CYP1A2

Summary

Gene Symbol: CYP1A2
Description: cytochrome P450 family 1 subfamily A member 2
Alias: CP12, P3-450, P450(PA), cytochrome P450 1A2, CYPIA2, P450 form 4, aryl hydrocarbon hydroxylase, cholesterol 25-hydroxylase, cytochrome P(3)450, cytochrome P450 4, cytochrome P450, family 1, subfamily A, polypeptide 2, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2, cytochrome P450-P3, dioxin-inducible P3-450, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Species: human

Top Publications

  1. pmc Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
    M C Cornelis
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada M5S 3E2
    J Med Genet 41:758-62. 2004
  2. ncbi Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma
    A Prawan
    Department of Pharmacologygery, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, 40002, Thailand
    Eur J Cancer Prev 14:245-50. 2005
  3. ncbi Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary
    Istvan Kiss
    Department of Preventive Medicine, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 27:2931-7. 2007
  4. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
  5. ncbi The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
  6. ncbi Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1
    Celia P Martinez-Jimenez
    Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital La Fe, Avenida de Campanar, 21, 46009 Valencia, Spain
    Mol Pharmacol 70:1681-92. 2006
  7. doi The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms
    Marta Kot
    Polish Academy of Sciences, Institute of Pharmacology, Smetna 12, Pl 31 343 Krakow, Poland
    Biochem Pharmacol 76:543-51. 2008
  8. doi Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women
    Marianne Canonico
    Institut National de la Santé et de la Recherche Médicale INSERM Unit 780 U780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, Villejuif Cedex, F 94807 France
    J Clin Endocrinol Metab 93:3082-7. 2008
  9. pmc DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection
    S P Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA
    Am J Hum Genet 71:528-42. 2002
  10. ncbi Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation
    J Corchero
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenetics 11:1-6. 2001

Research Grants

  1. Interplay between metabolism and FXR activation in scoparone signaling
    Bingfang Yan; Fiscal Year: 2013
  2. CHRISTINE PERDAN CURRAN; Fiscal Year: 2014
  3. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION
    MARIA INES MORANO; Fiscal Year: 2013
  4. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
  5. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
  6. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2013
  7. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
  8. ACTIVITY OF P450/1A2 AND 3A4 AND BREAST CANCER RISK
    Wei Zheng; Fiscal Year: 1999
  9. Alvaro Puga; Fiscal Year: 2015
  10. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne L Backes; Fiscal Year: 2013

Detail Information

Publications206 found, 100 shown here

  1. pmc Genetic polymorphism of CYP1A2 increases the risk of myocardial infarction
    M C Cornelis
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada M5S 3E2
    J Med Genet 41:758-62. 2004
    ..In order to bind to DNA many mutagens require metabolic activation by cytochrome P450 (CYP) 1A1 or CYP1A2. The objective of this study was to determine the effects of CYP1A1 and CYP1A2 genotypes on risk of myocardial ..
  2. ncbi Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinoma
    A Prawan
    Department of Pharmacologygery, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, 40002, Thailand
    Eur J Cancer Prev 14:245-50. 2005
    Human CYP1A2 and arylamine N-acetyltransferases, which are encoded by the polymorphic CYP1A2 and NAT genes respectively, have been shown to have wide interindividual variations in metabolic capacity and may be potential modifiers of an ..
  3. ncbi Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary
    Istvan Kiss
    Department of Preventive Medicine, Faculty of Medicine, Pécs University of Sciences, Pecs, Hungary
    Anticancer Res 27:2931-7. 2007
    ....
  4. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population.
  5. ncbi The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..010. Variants in aryl hydrocarbon receptor (Ahr) (rs4986826), CYP1A1 (rs1799814) and CYP1A2 (rs2069514) were also, although less strongly, associated with changes in urine 1-OHPG concentrations...
  6. ncbi Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1
    Celia P Martinez-Jimenez
    Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital La Fe, Avenida de Campanar, 21, 46009 Valencia, Spain
    Mol Pharmacol 70:1681-92. 2006
    ..of PGC1alpha in human hepatoma cells caused a significant dose-dependent increase in CYP2C9, CYP1A1, and CYP1A2 and in the positive control CYP7A1...
  7. doi The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms
    Marta Kot
    Polish Academy of Sciences, Institute of Pharmacology, Smetna 12, Pl 31 343 Krakow, Poland
    Biochem Pharmacol 76:543-51. 2008
    ..The obtained results show that (1) apart from the 3-N-demethylation of caffeine - a CYP1A2 marker reaction and the main oxidation pathway of caffeine in man - 1-N-demethylation is also specifically ..
  8. doi Synergism between oral estrogen therapy and cytochrome P450 3A5*1 allele on the risk of venous thromboembolism among postmenopausal women
    Marianne Canonico
    Institut National de la Santé et de la Recherche Médicale INSERM Unit 780 U780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, Villejuif Cedex, F 94807 France
    J Clin Endocrinol Metab 93:3082-7. 2008
    ..This effect may be modulated by the expression of cytochromes P450 3A5 (CYP3A5) and 1A2 (CYP1A2) which are involved in the hepatic metabolism of estrogens.
  9. pmc DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection
    S P Wooding
    Department of Human Genetics, University of Utah, Salt Lake City, UT, 84112, USA
    Am J Hum Genet 71:528-42. 2002
    b>CYP1A2 is a cytochrome P450 gene that is involved in human physiological responses to a variety of drugs and toxins...
  10. ncbi Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation
    J Corchero
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenetics 11:1-6. 2001
    ..A human genomic clone from a BAC library, containing both CYP1A1 and CYP1A2 genes, was isolated and sequenced...
  11. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..controls (433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), sulfotransferase ..
  12. ncbi Population-based case-control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
    Ji Rong Long
    Department of Medicine and Vanderbilt Ingram Cancer Center, Vanderbilt University, 1161 21st Avenue South, Nashville, TN 37232, USA
    Pharmacogenet Genomics 16:237-43. 2006
    ..b>CYP1A2 is one of the major CYP1 enzymes that catalyse 2-hydroxylation of estrogen, a hormone that plays a critical role ..
  13. ncbi The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Canada
    Cancer Epidemiol Biomarkers Prev 16:912-6. 2007
    ..Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption ..
  14. ncbi Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking
    Kana Yoshida
    Faculty of Health Sciences, Kobe University Graduate School of Medicine, 7 10 2 Tomogaoka, Sumaku, Kobe 654 0142, Japan
    Asian Pac J Cancer Prev 8:438-44. 2007
    We investigated CYP1A1*2A, CYP1A1*2C, CYP1A2*1C, CYP1A2*1F, GSTM1 and NAT2 gene polymorphisms, involving enzymes which metabolize many carcinogens, with reference to colorectal cancer risk...
