CYP17A1

Summary

Gene Symbol: CYP17A1
Description: cytochrome P450 family 17 subfamily A member 1
Alias: CPT7, CYP17, P450C17, S17AH, steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, cytochrome P450 17A1, cytochrome P450, family 17, subfamily A, polypeptide 1, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia, cytochrome P450-C17, cytochrome P450c17, cytochrome p450 XVIIA1, steroid 17-alpha-monooxygenase
Species: human

Top Publications

  1. ncbi Genetic polymorphism in CYP17 and breast cancer risk in Japanese women
    Y Miyoshi
    Department of Surgical Oncology, Osaka University Medical School, Suita Shi, Japan
    Eur J Cancer 36:2375-9. 2000
  2. ncbi Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription
    Marion B Sewer
    Department of Biochemistry and Center in Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Endocrinology 143:1280-90. 2002
  3. ncbi SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells
    Natalia Derebecka-Holysz
    Department of Biochemistry and Molecular Biology, Medical University, 6 Swiecickiego St, Poznan, Poland
    Mol Cell Biochem 307:65-71. 2008
  4. ncbi Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1
    Jessica K Wickenheisser
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 18:588-605. 2004
  5. ncbi Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation
    N A Hanley
    Department of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center Dallas, Texas 75390 8857, USA
    Mol Endocrinol 15:57-68. 2001
  6. ncbi CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells
    Marion B Sewer
    School of Biology, Georgia Institute of Technology, Atlanta 30332 0230, USA
    J Biol Chem 278:8106-11. 2003
  7. ncbi Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells
    Iqbal Munir
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocrinology 145:175-83. 2004
  8. pmc Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study
    Aruna V Sarma
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Prostate 68:296-305. 2008
  9. ncbi Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
    Aarti N Urs
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, Georgia 30332 0230, USA
    Endocrinology 147:5249-58. 2006
  10. doi FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells
    Mira Park
    Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463 836, Korea
    Mol Endocrinol 24:1024-36. 2010

Research Grants

  1. VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2014
  2. Nima Sharifi; Fiscal Year: 2016
  3. Richard J Auchus; Fiscal Year: 2016
  4. DAVID FERNANDO ESTRADA; Fiscal Year: 2014
  5. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
  6. Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk Factors
    Yvette C Cozier; Fiscal Year: 2012
  7. Nima Sharifi; Fiscal Year: 2016
  8. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
  9. Angela M Brodie; Fiscal Year: 2014
  10. Emily E Scott; Fiscal Year: 2015

Detail Information

Publications212 found, 100 shown here

  1. ncbi Genetic polymorphism in CYP17 and breast cancer risk in Japanese women
    Y Miyoshi
    Department of Surgical Oncology, Osaka University Medical School, Suita Shi, Japan
    Eur J Cancer 36:2375-9. 2000
    ..to investigate the association of two genetic polymorphisms (1931T/C and 1951G/A) in the promoter region of the CYP17 gene with breast cancer risk in Japanese women...
  2. ncbi Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription
    Marion B Sewer
    Department of Biochemistry and Center in Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Endocrinology 143:1280-90. 2002
    The first 57 bp upstream of the transcription initiation site of the human CYP17 (hCYP17) gene are essential for both basal and cAMP-dependent transcription...
  3. ncbi SMAD3 inhibits SF-1-dependent activation of the CYP17 promoter in H295R cells
    Natalia Derebecka-Holysz
    Department of Biochemistry and Molecular Biology, Medical University, 6 Swiecickiego St, Poznan, Poland
    Mol Cell Biochem 307:65-71. 2008
    b>Cytochrome P450c17, encoded by the CYP17 gene, is a component of 17alpha-hydroxylase/17,20 lyase which catalyses 17alpha-hydroxylation of pregnenolone or progesterone, required for glucocorticosteroid and androgen synthesis...
  4. ncbi Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1
    Jessica K Wickenheisser
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive H166, Hershey, Pennsylvania 17033, USA
    Mol Endocrinol 18:588-605. 2004
    Cytochrome P450 17alpha-hydroxylase (CYP17) gene expression and androgen biosynthesis are persistently elevated in theca cells isolated from ovaries of women with polycystic ovary syndrome (PCOS)...
  5. ncbi Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential interactions in gene regulation
    N A Hanley
    Department of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center Dallas, Texas 75390 8857, USA
    Mol Endocrinol 15:57-68. 2001
    ..In this study, we investigate the regulation of the human CYP17 gene by two orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX1...
  6. ncbi CAMP-dependent protein kinase enhances CYP17 transcription via MKP-1 activation in H295R human adrenocortical cells
    Marion B Sewer
    School of Biology, Georgia Institute of Technology, Atlanta 30332 0230, USA
    J Biol Chem 278:8106-11. 2003
    ..kinase phosphatase-1 (MKP-1), a nuclear dual-specificity phosphatase, in the transcriptional activation of human CYP17 (hCYP17) in H295R human adrenocortical cells is established...
  7. ncbi Insulin augmentation of 17alpha-hydroxylase activity is mediated by phosphatidyl inositol 3-kinase but not extracellular signal-regulated kinase-1/2 in human ovarian theca cells
    Iqbal Munir
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocrinology 145:175-83. 2004
    ..Insulin alone had no effect on 17alpha-hydroxylase activity or CYP17 mRNA expression but required costimulation with forskolin...
  8. pmc Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study
    Aruna V Sarma
    Department of Urology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Prostate 68:296-305. 2008
    ....
  9. ncbi Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1
    Aarti N Urs
    School of Biology, Georgia Institute of Technology, 310 Ferst Drive, Atlanta, Georgia 30332 0230, USA
    Endocrinology 147:5249-58. 2006
    ..ligands for SF1 and characterize their functional significance in mediating cAMP-dependent transcription of human CYP17. Using tandem mass spectrometry, we show that in H295R adrenocortical cells, SF1 is bound to sphingosine (SPH) and ..
  10. doi FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells
    Mira Park
    Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463 836, Korea
    Mol Endocrinol 24:1024-36. 2010
    ..granulosa cells and that FOXL2 negatively regulates the transcriptional activation of a steroidogenic enzyme, CYP17, by SF-1...
  11. ncbi Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency
    T Imai
    Department of Biochemistry and Obstetrics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 268:19681-9. 1993
    Enzymatically active human 17 alpha-hydroxylase cytochrome P450 (P450c17) has been expressed in and purified from Escherichia coli...
  12. ncbi A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiency
    H Yamaguchi
    Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    J Clin Endocrinol Metab 82:1934-8. 1997
    ..Using DNA sequencing analysis of the 17alpha-hydroxylase (CYP17) gene from a Japanese patient with 17OHD, we identified a new type of genetic abnormality in this disease, a G to ..
  13. ncbi The genetic and functional basis of isolated 17,20-lyase deficiency
    D H Geller
    Department of Pediatrics, University of California San Francisco 94143 0978, USA
    Nat Genet 17:201-5. 1997
    ..because 17 alpha-hydroxylase and 17,20-lyase activities are catalyzed by a single enzyme, microsomal cytochrome P450c17, and because the index case of apparent isolated 17,20-lyase deficiency had combined deficiencies of both ..
