cyclin D3

Summary

Gene Symbol: cyclin D3
Description: cyclin D3
Alias: G1/S-specific cyclin-D3, D3-type cyclin
Species: human

Top Publications

  1. pmc Cyclin-binding motifs are essential for the function of p21CIP1
    J Chen
    Department of Pathology, Division of Molecular Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:4673-82. 1996
  2. ncbi New functional activities for the p21 family of CDK inhibitors
    J LaBaer
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 11:847-62. 1997
  3. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
  4. ncbi Induction and expression of cyclin D3 in human pancreatic cancer
    M P Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Germany
    J Cancer Res Clin Oncol 127:449-54. 2001
  5. ncbi Regulation of the cyclin D3 promoter by E2F1
    Yihong Ma
    Program in Molecular Oncology, H Lee Moffitt Comprehensive Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 278:16770-6. 2003
  6. pmc Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"
    Laurence Bockstaele
    Institute of Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, B 1070 Brussels, Belgium
    Mol Cell Biol 26:5070-85. 2006
  7. pmc MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma
    Wen Wang
    Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China
    Carcinogenesis 33:1113-20. 2012
  8. ncbi Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
  9. pmc Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    Xin Yan Lu
    Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Mol Cancer Res 6:937-46. 2008
  10. pmc CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    Eric D Hsi
    Clinical Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Cancer Res 14:2775-84. 2008

Research Grants

  1. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
  2. Molecular Pathogenesis of Multiple Myeloma
    Peter Leif Bergsagel; Fiscal Year: 2013
  3. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications186 found, 100 shown here

  1. pmc Cyclin-binding motifs are essential for the function of p21CIP1
    J Chen
    Department of Pathology, Division of Molecular Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:4673-82. 1996
    ..The Cy sequences may be general motifs used by Cdk inhibitors or substrates to interact with the cyclin in a cyclin-Cdk complex...
  2. ncbi New functional activities for the p21 family of CDK inhibitors
    J LaBaer
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 11:847-62. 1997
    ..We suggest that in addition to their roles as inhibitors, the p21 family of proteins, originally identified as inhibitors, may also have roles as adaptor proteins that assemble and program kinase complexes for specific functions...
  3. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
    ..We have found that the Cdk6-cyclin D3 complex is unique among the D cyclin and kinase combinations in the ability to promote the cell cycle start...
  4. ncbi Induction and expression of cyclin D3 in human pancreatic cancer
    M P Ebert
    Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University of Magdeburg, Germany
    J Cancer Res Clin Oncol 127:449-54. 2001
    ..Cyclins play a key role in the control and regulation of the cell cycle. The role of cyclins in the pathogenesis of pancreatic cancer is largely unknown...
  5. ncbi Regulation of the cyclin D3 promoter by E2F1
    Yihong Ma
    Program in Molecular Oncology, H Lee Moffitt Comprehensive Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 278:16770-6. 2003
    ..In the present work, we present novel evidence that a second G(1) cyclin, cyclin D3, is also potently activated by E2F1...
  6. pmc Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"
    Laurence Bockstaele
    Institute of Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, B 1070 Brussels, Belgium
    Mol Cell Biol 26:5070-85. 2006
    ..Opposite effects of p27 on cyclin D3-CDK4 activity observed in different systems depended on its stoichiometry in this complex...
  7. pmc MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma
    Wen Wang
    Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China
    Carcinogenesis 33:1113-20. 2012
    ..We conclude that the frequently downregulated miR-138 can regulate CCND3 and function as a tumor suppressor in HCC. Therefore, miR-138 may serve as a useful therapeutic agent for miRNA-based HCC therapy...
  8. ncbi Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
    T Inaba
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 13:565-74. 1992
    ..gene symbol, CCND1) was assigned to chromosome band 11q13, cyclin D2 (CCND2) to chromosome band 12p13, and cyclin D3 (CCND3) to chromosome band 6p21...
  9. pmc Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma
    Xin Yan Lu
    Texas Children s Cancer Center, Baylor College of Medicine, 6621 Fannin Street, MC 3 3320, Houston, TX 77030, USA
    Mol Cancer Res 6:937-46. 2008
    ..These results indicate that CDC5L, a cell cycle regulator important for the G2-M transition, is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma...
  10. pmc CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma
    Eric D Hsi
    Clinical Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Cancer Res 14:2775-84. 2008
    ....
  11. doi High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle
    Alex J Tipping
    Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
    Blood 113:2661-72. 2009
    ..Thus, GATA-2 activity inhibits cell cycle in vitro and in vivo, highlighting GATA-2 as a molecular entry point into the transcriptional program regulating quiescence in human hematopoietic stem and progenitor cells...
