Genomes and Genes
Gene Symbol: cyclin E
Description: cyclin E1
Alias: CCNE, pCCNE1, G1/S-specific cyclin-E1
Publications209 found, 100 shown here
- ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell lineRana Varshochi
Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
J Biol Chem 280:3185-96. 2005....
- Inhibition of HIV-1 virus replication using small soluble Tat peptidesEmmanuel Agbottah
Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington DC 20037, USA
Virology 345:373-89. 2006..The peptides are not toxic to cells and target the Cdk2/Cyclin E complex, inhibiting the phosphorylation of serine 5 of RNAPII...
- Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progressionAnne Sophie Borowiec
Laboratoire de Physiologie Cellulaire, JE2530, Universite de Picardie Jules Verne, 33 rue St Leu, Amiens, 80039, France
Biochim Biophys Acta 1813:723-30. 2011..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
- Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesisTanushri Sengupta
Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Mol Cell Biol 31:3885-95. 2011Increased cyclin E expression has been identified in human tumors of diverse histologies, and in studies of primary breast cancers, high cyclin E is associated with poor prognosis...
- BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphomaSylvia Hoeller
Department of Pathology, University of Basel, Basel, Switzerland
Histopathology 56:217-28. 2010....
- HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoterLongwen Deng
Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, D C 20037, USA
J Biol Chem 277:33922-9. 2002..Recombinant CDK2/cyclin E stimulated Tat-dependent HIV-1 transcription in reconstituted transcription assay...
- Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and RevSergei Nekhai
Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biolology, Howard University, NW Washington, DC 20059, USA
Future Microbiol 1:417-26. 2006..Tat interacts with protein kinase complexes Cdk9/cyclin T1 and Cdk2/cyclin E; acetyltransferases p300/CBP, p300/CBP-associated factor and hGCN5; protein phosphatases and other factors...
- Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrestSandra Ciarallo
Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
Mol Cell Biol 22:2993-3002. 2002..Altered phosphorylation of p27 in the resistant 184A1L5(R) cells may favor the binding of p27 to cyclin D1-cdk4 and prevent its accumulation in cyclin E1-cdk2 in response to TGF-beta...
- Effect of transcription peptide inhibitors on HIV-1 replicationRachel Van Duyne
The George Washington University Medical Center, Department of Microbiology, Immunology, and Tropical Medicine, Washington, DC 20037, USA
Virology 376:308-22. 2008..This binding event is mediated by the phosphorylation of Pol II by complexes such as cdk9/Cyclin T and cdk2/Cyclin E. Recent studies have shown that a Tat 41/44 peptide derivative prevents the loading of cdk2 onto the HIV-1 ..
- Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1N Dyson
Massachusetts General Hospital Cancer Center, Charlestown 02129
J Virol 67:7641-7. 1993..p107-associated proteins included cyclin A, cyclin E, and cdk2...
- Tat protein induces self-perpetuating permissivity for productive HIV-1 infectionC J Li
Division of Cell Growth and Regulation, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA cjli mbcrr harvard edu
Proc Natl Acad Sci U S A 94:8116-20. 1997..Accordingly, these primary T cells progressed from G0 to the late G1 phase of the cell cycle...
- HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial originM Kundu
Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
J Biol Chem 273:8130-6. 1998..Consistent with this observation, lower levels of cyclin E-Cdk2 kinase activity and phosphorylated Rb were detected in the Tat-treated cells compared with the control cells...
- Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinasesI Blomberg
Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
Mol Cell Biol 19:6183-94. 1999..We further demonstrate that Cdc25A is activated at the same time as cyclin E- and cyclin A-dependent kinases...
- NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entryA Boudrez
Afdeling Biochemie and Center for Human Genetics VIB, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium
J Biol Chem 275:25411-7. 2000..The binding of the FHA domain of NIPP1 to CDC5L was dependent on the phosphorylation of CDC5L, e.g. by cyclin E-Cdk2...
- Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsP W Hinds
Whitehead Institute, Cambridge, Massachusetts 02142
Cell 70:993-1006. 1992..in cells overexpressing these cyclins, and this phosphorylation is essential for cyclin A- and cyclin E-mediated rescue of pRb-blocked cells...
- Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycleA Koff
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
Science 257:1689-94. 1992Human cyclin E, originally identified on the basis of its ability to function as a G1 cyclin in budding yeast, associated with a cell cycle-regulated protein kinase in human cells...
- Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeastD J Lew
Department of Molecular Biology, MB7 Scripps Research Institute, La Jolla, California 92037
Cell 66:1197-206. 1991..Cyclin C and E mRNAs accumulate periodically through the cell cycle, peaking at different times in G1...
- Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene familyA Koff
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Cell 66:1217-28. 1991A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae...
- Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)D J Demetrick
Howard Hughes Medical Institute, Cold Spring Harbor, NY, USA
Cytogenet Cell Genet 69:190-2. 1995..mapping by FISH of the genes for several cdk-associated proteins including human CCNC (cyclin C) to 6q21, CCNE (cyclin E) to 19q12-->q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22)...
- Human cyclin E, a nuclear protein essential for the G1-to-S phase transitionM Ohtsubo
Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Mol Cell Biol 15:2612-24. 1995b>Cyclin E was first identified by screening human cDNA libraries for genes that would complement G1 cyclin mutations in Saccharomyces cerevisiae and has subsequently been found to have specific biochemical and physiological properties that ..
- Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylationB E Clurman
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
Genes Dev 10:1979-90. 1996b>Cyclin E is a mammalian G1 cyclin that is both required and rate limiting for entry into S phase. The expression of cyclin E is periodic, peaking at the G1-S transition and then decaying as S phase progresses...
- Cyclin E-CDK2 is a regulator of p27Kip1R J Sheaff
Division of Basic Sciences, Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington 98104, USA
Genes Dev 11:1464-78. 1997..We show that expression of cyclin E-CDK2 in murine fibroblasts causes phosphorylation of the CDK inhibitor p27Kip1 on T187, and that cyclin E-CDK2 ..
- Cyclin E-induced S phase without activation of the pRb/E2F pathwayJ Lukas
Danish Cancer Society, Division of Cancer Biology, Copenhagen
Genes Dev 11:1479-92. 1997In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2F ..
- Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27J Vlach
Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
EMBO J 16:5334-44. 1997..Through its intact cyclin contact, p27(k-) associated with active cyclin E-CDK2 and, unlike wild type p27, p27(c-) or p27(ck-), was efficiently phosphorylated by CDK2 on a conserved C-..
- Deregulated cyclin E induces chromosome instabilityC H Spruck
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Nature 401:297-300. 1999b>Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (Cdk2), is an important regulator of entry into S phase in the mammalian cell cycle...
- Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1J W Harbour
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cell 98:859-69. 1999..Cdk4/6 is activated early in G1, blocking active repression by Rb. However, it is not until near the end of G1, when cyclin E is expressed and Cdk2 is activated, that Rb is prevented from binding and inactivating E2F.
- Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsJ D Singer
Division of Basic Sciences, Howard Hughes Medical Institute, Seattle, Washington 98109 USA
Genes Dev 13:2375-87. 1999b>Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380...
- Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplicationK Nakayama
Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
EMBO J 19:2069-81. 2000..Skp2(-/-) cells also exhibit increased accumulation of both cyclin E and p27(Kip1)...
- Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cellsS Mazumder
Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, OH 44195, USA
Oncogene 19:2828-35. 2000b>Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2 (Cdk2)...
- Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseD M Koepp
Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA
Science 294:173-7. 2001b>Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of the cell cycle...
- Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell linesK H Moberg
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Nature 413:311-6. 2001..embryogenesis, exit from the cell cycle is contingent on tightly controlled downregulation of the activity of Cyclin E-Cdk2 complexes that normally promote the transition from G1 to S phase...
- Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell lineH Strohmaier
Department of Molecular Biology, MB 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 413:316-22. 2001b>Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1-S phase transition and is thought to be critical for the initiation of DNA replication and other S-phase functions...