  14. ncbi A new compound heterozygous mutation (W17X, 436 + 5G --> T) in the cytochrome P450c17 gene causes 17 alpha-hydroxylase/17,20-lyase deficiency
    Y Suzuki
    Department of Pediatrics, Gunma University School of Medicine, Japan
    J Clin Endocrinol Metab 83:199-202. 1998
    A genetic disorder in cytochrome P450c17 results in 17 alpha-hydroxylase/17,20-lyase deficiency. In the present study, a Japanese patient with 17 alpha-hydroxylase/17,20-lyase deficiency underwent molecular analysis...
  15. ncbi 17alpha-hydroxylase/17,20-lyase deficiency as a model to study enzymatic activity regulation: role of phosphorylation
    A Biason-Lauber
    Department of Pediatrics, University of Zurich, Switzerland
    J Clin Endocrinol Metab 85:1226-31. 2000
    Cytochrome P450 17alpha-hydroxylase (CYP17) is a single gene-encoded protein with two activities: 17alpha-hydroxylase and 17,20-lyase. The two catalytic activities are differentially regulated in health and disease...
  16. ncbi Steroid metabolism gene CYP17 polymorphism and the development of breast cancer
    K Mitrunen
    Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki
    Cancer Epidemiol Biomarkers Prev 9:1343-8. 2000
    The potential role of the polymorphism in the CYP17 gene was evaluated in a case-control study with 483 incident breast cancer patients and 482 population controls, all of homogenous Finnish origin...
  17. ncbi Risk of endometrial cancer and estrogen replacement therapy history by CYP17 genotype
    R McKean-Cowdin
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Center, Los Angeles 90033 0800, USA
    Cancer Res 61:848-9. 2001
    ..We examined the association between endometrial cancer risk and estrogen replacement therapy (ERT) by CYP17 genotype using 51 incident cases and 391 randomly selected controls from a multiethnic cohort in Hawaii and Los ..
  18. ncbi A polymorphism in CYP17 and endometrial cancer risk
    C A Haiman
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Res 61:3955-60. 2001
    Among women, the A2 allele of CYP17 has been associated with elevated levels of endogenous steroid hormones; however, it does not seem to be a strong independent risk factor for breast cancer...
  19. ncbi Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency
    M K Gupta
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Clin Endocrinol Metab 86:4416-23. 2001
    The cytochrome P450c17 enzyme system performs both the 17alpha-hydroxylase and 17,20-lyase reactions in the human adrenal glands and gonads...
  20. ncbi CYP gene polymorphisms and early menarche
    J Lai
    Centre for Research in Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario, M5G 1N8, Canada
    Mol Genet Metab 74:449-57. 2001
    ..We investigated whether polymorphisms of the CYP3A4, CYP17, CYP1B1, and CYP1A2 genes predict the age at onset of menarche...
  21. ncbi The CYP17 MspA1 polymorphism and breast cancer risk: a meta-analysis
    Zheng Ye
    Bioinformatics Group, Centre for Molecular Genetics and Toxicology, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    Mutagenesis 17:119-26. 2002
    ..The CYP17 gene encodes P450c17alpha, an enzyme that is involved in the metabolism of steroid hormones...
  22. ncbi Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer
    Elizabeth I O Garner
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cancer Res 62:3058-62. 2002
    Because some studies have linked polymorphic variants of the estrogen-metabolizing genes CYP17 and catechol O-methyl transferase (COMT) with risk for hormonally related cancers, we sought to determine whether selected polymorphisms of ..
  23. ncbi Relationship between serum hormone concentrations, reproductive history, alcohol consumption and genetic polymorphisms in pre-menopausal women
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Bethesda, MD 20852 7234, USA
    Int J Cancer 102:172-8. 2002
    ..Genotypes for CYP11A 5'UTR(tttta)n, CYP17 5'-UTR -34 T>C, CYP19 IVS4(ttta)n, CYP1B1 (L432V and S453N) and COMT (V158M) were determined from genomic DNA ..
  24. ncbi Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency
    Erica L T Van Den Akker
    Department of Pediatrics, Division of Endocrinology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 87:5714-21. 2002
    The microsomal enzyme cytochrome P450c17 is an important regulator of steroidogenesis. The enzyme has two functions: 17alpha-hydroxylase and 17,20-lyase activities...
  25. ncbi Estrogen-metabolizing gene polymorphisms, but not estrogen receptor-alpha gene polymorphisms, are associated with the onset of menarche in healthy postmenopausal Japanese women
    Itsuo Gorai
    Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    J Clin Endocrinol Metab 88:799-803. 2003
    ..assays were used to determine estrogen receptor-alpha: PvuII, XbaI, and estrogen-metabolizing enzymes; CYP17, estrogen biosynthesis (high activity, A2/A2, CYP1A1), hydroxylation (high inducibility, vt/vt, and COMT), ..
  26. ncbi HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore
    Anna H Wu
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Int J Cancer 104:450-7. 2003
    ..Chinese Health Study Cohort, the relationships between polymorphisms in 2 genes involved in estrogen metabolism, CYP17 and HSD17B1, and the risk of breast cancer...
  27. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 5:R45-51. 2003
    Findings from previous studies regarding the association between the CYP17 genotype and breast cancer are inconsistent...
  28. ncbi CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding
    Daniel P Sherbet
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Biol Chem 278:48563-9. 2003
    b>Cytochrome p450c17 (CYP17) converts the C21 steroids pregnenolone and progesterone to the C19 androgen precursors dehydroepiandrosterone (DHEA) and androstenedione, respectively, via sequential 17alpha-hydroxylase and 17,20-lyase ..
  29. ncbi [Relation between single nucleotide polymorphism in estrogen-metabolizing genes COMT, CYP17 and breast cancer risk among Chinese women]
    Wen Tan
    Department of Etiology and Carcinogenesis, Cancer Institute Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 25:453-6. 2003
    To test the hypothesis whether polymorphism in estrogen-metabolizing genes, COMT and CYP17, impacts on the risk of breast cancer among Chinese women.
  30. ncbi Association of CYP17, CYP19, CYP1B1, and COMT polymorphisms with serum and urinary sex hormone concentrations in postmenopausal women
    Shelley S Tworoger
    The Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington, USA
    Cancer Epidemiol Biomarkers Prev 13:94-101. 2004
    ..Several genetic polymorphisms that may influence sex hormone concentrations have been identified, including CYP17 (5'-untranslated region T-->C), CYP19 [intron 4 (TTTA)(n = 7-13) and a 3-bp deletion (-3)], CYP1B1 (Val(432)Leu)..
  31. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  32. ncbi Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria
    Cancer 101:264-9. 2004
    ..In these candidate genes, no critical combination of single-nucleotide polymorphisms (SNPs) for assessing breast carcinoma risk has been reported to date...
  33. ncbi CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    Am J Epidemiol 160:729-40. 2004
    The cytochrome P-450c17alpha (CYP17 ) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17alpha, which functions at key branch points in steroid hormone biosynthesis...
  34. ncbi The cationic charges on Arg347, Arg358 and Arg449 of human cytochrome P450c17 (CYP17) are essential for the enzyme's cytochrome b5-dependent acyl-carbon cleavage activities
    Peter Lee-Robichaud
    Department of Chemistry, Centre for Chemical Biology, University of Sheffield, Sheffield S3 7HF, UK
    J Steroid Biochem Mol Biol 92:119-30. 2004
    CYP17 (17alpha-hydroxylase-17,20-lyase; also P450c17 or P450(17alpha)) catalyses the17alpha-hydroxylation of progestogens and the subsequent acyl-carbon cleavage of the 17alpha-hydroxylated products (lyase activity) in the biosynthesis ..