  12. pmc Oligonucleotide microarray analysis of apoptosis induced by 15-methoxypinusolidic acid in microglial BV2 cells
    Y Choi
    College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151 742, Korea
    Br J Pharmacol 157:1053-64. 2009
    ....
  13. ncbi Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3
    Matthew L Smith
    Cancer Research UK Medical Oncology Unit, Charterhouse Square, Barts and the London School of Medicine and Dentistry, London
    Br J Haematol 128:318-23. 2005
    ..A 51-bp deletion was detected in CCND3 in a patient with normal karyotype AML. This validated panel now provides an important tool to evaluate other candidate genes in the genesis of myeloid malignancy...
  14. doi Close relation between 14q32/IGH translocations and chromosome 13 abnormalities in multiple myeloma: a high incidence of 11q13/CCND1 and 16q23/MAF
    Madoka Takimoto
    Department of Internal Medicine, Division of Hematology and Oncology, St Marianna University School of Medicine, Kawasaki, Kanagawa, 218 8511, Japan
    Int J Hematol 87:260-5. 2008
    ..Our results suggest a significant correlation between the presence of 14q32/IGH translocations and chromosome 13 abnormalities (P = 0.0276) in MM patients...
  15. pmc Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors
    Ana Gabrea
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA
    Genes Chromosomes Cancer 47:573-90. 2008
    ..We conclude that IG light chain and MYC rearrangements, as well as secondary IGH rearrangements, make similar contributions to the progression of both HRD and NHRD MM tumors...
  16. pmc Predicting recurrence and progression of noninvasive papillary bladder cancer at initial presentation based on quantitative gene expression profiles
    Marc Birkhahn
    Department of Urology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Eur Urol 57:12-20. 2010
    ..However, reliable predictors of Ta tumor recurrence and progression for individual patients, which could optimize treatment and follow-up schedules based on specific tumor biology, are yet to be identified...
  17. ncbi Elicitor-induced down-regulation of cell cycle-related genes in tobacco cells
    Kaoru Suzuki
    Molecular and Cellular Breeding Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 6, 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Plant Cell Environ 29:183-91. 2006
    ..Finally, we discuss a negative cross-talk between signal transduction pathways for growth and defence responses, which might be important for adaptation to environmental stress by potential pathogens...
  18. ncbi FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
    Li Li
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Br J Haematol 137:64-75. 2007
    ..The FLT3/ITD-transduced HSPCs showed increased expression of Pim-1, c-Myc and Cyclin D3 (CCND3), each of which may contribute to the altered genetic programme instituted by FLT3/ITD signalling...
  19. ncbi Multicolor interphase cytogenetics for the study of plasma cell dyscrasias
    Borja Saez
    Department of Genetics, University of Navarra, 31008 Pamplona, Navarra, Spain
    Oncol Rep 18:1099-106. 2007
    ....
  20. pmc NF-kappa B genes have a major role in inflammatory breast cancer
    Florence Lerebours
    Centre Rene Huguenin, FNCLCC, 35 rue Dailly, 92210, St Cloud, France
    BMC Cancer 8:41. 2008
    ..Given the role of NF-kappaB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC...
  21. pmc Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis
    J M Cunningham
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Br J Cancer 101:1461-8. 2009
    ..Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide...
  22. pmc Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells
    Sonia Cellot
    Laboratory of Molecular Genetics of Stem Cells, Institute for Research in Immunology and Cancer IRIC, Montreal, QC, Canada
    Exp Hematol 35:802-16. 2007
    ..in Hoxb4hiPbxl(l0) primitive cells, accompanied by a more subtle increase in c-myc and reduction in Ccnd3 (Cyclin D3)...
  23. ncbi Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells
    Kyu Tae Kim
    Department of Oncology, Johns Hopkins University School of Medicine, Bethesda, MD, USA
    Br J Haematol 138:603-15. 2007
    ..The alterations of the gene expression profiles in these cells help to further elucidate the mechanisms of FLT3-mediated leukaemogenesis...
  24. doi cDNA cloning, sequence identification and tissue expression distribution of three novel porcine genes: UCHL3, RIT1 and CCND3
    G Y Liu
    Key Laboratory of Animal Nutrition and Feed of Yunnan Province, Yunnan Agricultural University, Kunming, China
    Mol Biol Rep 36:521-8. 2009
    ..Our experiment established the primary foundation for further research on these three swine genes...
  25. pmc Requirement for cyclin D3 in germinal center formation and function
    Jonathan U Peled
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell Res 20:631-46. 2010
    ..In this study, we report that cyclin D3 is largely dispensable for proliferation and Ig class switching of in vitro activated B cells...
