Cyp1A1

Summary

Gene Symbol: Cyp1A1
Description: cytochrome P450 family 1 subfamily A member 1
Alias: AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, cytochrome P450 1A1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Species: human

Top Publications

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
  3. doi Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 30:585-95. 2011
  4. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
  5. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
  6. doi Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes
    Shiekh Tanveer Ahmad
    Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi, India
    Urol Oncol 31:1350-7. 2013
  7. doi Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers
    Li Liu
    State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
    Eur J Cancer 49:2143-51. 2013
  8. ncbi GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study
    Samantha Manfredi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 621:106-12. 2007
  9. doi Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1
    Erin E Bessette
    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Albany, NY 12201 0509, USA
    J Biochem Mol Toxicol 23:222-32. 2009
  10. doi Association of CYP1A1*2A polymorphism with male infertility in Indian population
    Gudimella Tirumala Vani
    Institute of Genetics and Hospital for Genetics Diseases, Osmania University, Begumpet, Hyderabad 500016, Andhra Pradesh, India
    Clin Chim Acta 410:43-7. 2009

Research Grants

  1. CYP1A1 GENOTYPE & INDUCIBIL PHENOTYPE-HUM LUNG CA RISK
    Jennifer Hu; Fiscal Year: 1992
  2. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
  3. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
  4. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
  6. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2013
  7. Alvaro Puga; Fiscal Year: 2015
  8. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
  9. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
  10. Bhagavatula Moorthy; Fiscal Year: 2015

Detail Information

Publications311 found, 100 shown here

  1. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..and 593 controls (433 matched case-control pairs) were genotyped for common polymorphisms in the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19 and CYP2D6), glutathione S-transferase (GSTM1, GSTP1 and GSTT1), ..
  2. doi Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, National University of Athens, Athens, Greece
    Breast Cancer Res Treat 122:459-69. 2010
    Cytochrome P450s are enzymes which catalyze Phase-I metabolism reactions; cytochrome P450 1A1 (CYP1A1) is a member of the CYP1 family and participates in the metabolism of a vast number of xenobiotics, as well as endogenous substrates...
  3. doi Soy isoflavones, CYP1A1, CYP1B1, and COMT polymorphisms, and breast cancer: a case-control study in southwestern China
    Qiong Wang
    Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, PR China
    DNA Cell Biol 30:585-95. 2011
    b>CYP1A1, CYP1B1, and COMT are key enzymes involved in estrogen metabolism. Soy isoflavones, phytoestrogens found in soy foods, may modify the activity of these enzymes...
  4. ncbi Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers
    K Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
    Cancer Res 61:3770-4. 2001
    ..to ATL and several polymorphisms: the three "decreased-detoxifying" polymorphisms in GSTM1, GSTT1, and CYP1A1, the "proapoptotic" polymorphism in BCL2, and the five "high-production" polymorphisms in tumor necrosis factor ..
  5. pmc Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Genet 7:e1002033. 2011
    ..4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2...
  6. doi Risk of renal cell carcinoma and polymorphism in phase I xenobiotic metabolizing CYP1A1 and CYP2D6 enzymes
    Shiekh Tanveer Ahmad
    Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard Hamdard University, New Delhi, India
    Urol Oncol 31:1350-7. 2013
    ..The possible association between RCC and a polymorphism of the CYP1A1 and CYP2D6 genes specific to the Indian population was examined using peripheral blood DNA from 196 RCC cases and ..
  7. doi Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers
    Li Liu
    State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
    Eur J Cancer 49:2143-51. 2013
    b>CYP1A1 plays an essential role in pathogenesis of head and neck cancers. Functional CYP1A1 Ile462Val and MspI single nucleotide polymorphisms (SNP) are considered to have significant effects on risk of head and neck cancers...
  8. ncbi GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study
    Samantha Manfredi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 621:106-12. 2007
    ..The purpose of this study was to test the hypothesis that the inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1 MspI) and glutathione S-transferases (GSTM1(null) and GSTT1(null)) may be causally associated with ..
  9. doi Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1
    Erin E Bessette
    Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Albany, NY 12201 0509, USA
    J Biochem Mol Toxicol 23:222-32. 2009
    ..cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites...
  10. doi Association of CYP1A1*2A polymorphism with male infertility in Indian population
    Gudimella Tirumala Vani
    Institute of Genetics and Hospital for Genetics Diseases, Osmania University, Begumpet, Hyderabad 500016, Andhra Pradesh, India
    Clin Chim Acta 410:43-7. 2009
    The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs)...
  11. pmc CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis
    Jian Qiang Jin
    Department of Pathology, Affiliated No 4 Hospital of Soochow University, Wuxi 214062, Jiangsu Province, China
    World J Gastroenterol 17:260-6. 2011
    To study the relation between CYP1A1 Ile462Val polymorphism and colorectal cancer risk by meta-analysis.
  12. doi Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies
    Lei Yu
    Department of Infectious Disease, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China
    Mol Biol Rep 39:6641-6. 2012
    The Cytochrome P-450 1A1 (CYP1A1) gene has been implicated in the etiology of hepatocellular carcinoma (HCC). However, the results have been inconsistent...
  13. ncbi Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis
    Theodoros N Sergentanis
    School of Medicine, University of Athens, Athens, Greece
    Mol Biol Rep 39:9921-30. 2012
    ..aims to examine whether the genotype status of MspI, Ile462Val, and Thr461Asn polymorphisms in Cytochrome P450 1A1 (CYP1A1) is associated with ovarian cancer risk...
  14. doi CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis
    ShuYan Yang
    Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Harbin Medical University, Harbin 150001, China
    Tumour Biol 33:2265-72. 2012
    Many publications have evaluated the correlation between Cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and cervical cancer risk, but the results remain inconclusive...
  15. pmc Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans
    Mandana Ghisari
    Centre for Arctic Health and Unit of Cellular and Molecular Toxicology, Department of Public Health, Aarhus University, Denmark
    Int J Circumpolar Health 72:21113. 2013
    ....
  16. ncbi Relationship between genetic polymorphisms of drug-metabolizing enzymes (CYP1A1, CYP2E1, GSTM1, and NAT2), drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Gastroenterol 39:220-30. 2004
    ..Therefore, we studied the relationship between the genetic polymorphisms of drug-metabolizing enzymes, drinking habits, histological subtypes, and p53 gene point mutations in Japanese patients with gastric cancer...
  17. doi Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia
    Yao Dong Zhang
    Department of Endocrinology, Zhengzhou Children s Hospital, Zhengzhou 450053, Henan, China
    Biomed Environ Sci 24:683-7. 2011
    To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).
  18. doi Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses
    Wen lei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Arch Med Res 40:169-79. 2009
    Previous studies have implicated cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) polymorphisms as risk factors for various cancers...
  19. ncbi Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility
    Mihi Yang
    Department of Toxicology, College of Pharmacy, Sookmyung Women s University, 53 12 Chungpa Dong, Yongsan gu, Seoul 140 742, Republic of Korea
    Lung Cancer 57:135-42. 2007
    ..As results, genetic polymorphisms in the GSTP1, MPO, and CYP1A1 among the genetic factors showed associations with lung cancer risk...