  35. ncbi CYP17 and SULT1A1 gene polymorphisms in Indian breast cancer
    Priya Chacko
    Division of Molecular Medicine, Drug Development and Chemoinformatics, Regional Cancer Centre, Thiruvananthapuram 695011, Kerala State, India
    Breast Cancer 11:380-8. 2004
    ..The CYP17 and SULT1A1 genes encode for two enzymes involved in hormone biosynthesis and metabolism...
  36. ncbi Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations
    Tasneem Asghar
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    Gynecol Endocrinol 20:59-63. 2005
    ..One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays a vital role in steroid biosynthesis in the ovary...
  37. pmc CYP17 5'-UTR MspA1 polymorphism and the risk of premenopausal breast cancer in a German population-based case-control study
    Emaculate Verla-Tebit
    Division of Clinical Epidemiology, German Cancer Research Center, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R455-64. 2005
    Studies on the association between the cytochrome P450c17alpha gene (CYP17) 5'-untranslated region MspA1 genetic polymorphism and breast cancer risk have yielded inconsistent results...
  38. ncbi Human cytochrome b5 requires residues E48 and E49 to stimulate the 17,20-lyase activity of cytochrome P450c17
    Jacqueline L Naffin-Olivos
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8857, USA
    Biochemistry 45:755-62. 2006
    b>Cytochrome P450c17 (CYP17) catalyzes both the 17alpha-hydroxylase and 17,20-lyase reactions in human steroid biosynthesis...
  39. ncbi Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review
    Sara H Olson
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Epidemiol 165:235-45. 2007
    ..Little or no association was found between genotypes of the cytochrome P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly) and levels of progesterone, ..
  40. ncbi CYP17 gene polymorphism and its association with high-risk north Indian breast cancer patients
    Anurupa Chakraborty
    Institute of Pathology, Safdarjang Hospital Campus, New Delhi, India
    J Hum Genet 52:159-65. 2007
    A single T > C change at the 5' promoter region of the CYP17 gene is reported to be associated with increased risk of breast cancer. This study evaluates the influence of genetic polymorphism of CYP17 on breast cancer susceptibility...
  41. doi Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project
    Yu Chen
    Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Carcinogenesis 29:766-71. 2008
    ..We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and ..
  42. doi Metabolic evidence for impaired 17alpha-hydroxylase activity in a kindred bearing the E305G mutation for isolate 17,20-lyase activity
    Dov Tiosano
    Pediatric Endocrinology, Metabolic Biochemistry Laboratory and Genetics Institute, Rambam Medical Center, Meyer Children s Hospital, Technion Israel Institute of Technology, 9602 Haifa, Israel
    Eur J Endocrinol 158:385-92. 2008
    The CYP17A1 gene encodes many enzymatic reactions including 17alpha-hydroxylase and 17,20-lyase activities...
  43. ncbi Novel mutation in cytochrome P450c17 causes complete combined 17alpha-hydroxylase/17,20-lyase deficiency
    Amrit Bhangoo
    Division of Pediatric Endocrinology, Infants and Children s Hospital of Brooklyn at Maimonides, Brooklyn, NY, USA
    J Pediatr Endocrinol Metab 21:185-90. 2008
    b>Cytochrome P450c17 (CYP17) has two principal enzyme activities, 17alpha-hydroxylase and 17,20-lyase, which are required for cortisol and androgen biosynthesis, respectively...
  44. doi Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women
    Lina Zhang
    Departments of Breast Oncology Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China
    Breast Cancer Res Treat 114:327-38. 2009
    ..polymorphisms in the regulatory regions of ER-alpha (rs3798577) and other two estrogen-metabolizing enzyme genes CYP17 (rs743572) and CYP19 (rs10046) among 300 breast cancer cases and 390 controls in a Chinese population...
  45. ncbi Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization
    T A Pechurskaya
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Belarus
    Biochemistry (Mosc) 73:806-11. 2008
    To engineer a "soluble" form of membrane-bound cytochrome P45017alpha (CYP17)--a key enzyme in steroid hormone biosynthesis--in the present work we have built a computer model of the tertiary structure of the hemeprotein, identified the ..
  46. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1)..
  47. doi Steroid 17alpha-hydroxylase deficiency: functional characterization of four mutations (A174E, V178D, R440C, L465P) in the CYP17A1 gene
    Vivek Dhir
    Centre for Endocrinology, Diabetes and Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Institute of Biomedical Research, Wolfson Drive, Birmingham, United Kingdom
    J Clin Endocrinol Metab 94:3058-64. 2009
    Steroid 17alpha-hydroxylase (CYP17A1, alias P450c17) deficiency (17OHD) is a rare form of congenital adrenal hyperplasia. The CYP17A1 enzyme catalyzes two distinct reactions, 17alpha-hydroxylase and 17,20-lyase activities.
  48. doi No association between CYP17 T-34C polymorphism and breast cancer risk: a meta-analysis involving 58,814 subjects
    Lei Yao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 200433 Shanghai, People s Republic of China
    Breast Cancer Res Treat 122:221-7. 2010
    ..To date, many articles have evaluated the association between Cytochrome P450c17 (CYP17) T-34C polymorphism and breast cancer risk. However, the results remain inconclusive...
  49. doi Factors influencing the association between CYP17 T34C polymorphism and the risk of breast cancer: meta-regression and subgroup analysis
    Yun Chen
    Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, China
    Breast Cancer Res Treat 122:471-81. 2010
    A number of studies have been investigated the association between CYP17 T34C polymorphism and the risk of breast cancer; the results of these studies are inconsistent, however...
  50. doi A single amino acid residue, Ala 105, confers 16alpha-hydroxylase activity to human cytochrome P450 17alpha-hydroxylase/17,20 lyase
    Amanda C Swart
    Department of Biochemistry, University of Stellenbosch, Stellenbosch 7600, South Africa
    J Steroid Biochem Mol Biol 119:112-20. 2010
    In adrenal steroidogenesis, CYP17 catalyses the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17,20-lyase reaction, yielding adrenal androgens...
  51. doi Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
    Johannes Hofland
    Departments of Internal Medicine, Urology, and Pathology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Cancer Res 70:1256-64. 2010
    ..Simultaneous but low expression of the enzymes CYP17A1 and HSD3B1, essential for the synthesis of androgens from pregnenolone, could be detected in 19 of 88 patient ..
  52. doi Clinical, genetic and functional characteristics of three novel CYP17A1 mutations causing combined 17alpha-hydroxylase/17,20-lyase deficiency
    S Rosa
    University Children s Hospital, Zurich, Switzerland
    Horm Res Paediatr 73:198-204. 2010
    b>P450c17 has two distinct activities: 17alpha-hydroxylase activity and 17,20-lyase activity. Combined 17alpha-hydroxylase/17,20-lyase deficiency leads to a severe defect in the production of cortisol and sex steroids...
  53. doi Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population
    Kyung Won Hong
    Department of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul, Korea
    J Hum Genet 55:336-41. 2010
    ..Four loci-ATP2B1 (ATPase, Ca(++) transporting, plasma membrane 1), CSK (c-src tyrosine kinase), CYP17A1 (cytochrome P450 17A1) and PLEKHA7 (pleckstrin homology domain-containing family A member 7)-were associated with blood pressure ..