- The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb nodeMartin Lodén
Department of Pathology, Umea University, S 901 87 Umea, Sweden
Oncogene 21:4680-90. 2002..cyclin D1 and elevated retinoblastoma protein (pRb) phosphorylation, (cyclin D1(high) tumours) or (2) with high cyclin E protein but low cyclin D1 and lack of corresponding pRb phosphorylation (cyclin E(high) tumours) indicative of an ..
- Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligaseStephen Orlicky
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
Cell 112:243-56. 2003..A 2.7 A X-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4...
- Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradationMarkus Welcker
Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 12:381-92. 2003Autophosphorylation-triggered ubiquitination has been proposed to be the major pathway regulating cyclin E protein abundance: phosphorylation of cyclin E on T380 by its associated CDK allows binding to the receptor subunit, Fbw7, of the ..
- The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signalingAbdolrahman S Nateri
Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Science 303:1374-8. 2004..SCF(Fbw7) therefore antagonizes the apoptotic c-Jun-dependent effector arm of JNK signaling, allowing neurons to tolerate potentially neurotoxic JNK activity...
- A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyS Mazumder
Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation NB40, Cleveland, OH 44195, USA
Curr Cancer Drug Targets 4:65-75. 2004b>Cyclin E is essential for progression through the G1-phase of the cell cycle and initiation of DNA replication by interacting with and activating its catalytic partner, the cyclin dependent kinase 2 (Cdk2)...
- Inactivation of hCDC4 can cause chromosomal instabilityHarith Rajagopalan
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Nature 428:77-81. 2004..traced to a defect in the execution of metaphase and subsequent transmission of chromosomes, and is dependent on cyclin E--a protein that is regulated by hCDC4 (refs 2-4)...
- Cyclin E deregulation alters the biologic properties of ovarian cancer cellsIsabelle Bedrosian
Department of Surgical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
Oncogene 23:2648-57. 2004We have previously shown that the low molecular weight (LMW) forms (trunk 1 and trunk 2) of cyclin E are biochemically hyperactive and induce G1/S progression in normal epithelial cells...
- Deregulation of cyclin E in human cells interferes with prereplication complex assemblySusanna Ekholm-Reed
Dept of Molecular Biology, MB 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
J Cell Biol 165:789-800. 2004Deregulation of cyclin E expression has been associated with a broad spectrum of human malignancies...
- Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligaseXin Ye
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 279:50110-9. 2004Turnover of cyclin E is controlled by SCF(Fbw7). Three isoforms of Fbw7 are produced by alternative splicing...
- A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entryYutaka Matsumoto
Howard Hughes Medical Institute HHMI and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA
Science 306:885-8. 2004Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells...
- The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27Hannah Wingate
Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
J Biol Chem 280:15148-57. 2005The low molecular weight (LMW) isoforms of cyclin E are unique to cancer cells. In breast cancer, such alteration of cyclin E is a very strong predictor of poor patient outcome...
- Ras activity regulates cyclin E degradation by the Fbw7 pathwayAlex C Minella
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Proc Natl Acad Sci U S A 102:9649-54. 2005The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis...
- Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patientsAnieta M Sieuwerts
Department of Medical Oncology, Erasmus MC, Rotterdam, The Netherlands
Clin Cancer Res 12:3319-28. 2006To evaluate the prognostic value of cyclin E with a quantitative method for lymph node-negative primary breast cancer patients.
- Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferationP Potemski
Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
J Exp Clin Cancer Res 25:59-64. 2006The main objective of this retrospective study was to investigate relations between cyclin E and pathoclinical factors in patients with operable breast cancer...
- Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoformsFrank van Drogen
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Cell 23:37-48. 2006b>Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4)...
- Kinase-independent function of cyclin EYan Geng
Department of Cancer Biology, Dana Farber Cancer Institute, USA
Mol Cell 25:127-39. 2007..We previously found that cyclin E-null cells failed to incorporate MCM helicase into DNA prereplication complex during G(0) --> S phase ..