  15. pmc CYP1A1/2 haplotypes and lung cancer and assessment of confounding by population stratification
    Melinda C Aldrich
    Department of Medicine and Division of Neuroepidemiology, University of California, San Francisco, California, USA
    Cancer Res 69:2340-8. 2009
    ..These results suggest that a variant occurring within the CYP1A2 region may be conferring an increased risk of lung cancer in Latinos.
  16. doi Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women
    Suleeporn Sangrajrang
    Research Division, National Cancer Institute, Ratchathewi, Bangkok, Thailand
    Int J Cancer 125:837-43. 2009
    ..Forty single nucleotide polymorphisms (SNPs) in the CYP1A1, CYP1A2, CYP1B1, CYP17, CYP19, CYP2C9, CYP2C19, AhR, ESR1, PGR, ERRG, COMT, HSD17B1, HSD17B2, EPHX1 and NQO1 genes were ..
  17. pmc Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Hum Mol Genet 20:2071-7. 2011
    ..variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 (P = 5.4 · 10(-14)) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2.3 · 10(-11))...
  18. pmc CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies
    Hongge Wang
    Department of Epidemiology, College of Public Health, Hebei United University, Tangshan 063000, China
    BMC Cancer 12:528. 2012
    Genetic polymorphism (rs762551A>C) in gene encoding cytochrome P450 1A2 (CYP1A2) has been shown to influence the inducibility of CYP1A2 expression and thus might be associated with risk of several types of human cancer...
  19. doi The CYP1A2 -163C>A polymorphism is associated with clozapine-induced generalized tonic-clonic seizures in Brazilian schizophrenia patients
    Fabiana Barzotti Kohlrausch
    Departamento de Biologia Geral, Universidade Federal Fluminense, Niteroi, Brazil
    Psychiatry Res 209:242-5. 2013
    We evaluated two polymorphisms at CYP1A2 (*1C and *1F) in a sample of 108 European-derived patients with schizophrenia and their influence on the pro-convulsive effect of clozapine...
  20. pmc quantitative assessment of the influence of cytochrome P450 1A2 gene polymorphism and colorectal cancer risk
    Yuan Zhao
    Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, People s Republic of China
    PLoS ONE 8:e71481. 2013
    b>Cytochrome P450 1A2 (CYP1A2) encodes a member of the cytochrome P450 superfamily of enzymes, which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of ..
  21. ncbi Identification of novel polymorphisms in the 5' flanking region of CYP1A2, characterization of interethnic variability, and investigation of their functional significance
    K J Aitchison
    Clinical Neuropharmacology, Institute of Psychiatry, London, UK
    Pharmacogenetics 10:695-704. 2000
    ..However, studies aimed at identifying polymorphisms in CYPIA2 have not yet adequately accounted for this distribution pattern...
  22. ncbi Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2
    X M Han
    Pharmacogenetics Research Institute, Hunan Medical University, Changsha, China
    Pharmacogenetics 11:429-35. 2001
    Either G-2964 or A734 in the human CYP1A2 gene was confirmed to be associated with high inducible enzyme activity in smokers, but not in nonsmokers...
  23. ncbi Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine
    V Ozdemir
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Clin Psychopharmacol 21:603-7. 2001
    ..In theory, a very high CYP1A2 activity may lead to subtherapeutic concentrations and treatment resistance to clozapine...
  24. pmc Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2
    Xing Mei Han
    Pharmacogenetics Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan 410078, China
    Br J Clin Pharmacol 54:540-3. 2002
    To evaluate the effect of the CYP1A2*1C and CYP1A2*1F polymorphisms on the inducibility of CYP1A2 by omeprazole in healthy subjects.
  25. pmc Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 55:68-76. 2003
    Several single nucleotide polymorphisms (SNPs) of the cytochrome P450 enzyme 1A2 gene (CYP1A2) have been reported. Here, frequencies, linkage disequilibrium and phenotypic consequences of six SNPs are described.
  26. ncbi The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement
    Jan van der Weide
    Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk, The Netherlands
    Pharmacogenetics 13:169-72. 2003
    Clozapine is an atypical antipsychotic drug that is metabolized to a major extent by the cytochrome P450 enzyme CYP1A2. Smoking is a potent inducer of CYP1A2 enzyme activity, resulting in significant lower clozapine serum concentrations ..
  27. ncbi Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1
    Eleni Aklillu
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Mol Pharmacol 64:659-69. 2003
    b>CYP1A2 polymorphism has been well studied in white persons and Asians but not in Africans. We performed CYP1A2 genotype and phenotype analysis using caffeine in Ethiopians living in Ethiopia (n = 100) or in Sweden (n = 73)...
  28. ncbi Association of caffeine intake and CYP1A2 genotype with ovarian cancer
    Marc T Goodman
    Cancer Etiology Program, Cancer Research Center, University of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Nutr Cancer 46:23-9. 2003
    Coffee and caffeine consumption has been associated with ovarian cancer risk in several epidemiological studies. CYP1A2 is a key enzyme in the metabolism of coffee and in the activation of heterocyclic aromatic compounds that may be ..
  29. ncbi CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study
    Harald J J Moonen
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Food Chem Toxicol 42:869-78. 2004
    ..amine formed during ordinary cooking, and is subsequently metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2)...
  30. ncbi An investigation of mammographic density and gene variants in healthy women
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 112:683-8. 2004
    ..samples were analyzed for polymorphisms in the COMT (Val158Met), CYP1A1 (Ile462Val), CYP1B1 (Val432Leu), CYP1A2 (*1F) and CYP17 (T27C) genes using PCR-RFLP. Breast density was lower in Caucasians than in Asians...
  31. ncbi Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: I. Association of CYP1A2 gene polymorphism
    A K Tiwari
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    Pharmacogenomics J 5:60-9. 2005
    ..b>CYP1A2, an inducible gene of the cytochrome P450 family of genes, has been suggested to contribute to the metabolism of ..
  32. ncbi Association of genetic polymorphisms with serum estrogens measured multiple times during a 2-year period in premenopausal women
    Galina Lurie
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1521-7. 2005
    ..The DNA samples were analyzed by PCR/RFLP for the COMT Val158Met, CYP1A1*2A, CYP1A1*2B, CYP1A2*1F, CYP1B1 Val432Leu, and CYP17 T27C polymorphisms...
  33. ncbi The cytochrome P450 CYP1A2 genetic polymorphisms *1F and *1D do not affect clozapine clearance in a group of schizophrenic patients
    Jenny E Kootstra-Ros
    Department of Clinical Chemistry, St Jansdal Hospital, PO Box 138, 3840 AC Harderwijk, The Netherlands
    Ann Clin Biochem 42:216-9. 2005
    The atypical antipsychotic drug clozapine is metabolized by CYP1A2. The activity of CYP1A2 is highly variable and is among others dependent on smoking habits...
