CYP27B1

Summary

Gene Symbol: CYP27B1
Description: cytochrome P450 family 27 subfamily B member 1
Alias: CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR, 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, 1alpha(OH)ase, 25 hydroxyvitamin D3-1-alpha hydroxylase, 25-OHD-1 alpha-hydroxylase, VD3 1A hydroxylase, calcidiol 1-monooxygenase, cytochrome P450 subfamily XXVIIB polypeptide 1, cytochrome P450, family 27, subfamily B, polypeptide 1, cytochrome P450C1 alpha, cytochrome P450VD1-alpha, cytochrome p450 27B1
Species: human

Top Publications

  1. ncbi Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain
    Darryl W Eyles
    Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    J Chem Neuroanat 29:21-30. 2005
  2. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
  3. pmc Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase
    Shuo Geng
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Bone Miner Res 26:1145-53. 2011
  4. doi PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients
    M Fichna
    Institute of Human Genetics, Polish Academy of Sciences, Przybyszewskiego 49, Poznan, Poland
    Int J Immunogenet 37:367-72. 2010
  5. ncbi Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
  6. doi A novel G102E mutation of CYP27B1 in a large family with vitamin D-dependent rickets type 1
    Ali S Alzahrani
    Departments of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 95:4176-83. 2010
  7. ncbi 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
  8. pmc The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Am J Pathol 161:105-14. 2002
  9. ncbi Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol
    Britta Diesel
    Institut fur Humangenetik, Theoretische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Cancer Res 11:5370-80. 2005
  10. ncbi HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase
    F Besancon
    INSERM Unité 417, Hopital Saint Antoine, Paris, France
    J Interferon Cytokine Res 17:461-7. 1997

Research Grants

  1. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
  2. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
  3. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Candace S Johnson; Fiscal Year: 2012
  4. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2010
  5. John M Brehm; Fiscal Year: 2015
  6. Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug Discovery
    John Norris; Fiscal Year: 2009
  7. Diet by Gene Interactions Affecting Calcium and Bone Metabolism
    James C Fleet; Fiscal Year: 2010
  8. Bandana Chatterjee; Fiscal Year: 2016
  9. Peter W Jurutka; Fiscal Year: 2014
  10. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010

Detail Information

Publications327 found, 100 shown here

  1. ncbi Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain
    Darryl W Eyles
    Queensland Centre for Schizophrenia Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    J Chem Neuroanat 29:21-30. 2005
    ..This paper reports, for the first time, the distribution of the 1,25-dihydroxyvitamin D3 receptor (VDR), and 1alpha-hydroxylase (1alpha-OHase), the enzyme responsible for the formation of the active vitamin in the ..
  2. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    ....
  3. pmc Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase
    Shuo Geng
    Department of Orthopedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Bone Miner Res 26:1145-53. 2011
    ..Recent evidence shows that hMSCs participate in vitamin D metabolism and can activate 25(OH)D(3) by CYP27B1/1α-hydroxylase...
  4. doi PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients
    M Fichna
    Institute of Human Genetics, Polish Academy of Sciences, Przybyszewskiego 49, Poznan, Poland
    Int J Immunogenet 37:367-72. 2010
    ..This study was aimed to investigate the association of PTPN22 G(-1123)C and C1858T, PDCD1 G7146A and CYP27B1 C(-1260)A polymorphisms with T1DM among Polish subjects...
  5. ncbi Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
    ..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate...
  6. doi A novel G102E mutation of CYP27B1 in a large family with vitamin D-dependent rickets type 1
    Ali S Alzahrani
    Departments of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 95:4176-83. 2010
    Mutations in the CYP27B1 gene, which encodes vitamin D 1alpha-hydroxylase, are the genetic basis for vitamin D-dependent rickets type 1 (VDDR-I).
  7. ncbi 25-hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    J Clin Endocrinol Metab 87:2967-72. 2002
    ..The findings imply that in addition to feedback control by circulating 1,25(OH)(2)D(3) levels, parathyroid cells may also be influenced by local 1alpha -hydroxylase activity with possible growth regulatory and differentiating effects...
  8. pmc The ontogeny of 25-hydroxyvitamin D(3) 1alpha-hydroxylase expression in human placenta and decidua
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    Am J Pathol 161:105-14. 2002
    ..These spatiotemporal data emphasize the potential importance of 1alpha-OHase during early fetoplacental life and, in particular, suggest an autocrine/paracrine immunomodulatory function for the enzyme...
  9. ncbi Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol
    Britta Diesel
    Institut fur Humangenetik, Theoretische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Cancer Res 11:5370-80. 2005
    ..A better understanding of the vitamin D(3) metabolism is required to evaluate its potential therapeutic value for cancers. Here, we set out to contribute to the understanding of vitamin D(3) metabolism in glioblastoma multiforme...
  10. ncbi HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase
    F Besancon
    INSERM Unité 417, Hopital Saint Antoine, Paris, France
    J Interferon Cytokine Res 17:461-7. 1997
    ....
  11. ncbi Expression and activity of 25-hydroxyvitamin D-1 alpha-hydroxylase are restricted in cultures of human syncytiotrophoblast cells from preeclamptic pregnancies
    Lorenza Díaz
    Department of Reproductive Biology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico Distrito Federal, 14000, Mexico
    J Clin Endocrinol Metab 87:3876-82. 2002
    ..These results support the role of placenta as a contributor to the abnormalities observed in calcium metabolism in PE...
  12. ncbi Gender-specific association of vitamin D receptor polymorphism combinations with type 1 diabetes mellitus
    Balazs Gyorffy
    First Department of Paediatrics, Semmelweis University, Bokay u 53, Budapest H 1083, Hungary
    Eur J Endocrinol 147:803-8. 2002
    Recent data have indicated the significance of vitamin D receptor (VDR) polymorphisms in type 1 diabetes mellitus (T1DM). We have studied the association of five known restriction enzyme polymorphisms of the VDR gene in patients with T1DM.
  13. ncbi Regulation of Vitamin D hydroxylases gene expression by 1,25-dihydroxyvitamin D3 and cyclic AMP in cultured human syncytiotrophoblasts
    Euclides Avila
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion, Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico D F, Mexico
    J Steroid Biochem Mol Biol 103:90-6. 2007
    ..D(3) [1,25(OH)(2)D(3)/calcitriol] through the activity of 25-hydroxyvitamin D(3)-1alpha-hydroxylase (CYP27B1) and 1,25(OH)(2)D(3)-24-hydroxylase (CYP24A1), the two key enzymes for Vitamin D metabolism...
  14. pmc Genetics of vitamin D 1alpha-hydroxylase deficiency in 17 families
    J T Wang
    Department of Pediatrics, University of California, San Francisco, USA
    Am J Hum Genet 63:1694-702. 1998
    Vitamin D-dependent rickets type I (VDDR-I), also known as pseudo-vitamin D-deficiency rickets, appears to result from deficiency of renal vitamin D 1alpha-hydroxylase activity. Prior work has shown that the affected gene lies on 12q13.3...