  54. doi Blood pressure and hypertension are associated with 7 loci in the Japanese population
    Fumihiko Takeuchi
    Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Circulation 121:2302-9. 2010
    ....
  55. doi Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy
    Shozeb M Haider
    CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Mol Biol 400:1078-98. 2010
    A molecular model for the P450 enzyme cytochrome P450 C17 (CYP17) is presented based on sequence alignments of multiple template structures and homology modeling...
  56. ncbi Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21
    J Picado-Leonard
    Department of Pediatrics, University of California, San Francisco 94143
    DNA 6:439-48. 1987
    b>P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of steroid hormones...
  57. ncbi Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates
    H S Feigelson
    American Cancer Society, National Home Office, Atlanta, Georgia 30329 4251, USA
    Cancer Res 61:785-9. 2001
    ..a nested case-control study to evaluate whether polymorphisms in two genes involved in estrogen metabolism, CYP17 and HSD17B1, were useful in developing a breast cancer risk model that could help discriminate women who are at ..
  58. ncbi Association between the T27C polymorphism in the cytochrome P450 c17alpha (CYP17) gene and risk factors for breast cancer
    Chi Chen Hong
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Breast Cancer Res Treat 88:217-30. 2004
    ..A T27C polymorphism (alleles A1 and A2, respectively) in the 5' promoter region of CYP17 may be associated with elevated sex hormone levels...
  59. ncbi CYP17 promoter polymorphism and breast cancer in Australian women under age forty years
    A B Spurdle
    Cancer Unit, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Australia
    J Natl Cancer Inst 92:1674-81. 2000
    ..hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene...
  60. pmc CYP17 promoter polymorphism and breast cancer risk in males and females in relation to BRCA2 status
    K Gudmundsdottir
    Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, 125 Reykjavik, Iceland
    Br J Cancer 88:933-6. 2003
    A T-C polymorphism in the promoter region of the CYP17 gene has been associated with male and female breast cancer risk as well as early-onset familial breast cancer...
  61. ncbi [Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer]
    V V Artamonov
    Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, 115478 Russia
    Mol Biol (Mosk) 37:975-82. 2003
    Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC)...
  62. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
    Because CYP17 can influence the degree of exposure of breast tissues to oestrogen, the interaction between polymorphisms in this gene and hormonal risk factors is of particular interest...
  63. ncbi Ovine steroid 17alpha-hydroxylase cytochrome P450: characteristics of the hydroxylase and lyase activities of the adrenal cortex enzyme
    Pieter Swart
    Department of Biochemistry, University of Stellenbosch, South Africa
    Arch Biochem Biophys 409:145-52. 2003
    The steroid 17-hydroxylase cytochrome P450 (CYP17) found in mammalian adrenal and gonadal tissues typically exhibits not only steroid 17-hydroxylase activity but also C-17,20-lyase activity...
  64. ncbi Demethylation of specific sites in the 5'-flanking region of the CYP17 genes when bovine adrenocortical cells are placed in culture
    P J Hornsby
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912
    DNA Cell Biol 11:385-95. 1992
    ..0 kb (H1), -1.8 kb (H2), and -2.3 kb (H4) in CYP17A1 and CYP17A2 and at -0.7 kb (H0) in CYP17A3...
  65. ncbi Mutually exclusive interactions of two nuclear orphan receptors determine activity of a cyclic adenosine 3',5'-monophosphate-responsive sequence in the bovine CYP17 gene
    M Bakke
    Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden
    Mol Endocrinol 9:327-39. 1995
    ACTH-dependent transcriptional activation of the bovine CYP17 gene (the gene encoding cytochrome P450 steroid 17 alpha-hydroxylase) involves two cAMP-responsive sequences (CRS1 and CRS2) located in the promoter region...
  66. doi A unique exonic splicing mutation in the CYP17A1 gene as the cause for steroid 17{alpha}-hydroxylase deficiency
    Jie Qiao
    Department of Endocrinology, Shanghai Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, 369 Zhizaoju Road, Shanghai 200011, People s Republic of China
    Eur J Endocrinol 164:627-33. 2011
    17α-Hydroxylase/17,20-lyase deficiency (17OHD) caused by a mutation in the CYP17A1 gene is characterized by hypertension, hypokalemia, and abnormal development of the genitalia...
  67. doi CYP17, catechol-o-methyltransferase, and glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on Prince Edward Island
    Alastair E Cribb
    Atlantic Centre for Comparative Biomedical Research, University of Prince Edward Island, Charlottetown, PE, Canada
    Breast J 17:24-31. 2011
    ..Genetic polymorphisms in CYP17, GSTM1, and catechol-O-methyltransferase (COMT) were not associated with a general increase in breast cancer risk...
  68. ncbi Effects of compatible solutes on mammalian cytochrome P450 stability
    W N Kühn-Velten
    Labor für Biochemische Endokrinologie, Frauenklinik und Institut für Physiologische Chemie, Heinrich Heine Universitat, Dusseldorf, Bundesrepublik Deutschland
    Z Naturforsch C 52:132-5. 1997
    The sensitivity of pig cytochrome P450c17 (CYP17), an endoplasmic reticulum membrane-bound enzyme, towards heat denaturation (48 degrees C) was measured by the P450-to-P420 spectral transition indicating conformational labilization of the ..
  69. ncbi Abnormalities of sex differentiation
    H Nawata
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Res 46:15-9. 1996
    ..Many factors involved in this cascade have been identified. Here we focus on DAX-1, androgen receptor and cytochrome P450c17, and discuss their functions in sex differentiation...
  70. ncbi [Genetic aspects of polycystic ovary syndrome]
    Lucjusz Jakubowski
    Department of Genetics, Polish Mother s Memorial Hospital Research Institute, 93 338 Lodz, Poland
    Endokrynol Pol 56:285-93. 2005
    ..pathways have been tested include genes involved in steroid hormone biosynthesis and metabolism (StAR, CYP11, CYP17, CYP19 HSD17B1-3, HSD3B1-2), gonadotropin and gonadal hormones action (ACTR1, ACTR2A-B, FS, INHA, INHBA-B, INHC, ..
  71. doi Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Nutr Cancer 62:466-75. 2010
    We tested the hypothesis that polymorphisms in cytochrome P450c17alpha (CYP17), aromatase (CYP19), 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and sex hormone-binding globulin (SHBG) genes may modify the association between ..
  72. ncbi Organ-specific and non-organ-specific autoantibodies in children and young adults with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
    R Perniola
    Paediatric Unit, Vito Fazzi Regional Hospital, Lecce, Italy
    Eur J Endocrinol 143:497-503. 2000
    ....
  73. ncbi Down-regulation of steroidogenic cytochrome P450XVII in cryptorchid rat testes
    N Kühn-Velten
    Institut für Physiologische Chemie II, Heinrich Heine Universitat, Dusseldorf, Germany
    Horm Metab Res 22:528-32. 1990
    ....
  74. ncbi Expression of three negative regulators of CYP17 gene transcription in adrenocortical cells
    T Lehmann
    Department of Biochemistry and Molecular Biology, University of Medical Sciences, Poznan, Poland
    Endocr Res 26:1019-26. 2000
    The expression of negative regulators of CYP17 gene expression: DAX-1, COUP-TF and N-CoR was investigated in bovine adrenocortical cells in primary culture...
  75. pmc Nonhuman primates as models for human adrenal androgen production: function and dysfunction
    D H Abbott
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Rev Endocr Metab Disord 10:33-42. 2009
    ..primate), and further consider these events in terms of the corresponding developmental changes in expression of CYP17, HSD3B2 and CYB5 in the ZR...