  34. ncbi Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Suite 407, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Cancer Epidemiol Biomarkers Prev 14:1998-2003. 2005
    ..breast cancer and sequence variants in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a ..
  35. ncbi The G-113A polymorphism in CYP1A2 affects the caffeine metabolic ratio in a Chinese population
    Xiaoping Chen
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Beijing, China
    Clin Pharmacol Ther 78:249-59. 2005
    This study was designed to better understand genetic variation in the cytochrome P450 (CYP) gene CYP1A2 and its impact on CYP1A2 activity in Chinese subjects.
  36. ncbi Influence of the genetic polymorphism in the 5'-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers
    Sofia Pavanello
    Occupational Health Section, Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, Padova 35128, Italy
    Mutat Res 587:59-66. 2005
    ..The influence of three polymorphisms of the cytochrome P450 1A2 gene (CYP1A2) (-3860 G-->A (allele *1C), -2467 T-->delT (allele *1D), -163C-->A (allele *1F)), ..
  37. ncbi Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy
    Keiji Takata
    Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Science, Kumamoto University, and Department of Medicine, Kumamoto City Hospital, Japan
    Eur J Clin Pharmacol 62:23-8. 2006
    To clarify the association between the cytochrome P450 (CYP) 1A2 genotype with the CYP1A2 phenotype and to search for the CYP1A2*1K haplotype, which has been shown to decrease CYP1A2 inducibility and/or other functional polymorphisms in ..
  38. ncbi [A case-control study on the association between genetic polymorphisms of metabolic enzymes and the risk of colorectal cancer]
    Kun Chen
    Departent of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310031, China
    Zhonghua Liu Xing Bing Xue Za Zhi 26:659-64. 2005
    ..To investigate the association between metabolic enzymes polymorphisms and the risk of colorectal cancer(CRC)...
  39. ncbi A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
    Rika Ueda
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki aoba 6 3, Aoba ku, Sendai 980 8578, Japan
    Mol Pharmacol 69:1924-30. 2006
    The human CYP1A1 and CYP1A2 genes on chromosome 15 are orientated head-to-head and are separated by a 23-kilobase (kb) intergenic spacer region...
  40. ncbi Coffee, CYP1A2 genotype, and risk of myocardial infarction
    Marilyn C Cornelis
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    JAMA 295:1135-41. 2006
    ..Coffee is a major source of caffeine, which is metabolized by the polymorphic cytochrome P450 1A2 (CYP1A2) enzyme...
  41. ncbi Effects of genetic polymorphisms of MDR1, FMO3 and CYP1A2 on susceptibility to colorectal cancer in Koreans
    Sun Young Bae
    Department of Surgery, Inha Institute of Research for Medical Sciences, College of Medicine, Inha University, Incheon 410 712, Korea
    Cancer Sci 97:774-9. 2006
    ..to colorectal cancer (CRC) of genetic polymorphisms in P-glycoprotein (PGP) and the metabolic enzymes cytochrome P450 1A2 (CYP1A2) and flavin-containing monooxygenase 3 (FMO3)...
  42. ncbi Genetic susceptibility to Tardive Dyskinesia in chronic schizophrenia subjects: V. Association of CYP1A2 1545 C>T polymorphism
    A K Tiwari
    Department of Genetics, University of Delhi South Campus, New Delhi, India
    Pharmacogenomics J 7:305-11. 2007
    ..b>CYP1A2 is involved in the metabolism of atypical antipsychotic drugs such as clozapine and olanzapine...
  43. ncbi Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes
    Federica Gemignani
    Genetics, Department of Biology, University of Pisa, Pisa, Italy
    Carcinogenesis 28:1287-93. 2007
    ..Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 ..
  44. pmc Breast density and polymorphisms in genes coding for CYP1A2 and COMT: the Multiethnic Cohort
    Yumie Takata
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI, USA
    BMC Cancer 7:30. 2007
    ..This cross-sectional analysis examined the relation between mammographic density and the CYP1A2*1F and COMT Val58 Met polymorphisms among 332 breast cancer cases and 254 controls in the Hawaii component of the ..
  45. ncbi Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
    Roza Ghotbi
    Division of Clinical Pharmacology, Karolinska University Hospital Huddinge, Karolinska Institutet, C1 68, 141 86, Stockholm, Sweden
    Eur J Clin Pharmacol 63:537-46. 2007
    To investigate the CYP1A2 genotype-phenotype relationship and to compare CYP1A2 genetic polymorphisms and enzyme activity in terms of the effect of smoking and oral contraceptive (OC) use in Swedes and Koreans.
  46. ncbi NAT2 and CYP1A2 polymorphisms and lung cancer risk in relation to smoking status
    Yasunori Osawa
    Kobe University Graduate School of Medicine, Tomogaoka, Sumaku, Kobe 654 0142, Japan
    Asian Pac J Cancer Prev 8:103-8. 2007
    ..and the gene polymorphisms of the drug metabolizing enzymes, containing cytochrome P450 1A1 (CYP1A1), cytochrome P450 1A2 (CYP1A2), glutathione S-transferase class mu (GSTM1), and N-acetyltransferase 2 (NAT2)...
  47. ncbi Impact of CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients
    Kristina I Melkersson
    Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
    J Clin Psychiatry 68:697-704. 2007
    ..The genetically polymorphic cytochromes P450 CYP1A2 and CYP2D6 catalyze the metabolism of clozapine...
  48. pmc Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk
    Lara Bethke
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK
    BMC Cancer 7:123. 2007
    ..Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones...
  49. ncbi Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutritional Sciences, University of Toronto, Canada
    Am J Clin Nutr 86:240-4. 2007
    ..Caffeine is the most widely consumed stimulant in the world, and individual differences in response to its stimulating effects may explain some of the variability in caffeine consumption within a population...
  50. ncbi Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption
    Sebastien Kury
    Laboratoire d Etude de l ADN, Faculté de Médecine de Nantes, 1 rue Gaston Veil, 44035 Nantes Cedex, France
    Cancer Epidemiol Biomarkers Prev 16:1460-7. 2007
    ..163A>C and c.1548T>C in CYP1A2, g.-1293G>C and g.-1053C>T in CYP2E1, c.1294C>G in CYP1B1, and c.430C>T in CYP2C9)...
  51. doi Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms
    Arzu Gunes
    Uppsala University, Department of Medical Sciences, Clinical Pharmacology, SE 75185 Uppsala, Sweden
    Pharmacogenomics 9:625-37. 2008
    b>CYP1A2 is involved in the metabolism of several widely used drugs and endogenous compounds, and in the activation of procarcinogens. Both genetic and environmental factors influence the activity of this enzyme...
