cyclin E

Summary

Gene Symbol: cyclin E
Description: cyclin E1
Alias: CCNE, pCCNE1, G1/S-specific cyclin-E1
Species: human

Top Publications

  1. ncbi ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    Rana Varshochi
    Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 280:3185-96. 2005
  2. ncbi Inhibition of HIV-1 virus replication using small soluble Tat peptides
    Emmanuel Agbottah
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington DC 20037, USA
    Virology 345:373-89. 2006
  3. doi Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progression
    Anne Sophie Borowiec
    Laboratoire de Physiologie Cellulaire, JE2530, Universite de Picardie Jules Verne, 33 rue St Leu, Amiens, 80039, France
    Biochim Biophys Acta 1813:723-30. 2011
  4. pmc Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis
    Tanushri Sengupta
    Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Cell Biol 31:3885-95. 2011
  5. doi BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma
    Sylvia Hoeller
    Department of Pathology, University of Basel, Basel, Switzerland
    Histopathology 56:217-28. 2010
  6. ncbi HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter
    Longwen Deng
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, D C 20037, USA
    J Biol Chem 277:33922-9. 2002
  7. ncbi Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev
    Sergei Nekhai
    Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biolology, Howard University, NW Washington, DC 20059, USA
    Future Microbiol 1:417-26. 2006
  8. pmc Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest
    Sandra Ciarallo
    Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Mol Cell Biol 22:2993-3002. 2002
  9. doi Effect of transcription peptide inhibitors on HIV-1 replication
    Rachel Van Duyne
    The George Washington University Medical Center, Department of Microbiology, Immunology, and Tropical Medicine, Washington, DC 20037, USA
    Virology 376:308-22. 2008
  10. pmc Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
    N Dyson
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    J Virol 67:7641-7. 1993

Research Grants

  1. Center of Cancer Nanotechnology Excellence Focused on Therapy Response
    Sanjiv S Gambhir; Fiscal Year: 2010
  2. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
  3. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2009
  4. Andrew P Goodwin; Fiscal Year: 2014
  5. Lily Yang; Fiscal Year: 2014
  6. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2009
  7. Sanjiv S Gambhir; Fiscal Year: 2014
  8. SANDY A NAPEL; Fiscal Year: 2016
  9. Sanjiv S Gambhir; Fiscal Year: 2015
  10. Nanomaterials for Cancer Diagnostics and Therapeutics
    Chad Mirkin; Fiscal Year: 2009

Detail Information

Publications209 found, 100 shown here

  1. ncbi ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    Rana Varshochi
    Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 280:3185-96. 2005
    ....
  2. ncbi Inhibition of HIV-1 virus replication using small soluble Tat peptides
    Emmanuel Agbottah
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, Washington DC 20037, USA
    Virology 345:373-89. 2006
    ..The peptides are not toxic to cells and target the Cdk2/Cyclin E complex, inhibiting the phosphorylation of serine 5 of RNAPII...
  3. doi Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progression
    Anne Sophie Borowiec
    Laboratoire de Physiologie Cellulaire, JE2530, Universite de Picardie Jules Verne, 33 rue St Leu, Amiens, 80039, France
    Biochim Biophys Acta 1813:723-30. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  4. pmc Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis
    Tanushri Sengupta
    Department of Medicine, Division of Hematology Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Cell Biol 31:3885-95. 2011
    Increased cyclin E expression has been identified in human tumors of diverse histologies, and in studies of primary breast cancers, high cyclin E is associated with poor prognosis...
  5. doi BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma
    Sylvia Hoeller
    Department of Pathology, University of Basel, Basel, Switzerland
    Histopathology 56:217-28. 2010
    ....
  6. ncbi HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter
    Longwen Deng
    Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington, D C 20037, USA
    J Biol Chem 277:33922-9. 2002
    ..Recombinant CDK2/cyclin E stimulated Tat-dependent HIV-1 transcription in reconstituted transcription assay...
  7. ncbi Transcriptional and post-transcriptional regulation of HIV-1 gene expression: role of cellular factors for Tat and Rev
    Sergei Nekhai
    Center for Sickle Cell Disease and Department of Biochemistry and Molecular Biolology, Howard University, NW Washington, DC 20059, USA
    Future Microbiol 1:417-26. 2006
    ..Tat interacts with protein kinase complexes Cdk9/cyclin T1 and Cdk2/cyclin E; acetyltransferases p300/CBP, p300/CBP-associated factor and hGCN5; protein phosphatases and other factors...