  15. ncbi Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter
    Regina Ebert
    Orthopedic Department, University of Wuerzburg, Wuerzburg, Germany
    Mol Endocrinol 18:2440-50. 2004
    ..Down-regulation of 1alpha-hydroxylase promoter through NFkappaB signaling may contribute to the pathogenesis of inflammation-associated osteopenia/osteoporosis...
  16. pmc Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, United Kingdom
    Am J Pathol 165:807-13. 2004
    ..We further postulate that this autocrine/paracrine action of 1alpha-hydroxylase may lead to increased circulating levels of 1,25(OH)2D3 and a form of HHM which is distinct from that seen with PTHrP-secreting tumors...
  17. pmc Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching
    Akiko Murayama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo, Japan
    EMBO J 23:1598-608. 2004
    Vitamin D receptor (VDR) is essential for ligand-induced gene repression of 25(OH)D3 1alpha-hydroxylase (1alpha(OH)ase) in mammalian kidney, while this gene expression is activated by protein kinase A (PKA) signaling downstream of the ..
  18. ncbi Vitamin D
    Adriana S Dusso
    Renal Division, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Physiol Renal Physiol 289:F8-28. 2005
    ..This vitamin D hormone activates its cellular receptor (vitamin D receptor or VDR), which alters the transcription rates of target genes responsible for the biological responses...
  19. ncbi Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells
    M van Driel
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    FASEB J 20:2417-9. 2006
    ..This is strongly dependent on osteoclast inducer RANKL. This study showing expression, activity, and functionality of 1alpha-hydroxylase unequivocally demonstrates that vitamin D can act in an auto/paracrine manner in bone...
  20. ncbi RNAi-mediated silencing of CYP27B1 abolishes 1,25(OH)2D3 synthesis and reduces osteocalcin and CYP24 mRNA expression in human osteosarcoma (HOS) cells
    P H Anderson
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Steroid Biochem Mol Biol 103:601-5. 2007
    ..to inhibit the mRNA encoding the enzyme responsible for 1,25D synthesis, 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1)...
  21. ncbi Splice variants of the CYP27b1 gene and the regulation of 1,25-dihydroxyvitamin D3 production
    S Wu
    Burns and Allen Research Institute, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, School of Medicine, California 90048, USA
    Endocrinology 148:3410-8. 2007
    The cytochrome P450 25-hydroxyvitamin D3-1alpha-hydroxylase (CYP27b1) plays a pivotal role in vitamin D physiology by catalyzing synthesis of active 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]...
  22. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
    ..is derived from its precursor 25-hydroxyvitamin D by the enzyme 1 alpha-hydroxylase encoded by the CYP27B1 gene and is inactivated by 24-hydroxylase encoded by the CYP24A1 gene...
  23. pmc Evidence for genetic regulation of vitamin D status in twins with multiple sclerosis
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford Oxford, United Kingdom
    Am J Clin Nutr 88:441-7. 2008
    ..Recent epidemiologic, experimental, and clinical evidence support an effect for low environmental supplies of vitamin D in mediating an increased susceptibility to MS...
  24. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    We systematically investigated the association of 48 SNPS in four vitamin D metabolizing genes [CYP27A1, GC, CYP27B1 and CYP24A1] with serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] levels and the ..
  25. ncbi 25-Hydroxyvitamin D3 1alpha-hydroxylase splice variants in benign and malignant ovarian cell lines and tissue
    Dorothea Fischer
    KIinik für Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, D 23562 Lubeck, Germany
    Anticancer Res 29:3627-33. 2009
    ..Their increased expression in malignancy is possibly bound to the reduction of enzyme activity, which may lead to the genesis of ovarian cancer. In the future, preventive and therapeutic activities may result from these findings...
  26. pmc Vitamin D metabolism and action in human bone marrow stromal cells
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Endocrinology 151:14-22. 2010
    ..D, 1 alpha,25-dihydroxyvitamin D [1,25(OH)(2)D] is catalyzed in several cell types by the 1 alpha-hydroxylase (CYP27B1), but little is known about the expression or regulation of CYP27B1 in human bones...
  27. pmc Confirmation of association between multiple sclerosis and CYP27B1
    Emilie Sundqvist
    Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Hum Genet 18:1349-52. 2010
    ..In the kidney, skin and immune cells, 25-OHD(3) is turned into bioactive 1,25(OH)(2)D(3) by the enzyme coded by CYP27B1 (cytochrome P450 family 27 subfamily B peptide 1) on chromosome 12q13.1-3...
  28. pmc Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: a study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions
    Nair Lopes
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
    BMC Cancer 10:483. 2010
    ..the Vitamin D receptor (VDR) and the synthesis and degradation of this hormone are regulated by the enzymes CYP27B1 and CYP24A1, respectively...
  29. pmc Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase
    J S Adams
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
    Arch Biochem Biophys 523:95-102. 2012
    Like the vitamin D receptor (VDR), the CYP27B1-hydroxylase is expressed widely in human tissues...
  30. pmc Altered expression of key players in vitamin D metabolism and signaling in malignant and benign thyroid tumors
    Isabelle Clinckspoor
    Laboratory for Experimental Medicine and Endocrinology, KU Leuven, Leuven, Belgium
    J Histochem Cytochem 60:502-11. 2012
    ..Vitamin D receptor (VDR) and CYP27B1 and CYP24A1 (respectively activating and catabolizing vitamin D) expression was studied (RT-PCR, ..
  31. doi Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma
    Anja Urbschat
    Faculty of Medicine, Goethe University Hospital, Frankfurt am Main, Germany
    Eur J Clin Invest 43:1282-90. 2013
    ..Concerning the synthesis of vitamin D, the hydroxylases CYP2R1, CYP27B1 and CYP24A1 play a critical role, and the latter molecule determines the biological half-life of 1,25(OH)2 D3 , ..
  32. ncbi A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans
    Elizabeth Ramos Lopez
    Department of Internal Medicine I, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany
    Eur J Endocrinol 151:193-7. 2004
    b>CYP27B1 hydroxylase catalyzes the conversion of 25 hydroxyvitamin D(3) (25OHD(3)) to 1,25(OH)(2)D(3), the most active natural vitamin D metabolite, which plays a role in the regulation of immunity and cell proliferation...
  33. ncbi A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population
    C E Jennings
    Institute of Human Genetics, School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    J Mol Endocrinol 34:859-63. 2005
    Previous studies have suggested an association between alleles of the CYP27B1 (1-alpha hydroxylase) gene and autoimmune conditions...
  34. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..D(3) (1,25D) derives from renal conversion of 25-hydroxyvitamin D(3) (25D), by the 25D 1 alpha-hydroxylase (CYP27B1)...
  35. ncbi 25-Hydroxyvitamin D3 1alpha-hydroxylase splice variants in breast cell lines MCF-7 and MCF-10
    D Fischer
    Klinik fur Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Cancer Genomics Proteomics 4:295-300. 2007
    ..With this study it is the first time that expression and alternative splicing of 1alpha-OHase in the human breast cancer cell line MCF-7 and thebenign breast cell line MCF-10A are described...
