CYP1B1

Summary

Gene Symbol: CYP1B1
Description: cytochrome P450 family 1 subfamily B member 1
Alias: ASGD6, CP1B, CYPIB1, GLC3A, P4501B1, cytochrome P450 1B1, aryl hydrocarbon hydroxylase, cytochrome P450, family 1, subfamily B, polypeptide 1, cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile), flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Species: human

Top Publications

  1. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
  2. ncbi Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
  3. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
  4. doi Heterozygous loss-of-function variants in CYP1B1 predispose to primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 51:249-54. 2010
  5. doi Functional analysis of CYP1B1 mutations and association of heterozygous hypomorphic alleles with primary open-angle glaucoma
    M P López-Garrido
    Laboratorio de Genetica Molecular Humana, Facultad de Medicina Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, Avda de Almansa, No 14, 02006, Albacete, Spain
    Clin Genet 77:70-8. 2010
  6. ncbi Lack of association of CYP1 B1*3 polymorphism and ovarian cancer in a Caucasian population
    E Cecchin
    Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico National Cancer Institute, Aviano, Italy
    Int J Biol Markers 19:160-3. 2004
  7. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
  8. ncbi Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review
    Valentina Paracchini
    Scientific Direction, Ospedale Maggiore, Milan, Italy
    Am J Epidemiol 165:115-25. 2007
  9. pmc Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma
    Ashima Bhattacharjee
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology Council of Scientific and Industrial Research, Kolkata, India
    Mol Vis 14:841-50. 2008
  10. pmc Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol
    Fatemeh Suri
    School of Biology, University College of Science, University of Tehran, Tehran, Iran
    Mol Vis 14:2349-56. 2008

Research Grants

  1. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
  2. MAMMARY ESTROGEN METABOLISM AND BREAST CANCER RISK
    Fritz Parl; Fiscal Year: 2004
  3. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
  4. Bhagavatula Moorthy; Fiscal Year: 2015
  5. Yuichiro Tanaka; Fiscal Year: 2016
  6. Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion
    Jennifer J Schlezinger; Fiscal Year: 2010
  7. Steven M Kawut; Fiscal Year: 2016
  8. CYP1B1: A Molecular Target for Chemoprevention of Lung Adenocarcinoma
    Margie L Clapper; Fiscal Year: 2013
  9. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
  10. Alvaro Puga; Fiscal Year: 2015

Detail Information

Publications238 found, 100 shown here

  1. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..including CYP17 (5'-untranslated region T-->C), CYP19 [intron 4 (TTTA)(n = 7-13) and a 3-bp deletion (-3)], CYP1B1 (Val(432)Leu), and COMT (Val(108/158)Met)...
  2. ncbi Genetic variation of Cytochrome P450 1B1 (CYP1B1) and risk of breast cancer among Polish women
    Mia M Gaudet
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20852, USA
    Pharmacogenet Genomics 16:547-53. 2006
    Four single nucleotide polymorphisms (SNPs) in CYP1B1 (Ex2 + 143 C > G, Ex2 + 356 G > T, Ex3 + 251 G > C, Ex3 + 315 A > G) cause amino acid changes (R48G, A119S, L432V and N453S, respectively) and are associated with increased ..
  3. doi A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers
    Shanbeh Zienolddiny
    Section of Toxicology, Department of Biological and Chemical Work Environment, National Institute of Occupational Health N 0033, Oslo, Norway
    Carcinogenesis 29:1164-9. 2008
    ..Our results indicate that several SNPs in the phase I genes, CYP1B1, CYP2D6, CYP2E1 and CYP3A4, are associated with the risk of NSCLC...
  4. doi Heterozygous loss-of-function variants in CYP1B1 predispose to primary open-angle glaucoma
    Francesca Pasutto
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Invest Ophthalmol Vis Sci 51:249-54. 2010
    Although primary congenital glaucoma (PCG)-associated CYP1B1 mutations in the heterozygous state have been evaluated for association with primary open-angle glaucoma (POAG) in several small studies, their contribution to the occurrence of ..
  5. doi Functional analysis of CYP1B1 mutations and association of heterozygous hypomorphic alleles with primary open-angle glaucoma
    M P López-Garrido
    Laboratorio de Genetica Molecular Humana, Facultad de Medicina Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, Avda de Almansa, No 14, 02006, Albacete, Spain
    Clin Genet 77:70-8. 2010
    ..Recent reports have indicated that heterozygous mutations of the CYTOCHOROME P4501B1 (CYP1B1) gene are present in 4-10% of patients with primary open-angle glaucoma (POAG)...
  6. ncbi Lack of association of CYP1 B1*3 polymorphism and ovarian cancer in a Caucasian population
    E Cecchin
    Experimental and Clinical Pharmacology Unit, Centro di Riferimento Oncologico National Cancer Institute, Aviano, Italy
    Int J Biol Markers 19:160-3. 2004
    b>CYP1B1 is the enzyme with the highest efficiency of conversion of estradiol to 4-hydroxyestradiol in humans...
  7. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population.
  8. ncbi Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review
    Valentina Paracchini
    Scientific Direction, Ospedale Maggiore, Milan, Italy
    Am J Epidemiol 165:115-25. 2007
    The association between the cytochrome P-450 1B1 (CYP1B1) Val432Leu polymorphism and breast cancer was assessed through a meta-analysis of all published case-control studies and a pooled analysis of both published and unpublished case-..
  9. pmc Leu432Val polymorphism in CYP1B1 as a susceptible factor towards predisposition to primary open-angle glaucoma
    Ashima Bhattacharjee
    Molecular and Human Genetics Division, Indian Institute of Chemical Biology Council of Scientific and Industrial Research, Kolkata, India
    Mol Vis 14:841-50. 2008
    Defects in cytochrome P450 1B1 (CYP1B1) cause primary congenital glaucoma. However, defects in the gene have also been reported in primary open-angle glaucoma (POAG)...
  10. pmc Screening of common CYP1B1 mutations in Iranian POAG patients using a microarray-based PrASE protocol
    Fatemeh Suri
    School of Biology, University College of Science, University of Tehran, Tehran, Iran
    Mol Vis 14:2349-56. 2008
    The gene coding cytochrome P4501B1 (CYP1B1) has been shown to be a major cause of primary congenital glaucoma in the Iranian population. More recently it was shown to also be important in juvenile-onset open angle glaucoma (JOAG)...
  11. pmc CYP1B1 gene analysis in primary congenital glaucoma in Indonesian and European patients
    R Sitorus
    Department of Paediatric Ophthalmology, Strabismology and Ophthalmogenetics, Klinikum, University of Regensburg, Germany
    J Med Genet 40:e9. 2003
  12. ncbi [Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]
    T C Zimarina
    Mol Biol (Mosk) 38:386-93. 2004
    b>CYP1B1 and COMT code for the key enzymes of catecholestrogen biosynthesis and metabolism, and their polymorphisms determine a variation of enzymic activities...