  20. pmc Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women
    Michele L Cote
    Population Studies and Prevention Program, Karmanos Cancer Institute, 110 East Warren Avenue, Detroit, MI 48201, USA
    Carcinogenesis 30:626-35. 2009
    ..Eleven SNPs in 10 different genes were examined in relation to risk: CYP1A1 Msp1, CYP1A1 Ile462Val, CYP1B1 Leu432Val, CYP17, CYP19A1, XRCC1 Gln399Arg, COMT Val158Met, NQO1 Pro187Ser, GSTM1, ..
  21. doi Association between CYP1A1 polymorphism and colorectal cancer risk: a meta-analysis
    Yuan Zheng
    Department of Center for Disease Control and Prevention of Shaanxi Province, 3Jiandong Road, 710054, Shaanxi, Xi an, People s Republic of China
    Mol Biol Rep 39:3533-40. 2012
    ..Published data on the association between CYP1A1 (MspI and Ile ( 462 ) ..
  22. ncbi Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure
    P Piirilä
    Departments of Occupational Medicine, Finnish Institute of Occupational Health, Helsinki, Finland
    Pharmacogenetics 11:437-45. 2001
    ..0, 95% CI 2.19-55.3). The results suggest, for the first time, that the polymorphic GSTs, especially the mu class GSTs, play an important role in inception of ill effects related to occupational exposure to diisocyanates...
  23. ncbi CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people
    L Quinones
    Faculty of Medicine, Laboratory of Environmental Toxicology and School of Public Health, University of Chile, Santiago, Chile
    Cancer Lett 174:35-44. 2001
    b>CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients...
  24. ncbi Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users
    Nilabja Sikdar
    Anthropology and Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
    Cancer Lett 195:33-42. 2003
    ..In this study, we investigated polymorphisms at two sites in the CYP1A1 and three sites in the CYP2E1 genes in 99 leukoplakia patients and 227 controls from one Indian population...
  25. ncbi Relationship between CYP1A1 genetic polymorphisms and renal cancer in China
    Junxiang Chen
    Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China
    Asian Pac J Cancer Prev 12:2163-6. 2011
    To study the potential role of cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms in the risk of renal cell cancer in Chinese.
  26. doi Quantitative assessment of the associations between CYP1A1 polymorphisms and gastric cancer risk
    Renyong Guo
    Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Tumour Biol 33:1125-32. 2012
    A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published. However, the results have been inconsistent...
  27. doi CYP1A1 gene polymorphisms and smoking status as modifier factors for lung cancer risk
    Atef G Hussein
    Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
    Gene 541:26-30. 2014
    ..The aim of this work was to identify the correlation between CYP1A1 m1 and m2 polymorphisms and lung cancer risk and figure its interactions with smoking as genetic modifiers in the ..
  28. ncbi Effect of CYP1A1 MspI polymorphism on cigarette smoking related coronary artery disease and diabetes
    Xing Li Wang
    Cardiovascular Genetics Laboratory, Eastern Heart Clinic, Center of Thrombosis and Vascular Research, University of New South Wales, Sydney, Australia
    Atherosclerosis 162:391-7. 2002
    b>CYP1A1, is one of the key detoxifying enzymes catabolizing cigarette smoking derived toxins and may be relevant to smoking-induced atherogenesis...
  29. ncbi [Analysis of the polymorphic alleles of genes encoding phase 1 and phase 2 detoxication enzymes in patients with endometriosis]
    T E Ivashchenko
    Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, 199034 Russia
    Genetika 39:525-9. 2003
    Polymorphysms of the three genes encoding phase 1 (CYP1A1, mEPH1, and CYP2E2) and the three genes encoding phase 2 (NAT2, GSTM1, and GSTT1) xenobiotic detoxication enzymes were typed by use of PCR in 74 patients with extragenital ..
  30. ncbi The risk of developing cervical cancer in Mexican women is associated to CYP1A1 MspI polymorphism
    Teresa Juarez-Cedillo
    Epidemiological Research and Health Services Unit, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Eur J Cancer 43:1590-5. 2007
    The aim of the study was to evaluate the association of two CYP1A1 polymorphisms (Msp1 and exon 7) with cervical cancer in Mexican women considering their smoking habit...
  31. ncbi Association of CYP1A1 polymorphisms with breast cancer in North Indian women
    Neetu Singh
    Genotoxicity Laboratory, Toxicology Division, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Oncol Res 16:587-97. 2007
    ..In the present case control study four CYP1A1 gene polymorphisms, m1 (T6235C), m2 (A4889G), m3 (T5639C), and m4 (C4887A) were studied for their association with ..
  32. doi Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility
    Sena Erdogan Aydos
    Department of Medical Biology, Faculty of Medicine, Ankara University, Ankara, Turkey
    Fertil Steril 92:541-7. 2009
    To examine whether a relationship exists between genetic polymorphisms of glutathione S-transferase (GST) M1 and T1, CYP1A1(*)2C, and male factor infertility.
  33. doi Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking
    Munish Kumar
    Petroleum Toxicology Division, Indian Institute of Toxicology Research, M G Marg, P O Box No 80, Lucknow, 226001, India
    Mol Cell Biochem 322:73-9. 2009
    ..The polymorphic genes explored were CYP1A1, GSTM1, GSTP1 and GSTT1 using techniques of Polymerase chain reaction (PCR), Restriction Fragment Length ..
  34. doi Polymorphisms of cytochrome P450 1A1, cigarette smoking and risk of coronary artery disease
    Chih Ching Yeh
    Department of Health Risk Management, China Medical University College of Public Health, Taichung 404, Taiwan
    Mutat Res 667:77-81. 2009
    ..b>Cytochrome P450 1A1 (CYP1A1) is a key enzyme that metabolizes the cigarette toxin relevant to smoking-induced atherogenesis...
  35. doi Evidence for increased cytochrome P450 1A1 expression in blood lymphocytes of lung cancer patients
    Parag P Shah
    Developmental Toxicology Division, Indian Institute of Toxicology Research IITR, CSIR, MG Marg, Lucknow, UP, India
    Mutat Res 670:74-8. 2009
    To develop blood lymphocyte cytochrome P450 1A1 (CYP1A1) expression as a surrogate for monitoring tissue expression for polycyclic aromatic hydrocarbon (PAH) induced toxicity, the present study attempted to characterize CYP1A1 mRNA ..
  36. doi Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population
    Jufeng Zhang
    Biomedical Research Institute, Shenzhen PKU HKUST Medical Center, Shenzhen, 518036, China
    Clin Chim Acta 411:878-81. 2010
    GSTT1, GSTM1, CYP1A1 are enzymes responsible for the detoxification of the toxicant which may be involved in the development of systemic lupus erythematosus (SLE)...