  36. pmc Vitamin D pathway gene variants and prostate cancer prognosis
    Sarah K Holt
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 70:1448-60. 2010
    ..Increased understanding of relevant germline genetic variation with disease outcome could aid in the development of vitamin-D-based therapies...
  37. pmc Expression of the vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) decreases during melanoma progression
    Anna A Brozyna
    Department of Tumor Pathology and Pathomorphology, Oncology Centre Prof Franciszek Łukaszczyk Memorial Hospital, The Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85 796 Bydgoszcz, Poland
    Hum Pathol 44:374-87. 2013
    1α-Hydroxylase (CYP27B1), the enzyme responsible for the synthesis of the biologically active form of vitamin D (1,25(OH)(2)D(3)), is expressed in the skin...
  38. ncbi Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1
    G K Fu
    Department of Pediatrics, Child Health Research Center, San Francisco, California 94121, USA
    Mol Endocrinol 11:1961-70. 1997
    ..Because its expression in the kidney is very low, we cloned and sequenced cDNA for 25-OHD-1 alpha-hydroxylase (P450c1 alpha) from human keratinocytes, in which 1 alpha-hydroxylase activity and mRNA expression can be induced to be ..
  39. ncbi No enzyme activity of 25-hydroxyvitamin D3 1alpha-hydroxylase gene product in pseudovitamin D deficiency rickets, including that with mild clinical manifestation
    S Kitanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan
    J Clin Endocrinol Metab 84:4111-7. 1999
    Pseudovitamin D deficiency rickets (PDDR) is an autosomal recessive disorder caused by defect in the activation of vitamin D...
  40. ncbi Vitamin D 1alpha-hydroxylase (CYP1alpha) polymorphism in Graves' disease, Hashimoto's thyroiditis and type 1 diabetes mellitus
    Michael A Pani
    Department of Internal Medicine I, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany
    Eur J Endocrinol 146:777-81. 2002
    ..Vitamin D 1alpha-hydroxylase (CYP1alpha) is one of the key enzymes regulating both systemic and tissue levels of 1,25-dihyroxyvitamin D(3) (1,25(OH)(2)D(..
  41. ncbi Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3
    Carly M Kemmis
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    J Nutr 136:887-92. 2006
    ..b>CYP27B1 is a cytochrome P450-containing hydroxylase expressed in kidney and other tissues that generates 1alpha,25(OH)2D3 ..
  42. ncbi CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients
    Elizabeth Ramos-Lopez
    Department of Internal Medicine I, Division of Endocrinology, Diabetes and Metabolism, University Hospital Frankfurt, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    J Steroid Biochem Mol Biol 103:807-10. 2007
    ..of these metabolites: the 25-Vitamin-D-hydroxylase (CYP2R1), the 25-hydroxyvitamin-D(3)-1-alpha-hydroxylase (CYP27B1) and the 25(OH)D(3)-24-hydroxylase (CYP24) among others...
  43. pmc Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway
    Carly M Kemmis
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Cell Biochem 105:980-8. 2008
    ..is synthesized from 25(OH)D3 (the major circulating form of the vitamin) by the mitochondrial enzyme CYP27b1 in renal and other tissues...
  44. ncbi Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells
    Jana Fritsche
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Blood 102:3314-6. 2003
    ..Terminal maturation renders DCs unresponsive to the effects of 1,25(OH)2D3, but those cells are able to suppress the differentiation of their own precursor cells in a paracrine way through the production of 1,25(OH)2D3...
  45. pmc Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene
    Yan Zhong
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 284:11059-69. 2009
    ....
  46. ncbi Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice
    Joost G J Hoenderop
    Department of Physiology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Kidney Int 65:531-9. 2004
    Pseudovitamin D deficiency rickets (PDDR) is an autosomal disease, characterized by undetectable levels of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), rickets and secondary hyperparathyroidism...
  47. ncbi Enzymatic studies on the key enzymes of vitamin D metabolism; 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24)
    K Inouye
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biotechnol Annu Rev 7:179-94. 2001
    The key enzymes of vitamin D3 metabolism, renal 25-hydroxyvitamin D3 1 alpha-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24) were expressed in Escherichia coli, and their enzymatic properties were revealed...
  48. ncbi [Association of the vitamin D receptor gene start codon polymorphism with vitamin D deficiency rickets]
    Hua Jun Lu
    Department of Pediatrics, The First Affiliated Hospital of Kunming Medical College, Kunming, 650032, China
    Zhonghua Er Ke Za Zhi 41:493-6. 2003
    ..Vitamin D receptor (VDR) gene has been used as one of genetic markers in studying the metabolic diseases of bone...
  49. ncbi 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bone Miner Res 20:305-17. 2005
    1,25(OH)2D3 induces gene expression through the VDR. We used chromatin immunoprecipitation techniques to explore this 1,25(OH)2D3-induced process on the 25-hydroxyvitamin D3-24-hydroxylase (Cyp24) and Opn gene promoters in intact ..
  50. ncbi The vitamin D3 receptor and retinoid X receptors in psoriatic skin: the receptor levels correlate with the receptor binding to DNA
    T Jensen
    Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark
    Br J Dermatol 138:225-8. 1998
    ..The effects of vitamin D3 are mediated through the vitamin D3 receptor (VDR). The VDR heterodimerizes with another transcriptional regulator, preferentially the retinoid X receptor (RXR)...
  51. ncbi Vitamin D receptor expression in chicken muscle tissue and cultured myoblasts
    S B Zanello
    , , Universidad Nacionaldel Sur, , Argentina
    Horm Metab Res 29:231-6. 1997
    ..Evidence of the presence of VDR is provided here, thus supporting the existence of a receptor-mediated mechanism of action of 1,25(OH)2D3...
  52. pmc A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer
    Haojie Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 4:e103. 2007
    ..to the active hormone 1,25 dihydroxyvitamin D3 (1,25[OH]2D), which, operating through the vitamin D receptor (VDR), inhibits in vitro cell proliferation, induces differentiation and apoptosis, and may protect against prostate ..
  53. ncbi Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the limbic system of the rat
    T Walbert
    , , Teichgraben 7, 07743 Jena, Germany
    Horm Metab Res 33:525-31. 2001
    ..to obtain a complete cellular and subcellular mapping of the 1,25-dihydroxyvitamin D3 receptor protein (VDR) in the rat limbic system...
  54. pmc Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes
    B K Lee
    Institute of Industrial Medicine, Soonchunhyang University, Chonan, Korea
    Environ Health Perspect 109:383-9. 2001
    ..that lead and selected genes known to modify the toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and delta-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk...