  52. doi CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population
    Ertan Altayli
    Department of Medical Biology and Genetics, Faculty of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey
    Int Urol Nephrol 41:259-66. 2009
    ..The objective of this study was to investigate the relationship between bladder tumor and variants of cytochrome p450 1A2 (CYP1A2) 734 C --> A, cytochrome p450 2D6 (CYP2D6) 1934 G --> A, glutathione S-transferase M1, (GSTM1 ..
  53. ncbi CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas
    Mona Saebø
    Telemark University College, Faculty of Arts and Sciences, Bø i Telemark, Norway
    Anticancer Res 28:2289-95. 2008
    ..Genetic polymorphisms in metabolizing enzymes may modify the association of environmental exposure on colorectal cancer (CRC) and adenoma risk...
  54. pmc Coffee intake and CYP1A2*1F genotype predict breast volume in young women: implications for breast cancer
    H Jernstrom
    Department of Oncology, Clinical Sciences, Lund University, Barngatan 2B, SE 221 85 Lund, Sweden
    Br J Cancer 99:1534-8. 2008
    As breast volume may be associated with heart cancer risk, we studied the relationship between breast volume, CYP1A2*1F and coffee intake...
  55. pmc Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk
    Michelle Cotterchio
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
    Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008
    ....
  56. doi Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer
    Chih Ching Yeh
    Department of Health Risk Management, College of Public Health, China Medical University, Taichung, Taiwan
    Dis Colon Rectum 52:104-11. 2009
    ..A hospital-based study was designed to investigate the association between colorectal cancer and cytochrome P-450 1A2, N-acetyltransferase 1, and N-acetyltransferase 2, with the interaction of meat consumption...
  57. doi CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population
    Fatma B'chir
    Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics, Sousse 4002, Tunisia
    Life Sci 84:779-84. 2009
    In this study, the effects of four single nucleotide polymorphisms (SNPs), -3860G>A, -2467delT, -739T>G and -163C>A, of CYP1A2 gene on lung cancer were evaluated in Tunisian population.
  58. doi Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population
    Arzu Gunes
    Department of Medical Sciences, Clinical Pharmacology, Uppsala University, Uppsala, Sweden
    Pharmacogenomics 10:769-78. 2009
    To study the variation in CYP1A2 activity in relation to smoking, gender, age and CYP1A2 polymorphisms.
  59. doi CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
    Paolo Palatini
    Clinica Medica 4, University of Padova, Via Giustiniani, 2 35128 Padova, Italy
    J Hypertens 27:1594-601. 2009
    The longitudinal relationship between coffee use and hypertension is still controversial. Cytochrome P450 1A2 (CYP1A2) is the main responsible enzyme for the metabolism of caffeine...
  60. doi Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of colorectal cancer: a hospital-based case-control study in Japan
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Scand J Gastroenterol 44:952-9. 2009
    ..A further objective was to investigate the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on colorectal cancer.
  61. doi Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment
    Cristina Rodriguez-Antona
    Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Hum Genet 127:1-17. 2010
    ..We conclude that the CYP polymorphism does not predict cancer susceptibility to any large extent but that this polymorphism might be an important factor for optimal cancer therapy using selected anticancer agents...
  62. doi Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
    Shu Feng Zhou
    Discpline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria 3083, Australia
    Drug Metab Rev 42:268-354. 2010
    Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of clinical drugs (e.g., clozapine, tacrine, tizanidine, and theophylline; n > 110), a number of procarcinogens (e.g...
  63. doi Association between dietary heterocyclic amine levels, genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 and risk of stomach cancer: a hospital-based case-control study in Japan
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Gastric Cancer 12:198-205. 2009
    ..We conducted a case-control study to investigate the association between HCA intake and stomach cancer risk. We also investigated the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on stomach cancer.
  64. pmc Frequencies of genetic polymorphisms related to triptans metabolism in chronic migraine
    Giovanna Gentile
    Department of Biochemical Sciences, Advanced Molecular Diagnostic Unit, 2nd School of Medicine, Sapienza University, Sant Andrea Hospital, Via di Grottarossa 1035, Rome, Italy
    J Headache Pain 11:151-6. 2010
    ..for polymorphisms in the genes coding for monoamine oxidase A, g-protein beta 3 and the cytochromes CYP3A4 and CYP1A2. Alleles and genotypes distributions were compared with known frequencies of healthy Caucasian populations...
  65. doi Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk
    Emma L Northwood
    Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital
    Pharmacogenet Genomics 20:315-26. 2010
    ....
  66. pmc Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia
    Hansong Wang
    Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Carcinogenesis 32:203-9. 2011
    ..Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their ..
  67. pmc Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study
    Li Tao
    Masonic Cancer Center, University of Minnesota, MN, USA
    Int J Cancer 130:1174-83. 2012
    b>Cytochrome P450 1A2 (CYP1A2) is hypothesized to catalyze the activation of arylamines, known human bladder carcinogens present in cigarette smoke...
  68. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR ..
  69. doi Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer
    Ekaterina P Khvostova
    Department of Molecular Mechanisms of Carcinogenesis, Institute of Molecular Biology and Biophysics, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia
    Genet Test Mol Biomarkers 16:167-73. 2012
    Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (aromatase), and the II-phase enzyme sulfotransferase 1A1 (SULT1A1) genes are associated with a high risk of hormone-dependent cancers...
  70. doi Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men
    Arvind P Singh
    Developmental Toxicology Division, Environmental Epidemiology Division, Indian Institute of Toxicology Research Council of Scientific and Industrial Research, M G Marg, Lucknow, India
    Cancer Biomark 8:351-9. 2010
    ..study was carried out to investigate the association of functionally important polymorphisms of cytochrome P450 1A2 (CYP1A2) involved in the metabolic activation of tobacco derived procarcinogens with squamous cell ..
  71. doi Role of CYP1A2 polymorphisms on lung cancer risk in a prospective study
    Sofia Pavanello
    Occupational Health Section, Department of Cardiological, Thoracic and Vascular Sciences, Universita di Padova, Italy
    Cancer Genet 205:278-84. 2012
    Cytochrome P4501A2 (CYP1A2) is a key enzyme for lung carcinogen activation and lung inflammation...
  72. pmc Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
    M A Butler
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079
    Proc Natl Acad Sci U S A 86:7696-700. 1989
    ....
  73. pmc The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women
    Anna Nordmark
    Department of Medical Laboratory Science and Technology, Division of Clinical Pharmacology, Karolinska Institutet, C 168, Huddinge University Hospital, SE 141 86 Stockholm, Sweden
    Br J Clin Pharmacol 54:504-10. 2002
    To investigate the influence of the CYP1A2*1F mutation on CYP1A2 activity in smoking and nonsmoking pregnant women.