  37. doi CYP1A1 polymorphism in adolescents with polycystic ovary syndrome
    Sinem Akgul
    Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Int J Gynaecol Obstet 112:8-10. 2011
    To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.
  38. ncbi The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population
    Tulin Ozturk
    Department of Pathology, Faculty of Cerrahpasa Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
    In Vivo 25:663-8. 2011
    The aim of this study was to investigate a possible association of the CYP1A1 Ile462Val and GSTM1 null polymorphisms with the risk of developing bladder cancer in a Turkish population.
  39. doi Analysis of GSTM1, GSTT1, and CYP1A1 in idiopathic male infertility
    Zivar Salehi
    Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
    Reprod Sci 19:81-5. 2012
    ..a genetic association of the biotransformation enzymes and idiopathic male fertility, we studied GSTT1, GSTM1, and CYP1A1*2A polymorphisms in 150 infertile men and 200 healthy men as controls from Northern Iran...
  40. doi Does cytochrome P450 1A1 MspI polymorphism increase acute lymphoblastic leukemia risk? Evidence from 2013 cases and 2903 controls
    Wenlei Zhuo
    Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Gene 510:14-21. 2012
    Previous studies indicated that cytochrome P450 1A1 (CYP1A1) MspI polymorphism might be a possible risk factor for several malignancies...
  41. doi Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and prostate cancer risk
    Guangye Han
    Urology Department, The First Affiliated Hospital of Xinxiang Medical University, Healthy Road No 88, Weihui, Henan, 453100, China
    Tumour Biol 34:1511-6. 2013
    The association between the cytochrome P450 1A1 (CYP1A1) Ile462Val polymorphism and prostate cancer risk remains inconclusive owing to the conflicting findings from previous studies...
  42. doi Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease
    Sergey L Yarosh
    1Family Planning and Reproductive Health Clinic, Regional Perinatal Center, Kursk, Russian Federation
    Reprod Sci 20:1302-7. 2013
    The study was designed to investigate the associations of polymorphisms Ile462Val and 3801T>C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) and to assess the impact of smoking status on the ..
  43. ncbi Influence of antioxidants and the CYP1A1 isoleucine to valine polymorphism on the smoking--lung cancer association
    D Ratnasinghe
    Division of Clinical Sciences, National Cancer Institute, NIH, Bethseda, MD, USA
    Anticancer Res 21:1295-9. 2001
    To evaluate the association between CYP1A1 genotype and lung cancer risk and to assess the effect of CYP1A1 genotype and antioxidant supplementation on the smoking--lung cancer relationship we conducted a case-control study nested within ..
  44. pmc Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an
    An hui Wang
    Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University Xi an 710032, Shaanxi Province, China
    World J Gastroenterol 8:49-53. 2002
    To analyze the association of tobacco smoking polymorphism of CYP1A1 (7th exon) and GSTM1 genotype and esophageal cancer(EC) in Xi'an.
  45. ncbi Cytochrome P450 1A1 polymorphism and childhood leukemia: an analysis of matched pairs case-control genotype data
    Steve Selvin
    School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Cancer Epidemiol Biomarkers Prev 13:1371-4. 2004
    The association between the genotypic frequencies of the cytochrome P450 1A1 polymorphism and the risk of childhood leukemia is explored with the data from a matched case-control study...
  46. ncbi The GST deletions and NQO1*2 polymorphism confers interindividual variability of response to treatment in patients with acute myeloid leukemia
    Eva Barragan
    Molecular Biology Laboratory, Dpt Medical Pathology, Spain
    Leuk Res 31:947-53. 2007
    ..patients diagnosed with de novo acute myeloid leukemia (AML) to clarify the influence of the genetic polymorphisms CYP1A1*2A, CYP3A4*1B, CYP2E1*5B, del{GSTT1}, del{GSTM1}, and NQO1*2 on disease outcome...
  47. doi Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility
    Han Chun Chen
    Department of Biochemistry, School of Biological Science and Technology, Central South University, Changsha, Hunan, China
    Eur J Cancer Prev 17:251-8. 2008
    The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), and phase II enzymes, glutathione S-transferase (GSTM1 and GSTT1), were analyzed in 204 healthy persons and 348 leukemia patients, who ..
  48. ncbi CYP1A1 m1 and m2 polymorphisms: genetic susceptibility to lung cancer
    Paula Mota
    Instituto de Genetica, Faculdade de Medicina, 3000 Coimbra
    Rev Port Pneumol 16:89-98. 2010
    ..The CYP1A1 gene codifies the phase I enzyme aryl hydrocarbon hydroxilase (AHH) belonging to the cytochrome P450 system that ..
  49. pmc CYP1A1 gene polymorphisms as a risk factor for pterygium
    Chi Hsien Young
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Mol Vis 16:1054-8. 2010
    Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs)...
  50. ncbi Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients
    M P Gallegos-Arreola
    Division de Medicina Molecular, Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco, Mexico
    Blood Cells Mol Dis 33:326-9. 2004
    We studied the role of cytochrome P4501A1 (CYP1A1 Val/Val) genotypes in the etiology of acute lymphoblastic leukemia (ALL) in adult Mexican patients...
  51. ncbi Identification of cytochrome P450 1A1 in human brain
    C H Yun
    Department of Biochemistry, Pai Chai University, Taejon, Korea
    Biochem Biophys Res Commun 243:808-10. 1998
    ..We demonstrated for the first time that human brain contains a P450 1A1-dependent metabolism system which seems to be important for understanding the metabolism of endogenous and exogenous compounds...
  52. ncbi Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women
    Sonia M Boyapati
    Department of Medicine, Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer 103:2228-35. 2005
    b>Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma.
  53. ncbi Urinary 1-hydroxypyrene level relative to vehicle exhaust exposure mediated by metabolic enzyme polymorphisms
    Chun Yu Chuang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan
    J Occup Health 49:140-51. 2007
    ..12 +/- 0.05 vs. 0.07 +/- 0.03 micromol/mol creatinine). The subjects with the m1/m2 or m2/m2 genotype of CYP1A1 MspI or GSTM1 deficiency had significantly higher urinary 1-OHP levels than those with other CYP1A1 MspI and GSTM1 ..
  54. ncbi The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers
    Bo Chen
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, 200032, PR China
    Sci Total Environ 381:38-46. 2007
    ..No influence was found in the association between urinary 1-OHP and other genetic polymorphisms such as CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, EPHX2 in this population.
  55. ncbi Serum increases CYP1A1 induction by 3-methylcholanthrene
    Quoc Binh N'Guyen
    UMR CNRS 6032, Faculte de Pharmacie, Universite Mediterranee, 27 Boulevard Jean Moulin, FR 13385, Marseille Cedex, France
    Biochem Biophys Res Commun 297:249-54. 2002
    b>CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway...
  56. ncbi Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China
    L Yin
    School of Public Health, Southeast University, Nanjing, PR China
    Lung Cancer 33:133-41. 2001
    ..Genetic polymorphisms of NAD(P)H quinone oxidoreductase (NQO1), cytochrome P4501A1 (CYP1A1) and microsomal epoxide hydrolase (HYL1) have been associated with increased lung cancer risk in Asian populations...