  55. ncbi 1H, 15N resonance assignment and three-dimensional structure of CYP1 (HAP1) DNA-binding domain
    J Timmerman
    , , Palaiseau, France
    J Mol Biol 259:792-804. 1996
    b>CYP1(HAP1) is a transcriptional activator involved in the aerobic metabolism of the yeast Saccharomyces cerevisiae. The amino acid sequence of its DNA-binding domain suggests that it belongs to the "zinc cluster" class...
  56. ncbi Vitamin D-resistant rickets and type 1 diabetes in a child with compound heterozygous mutations of the vitamin D receptor (L263R and R391S): dissociated responses of the CYP-24 and rel-B promoters to 1,25-dihydroxyvitamin D3
    Minh Nguyen
    INSERM Unité 561, Hopital St Vincent de Paul, Paris, France
    J Bone Miner Res 21:886-94. 2006
    ..vitamin D-resistant rickets, alopecia, and type 1 diabetes in a child with compound heterozygous mutations in the VDR gene...
  57. doi Progressive hearing loss in mice with a mutated vitamin D receptor gene
    Jing Zou
    Department of Otolaryngology, School of Medicine, University of Tampere, Tampere, Finland
    Audiol Neurootol 13:219-30. 2008
    ..Hormonal forms of vitamin D regulate transcription by binding with the high-affinity vitamin D receptor (VDR).
  58. ncbi [Exogenous estrogen improved calcium homeostasis and skeletal mineralization in vitamin D receptor gene knockout female mice.]
    Bing Yan Li
    Radiation Medical and Public School of Soochow University, Suzhou 215123, China E mail
    Sheng Li Xue Bao 58:573-6. 2006
    ..The genomic effect of 1alpha, 25(OH)(2)D(3)is mediated by the nuclear vitamin D receptor (VDR) in a ligand-dependent manner...
  59. ncbi Vitamin D and aging
    Pentti Tuohimaa
    Medical School, 33014 University of Tampere, Finland
    J Steroid Biochem Mol Biol 114:78-84. 2009
    ..In several studies, we have described that a complete or partial lack of vitamin D action (VDR-/- mice and CYP27B1-/-) show almost similar phenotype as FGF23-/- or Klotho-/- mice...
  60. pmc Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes
    B S Schwartz
    Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Environ Health Perspect 108:949-54. 2000
    ..the influence of polymorphisms in the [delta]-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genes on blood lead, tibia lead, and dimercaptosuccinic acid (DMSA)-chelatable lead levels in 798 lead workers and ..
  61. pmc Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor
    Peter J Malloy
    Department of Medicine, Stanford University School of Medicine, Room S025, Stanford, CA 94305, USA
    Mol Genet Metab 99:72-9. 2010
    ..disease, hereditary vitamin D resistant rickets (HVDRR), is caused by mutations in the vitamin D receptor (VDR) that result in resistance to the active hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3) or calcitriol)...
  62. ncbi Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells
    Pit Sertznig
    Department of Dermatology, The Saarland University Hospital, Homburg Saar, Germany
    Anticancer Res 29:3647-58. 2009
    The expression and signaling of the vitamin D receptor (VDR) and peroxisome proliferator-activated receptor (PPAR) alpha, delta, gamma was investigated in the melanoma cell line MeWo...
  63. pmc A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun
    T L Towers
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Cell Biol 19:4191-9. 1999
    ..stimuli and transcriptional repression by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] through the vitamin D3 receptor (VDR)...
  64. pmc Vitamin D and human health: lessons from vitamin D receptor null mice
    Roger Bouillon
    Katholieke Universiteit Leuven, Laboratory of Experimental Medicine and Endocrinology, Herestraat 49, O and N 1 bus 902, 3000 Leuven, Belgium
    Endocr Rev 29:726-76. 2008
    ..Absence of a functional VDR or the key activating enzyme, 25-OHD-1alpha-hydroxylase (CYP27B1), in mice creates a bone and growth plate phenotype that mimics humans with the same congenital disease or severe ..
  65. ncbi Natural metabolites of 1alpha,25-dihydroxyvitamin D(3) retain biologic activity mediated through the vitamin D receptor
    H Harant
    Department of Inflammatory Diseases, Novartis Research Institute, Vienna, Austria
    J Cell Biochem 78:112-20. 2000
    ..the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors...
  66. ncbi Vitamin D(3) receptor ablation alters mammary gland morphogenesis
    Glendon Zinser
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Development 129:3067-76. 2002
    ..The vitamin D(3) receptor (VDR), whose ligand 1,25-dihydroxyvitamin D(3) is the biologically active form of vitamin D(3), has been implicated in ..
  67. ncbi Effect of cellular environment on the selective activation of the vitamin D receptor by 1alpha,25-dihydroxyvitamin D3 and its analog 1alpha-fluoro-16-ene-20-epi-23-ene-26,27-bishomo-25-hydroxyvitamin D3 (Ro-26-9228)
    Ayesha Ismail
    Department of Endocrine Neoplasia and Hormonal Disorders, Unit 435, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Endocrinol 18:874-87. 2004
    ..In the human osteoblast-like cells, hFOB, the vitamin D receptor (VDR)-mediated transcriptional potencies of Ro-26-9228 and 1,25-dihydroxyvitamin D(3) (1,25D(3)) were similar, but in ..
  68. ncbi Minireview: vitamin D receptor: new assignments for an already busy receptor
    Anthony W Norman
    Department of Biochemistry and Biomedical Sciences, University of California, Riverside, California 92506, USA
    Endocrinology 147:5542-8. 2006
    ..The discovery in 1969 of the nuclear vitamin D receptor (VDR) for 1alpha,25(OH)2D3 initiated a two-decade-long proliferation of reports that collectively described the broad ..
  69. ncbi Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells
    Narasimha Swamy
    Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, 85 East Newton Street, Boston, MA 02118, USA
    Clin Cancer Res 10:8018-27. 2004
    The 25-hydroxyvitamin D(3) (25-OH-D(3)) is a nontoxic and low-affinity vitamin D receptor (VDR)-binding metabolic precursor of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)]...
  70. ncbi Targets of vitamin D receptor signaling in the mammary gland
    JoEllen Welsh
    Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA
    J Bone Miner Res 22:V86-90. 2007
    ..include detection of megalin-mediated uptake of vitamin D-binding protein (DBP) and identification of CYP27B1 and CYP24 metabolizing enzymes in mammary cells, demonstration of precocious mammary gland development in VDR-..
  71. doi Association of vitamin D receptor gene 3'-variants with Hashimoto's thyroiditis in the Croatian population
    M Stefanic
    Department of Nuclear Medicine, Radiation Protection and Pathophysiology, Clinical Hospital Osijek, Osijek, Croatia
    Int J Immunogenet 35:125-31. 2008
    ..Vitamin D receptor (VDR) endocrine system affects immunosuppressive, regulatory and tolerogenic decisions required for induction and ..
  72. pmc Inactivation of the human vitamin D receptor by caspase-3
    Peter J Malloy
    Division of Endocrinology, Gerontology, and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Endocrinology 150:679-86. 2009
    Calcitriol actions are mediated by the vitamin D receptor (VDR), a nuclear transcription factor of the steroid-retinoid-thyroid nuclear receptor gene superfamily...