  26. doi Cyclin D3 gene amplification in bladder carcinoma in situ
    Antonio Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Spain
    Virchows Arch 457:555-61. 2010
    ..The aim of this study was to assess patterns of Cyclin D3 gene amplification in Bacillus Calmette-Guerin (BCG)-treated CIS and correlate gene status with recurrence-free ..
  27. doi CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus
    Shirley Michelle Shiller
    Department of Pathology, Baylor University Medical Center, Dallas, TX, USA
    Cancer Genet 204:162-4. 2011
    ..Clinical workup revealed stage IV disease. Current diagnostic criteria are insufficient for subclassifying this case, highlighting the need for additional studies on CCND2-translocated B-cell lymphomas to guide therapy appropriately...
  28. pmc MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion
    Qian Qian Zhang
    Corresponding Author Liang Hu Qu, Sun Yat Sen University, 135 Xingangxi Road, Guangzhou 510275, PR China
    Neuro Oncol 14:278-87. 2012
    ....
  29. doi BCR-ABL/GATA1/miR-138 mini circuitry contributes to the leukemogenesis of chronic myeloid leukemia
    C Xu
    Department of Hematology, Chinese PLA General Hospital, Beijing, China
    Oncogene 33:44-54. 2014
    ..Therefore, miR-138, by virtue of a BCR-ABL/GATA1/miR-138 circuitry, is a tumor suppressor miRNA implicated in the pathogenesis of CML and its clinical response to imatinib. ..
  30. pmc Gene expression profiling to predict and assess the consequences of therapy-induced virus eradication in chronic hepatitis C virus infection
    Jun Hou
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Virol 88:12254-64. 2014
    ..The altered transcriptional activity may reflect HCV-induced liver damage in previously infected individuals...
  31. pmc Identification of G1 kinase activity for cdk6, a novel cyclin D partner
    M Meyerson
    Massachusetts General Hospital Cancer Center, Charlestown 02129
    Mol Cell Biol 14:2077-86. 1994
    ..This timing suggests that cdk6, and by analogy its homolog cdk4, links growth factor stimulation with the onset of cell cycle progression...
  32. pmc Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo
    E Gómez Lahoz
    Department of Microbiology and Immunology and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Cell Biol 19:353-63. 1999
    ....
  33. ncbi Glucocorticoid-mediated destabilization of cyclin D3 mRNA involves RNA-protein interactions in the 3'-untranslated region of the mRNA
    E A Garcia-Gras
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 0645, USA
    J Biol Chem 275:22001-8. 2000
    Glucocorticoids regulate the expression of the G(1) progression factor, cyclin D3. Cyclin D3 messenger RNA (CcnD3 mRNA) stability decreases rapidly when murine T lymphoma cells are treated with the synthetic glucocorticoid dexamethasone...
  34. ncbi Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27
    T Decker
    Third Department of Medicine, Technical University of Munich, Munich, Germany
    Leukemia 16:327-34. 2002
    ..b>Cyclin D3 is the principal D-type cyclin which mediates G1 progression in normal B cells, but in B-CLL cells both cyclin ..
  35. ncbi Profiling of genes differentially expressed between fetal liver and postnatal liver using high-density oligonucleotide DNA array
    Toshihito Nagata
    Department of Advanced Medicine, Nihon University, School of Medicine, Itabashi ku, Tokyo 173 8610, Japan
    Int J Mol Med 11:713-21. 2003
    ..The 33 genes identified in this study are suggested to be useful markers clearly discriminating between FL and PNL using the gene expression profile...
  36. ncbi Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations
    Luca Agnelli
    UO Ematologia 2, Centro G Marcora, Ospedale Maggiore Policlinico IRCCS, Dipartimento Scienze Mediche, Universita degli Studi di Milano, Via Francesco Sforza 35, 20122 Milano, Italy
    J Clin Oncol 23:7296-306. 2005
    ..In this study, we provide a molecular characterization of the identified translocations/cyclins (TC) groups...
  37. doi Site-dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissue of patients with type 2 familial partial lipodystrophy
    D Araujo-Vilar
    Thyroid and Metabolic Diseases Unit UETeM, Department of Medicine, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    J Med Genet 46:40-8. 2009
    ..Type 2 familial partial lipodystrophy (FPLD2) is characterised by loss of fat in the limbs and buttocks and results from mutations in the LMNA gene...
  38. pmc Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context
    Laura Chiecchio
    Leukaemia Research Fund UK Myeloma Forum Cytogenetics Group, Human Genetics Division, University of Southampton, Wessex Regional Genetics Laboratory, Salisbury District Hospital, Wilts, UK
    Haematologica 94:1708-13. 2009
    ..We investigated these aspects in a large series of patients...