  57. ncbi Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer
    Matthias Hahn
    Institute of Pathology, Department of Medicine of the Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer, 68135 Mannheim, Germany
    Oral Oncol 38:486-90. 2002
    ..DNA of 94 Caucasian patients in Germany and 92 healthy German controls to determine genotypes of polymorphisms in CYP1A1, GSTM1 and NAT2. For CYP1A1, the homozygous mutant genotype Val/Val did not occur...
  58. ncbi Interaction of cytochrome P4501A1 genotypes with other risk factors and susceptibility to lung cancer
    Parag P Shah
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Mutat Res 639:1-10. 2008
    ..population, the present case-control study attempted to investigate the association of polymorphisms in cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1) with risk to squamous cell carcinoma of lung malignancy...
  59. ncbi CYP1A1 gene polymorphism as a risk factor for cervical intraepithelial neoplasia and invasive cervical cancer
    Cagatay Taskiran
    Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, 06100, Sihhiye, Ankara, Turkey
    Gynecol Oncol 101:503-6. 2006
    The purpose of this study was to evaluate the role of CYP1A1*3 gene polymorphism in the development of cervical cancer by comparing patients having cervical intraepithelial neoplasia (CIN) or invasive cervical cancer with control subjects.
  60. ncbi CYP1A1, cigarette smoking, and colon and rectal cancer
    Martha L Slattery
    Health Research Center, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Am J Epidemiol 160:842-52. 2004
    ..The authors evaluated the association of two polymorphisms in the CYP1A1 gene--the noncoding Msp I polymorphism in the 3'-untranslated region and the Ile462Val polymorphism in exon 7--..
  61. ncbi Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children
    Thomas Joseph
    Department of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram, India
    Pediatr Blood Cancer 43:560-7. 2004
    ..These variations could play a role in the risk of developing paediatric acute lymphoblastic leukaemia (ALL) by their varying action on environmental carcinogens...
  62. ncbi Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer risk
    Kathryn L Terry
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:187-90. 2003
    Aromatic hydrocarbon hydroxylase (CYP1A1) is involved in the metabolism of many substrates and the subject of cancer studies. This study examined the association between two polymorphic variants of CYP1A1 and ovarian cancer risk...
  63. ncbi Ovarian cancer risk and polymorphisms involved in estrogen catabolism
    Sarah K Holt
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, P O Box 19024 M4 C308, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:481-9. 2007
    ..Subjects were interviewed and genotyped for CYP1A1 m1, m2, m3, and m4; CYP1B1 Arg(48)Gly, Ala(119)Ser, Val(432)Leu, and Asn(453)Ser; COMT Val(158)Met; UGT1A1 A(TA)..
  64. pmc Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, and Caucasian mothers and newborns
    Shuang Wang
    Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 17:405-13. 2008
    ..play an important role in the metabolic activation or detoxification of PAHs, including the cytochrome P450 genes CYP1A1 and CYP1B1 and the glutathione S-transferase (GST) genes GSTM1, and GSTT2...
  65. ncbi Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1
    J H van Delft
    Toxicology Division, TNO Nutrition and Food Research Institute, P O Box 360, 3700 AJ, Zeist, The Netherlands
    Ann Occup Hyg 45:395-408. 2001
    ..Human exposure is often demonstrated by increased internal levels of PAH metabolites and of markers for early biological effects, like DNA adducts and cytogenetic aberrations...
  66. ncbi Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects
    V R Arruda
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Eur J Haematol 66:383-8. 2001
    ..Both the GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null variant allele in which the entire gene is absent. In this study, we tested whether null genotypes for the GSTM1 and GSTT1 genes altered the risks for MDS, AML and AA...
  67. ncbi The effect of relevant genotypes on PAH exposure-related biomarkers
    Terhi Kuljukka-Rabb
    Institute of Occupational Health, FIN 00250 Helsinki, Finland
    J Expo Anal Environ Epidemiol 12:81-91. 2002
    ..Urinary mutagenicity was measured using the Ames test. CYP1A1, microsomal epoxide hydrolase (mEH), and glutathione S-transferase (GST) genotypes were analyzed by polymerase ..
  68. ncbi Susceptibility factors and DNA adducts in peripheral blood mononuclear cells of aluminium smelter workers exposed to polycyclic aromatic hydrocarbons
    Rainer Tuominen
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE 171 77 Stockholm, Sweden
    Arch Toxicol 76:178-86. 2002
    ..Genetic polymorphisms for cytochrome P-4501A1 ( CYP1A1), microsomal epoxide hydrolase, N-acetyltransferase 2, glutathione transferases M1, P1 and T1 ( GSTM1, GSTP1 and ..
  69. ncbi Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk
    Ian Kerridge
    Hunter Haematology Research Group, Newcastle Mater Hospital, Newcastle, Australia
    Br J Haematol 118:477-81. 2002
    ..Polymorphisms of six xenobiotic genes (CYP1A1, GSTT1, GSTM1, PON1, NAT1, NAT2) were characterized in 169 individuals with NHL and 205 normal controls using ..
  70. ncbi A population-based study of the Arg399Gln polymorphism in X-ray repair cross- complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma
    Eric J Duell
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:4630-6. 2002
    ..We also assessed potential gene-gene interactions between polymorphisms in XRCC1 and CYP1A1, GSTT1, and GSTM1...
  71. ncbi CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controls
    Paolo Vineis
    Universita degli Studi di Torino, Torino, Italy
    Int J Cancer 104:650-7. 2003
    b>CYP1A1 is involved in the metabolism of benzopyrene, a suspected lung carcinogen; it is therefore conceivable that genetically determined variations in its activity modify individual susceptibility to lung cancer...
  72. ncbi Polymorphisms in steroid hormone pathway genes and mammographic density
    Christopher A Haiman
    Department of Epidemiology, Harvard School of Public Health Boston, MA, USA
    Breast Cancer Res Treat 77:27-36. 2003
    ..investigate variation in mammographic breast density, by 10 polymorphisms in eight candidate genes (CYP17, CYP19, CYP1A1, CYP1B1, COMT, UGT1A1, AR, and AIB1). Breast density was assessed using a computer-assisted technique...
  73. ncbi Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites
    E Seree
    FRE Centre National de la Recherche Scientifique, Faculte de Pharmacie, Marseille, France
    Gastroenterology 127:1436-45. 2004
    b>Cytochrome P450 1A1 catalyzes the degradation of endobiotics (estradiol, fatty acids, and so on) and the bioactivation of numerous environmental procarcinogens, such as arylamines and polycyclic aromatic hydrocarbons, that are found in ..
  74. ncbi EPHX1 polymorphisms and the risk of lung cancer: a HuGE review
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epidemiology 17:89-99. 2006
    ..The aim of this study is to review and summarize the available molecular epidemiologic studies of lung cancer and EPHX1...