  73. pmc The effects of 1 alpha,25-dihydroxyvitamin D(3) on matrix metalloproteinase and prostaglandin E(2) production by cells of the rheumatoid lesion
    L C Tetlow
    University Department of Medicine, Manchester Royal Infirmary, Manchester, UK
    Arthritis Res 1:63-70. 1999
    ..the biologically active metabolite of vitamin D3, acts through an intracellular vitamin D receptor (VDR) and has several immunostimulatory effects...
  74. ncbi Histamine receptor H1 and dermatopontin: new downstream targets of the vitamin D receptor
    Radhika R Pochampally
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Bone Miner Res 22:1338-49. 2007
    ..We analyzed co-expressed gene groups to identify new targets for known transcription factor VDR during differentiation...
  75. ncbi A novel mutation in the deoxyribonucleic acid-binding domain of the vitamin D receptor causes hereditary 1,25-dihydroxyvitamin D-resistant rickets
    N U Lin
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    J Clin Endocrinol Metab 81:2564-9. 1996
    Mutations in the vitamin D receptor (VDR) result in hereditary 1,25-dihydroxyvitamin D3-resistant rickets (HVDRR), an autosomal recessive disease caused by target organ resistance to the action of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]...
  76. ncbi Birthweight, vitamin D receptor genotype and the programming of osteoporosis
    E M Dennison
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Paediatr Perinat Epidemiol 15:211-9. 2001
    Studies of the association between polymorphisms of the gene for the vitamin D receptor (VDR) and adult bone mass have been inconsistent, pointing to the possibility that gene--environment interactions may vary in different populations...
  77. ncbi The impact of vitamin D receptor genotype on the management of anemia in hemodialysis patients
    Sehsuvar Erturk
    Department of Nephrology, Ankara University Medical School, Ibni Sina Hospital, Ankara, Turkey
    Am J Kidney Dis 40:816-23. 2002
    ..We hypothesized that the vitamin D receptor (VDR) genotype, which may differentiate response to endogenous or exogenous active vitamin D, has a role in the ..
  78. ncbi Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing
    Chi Zhang
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:35325-36. 2003
    Nuclear coactivator-62 kDa/Ski-interacting protein (NCoA62/SKIP) is a putative vitamin D receptor (VDR) and nuclear receptor coactivator protein that is unrelated to other VDR coactivators such as those in the steroid receptor ..
  79. pmc A novel bile acid-activated vitamin D receptor signaling in human hepatocytes
    Shuxin Han
    Department of Integrative Medical Sciences, Northeastern Ohio University s Colleges of Medicine and Pharmacy, 4209 State Route 44, Rootstown, Ohio 44272, USA
    Mol Endocrinol 24:1151-64. 2010
    Vitamin D receptor (VDR) is activated by natural ligands, 1alpha, 25-dihydroxy-vitamin D(3) [1alpha,25(OH)(2)-D(3)] and lithocholic acid (LCA)...
  80. doi BsmI, TaqI, ApaI, and FokI polymorphisms in the vitamin D receptor gene and periodontitis: a meta-analysis of 15 studies including 1338 cases and 1302 controls
    Hui Deng
    Department of Periodontology, The Affiliated Hospital of Stomatology, Wenzhou Medical College, Wenzhou, Zhejiang, China
    J Clin Periodontol 38:199-207. 2011
    A meta-analysis was conducted in order to investigate the potential association of vitamin D receptor (VDR) gene polymorphisms with susceptibility to aggressive and chronic periodontal disease.
  81. pmc Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers
    B S Schwartz
    Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 108:199-203. 2000
    We evaluated associations of tibial lead levels with polymorphisms in the vitamin D receptor (VDR) in 504 former organolead manufacturing workers with past exposure to lead...
  82. pmc Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice
    Yingben Xue
    Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47906 2059, USA
    Gastroenterology 136:1317-27, e1-2. 2009
    Vitamin D receptor (VDR)-knockout mice develop severe hypocalcemia and rickets, accompanied by disruption of active intestinal calcium absorption...
  83. ncbi Structural organization of the human vitamin D receptor chromosomal gene and its promoter
    K Miyamoto
    Department of Clinical Nutrition, Tokushima University, Japan
    Mol Endocrinol 11:1165-79. 1997
    The vitamin D receptor (VDR) is known to mediate the pleiotropic biological actions of 1,25-dihydroxyvitamin D3 through its ability to modulate the expression of target genes...
  84. ncbi Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease
    Y Ban
    Third Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Tokyo, Japan
    Thyroid 10:375-80. 2000
    ..on bone mineral density (BMD) and bone turnover are related to allelic variations in the vitamin D receptor (VDR) gene...
  85. ncbi Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease
    Y Ban
    Third Department of Internal Medicine, Showa University School of Medicine, Shinagawa, Japan
    Thyroid 10:475-80. 2000
    ..on bone mineral density (BMD) and bone turnover are related to allelic variations in the vitamin D receptor (VDR) gene...
  86. ncbi The Wilms' tumor gene product (WT1) modulates the response to 1,25-dihydroxyvitamin D3 by induction of the vitamin D receptor
    U Maurer
    Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany
    J Biol Chem 276:3727-32. 2001
    ..This is predominantly mediated by the nuclear receptor for 1,25-dihydroxyvitamin D(3), the vitamin D receptor (VDR)...
  87. ncbi Effects of vitamin D receptor inactivation on the expression of calbindins and calcium metabolism
    Y C Li
    Department of Medicine, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 281:E558-64. 2001
    Hypocalcemia, rickets, and osteomalacia are major phenotypic abnormalities in vitamin D receptor (VDR)-null mice...
  88. ncbi The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine
    H Yamamoto
    Department of Clinical Nutrition, School of Medicine, University of Tokushima, Tokushima, Japan
    J Bone Miner Res 14:240-7. 1999
    The actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2 D3) are mediated through the nuclear vitamin D receptor (VDR)...
  89. ncbi Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas
    Shozo Yano
    Division of Endocrinology Metabolism, Neurology, and Hematology Oncology, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur J Endocrinol 148:403-11. 2003
    A significant decrease in vitamin D receptor (VDR) and calcium-sensing receptor (CaSR) protein expression has been demonstrated recently in parathyroid (PT) adenomas...
  90. pmc Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 24:128-47. 2010
    The vitamin D receptor (VDR) mediates the endocrine actions of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and autoregulates the expression of its own gene in target cells...
  91. ncbi Vitamin D3 derivatives with adamantane or lactone ring side chains are cell type-selective vitamin D receptor modulators
    Yuka Inaba
    Department of Biochemistry, Nihon University School of Medicine, Tokyo, Japan
    Mol Pharmacol 71:1298-311. 2007
    The vitamin D receptor (VDR) mediates the biological actions of 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active form of vitamin D, which regulates calcium homeostasis, immunity, cellular differentiation, and other physiological ..