  39. pmc Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma
    Nikolina Radulovich
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada
    Mol Cancer 9:24. 2010
    The cyclin D1 (CCND1) and cyclin D3 (CCND3) are frequently co-overexpressed in pancreatic ductal adenocarcinoma (PDAC). Here we examine their differential roles in PDAC.
  40. pmc In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms
    Elisa Lupino
    Department of Medicine and Experimental Oncology, Section of Biochemistry, University of Turin, Turin, Italy
    Immunology 131:231-41. 2010
    ..of the TCR and the CD28 co-receptor, IKK controls the expression of the cell cycle regulatory proteins cyclin D3, cyclin E and cyclin-dependent kinase 2 (CDK2) and the stability of the F-box protein S-phase kinase-associated ..
  41. pmc Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells
    Masao Nakagawa
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
    Haematologica 96:1318-26. 2011
    ..First, we assessed whether Bcl2, Myc and Ccnd1 could cooperate. Next, we developed a synergism-based functional screening method for the identification of other oncogene(s) that act with Bcl2 and Myc...
  42. pmc PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development
    Ram K C Venigalla
    MRC Protein Phosphorylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, UK
    EMBO J 32:1008-22. 2013
    ..Reintroduction of both Pax5 and Bcl2A1 together into PDK1 knockout pro-B cells restored their ability to differentiate in vitro into mature B cells...
  43. doi Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization
    T Rivera Vargas
    1 CNRS, FRE 3377, Gif sur Yvette, France 2 Univ Paris Sud, FRE 3377, Gif sur Yvette, France 3 CEA, FRE 3377, Gif sur Yvette, France
    Oncogene 33:2866-75. 2014
    ..In conclusion, a nuclear IMP-3-HNRNPM complex is important for the efficient synthesis of CCND1, D3 and G1 and for the proliferation of human cancer cells...
  44. doi Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy
    Jeffrey S Ross
    1 Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA 2 Foundation Medicine, Cambridge, MA, USA
    Mod Pathol 27:271-80. 2014
    ..Comprehensive NGS of 35 UCs of the bladder revealed a diverse spectrum of actionable GAs in 83% of cases, which has the potential to inform treatment decisions for patients with relapsed and metastatic disease. ..
  45. pmc Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer
    Nicolas Bovy
    Laboratory of Molecular Angiogenesis, GIGA R, University of Liege, Belgium
    Oncotarget 6:10253-66. 2015
    ..Taken together, our data are the first to reveal the involvement of the endothelium in the modulation of tumor development via the secretion of circulating miR-503 in response to chemotherapy treatment. ..
  46. doi Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options
    Jeffrey S Ross
    From the Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York Drs Ross and Boguniewicz and Ms Sheehan Research and Development, Foundation Medicine, Inc, Cambridge, Massachusetts Drs Ross, Wang, Otto, Yelensky, Lipson, Ali, Morosini, Chliemlecki, Elvin, Miller, and Stephens and the Department of Pathology, University of Indiana School of Medicine, Indianapolis Dr Badve
    Arch Pathol Lab Med 139:642-9. 2015
    ..Metastatic metaplastic breast carcinoma (MPBC) is an uncommon, but aggressive, tumor resistant to conventional chemotherapy...
  47. doi MicroRNA library screening identifies growth-suppressive microRNAs that regulate genes involved in cell cycle progression and apoptosis
    Young Chul Choi
    Graduate School of Biotechnology, Kyung Hee University, Yongin, Republic of Korea
    Exp Cell Res 339:320-32. 2015
    ..These findings provide insights into the roles of five miRNAs in growth inhibition and their potential function as cancer therapeutics. ..
  48. doi Identification of the potential biomarkers for the metastasis of rectal adenocarcinoma
    Yang Hua
    Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China
    APMIS . 2016
    ..The five genes could be potential diagnosis biomarkers or therapeutic targets for RAC metastasis...
  49. pmc Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3
    Y Kawaguchi
    The Marjorie B Kovler Viral Oncology Laboratories, The University of Chicago, Illinois 60637, USA
    J Virol 71:7328-36. 1997
    ..Our results were as follows. (i) A cDNA in a positive yeast colony was found to encode cyclin D3, a cell cycle regulator of G1 phase...
  50. ncbi Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
    Paula M De Angelis
    Institute of Pathology, Norwegian National Hospital, N 0027 Oslo, Norway
    Int J Oncol 24:1279-88. 2004
    ..Development of 5-FU resistance thus appears to encompass deregulation of apoptosis-, proliferation-, DNA repair-, and metastasis-associated regulatory pathways...