- Fbw7/hCDC4 dimerization regulates its substrate interactionsMarkus Welcker
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, USA
Cell Div 2:7. 2007The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize...
- Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomasYan Ma
Department of Pharmacology and Toxicology, and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 104:4089-94. 2007b>Cyclin E is a critical G(1)-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored...
- Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesBing Hao
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cell 26:131-43. 2007The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer...
- The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemiaBenjamin J Thompson
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 204:1825-35. 2007..abrogate the binding of FBW7 not only to NOTCH1 but also to the two other characterized targets, c-Myc and cyclin E. The majority of the FBW7 mutations were present during relapse, and they were associated with NOTCH1 HD ..
- Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)Jamie M Keck
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037
J Cell Biol 178:371-85. 2007Overexpression of cyclin E, an activator of cyclin-dependent kinase 2, has been linked to human cancer...
- Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohortElizabeth M Azzato
Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
Breast Cancer Res 10:R47. 2008..Of particular interest are genes involved in cell cycle pathways, which regulate cell division...
- cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosisHege Ugland
Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
Mol Biol Cell 19:5082-92. 2008..Concomitantly, however, the level of cyclin E markedly increases upon cAMP induction, indicating that cyclin E may have cdk2-independent functions in these ..
- Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationAnjanabha Saha
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Mol Cell 32:21-31. 2008....
- Cyclin E deregulation is an early event in the development of breast cancerAlexandra Shaye
Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
Breast Cancer Res Treat 115:651-9. 2009b>Cyclin E has been shown to be overexpressed in some human breast cancers, however, data to support deregulation of cyclin E as an early event in human mammary tumor development is lacking...
- Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer riskEllen L Goode
Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 18:935-44. 2009..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
- Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancerRoshan Agarwal
The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
Clin Cancer Res 15:3654-62. 2009..We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling...
- Post-translational modification and stability of low molecular weight cyclin EB B Mull
Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 28:3167-76. 2009Our laboratory has previously described the presence of five tumor-specific low molecular weight isoforms of cyclin E in both tumor cell lines and breast cancer patient biopsies...
- A study of the expression of Cyclin E and its isoforms in tumor and adjacent mucosa, correlated to patient outcome in early colon cancerIrina Corin
Department of Surgery, Sahlgrenska University Hospital Ostra, 41685 Gothenburg, Sweden
Acta Oncol 49:63-9. 2010b>Cyclin E, a key regulator in the cell cycle, is often over-expressed in malignant disease. It can present as full length (FL) and low-molecular-weight (LMW) isoforms...
- Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancerNaomi Nakayama
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
Cancer 116:2621-34. 2010..This study examined the clinical significance of CCNE1 (Cyclin E1) amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian cancer...
- A novel interaction between HER2/neu and cyclin E in breast cancerE A Mittendorf
Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 29:3896-907. 2010HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. As both are involved in cell cycle regulation we analyzed whether there was a direct interaction between the two...
- A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
- Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylationNimesh Bhaskaran
Department of Cell and Molecular Biology, The Karolinska Institute, Stockholm, Sweden
Mol Cell Biol 33:85-97. 2013..The ubiquitin ligase that targets phosphorylated cyclin E is SCF(Fbw7) (also known as SCF(Cdc4)), a member of the cullin ring ligase (CRL) family...
- Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasmMark Jackman
Wellcome Cancer Research U K London Institute and Department of Zoology, University of Cambridge, Cambridge, United Kingdom CB2 1QR
Mol Biol Cell 13:1030-45. 2002..However, recently, both cyclin A and cyclin E have been implicated as regulators of centrosome replication, and it is unclear when and where these cyclin-Cdks ..
- Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancerSimon A Gayther
Translational Research Laboratories, University College London, London, United Kingdom
Cancer Res 67:3027-35. 2007..This study highlights the need for multicenter collaborations for genetic association studies...
- Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British populationKristy E Driver
Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK
Carcinogenesis 29:333-41. 2008..010, P-trend = 0.048). Further large-scale studies are needed to confirm these results...
- Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survivalHonglin Song
CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
Clin Cancer Res 14:1090-5. 2008..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types...
- Stabilization of N-Myc is a critical function of Aurora A in human neuroblastomaTobias Otto
Institute of Molecular Biology and Tumor Research, Marburg, Germany
Cancer Cell 15:67-78. 2009..Aurora A interacts with both N-Myc and the SCF(Fbxw7) ubiquitin ligase that ubiquitinates N-Myc and counteracts degradation of N-Myc, thereby uncoupling N-Myc stability from growth factor-dependent signals...
- Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin EK A Won
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
EMBO J 15:4182-93. 1996A yeast screen was developed to identify mutations in human cyclin E that lead to stabilization of the protein in order to identify determinants important for cyclin E turnover...
- Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer casesY Takano
Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
Am J Pathol 156:585-94. 2000..We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse ..
- Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinomaRaul Cassia
Laboratory of Breast and Gynaecological Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
J Pathol 201:589-95. 2003b>Cyclin E overexpression occurs in a subset of endometrial carcinomas (ECs), but the molecular mechanisms underlying this alteration remain to be established...
- Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin EM J Dealy
Department of Biology, University of California, San Diego, California 92093 0366, USA
Nat Genet 23:245-8. 1999..We show that Cul1 is required for early mouse development and that Cul1 mutants fail to regulate the abundance of the G1 cyclin, cyclin E (encoded by Ccne), during embryogenesis.
- Identification of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, Oncorhynchus kisutchJohn A Luckenbach
School of Aquatic and Fishery Sciences, University of Washington, Seattle, Washington 98195, USA
Reprod Biol Endocrinol 6:2. 2008..The aim of this study was to identify differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, a semelparous teleost that exhibits synchronous follicle development...
- Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclinYulia A Nevzorova
Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
Gastroenterology 137:691-703, 703.e1-6. 2009..We investigated the relevance of E-cyclins in directing resting hepatocytes into the cell cycle after partial hepatectomy using CcnE1 and CcnE2 knockout mice...
- Sporadic invasive breast carcinomas with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification studySocorro Maria Rodriguez-Pinilla
Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Am J Surg Pathol 31:501-8. 2007..In addition, we analyzed EGFR, C-MYC, and CCNE gene amplification by fluorescence in situ hybridization, because the expression of these genes is known to be ..
- Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: a case control studyDemetrios A Arvanitis
Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
Oncol Rep 20:751-60. 2008..The ability of this array of markers to identify disease status suggests that it could be used for diagnostic purposes...
- Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: a multiplex ligation-dependent probe amplification studyCathy B Moelans
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
Anal Cell Pathol (Amst) 33:165-73. 2010..These high-grade DCIS specific genes may be potential targets for treatment and/or predict progression...
- Effect of prostaglandin on luteinizing hormone-stimulated proliferation of theca externa cells from chicken prehierarchical folliclesYudong Jia
Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, China
Prostaglandins Other Lipid Mediat 92:77-84. 2010..These results suggest that PG may promote development of chicken prehierarchical follicles and is related to dominant follicle selection in laying hens...
- Potentially functional polymorphisms in cell cycle genes and the survival of non-small cell lung cancer in a Chinese populationHongxia Ma
Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, China
Lung Cancer 73:32-7. 2011..Further large and functional studies are needed to confirm our findings...
- Community-based nursing education and nursing accreditation by the Commission on Collegiate Nursing EducationS Van Ort
College of Nursing, University of Arizona, Tucson, AZ, USA
J Prof Nurs 16:330-5. 2000..is to describe the application of accreditation standards of the Commission on Collegiate Nursing Education (CCNE) in community-based nursing education...
- Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenesCathy B Moelans
Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
Mod Pathol 23:1029-39. 2010....
- Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemiaAndrea Caporali
Regenerative Medicine, School of Clinical Medicine, University of Bristol, Bristol, England, UK
Circulation 123:282-91. 2011..microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region...
- Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cellsLucie Tosca
Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
Biol Reprod 75:342-51. 2006..Metformin treatment (10 mM, 24 h) also reduced cell proliferation and the levels of CCND2 and CCNE proteins without affecting cell viability, both in the basal state and in response to FSH...
- Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expressionJames Adjaye
Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Physiol Genomics 31:315-27. 2007....
- Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cellsY Choi
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151 742, Korea
Br J Pharmacol 157:1053-64. 2009....
- Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cellsTiziana Parisi
DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
EMBO J 22:4794-803. 2003In mammalian cells, cyclin E-CDK2 complexes are activated in the late G1 phase of the cell cycle and are believed to have an essential role in promoting S-phase entry...
- Gene networks involved in apoptosis induced by hyperthermia in human lymphoma U937 cellsYukihiro Furusawa
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
Cell Biol Int 33:1253-62. 2009..These findings will provide a basis for understanding the detailed molecular mechanisms of apoptosis induced by hyperthermia at 42 degrees C in cells...
- Down-regulation of the cyclin E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cellsFu Wang
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, P R China
BMB Rep 42:725-30. 2009..Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy...
- Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancerDariush Etemadmoghadam
Cancer Genomics Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
PLoS ONE 5:e15498. 2010..Co-amplification at 19q12 and 20q11 implies the presence of a cooperative mutational network. These observations have implications for the application of targeted therapies in CCNE1 dependent ovarian cancers...
- MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domainMasuko Katoh
M and M Medical BioInformatics, Narashino 275 0022, Japan
Int J Oncol 22:1369-74. 2003..This is the first report on comprehensive characterization of the amplicon around the PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12...
- The FBXW7 beta-form is suppressed in human glioma cellsZhaodi Gu
Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
Biochem Biophys Res Commun 354:992-8. 2007..Our present results imply that FBXW7 plays a pivotal role in many tissues by controlling the amount of cell cycle promoter proteins and that dysfunction of this protein is one of the essential steps in carcinogenesis in multiple organs...
- Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition womenAndrea L Niklaus
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Hum Reprod 22:1778-88. 2007....
- Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: a potential role in G1/S escapeL B Jensen
Endocrine Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK
Cancer Biomark 5:41-9. 2009..Both markers were amplified in 14% and deleted in 5% of the cases. This is the first report of genomic deletions of MYC in breast cancer...
- Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization studyAndreas Gast
Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
Genes Chromosomes Cancer 49:733-45. 2010....
- Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"Klaus Golka
Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139, Dortmund, Germany
Arch Toxicol 85:539-54. 2011..In future, besides identifying novel disease-associated rare variants by deep sequencing, it will also be important to understand how the already identified variants interact...
- Rescue of cyclin D1 deficiency by knockin cyclin EY Geng
Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 97:767-77. 1999D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins...
- BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targetsEric S Calhoun
Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
Am J Pathol 163:1255-60. 2003..This study investigated the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary ..
- Identification of a three-gene expression signature of poor-prognosis breast carcinomaIvan Bieche
Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
Mol Cancer 3:37. 2004..The use of gene expression profiles could result in more accurate and objective prognostication...
- Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progressionShugaku Takeda
Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genes Dev 20:2397-409. 2006..Lastly, Taspase1(-/-) cells are resistant to oncogenic transformation, and Taspase1 is overexpressed in many cancer cell lines. Thus, Taspase1 may serve as a target for cancer therapeutics...
- Center of Cancer Nanotechnology Excellence Focused on Therapy ResponseSanjiv S Gambhir; Fiscal Year: 2010This Center for Cancer Nanotechnology Excellence focused on therapy response (CCNE-TR) brings together scientists and physicians from Stanford University, University of California Los Angeles (UCLA), Cedars Sinai Medical Center, Fredrick ..
- Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents forAndrew P Goodwin; Fiscal Year: 2011..He then continued to the Stanford University CCNE in the labs of Prof...