  92. pmc 25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue
    Ulrika Segersten
    Department of Surgical Sciences, Endocrine Unit, Uppsala University Hospital, SE 751 85 Uppsala, Sweden
    Breast Cancer Res 7:R980-6. 2005
    ..In addition, expression of the 25-hydroxyvitamin D3 24-hydroxylase (24-hydroxylase) and the vitamin D receptor (VDR) was investigated.
  93. ncbi Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms
    S J Van Cromphaut
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Leuven, Belgium
    J Bone Miner Res 18:1725-36. 2003
    ..CaT1 expression is reduced in ERKOalpha mice and induced by estrogen treatment, pregnancy, or lactation in VDR WT and KO mice...
  94. ncbi Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong
    Elin Grundberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Bone Miner Res 22:832-40. 2007
    The VDR is a prime candidate gene for osteoporosis. Here, we studied three common VDR haplotypes in relation to bone phenotypes in 5014 participants of the global MrOS Study...
  95. ncbi The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature
    Kim Köstner
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Anticancer Res 29:3511-36. 2009
    In recent years, the relevance of vitamin D receptor (VDR) gene restriction fragment length polymorphisms for various types of cancer has been investigated by a great number of studies...
  96. ncbi 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin
    X Y Li
    Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Endocrinol 13:1686-94. 1999
    ..We have investigated regulation of VDR levels in human skin in vivo and in cultured human keratinocytes...
  97. ncbi Reduced vitamin D receptor expression in parathyroid adenomas: implications for pathogenesis
    D Sudhaker Rao
    Bone and Mineral Metabolism Research Laboratory, Department of Medicine, Henry Ford Hospital, Detroit, MI, 48202 2689, USA
    Clin Endocrinol (Oxf) 53:373-81. 2000
    ..parathyroid hyperplasia, there is an increased set-point and decreased expression of both the calcium sensing receptor (CaSR) and the vitamin D receptor (VDR). Accordingly, we examined VDR and CaSR expression in parathyroid adenomas.
  98. ncbi ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men
    N H Bell
    Departments of Medicine, Pharmacology, and Pediatrics, Medical University of South Carolina, Charleston, USA
    J Lab Clin Med 137:133-40. 2001
    A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling...
  99. ncbi Short-chain fatty acids and colon cancer cells: the vitamin D receptor--butyrate connection
    Tanja Gaschott
    2nd Department of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Recent Results Cancer Res 164:247-57. 2003
    ..The aim of this study was to elucidate the role of the vitamin D receptor (VDR) in butyrate-induced cell differentiation and cell cycle arrest in Caco-2 cells, a human colon cancer cell line...
  100. ncbi Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians
    J E Collins
    Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Birmingham, UK
    Clin Endocrinol (Oxf) 60:618-24. 2004
    ..suppressing the proliferation of activated T cells, with its actions being directed through the vitamin D receptor (VDR)...

Research Grants69

  1. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
    ..cell lines to examine the molecular effect of calcitriol through the examination of the vitamin D receptor (VDR) and genes that it regulated both directly and indirectly...
  2. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..New agents are needed to treat UC and CD and prevent relapse. Vitamin D receptor (VDR), once activated by its endogenous hormone calcitriol (1,25(OH) 2D3), modulates signaling pathways in the ..
  3. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Candace S Johnson; Fiscal Year: 2012
    ..to calcitriol-mediated anti-proliferative effects despite intact signaling through the vitamin D receptor (VDR)...
  4. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2010
    This revised competitive renewal continues our research into the role of the vitamin D receptor (VDR) in regulating the response to the active hormone, 1,25-dihydroxyvitamin D3 (calcitriol)...
  5. John M Brehm; Fiscal Year: 2015
    ..We hypothesize that Vitamin D Receptor (VDR) binding is cell specific and influences gene expression in pathways that are relevant to asthma (such as response ..
  6. Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug Discovery
    John Norris; Fiscal Year: 2009
    ..The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3, mediates its effects through the vitamin D receptor (VDR), a member of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors...
  7. Diet by Gene Interactions Affecting Calcium and Bone Metabolism
    James C Fleet; Fiscal Year: 2010
    ..to test whether the less active "f" allele of the FokI start codon polymorphism in the human (vitamin D receptor) VDR gene make these mice more sensitive to the negative impact of dietary calcium depletion on bone...
  8. Bandana Chatterjee; Fiscal Year: 2016
    ..project to identify regulatory factors which, through cross-talk with androgen receptor (AR), vitamin D3 receptor (VDR) and E2F1, are integrally linked to the anti-proliferation action of D3...
  9. Peter W Jurutka; Fiscal Year: 2014
    ..evidence indicates that SNPs in VDR may influence circulating concentrations of 1,25(OH)2D;further, two enzymes, CYP27B1 and CYP24A1, are of particular importance in metabolic homeostasis of this molecule...
  10. Novel Risk Factors For Hypertension
    John P Forman; Fiscal Year: 2010
    ..between folate and vitamin B12 and the risk of incident HTN, and that polymorphisms in the vitamin D receptor (VDR) will modify the association between vitamin D levels and HTN...
  11. Maternal-fetal vitamin D status and child adiposity, insulin resistance and BP
    Susanna Y Huh; Fiscal Year: 2010
    ..maternal and cord blood 25-OH vitamin D levels, and 2) single nucleotide polymorphisms in child vitamin D receptor (VDR) and other genes that affect vitamin D metabolism or signaling, are associated with child adiposity, insulin ..
  12. Carlos Bernal-Mizrachi; Fiscal Year: 2014
    ..atherosclerosis in mice, and define whether the mechanism for increased atherosclerosis is vitamin D receptor (VDR) dependent in macrophages...
  13. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The enzyme 11-hydroxylase (CYP27b1;the rate limiting enzyme converting 25-hydroxyvitamin D3 to the most active form of vitamin D3, 1,25-dihydroxyvitamin D3) and the vitamin D receptor (VDR), a ..
  14. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..protein products are directly involved in the metabolism of vitamin D: 25-hydroxylase (CYP27A1), 1a-hydroxylase (CYP27B1), vitamin D binding protein (GC), 24- hydroxylase (CYP24A1), vitamin D receptor (VDR), and retinoic acid receptor ..
  15. Functional Vitamin D Receptor Gene Variants and Racial/Ethnic Cancer Disparities
    Robin Taylor Wilson; Fiscal Year: 2010
    ..The actions of vitamin D are mediated through the vitamin D receptor (VDR)...
  16. Sanjay M Mallya; Fiscal Year: 2014
    ..We recently discovered that cyclin D1 binds to the vitamin D receptor (VDR) and modulates vitamin D signaling...
  17. Mechanisms of Hypovitaminosis D Pain: Role of Nociceptor Sprouting.
    SARAH ELIZABETH TAGUE; Fiscal Year: 2010
    ..calculate the percentage of marker and projection target-specific subpopulations that express vitamin D receptor (VDR) and 1 alpha-hydroxylase...