  13. pmc Disease-causing mutations in proteins: structural analysis of the CYP1B1 mutations causing primary congenital glaucoma in humans
    Malkaram S Achary
    Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
    Biophys J 91:4329-39. 2006
    In this communication, we report an in-depth structure-based analysis of the human CYP1b1 protein carrying disease-causing mutations that are discovered in patients suffering from primary congenital glaucoma (PCG)...
  14. ncbi Prevalence of CYP1B1 mutations in Australian patients with primary congenital glaucoma
    D P Dimasi
    Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, Australia
    Clin Genet 72:255-60. 2007
    Analysis of CYP1B1 in primary congenital glaucoma (PCG) patients from various ethnic populations indicates that allelic heterogeneity is high, and some mutations are population specific...
  15. doi CYP1B1 and MYOC mutations in 116 Chinese patients with primary congenital glaucoma
    Yuhong Chen
    Department of Ophthalmology and Vision Science, Eye and Ear Nose Throat Hospital, Shanghai Medical School, Fudan University, Shanghai, China
    Arch Ophthalmol 126:1443-7. 2008
    To clinically characterize 116 Chinese patients with primary congenital glaucoma and to determine the role of CYP1B1 and MYOC mutations in this cohort.
  16. ncbi Isolation and characterization of the human cytochrome P450 CYP1B1 gene
    Y M Tang
    Department of Pharmacology and Toxicology, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 271:28324-30. 1996
    ..TCDD) and represents the first member of a new subfamily designated cytochrome P4501B1 (CYP1B1; Sutter, T. R., Tang, Y. M., Hayes, C. L., Wo, Y. P., Jabs, E. W., Li, X., Yin, H., Cody, C. W...
  17. pmc Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia
    B A Bejjani
    Department of Molecular Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 62:325-33. 1998
    ..Sequence analysis of the coding exons for cytochrome P4501B1 (CYP1B1) in these 25 families revealed three distinctive mutations that segregate with the phenotype in 24 ..
  18. pmc Sequence analysis and homology modeling suggest that primary congenital glaucoma on 2p21 results from mutations disrupting either the hinge region or the conserved core structures of cytochrome P4501B1
    I Stoilov
    Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1100, USA
    Am J Hum Genet 62:573-84. 1998
    We recently reported three truncating mutations of the cytochrome P4501B1 gene (CYP1B1) in five families with primary congenital glaucoma (PCG) linked to the GLC3A locus on chromosome 2p21...
  19. ncbi Characterization and functional analysis of two common human cytochrome P450 1B1 variants
    R A McLellan
    Division of Molecular Toxicology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Arch Biochem Biophys 378:175-81. 2000
    b>Cytochrome P450 1B1 (CYP1B1) is a human extrahepatic P450 that activates procarinogens, metabolizes 17beta-estradiol, and may well have a role in the pathogenesis of some forms of cancer...
  20. ncbi Primary congenital glaucoma: three case reports on novel mutations and combinations of mutations in the GLC3A (CYP1B1) gene
    K G Michels-Rautenstrauss
    Institute of Human Genetics, Erlangen, Germany
    J Glaucoma 10:354-7. 2001
    To describe three patients with congenital glaucoma homozygous and compound heterozygous for different mutations and benign sequence variants in the cytochrome P 450 1B1 (CYP1B1) gene.
  21. ncbi Functional analysis of six different polymorphic CYP1B1 enzyme variants found in an Ethiopian population
    Eleni Aklillu
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Pharmacol 61:586-94. 2002
    b>Cytochrome P450 1B1 (CYP1B1) is an extrahepatic enzyme of potential importance for the metabolism of estrogen and for metabolic activation of environmental carcinogens...
  22. ncbi Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..variation in mammographic breast density, by 10 polymorphisms in eight candidate genes (CYP17, CYP19, CYP1A1, CYP1B1, COMT, UGT1A1, AR, and AIB1). Breast density was assessed using a computer-assisted technique...
  23. pmc Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women
    K M Lee
    Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Chongno Gu, Seoul, Korea
    Br J Cancer 88:675-8. 2003
    A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1 Leu(432)Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls...
  24. ncbi Single amino acid mutations, but not common polymorphisms, decrease the activity of CYP1B1 against (-)benzo[a]pyrene-7R-trans-7,8-dihydrodiol
    Jennifer S Mammen
    Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
    Carcinogenesis 24:1247-55. 2003
    ..b>Cytochrome P450 1B1 (CYP1B1), a central enzyme in the activation of the ubiquitous environmental carcinogen benzo[a]pyrene (B[a]..
  25. ncbi Identification of R368H as a predominant CYP1B1 allele causing primary congenital glaucoma in Indian patients
    Aramati B M Reddy
    L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 44:4200-3. 2003
    To investigate the predominant mutation in the CYP1B1 gene in patients in India with primary congenital glaucoma (PCG), using PCR-restriction fragment length polymorphism (RFLP) methods and to characterize the molecular defect in two ..
  26. ncbi Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk
    Monique Saintot
    Groupe d Epidémiologie Métabolique, INSERM CRLC, Montpellier, France
    Int J Cancer 107:652-7. 2003
    ..cancer, we studied the interaction effects (ORi) between smoking habits and the gene polymorphisms of Cytochrome P450 1B1 (Val432Leu CYP1B1), Phenol-sulfotransferase 1A1 (Arg213His SULT1A1) and Catechol-O-methyltransferase (..
  27. pmc Polymorphisms in the CYP1B1 gene are associated with increased risk of prostate cancer
    B L Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Br J Cancer 89:1524-9. 2003
    b>CYP1B1 has been evaluated as a candidate gene for various cancers because of its function in activating environmental procarcinogens and catalysing the conversion of oestrogens to genotoxic catechol oestrogens...
  28. ncbi Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer
    Mette Sørensen
    Institute of Cancer Epidemiology, The Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen O, Denmark
    Cancer Lett 221:185-90. 2005
    ..study, we have investigated the occurrence of lung cancer in relation to polymorphisms in the phase I gene cytochrome P450 1B1 and in the phase II genes glutathione S-transferase A1, NAD(P)H quinone oxidoreductase and N-..
  29. ncbi Association of a common coding polymorphism (N453S) of the cytochrome P450 1B1 (CYP1B1) gene with optic disc cupping and visual field alteration in French patients with primary open-angle glaucoma
    Rahma Melki
    1INSERM, Unit 580, Paris, France
    Mol Vis 11:1012-7. 2005
    To investigate a role of common polymorphisms of the CYP1B1 gene in French patients with primary open-angle glaucoma (POAG).
  30. ncbi Primary congenital glaucoma and Rieger's anomaly: extended haplotypes reveal founder effects for eight distinct CYP1B1 mutations
    Gabriela Chavarria-Soley
    Institute of Human Genetics, Friedrich Alexander University, Erlangen, Germany
    Mol Vis 12:523-31. 2006
    Mutations in the cytochrome P450 1B1 (CYP1B1) gene are a frequent cause of primary congenital glaucoma (PCG) in different ethnic groups...
  31. ncbi The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..Genetic variants in CYP1B1 (rs1056827, rs1800440, rs10012) were strongly associated with urine 1-OHPG with P-values < 0.010...