  8. pmc Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest
    Sandra Ciarallo
    Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Mol Cell Biol 22:2993-3002. 2002
    ..Altered phosphorylation of p27 in the resistant 184A1L5(R) cells may favor the binding of p27 to cyclin D1-cdk4 and prevent its accumulation in cyclin E1-cdk2 in response to TGF-beta...
  9. doi Effect of transcription peptide inhibitors on HIV-1 replication
    Rachel Van Duyne
    The George Washington University Medical Center, Department of Microbiology, Immunology, and Tropical Medicine, Washington, DC 20037, USA
    Virology 376:308-22. 2008
    ..This binding event is mediated by the phosphorylation of Pol II by complexes such as cdk9/Cyclin T and cdk2/Cyclin E. Recent studies have shown that a Tat 41/44 peptide derivative prevents the loading of cdk2 onto the HIV-1 ..
  10. pmc Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
    N Dyson
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    J Virol 67:7641-7. 1993
    ..p107-associated proteins included cyclin A, cyclin E, and cdk2...
  11. pmc Tat protein induces self-perpetuating permissivity for productive HIV-1 infection
    C J Li
    Division of Cell Growth and Regulation, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA cjli mbcrr harvard edu
    Proc Natl Acad Sci U S A 94:8116-20. 1997
    ..Accordingly, these primary T cells progressed from G0 to the late G1 phase of the cell cycle...
  12. ncbi HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    M Kundu
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:8130-6. 1998
    ..Consistent with this observation, lower levels of cyclin E-Cdk2 kinase activity and phosphorylated Rb were detected in the Tat-treated cells compared with the control cells...
  13. pmc Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases
    I Blomberg
    Forschungsschwerpunkt Angewandte Tumorvirologie F0400, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell Biol 19:6183-94. 1999
    ..We further demonstrate that Cdc25A is activated at the same time as cyclin E- and cyclin A-dependent kinases...
  14. ncbi NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry
    A Boudrez
    Afdeling Biochemie and Center for Human Genetics VIB, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Belgium
    J Biol Chem 275:25411-7. 2000
    ..The binding of the FHA domain of NIPP1 to CDC5L was dependent on the phosphorylation of CDC5L, e.g. by cyclin E-Cdk2...
  15. ncbi Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
    P W Hinds
    Whitehead Institute, Cambridge, Massachusetts 02142
    Cell 70:993-1006. 1992
    ..in cells overexpressing these cyclins, and this phosphorylation is essential for cyclin A- and cyclin E-mediated rescue of pRb-blocked cells...
  16. ncbi Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
    A Koff
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Science 257:1689-94. 1992
    Human cyclin E, originally identified on the basis of its ability to function as a G1 cyclin in budding yeast, associated with a cell cycle-regulated protein kinase in human cells...
  17. ncbi Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast
    D J Lew
    Department of Molecular Biology, MB7 Scripps Research Institute, La Jolla, California 92037
    Cell 66:1197-206. 1991
    ..Cyclin C and E mRNAs accumulate periodically through the cell cycle, peaking at different times in G1...
  18. ncbi Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family
    A Koff
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 66:1217-28. 1991
    A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae...
  19. ncbi Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)
    D J Demetrick
    Howard Hughes Medical Institute, Cold Spring Harbor, NY, USA
    Cytogenet Cell Genet 69:190-2. 1995
    ..mapping by FISH of the genes for several cdk-associated proteins including human CCNC (cyclin C) to 6q21, CCNE (cyclin E) to 19q12-->q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22)...
  20. pmc Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
    M Ohtsubo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 15:2612-24. 1995
    b>Cyclin E was first identified by screening human cDNA libraries for genes that would complement G1 cyclin mutations in Saccharomyces cerevisiae and has subsequently been found to have specific biochemical and physiological properties that ..
  21. ncbi Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
    B E Clurman
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genes Dev 10:1979-90. 1996
    b>Cyclin E is a mammalian G1 cyclin that is both required and rate limiting for entry into S phase. The expression of cyclin E is periodic, peaking at the G1-S transition and then decaying as S phase progresses...
  22. ncbi Cyclin E-CDK2 is a regulator of p27Kip1
    R J Sheaff
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington 98104, USA
    Genes Dev 11:1464-78. 1997
    ..We show that expression of cyclin E-CDK2 in murine fibroblasts causes phosphorylation of the CDK inhibitor p27Kip1 on T187, and that cyclin E-CDK2 ..