  74. ncbi Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
    Manuela Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033 0800, USA
    Carcinogenesis 24:483-9. 2003
    ..effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye-bladder cancer association, among female participants (159 cases, 164 controls) of the ..
  75. ncbi Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer
    Hiromasa Tsukino
    Department of Public Health, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, 889 1692, Japan
    J Cancer Res Clin Oncol 130:99-106. 2004
    ..Recently, several polymorphisms of CYP1A2, SULT1A1, and NAT2 that affect their activities have been reported.
  76. ncbi CYP1A2 phenotype and genotype in a population from the Carboniferous Region of Coahuila, Mexico
    Fabiola Castorena-Torres
    Sección Externa de Toxicología, Centro de Investigacion y de Estudios Avanzados del IPN, Av Instituto Politecnico Nacional 2508, Col San Pedro Zacatenco, Mexico City C P 07360, Mexico
    Toxicol Lett 156:331-9. 2005
    b>CYP1A2 regulation by polycyclic aromatic hydrocarbons (PAHs) exposure and polymorphism was investigated in 46 male volunteers from the Carboniferous Region in northern Coahuila, Mexico...
  77. pmc Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 426, Houston, TX 77030, USA
    Carcinogenesis 27:103-11. 2006
    ..e. cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 1 and 2 (NAT1 and NAT2), in a hospital-based case-control study of 365 ..
  78. ncbi The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans
    Harald Moonen
    Department of Health Risk Analysis and Toxicology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cancer Lett 229:25-31. 2005
    ..heterocyclic aromatic amines (HCA) herein, which are metabolically activated by the enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase 2 (NAT2)...
  79. ncbi Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing
    Carsten Skarke
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur J Clin Pharmacol 61:887-92. 2005
    To develop a rapid and reliable screening method for identifying the relevant cytochrome P450 (CYP) 1A2 alleles CYP1A2*1D (-2467Tdel), *1F (-163A>C), and *1K (-739T>G, -729C>T, -163A>C) that are in linkage disequilibrium with ..
  80. doi Coffee consumption and CYP1A2*1F genotype modify age at breast cancer diagnosis and estrogen receptor status
    Erika Bågeman
    Department of Oncology, Clinical Sciences, Lund University, Lund, Sweden
    Cancer Epidemiol Biomarkers Prev 17:895-901. 2008
    b>CYP1A2 plays a key role in the metabolism of both estrogen and coffee. Women with higher coffee intake and the CYP1A2*1F A/A genotype have a ratio of high 2-hydroxyestrone (2-OHE1) to 16alpha-OHE1...
  81. pmc Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancer
    Hideo Suzuki
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 29:1184-91. 2008
    ..the risk of pancreatic cancer (PC), we investigated the effect of single-nucleotide polymorphisms (SNPs) of the CYP1A2, NAT1, NAT2 and SULT1A1 gene on modification of the risk of PC in a hospital-based study of 755 patients with ..
  82. ncbi Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development
    Bo Wang
    Discipline of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, Victoria, Australia
    Curr Med Chem 16:4066-218. 2009
    Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver ( approximately 13%) and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a molecular mass of 58,294 Dal...
  83. ncbi In vitro and in vivo evaluations of cytochrome P450 1A2 interactions with duloxetine
    Evelyn D Lobo
    Eli Lilly and Company, Indianapolis, Indiana, USA
    Clin Pharmacokinet 47:191-202. 2008
    ..To determine whether duloxetine is a substrate, inhibitor or inducer of cytochrome P450 (CYP) 1A2 enzyme, using in vitro and in vivo studies in humans...
  84. ncbi Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum
    Michael M Iba
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy and the Environmental and Occupational Health Sciences Institute, Rutgers University, 170 Frelinghuysen Road, NJ 08854, Piscataway, USA
    Arch Toxicol 77:547-54. 2003
    ..In the cerebral cortex, cytochrome P450 1A1 (CYP1A1) protein was more abundant than cytochrome P450 1A2 (CYP1A2) protein...
  85. ncbi Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2
    Shizuo Narimatsu
    Laboratory of Health Chemistry, Faculty of Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama 700 8530, Japan
    Chem Biol Interact 152:1-12. 2005
    A cDNA encoding a novel cytochrome P450 1A2 (CYP1A2) was cloned from the liver of an adult female Japanese monkey...
  86. ncbi Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo
    John Teilmann Larsen
    Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Basic Clin Pharmacol Toxicol 97:141-8. 2005
    b>Cytochrome P450 1A2 (CYP1A2) is a major drug-metabolising enzyme. Polycyclic aromatic hydrocarbons, present in high concentrations in tobacco smoke and charcoal-broiled meat, are known to induce CYP1A2...
  87. ncbi Inhibition of the human liver microsomal and human cytochrome P450 1A2 and 3A4 metabolism of estradiol by deployment-related and other chemicals
    Khawja A Usmani
    Arena Pharmaceuticals, Inc, San Diego, USA
    Drug Metab Dispos 34:1606-14. 2006
    ..It has previously been shown that E2 is predominantly metabolized in humans by CYP1A2 and CYP3A4 with 2-hydroxyestradiol (2-OHE2) the major metabolite...
  88. ncbi Use of heterologously expressed human cytochrome P450 1A2 to predict tacrine-fluvoxamine drug interaction in man
    L Becquemont
    Clinical Pharmacology Unit, Saint Antoine University Hospital, Paris, France
    Pharmacogenetics 8:101-8. 1998
    The aim of the present study was to evaluate the use of recombinant human cytochrome P-450 1A2 (rH-CYP1A2) in studies performed in vitro in order to predict metabolic drug-drug interactions occurring in man...
  89. doi Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate
    Kenzi Nakano
    Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, N18 W9, Kita ku, Sapporo, 060 0818, Japan
    Biometals 22:345-51. 2009
    Accumulating evidence, including experiments using cytochrome P450 1a2 (Cyp1a2) gene knock-out mice (Cyp1a2(-/-)), indicates that the development of chemically induced porphyria requires the expression of CYP1A2...
  90. ncbi Interaction of upstream stimulatory factor proteins with an E-box located within the human CYP1A2 5'-flanking gene contributes to basal transcriptional gene activation
    George V Pickwell
    Department of Medicine, Section of Medical Toxicology, B146, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Biochem Pharmacol 65:1087-96. 2003
    ..In most, its expression is restricted to the liver. Sequence analysis of the human CYP1A2 5'-flanking region from +3 to -3201 identified six E-box motifs within the 3-methylcholanthrene (MC) enhancer ..
  91. pmc Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
    Shu Feng Zhou
    Discipline of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Bundoora, Victoria, Australia
    AAPS J 11:481-94. 2009
    Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g...
