Genomes and Genes
Gene Symbol: cyclin B1
Description: cyclin B1
Alias: CCNB, G2/mitotic-specific cyclin-B1
Publications192 found, 100 shown here
- High cyclin B1 expression is associated with poor survival in breast cancerK Aaltonen
Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
Br J Cancer 100:1055-60. 2009b>Cyclin B1 regulates the G(2)-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions...
- Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrestAime A Levesque
Department of Pharmacology and Toxicology and Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH 03756, USA
Mol Cancer Ther 7:252-62. 2008....
- Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastropheY W Chan
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong
Oncogene 28:170-83. 2009..We found that although cyclin B1 was required for mitotic catastrophe, it was cleaved into a approximately 35 kDa protein by a caspase-dependent ..
- Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transitionOleg Timofeev
Cell Cycle Control and Carcinogenesis, German Cancer Research Center, F045, Im Neuenheimer Feld 242, D 69120 Heidelberg, Germany
J Biol Chem 285:16978-90. 2010..In conclusion, our data suggest that complex assembly and dephosphorylation of Cdk1 at G(2)/M is tightly coupled and regulated by Cdc25 phosphatases...
- G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differentlyP M O'Connor
Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:8298-308. 1993..HN2-induced a protracted delay in G2 phase. This delay correlated with suppression of cyclin B1- and cdc2-kinase activities, and stabilization of hyperphosphorylated-cdc2 in the presence of similar cyclin B1 ..
- Alteration of subcellular and cellular expression patterns of cyclin B1 in renal cell carcinoma is significantly related to clinical progression and survival of patientsStephen O Ikuerowo
Department of Urology, Medizinische Hochschule Hannover, Hannover, Germany
Int J Cancer 119:867-74. 2006b>Cyclin B1, identified as a regulator of late cell cycle, is involved in the development and progression of a variety of human malignancies...
- UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complexTao Wu
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:1355-60. 2010..UBE2S copurifies with APC; dominant-negative Ube2S slows down APC substrate degradation in functional cell-cycle extracts. We propose that Ube2S is a critical, unique component of the APC ubiquitination pathway...
- Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phaseLingyun Li
Department of Microbiology and Immunology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
J Virol 85:6774-83. 2011..We then showed that the activity of the Cdc2-cyclin B1 complex was significantly decreased in HHV-6A-infected HSB-2 cells...
- Mip/LIN-9 regulates the expression of B-Myb and the induction of cyclin A, cyclin B, and CDK1Mark Pilkinton
Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 282:168-75. 2007..These data support the concept that Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and mitotic cyclins...
- Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinaseL L Parker
Department of Physiology, Tufts University School of Medicine, Boston, MA 02111
Science 257:1955-7. 1992..These results indicate that the product of the WEE1Hu gene directly regulates the p34cdc2-cyclin B complex in human cells and that a kinase other than that encoded by WEE1Hu phosphorylates p34cdc2 on threonine 14...
- Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin BF Re
Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Virol 69:6859-64. 1995..These studies demonstrate that HIV-1 vpr has profound effects on the cellular factors which control entry into mitosis and indicate vpr's potential contribution to the cellular pathology associated with HIV-1 infection...
- Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatusM Jackman
Wellcome CRC Institute, Cambridge, UK
EMBO J 14:1646-54. 1995..b>Cyclin B1 and B2 levels are very low in G1 phase, increase in S and G2 phases and peak at mitosis...
- HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activatorL K Felzien
Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
Proc Natl Acad Sci U S A 95:5281-6. 1998..Vpr causes arrest of cell cycle progression at G2/M, presumably through its effect on cyclin B1.Cdc2 activity...
- Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1J Yang
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
Genes Dev 12:2131-43. 1998Activation of the Cyclin B/Cdc2 kinase complex triggers entry into mitosis in all eukaryotic cells. Cyclin B1 localization changes dramatically during the cell cycle, precipitously transiting from the cytoplasm to the nucleus at the ..
- Mitotic regulation of the APC activator proteins CDC20 and CDH1E R Kramer
Research Institute of Molecular Pathology, A 1030 Vienna, Austria
Mol Biol Cell 11:1555-69. 2000..These mechanisms can explain the temporal order of APC activation by CDC20 and CDH1 and may help to ensure that exit from mitosis is not initiated before anaphase has occurred...