  18. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..to the active metabolite, 11,25-dihydroxyvitamin D3 [1,25(OH)2D3], and induces adipocyte Vitamin D3 Receptor (VDR) signaling along with paracrine secretion of 1,25(OH)2D3 to surrounding mammary epithelial cells to regulate growth ..
  19. Vitamin D induction of antibacterial activity in gingival cells
    Gill Diamond; Fiscal Year: 2009
    ..Published data has demonstrated an association between polymorphisms of the vitamin D receptor (VDR) gene and early-onset periodontitis...
  20. Maternal Vitamin D Status and Preterm Birth
    Lisa M Bodnar; Fiscal Year: 2013
    ..intractable racial disparities in preterm birth 2 by focusing on maternal vitamin D status and vitamin D receptor (VDR) genetic variation...
  21. Vitamin D Status in Pulmonary Fibrosis
    Allan Ramirez; Fiscal Year: 2010
    ..pathways that inhibit the actions of TGF? led us to the study of signal transduction by Vitamin D and its receptor (VDR)...
  22. Sebastiano Gattoni-Celli; Fiscal Year: 2016
    ..to assess by immunohistochemical techniques the expression of the following biomarkers: vitamin D receptor (VDR), p21, tumor growth factor beta (TGFbeta), cyclooxygenase 2 (COX- 2), and NFkappaB...
  23. Vitamin D and Colorectal Cancer
    Richard V Benya; Fiscal Year: 2012
    ..We have recently demonstrated that cyp27A1 [required to convert cholecalciferol to 25(OH)D3] as well as cyp27B1 [required to convert 25(OH)D3 to 1,25(OH)2D3] are present in epithelial cells lining the normal human colon...
  24. Anastassios G Pittas; Fiscal Year: 2015
    ..A secondary hypothesis is that the effect of vitamin D is modified by specific Vitamin D Receptor (VDR) polymorphisms...
  25. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..response element binding (ERE-BP) for their ability to compete in trans with the liganded vitamin D receptor (VDR) and estrogen receptor 1 (ER1) for their cognate response elements, identifying them as nucleic acid binding ..
  26. Bioassay for Breast Cancer Prevention
    JoEllen Welsh; Fiscal Year: 2010
    ..studied the effects of vitamin D on breast cancer cells with the idea of targeting the vitamin D receptor (VDR) for cancer therapy...
  27. Dynamic Mechanisms of Vitamin D-Induced Gene Expression
    J Wesley Pike; Fiscal Year: 2012
    ..Specific Aim 1: To identify the 1,25(OH)2D3-independent and -dependent vitamin D receptor (VDR) cistromes and their properties in osteoblast precursors and to assess the changes that occur to these cistromes ..
  28. Yan Chun Li; Fiscal Year: 2016
    ..will compare effects of Western diet or dietary LCA on secondary BAs and colonic tumorigenesis in WT, VDR(-/-), Cyp27b1(-/-) and VDR(-/-)/Cyp27b1(-/-) mice...
  29. Dennis H Oh; Fiscal Year: 2014
    ..proposal is that, following doses of UV exposure associated with vitamin D photosynthesis, vitamin D receptor (VDR) independent of canonical vitamin D signaling is upregulated to mediate cellular responses that limit the ..
  30. Vitamin D and the Immune System
    Lawrence Steinman; Fiscal Year: 2012
    ..Genome-wide analysis of NFAT, Runx1 and vitamin D receptor (VDR) binding sites in CD4+T cell DNA isolated from EAE mice treated with vehicle or 1,25(OH)2D3 using ChIP-seq will ..
  31. Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
    John S Adams; Fiscal Year: 2010
    ..g. the vitamin D-hydroxylases and vitamin D receptor [VDR]), 2] TLR expression and 3] cytokine responses to particle stimulation...
  32. DANIEL DAVID BIKLE; Fiscal Year: 2014
    ..Mice lacking the vitamin D receptor (VDR) or lacking the enzyme (CYP27B1) critical for producing the key ligand for VDR, 1,25 dihydroxyvitamin D3 (1,25(OH)2D3), fail to activate their ..
  33. Ligand independent signaling by VDR in Keratinocytes
    Paul N MacDonald; Fiscal Year: 2010
    ..In contrast, our preliminary data show that genetic ablation of CYP27B1, the gene encoding the renal 1alpha- hydroxylase (1aOHase), the enzyme that generates the bioactive 1,25(OH)2D3 ..
  34. Guy Howard; Fiscal Year: 2015
    ..factors, plays a major role in the cooperative actions of HGF and 1,25OHD to up-regulate the vitamin D receptor (VDR) and promote MSC differentiation...
  35. Madhavi P Kadakia; Fiscal Year: 2016
    ..VD3 exerts its effects upon binding to the vitamin D receptor, VDR. We have previously shown that VDR is positively regulated by the most abundant and physiologically relevant p63 ..
  36. The role of Vitamin D metabolism in Non-Small Cell Lung Cancer
    Nithya Ramnath; Fiscal Year: 2012
    ..We will determine the relationship between Vitamin D receptor (VDR)/CYP24A1 gene expression and median survival (primary outcome)...
  37. GARSON DAVID ROODMAN; Fiscal Year: 2014
    ..conventional transcription factor complex component, but when overexpressed it binds at vitamin D receptor (VDR)- responsive promoters and functions as a novel VDR co-activator...
  38. Characterizing interactions of the VDR and the canonical Wnt signatling pathway
    Hilary F Luderer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Vitamin D receptor (VDR) is a nuclear receptor important for regulating calcium absorption. Humans with mutations in the VDR develop Hereditary Vitamin D Resistant Rickets...
  39. Vitamin D and Prostate Cancer: Biomarkers and Genetic Variation
    Marian L Neuhouser; Fiscal Year: 2012
    ..candidate genes, including those important for vitamin D activation [27-hydroxylase (CYP27A1), 1-1-hydroxylase (CYP27B1)], co-activation (NCOA1-3, SMAD3), deactivation [24-hydroxylase (CYP24A1)], transport [vitamin D binding protein ..
  40. TIMOTHY YEN; Fiscal Year: 2014
    ..We identified a small collection of genes that include the vitamin D receptor (VDR) and various associated interacting and downstream genes...
  41. Vitamin D Receptor Coactivators in Osteoblasts
    Paul N MacDonald; Fiscal Year: 2010
    ..It functions via the vitamin D receptor (VDR) to impact bone by increasing intestinal calcium absorption and by directly affecting osteoblast/osteoclast ..
  42. J Wesley Pike; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The vitamin D receptor (VDR) is a transcription factor that mediates the actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the nucleus of target cells...
  43. Pravin C Singhal; Fiscal Year: 2016
    ..Since Snail has been demonstrated to repress transcription of vitamin D receptor (VDR) and nephrin (a podocyte slit diaphragm protein), it carries a potential to alter renal cell phenotype...