  92. doi Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2
    A Messina
    Istituto di Fisiologia Clinica, Area della Ricerca CNR, Pisa, Italy
    Xenobiotica 38:1453-70. 2008
    ..a good catalytic activity towards caffeine, acetanilide, and methoxyresorufin, all known markers of mammalian CYP1A2. Using 3'- and 5'-rapid amplification of coding DNA (cDNA) ends (RACE), we amplified from the liver RNA of control ..
  93. ncbi Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction
    Klaus Abraham
    Department of Pediatric Pneumology and Immunology, Institute of Clinical Pharmacology, Charite, Humboldt University Berlin, Augustenburger Platz 1, 13 153 Berlin, Germany
    Clin Pharmacol Ther 72:163-74. 2002
    The correct in vivo quantification of aryl hydrocarbon receptor-mediated induction of cytochrome P450 1A2 (CYP1A2) in humans is a long-standing question...
  94. ncbi A distribution study of CYP1A2 phenotypes among smokers and non-smokers in a cohort of healthy Caucasian volunteers
    D Schrenk
    Institute of Toxicology, University of Tubingen, Germany
    Eur J Clin Pharmacol 53:361-7. 1998
    ....
  95. ncbi Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine
    Juan Antonio Carrillo
    Department of Pharmacology and Psychiatry, Extremadura University School of Medicine, Badajoz, Spain
    J Clin Psychopharmacol 23:119-27. 2003
    ..Caffeine and debrisoquine were used as measures of CYP1A2 and CYP2D6, respectively...
  96. ncbi Insights into the structure, function, and regulation of human cytochrome P450 1A2
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Victoria 3083, Australia
    Curr Drug Metab 10:713-29. 2009
    b>CYP1A2 is one of the major CYPs in human liver ( approximately 13%) and metabolises a variety of clinically important drugs, such as clozapine, lidocaine, theophylline, tacrine, and leflunomide...
  97. pmc Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2
    Qingbiao Huang
    Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Drug Metab Dispos 38:1039-45. 2010
    Human CYP1A2 is an important drug-metabolizing enzyme, similar in sequence to CYP1A1 but with distinct substrate specificity. We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins...
  98. pmc Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism
    H C Liang
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 93:1671-6. 1996
    b>Cytochrome P450 1A2 (CYP1A2) is a predominantly hepatic enzyme known to be important in the metabolism of numerous foreign chemicals of pharmacologic, toxicologic, and carcinogenic significance...
  99. ncbi Heterologous expression and characterization of wild-type human cytochrome P450 1A2 without conventional N-terminal modification in Escherichia coli
    Dong Hyun Kim
    School of Biological Sciences and Technology and Hormone Research Center, Chonnam National University, 300 Yongbong Dong, Buk Gu, Gwangju 500 757, Republic of Korea
    Protein Expr Purif 57:188-200. 2008
    In this study, wild-type human CYP1A2 without the conventional N-terminal modification (second codon GCT) or the truncation of the N-terminal hydrophobic region was functionally expressed in Escherichia coli...
  100. ncbi Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron
    Nadia Gorman
    VA Medical Center, White River Junction, VT 05009, USA
    Hepatology 35:912-21. 2002
    ..Here we investigate the development of uroporphyria as a function of CYP1A2 and iron levels in the liver of mice having a common C57BL/6 genetic background...

Research Grants64

  1. Interplay between metabolism and FXR activation in scoparone signaling
    Bingfang Yan; Fiscal Year: 2013
    ..In contrast, the enhancement was significantly increased in cells transfected with cytochrome P450 1A2 (CYP1A2), a drug-metabolizing enzyme...
  2. CHRISTINE PERDAN CURRAN; Fiscal Year: 2014
    ..affect susceptibility to PCB-induced developmental neurotoxicity: the aryl hydrocarbon receptor (AHR) and cytochrome P450 1A2 (CYP1A2)...
  3. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION
    MARIA INES MORANO; Fiscal Year: 2013
    ..According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated in at least an in vitro system...
  4. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  5. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..DNA samples will be prepared from patients and controls and genotyped for specific CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 polymorphisms, and the results analyzed as related to phenotype (e.g...
  6. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2013
    ..will be delivered prematurethe hypothesis that newborn mice lacking the genes for CYP1A1 or the liver- specific CYP1A2 will be more susceptible to acute and long-term lung injury induced by oxygen...
  7. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..We previously were successful in introducing human CYP1A2 and CYP1A1 into yeast and activating a variety of carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene ..
  8. ACTIVITY OF P450/1A2 AND 3A4 AND BREAST CANCER RISK
    Wei Zheng; Fiscal Year: 1999
    ..Cytochrome P450-1A2 (CYP1A2) and 3A4(CYP3A4) are two of the major enzymes in estrogen hydroxylation, forming biologically distinct metabolites:..
  9. Alvaro Puga; Fiscal Year: 2015
    ..relevant doses of chromium(VI) have opposite effects on the BaP-mediated induction of CYP1A1, CYP1B1 and CYP1A2 cytochrome P450 genes, repress tumor suppressor gene expression and induce expression of pro-apoptotic genes, ..
  10. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne L Backes; Fiscal Year: 2013
    ..is responsible for both aliphatic and aromatic hydroxylation of the aromatic hydrocarbons, with several forms, CYP1A2, CYP2B4, and CYP2E1, being implicated in hydrocarbon metabolism...
  11. Bhagavatula Moorthy; Fiscal Year: 2015
    ..The central hypothesis of this application is that CYP1A1 and CYP1A2 enzymes play reciprocal roles in PAH-mediated carcinogenesis, and that a CYP1A2-dependent MC metabolite(s) ..
  12. Hyunyoung Jeong; Fiscal Year: 2015
    ..elimination of cytochrome P450 (CYP)2A6, -2C9, -2D6, or -3A4 substrate drugs, while decreasing elimination of CYP1A2 or -2C19 substrates...
  13. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..Alkanes and their metabolites are metabolized rapidly by high risk cytochrome P450 phenotypes (e.g., CYP1A1, CYP1A2 and CYP2E1) whose activity is induced by polycyclic aromatic hydrocarbons in tobacco smoke...
  14. EFFECT OF GINSENOSIDES ON CYTOCHROME P450
    Thomas Chang; Fiscal Year: 2001
    ..ginsenosides: 1) suppresses the inducibility of CYP1A1 and CYP1B1; 2) inhibits the catalytic activity of CYP1A1, CYP1A2, and CYP1B1; 3) inhibits the hepatic microsomal metabolism of drugs catalyzed by CYP1A2; and 4) inhibits the ..
  15. Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..3) To test the hypothesis that mice lacking the gene for CYP1A1, CYP1A2, or both genes (CYP1A1/1A2 double knockouts) will be more susceptible to hyperoxia-induced lung injury than ..