  76. ncbi Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system
    N A Compagnone
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 94143, USA
    Endocrinology 136:5212-23. 1995
    ..However, cytochrome P450c17, which has 17-hydroxylase and 17,20-lyase activity and is thought to be required for the synthesis of ..
  77. ncbi Concentrations of steroids and expression of messenger RNA for steroidogenic enzymes and gonadotropin receptors in bovine ovarian follicles of first and second waves and changes in second wave follicles after pulsatile LH infusion
    M Manikkam
    Department of Animal Sciences, University of Missouri Columbia, Columbia, MO 65211 5300, USA
    Anim Reprod Sci 67:189-203. 2001
    ..of mRNA for cytochrome P450 cholesterol side-chain cleavage (P450scc), cytochrome P450 17alpha-hydroxylase (P450c17), cytochrome P450 aromatase (P450arom), 3beta-hydroxysteroid dehydrogenase Delta(4), Delta(5) isomerase (3beta-..
  78. ncbi Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression
    X Li
    Department of Physiology and Biophysics, University of Illinois, Chicago 60612 7342, USA
    Endocrinology 136:3519-26. 1995
    ..biosynthesis in Leydig cells is dependent on the action of 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 (P450c17), which is encoded by the Cyp17 gene...
  79. ncbi Genetic analysis of the cytochrome P-450c17alpha (CYP17) and aldosterone synthase (CYP11B2) in Japanese patients with 17alpha-hydroxylase deficiency
    Y Takeda
    Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Third Department of Internal Medicine, Fukui Medical School, Fukui and Koseiren Takaoka Hospital, Takaoka, Japan
    Clin Endocrinol (Oxf) 54:751-8. 2001
    ..two Japanese patients with 17alpha-hydroxylase deficiency, we analysed the 17alpha-hydroxylase/17,20-lyase gene (CYP17)...
  80. ncbi Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells
    Ying Liu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road Northwest, Washington, D C 20057, USA
    Mol Endocrinol 19:1918-31. 2005
    Cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) is a microsomal enzyme catalyzing two distinct activities, 17alpha-hydroxylase and 17,20-lyase, essential for the biosynthesis of adrenal and gonadal steroids...
  81. doi 17-Hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites
    Cedric H L Shackleton
    Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Steroids 73:652-6. 2008
    ..We questioned whether it could be CYP17, the 17-hydroxylase/17,20-lyase utilized in androgen synthesis...
  82. ncbi The role of tumor necrosis factor-alpha in the regulation of mouse Leydig cell steroidogenesis
    Y Xiong
    Department of Physiology and Biophysics, University of Illinois, Chicago 60612 7342
    Endocrinology 132:2438-44. 1993
    ..production, as well as cholesterol side-chain cleavage enzyme (P450scc) and 17 alpha-hydroxylase/C17,20 lyase (P450c17), were investigated. Treatment of Leydig cells with 0.1, 1.0, and 10...
  83. ncbi Functional expression of recombinant spiny dogfish shark (Squalus acanthias) cytochrome P450c17 (17 alpha-hydroxylase/C17,20-lyase) in yeast (Pichia pastoris)
    J M Trant
    Department of Zoology and Physiology, Louisiana State University, Baton Rouge 70803, USA
    Arch Biochem Biophys 326:8-14. 1996
    The cDNA encoding the spiny dogfish shark (Squalus acanthias) testicular form of cytochrome P450c17 (CYP17) was used to direct the heterologous expression of a functional enzyme in yeast (Pichia pastoris)...
  84. ncbi In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?
    Rocío F Cantón
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Yalelaan 2, 3508 TD, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 216:274-81. 2006
    ..analogues), TBBPA and brominated phenols (BPs) on the combined 17alpha-hydroxylase and 17,20-lyase activities of CYP17. CYP17 enzyme catalyzes an important step in sex steroidogenesis and is responsible for the biosynthesis of ..
  85. ncbi The role of cytochrome b5 in the biosynthesis of androgens by human P450c17
    M Katagiri
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146
    Arch Biochem Biophys 317:343-7. 1995
    Human cytochrome b5 has a profound effect on the 17,20-lyase activities catalyzed by purified, human cytochrome P450c17. It enhances the conversion of 17 alpha-hydroxypregnenolone to dehydroepiandrosterone by 13-fold and the conversion of ..
  86. ncbi Comparison of the 17 alpha-hydroxylase/C17,20-lyase activities of porcine, guinea pig and bovine P450c17 using purified recombinant fusion proteins containing P450c17 linked to NADPH-P450 reductase
    Manjunath S Shet
    Purdue Pharma LP, Department of Pharmocokinetics and Drug Metabolism, Stamford, Connecticut, USA
    Drug Metab Rev 39:289-307. 2007
    The cDNAs for cytochrome P450c17 (P450c17) of three species, pig, guinea pig, and cow, representing three families of mammals (suidae, procaviidae, and bovidae, respectively) were each engineered into an expression plasmid (pCWori+)...
  87. ncbi Regulation of cytochrome b5 gene transcription by Sp3, GATA-6, and steroidogenic factor 1 in human adrenal NCI-H295A cells
    Ningwu Huang
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0978, USA
    Mol Endocrinol 19:2020-34. 2005
    Sex steroid synthesis requires the 17,20 lyase activity of P450c17, which is enhanced by cytochrome b5, acting as an allosteric factor to promote association of P450c17 with its electron donor, P450 oxidoreductase...
  88. ncbi A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21
    Calin Aurel Dragan
    Department of Biochemistry, Saarland University D 66041 Saarbrücken, Germany
    J Enzyme Inhib Med Chem 21:547-56. 2006
    Human steroid 21-hydroxylase (CYP21) and steroid 17alpha-hydroxylase/17,20-lyase (CYP17) are two closely related cytochrome P450 enzymes involved in the steroidogenesis of glucocorticoids, mineralocorticoids, and sex hormones, ..
  89. ncbi Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo
    D S Keeney
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Endocrinology 136:4872-9. 1995
    ..in adult mice and rats, and this is explained, in part, by the absence of 17 alpha-hydroxylase cytochrome P450 (P450c17) in adrenal glands of these rodents...
  90. ncbi Baboon cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17)
    Amanda C Swart
    Department of Biochemistry, University of Stellenbosch, South Africa Department of Reproductive and Developmental Sciences, University of Edinburgh Medical School, Scotland, UK
    Eur J Biochem 269:5608-16. 2002
    Human cytochrome P450 17alpha-hydroxylase (CYP17) catalyses not only the 17alpha-hydroxlation of pregnenolone and progesterone and the C17,20-side chain cleavage (lyase) of 17alpha-hydroxypregnenolone, necessary for the biosynthesis of ..
  91. doi P450C17 (CYP17) deficiency in native Mexican patient with a novel CYP17A1 mutation
    Edgar G Durán Pérez
    Department of Endocrinology, National Autonomous of Mexico, Mexico City, Mexico
    Endocr Pract 17:99-103. 2011
    To report a case of congenital adrenal hyperplasia due to CYP17 deficiency caused by a novel CYP17A1 mutation.