  32. ncbi Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women
    Ruth Warren
    Department of Radiology, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1502-8. 2006
    ..17-OH-progesterone, estrone, and estrone sulfate] and 15 SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were studied...
  33. ncbi CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population
    Pia Sillanpää
    Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, Helsinki, Finland
    Breast Cancer Res Treat 104:287-97. 2007
    We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk...
  34. ncbi Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer
    S Marsh
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Pharmacogenomics J 7:362-5. 2007
    ..We found no association between ABCB1, ABCG2, CYP1B1, CYP3A4, CYP3A5 and CYP2C8 genotypes and paclitaxel clearance...
  35. pmc Contributions of MYOC and CYP1B1 mutations to JOAG
    Behnaz Bayat
    National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
    Mol Vis 14:508-17. 2008
    To investigate the role of MYOC and CYP1B1 in Iranian juvenile open angle glaucoma (JOAG) patients.
  36. pmc Investigation of CYP1B1 mutations in Chinese patients with primary congenital glaucoma
    Mei Yang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, PR China
    Mol Vis 15:432-7. 2009
    This study was conducted to investigate the mutation spectrum of the cytochrome P450 gene (CYP1B1) in Chinese patients with primary congenital glaucoma (PCG).
  37. pmc Mutation spectrum of CYP1B1 in North Indian congenital glaucoma patients
    Mukesh Tanwar
    Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, AIIMS, New Delhi, India
    Mol Vis 15:1200-9. 2009
    Mutations in Cytochrome P450 (CYP1B1) are a predominant cause of congenital glaucoma. This study was planned with the aim to identify the mutation profile of CYP1B1 in North Indian primary congenital glaucoma (PCG) patients.
  38. ncbi A novel frameshift founder mutation in the cytochrome P450 1B1 (CYP1B1) gene is associated with primary congenital glaucoma in Morocco
    A Belmouden
    Laboratoire de Biologie Cellulaire et Moleculaire, Faculte des Sciences, Université Ibnou Zohr, Agadir, Morocco
    Clin Genet 62:334-9. 2002
    ..A member of the cytochrome P450 gene family, CYP1B1, was found to be mutated in PCG patients in different populations, albeit to a variable extent...
  39. ncbi Genetic polymorphisms in CYP1A1, CYP1B1, COMT, GSTP1 and NAT2 genes and association with bladder cancer risk in a French cohort
    Luc Fontana
    université Clermont 1, Faculte de Medecine, 28 Place Henri Dunant, 63001 Clermont Ferrand Cedex 01 France
    Anticancer Res 29:1631-5. 2009
    ..Polymorphisms in genes coding to metabolising enzymes, resulting in variation of carcinogen detoxification efficiency, may therefore change the response of individuals to chemical carcinogens and be associated with an increased BC risk...
  40. pmc Expression profiling of CYP1B1 in oral squamous cell carcinoma: counterintuitive downregulation in tumors
    Shalmali Pradhan
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, Karnataka, India
    PLoS ONE 6:e27914. 2011
    ..A prodrug approach is thought to aid in targeting chemotherapy. CYP1B1, a member of cytochrome P450 family, has been implicated in chemical carcinogenesis...
  41. ncbi Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2
    T R Sutter
    Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205
    J Biol Chem 269:13092-9. 1994
    ..This predicted protein identifies a new gene subfamily of cytochrome P450, cytochrome P4501B1 (CYP1B1), that maps to human chromosome 2...
  42. pmc Identification of a single ancestral CYP1B1 mutation in Slovak Gypsies (Roms) affected with primary congenital glaucoma
    M Plasilova
    Department of Molecular Biology, Comenius University, Bratislava, Slovakia
    J Med Genet 36:290-4. 1999
    ..At this locus, mutations in the cytochrome P4501B1 (CYP1B1) gene have been identified as a molecular basis for this condition...
  43. ncbi Case-control study of ovarian cancer and polymorphisms in genes involved in catecholestrogen formation and metabolism
    M T Goodman
    Cancer Etiology Program, Cancer Research Center, University of Hawaii, Honolulu 96813, USA
    Cancer Epidemiol Biomarkers Prev 10:209-16. 2001
    ..The high-activity Val432 allele of the CYP1B1 gene, which may be linked to oxidative stress through elevated 4-hydroxylated catecholestrogen formation, was ..
  44. ncbi Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue
    Y Ko
    Department of Internal Medicine Medizinische Universitäts Poliklinik, University of Bonn, 53111 Bonn, Germany
    Cancer Res 61:4398-404. 2001
    ..of a case-control study that investigated the effects that the genetic variants of the cytochrome (CYP)1A1, CYP1B1, glutathione-S-transferase (GST)M1, GSTT1, and GSTP1 genes have on modifying the risk of smoking-related HNSCC...
  45. pmc Phenotypic heterogeneity of CYP1B1: mutations in a patient with Peters' anomaly
    A Vincent
    J Med Genet 38:324-6. 2001
  46. pmc Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene
    Andrea L Vincent
    Department of Ophthalmology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Am J Hum Genet 70:448-60. 2002
    ..We studied the role of MYOC, CYP1B1, and PITX2 in a population (n=60) affected with juvenile or early-onset glaucoma from the greater Toronto area...
  47. ncbi Primary congenital glaucoma: a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1,555dup mutation in the GLC3A (CYP1B1) gene in 2 families of different ethnic origin
    Gabriela Chavarria Soley
    Escuela de Biologia, Universidad de Costa Rica
    J Glaucoma 12:27-30. 2003
    To present new molecular genetic data on primary congenital glaucoma from 2 families, 1 isolated case and 3 familial cases due to mutations in the cytochrome P-450 1B1 (CYP1B1) gene.
  48. ncbi CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor alpha and estrogen receptor beta expressions
    Masahiro Sasaki
    Department of Urology, University of California San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Cancer Res 63:3913-8. 2003
    The estradiol metabolites by CYP1B1 received particular attention because of their causative role in malignant transformation of endometrium...
  49. ncbi CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC study
    Bharat Thyagarajan
    School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
    Cancer Lett 207:183-9. 2004
    ..We evaluated the association between breast cancer and Val432Leu polymorphism in the CYP1B1 gene and the tetranucleotide repeats in intron 4 of the CYP19 gene...
  50. ncbi GST, NAT, SULT1A1, CYP1B1 genetic polymorphisms, interactions with environmental exposures and bladder cancer risk in a high-risk population
    Rayjean J Hung
    International Agency for Research on Cancer, Lyon, France
    Int J Cancer 110:598-604. 2004
    ..b>Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines...
  51. pmc CYP1B1 mutations in French patients with early-onset primary open-angle glaucoma
    R Melki
    INSERM U580, Hopital Necker, Paris, France
    J Med Genet 41:647-51. 2004
    ..The CYP1B1 gene, a member of the cytochrome P450 gene family, is a major cause of primary congenital glaucoma (PCG), a rare ..
  52. ncbi An investigation of mammographic density and gene variants in healthy women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 112:683-8. 2004
    ..Following DNA extraction, samples were analyzed for polymorphisms in the COMT (Val158Met), CYP1A1 (Ile462Val), CYP1B1 (Val432Leu), CYP1A2 (*1F) and CYP17 (T27C) genes using PCR-RFLP...