  51. pmc The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3
    Luke F Peterson
    Dept of Molecular Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 25:10205-19. 2005
    ..We identified cyclin D3 by a yeast two-hybrid screen and detected AML1 interaction with the cyclin D family by both in vitro pull-down ..
  52. ncbi Genetic alterations (amplification and rearrangement) of D-type cyclins loci in head and neck squamous cell carcinoma of Indian patients: prognostic significance and clinical implications
    Md Golam Sabbir
    Chittaranjan National Cancer Institute, Kolkata, India
    Diagn Mol Pathol 15:7-16. 2006
    ....
  53. ncbi Comparative transcript profiles of cell cycle-related genes in mouse primordial germ cells, embryonic stem cells and embryonic germ cells
    Eleonora Sorrentino
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    Gene Expr Patterns 7:714-21. 2007
    ..Moreover, our data provide useful clues for further studies aimed at identifying cell cycle genes critical for PGC growth and their transformation in tumorigenic cells...
  54. doi Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors
    Christina Justenhoven
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Int J Cancer 124:2077-81. 2009
    ..We conclude that the analyzed polymorphisms located in E2F2, CCND1 and CCND3 are potential markers for HER2 status of breast tumors...
  55. doi An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
    Balazs Gyorffy
    Joint Research Laboratory of the Hungarian Academy of Sciences and the Semmelweis University, Semmelweis University 1st Department of Pediatrics, Bókay u 53 54, 1083, Budapest, Hungary
    Breast Cancer Res Treat 123:725-31. 2010
    ..The tool is highly valuable for the preliminary assessment of biomarkers, especially for research groups with limited bioinformatic resources...
  56. pmc Cyclin D3 is selectively required for proliferative expansion of germinal center B cells
    Matthew H Cato
    Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 31:127-37. 2011
    ..Here, we report that cyclin D3 is uniquely required for germinal center progression...
  57. pmc Translational repression of cyclin D3 by a stable G-quadruplex in its 5' UTR: implications for cell cycle regulation
    Heng You Weng
    Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat Sen University, Guangzhou, China
    RNA Biol 9:1099-109. 2012
    b>cyclin D3 (CCND3) is one of the three D-type cyclins that regulate the G1/S phase transition of the cell cycle...
  58. doi Transcriptional regulatory networks in human lung adenocarcinoma
    Xiangrui Meng
    Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China
    Mol Med Rep 6:961-6. 2012
    ..growth factor, β receptor II (TGFBR2) expression to activate TGF-β signaling and upregulates cyclin D3 (CCND3) expression to promote the cell cycle pathway; NFKB1 upregulates interleukin 1, β (IL-1B) ..
  59. pmc Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number
    Vijay G Sankaran
    Broad Institute, Cambridge, Massachusetts 02142, USA
    Genes Dev 26:2075-87. 2012
    ..By examining human and mouse primary erythroid cells, we demonstrate that the CCND3 gene product cyclin D3 regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation, ..
  60. ncbi Fluorescence in situ hybridization analysis of CCND3 gene as marker of progression in bladder carcinoma
    A L Beltran
    Department of Surgery and Pathology, Cordoba University Medical School, Cordoba, Spain
    J Biol Regul Homeost Agents 27:559-67. 2013
    ..25 months) as compared to 33.29+-11.0 months in the CCND3 not amplified group (p=0.05). By immunohistochemistry, Cyclin D3 labeling index was higher in the CCND3 amplified group (mean+-SD, 76.69+-27...
  61. doi Overexpression of AIOLOS inhibits cell proliferation and suppresses apoptosis in Nalm-6 cells
    Yong Zhuang
    Department of Pediatrics, Qilu Hospital, Shandong University, Ji Nan, Shandong 250012, P R China
    Oncol Rep 31:1183-90. 2014
    ..Our findings indicate that lentivirus-mediated overexpression of AIOLOS in Nalm-6 cells could inhibit cell proliferation, suppress cell apoptosis and arrest the cell cycle at the G0/G1 phase in vitro...
  62. doi The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer
    Y Kim
    Division of Life Sciences, Korea University, Seoul, South Korea
    Oncogene 34:226-36. 2015
    ..b>Cyclin D3 is known to interact with AR and attenuates the ligand-dependent function of AR in PCa cells...
  63. doi High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS
    Seval Turkmen
    Labor Berlin, Tumorzytogenetik, Berlin, Germany Institut für Medizinische Genetik und Humangenetik, Charite, CVK, Berlin, Germany
    Genes Chromosomes Cancer 53:650-6. 2014
    ..6%). In 6 of 18 patients with IGK or/and IGL rearrangements, we detected a MYC rearrangement which suggests that MYC is the translocation partner in the majority of these cases...