  92. ncbi Dehydroepiandrosterone: biosynthesis and metabolism in the brain
    I H Zwain
    Department of Reproductive Medicine, University of California San Diego School of Medicine, La Jolla 92093 0633, USA
    Endocrinology 140:880-7. 1999
    ..have, therefore, initiated pilot experiments to explore gene expression of cytochrome P450 17alpha-hydroxylase (P450c17), the key steroidogenic enzyme for androgen synthesis, and evaluate DHEA production by highly purified astrocytes,..
  93. ncbi Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line
    Paul G Farnworth
    Prince Henry s Institute, P O Box 5152, Clayton, Victoria 3168, Australia
    Endocrinology 147:3462-71. 2006
    ..AC) cell line by examining the effects of inhibins A and B on cytochrome P450 17alpha-hydroxylase 17,20-lyase (Cyp17) expression and 17alpha-hydroxylase activity, measured by progesterone 17alpha-hydroxylation, in the absence and ..
  94. doi Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay
    Tannia Gracia
    Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Environ Sci Pollut Res Int 15:332-43. 2008
    ..After exposing H295R cells to extracts of water, the expression of four steroidogenic genes and the production of three steroid hormones were measured...
  95. doi Androgen synthesis in adrenarche
    Walter L Miller
    Department of Pediatrics, University of California, Room 672 S, San Francisco, CA 94143 0978, USA
    Rev Endocr Metab Disord 10:3-17. 2009
    ..Qualitative regulation, which determines the type of steroid produced in a cell, is principally at the level of P450c17 (CYP17)...
  96. ncbi Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities
    C M Jenkins
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146
    J Biol Chem 269:27401-8. 1994
    ..the 17 alpha-hydroxylase activities of heterologously expressed bovine 17 alpha-hydroxylase cytochrome P450 (P450c17)...
  97. ncbi P450c17 mutations R347H and R358Q selectively disrupt 17,20-lyase activity by disrupting interactions with P450 oxidoreductase and cytochrome b5
    D H Geller
    Department of Pediatrics, University of California, San Francisco 94143 0978, USA
    Mol Endocrinol 13:167-75. 1999
    b>Cytochrome P450c17 catalyzes steroid 17alpha-hydroxylase and 17,20-lyase activities and hence is a key enzyme in the production of human glucocorticoids and sex steroids...
  98. pmc Deletion of the mouse P450c17 gene causes early embryonic lethality
    Susanna R Bair
    Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, and The Metabolic Research Unit, University of California, San Francisco, 94143, USA
    Mol Cell Biol 24:5383-90. 2004
    ..The synthesis of DHEA and sex steroids, but not mouse glucocorticoids and mineralocorticoids, requires P450c17, which catalyzes both 17 alpha-hydroxylase and 17,20-lyase activities...
  99. ncbi Seasonal changes in spermatogenesis and immunolocalization of cytochrome P450 17alpha-hydroxylase/c17-20 lyase and cytochrome P450 aromatase in the wild male ground squirrel (Citellus dauricus Brandt)
    Haolin Zhang
    College of Biological Science and Technology, Beijing Forestry University, Beijing, China
    J Reprod Dev 56:297-302. 2010
    The purpose of this study was to investigate seasonal changes of spermatogenesis and the cellular localization of P450c17 and P450arom in wild male ground squirrels during the breeding and non-breeding seasons...
  100. ncbi Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens
    J E Nestler
    Department of Internal Medicine, Medical College of Virginia Virginia Commonwealth University, Richmond 23298, USA
    J Clin Endocrinol Metab 82:4075-9. 1997
    ..and this study was conducted to test the hypothesis that hyperinsulinemia stimulates ovarian cytochrome P450c17 alpha activity in nonobese women with PCOS, thereby increasing serum androgen concentrations...
  101. ncbi Immunolocalization of steroidogenic enzymes in the corpus luteum and placenta of the Japanese black bear, Ursus thibetanus japonicus, during pregnancy
    T Tsubota
    Laboratory of Theriogenology, Faculty of Agriculture, Gifu University, Gifu 501 11, Japan
    Reproduction 121:587-94. 2001
    ..cytochrome P450 (P450scc), 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17alpha-hydroxylase cytochrome P450 (P450c17) and aromatase cytochrome P450 (P450arom) by the avidin-biotin-peroxidase complex method using polyclonal ..

Research Grants69

  1. VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2014
    ..It may also be relevant to state here that in another project, a CYP17 inhibitor /androgen receptor modulator, VN/124-1 (now called TOK-001) invented by the PI of this application ..
  2. Nima Sharifi; Fiscal Year: 2016
    ..The survival benefit conferred by abiraterone acetate, which blocks CYP17A1 and was approved by the United States Food and Drug Administration in April 2011 for the treatment of CRPC, is ..
  3. Richard J Auchus; Fiscal Year: 2016
    ..derive from 21-carbon steroids via sequential 17[unreadable]- hydroxylase and 17,20-lyase activities of cytochrome P450c17 (CYP17A1)...
  4. DAVID FERNANDO ESTRADA; Fiscal Year: 2014
    ..Our immediate objective is to apply 2D solution NMR to study ligand binding in the human androgen-producing cytochrome P450 17A1 (CYP17A1) to direct drug design efforts. Since >240,000 U.S...
  5. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ..SNPs in sex-hormone genes of interest include estrogen receptors (ESR), cytochrome P450 17A1 (CYP17A1), sex-hormone binding globulin (SHBG) and catechol-O-methyltransferase (COMT), and in immune/..
  6. Sarcoidosis in U.S. Black Women: Genetic and Non-genetic Risk Factors
    Yvette C Cozier; Fiscal Year: 2012
    ..alleles of genes involved in sex hormone metabolism, including those involved in the synthesis of sex steroids (CYP17, CYP19), and the metabolism and detoxification of estrogen (COMT, CYP1B1, CYP1A1, ESR1), in relation to ..
  7. Nima Sharifi; Fiscal Year: 2016
    ..The survival benefit conferred by abiraterone acetate, which blocks CYP17A1, is the best evidence for the necessity of androgen synthesis in the progression of CRPC...
  8. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
    ..associated with plasma hormone levels, 2) characterize genetic variation of estrogen biosynthesis genes (CYP11A, CYP17, CYP19, HSD3B1, HSD3B2, HSD17B1, HSD17B2, and SHBG) using a two-pronged approach (putative functional variants and ..
  9. Angela M Brodie; Fiscal Year: 2014
    ..synthesized and identified a number of novel compounds that are potent inhibitors of 171-hydroxylase/C17,20-lyase (CYP17)...
  10. Emily E Scott; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Cytochrome P450 17A1 (CYP17A1) is a dual-function monooxygenase with a key role in human steroidogenesis...
  11. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..By affecting steroid production, genetic variants of 3 and 17betaHSD, CYP11A, CYP17, and CYP 19 may affect risk for ovarian cancer...
  12. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..We will evaluate the CYP11A1, CYP17, CYP19, 3Beta hydroxysteroid dehydrogenase, 17BETA hydroxysteroid dehydrogenase types 2,3, 5, and SRD5A2 genes...
  13. Pharmacogenomics of Human P450 Oxidoreductase
    Walter L Miller; Fiscal Year: 2012
    ..In vitro assays show that A503V has decreased activities in assays based on cytochrome c and P450c17, but not in assays based on CYP1A2 and CYP2C19...
  14. Regulation of Steroidogenic Genes by Trophic Hormones
    Marion B Sewer; Fiscal Year: 2013
    ..distinct signaling cascades promotes the PTM of multiple proteins that regulate the transcription and splicing of CYP17. Further, signal-dependent PTMs of SF-1 and NONO, modulate the differential assembly of protein complexes that ..