  53. ncbi Myocilin gene implicated in primary congenital glaucoma
    K Kaur
    Kallam Anji Reddy Molecular Genetics Laboratory, Hyderabad, Andhra Pradesh, India
    Clin Genet 67:335-40. 2005
    Primary congenital glaucoma (PCG) has been associated with CYP1B1 gene (2p21), with a predominantly autosomal recessive mode of inheritance. Our earlier studies attributed CYP1B1 mutations to only 40% of Indian PCG cases...
  54. ncbi Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population
    Geyu Liang
    School of Public Health, Southeast University, Nanjing, 210009, China
    Cancer Lett 223:265-74. 2005
    ..In our study, the possibility of an association of CYP1B1, GSTP1 and hOGG1 genetic polymorphisms with lung cancer was investigated in Chinese population of Nanjing, by a ..
  55. pmc Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study
    Sarah J Lord
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Breast Cancer Res 7:R336-44. 2005
    ..Identifying genetic variants that determine increases in mammographic density in hormone users may be important in understanding hormonal carcinogenesis of the breast...
  56. ncbi Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
    ..cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a transcription ..
  57. ncbi Globally, CYP1B1 mutations in primary congenital glaucoma are strongly structured by geographic and haplotype backgrounds
    Subhabrata Chakrabarti
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 47:43-7. 2006
    To obtain a global perspective on the distribution and evolution of CYP1B1 mutations in primary congenital glaucoma (PCG) worldwide.
  58. ncbi Molecular and clinical evaluation of primary congenital glaucoma in Kuwait
    Suad Alfadhli
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, PO Box 31470 Sulaibekhat, Kuwait
    Am J Ophthalmol 141:512-6. 2006
    To report the spectrum of the CYP1B1 mutation in Kuwaiti patients with primary congenital glaucoma (PCG).
  59. ncbi CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 25:287-94. 2006
    To investigate the involvement of the CYP17, SRD5A2, CYP1B1, and CYP2D6 variants with prostate cancer, a case-control study of 100 patients and an equal number of age-matched control men was conducted...
  60. ncbi Genotype and phenotype correlations in congenital glaucoma: CYP1B1 mutations, goniodysgenesis, and clinical characteristics
    David A Hollander
    Glaucoma Research Laboratory, Department of Ophthalmology, University of California, San Francisco, California 94143 073, USA
    Am J Ophthalmol 142:993-1004. 2006
    To determine whether there is a correlation among mutations in the cytochrome P4501B1 gene (CYP1B1), the degree of angle dysgenesis observed histologically, and disease severity in congenital glaucoma.
  61. ncbi A clinical and molecular genetic study of Egyptian and Saudi Arabian patients with primary congenital glaucoma (PCG)
    Mohamed F El-Ashry
    Department of Molecular Genetics, Institute of Ophthalmology, London EC1V 9EL, UK
    J Glaucoma 16:104-11. 2007
    To undertake mutation screening of cytochrome P4501B1 (CYP1B1, OMIM 601771) and myocilin (MYOC, OMIM 601652) genes in Egyptian and Saudi Arabian patients with primary congenital glaucoma (PCG).
  62. ncbi Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma
    Emmanuelle Jeannot
    INSERM, U674, Génomique fonctionnelle des tumeurs solides, Paris, France
    Cancer Res 67:2611-6. 2007
    ..In contrast, we identified a CYP1B1 germ line heterozygous mutation in 4 of 32 women presenting HNF1alpha-mutated adenomas compared with none in 58 ..
  63. pmc CYP1B1 mutation profile of Iranian primary congenital glaucoma patients and associated haplotypes
    Fereshteh Chitsazian
    National Institute for Genetic Engineering and Biotechnology, Tehran, Iran
    J Mol Diagn 9:382-93. 2007
    The mutation spectrum of CYP1B1 among 104 primary congenital glaucoma patients of the genetically heterogeneous Iranian population was investigated by sequencing...
  64. ncbi Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens
    Olivier Cussenot
    Centre de Recherche pour les Pathologies Prostatiques, Tenon Hospital, Paris, France
    J Clin Oncol 25:3596-602. 2007
    The association between common functional polymorphisms from the CYP17, CYP19, CYP1B1, and COMT genes involved in the estrogen metabolism and the risk of prostate carcinoma was evaluated.
  65. ncbi Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer
    Sharon Marsh
    Washington University School of Medicine, Division of Oncology, St Louis, MO 63110, USA
    J Clin Oncol 25:4528-35. 2007
    ....
  66. pmc CYP1B1 variants are associated with prostate cancer in non-Hispanic and Hispanic Caucasians
    Joke Beuten
    Department of Cellular and Structural Biology
    Carcinogenesis 29:1751-7. 2008
    b>Cytochrome P450 1B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones...
  67. doi Association of functionally important polymorphisms in cytochrome P4501B1 with lung cancer
    Parag P Shah
    Developmental Toxicology Division, Indian Institute of Toxicology Research formerly Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Mutat Res 643:4-10. 2008
    In the present study, genotype and haplotype frequencies of four polymorphisms of cytochrome P450 1B1 (CYP1B1) that cause amino acid changes (Arg-Gly at codon 48, Ala-Ser at codon 119, Leu-Val at 432 and Asn-Ser at codon 453) were ..
  68. doi CYP1B1 gene analysis in primary congenital glaucoma Brazilian patients: novel mutations and association with poor prognosis
    Mauricio Della Paolera
    Department of Ophthalmology, Glaucoma Service, Faculty of Medical Sciences, Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo, SP, Brazil
    J Glaucoma 19:176-82. 2010
    To determine the spectrum of CYP1B1 gene mutations in Brazilian patients with primary congenital glaucoma, and to correlate the presence of alterations in the CYP1B1 gene sequence with clinical aspects of the disease.
  69. doi Genetic polymorphisms in cytochrome P450 genes are associated with an increased risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population
    Jun Tai
    Department of Otolaryngology and Head and Neck Surgery, Affiliated Beijing Tongren Hospital, Capital University of Medical Sciences, Key Laboratory of Otolaryngology and Head and Neck Surgery, Ministry of Education, Dongjiao Minxiang Street, Dongcheng District, Beijing 100730, China
    Cancer Genet Cytogenet 196:76-82. 2010
    ..We investigated CYP1A1, CYP1B1, CYP2E1, and CYP3A4 polymorphisms in 278 patients with laryngeal and hypopharyngeal SCC and 278 control subjects ..
  70. pmc Identification of four novel cytochrome P4501B1 mutations (p.I94X, p.H279D, p.Q340H, and p.K433K) in primary congenital glaucoma patients
    Mukesh Tanwar
    Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Mol Vis 15:2926-37. 2009
    ..Mutations in the cytochrome P4501B1 (CYP1B1) gene are a predominant cause of congenital glaucoma...
  71. pmc Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Carcinogenesis 32:203-9. 2011
    ..to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with ..