- Emory-GA Tech Nanotechnology Center for Personalized an*Shuming Nie; Fiscal Year: 2009This application proposes a cross-disciplinary Center of Cancer Nanotechnology Excellence (CCNE) at Emory University and Georgia Tech that will integrate nanotechnology with cancer biomolecular signatures (biomarkers) for personalized and ..
- Andrew P Goodwin; Fiscal Year: 2014..He then continued to the Stanford University CCNE in the labs of Prof...
- Lily Yang; Fiscal Year: 2014..Our extensive research supported by NCI CCNE program led to the development of biodegradable and receptor targeted magnetic iron oxide nanoparticles (lONP) as a ..
- Carolina Center of Cancer Nanotechnology ExcellenceRudolph Juliano; Fiscal Year: 2009DESCRIPTION (provided by the applicant): The Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) will bring together recent pioneering breakthroughs at UNC in nano-particle engineering with the world class excellence in the ..
- Sanjiv S Gambhir; Fiscal Year: 2014DESCRIPTION (provided by applicant): This Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) brings together scientists and physicians from Stanford University, University of California Berkeley/Lawrence Berkeley ..
- SANDY A NAPEL; Fiscal Year: 2016..Cellular and Molecular Imaging Center (ICMIC), the Center for Cancer Nanotechnology Excellence and Translation (CCNE-T), the Center for Advanced Magnetic Resonance Technology (CAMRT), and the Stanford Center for Cancer Systems ..
- Sanjiv S Gambhir; Fiscal Year: 2015..the Canary Foundation, and the National Cancer Institute, including a center for cancer nanotechnology excellence (CCNE) U54 and an in vivo cellular and molecular imaging center (ICMIC) P50...
- Nanomaterials for Cancer Diagnostics and TherapeuticsChad Mirkin; Fiscal Year: 2009..of a Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence (CCNE). To be led by the Principal Investigator, Chad A...
- MOLECULAR BASES OF CELL ADHESIONRudolph Juliano; Fiscal Year: 2003....
- Enhanced Delivery of Protein Biosensors: a Combinatorial Library StrategyRudolph Juliano; Fiscal Year: 2009..We anticipate that this approach will lead to a cohort of novel CPPs that will have an important impact on the entire field of intracellular delivery of proteins, especially biosensors. ..
- Cytotoxic lymphocytes in acute lung injuryMitzi Nagarkatti; Fiscal Year: 2008..unreadable] [unreadable]..
- Pathogenesis of HIVAN: the role of NefJOHN HE; Fiscal Year: 2007..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
- Role of CD44 in EC injury and melanoma therapyMitzi Nagarkatti; Fiscal Year: 2007..The proposed studies also form the basis for prventing EC injury in wide range of clinical manifestations. ..
- Major Challenges in Clinical Medicine: An Overview for *Rudolph Juliano; Fiscal Year: 2006..As part of this component the trainee, with the mentor's guidance, will prepare the Abstract and Specific Aims of an NIH-type grant proposal dealing with a translational research topic. ..
- TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDSRudolph Juliano; Fiscal Year: 2005..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
- Conference on Signaling Via Cell-Cell InteractionsRudolph Juliano; Fiscal Year: 2003..The proposed program will present a unique training opportunity for students and post-doctoral fellows, since it will provide a unifying thematic structure to converging, but still disparate, areas of research. ..
- The role of Cyclin E in growth control and tumorogenesisSteven Reed; Fiscal Year: 2008b>Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2) is a positive activator of the G1-S phase transition in proliferating mammalian cells and therefore serves an important function during development and in replenishment of tissues...
- Function and regulation of cyclin E-Cdk2 substrate NPATJiyong Zhao; Fiscal Year: 2007..To understand how cyclin E-Cdk2, a key CDK required for the G1-to-S phase transition, executes its function in vivo, we developed a strategy ..
- THE S. CEREVISIAE S PHASE CHECKPOINTSteven Reed; Fiscal Year: 2003....
- GENETIC LINKAGE IN COLORECTAL CANCER FAMILESEllen Goode; Fiscal Year: 2008..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..