  15. Mechanism of Metformin Action in Normal and PCOS Theca Cells
    Jan M McAllister; Fiscal Year: 2012
    ..will examine the role(s) of LKB1, AMPK, and the salt inducible kinases, SIK1 and SIK2, in metformin inhibition of CYP17 and CYP11A1 gene expression and androgen biosynthesis in normal and PCOS theca cells propagated in long-term ..
  16. HORMONAL REGULATION OF STEROIDOGENESIS
    Synthia Mellon; Fiscal Year: 1990
    ..probes for the cholesterol side chain cleavage enzyme (P450scc), 21-hydroxylase (P450c21), and 17-hydroxylase (P450c17), we propose to use in situ hybridization histochemistry to determine the precise cell types responsible for the ..
  17. MOLECULAR REGULATION OF STEROIDOGENESIS
    WALTER MILLER; Fiscal Year: 1999
    ..The second enzyme is P450c17, which serves as a key branch point in the production of the different classes of steroid hormones...
  18. Molecular basis of androgen receptor mediated gene transcriptional repression
    Changmeng Cai; Fiscal Year: 2013
    ..led to two major findings: (1) increased intratumoal androgen synthesis that mediates tumor resistance to ADT and CYP17A1 inhibition;(2) increased AR expression in CRPC is due to AR suppression of its own gene...
  19. Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus
    Charles A Ducsay; Fiscal Year: 2013
    ..of the LTH fetus also adapts in response to LTH including a reduced expression of key steroidogenic enzymes (CYP17 and CYP11A1). Cumulatively, these seemingly contradictory adaptations in the hypothalamo-pituitary vs...
  20. Regulation of P450c17 Lyase Activity in Adrenache
    Qing Dong; Fiscal Year: 2007
    ..The conversion of 17OH pregnenolone to DHEA by the 17,20 lyase activity of cytochrome P450c17 determines the amount of C-19 steroid produced in both tissues...
  21. ACTH INDUCTION OF CYTOCHROME P450 IN ADRENAL CELLS
    Michael Waterman; Fiscal Year: 2002
    ..determine how four homeodomain proteins binding to the predominant cAMP response sequence (CRS1) of bovine CYP17 (P450c17) interact with one another and the basal transcription machinery...
  22. EPIDEMIOLOGY OF MENOPAUSE AND DEMENTIA IN DOWN SYNDROME
    Nicole Schupf; Fiscal Year: 2009
    ..We will examine 5 candidate genes: ERalpha, ERbeta, CYP17, CYP19, and HSD17B1...
  23. Reproductive and Hormonal Risk Factors for Adenomyosis
    Victoria Holt; Fiscal Year: 2006
    ..Blood samples will be analyzed for two polymorphic genes coding enzymes active in estrogen metabolism (CYP17, COMT)...
  24. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..whether dietary fat intake affects pregnancy estrogen levels in women, perhaps by interacting with polymorphism in CYP17 and COMT, and (2) to study whether highest pregnancy estrogen levels might increase breast cancer risk by ..
  25. THE MOLECULAR BASIS OF ADRENARCHE: DISSECTION OF P450C17
    Richard Auchus; Fiscal Year: 2000
    This proposal is to supplement grant K08DK02387, The molecular basis of adrenarche: dissection of P450c17 activities...
  26. HEPATIC MICROSOMAL DRUG OXIDATION
    Ronald Estabrook; Fiscal Year: 2000
    ..Lastly, it is planned to compare the enzymatic properties of orthologous forms of P450c17 that are known to have species-specific activities...
  27. Estrogen Metabolism Related Genes & Endometrial Cancer
    Anne Zeleniuch Jacquotte; Fiscal Year: 2007
    ..2) Functional polymorphisms in selected genes coding for enzymes involved in estrogen synthesis or metabolism (CYP17, CYP1B 1, COMT) are associated with risk of endometrial cancer; and (3) Selected polymorphisms in the progesterone ..
  28. Estrogen and Progesterone-related Gene Variants and Colorectal Cancer Risk
    Shumin Zhang; Fiscal Year: 2009
    ..and the conversion of progesterone to estrogens via androgens (HSD17B1, HSD17B2, HSD17B4, CYP19A1, and CYP17A1) and for estrogen catabolism (CYP1A1, CYP1B1, and COMT)...
  29. MOLECULAR BASIS OF ADRENARCHE--DISSECTION OF P450C17
    Richard Auchus; Fiscal Year: 2000
    We propose to thoroughly define the structural components of human P450c17 (17alpha-hydroxylase/17,20 lyase) that contribute to its two activities and to identify the physiologic factors that regulate the ratio of these two activities...
  30. GENES AND THE ESTROGEN EFFECT ON ENDOMETRIAL CANCER
    Giske Ursin; Fiscal Year: 2006
    ..We propose to evaluate a series of eight candidate genes (CYP17, CYP19, HSD17B1, ER, CYP1A1, CYP1B1, COMT andPR) in the estrogen biosynthesis, transactivation and metabolism ..
  31. Phytoestrogens and breast cancer risk
    Susan McCann; Fiscal Year: 2006
    ..the effect of dietary lignan supplementation on serum estrogen and phytoestrogen levels, and the impact of CYP17 and COMT polymorphisms on this relationship...
  32. BREAST CANCER AND GENE POLYMORPHISMS IN CHINESE WOMEN
    Chu Chen; Fiscal Year: 2003
    ..most known polymorphisms of a number of genes involved in the biosynthesis and catabolism of estrogens (CYP11a, CYP17, EDH17beta2, CYP1A1, CYP1A2, CYP1B1, COMT), and those for the androgen receptor, estrogen receptor and IGF-I genes ..
  33. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..2) To determine if genotype at the metabolic enzyme loci CYP1A1, CYP1B1, CYP17, CYP19, GSTM1, GSTP1, COMT, and NQO1 are associated with risk of adenocarcinoma of the lung in women...
  34. Plasma Diagnostic for Alzheimer's Disease Pathology
    Vassilios Papadopoulos; Fiscal Year: 2004
    ..of neuronal functions, including DHEA, (2) DHEA biosynthesis is mediated by a cytochrome P450 17 (-hydroxylase (P450c17)-independent mechanism involving a yet unidentified hydroperoxide precursor, (3) This pathway is regulated by ..
  35. PROSTATE CANCER IN MEXICANS AMERICANS & AFRICAN AMERICAN
    Sara Strom; Fiscal Year: 2003
    ..markers of genetic susceptibility and hormonal modulation, such as androgen receptor, 5-alpha-reductase type II, CYP17, CYP1B1, 3-beta-hydroxsteroid type II and vitamin D receptor, will be analyzed to determine if genotypic ..
  36. Developmental Differences in Brain Androgen Synthesis
    Sarah London; Fiscal Year: 2004
    ..This will be investigated using in situ hybridization. It is hypothesized that the different levels of CYP17 mRNA reflect sex differences in protein-mediated transcriptional regulation...
  37. BRCA1 AND BRCA2 IN AFRICAN-AMERICAN AND LATINO FAMILIES
    Brian Henderson; Fiscal Year: 2002
    ..Specifically, this application will investigate the role of BRCA1, BRCA2, the cytochrome P450cl7alpha gene (CYP17), and the 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) among African-American and Latino families with a ..