  75. ncbi Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China
    Yueping Shen
    School of Radiation Medicine and Public Health, Soochow University, Suzhou, PR China
    Cancer Epidemiol Biomarkers Prev 15:342-7. 2006
    ..We examined whether CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI genetic polymorphisms could increase the risk of breast cancer among Chinese ..
  76. ncbi A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
    Rika Ueda
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki aoba 6 3, Aoba ku, Sendai 980 8578, Japan
    Mol Pharmacol 69:1924-30. 2006
    The human CYP1A1 and CYP1A2 genes on chromosome 15 are orientated head-to-head and are separated by a 23-kilobase (kb) intergenic spacer region...
  77. ncbi GSTM1 and CYP1A1 polymorphisms, tobacco, air pollution, and lung cancer: a study in rural Thailand
    Paola Pisani
    Descriptive Epidemiology Group, IARC, Lyons, France
    Cancer Epidemiol Biomarkers Prev 15:667-74. 2006
    ..The presence of several large open-cast coal mines from 1955 close to electricity-generating plants was a particular focus of concern...
  78. ncbi Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    Cytochrome P-450 CYP1A1 is involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs) that are derived from meat intake and tobacco smoking...
  79. ncbi The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil
    Christian C Abnet
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 320, MSC 7232, Rockville, MD 20852, USA
    Carcinogenesis 28:112-7. 2007
    ..010. Variants in aryl hydrocarbon receptor (Ahr) (rs4986826), CYP1A1 (rs1799814) and CYP1A2 (rs2069514) were also, although less strongly, associated with changes in urine 1-OHPG ..
  80. ncbi Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1
    Celia P Martinez-Jimenez
    Unidad de Hepatologia Experimental, Centro de Investigacion, Hospital La Fe, Avenida de Campanar, 21, 46009 Valencia, Spain
    Mol Pharmacol 70:1681-92. 2006
    ..transfection of PGC1alpha in human hepatoma cells caused a significant dose-dependent increase in CYP2C9, CYP1A1, and CYP1A2 and in the positive control CYP7A1...
  81. ncbi CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis
    Xiuquan Shi
    Department of Epidemiology and Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    Lung Cancer 59:155-63. 2008
    Genetic polymorphisms of cytochrome p450 (CYP1A1) and glutathione S-transferase M1 (GSTM1) genes are thought to have significant effects on the metabolism of environmental carcinogens and thus on cancer risk, but the reported results are ..
  82. ncbi CYP1A1 *2B and *4 polymorphisms are associated with lung cancer susceptibility in Mexican patients
    M P Gallegos-Arreola
    Molecular Genetics Laboratory, Division of Molecular Medicine, Centro de Investigacion Biomedica de Occidente, Guadalajara, Jalisco Mexico
    Int J Biol Markers 23:24-30. 2008
    CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk...
  83. ncbi A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility
    I Cascorbi
    Institute of Clinical Pharmacology, University Clinic Charite, Humboldt University of Berlin, Germany
    Cancer Res 56:4965-9. 1996
    This study reports a C-->A transversion at position 4887 in exon 7 of cytochrome P4501A1 (CYP1A1), resulting in a threonine-asparagine exchange in codon 461...
  84. ncbi CYP 1A1 polymorphism and risk of lung cancer in relation to tobacco smoking: a case-control study in China
    N Song
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Carcinogenesis 22:11-6. 2001
    The impact of genetic polymorphisms in CYP1A1 on susceptibility to lung cancer has received particular interest in recent years since this enzyme plays a central role in activation of major classes of tobacco carcinogens...
  85. ncbi Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation
    J Corchero
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pharmacogenetics 11:1-6. 2001
    ..A human genomic clone from a BAC library, containing both CYP1A1 and CYP1A2 genes, was isolated and sequenced...
  86. ncbi Polymorphisms of the CYP1A1 and GSTM1 genes in relation to individual susceptibility to lung carcinoma in Chinese population
    S Chen
    Laboratory of Genetics, Jiangsu Institute for Cancer Research, 210009, Nanjing, PR China
    Mutat Res 458:41-7. 2001
    b>Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) metabolize tobacco-related carcinogens...
  87. ncbi Metabolic gene polymorphism frequencies in control populations
    S Garte
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Epidemiol Biomarkers Prev 10:1239-48. 2001
    ..noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined...
  88. ncbi Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia
    Maja Krajinovic
    Service d hématologie oncologie, Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, H3T 1C5 Canada
    Clin Cancer Res 8:802-10. 2002
    ..Similarly, differential capacity of ALL patients to process carcinogens and chemotherapeutic drugs could both modify an individual's risk of recurrent malignancy and response to therapy...
  89. ncbi Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
    E Taioli
    Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, Italy
    Int J Epidemiol 32:60-3. 2003
    ..The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk...
  90. ncbi CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis
    Rayjean J Hung
    Unit of Environmental Cancer Epidemiology, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372 Lyon Cedex 08, France
    Carcinogenesis 24:875-82. 2003
    Polymorphisms for genes encoding the metabolic enzymes cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung cancer...
  91. ncbi Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia
    Gunay Balta
    Hacettepe University, Faculty of Medicine, Department of Pediatrics, Institute of Child Health and Section of Pediatric Hematology, Ankara, Turkey
    Am J Hematol 73:154-60. 2003
    ..reductase (MTHFR C677T), glutathione S-transferases (GSTM1 and GSTT1 null, GSTP1 Ile105Val), and cytochromes p450 (CYP1A1*2A) genotypes in the etiology of childhood leukemia was simultaneously investigated...
  92. ncbi Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
    Loic Le Marchand
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, USA
    Cancer Causes Control 14:339-46. 2003
    b>Cytochrome P450 1A1 plays a major role in the bioactivation of a number of tobacco procarcinogens...
  93. ncbi Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population
    Anna Karin Alexandrie
    Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Cancer Epidemiol Biomarkers Prev 13:908-14. 2004
    ..We identified previously the possible modifying influence of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population...
  94. ncbi Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia
    Francesco D'Alo
    Istituto di Ematologia, Universita Cattolica S Cuore, Rome, Italy
    Haematologica 89:664-70. 2004
    ..We studied the polymorphisms of cytochrome P450 CYP1A1 and glutathione S-transferase (GST), enzymes involved in the metabolism of carcinogens and anti-cancer drugs, as ..
  95. ncbi Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population
    Joseph F Solus
    BioVentures, Inc, Murfreesboro, TN, USA
    Pharmacogenomics 5:895-931. 2004
    ..I drug metabolism genes, the exons and flanking intronic regions of the cytochrome P450 (CYP) isoenzyme genes CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4 and CYP3A5 were amplified from genomic ..
  96. ncbi The CYP1A1 genotype may alter the association of meat consumption patterns and preparation with the risk of colorectal cancer in men and women
    Maureen A Murtaugh
    Health Research Center, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT 84101, USA
    J Nutr 135:179-86. 2005
    ..with meat preparation methods producing heterocyclic amines or polycyclic aromatic hydrocarbons is modified by the CYP1A1 genotype alone or in combination with the GSTM1 genotype or the NAT2 imputed phenotype...