  23. ncbi Cyclin E-induced S phase without activation of the pRb/E2F pathway
    J Lukas
    Danish Cancer Society, Division of Cancer Biology, Copenhagen
    Genes Dev 11:1479-92. 1997
    In cells of higher eukaryotes, cyclin D-dependent kinases Cdk4 and Cdk6 and, possibly, cyclin E-dependent Cdk2 positively regulate the G1- to S-phase transition, by phosphorylating the retinoblastoma protein (pRb), thereby releasing E2F ..
  24. pmc Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    J Vlach
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
    EMBO J 16:5334-44. 1997
    ..Through its intact cyclin contact, p27(k-) associated with active cyclin E-CDK2 and, unlike wild type p27, p27(c-) or p27(ck-), was efficiently phosphorylated by CDK2 on a conserved C-..
  25. ncbi Deregulated cyclin E induces chromosome instability
    C H Spruck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 401:297-300. 1999
    b>Cyclin E, a regulatory subunit of cyclin-dependent kinase 2 (Cdk2), is an important regulator of entry into S phase in the mammalian cell cycle...
  26. ncbi Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
    J W Harbour
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 98:859-69. 1999
    ..Cdk4/6 is activated early in G1, blocking active repression by Rb. However, it is not until near the end of G1, when cyclin E is expressed and Cdk2 is activated, that Rb is prevented from binding and inactivating E2F.
  27. pmc Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
    J D Singer
    Division of Basic Sciences, Howard Hughes Medical Institute, Seattle, Washington 98109 USA
    Genes Dev 13:2375-87. 1999
    b>Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380...
  28. pmc Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    K Nakayama
    Laboratory of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 19:2069-81. 2000
    ..Skp2(-/-) cells also exhibit increased accumulation of both cyclin E and p27(Kip1)...
  29. pmc Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells
    S Mazumder
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, OH 44195, USA
    Oncogene 19:2828-35. 2000
    b>Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2 (Cdk2)...
  30. ncbi Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    D M Koepp
    Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, 77030, USA
    Science 294:173-7. 2001
    b>Cyclin E binds and activates the cyclin-dependent kinase Cdk2 and catalyzes the transition from the G1 phase to the S phase of the cell cycle...
  31. ncbi Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
    K H Moberg
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Nature 413:311-6. 2001
    ..embryogenesis, exit from the cell cycle is contingent on tightly controlled downregulation of the activity of Cyclin E-Cdk2 complexes that normally promote the transition from G1 to S phase...
  32. ncbi Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
    H Strohmaier
    Department of Molecular Biology, MB 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 413:316-22. 2001
    b>Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the G1-S phase transition and is thought to be critical for the initiation of DNA replication and other S-phase functions...
  33. ncbi The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node
    Martin Lodén
    Department of Pathology, Umea University, S 901 87 Umea, Sweden
    Oncogene 21:4680-90. 2002
    ..cyclin D1 and elevated retinoblastoma protein (pRb) phosphorylation, (cyclin D1(high) tumours) or (2) with high cyclin E protein but low cyclin D1 and lack of corresponding pRb phosphorylation (cyclin E(high) tumours) indicative of an ..
  34. ncbi Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase
    Stephen Orlicky
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Ontario, Canada
    Cell 112:243-56. 2003
    ..A 2.7 A X-ray crystal structure of a Skp1-Cdc4 complex bound to a high-affinity CPD phosphopeptide from human cyclin E reveals a core CPD motif, Leu-Leu-pThr-Pro, bound to an eight-bladed WD40 propeller domain in Cdc4...
  35. ncbi Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
    Markus Welcker
    Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 12:381-92. 2003
    Autophosphorylation-triggered ubiquitination has been proposed to be the major pathway regulating cyclin E protein abundance: phosphorylation of cyclin E on T380 by its associated CDK allows binding to the receptor subunit, Fbw7, of the ..
  36. ncbi The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 303:1374-8. 2004
    ..SCF(Fbw7) therefore antagonizes the apoptotic c-Jun-dependent effector arm of JNK signaling, allowing neurons to tolerate potentially neurotoxic JNK activity...
  37. pmc A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy
    S Mazumder
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation NB40, Cleveland, OH 44195, USA
    Curr Cancer Drug Targets 4:65-75. 2004
    b>Cyclin E is essential for progression through the G1-phase of the cell cycle and initiation of DNA replication by interacting with and activating its catalytic partner, the cyclin dependent kinase 2 (Cdk2)...
  38. ncbi Inactivation of hCDC4 can cause chromosomal instability
    Harith Rajagopalan
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 428:77-81. 2004
    ..traced to a defect in the execution of metaphase and subsequent transmission of chromosomes, and is dependent on cyclin E--a protein that is regulated by hCDC4 (refs 2-4)...