  64. doi PLCβ1a and PLCβ1b selective regulation and cyclin D3 modulation reduced by kinamycin F during k562 cell differentiation
    Alberto Bavelloni
    SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy Laboratory RAMSES, Rizzoli Orthopedic Institute, Bologna, Italy
    J Cell Physiol 230:587-94. 2015
    ..Moreover during K562 differentiation, cyclin D3 level is regulated by PLCβ1 signaling pathway...
  65. doi Clinical significance of microRNA 138 and cyclin D3 in hepatocellular carcinoma
    Bo Huang
    the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
    J Surg Res 193:718-23. 2015
    ..shown to inhibit tumor growth and block cell cycle arrest of hepatocellular carcinoma (HCC) by targeting cyclin D3 (CCND3)...
  66. doi A natural HIV p17 protein variant up-regulates the LMP-1 EBV oncoprotein and promotes the growth of EBV-infected B-lymphocytes: implications for EBV-driven lymphomagenesis in the HIV setting
    Debora Martorelli
    Cancer Bio Immunotherapy Unit, CRO Aviano, IRCCS, National Cancer Institute, Aviano, Pordenone, Italy
    Int J Cancer 137:1374-85. 2015
    ....
  67. doi Differential Expression of Cell Cycle Regulators During Hyperplastic and Hypertrophic Growth of Broiler Subcutaneous Adipose Tissue
    J Zhang
    Department of Animal Sciences, The Ohio State University, Columbus, OH, 43210, USA
    Lipids 50:965-76. 2015
    ..This study provides further understanding about broiler fat tissue development which is imperative for effective control of fat deposition. ..
  68. doi Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
    Canan Eroğlu
    Department of Medical Biology, Faculty of Meram Medicine, Konya Necmettin Erbakan University, Konya, Turkey
    Tumour Biol 36:9437-46. 2015
    ..Moreover, it suppressed the colony formation. In conclusion, it has been observed that FA may lead to cell cycle arrest in PC-3 cells while it may cause apoptosis in LNCaP cells...
  69. doi The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma
    Rabea Wagener
    Institute of Human Genetics, Christian Albrechts University Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Genes Chromosomes Cancer 54:555-64. 2015
    ..We conclude that PCBP1 mutations are recurrent in Burkitt lymphomas and might contribute, in cooperation with other mutations, to its pathogenesis...
  70. doi MicroRNA-138 negatively regulates non-small cell lung cancer cells through the interaction with cyclin D3
    Li Ping Han
    Department of Respiratory Medicine, Jining First People s Hospital, 6 Jiankang Road, Jining, 272000, China
    Tumour Biol 37:291-8. 2016
    ..A new miR-138 downstream target, cyclin D3 (CCND3), was assessed by dual-luciferase reporter assay and quantitative real-time PCR (qRT-PCR)...
  71. pmc CDK4 is an essential insulin effector in adipocytes
    Sylviane Lagarrigue
    J Clin Invest 126:335-48. 2016
    ..Furthermore, we found that CCND3 expression and IRS2 serine 388 phosphorylation are increased in human obese subjects. Together, our results demonstrate that CDK4 is a major regulator of insulin signaling in WAT...
  72. doi Genetic differences between paediatric and adult Burkitt lymphomas
    Violaine Havelange
    Department of Haematology, Cliniques Universitaires Saint Luc Université Catholique de Louvain, Brussels, Belgium
    Br J Haematol 173:137-44. 2016
    ..This may explain the poorer prognosis of adult BLs. Additional studies are needed to confirm these results in the setting of clinical trials. ..
  73. doi Molecular cues to the anti-implantation effect of nano-puerarin in rats
    Ghungroo Saraswat
    Reproductive Biology ResearchCSIR Indian Institute of Chemical Biology, Jadavpur, Kolkata, West Bengal, India
    Reproduction 151:693-707. 2016
    ..that PN enforced inhibition of uterine expression of Hbegf and Hoxa10 and their downstream signalling molecules, Cyclin D3 (CCND3)/CDK4...
  74. doi Cell-Cycle Gene Alterations in 4,864 Tumors Analyzed by Next-Generation Sequencing: Implications for Targeted Therapeutics
    Teresa Helsten
    Center for Personalized Cancer Therapy, UC San Diego Moores Cancer Center, La Jolla, California
    Mol Cancer Ther 15:1682-90. 2016
    ..The frequencies and types of alterations differed between and within tumor types and will be informative for drug development strategies. Mol Cancer Ther; 15(7); 1682-90. ©2016 AACR. ..
