologic agent, rituximab...
  11. Leica SP5 Confocal Microscope
    KATHY KAY SVOBODA; Fiscal Year: 2010
    ..funds for a Leica TCS SP5 MP Fixed stage (UV- VIS-IR) confocal microscope for the Baylor College of Dentistry (BCD) light microscopy core facility...
  12. MOLECULAR BIOLOGY OF MORPHOGEN LOCALIZATION IN EMBRYOS
    Paul MacDonald; Fiscal Year: 2006
    ..The example studied here, localization of bicoid (bcd) mRNA in the Drosophila oocyte and embryo, is essential for embryonic body patterning...
  13. Improved Suicide Gene Therapy for Hepatic Cancers
    William Ensminger; Fiscal Year: 2005
    ..compared to the previously utilized bacterial (b) CD (Aim 1) and, thus will work at FC levels lower than the bCD in gut bacteria (for lowered systemic toxicity)...
  14. Translating Dental Student Tobacco Education to Practice
    KATHLEEN RANKIN; Fiscal Year: 2007
    ..and integrated into appropriate courses throughout the 4-year dental curriculum at Baylor College of Dentistry (BCD). Full integration of the Rx for Change core curriculum will occur over a period of 3 years...
  15. Individual Predoctoral Dental Scientist Fellowship
    Hoa Nguyen; Fiscal Year: 2009
    ..proposes a graduate educational program at Baylor College of Dentistry, Texas A&M University System (BCD) for Mr. Hoa Nguyen...
  16. DENDRITIC CELLS & ACTINOBACILLUS ACTINOMYCETEMCOMITANS
    Paul Ezzo; Fiscal Year: 2004
    ..The research environment established at Baylor College of Dentistry (BCD) by Dr. Christopher Cutler, in collaboration with Dr...
  17. SCREENING QUALITY OF CARE USING ADMINISTRATIVE DATA
    Lisa Iezzoni; Fiscal Year: 1991
    ..for patients' a priori risks of poor outcomes and complications related to the burden of chronic disease (BCD)...
  18. Individual Predoctoral Dental Scientist Fellowship
    ERIC HARRINGTON; Fiscal Year: 2005
    ..proposes a five year educational program at Baylor College of Dentistry, Texas A and M University System (BCD) for Mr. David Erik Kern. This program will combine Ph.D...
  19. EDENTULATION AND MECHANICS OF THE CRANIOFACIAL SKELETON
    Jill Peterson; Fiscal Year: 2001
    ..proposes a five year educational program at Baylor College of Dentistry, Texas A and M University System (BCD) for Dr. Jill Peterson. This program will combine Ph.D...
  20. Research Infrastructure Improvement Planning Award
    David Carlson; Fiscal Year: 2003
    ..a formal strategic planning process for improvement of the research infrastructure at Baylor College of Dentistry (BCD)...
  21. Dynamics, scaling, and precision of morphogen gradients in the Drosophila embryo
    William Bialek; Fiscal Year: 2009
    ..dynamics of the formation and stabilization of the Bed gradient will be measured in living embryos expressing eGFP-Bcd. Image sequences from time-lapse two photon microscopy will be used, together with photobleaching methods and ..
  22. Individual Predoctoral Dental Scientist Fellowship
    JOSEPH RAWLINS; Fiscal Year: 2006
    ..provided by applicant): This application proposes a graduate educational program at Baylor College of Dentistry (BCD), Texas A&M University System for Mr. Joseph T. Rawlins...
  23. BCD Research Infrastructure Enhancement Program
    David Carlson; Fiscal Year: 2005
    ..the Infrastructure Improvement Grant is to strengthen the research infrastructure of Baylor College of Dentistry (BCD) by recruiting and developing outstanding faculty in tenure track positions and by developing the core ..
  24. Bioassays Capable of Detecting Single Molecules
    STEVEN OLDENBURG; Fiscal Year: 2002
    ..Additional products will be developed for the detection of low levels of toxic agents (BCD), monitoring environmental contaminants, and measurement of illegal drug levels...
  25. METHODOLOGY FOR THE SYNTHESIS OF NITROGEN HETEROCYCLES
    Philip Magnus; Fiscal Year: 2007
    ..The synthetic intermediates, particularly as they more closely resemble the natural products, will be screened to assess biological activity. [unreadable] [unreadable]..
  26. Child & Family Disaster Research Training & Education
    Betty Pfefferbaum; Fiscal Year: 2008
    ..6) To design a modular, multidisciplinary research-training curriculum on child and family disaster mental health incorporating modern principles of public mental health and a scientifically informed developmental psychopathology model. ..
  27. The Development of An Eating Laboratory for Overweight Adolescents
    B Walsh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. PSYCHOBIOLOGY OF EATING BEHAVIOR IN EATING DISORDERS
    B Walsh; Fiscal Year: 2008
    ..Additional experiments will examine whether excitatory controls of eating, as reflected by sham feeding (i.e., consumption of non-caloric food) and by cue reactivity, are increased in patients with BN and BED. ..
  29. IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS
    RAFAEL BOWEN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  30. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  31. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  32. Translational Research on Eating Disorders
    B Walsh; Fiscal Year: 2006
    ....
  33. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..
  34. Mini spindles and microtubule function in Drosophila
    NANCY POKRYWKA; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  35. FLUOXETINE AFTER WEIGHT RESTORATION IN ANOREXIA NERVOSA
    B Walsh; Fiscal Year: 2004
    ..Outcome will be assessed on the basis of maintenance of weight and reduction in psychopathological symptoms characteristic of AN. ..
  36. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  37. SYNTHESIS OF DIAZONAMIDES
    Philip Magnus; Fiscal Year: 2004
    ..Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides. ..
  38. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  39. Synthesis of Tumor Inhibitory Marine Natural Products
    James Marshall; Fiscal Year: 2004
    ..The main chemical issues to be addressed include the control of stereochemistry by means of chiral organometal chemistry and the design of new and efficient routes to structurally novel natural products. ..
  40. Mechanisms of Swallow protein function in Drosophila
    NANCY POKRYWKA; Fiscal Year: 2002
    ....
  41. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  42. SYNTHESIS OF ANNONACEOUS ACETOGENINS AND ANALOGUES
    James Marshall; Fiscal Year: 2001
    ..The synthetic approach will employ chiral allylic and allenic organometal reagents to introduce stereogenic centers with concurrent formation of carbon-carbon bonds. ..