  39. ncbi Cyclin E deregulation alters the biologic properties of ovarian cancer cells
    Isabelle Bedrosian
    Department of Surgical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Oncogene 23:2648-57. 2004
    We have previously shown that the low molecular weight (LMW) forms (trunk 1 and trunk 2) of cyclin E are biochemically hyperactive and induce G1/S progression in normal epithelial cells...
  40. pmc Deregulation of cyclin E in human cells interferes with prereplication complex assembly
    Susanna Ekholm-Reed
    Dept of Molecular Biology, MB 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Cell Biol 165:789-800. 2004
    Deregulation of cyclin E expression has been associated with a broad spectrum of human malignancies...
  41. ncbi Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase
    Xin Ye
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:50110-9. 2004
    Turnover of cyclin E is controlled by SCF(Fbw7). Three isoforms of Fbw7 are produced by alternative splicing...
  42. ncbi A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry
    Yutaka Matsumoto
    Howard Hughes Medical Institute HHMI and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Science 306:885-8. 2004
    Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells...
  43. ncbi The tumor-specific hyperactive forms of cyclin E are resistant to inhibition by p21 and p27
    Hannah Wingate
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    J Biol Chem 280:15148-57. 2005
    The low molecular weight (LMW) isoforms of cyclin E are unique to cancer cells. In breast cancer, such alteration of cyclin E is a very strong predictor of poor patient outcome...
  44. pmc Ras activity regulates cyclin E degradation by the Fbw7 pathway
    Alex C Minella
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:9649-54. 2005
    The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis...
  45. ncbi Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients
    Anieta M Sieuwerts
    Department of Medical Oncology, Erasmus MC, Rotterdam, The Netherlands
    Clin Cancer Res 12:3319-28. 2006
    To evaluate the prognostic value of cyclin E with a quantitative method for lymph node-negative primary breast cancer patients.
  46. ncbi Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation
    P Potemski
    Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
    J Exp Clin Cancer Res 25:59-64. 2006
    The main objective of this retrospective study was to investigate relations between cyclin E and pathoclinical factors in patients with operable breast cancer...
  47. ncbi Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms
    Frank van Drogen
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell 23:37-48. 2006
    b>Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4)...
  48. ncbi Kinase-independent function of cyclin E
    Yan Geng
    Department of Cancer Biology, Dana Farber Cancer Institute, USA
    Mol Cell 25:127-39. 2007
    ..We previously found that cyclin E-null cells failed to incorporate MCM helicase into DNA prereplication complex during G(0) --> S phase ..
  49. pmc Fbw7/hCDC4 dimerization regulates its substrate interactions
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, Washington 98109, USA
    Cell Div 2:7. 2007
    The Fbw7 ubiquitin ligase promotes the rapid degradation of several important oncogenes, such as cyclin E, c-Myc, c-Jun, and Notch. The two fission yeast homologs of Fbw7, pop1 and pop2, have previously been shown to dimerize...
  50. pmc Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas
    Yan Ma
    Department of Pharmacology and Toxicology, and Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 104:4089-94. 2007
    b>Cyclin E is a critical G(1)-S cell cycle regulator aberrantly expressed in bronchial premalignancy and lung cancer. Cyclin E expression negatively affects lung cancer prognosis. Its role in lung carcinogenesis was explored...
  51. ncbi Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases
    Bing Hao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 26:131-43. 2007
    The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer...
  52. pmc The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
    Benjamin J Thompson
    Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1825-35. 2007
    ..abrogate the binding of FBW7 not only to NOTCH1 but also to the two other characterized targets, c-Myc and cyclin E. The majority of the FBW7 mutations were present during relapse, and they were associated with NOTCH1 HD ..
  53. pmc Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)
    Jamie M Keck
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037
    J Cell Biol 178:371-85. 2007
    Overexpression of cyclin E, an activator of cyclin-dependent kinase 2, has been linked to human cancer...
  54. pmc Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort
    Elizabeth M Azzato
    Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, UK
    Breast Cancer Res 10:R47. 2008
    ..Of particular interest are genes involved in cell cycle pathways, which regulate cell division...
  55. pmc cAMP-mediated induction of cyclin E sensitizes growth-arrested adipose stem cells to DNA damage-induced apoptosis
    Hege Ugland
    Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
    Mol Biol Cell 19:5082-92. 2008
    ..Concomitantly, however, the level of cyclin E markedly increases upon cAMP induction, indicating that cyclin E may have cdk2-independent functions in these ..