  16. Pharmacogenomics of Human P450 Oxidoreductase
    Walter L Miller; Fiscal Year: 2012
    ..show that A503V has decreased activities in assays based on cytochrome c and P450c17, but not in assays based on CYP1A2 and CYP2C19...
  17. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
    ..We propose a randomized crossover feeding trial of broccoli and green cabbage supplementation on measures of CYP1A2, GST-[unreadable], and UGT1A1, and ITC excretion under defined-diet conditions...
  18. TeamChip for High-throughput, Predictive Human Metabolism and Toxicology
    Moo Yeal Lee; Fiscal Year: 2010
    ..g., CYP450 isoforms including CYP1A2 and CYP3A4) and demonstrate gene transfection on monolayers of THLE-2 and Beas-2B cells using fluorogenic ..
  19. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..The induction of the microsomal monooxygenase, aryl hydrocarbon hydroxylase (AHH) activity, and other coordinately expressed enzymes, and the characteristic toxic responses of ..
  20. ENVIRONMENTAL POLLUTANTS--THE INTESTINE AND NUTRITION
    JAMES MANIS; Fiscal Year: 1980
    ..Intestinal and hepatic enzyme induction will be measured as benzo(a)pyrene hydroxylase (aryl hydrocarbon hydroxylase) concurrently in order to correlate the stimulatory effect on iron transport with the known enzyme-..
  21. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    ..The CYP isoforms to be studied, CYP3A4, CYP2D6 and CYP1A2, are involved in the metabolism of >80% of marketed prescription and over the counter medications...
  22. AGING AND CYP-MEDIATED HERB-DRUG INTERACTIONS
    Bill Gurley; Fiscal Year: 1999
    ..John's wort modulate specific hepatic CYP activities (i.e. CYP1A2, CYP2D6, CYP2E1, and CYP3A4); and (2) whether aging potentiates the risk of CYP-mediated herb-drug interactions...
  23. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..e., carrot-family) vegetable supplementation on CYP1A2 activity, serum glutathione S- transferase-alpha (GSTalpha), and urinary isothiocyanate excretion under defined-..
  24. ALLEN BERNARD REITZ; Fiscal Year: 2014
    ..FC-311 is not subject to the limiting Cyp1A2 metabolism and large patient-to-patient variability of exposure that riluzole is, and has a ~3X longer high-life, ..
  25. Drug Metabolism and Chronic Liver Disease
    Robert Branch; Fiscal Year: 2005
    ..Part 1: A cocktail to include: caffeine (CYP1A2), flurbiprofen (CYP2C9), mephenytoin (CYP2C19), debrisoquine (CYP2D6), chlorzoxazone (CYP2E1) and dapsone (..
  26. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..Theophylline will be used for CYP1A2. Assessments of oxidative stress (urinary F2-isoprostanes, monocyte NFKB) and active fibrinogenesis (TGFbeta-1, N-..
  27. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..CYP 1 A, one of the CYP subfamilies in vertebrates consisting of two members, CYP1A1 and CYP1A2, catalyzes the metabolism of such environmental chemicals as polycyclic aromatic hydrocarbons and arylamines as ..
  28. REPRODUCTIVE/CONTRACEPTIVE RISK FACTORS & ENDOMETRIOSIS
    Victoria Holt; Fiscal Year: 2005
    ..dietary and anthropometric measurements; and values of 4 genetic polymorphisms (GSTM1, COMT, CYP1A1, CYP1A2) will be combined with additional interview information to be collected between 48-84 months after initial ..
  29. DRUG METABOLIZING ENZYMES-RISK FACTORS IN BLADDER CANCER
    Robert Branch; Fiscal Year: 2004
    ..to use measures of whole body activity for drug metabolizing enzymes using the Pittsburgh cocktail that comprises CYP1A2 (caffeine), CYP2C19 (S-mephenytoin), CYP2D6 (debrisoquine), CYP2E1 (chlorzoxazone) and CYP3A4 (dapsone), as well ..
  30. REGULATION OF POLYCYCLIC AROMATIC HYDROCARBON TOXICITY
    WILLIAM HOUSER; Fiscal Year: 1992
    ..on a detailed analysis of the mechanisms which regulate the expression of an important enzyme activity, aryl hydrocarbon hydroxylase (AHH)...
  31. Effects of Ginseng and Ginkgo on Drug Disposition in Man
    Aryeh Hurwitz; Fiscal Year: 2003
    ..a 4-week single-blind run-in subjects will be given a 4-drug probe cocktail: caffeine to study cytochrome P4501A2 (CYP1A2), dextromethorphan for CYP2D6, buspirone (and endogenous cortisol) for CYP3A and fexofenadine for P-glycoprotein...
  32. Alcohol and Acetaminophen Hepatotoxicity
    Jacqueline Sinclair; Fiscal Year: 2006
    ..However, our work suggests that CYP3A also has a role. We have recently found that alcohols also induce CYP1A2, another form of CYP that produces the reactive metabolite of APAP...
  33. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..These genes include CYP1A1, CYP1A2, CYP1B1, catechol 0-methyl transferase, sulfotransferase 1A1, and glutathione S-transferases (M1, P1, and T1)...
  34. St. John's Wort and CYP3A Metabolism in Men & Women
    Reginald Frye; Fiscal Year: 2003
    ..The second specific aim is to study the effects of St. John's Wort on other CYP pathways, specifically CYP1A2 using caffeine as a probe, CYP2C9 using flurbiprofen as a probe, and CYP2C19 using mephenytoin as a "cocktail" ..
  35. ABNORMAL FETAL DEVELOPMENT DUE TO TOXIC EXPOSURE
    MRINAL SANYAL; Fiscal Year: 1991
    ..g., benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene). Benzo[a]pyrene hydroxylase (Aryl hydrocarbon hydroxylase) and other mixed function oxidase (MFO) enzyme activities are to be measured in human placental tissues ..
  36. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  37. CHEMOPREVENTIVE AGENTS AND HUMAN CYTOCHROME P450 IN VIVO
    GRANT WILKINSON; Fiscal Year: 2002
    ..The CYP isoforms of interest and the associated in vivo probes will be CYP1A2 (caffeine), CYP2A6 (coumarin), CYP2C9 (tolbutamide), CYP2C19 (mephenytoin), CYP2D6 (debrisoquine), CYP2E1(..
  38. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Mary Wolff; Fiscal Year: 1993
    ..The relationship of breast cancer to genetic polymorphisms in carcinogen metabolizing genes (CYP1A1, CYP1A2, CYP2E1, GST) will be determined...