  75. doi Myeloma Drug Resistance Induced by Binding of Myeloma B7-H1 (PD-L1) to PD-1
    Mariko Ishibashi
    Division of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan
    Cancer Immunol Res 4:779-88. 2016
    ..These observations provide mechanistic insights into potential immunotherapeutic benefits of blocking the B7-H1-PD-1 pathway. Cancer Immunol Res; 4(9); 779-88. ©2016 AACR. ..
  76. pmc Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice
    Dang Dang Li
    a College of Veterinary Medicine, Jilin University, Changchun, P R China
    Cell Cycle 15:2792-805. 2016
    ..In the stromal cells undergoing decidualization, Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. Collectively, Hmgn5 may play an important role during mouse decidualization. ..
  77. ncbi Gene expression profiles defining molecular subtypes, coupled with signatures of tumor biology and chemotherapy sensitivity provide a novel therapuetic approach to multiple myeloma
    A Anguiano
    Duke University Medical Center, Durham, NC University of Arkansas for Medical Sciences, Little Rock, AR
    J Clin Oncol 26:8501. 2008
    ..Genomic evidence of chemotherapy sensitivity and oncogenic pathway activation may provide an opportunity for selection of therapeutic modalities. No significant financial relationships to disclose...
  78. ncbi Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma
    Bo Bin Chen
    Department of Hematology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China
    Chin Med J (Engl) 126:482-7. 2013
    ..Clinical outcome in patients with primary central nervous lymphoma (PCNSL) is variable and poorly predictable. This study investigated the association of clinical features and immune markers with prognosis of patients with PCNSL...
  79. pmc Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis
    Kezhen Yang
    Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, 20 Nanxincun, Beijing 100093, China
    J Exp Bot 65:2449-61. 2014
    ..However, timely down-regulation of CDKA;1-CYCD3 activity is required for restriction of GC proliferation. ..
  80. pmc Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics
    Roland Schmitz
    Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 490:116-20. 2012
    ..In 38% of sporadic BL cases, oncogenic CCND3 mutations produced highly stable cyclin D3 isoforms that drive cell cycle progression...
  81. pmc Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
    J Vlach
    Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
    EMBO J 15:6595-604. 1996
    ..We propose that this activity is mediated by the product of an as yet unknown Myc-Max target gene(s) and represents an essential aspect of Myc's mitogenic and oncogenic functions...
  82. ncbi Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content
    N S Datta
    Department of Pediatrics, University of Michigan, Ann Arbor 48109, USA
    Cell Growth Differ 9:639-50. 1998
    ....
  83. ncbi Detection of amplification of a chromosomal fragment at 6p21 including the cyclin D3 gene in a glioblastoma cell line by arbitrarily primed polymerase chain reaction
    H Kuchiki
    Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 85:113-6. 2000
    ..The cyclin D3 (ccnd3) gene and an EST locus, H40682, both of which were located in this region, were amplified by about 50-..
  84. ncbi Comprehensive analysis of genomic alterations in gliosarcoma and its two tissue components
    Bertrand Actor
    Abteilung Molekulare Genetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Genes Chromosomes Cancer 34:416-27. 2002
    ..According to our data, gain/amplification of genes on proximal 12q may facilitate the development of a sarcomatous phenotype...
  85. ncbi Acute and chronic effect of dietary phosphorus restriction on protein expression in young rat renal proximal tubules
    Pik Yuen Cheung
    The Open Laboratory of Chirotechnology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong PRC
    Proteomics 2:1211-9. 2002
    ..Our results showed that beta-actin, gamma-actin, major urinary protein, phosphatidylinositol transfer protein beta isoform, and G1/S-specific cyclin D3 are up-regulated and nonspecific lipid transfer protein is down-regulated by LPD.
  86. ncbi Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR
    T Sonoki
    Academic Haematology and Cytogenetics, Institute of Cancer Research, UK
    Leukemia 18:2026-31. 2004
    ..The combination of LDI-PCR for IGHJ and IGHS allows rapid molecular cloning of almost all IGH gene translocation breakpoints...
  87. ncbi Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis
    Hideaki Tanami
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Lab Invest 85:1118-29. 2005
    ..0152). In addition, immunohistochemical analysis of 120 primary CRC tumors demonstrated that cyclin D3 expression in the region of rolled edge was significantly associated with total recurrence, especially ..
  88. pmc The molecular classification of multiple myeloma
    Fenghuang Zhan
    Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Blood 108:2020-8. 2006
    ..A subset of cases with a predominating myeloid gene expression signature, excluded from the profiling analyses, had more favorable baseline characteristics and superior prognosis to those lacking this signature...