  56. pmc Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation
    Anjanabha Saha
    Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 32:21-31. 2008
    ....
  57. doi Cyclin E deregulation is an early event in the development of breast cancer
    Alexandra Shaye
    Department of Pathology, University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Breast Cancer Res Treat 115:651-9. 2009
    b>Cyclin E has been shown to be overexpressed in some human breast cancers, however, data to support deregulation of cyclin E as an early event in human mammary tumor development is lacking...
  58. pmc Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 18:935-44. 2009
    ..These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls...
  59. pmc Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
    Roshan Agarwal
    The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
    Clin Cancer Res 15:3654-62. 2009
    ..We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling...
  60. doi Post-translational modification and stability of low molecular weight cyclin E
    B B Mull
    Department of Experimental Radiation Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 28:3167-76. 2009
    Our laboratory has previously described the presence of five tumor-specific low molecular weight isoforms of cyclin E in both tumor cell lines and breast cancer patient biopsies...
  61. doi A study of the expression of Cyclin E and its isoforms in tumor and adjacent mucosa, correlated to patient outcome in early colon cancer
    Irina Corin
    Department of Surgery, Sahlgrenska University Hospital Ostra, 41685 Gothenburg, Sweden
    Acta Oncol 49:63-9. 2010
    b>Cyclin E, a key regulator in the cell cycle, is often over-expressed in malignant disease. It can present as full length (FL) and low-molecular-weight (LMW) isoforms...
  62. doi Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer
    Naomi Nakayama
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Cancer 116:2621-34. 2010
    ..This study examined the clinical significance of CCNE1 (Cyclin E1) amplification and assessed whether CCNE1 is a potential therapeutic target in ovarian cancer...
  63. pmc A novel interaction between HER2/neu and cyclin E in breast cancer
    E A Mittendorf
    Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:3896-907. 2010
    HER2/neu (HER2) and cyclin E are important prognostic indicators in breast cancer. As both are involved in cell cycle regulation we analyzed whether there was a direct interaction between the two...
  64. pmc A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
    Nathaniel Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Nat Genet 42:978-84. 2010
    ..Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis...
  65. pmc Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation
    Nimesh Bhaskaran
    Department of Cell and Molecular Biology, The Karolinska Institute, Stockholm, Sweden
    Mol Cell Biol 33:85-97. 2013
    ..The ubiquitin ligase that targets phosphorylated cyclin E is SCF(Fbw7) (also known as SCF(Cdc4)), a member of the cullin ring ligase (CRL) family...
  66. pmc Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm
    Mark Jackman
    Wellcome Cancer Research U K London Institute and Department of Zoology, University of Cambridge, Cambridge, United Kingdom CB2 1QR
    Mol Biol Cell 13:1030-45. 2002
    ..However, recently, both cyclin A and cyclin E have been implicated as regulators of centrosome replication, and it is unclear when and where these cyclin-Cdks ..
  67. ncbi Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer
    Simon A Gayther
    Translational Research Laboratories, University College London, London, United Kingdom
    Cancer Res 67:3027-35. 2007
    ..This study highlights the need for multicenter collaborations for genetic association studies...
  68. pmc Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population
    Kristy E Driver
    Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK
    Carcinogenesis 29:333-41. 2008
    ..010, P-trend = 0.048). Further large-scale studies are needed to confirm these results...
  69. pmc Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival
    Honglin Song
    CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
    Clin Cancer Res 14:1090-5. 2008
    ..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types...
  70. doi Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
    Tobias Otto
    Institute of Molecular Biology and Tumor Research, Marburg, Germany
    Cancer Cell 15:67-78. 2009
    ..Aurora A interacts with both N-Myc and the SCF(Fbxw7) ubiquitin ligase that ubiquitinates N-Myc and counteracts degradation of N-Myc, thereby uncoupling N-Myc stability from growth factor-dependent signals...
  71. pmc Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E
    K A Won
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 15:4182-93. 1996
    A yeast screen was developed to identify mutations in human cyclin E that lead to stabilization of the protein in order to identify determinants important for cyclin E turnover...
  72. pmc Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
    Y Takano
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Am J Pathol 156:585-94. 2000
    ..We investigated overexpression of cyclin D1 (CCND1), cyclin D2 (CCND2), cyclin E (CCNE), CDK2, and CDK4, in addition to p27, in 260 gastric cancer cases on the basis of Western blots, reverse ..