  97. ncbi CYP1A1 polymorphisms and risk of lung cancer in non-smoking Chinese women: influence of environmental tobacco smoke exposure and GSTM1/T1 genetic variation
    Daniel P K Ng
    Department of Community, Occupational and Family Medicine, National University of Singapore, 16 Medical Drive MD3, Singapore 117597
    Cancer Causes Control 16:399-405. 2005
    We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women.
  98. ncbi Polymorphisms of drug-metabolizing enzymes and risk of childhood acute lymphoblastic leukemia
    S Pakakasama
    Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    Am J Hematol 79:202-5. 2005
    ..7; 95% CI, 1.0, 2.7). In contrast, the GSTT1 null genotype did not show this effect. Our data thus demonstrate that the GSTM1 null genotype might increase the risk of childhood ALL in a Thai population...
  99. ncbi Risk of non-small cell lung cancer and the cytochrome P4501A1 Ile462Val polymorphism
    Jill Everland Larsen
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Cancer Causes Control 16:579-85. 2005
    The Ile462Val substitution in the cytochrome P450 1A1 gene (CYP1A1) results in increased enzymatic activity...
  100. ncbi Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps
    Ellen L Goode
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center Seattle, WA, USA
    Carcinogenesis 28:328-41. 2007
    ..We hypothesized that genetic variation in the encoding genes NAT1, NAT2, SULT1A1, SULT1A2, CYP1A1 or EPHX1 is associated with risk of colorectal polyps and interacts with cigarette use or meat intake to modify ..
  101. ncbi Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions
    M Manuguerra
    ISI Foundation, Torino Italy
    Carcinogenesis 28:414-22. 2007
    ..40, P<0.037). For leukemia, a 3-loci model including RAD52-2259C>T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P<0.001) and a maximum CVC of 4.40 (P=0.086)...

Research Grants68

  1. CYP1A1 GENOTYPE & INDUCIBIL PHENOTYPE-HUM LUNG CA RISK
    Jennifer Hu; Fiscal Year: 1992
    ..The working hypothesis is that the measurements of CYP1A1 enzyme inducibility in HMLs may at least in part reflect the biological responses in the target lung tissue...
  2. Genetic Susceptibility Factors in Porphyria Cutanea Tarda (PCT)
    Karl Anderson; Fiscal Year: 2009
    ..DNA samples will be prepared from patients and controls and genotyped for specific CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 polymorphisms, and the results analyzed as related to phenotype (e.g...
  3. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..In the absence of PPAR/ expression, increased expression of CYP1B1 and CYP1A1 and some phase II enzymes does not occur after application of PAHs...
  4. Early Disease Biomarkers of PCB-exposed Human Population
    Sisir K Dutta; Fiscal Year: 2010
    ..PCBs and metabolites of PCBs that have been isolated from human blood and tissues, and the gene cytochrome P450 (CYP1A1), which mediates production of OH-PCB by oxidative metabolism, has been found to be 65-fold increased by PCB-77 in ..
  5. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  6. Role of hepatic and pulmonary P4501A enzymes in neonatal hyperoxic tissue injury
    XANTHI IOANNA COUROUCLI; Fiscal Year: 2013
    ..the hypothesis that prenatal or postnatal exposure of wild type (WT) (C57BL/6J) mice to the cytochrome P4501A1 (CYP1A1) inducer beta-naphthoflavone (BNF) will result in attenuation or potentiation, respectively, of acute lung and ..
  7. Alvaro Puga; Fiscal Year: 2015
    ..These changes inhibit recruitment of RNA polymerase II to the Cyp1a1 promoter, block BaP-inducible gene expression and stimulate the formation of BPDE-DNA adducts...
  8. Genomic profiling of yeast resistance to AFB1, a P450-activated carcinogen
    MICHAEL THOMAS FASULLO; Fiscal Year: 2013
    ..We previously were successful in introducing human CYP1A2 and CYP1A1 into yeast and activating a variety of carcinogens, including aflatoxin B1 (AFB1), benzo[a]pyrene dihydrodiol (BaP-..
  9. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..The results will advance the breast cancer field by characterizing the biological mechanism by which the metabolism of dietary omega-3 fatty acids is regulated by insulin-like growth factors to promote the growth of breast cancer. ..
  10. Bhagavatula Moorthy; Fiscal Year: 2015
    ..The central hypothesis of this application is that CYP1A1 and CYP1A2 enzymes play reciprocal roles in PAH-mediated carcinogenesis, and that a CYP1A2-dependent MC metabolite(..
  11. The Effect of Dietary Fat on Benzo(a)pyrene Induced Colon Cancer in Apc Min Mice
    DEACQUNITA LAQUADE DIGGS; Fiscal Year: 2010
    ..The expression of cytochrome P450 family of enzymes (CYP1A1 and 1B1), and glutatione-S-transferase, the generation of reactive metabolites of BaP, their distribution, and ..
  12. ROBERT VINCENT O'BRIEN; Fiscal Year: 2014
    ..We will use these ACP-P450 systems to engineer site-selective C-H oxidation of polyketides, which will expand the diversity of biologically active macrolides accessible through biotic synthesis. ..
  13. Molecular Genetics of Primary Congenital Glaucoma
    Mansoor Sarfarazi; Fiscal Year: 2010
    ..During the past award period we: 1)-showed that 8 orthologous members of CYP1-3 are present during uterine development in both human and mouse;2)-created an E...
  14. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..Alkanes and their metabolites are metabolized rapidly by high risk cytochrome P450 phenotypes (e.g., CYP1A1, CYP1A2 and CYP2E1) whose activity is induced by polycyclic aromatic hydrocarbons in tobacco smoke...
  15. HUMAN CYTOCHROME P450 EXPRESSION--ENVIRONMENTAL EFFECTS
    RONALD HINES; Fiscal Year: 1999
    DESCRIPTION: Human cytochrome P450 CYP1A1 is not normally expressed in adult tissues...
  16. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..In vivo reproductive measures include 3.5 day post coitum (dpc): a) blastocyst numbers;b) blastocyst TUNEL, CYP1A1, and GLUT levels and localization;c) RT-PCR of in vivo blastocyst and stromal cell CYP1A1 mRNA, and d) stromal ..
  17. Thomas R Sutter; Fiscal Year: 2014
    ..these genes are regulated by the AHR and EGFR pathways by mechanisms similar to what has been described for CYP1A1, the prototypic AHR-regulated gene...
  18. Mark E Hahn; Fiscal Year: 2014
    ..An inhibitor of AHR transcriptional activation function, AHR repressor (AHRR), has been identified, but its role in regulating AHR signaling remains enigmatic, and possible functions beyond ..
  19. Sakina E Eltom; Fiscal Year: 2014
    ..PAH activation of AhR is implicated in carcinogenesis through induction of CYP1 family of genes with subsequent generation of reactive metabolites and activation of transcription factors...