  72. doi CYP1B1-related anterior segment developmental anomalies novel mutations for infantile glaucoma and von Hippel's ulcer revisited
    Daniel Kelberman
    Ulverscroft Vision Research Group, University College London Institute of Child Health, London, and Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
    Ophthalmology 118:1865-73. 2011
    To determine the prevalence of CYP1B1 mutations in a cohort of patients with congenital corneal opacification (CCO), infantile glaucoma, or both and to describe a developmental CCO associated with CYP1B1 mutation that may explain von ..
  73. doi Current evidence on the relationship between CYP1B1 polymorphisms and lung cancer risk: a meta-analysis
    Wenhuan Xu
    Department of Oncology, The Fourth Affiliated Hospital of Suzhou University, Huihe Road 200, Wuxi 214000, China
    Mol Biol Rep 39:2821-9. 2012
    The association between single-nucleotide polymorphisms (SNPs) of the CYP1B1 gene and lung cancer risk is still ambiguous...
  74. doi Catechol-O-methyltransferase and cytochrome P-450 1B1 polymorphisms and endometrial cancer risk: a meta-analysis
    Yue Teng
    Center for Translational Medicine, The First Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an, People s Republic of China
    Int J Gynecol Cancer 23:422-30. 2013
    ..This meta-analysis aimed to assess the association between genetic polymorphisms involving estrogen metabolic enzymes and endometrial cancer risk...
  75. ncbi Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (Buphthalmos) in families linked to the GLC3A locus on chromosome 2p21
    I Stoilov
    Department of Surgery, University of Connecticut Health Center, Farmington, USA
    Hum Mol Genet 6:641-7. 1997
    ..In this study, heritable mutations of human cytochrome P4501B1 gene (CYP1B1) in affected individuals of five well-characterized families linked to the GLC3A locus are described...
  76. ncbi Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer
    L R Bailey
    Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232, USA
    Cancer Res 58:5038-41. 1998
    ..of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens is cytochrome P450 1B1 (CYP1B1), the predominant member of the CYP1 family expressed in normal breast tissue and breast cancer...
  77. ncbi Human CYP1B1 Leu432Val gene polymorphism: ethnic distribution in African-Americans, Caucasians and Chinese; oestradiol hydroxylase activity; and distribution in prostate cancer cases and controls
    Y M Tang
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Pharmacogenetics 10:761-6. 2000
    Cytochrome P4501B1 (CYP1B1) is involved in the activation of many carcinogens and in the metabolism of steroid hormones, including 17beta-oestradiol (E2) and testosterone...
  78. ncbi Association of CYP1B1 polymorphisms and breast cancer risk
    Immaculata De Vivo
    Department of Epidemiology, Harvard Center for Cancer Prevention, Harvard School of Public Health, and the Channing Laboratory, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 11:489-92. 2002
    b>Cytochrome P450 1B1 catalyzes the conversion of 17-beta-estradiol (E2) to thecatechol estrogen metabolites 2-OH-E2 and 4-OH-E2 that have been postulated to be involved in mammary carcinogenesis...
  79. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase (..
  80. pmc Phenotype of cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma
    Y Ohtake
    Department of Ophthalmology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Br J Ophthalmol 87:302-4. 2003
    To investigate the phenotypes associated with cytochrome P4501B1 gene (CYP1B1) mutations in Japanese patients with primary congenital glaucoma (PCG).
  81. pmc Founder mutations of CYP1B1 gene in patients with congenital glaucoma from the United States and Brazil
    D F Sena
    J Med Genet 41:e6. 2004
  82. ncbi Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms
    Jennifer Listgarten
    Cross Cancer Institute of the Alberta Cancer Board, Edmonton, Alberta, Canada
    Clin Cancer Res 10:2725-37. 2004
    ..synthase gene CYP11B2 at amino acid residue 386 Val/Ala (T/C) (rs4541); (b) the +4328C/G site of the aryl hydrocarbon hydroxylase CYP1B1 at amino acid residue 293 Leu/Val (C/G) (rs5292); and (c) the +4449C/T site of the transcription ..
  83. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  84. ncbi Cytochrome P4501B1 mutations cause only part of primary congenital glaucoma in Ecuador
    Stacey M Curry
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ophthalmic Genet 25:3-9. 2004
    To determine the role of cytochrome P450IBI (CYP1B1) mutations in causing primary congenital glaucoma (PCG) in a cohort of Native Americans from Quito, Ecuador.
  85. ncbi CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
    Toxicology 207:191-202. 2005
    ..We investigated the effect of CYP1A1 and CYP1B1 variant genotypes and haplotypes on CYP1A1 and CYP1B1 mRNA expression and ethoxyresorufin-O-deethylase (EROD) ..
  86. ncbi Gln48His is the prevalent myocilin mutation in primary open angle and primary congenital glaucoma phenotypes in India
    Subhabrata Chakrabarti
    Kallam Anji Reddy Molecular Genetics Laboratory, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    Mol Vis 11:111-3. 2005
    ....
  87. ncbi Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis
    Wanqing Wen
    Department of Medicine, Vanderbilt Ingram Cancer Center, Center for Health Service Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Epidemiol Biomarkers Prev 14:329-35. 2005
    b>Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are important estrogen-metabolizing enzymes and, thus, genetic polymorphisms of these enzymes may affect breast cancer risk...
  88. ncbi Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants
    Jennifer S Mammen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Pharmacogenet Genomics 15:183-8. 2005
    ..We examined whether cytochrome P450 1B1 (CYP1B1) was inhibited by coumarins, whether such inhibition was competitive, and whether inhibition varied ..
  89. ncbi Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 14:2173-7. 2005
    ..prostate cancer and multiple potentially functional polymorphisms in three genes involved in androgen metabolism: CYP1B1 (two single nucleotide polymorphisms: 355G/T and 4326C/G), prostate-specific antigen (PSA/KLK3 (three single ..
  90. ncbi A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio
    Valentina Paracchini
    Molecular and Genetic Epidemiology Unit, Fondazione Ospedale Policlinico IRCCS, Milan, Italy
    Clin Chem Lab Med 43:702-6. 2005
    ..b>CYP1B1 codes for an enzyme that catalyses the production of a 2- and 4-hydroxyl group in estrone and estradiol, while ..
  91. ncbi Primary role of CYP1B1 in Indian juvenile-onset POAG patients
    Moulinath Acharya
    Human Genetics and Genomics Division, Indian Institute of Chemical Biology, Kolkata, India
    Mol Vis 12:399-404. 2006
    b>CYP1B1, a member of the cytochrome P450 superfamily of enzymes, has been implicated in primary congenital glaucoma (PCG). Recent studies suggest a role of CYP1B1 in primary open-angle glaucoma (POAG) as a modifier locus...
  92. pmc Combinations of cytochrome P-450 genotypes and risk of early-onset lung cancer in Caucasians and African Americans: a population-based study
    M L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute at Wayne State University School of Medicine, Detroit, MI, United States
    Lung Cancer 55:255-62. 2007
    Polymorphisms in CYP1A1 and CYP1B1 genes in humans are associated with reduction of enzymatic activity towards several substrates, including those found in tobacco smoke...