  73. ncbi Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma
    Raul Cassia
    Laboratory of Breast and Gynaecological Cancer, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Pathol 201:589-95. 2003
    b>Cyclin E overexpression occurs in a subset of endometrial carcinomas (ECs), but the molecular mechanisms underlying this alteration remain to be established...
  74. ncbi Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
    M J Dealy
    Department of Biology, University of California, San Diego, California 92093 0366, USA
    Nat Genet 23:245-8. 1999
    ..We show that Cul1 is required for early mouse development and that Cul1 mutants fail to regulate the abundance of the G1 cyclin, cyclin E (encoded by Ccne), during embryogenesis.
  75. pmc Identification of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, Oncorhynchus kisutch
    John A Luckenbach
    School of Aquatic and Fishery Sciences, University of Washington, Seattle, Washington 98195, USA
    Reprod Biol Endocrinol 6:2. 2008
    ..The aim of this study was to identify differentially expressed ovarian genes during primary and early secondary oocyte growth in coho salmon, a semelparous teleost that exhibits synchronous follicle development...
  76. pmc Aberrant cell cycle progression and endoreplication in regenerating livers of mice that lack a single E-type cyclin
    Yulia A Nevzorova
    Department of Medicine III, University Hospital Aachen, RWTH Aachen University, Aachen, Germany
    Gastroenterology 137:691-703, 703.e1-6. 2009
    ..We investigated the relevance of E-cyclins in directing resting hepatocytes into the cell cycle after partial hepatectomy using CcnE1 and CcnE2 knockout mice...
  77. ncbi Sporadic invasive breast carcinomas with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification study
    Socorro Maria Rodriguez-Pinilla
    Breast and Gynecological Cancer Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Am J Surg Pathol 31:501-8. 2007
    ..In addition, we analyzed EGFR, C-MYC, and CCNE gene amplification by fluorescence in situ hybridization, because the expression of these genes is known to be ..
  78. ncbi Deregulation of the G1/S phase transition in cancer and squamous intraepithelial lesions of the uterine cervix: a case control study
    Demetrios A Arvanitis
    Molecular Biology Division, Biomedical Research Foundation, Academy of Athens, Athens, Greece
    Oncol Rep 20:751-60. 2008
    ..The ability of this array of markers to identify disease status suggests that it could be used for diagnostic purposes...
  79. pmc Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: a multiplex ligation-dependent probe amplification study
    Cathy B Moelans
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Anal Cell Pathol (Amst) 33:165-73. 2010
    ..These high-grade DCIS specific genes may be potential targets for treatment and/or predict progression...
  80. doi Effect of prostaglandin on luteinizing hormone-stimulated proliferation of theca externa cells from chicken prehierarchical follicles
    Yudong Jia
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou 310029, China
    Prostaglandins Other Lipid Mediat 92:77-84. 2010
    ..These results suggest that PG may promote development of chicken prehierarchical follicles and is related to dominant follicle selection in laying hens...
  81. doi Potentially functional polymorphisms in cell cycle genes and the survival of non-small cell lung cancer in a Chinese population
    Hongxia Ma
    Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, China
    Lung Cancer 73:32-7. 2011
    ..Further large and functional studies are needed to confirm our findings...
  82. ncbi Community-based nursing education and nursing accreditation by the Commission on Collegiate Nursing Education
    S Van Ort
    College of Nursing, University of Arizona, Tucson, AZ, USA
    J Prof Nurs 16:330-5. 2000
    ..is to describe the application of accreditation standards of the Commission on Collegiate Nursing Education (CCNE) in community-based nursing education...
  83. doi Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes
    Cathy B Moelans
    Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Mod Pathol 23:1029-39. 2010
    ....
  84. doi Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia
    Andrea Caporali
    Regenerative Medicine, School of Clinical Medicine, University of Bristol, Bristol, England, UK
    Circulation 123:282-91. 2011
    ..microRNAs negatively regulate the expression of target genes mainly by interaction in their 3' untranslated region...
  85. ncbi Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 75:342-51. 2006
    ..Metformin treatment (10 mM, 24 h) also reduced cell proliferation and the levels of CCND2 and CCNE proteins without affecting cell viability, both in the basal state and in response to FSH...
  86. ncbi Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression
    James Adjaye
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Physiol Genomics 31:315-27. 2007
    ....
  87. pmc Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cells
    Y Choi
    College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151 742, Korea
    Br J Pharmacol 157:1053-64. 2009
    ....
  88. pmc Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    Tiziana Parisi
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    EMBO J 22:4794-803. 2003
    In mammalian cells, cyclin E-CDK2 complexes are activated in the late G1 phase of the cell cycle and are believed to have an essential role in promoting S-phase entry...