  20. The role of the aryl hydrocarbon receptor in colon tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2012
    ..Use models of conditional activation of AHR to determine tissue autonomy of AHR signaling and susceptibility to CRC. Aim 3. Clarify the underlying mechanism of AHR-mediated tumor suppression using recombinant alleles of Arnt and Ahrr.
  21. ENDOGENOUS CYP1B1 SUBSTRATES AS AHR LIGANDS
    Craig Marcus; Fiscal Year: 2003
    ..II) The toxicological significance of prolonged Ahr-induced activation of CYP1A1, 1B1, and 1A2 expression many also be an important aspect PAH toxicity...
  22. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  23. PROTEIN KINASE C REGULATION OF P450 SYSTEM
    John Reiners; Fiscal Year: 2000
    ..Recent analyses of the expression of select members (Cyp1a1, Cyp1b1, Adhd4, and Nmo1) of the Ah battery in cells transfected with an oncogenic Ha-ras gene, or treated with 12-..
  24. STUDIES ON THE HALOGENATED AROMATIC HYDROCARBONS
    ALAN POLAND; Fiscal Year: 1990
    ..The induction of the microsomal monooxygenase, aryl hydrocarbon hydroxylase (AHH) activity, and other coordinately expressed enzymes, and the characteristic toxic responses of ..
  25. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2013
    ..AhR-null and CYP1A1-null mice will be employed to confirm the role of AhR and CYP in the generation of PCB metabolites and effects on ..
  26. Molecular Analysis of Esophageal Cancer Survival
    Matthew Kulke; Fiscal Year: 2007
    ..the association between overall survival and the presence of specific genetic polymorphisms (GSTP1, GSTM1, GSTT1, CYP1A1, CYP3A5, p53, XRCC1 and ERCC2) in patients with esophageal cancer...
  27. c-Myc transcription in intestinal growth, differentiation, and carcinogenesis
    Gregory S Yochum; Fiscal Year: 2012
    ..LoxP technology, making use of a -naphthoflavone-sensitive Cre recombinase under control of the intestine-specific CYP1A1 promoter...
  28. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..Exposure to HAHs highly induces cytochrome P4501A1 (CYP1A1) and notably, ?-3 PUFAs are the preferred endogenous fatty acid substrates for CYP1A1...
  29. Cytochrome P4501A1 and Vascular Injury
    Mary K Walker; Fiscal Year: 2012
    ..is a significant source of ROS and is highly induced in the vasculature by chemicals in TS is cytochrome P4501A1 (CYP1A1)...
  30. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..for the long-standing observation that inflammatory cytokines and lipopolysaccharide suppress AhR-regulated cytochrome P450 1A1/1A2 and decrease capacity of xenobiotic (including clinical drugs) metabolism (J. Biol. Chem. 276,39638)...
  31. CYP1B1 and Retinopathy of Prematurity
    Nader Sheibani; Fiscal Year: 2010
    ..Although lack of CYP1 B1 is shown to influence the function and development of the trabecular meshwork...
  32. Test to Predict Effectiveness of Docetaxel Treatment
    Carol Swartz; Fiscal Year: 2013
    ..The focus of Objective 1 is the development and validation of a CYP1 81 *3 genotype assay using a PCR based Taqman allelic discrimination technique suitable for eventual use in a GLP/..
  33. Polycyclic Aromatic Hydrocarbons And Male Reproductive Health
    HUEIWANG ANNA COOK JENG; Fiscal Year: 2010
    ..characterize coke-oven workers'sperm quality, quantify PAH biomarker levels, and detect allelic variants in CYP1A1 and GSTM1 genes. Urine samples will be collected for determining PAH internal exposure levels...
  34. Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk Factors
    Yvette C Cozier; Fiscal Year: 2012
    ..in the synthesis of sex steroids (CYP17, CYP19), and the metabolism and detoxification of estrogen (COMT, CYP1B1, CYP1A1, ESR1), in relation to sarcoidosis risk...
  35. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..stable transfection of human NAT1 or NAT2 variant alleles into Chinese hamster ovary cells transfected with human CYP1A1 or CYP1B1;determine the relative level of NAT1 and NAT2 expression in normal human mammary tissue as a function of ..
  36. THE NEUROENDOCRINE CONTROL OF REPRODUCTION IN THE HUMAN
    William Francis Crowley; Fiscal Year: 2012
    ..Hypogonadotropic Hypogonadism (nIHH), Kallmann's Syndrome (KS) and Acquired Hypogonadotropic Aypogonadism (AHH)...
  37. Cytochrome-P-450 genes in pathobiology of endometrial cancer
    Rajvir Dahiya; Fiscal Year: 2009
    The main goal of this project is to investigate whether the cytochrome P4501A1 (CYP1A1) and cytochrome P4501B1 (CYP1B1) genes are risk factors for pathobiology of endometrial cancer...
  38. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..ii) To test the hypothesis that humanized CYP1A1 mice [hCYP1A1-Cyp1a1 (-/-)], or hCYP1A1_1A2-Cyp1a1/1a2 (-/-)] mice on will be more tolerant to hyperoxic injury, ..
  39. Toxicological Control Mechanisms of Human CYP1A2
    LINDA QUATTROCHI; Fiscal Year: 2004
    ..CYP 1 A, one of the CYP subfamilies in vertebrates consisting of two members, CYP1A1 and CYP1A2, catalyzes the metabolism of such environmental chemicals as polycyclic aromatic hydrocarbons and ..
  40. Rudi Fasan; Fiscal Year: 2016
    ..In this application, we propose research aimed at developing powerful new methodologies to exploit P450 C-H oxidation catalysis and P450-mediated synthesis for selective transformation of unreactive aliphatic C-H bonds ..
  41. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..g. grilled foods &cigarette smoke. Cytochromes P450 1A1 &1B1 (CYP1A1, CYP1B1) are responsible for the metabolism of numerous PAHs, the prototype of which is benzo[a]pyrene (BaP)...
  42. REGULATION OF POLYCYCLIC AROMATIC HYDROCARBON TOXICITY
    WILLIAM HOUSER; Fiscal Year: 1992
    ..on a detailed analysis of the mechanisms which regulate the expression of an important enzyme activity, aryl hydrocarbon hydroxylase (AHH)...
  43. Roles of pulmonary and hepatic P4501A enzymes in hyperoxic lung injury in mice
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..The specific aims are: (1) to test the hypothesis that hyperoxia induces CYP1A1 and 1A2 gene expression through mechanisms involving transcriptional activation of the CYP1A1 or 1A2 promoter, ..
  44. SILENCING OF CYP1A1 GENE EXPRESSION IN KERATINOCYTES
    Michael Denison; Fiscal Year: 1999
    ..agents, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is the expression of cytochrome P4501A1 (CYP1A1)...
  45. MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER
    Timothy Rebbeck; Fiscal Year: 1999
    ..These genes include cytochromes P450 (e.g. CYP1A1, CYP2D6, and CYP2E1) and the mu or theta classes of the glutathione-S-transferases...