  93. ncbi Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..14 single nucleotide polymorphisms in genes involved in hormone regulation or metabolism (AKR1C3, CYP1A1, CYP1B1, CYP3A4, ESR1, GNRH1, HSD173B, HSD3B2, SHBG, and SRD5A2) in 488 prostate cancer cases and 617 matched controls...
  94. ncbi Ovarian cancer risk and polymorphisms involved in estrogen catabolism
    Sarah K Holt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:481-9. 2007
    ..Subjects were interviewed and genotyped for CYP1A1 m1, m2, m3, and m4; CYP1B1 Arg(48)Gly, Ala(119)Ser, Val(432)Leu, and Asn(453)Ser; COMT Val(158)Met; UGT1A1 A(TA)nTAA; and SULT1A1 Arg(213)His ..
  95. ncbi Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk
    Wanqing Wen
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Cancer Epidemiol Biomarkers Prev 16:917-20. 2007
    b>Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) are important estrogen-metabolizing enzymes that may affect breast cancer risk...
  96. pmc Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients
    Arun Kumar
    Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India
    Mol Vis 13:667-76. 2007
    Mutations in the CYP1B1, MYOC, OPTN, and WDR36 genes result in glaucoma. Given its expression in the optic nerve, it is likely a mutation in the OPTC gene is also involved in initiating glaucoma...
  97. pmc Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk
    Lara Bethke
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK
    BMC Cancer 7:123. 2007
    ..Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones...
  98. ncbi Mutational screening of CYP1B1 in Turkish PCG families and functional analyses of newly detected mutations
    Sefayet Bagiyeva
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Mol Vis 13:1458-68. 2007
    ..To investigate the genetic basis of primary congenital glaucoma (PCG) in a collection of Turkish patients and to assess the pathogenicity of two novel alleles...
  99. ncbi Glaucoma-associated CYP1B1 mutations share similar haplotype backgrounds in POAG and PACG phenotypes
    Subhabrata Chakrabarti
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 48:5439-44. 2007
    To understand the involvement of the CYP1B1 gene in cases of primary open-angle (POAG) and primary angle-closure (PACG) glaucomas and obtain the haplotype background of these mutations.
  100. ncbi Genetic polymorphisms in cytochrome P4501B1 and susceptibility to head and neck cancer
    Arvind P Singh
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Mutat Res 639:11-9. 2008
    Cytochrome P4501B1 (CYP1B1), a polycyclic aromatic hydrocarbon (PAH) metabolizing CYP, is genetically polymorphic in humans and may be involved in the individual susceptibility to chemical-induced cancer...

Research Grants66

  1. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..These genes include CYP1A1, CYP1A2, CYP1B1, catechol 0-methyl transferase, sulfotransferase 1A1, and glutathione S-transferases (M1, P1, and T1)...
  2. MAMMARY ESTROGEN METABOLISM AND BREAST CANCER RISK
    Fritz Parl; Fiscal Year: 2004
    ..breast tissue and in breast tumors, catechol estrogens are produced by cytochromes P450 1A1 (CYP1A1) and 1B1 (CYP1B1) and are inactivated by catechol-O-methyltransferase (COMT)...
  3. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..The hypothesis of the proposed studies is that a polymorphism in CYP1B1 (CYP1B1*2) confers a more aggressive disease phenotype and a greater risk of recurrence of HNSCC...
  4. Bhagavatula Moorthy; Fiscal Year: 2015
    ..We propose the following Specific Aims. 1. To test the hypothesis mice lacking the gene for Cyp1b1 will be less susceptible to oxygen injury than wild type mice, and that the beneficial effects of Cyp1b1 deletion ..
  5. Yuichiro Tanaka; Fiscal Year: 2016
    ..contribute to the pathogenesis of RCC, (2) EMG SNPs lead to enzyme levels and activities that are increased for CYP1B1 and decreased for COMT in RCC, and (3) Over- expression of COMT or silencing of CYP1B1 inhibit RCC through cell ..
  6. Antagonism of the Ah Receptor in Controlling Breast Cancer Growth and Invasion
    Jennifer J Schlezinger; Fiscal Year: 2010
    ..3) Constitutively active AhR regulates the expression of multiple genes, including CYP1B1, CK21, and Slug, a master regulator of tumor invasion...
  7. Steven M Kawut; Fiscal Year: 2016
    ..Estradiol is metabolized by cytochrome P450 1B1 (CYP1B1) to metabolites which have both pro-angiogenic (16alpha-OHE{1}) and anti-angiogenic (2-OHE, 2-..
  8. CYP1B1: A Molecular Target for Chemoprevention of Lung Adenocarcinoma
    Margie L Clapper; Fiscal Year: 2013
    ..Exposure of mice to tobacco smoke induces the expression of cytochrome P450 1B1 (CYP1B1), an enzyme that converts both estrogen and constituents of tobacco smoke to carcinogenic ..
  9. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..In the absence of PPAR/ expression, increased expression of CYP1B1 and CYP1A1 and some phase II enzymes does not occur after application of PAHs...
  10. Alvaro Puga; Fiscal Year: 2015
    ..environmentally relevant doses of chromium(VI) have opposite effects on the BaP-mediated induction of CYP1A1, CYP1B1 and CYP1A2 cytochrome P450 genes, repress tumor suppressor gene expression and induce expression of pro-apoptotic ..
  11. CYP1B1, NF-kB , and Regulation of Angiogenesis
    TAMMY LYNN PALENSKI; Fiscal Year: 2012
    ..We recently showed that CYP1B1 plays an essential role in retinal vascular development and neovascularization during oxygen induced ischemic ..
  12. COLIN ROBERT JEFCOATE; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cytochrome P450 1b1 (Cyp1b1) participates in embryogenesis and is expressed in endothelia, fibroblasts and adipocytes...
  13. RNA from Brush Cytology to Identify Aggressive Squamous Cell Carcinoma
    Joel L Schwartz; Fiscal Year: 2013
    ..and have identified 2 specific markers for OSCC, in hamsters and humans, beta 2 microglobulin (B2M) and cytochrome p450 1B1 (CYP1B1)...
  14. Michael A Hauser; Fiscal Year: 2015
    ..Cytochrome P450 subfamily I polypeptide 1 (CYP1B1), is located within the GLC3A locus, and mutations in this gene account for approximately 10-20% of affected ..
  15. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..of human NAT1 or NAT2 variant alleles into Chinese hamster ovary cells transfected with human CYP1A1 or CYP1B1;determine the relative level of NAT1 and NAT2 expression in normal human mammary tissue as a function of genotype;..
  16. Kathleen E Malone; Fiscal Year: 2014
    ..are CYP2D6, CYP3A4, CYP3A5, but other important phase I and II enzymes include CYP2C9, CYP2C19, CYP2B6, CYP1B1, UGT2B7, UGT2B15, UGT1A4, UGT1A8, and UGT1A10...
  17. Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk Factors
    Yvette C Cozier; Fiscal Year: 2012
    ..involved in the synthesis of sex steroids (CYP17, CYP19), and the metabolism and detoxification of estrogen (COMT, CYP1B1, CYP1A1, ESR1), in relation to sarcoidosis risk...