  89. doi Gene networks involved in apoptosis induced by hyperthermia in human lymphoma U937 cells
    Yukihiro Furusawa
    Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Cell Biol Int 33:1253-62. 2009
    ..These findings will provide a basis for understanding the detailed molecular mechanisms of apoptosis induced by hyperthermia at 42 degrees C in cells...
  90. ncbi Down-regulation of the cyclin E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells
    Fu Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, P R China
    BMB Rep 42:725-30. 2009
    ..Together, all these results demonstrate that miR-16-1 plays a vital role in modulating cellular process in human cancers and indicate the therapeutic potential of miR-16-1 in cancer therapy...
  91. pmc Amplicon-dependent CCNE1 expression is critical for clonogenic survival after cisplatin treatment and is correlated with 20q11 gain in ovarian cancer
    Dariush Etemadmoghadam
    Cancer Genomics Program, Peter MacCallum Cancer Centre, East Melbourne, Australia
    PLoS ONE 5:e15498. 2010
    ..Co-amplification at 19q12 and 20q11 implies the presence of a cooperative mutational network. These observations have implications for the application of targeted therapies in CCNE1 dependent ovarian cancers...
  92. ncbi MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1369-74. 2003
    ..This is the first report on comprehensive characterization of the amplicon around the PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12...
  93. ncbi The FBXW7 beta-form is suppressed in human glioma cells
    Zhaodi Gu
    Department of Molecular Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Sendai, Japan
    Biochem Biophys Res Commun 354:992-8. 2007
    ..Our present results imply that FBXW7 plays a pivotal role in many tissues by controlling the amount of cell cycle promoter proteins and that dysfunction of this protein is one of the essential steps in carcinogenesis in multiple organs...
  94. ncbi Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women
    Andrea L Niklaus
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Reprod 22:1778-88. 2007
    ....
  95. doi Frequent amplifications and deletions of G1/S-phase transition genes, CCND1 and MYC in early breast cancers: a potential role in G1/S escape
    L B Jensen
    Endocrine Cancer Group, Edinburgh Cancer Research Centre, Western General Hospital, Edinburgh, UK
    Cancer Biomark 5:41-9. 2009
    ..Both markers were amplified in 14% and deleted in 5% of the cases. This is the first report of genomic deletions of MYC in breast cancer...
  96. doi Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study
    Andreas Gast
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 49:733-45. 2010
    ....
  97. doi Genetic variants in urinary bladder cancer: collective power of the "wimp SNPs"
    Klaus Golka
    Leibniz Research Centre for Working Environment and Human Factors, Ardeystrasse 67, 44139, Dortmund, Germany
    Arch Toxicol 85:539-54. 2011
    ..In future, besides identifying novel disease-associated rare variants by deep sequencing, it will also be important to understand how the already identified variants interact...
  98. ncbi Rescue of cyclin D1 deficiency by knockin cyclin E
    Y Geng
    Dana Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:767-77. 1999
    D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins...
  99. pmc BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets
    Eric S Calhoun
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Am J Pathol 163:1255-60. 2003
    ..This study investigated the mutational status of the serine/threonine kinase BRAF and the cyclin E regulator FBXW7 (CDC4, FBW7, AGO, SEL10) related to two distinct pancreatic carcinoma subsets: the medullary ..
  100. pmc Identification of a three-gene expression signature of poor-prognosis breast carcinoma
    Ivan Bieche
    Laboratoire d Oncogénétique INSERM E0017, Centre Rene Huguenin, St Cloud, France
    Mol Cancer 3:37. 2004
    ..The use of gene expression profiles could result in more accurate and objective prognostication...
  101. pmc Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression
    Shugaku Takeda
    Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 20:2397-409. 2006
    ..Lastly, Taspase1(-/-) cells are resistant to oncogenic transformation, and Taspase1 is overexpressed in many cancer cell lines. Thus, Taspase1 may serve as a target for cancer therapeutics...

Research Grants23

  1. Center of Cancer Nanotechnology Excellence Focused on Therapy Response
    Sanjiv S Gambhir; Fiscal Year: 2010
    This Center for Cancer Nanotechnology Excellence focused on therapy response (CCNE-TR) brings together scientists and physicians from Stanford University, University of California Los Angeles (UCLA), Cedars Sinai Medical Center, Fredrick ..
  2. Enzyme-Responsive Nanoemulsions as Tumor-Specific Ultrasound Contrast Agents for
    Andrew P Goodwin; Fiscal Year: 2011
    ..He then continued to the Stanford University CCNE in the labs of Prof...