  46. ABNORMAL FETAL DEVELOPMENT DUE TO TOXIC EXPOSURE
    MRINAL SANYAL; Fiscal Year: 1991
    ..g., benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene). Benzo[a]pyrene hydroxylase (Aryl hydrocarbon hydroxylase) and other mixed function oxidase (MFO) enzyme activities are to be measured in human placental tissues ..
  47. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver carcinogens into genotoxic epoxides...
  48. PCBs, CYP1A1 Polymorphism and Breast Cancer Risk in CT
    Tongzhang Zheng; Fiscal Year: 2002
    ..strong inducers of key genes involved in steroid metabolism and xenobiotic metabolism, such as human cytochrome CYP1A1. Recent epidemiological studies suggest that women are at increased risk of breast cancer if they have an elevated ..
  49. ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER
    Mary Wolff; Fiscal Year: 1993
    ..The relationship of breast cancer to genetic polymorphisms in carcinogen metabolizing genes (CYP1A1, CYP1A2, CYP2E1, GST) will be determined...
  50. ENDOMETRIAL CANCER AND CYP1A1, GSTM1 AND POLYMORPHISMS
    Noel Weiss; Fiscal Year: 1999
    ..The genes of interest are: cytochrome P450 1A1 (CYP1A1), glutathione-S-transferases M1 (GSTM1) and T1 (GSTT1), and catechol-O-methyltransferase (COMT)...
  51. RETINOIDS AND THE ARYLHYDROCARBON RECEPTOR PATHWAY
    DIANNE SOPRANO; Fiscal Year: 2003
    ..Preliminary data demonstrate that one non-isoprenoid retinoid, AGN193109, can elevate the level of CYP1A1 mRNA in mouse embryos and Hepa-1c1c7 cells...
  52. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..of a number of genes involved in the biosynthesis and catabolism of estrogens (CYP11a, CYP17, EDH17beta2, CYP1A1, CYP1A2, CYP1B1, COMT), and those for the androgen receptor, estrogen receptor and IGF-I genes are related to the ..
  53. Validation of Biomarkers in Humans Exposed to PAHs
    Qingshan Qu; Fiscal Year: 2004
    ..In addition, the polymorphisms of genes, including CYP1A1, microsomal epoxide hydrolase (mEH), GSTM1, and p53 genes, will be identified to assess gene-environment ..
  54. CYP1A1, estrogen metabolism and ovarian carcinogenesis
    Shuk Mei Ho; Fiscal Year: 2004
    ..Recently, we have demonstrated a) overexpression of CYP1A1 enzyme, but not CYP1B1 enzyme, in epithelial OC specimens, b) increased transcription of CYP1A1 in epithelial OC ..
  55. CYP1A1 and CYP1B1 genes in race-related Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2007
    The main goal of this project is to investigate whether over-expression of cytochrome P450 1A1 (CYP1A1) and cytochrome P4501 B1 (CYP1B1) genes can be risk factors for race-related prostate cancer...
  56. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..Several studies have shown that DNA adducts, p53 mutations, CYP1A1 expression in the lung, and GSTM1 null genotypes are more frequent in females than in males...
  57. CYTOCHROME P450 GENES AND THEIR REGULATION
    Robert Tukey; Fiscal Year: 1999
    ..that when activated in the presence of ligand translocates to nucleus and couples with the nuclear aryl hydrocarbon hydroxylase nuclear translocator (ARNT) protein...
  58. Prevention of colon cancer by an AT2 receptor antagonist
    Masaaki Tamura; Fiscal Year: 2002
    ..Cytochrome P4501A1, 1A2 and 2E1 (CYP1A1, lA2 and 2E1) are major catalysts in the bioactivation of a number of putative colorectal cancer procarcinogens ..
  59. DIOXIN TOXIC EQUIVALENCY FACTORS--BATTELLE MEMORIAL INST
    Milton Hejtmancik; Fiscal Year: 2000
    ..The relative potencies for biochemical endpoints, such as CYP1A1 induction, in the two-year studies are equivalent to the relative potency for carcinogenesis when estimated based ..
  60. ETS Exposure and Genetics: Youth at Risk for CV Disease
    Martha Tingen; Fiscal Year: 2006
    ..Specific candidate genes involved in these biotransformation reactions include CYP1A1, GSTM1, GSTT1, and CYP2A6...
  61. Polycyclic Hydrocarbons and CYP1B1 in Breast Cancer
    Colin Jefcoate; Fiscal Year: 2005
    ..that CYP1B 1 plays a major role in PAH-induced breast cancer, and that the contribution is greater than for CYP1A1 for one or more of the following reasons: (1) CYP1B1 is constitutively expressed in breast epithelia, whereas ..
  62. BAYESIAN BIOMARKER MODELS FOR CANCER GENETICS STUDIES
    SARAH THURSTON; Fiscal Year: 2004
    ..adducts (a biomarker of smoking exposure), and genes associated with adduct formation and DNA repair (including CYP1A1 MSP1, GSTM1 and XRCC1). Currently the study has 2800 subjects, approximately half of whom are cases...
  63. Estrogen Pathway Genes and Association with Prostate Cancer Risk
    Janet Stanford; Fiscal Year: 2009
    ..aromatase (CYP19A1) that converts testosterone to estrogen, and the genes that encode estrogen catabolism enzymes (CYP1A1 and CYP1B1)...
  64. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..focusing on the polymorphic enzymes involved in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
  65. REGULATION OF ARNT FUNCTION BY PHOSPHORYLATION STATUS
    Steven Levine; Fiscal Year: 1999
    ..The AhR-ARNT complex binds DNA regulatory elements upstream of the cytochrome P4501A1 (CYP1A1) gene and activates CYP1A1 expression...
  66. Modulation by dioxin of ovarian estrogen synthesis
    REINHOLD HUTZ; Fiscal Year: 2002
    ..SCC, CYP11A) or aromatase (CYP19) mRNA, protein and activity; and has no effect on estrogen-metabolizing enzymes (CYP1A1, 1B1). Aim (1a). To determine effects of low-dose (environmentally relevant) TCDD on steroidogenic endpoints...
  67. CYP1A1 AS A BIOMARKER OF EXPOSURE AND SUSCEPTIBILITY
    Seymour Garte; Fiscal Year: 1999
    DESCRIPTION (Adapted from the Investigator's Abstract): The focus of this project is the use of CYP1A1 gene to monitor human exposure to aromatic hydrocarbons, and to explore the molecular basis of CYP1A1 polymorphisms as cancer ..
  68. Androgen Pathway Factors and Prostate Cancer
    John Witte; Fiscal Year: 2005
    ..in the following ten androgen pathway candidate genes on prostate cancer risk: 1) CYP3A4; 2) 5a-reductase II; 3) CYP1 7; 4) the Androgen Receptor; 5) Kallikrein 3; 6) 3Beta-hydroxysteroid dehydrogenase II; 7) CYP1 la; 8) CYP19; 9) ..