  18. ENDOGENOUS CYP1B1 SUBSTRATES AS AHR LIGANDS
    Craig Marcus; Fiscal Year: 2003
    ..2) Endogenous substrates for CYP1B1 have regulatory roles in cellular metabolism, and one or more of these substrates function as ligands or ..
  19. PROTEIN KINASE C REGULATION OF P450 SYSTEM
    John Reiners; Fiscal Year: 2000
    ..Recent analyses of the expression of select members (Cyp1a1, Cyp1b1, Adhd4, and Nmo1) of the Ah battery in cells transfected with an oncogenic Ha-ras gene, or treated with 12-0-..
  20. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009
    ..to estrogens via androgens (HSD17B1, HSD17B2, HSD17B4, CYP19A1, and CYP17A1) and for estrogen catabolism (CYP1A1, CYP1B1, and COMT)...
  21. Narayan G Avadhani; Fiscal Year: 2016
    ..Additionally mt-CYP1B1 and CYP2C6 are induced in cardiomyocytes by hypoxia and myocardial ischemia...
  22. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..The induction of the microsomal monooxygenase, aryl hydrocarbon hydroxylase (AHH) activity, and other coordinately expressed enzymes, and the characteristic toxic responses of ..
  23. ENVIRONMENTAL POLLUTANTS--THE INTESTINE AND NUTRITION
    JAMES MANIS; Fiscal Year: 1980
    ..Intestinal and hepatic enzyme induction will be measured as benzo(a)pyrene hydroxylase (aryl hydrocarbon hydroxylase) concurrently in order to correlate the stimulatory effect on iron transport with the known enzyme-..
  24. EFFECT OF GINSENOSIDES ON CYTOCHROME P450
    Thomas Chang; Fiscal Year: 2001
    ..the proposed experiments will test the hypotheses that ginsenosides: 1) suppresses the inducibility of CYP1A1 and CYP1B1; 2) inhibits the catalytic activity of CYP1A1, CYP1A2, and CYP1B1; 3) inhibits the hepatic microsomal metabolism ..
  25. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Furthermore. retinal EC prepared from CYP1B1-/- mice are less migratory and fail to undergo capillary morphogenesis in Matrigel...
  26. BRENDA LYNN BOHNSACK; Fiscal Year: 2016
    ..PITX2 in ARS and CYP1B1 in PCG) regulate the ocular neural crest...
  27. SIMON W JOHN; Fiscal Year: 2016
    ..A number of reported human glaucoma loci have a dominant effect. Mutations in the human CYP1B1 gene predispose people to high IOP and glaucoma, a predisposition we have repeated in mice...
  28. Kafait U Malik; Fiscal Year: 2015
    ..grant period and is aimed to investigate the contribution of arachidonic acid (AA) metabolites generated via CYP1B1 and the underlying mechanism involved in Ang II-induced neointimal growth caused by vascular injury and ..
  29. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2009
    The main goal of this project is to investigate whether the cytochrome P4501A1 (CYP1A1) and cytochrome P4501B1 (CYP1B1) genes are risk factors for pathobiology of endometrial cancer...
  30. GENETIC SUSCEPTIBILITY TO HORMONAL CARCINOGENESIS
    ROLF PERSSON; Fiscal Year: 2000
    ..The proposed study aims to explore the hypothesis that functional polymorphisms of the gene for the CYP1B1 and COMT enzymes entail different activity levels, for metabolic activation of estradiol to reactive catechol ..
  31. Cancer prevention by indole-3-carbinol via modulation of the epigenome
    Abby D Benninghoff; Fiscal Year: 2010
    ..New evidence suggests that Cyp1b1 plays a critical role in the development of lymphoma in this animal model, and this gene is a target for ..
  32. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..g. grilled foods &cigarette smoke. Cytochromes P450 1A1 &1B1 (CYP1A1, CYP1B1) are responsible for the metabolism of numerous PAHs, the prototype of which is benzo[a]pyrene (BaP)...
  33. REGULATION OF POLYCYCLIC AROMATIC HYDROCARBON TOXICITY
    WILLIAM HOUSER; Fiscal Year: 1992
    ..on a detailed analysis of the mechanisms which regulate the expression of an important enzyme activity, aryl hydrocarbon hydroxylase (AHH)...
  34. MECHANISMS OF DMBA INDUCED BONE MARROW TOXICITY
    Charles Czuprynski; Fiscal Year: 2002
    ..The central hypothesis is that DMBA metabolism by CYP1B1 in bone marrow stromal cells results in release of metabolites that, directly or indirectly, cause apoptosis in ..
  35. A GENETIC APPROACH TO THE ROLE OF CYP1B1 IN PCG
    Bassem Bejjani; Fiscal Year: 2005
    ..We and others have shown that homozygous or compound heterozygous mutations in CYP1B1, the gene for cytochrome P4501B1, are the principal cause for PCG...
  36. ABNORMAL FETAL DEVELOPMENT DUE TO TOXIC EXPOSURE
    MRINAL SANYAL; Fiscal Year: 1991
    ..g., benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene). Benzo[a]pyrene hydroxylase (Aryl hydrocarbon hydroxylase) and other mixed function oxidase (MFO) enzyme activities are to be measured in human placental tissues ..
  37. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression strategy. Project #2 (Dr...
  38. GENES AND THE ESTROGEN EFFECT ON ENDOMETRIAL CANCER
    Giske Ursin; Fiscal Year: 2006
    ..We propose to evaluate a series of eight candidate genes (CYP17, CYP19, HSD17B1, ER, CYP1A1, CYP1B1, COMT andPR) in the estrogen biosynthesis, transactivation and metabolism pathways to determine if the effects of ..
  39. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..of genes involved in the biosynthesis and catabolism of estrogens (CYP11a, CYP17, EDH17beta2, CYP1A1, CYP1A2, CYP1B1, COMT), and those for the androgen receptor, estrogen receptor and IGF-I genes are related to the risk of breast ..
  40. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..2) To determine if genotype at the metabolic enzyme loci CYP1A1, CYP1B1, CYP17, CYP19, GSTM1, GSTP1, COMT, and NQO1 are associated with risk of adenocarcinoma of the lung in women...
  41. CYTOCHROME P450 GENES AND THEIR REGULATION
    Robert Tukey; Fiscal Year: 1999
    ..that when activated in the presence of ligand translocates to nucleus and couples with the nuclear aryl hydrocarbon hydroxylase nuclear translocator (ARNT) protein...
  42. Polycyclic Hydrocarbons and CYP1B1 in Breast Cancer
    Colin Jefcoate; Fiscal Year: 2005
    ..We have cloned cytochrome P4501B1 (CYP1B1) and have shown that CYP1B 1-null mice are resistant to several cancers, which are induced by PAHs in ..
  43. EMBRYOTOXICITY OF ENVIRONMENTAL CHEMICALS
    MONT JUCHAU; Fiscal Year: 2000
    ..Expression and regulation of expression of CYP1B1 in these tissues will be given high priority because P4501B1 mRNA has been detected in each of the three tissues of interest, because 1B1 seems likely to play an important ..