  3. Emory-GA Tech Nanotechnology Center for Personalized an*
    Shuming Nie; Fiscal Year: 2009
    This application proposes a cross-disciplinary Center of Cancer Nanotechnology Excellence (CCNE) at Emory University and Georgia Tech that will integrate nanotechnology with cancer biomolecular signatures (biomarkers) for personalized and ..
  4. Andrew P Goodwin; Fiscal Year: 2014
    ..He then continued to the Stanford University CCNE in the labs of Prof...
  5. Lily Yang; Fiscal Year: 2014
    ..Our extensive research supported by NCI CCNE program led to the development of biodegradable and receptor targeted magnetic iron oxide nanoparticles (lONP) as a ..
  6. Carolina Center of Cancer Nanotechnology Excellence
    Rudolph Juliano; Fiscal Year: 2009
    DESCRIPTION (provided by the applicant): The Carolina Center of Cancer Nanotechnology Excellence (C-CCNE) will bring together recent pioneering breakthroughs at UNC in nano-particle engineering with the world class excellence in the ..
  7. Sanjiv S Gambhir; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): This Center for Cancer Nanotechnology Excellence and Translation (CCNE-T) brings together scientists and physicians from Stanford University, University of California Berkeley/Lawrence Berkeley ..
  8. SANDY A NAPEL; Fiscal Year: 2016
    ..Cellular and Molecular Imaging Center (ICMIC), the Center for Cancer Nanotechnology Excellence and Translation (CCNE-T), the Center for Advanced Magnetic Resonance Technology (CAMRT), and the Stanford Center for Cancer Systems ..
  9. Sanjiv S Gambhir; Fiscal Year: 2015
    ..the Canary Foundation, and the National Cancer Institute, including a center for cancer nanotechnology excellence (CCNE) U54 and an in vivo cellular and molecular imaging center (ICMIC) P50...
  10. Nanomaterials for Cancer Diagnostics and Therapeutics
    Chad Mirkin; Fiscal Year: 2009
    ..of a Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence (CCNE). To be led by the Principal Investigator, Chad A...
  11. MOLECULAR BASES OF CELL ADHESION
    Rudolph Juliano; Fiscal Year: 2003
    ....
  12. Enhanced Delivery of Protein Biosensors: a Combinatorial Library Strategy
    Rudolph Juliano; Fiscal Year: 2009
    ..We anticipate that this approach will lead to a cohort of novel CPPs that will have an important impact on the entire field of intracellular delivery of proteins, especially biosensors. ..
  13. Cytotoxic lymphocytes in acute lung injury
    Mitzi Nagarkatti; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. Pathogenesis of HIVAN: the role of Nef
    JOHN HE; Fiscal Year: 2007
    ..These studies should elucidate essential mechanism responsible for the development of HIV-associated nephropathy and how Nef plays a role in this pathologic process. ..
  15. Role of CD44 in EC injury and melanoma therapy
    Mitzi Nagarkatti; Fiscal Year: 2007
    ..The proposed studies also form the basis for prventing EC injury in wide range of clinical manifestations. ..
  16. Major Challenges in Clinical Medicine: An Overview for *
    Rudolph Juliano; Fiscal Year: 2006
    ..As part of this component the trainee, with the mentor's guidance, will prepare the Abstract and Specific Aims of an NIH-type grant proposal dealing with a translational research topic. ..
  17. TARGETING CANCER CELL DNA WITH COMBINATORIAL LIGANDS
    Rudolph Juliano; Fiscal Year: 2005
    ..They will also provide new molecular tools that could prove to be valuable adjuncts for cancer chemotherapy. ..
  18. Conference on Signaling Via Cell-Cell Interactions
    Rudolph Juliano; Fiscal Year: 2003
    ..The proposed program will present a unique training opportunity for students and post-doctoral fellows, since it will provide a unifying thematic structure to converging, but still disparate, areas of research. ..
  19. The role of Cyclin E in growth control and tumorogenesis
    Steven Reed; Fiscal Year: 2008
    b>Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2) is a positive activator of the G1-S phase transition in proliferating mammalian cells and therefore serves an important function during development and in replenishment of tissues...
  20. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2007
    ..To understand how cyclin E-Cdk2, a key CDK required for the G1-to-S phase transition, executes its function in vivo, we developed a strategy ..
  21. THE S. CEREVISIAE S PHASE CHECKPOINT
    Steven Reed; Fiscal Year: 2003
    ....
  22. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2008
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..