  44. 1,25-Dihydroxyvitamin D and vitamin D Receptor Function in the Zebrafish Skeleton
    Rajiv Kumar; Fiscal Year: 2011
    ..elucidate the functions of 1a, 25-dihydroxyvitamin D3 (1a,25(OH)2D3) and its receptor, the 1a,25(OH)2D3 receptor (VDR), in tissues in which it does not have a role in trans-epithelial calcium (Ca) and phosphate (Pi) transport ("non-..
  45. Vitamin D Status, Vitamin D Receptor Gene Variants, and Hypertension Risk
    Lu Wang; Fiscal Year: 2011
    ..initial analyses of plasma 25(OH)D and genetic variants in vitamin D pathway (candidate genes including VDR, CYP27B1, CYP24A1, GC, RXRA, RXRB, and RXRG) in relation to BP and hypertension...
  46. Margherita T Cantorna; Fiscal Year: 2014
    ..iNKT cells require adequate vitamin D in utero and the expression of the vitamin D receptor (VDR) for both development and function...
  47. Paul N MacDonald; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The vitamin D receptor (VDR), its requisite hormonal ligand, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), as well as a host of nuclear receptor coactivators and corepressors coordinately control the ..
  48. RICHARD JAMES REYNOLDS; Fiscal Year: 2015
    ..We will perform genotyping of 3 relevant vitamin D receptor gene (VDR) SNPs and measure serum 25(OH)-vitamin D levels on all 1,600 cases and controls...
  49. Mitchell A Watsky; Fiscal Year: 2015
    ..on these hypotheses, are (1) Determine if Vit D affects corneal epithelial differentiation;(2) Examine the effects VDR knockout on corneal epithelial wound healing;and (3) Determine how Vit D is transported into the tear fluid...
  50. Marie Demay; Fiscal Year: 2015
    ..proposal are focused on identifying the molecular basis for the ligand dependent and independent actions of the VDR, using the skin as a model system. Like humans with VDR mutations, VDR null mice develop alopecia...
  51. Lu Wang; Fiscal Year: 2014
    ..initial analyses of plasma 25(OH)D and genetic variants in vitamin D pathway (candidate genes including VDR, CYP27B1, CYP24A1, GC, RXRA, RXRB, and RXRG) in relation to BP and hypertension...
  52. Vitamin D, Related Genes and Breast Cancer Risk
    Anne Zeleniuch-Jacquotte; Fiscal Year: 2013
    ..We will also assess genetic variation in vitamin D-related genes (CYP27A1, CYP24A1, DBP, VDR, and RXRA) and evaluate the joint effects of circulating 25(OH)D and variants in these genes on breast cancer risk...
  53. Margherita T Cantorna; Fiscal Year: 2016
    ..Our preliminary data show that the increased susceptibility of the vitamin D receptor (VDR) KO mice to experimental IBD is a result of altered T cell homing that results in few mucosal CD8aa regulatory T ..
  54. Pamela L Lutsey; Fiscal Year: 2014
    ..In exploratory analyses, we will also assess the relation of vitamin D receptor (VDR) gene polymorphisms to CVD risk, and evaluate whether relations of 25(OH)D to CVD are modified by VDR gene ..
  55. DANIEL DAVID BIKLE; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The transcriptional activity of the vitamin D receptor (VDR) is regulated by a number of coactivator and corepressor complexes, which bind to the VDR in a ligand (1,25(OH)2D3) dependent (coactivators)..
  56. Anna Di Rienzo; Fiscal Year: 2015
    ..Vitamin D acts by binding to the vitamin D receptor (VDR), which allows the VDR to heterodimerize with the retinoic X receptor (RXR) and to act as a transcription factor...
  57. Role of PKA in autoimmune diabetes through dendritic cells (DC) and regulatory T
    Hua Gu; Fiscal Year: 2010
    ..high levels of IL-2 and IL-10;and 3) NF-kB is constitutively activated and expression of vitamin D receptor (VDR) significantly up-regualted in PKAhi-DCs...
  58. Animal model of Gardner's syndrome, a life threatening form of familial cancer
    Yong Sik Bong; Fiscal Year: 2013
    ..In this proposal I build on some very exciting preliminary data regarding a role for the vitamin D receptor (VDR) in Gardner's syndrome, a derivative of familial adenomatous polyposis (FAP)...
  59. Yoshikazu Uchida; Fiscal Year: 2016
    ..demonstrated that S1P stimulates CAMP expression not only through the well-characterized vitamin D receptor (VDR)-dependent mechanism, but also by a NF-?B-C/EBP[unreadable]-dependent pathway that is independent of VDR...
  60. Adenoisen-PKA signaling axis in Treg development and homeostasis
    Hua Gu; Fiscal Year: 2011
    ..and biochemical studies reveal that expression of several genes such as expression of vitamin D receptor (VDR) is significantly up-regulated in PKAhi-DCs...
  61. Solar Exposure and Melanoma Survival
    Marianne Berwick; Fiscal Year: 2009
    ..2. Determine whether functional polymorphic variants in the vitamin D receptor affect survival from melanoma. 3. Investigate the interaction of lifetime solar exposure and polymorphisms in VDR and its effect on survival.
  62. Vitamin D & Calcium Regulation Biomarkers in Colon Cancer Risk Reduction
    Roberd Bostick; Fiscal Year: 2007
    ..Classically 1,25(OH)2D synthesis has been thought to be solely regulated by the action of 1,alpha(OH)ase (CYP27B1) on 25(OH)D (storage form of vitamin D) in the kidney...
  63. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..1,25(OH)2D3 exerts its actions to support the mineralized skeleton via liganding of the nuclear vitamin D receptor (VDR), which in turn recruits its retinoid X receptor (RXR)heterodimeric partner to recognize vitamin D responsive ..
  64. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..Finally, the role of vitamin D receptor (VDR) remains to be fully elucidated...
  65. VDR POLYMORPHISM, SUNLIGHT EXPOSURE AND COLON CANCER
    Polly Newcomb; Fiscal Year: 2001
    ..In vitro studies have shown that vitamin D, mediated by the vitamin D receptor (VDR) plays an important role in the proliferation and differentiation of colorectal cancer cells...
  66. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2007
    ..of the proposed continuing research is to elucidate the molecular functions of the nuclear vitamin D receptor (VDR), which is known to cooperate with the retinoid X receptor (RXR) in order to mediate the actions of the vitamin D ..
  67. STRUCTURE/FUNCTION STUDIES OF THE VITAMIN D RECEPTOR
    G Whitfield; Fiscal Year: 1993
    ..research project is to gain further information and insight into the mode of action of the vitamin D receptor (VDR)...
  68. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..Our findings will have important implications with respect to Pi homeostasis, bone mineralization in mammals and humans, and the regulation of ion transport through Wnt signaling in the kidney. ..
  69. Vitamin D: A Negative Regulator of Renin Expression
    Yan Chun Li; Fiscal Year: 2003
    ..We demonstrated that the renin up-regulation is independent of the hypocalcemia associated with vitamin D receptor (VDR) ablation in VDR knockout (VDRKO) mice, but whether the secondary hyperparathyroidism associated with VDR ..