  89. pmc Comparison of functional proteomic analyses of human breast cancer cell lines T47D and MCF7
    Juliette Adjo Aka
    Laboratory of Endocrinology and Genomics, CHUL Research Center CHUQ, Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e31532. 2012
    ..A list of differentially expressed proteins between T47D and MCF7 was generated, providing useful information for further studies of breast cancer mechanisms with these cell lines as models...
  90. doi Immunohistochemical expression of cell-cycle regulators in pediatric embryonal brain tumors
    Maria Moschovi
    Hematology Oncology Unit, 1st Department of Pediatrics, Athens University, Athens, Greece
    J Neurooncol 109:529-34. 2012
    ..Thus, the purpose of this study was to investigate the expression of p-27, Cyclin D3, and Cyclin E, and their possible prognostic significance in pediatric embryonal brain tumors...
  91. pmc Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia
    Catherine M Sawai
    Department of Pathology and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Cancer Cell 22:452-65. 2012
    ..Although cyclin D functions appear largely tissue specific, we demonstrate that cyclin D3 has unique functions in lymphocyte development and cannot be replaced by cyclin D2, which is also expressed ..
  92. pmc Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas
    Jin Young Lee
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Gwanak Gu, Seoul, Korea
    PLoS ONE 7:e51592. 2012
    ....
  93. pmc CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma
    Itziar Salaverria
    Department of Pathology, Hematopathology Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Blood 121:1394-402. 2013
    ....
  94. ncbi Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene
    T Motokura
    Endocrine Unit, Massachusetts General Hospital, Boston 02114
    J Biol Chem 267:20412-5. 1992
    ..We have cloned a related human cDNA, called cyclin D3, from a placental cDNA library by cross-hybridization with PRAD1...
  95. ncbi Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Genomics 13:575-84. 1992
    ..We now report the molecular cloning of two additional human D-type cyclin genes, CCND2 (cyclin D2) and CCND3 (cyclin D3)...
  96. ncbi D-type cyclin-binding regions of proliferating cell nuclear antigen
    S Matsuoka
    Laboratory of Cell Biology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Biol Chem 269:11030-6. 1994
    ..This is apparently the first report on the structure-function relationship of PCNA which may link DNA replication and DNA repair with cell cycle control...
  97. ncbi Physical interaction of the retinoblastoma protein with human D cyclins
    S F Dowdy
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Cell 73:499-511. 1993
    ..We conclude that cyclins D1 and D3 interact with pRb in a fashion distinct from cyclins A and E, which can induce pRb hyperphosphorylation, and that cyclin D1 activity may be regulated by its association with pRb...
  98. pmc Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest
    N Tiefenbrun
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 16:3934-44. 1996
    ..Within a few hours after alpha-interferon treatment, cyclin D3 mRNA and protein levels dropped to undetectable levels and, in parallel, the activities of cyclin A- and cyclin ..
  99. ncbi Antiproliferative function of p27kip1 is frequently inhibited in highly malignant Burkitt's lymphoma cells
    K Barnouin
    Ludwig Institute for Cancer Research, Imperial College School of Medicine at St Mary s, London, UK
    Oncogene 18:6388-97. 1999
    ..Interestingly, we observed that high level p27kip1 expression often correlated with cyclin D3 overexpression both in vivo and in BL cell lines...
  100. ncbi Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors
    J R Fink
    Department of Laboratory Medicine Pathology, University of Minnesota Cancer Center, 420 Delaware Street S E, Minneapolis, MN 55455, USA
    Exp Hematol 29:490-8. 2001
    ..RT-PCR analysis showed that cyclin D2, cyclin D3, CDK4, and CDK6 were ubiquitously expressed in normal B-cell development and in the BLIN ALL cell lines...
  101. ncbi In vitro ubiquitination of cyclin D1 by ROC1-CUL1 and ROC1-CUL3
    I Maeda
    Department of Surgery, St Marianna University School of Medicine, 2 16 1 Sugao, Niyamae ku, Kawasaki 216 8511, Japan
    FEBS Lett 494:181-5. 2001
    ..The results suggest the involvement of ROC1-cullin ligases in cyclin D1 ubiquitination and a potential mechanism whereby the cullin subunit is ubiquitinated itself while ubiquitinating a substrate...

Research Grants3

  1. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..In previous studies, we demonstrated that cyclin D3 is uniquely required for clonal expansion of pre-B cells (Nat Immunol 7:489)...
  2. Molecular Pathogenesis of Multiple Myeloma
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..abstract_text> ..
  3. GENETIC LINKAGE IN COLORECTAL CANCER FAMILES
    Ellen Goode; Fiscal Year: 2008
    ..A key future aim is to combine these families with those of other CRC linkage studies in the US and UK to amass an extensive resource with further increased power to understand CRC genetic susceptibility. ..