  39. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..of a number of genes involved in the biosynthesis and catabolism of estrogens (CYP11a, CYP17, EDH17beta2, CYP1A1, CYP1A2, CYP1B1, COMT), and those for the androgen receptor, estrogen receptor and IGF-I genes are related to the risk of ..
  40. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    ..In the HPFS and NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
  41. Genetic Differences in PCB-Induced Behavior
    Daniel Nebert; Fiscal Year: 2009
    ..Despite this overriding role for planar-PCB-mediated AHR activation in toxicity, the AHR up-regulates CYP1A2, which in liver sequesters and protects distant tissues against planar PCBs...
  42. CYTOCHROME P450 GENES AND THEIR REGULATION
    Robert Tukey; Fiscal Year: 1999
    ..that when activated in the presence of ligand translocates to nucleus and couples with the nuclear aryl hydrocarbon hydroxylase nuclear translocator (ARNT) protein...
  43. DIETARY PROTEIN--FAT INTERACTIONS IN DMBA MAMMARY CANCER
    WILLARD VISEK; Fiscal Year: 1980
    ..Metabolites in urine and feces will be identified and quantitated. Liver aryl hydrocarbon hydroxylase and related mixed function oxidase components will be assayed to determine how the dietary variables ..
  44. DIOXIN TOXIC EQUIVALENCY FACTORS--BATTELLE MEMORIAL INST
    Milton Hejtmancik; Fiscal Year: 2000
    ..Interim evaluations to be performed at 13, 30 and 52 weeks will include: Thyroid hormones; liver CYP1A1, CYP1A2 and CYP1B1, UDP-GT, porphyrins and retinol; lung CYP1A1 and CYP1B1; tissue concentration of test chemical(s) in ..
  45. CYP gene polymorphism and estrogen status in the elderly
    Reina Villareal; Fiscal Year: 2005
    ..The primary aims of this proposal are 1) to determine the prevalence of gene polymorphism of CYP1A1, CYP1B1, CYP1A2 and CYP3A4 among women and men of different ethnic groups 2) to determine the functional correlates of ..
  46. ORAL CARCINOGENESIS, VITAMIN A AND RETINOIDS
    Gerald Shklar; Fiscal Year: 1980
    ..The presence of retinoids in the oral mucosa, dysplastic oral epithelium and carcinoma will be studied by autoradiographic techniques and by chemical techniques. Aryl hydrocarbon hydroxylase activity of tissues will also be studied.
  47. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..these polymorphisms that result in a deficiency in the production, stability and function of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the ..
  48. PCBS & ESTROGENS ON PROINFLAMMATORY PHAGOCYTE FUNCTIONS
    Charles Rice; Fiscal Year: 2000
    ..3 classes of pollutants: nonylphenol, a xenoestrogen; PCB 126, a planar PCB that binds to the aryl hydrocarbon hydroxylase receptor (Ahr); and PCB 104, a non-planar PCB that does not bind to Ahr...
  49. CARCINOGEN SUPPRESSION OF KERATINOCYTE DIFFERENTIATION
    Robert Rice; Fiscal Year: 1990
    ..and related compounds will be undertaken to find whether this property is characteristic of inducers of aryl hydrocarbon hydroxylase. In addition, possible benzo(a)pyrene uncoupling of the differentiation program in normal human ..
  50. MOLECULAR MARKERS OF ORAL CANCER RISK
    Philip Lazarus; Fiscal Year: 2000
    ..In addition, studies will be done to elucidate new polymorphic markers of OCSCC risk, focusing on the CYP1A2 enzyme, which is a strong metabolizer of the potent tobacco specific nitrosamine, NNK...
  51. FUNCTIONAL AND GENETIC ANALYSES OF HUMAN CYP1B1
    Thomas Sutter; Fiscal Year: 2000
    ..BP and PhIP are widespread procarcinogens known to be metabolized by the other CYP1 enzymes, CYP1A1 and CYP1A2. Pyrene is a co-carcinogen that is often used as a marker of human PAH exposure...
  52. RECEPTOR BINDING FACTOR FOR THE AH-RECEPTOR
    Mary Ruh; Fiscal Year: 1999
    ..We will determine if and where AhRBFs are associated with known dioxin-inducible genes, such as CYP1A1 or CYP1A2 and also determine the consensus DNA sequence to which these AhRBFs bind.
  53. HIGH VOLUME SCREENING FOR P450 INDUCTION
    Mei Fei Yueh; Fiscal Year: 2002
    ..During phase I, vectors were developed that contained the regulatory elements of CYP1A2 and CYP3A4 which when transiently transfected were responsive to drugs causing transcriptional activation of a ..
  54. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  55. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..b>CYP1A2 is responsible for metabolizing nitrosamines and N-heterocyclics, but also PAHs (in particular, BaP) to a lesser ..
  56. ENVIRONMENTAL FACTORS IN THE INDUCTION OF CANCER
    LEILA DIAMOND; Fiscal Year: 1980
    ..in the induction of biological effects; (b) test the hypothesis that various types of inducers of aryl hydrocarbon hydroxylase (AHH) share specific but common binding sites and a common pathway leading to the induction of the ..
  57. GENETICS OF AHH IN RELATION TO CANCER ETIOLOGY
    Beverly Paigen; Fiscal Year: 1980
    ..We have confirmed the report of others that aryl hydrocarbon hydroxylase (AHH) does vary in the population and that much of the variation is genetically determined...
  58. THE EFFECT OF CHEMICAL CARCINOGENS ON CELLS IN VITRO
    LEILA DIAMOND; Fiscal Year: 1980
    ..The levels of aryl hydrocarbon hydroxylase activity, the extent of hydrocarbon metabolism, the metabolite profiles, and the amounts and types of ..
  59. Gene Interactions, Estrogen, and Risk of Breast Cancer
    Kathleen Egan; Fiscal Year: 2006
    ..TNF, IL6, PPAR G, STS), in steroid signaling (ESR1, ESR2, PGR, SHBG, AIB1), and in estrogen metabolism (CYP1A1, CYP1A2, CYPIB1, CYP3A4) and inactivation (SULTs, UGTs, COMT, NQOs, GSTs)...
  60. CARCINOGEN-METABOLIZING ENZYMES--ACTION IN VARIANT CELLS
    James Whitlock; Fiscal Year: 1990
    ..molecular level how the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces aryl hydrocarbon hydroxylase (AHH) activity in mammalian cells...
  61. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..from the Investigator's Abstract) The long-term goal of this project is the elucidation of cytochrome P450 CYP1A2's role in toxicity and cancer caused by environmentally hazardous chemicals...
  62. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  63. MECHANISM OF PORPHYRIA CAUSED BY TCDD
    Peter Sinclair; Fiscal Year: 2002
    ..Induced CYP1A2 has been previously shown to be involved in the PHA-induced uroporphyria, this role being to catalyze the ..