  38. Hormonal Factors in Invasive and LMP Ovarian Cancers
    Wendy Brewster; Fiscal Year: 2006
    ..hormone metabolism (metabolic genetic factors; estrogen metabolism genes, specifically cytochrome P450c17alpha (CYP17) gene, the aromatase (CYP19) gene and COMT) act together, and also interact with well-known hormonally related ..
  39. Paracrine role of MIS in Steroidogenesis
    CHRISTOPHER HOUK; Fiscal Year: 2003
    ..the mechanism's of the lyase suppression I plan to investigate MIS's effect using a viral-promoter driven P450c17 gene, and I also plan to examine MIS's effect on the phosphorylation state of the P450c17 enzyme, a potential ..
  40. GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTS
    Brian Henderson; Fiscal Year: 2000
    ..this proposal will investigate polymorphisms in candidate genes (NAT2, GSTM1, CYP1A1, SRD5A2, AR, EDH17B2, CYP17, and ER), that might alter metabolism of relevant endogenous or exogenous exposures and their interactions with ..
  41. TUMOR NECROSIS FACTOR REPRESSION OF STEROIDOGENIC GENES
    DALE HALES; Fiscal Year: 1999
    ..testosterone production: specifically, the TNF-mediated inhibition of the key testosterone biosynthetic enzyme, P450c17 (cyp17)...
  42. ANDROGEN PRODUCTION IN ADRENARCHE AND PCOS
    WALTER MILLER; Fiscal Year: 2006
    ..The conversion of 17OH pregnenolone to DHEA by the 17,20 lyase activity of cytochrome p450c17 determines the amount of androgen produced in both tissues...
  43. Gene Interactions, Estrogen, and Risk of Breast Cancer
    Kathleen Egan; Fiscal Year: 2006
    ..Genes included in this proposal are involved at key branch points in estrogen synthesis (STAR, CYP11A1, HSD 3B, CYP17, CYP19, HSD17B , TNF, IL6, PPAR G, STS), in steroid signaling (ESR1, ESR2, PGR, SHBG, AIB1), and in estrogen ..
  44. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..will investigate polymorphisms in genes coding for enzymes that:1) metabolize nutrients and hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, ..
  45. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..This membrane anchor is important for activity but complicates biochemical and biophysical studies. P450c17 (17- hydroxylase/17, 20-1yase) occupies a critical position in steroidogenesis, regulating the flux of precursors ..
  46. Neurosteroids and Smith-Lemli-Optiz Syndrome
    Cedric Shackleton; Fiscal Year: 2005
    ..All studies will require high sensitivity steroid analysis by chemical ionization (CI) GC/MS and HPLC/MS. ..
  47. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..Some of the genes that are important in estrogen metabolism have been found to be polymorphic (CYP17, CYP1 Al, catechol 0-methyltransferase, CYP1 Bi, and CYP19), raising the question of whether genotypes are related ..
  48. REDUCTASE INTERACTIONS GOVERNING AROMATASE ACTIVITIES
    Alan Conley; Fiscal Year: 2001
    ..3) To investigate competition between P450arom and P450c17 affecting ovarian androgen and estrogen synthesis...
  49. MECHANISMS OF PREGNANCY INDUCED AT 1 RECEPTOR EXPRESSION
    Ian Bird; Fiscal Year: 2001
    ..Aim 3 is to determine in vitro whether changes in expression result from changes in phospholipase C and PGI2 production. ..
  50. New Paradigms of P450-mediated Steroids Metabolism
    Alan Conley; Fiscal Year: 2006
    ..health of women, but therapies targeting the enzyme responsible, 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17), have been difficult to develop due to an incomplete understanding of the regulation of the 17,20-lyase activity ..
  51. SMITH-LEMLI-OPITZ SYNDROME STEROIDOGENESIS
    Cedric Shackleton; Fiscal Year: 2002
    ..Finally, if ring B dehydrosteroids are produced, is the ratio of the individual dehydrometabolites to corresponding conventional metabolites related to the dehydrocholesterol to cholesterol ratio and clinical severity? ..
  52. Gas chromatograph-mass spectrometer with EI and CI
    Cedric Shackleton; Fiscal Year: 2003
    ..g., malondialdehyde) and markers of DNA damage (incorporation of uracil). Dr Kuypers has several projects on the red cell membrane, which require profiling of fatty acids using EI GC/MS. ..
  53. PREGNANCY CHANGES IN UTERINE ARTERY SIGNALING PATHWAYS
    Ian Bird; Fiscal Year: 2004
    ..abstract_text> ..
  54. 17 alpha-Hydroxylase Expression in Human Ovarian Cells
    Jan M McAllister; Fiscal Year: 2010
    ..we obtained exciting data demonstrating that increased androgen production and augmented P450 17a-hydroxylase (CYP17) gene expression in PCOS theca cells results from a combined reduction in the activation state of the MEK1/ERK ..
  55. Post-translational regulation of CYP17 activity
    Denis Magoffin; Fiscal Year: 2008
    ..The key enzyme required for androgen biosynthesis is known as CYP17. The enzyme has two activities, one of which, the C17-20 lyase activity, is increased by phosphorylation...
  56. GENETIC EPIDEMIOLOGY OF PROSTATE CANCER
    Janet Stanford; Fiscal Year: 2008
    ..abstract_text> ..
  57. REGULATION OF REPRODUCTION
    Synthia Mellon; Fiscal Year: 2005
    ..We will focus on the gene encoding P450c17 (17alpha hydroxylase/17,2 lyase) as it is the key branch point in steroidogenesis, it has been implicated in the ..
  58. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
  59. GENETIC POLYMORPHISMS IN THE GSTPI LOCUS AND PROSTATE CA
    Janet Stanford; Fiscal Year: 2001
    ....
  60. A Pooled Analysis to Identify New Ovarian Cancer Risk Factors
    Celeste Leigh Pearce; Fiscal Year: 2010
    ..Gaining a better understanding of ovarian cancer, which this project will provide, is critical to identifying women at risk and for improving the outcome for women who are diagnosed with this disease. ..
  61. Ovarian Cancer and Gonadotropin Signaling
    CELESTE PEARCE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  62. Naturopathic Treatments: Effects on Estrogen Metabolism
    Heather Greenlee; Fiscal Year: 2003
    ..Data will be collected and analyzed on changes in estrogen rations and hormone profiles. ..
  63. GENETIC POLYMORPHISMS AND PROSTATE CANCER RISK
    Janet Stanford; Fiscal Year: 2001
    ..abstract_text> ..
  64. A Genome-Wide Association Study of Non-Hodgkin Lymphoma
    Christine F Skibola; Fiscal Year: 2010
    ..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
  65. DIETARY AND GENETIC DETERMINANTS OF MAMMOGRAPHIC DENSITY
    Anna Wu; Fiscal Year: 2008
    ..abstract_text> ..
  66. Inflammatory Pathway Gene Polymorphisms and Risk of Prostate Cancer
    Janet Stanford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  67. AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY
    John Hopper; Fiscal Year: 2007
    ..i ..
  68. The Role of Hormone Polymorphisms in Menstrual Function and Fertility
    CHANLEY SMALL; Fiscal Year: 2008
    ..In addition, we will examine three common variants of CYP17 and CYP19, central genes in estrogen biosynthesis...
  69. A genomic scan of hereditary prostate cancer families with an occurrence of colon
    Janet Stanford; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..