  44. CYP1A1 and CYP1B1 genes in race-related Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2007
    ..of this project is to investigate whether over-expression of cytochrome P450 1A1 (CYP1A1) and cytochrome P4501 B1 (CYP1B1) genes can be risk factors for race-related prostate cancer...
  45. Estrogen Pathway Genes and Association with Prostate Cancer Risk
    Janet Stanford; Fiscal Year: 2009
    ..that converts testosterone to estrogen, and the genes that encode estrogen catabolism enzymes (CYP1A1 and CYP1B1)...
  46. Effects of smoking on ERb and AHR pathway in human lung
    Radoslav Goldman; Fiscal Year: 2004
    ..We propose to examine expression-changes of the estrogen receptors alpha and beta, and induction of CYP1A1 and CYP1B1 by smoking in 87 human lung autopsy tissues as a possible early event in the lung carcinogenesis pathway...
  47. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..Recently, we have demonstrated a) overexpression of CYP1A1 enzyme, but not CYP1B1 enzyme, in epithelial OC specimens, b) increased transcription of CYP1A1 in epithelial OC cells when compared to ..
  48. DIOXIN TOXIC EQUIVALENCY FACTORS--BATTELLE MEMORIAL INST
    Milton Hejtmancik; Fiscal Year: 2000
    ..evaluations to be performed at 13, 30 and 52 weeks will include: Thyroid hormones; liver CYP1A1, CYP1A2 and CYP1B1, UDP-GT, porphyrins and retinol; lung CYP1A1 and CYP1B1; tissue concentration of test chemical(s) in liver, lung, ..
  49. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..Screening by RT-PCR for the level of mRNA expression of CYP1A1, CYP1B1 and CYP2E1 in peripheral blood mononuclear cells will also be performed as biomarkers of enzyme phenotypic ..
  50. PROSTATE CANCER IN MEXICANS AMERICANS & AFRICAN AMERICAN
    Sara Strom; Fiscal Year: 2003
    ..of genetic susceptibility and hormonal modulation, such as androgen receptor, 5-alpha-reductase type II, CYP17, CYP1B1, 3-beta-hydroxsteroid type II and vitamin D receptor, will be analyzed to determine if genotypic differences are ..
  51. Androgen Pathway Factors and Prostate Cancer
    John Witte; Fiscal Year: 2005
    ..3; 6) 3Beta-hydroxysteroid dehydrogenase II; 7) CYP1 la; 8) CYP19; 9) Insulin-like Growth Factor-I; and 10) CYP1B1 Specific Aim 2...
  52. CYP gene polymorphism and estrogen status in the elderly
    Reina Villareal; Fiscal Year: 2005
    ..The primary aims of this proposal are 1) to determine the prevalence of gene polymorphism of CYP1A1, CYP1B1, CYP1A2 and CYP3A4 among women and men of different ethnic groups 2) to determine the functional correlates of ..
  53. FUNCTIONAL AND GENETIC ANALYSES OF HUMAN CYP1B1
    Thomas Sutter; Fiscal Year: 2000
    ..integrated studies to elucidate the importance of the metabolic activation of procarcinogens by human cytochrome P4501B1 (CYP1B1), a potential susceptibility factor for chemical carcinogenesis...
  54. Molecular Epidemiology of Myelodysplastic Syndromes
    Sara Strom; Fiscal Year: 2002
    ..for the following markers associated with activation and detoxification of chemical carcinogens (CYP2E1, CYP1A1, CYP1B1, GSTT1, GSTM1, GSTP1, NQO1, and MPO)...
  55. PCBS & ESTROGENS ON PROINFLAMMATORY PHAGOCYTE FUNCTIONS
    Charles Rice; Fiscal Year: 2000
    ..3 classes of pollutants: nonylphenol, a xenoestrogen; PCB 126, a planar PCB that binds to the aryl hydrocarbon hydroxylase receptor (Ahr); and PCB 104, a non-planar PCB that does not bind to Ahr...
  56. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..result in a deficiency in the production, stability and function of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to ..
  57. CARCINOGEN SUPPRESSION OF KERATINOCYTE DIFFERENTIATION
    Robert Rice; Fiscal Year: 1990
    ..and related compounds will be undertaken to find whether this property is characteristic of inducers of aryl hydrocarbon hydroxylase. In addition, possible benzo(a)pyrene uncoupling of the differentiation program in normal human ..
  58. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 2010
    ..Specific aim 2 will address the hypotheses that induction of the human CYP1B1 gene requires different proteins and histone modifications than CYP1A1, and that this, at least in part, may ..
  59. Carcinogen Metabolism Enzyme Expression in Buccal Cells
    SIMON SPIVACK; Fiscal Year: 2003
    ..evaluation of gene expression of a panel of carcinogen metabolizing enzymes in buccal mucosa, including Ahr, ER, CYP1B1, CYP1A1, GSTM1, GSTM3, GSTP1, GSTT1, NQO1...
  60. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..polymorphisms in genes coding for enzymes that:1) metabolize nutrients and hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and ..
  61. ENVIRONMENTAL FACTORS IN THE INDUCTION OF CANCER
    LEILA DIAMOND; Fiscal Year: 1980
    ..in the induction of biological effects; (b) test the hypothesis that various types of inducers of aryl hydrocarbon hydroxylase (AHH) share specific but common binding sites and a common pathway leading to the induction of the ..
  62. Carcinogenicity of Estrogens
    DAVID SPINK; Fiscal Year: 2009
    ..The aryl hydrocarbon receptor (AhR) controls the expression of CYP1A1 and CYP1B1, enzymes that are known to catalyze the metabolism of numerous procarcinogens to ultimate carcinogens and ..
  63. Estrogen Bioactivation and Risk of Ovarian Cancer
    Thomas Sellers; Fiscal Year: 2005
    ..of DNA to detect known, functionally significant polymorphisms in genes for cytochrome P450 1A1 (CYP1A1), cytochrome P450 1B1 (CYP1B1), catechol 0-methyltransferase (COMT), sulfotransferase 1A1 (SULT1A1), glutathione S-transferase (..
  64. GENETICS OF AHH IN RELATION TO CANCER ETIOLOGY
    Beverly Paigen; Fiscal Year: 1980
    ..We have confirmed the report of others that aryl hydrocarbon hydroxylase (AHH) does vary in the population and that much of the variation is genetically determined...
  65. THE EFFECT OF CHEMICAL CARCINOGENS ON CELLS IN VITRO
    LEILA DIAMOND; Fiscal Year: 1980
    ..The levels of aryl hydrocarbon hydroxylase activity, the extent of hydrocarbon metabolism, the metabolite profiles, and the amounts and types of ..
  66. CARCINOGEN-METABOLIZING ENZYMES--ACTION IN VARIANT CELLS
    James Whitlock; Fiscal Year: 1990
    ..molecular level how the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces aryl hydrocarbon hydroxylase (AHH) activity in mammalian cells...