- Active cyclin B1-Cdk1 first appears on centrosomes in prophaseMark Jackman
Wellcome Trust Cancer Research UK Institute and Department of Zoology, Tennis Court Road, Cambridge, CB2 1QR, UK
Nat Cell Biol 5:143-8. 2003b>Cyclin B1-Cdk1 is the key initiator of mitosis, but when and where activation occurs has not been precisely determined in mammalian cells...
- A direct role for GRASP65 as a mitotically regulated Golgi stacking factorYanzhuang Wang
Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
EMBO J 22:3279-90. 2003..These can be disaggregated using purified cdc2-cyclin B1 and polo-like kinases, and re-aggregated after dephosphorylation of GRASP65...
- Degradation of cyclin B is required for the onset of anaphase in Mammalian cellsDonald C Chang
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Biol Chem 278:37865-73. 2003Recently, it has been shown that cyclin B1 was degraded mainly before the onset of anaphase in mammalian cells. When a nondegradable form of cyclin B1 was introduced into cells, the metaphase-anaphase transition was blocked...
- FoxM1 is required for execution of the mitotic programme and chromosome stabilityJamila Laoukili
Division of Molecular Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Nat Cell Biol 7:126-36. 2005..Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression...
- Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topologyDonald S Kirkpatrick
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Nat Cell Biol 8:700-10. 2006..Here, we used a reconstituted system and quantitative mass spectrometry to demonstrate that cyclin B1 is modified by ubiquitin chains of complex topology, rather than by homogeneous Lys 48-linked chains...
- Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exitVincenzo D'Angiolella
Faculty of Biotechnological Sciences and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, University of Napoli Federico II, Italy
PLoS ONE 2:e247. 2007..By sampling extracts at very short intervals during both meiotic and mitotic exit, we found that cyclin B1-associated cdk1 underwent transient inhibitory phosphorylation at tyr-15 and that cyclin B1-cdk1 activity fell ..
- Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosisAnna M Bentley
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Biol Cell 18:4847-58. 2007..During mitosis, cyclin B1 is known to localize to centrosomes, microtubules, and chromatin...
- High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosisLi Tang
Department of Reproductive Endocrinology, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
Fertil Steril 91:979-87. 2009To investigate the possible roles of cyclin B1/cyclin-dependent kinase (cdc2) and Polo-like kinase 1 (Plk1) in the pathogenesis of endometriosis.
- UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exitMathew J Garnett
University of Cambridge, Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge, CB2 OXZ, UK
Nat Cell Biol 11:1363-9. 2009..Thus, UBE2S functions with the APC/C in a two-step mechanism to control substrate ubiquitylation that is essential for mitotic exit after prolonged SAC activation, providing a new model for APC/C function in human cells...
- Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosomeE Bailly
Centre de Genetique Moleculaire CNRS, Gif sur Yvette, France
J Cell Sci 101:529-45. 1992..We show here that part of cyclin B1 is associated with duplicating centrosomes throughout its accumulation in the cytoplasm and up to metaphase...
- Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transportJ Pines
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186 5800
J Cell Biol 115:1-17. 1991..By contrast, cyclin B1 accumulates in the cytoplasm of interphase cells and only enters the nucleus at the beginning of mitosis, before ..
- Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 proteinU Strausfeld
CNRS and INSERM, BP 5051, Montpellier, France
Nature 351:242-5. 1991..We propose that the cdc25+ gene product directly activates the p34cdc2-cyclin B complex...
- Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2J Pines
Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, San Diego, California 92138
Cell 58:833-46. 1989..In G2/M phase, cyclin is associated with p34cdc2, the human homolog of the fission yeast gene cdc2+, and this complex has histone H1 kinase activity...
- Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activityJ He
Aaron Diamond AIDS Research Center, New York, New York 10016, USA
J Virol 69:6705-11. 1995..In vivo, Vpr might, by preventing p34cdc2 activation, delay or prevent apoptosis of infected cells. This would increase the amount of virus each infected cell produced...
- Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprP Di Marzio
Aaron Diamond AIDS Research Center, New York, New York, USA
J Virol 69:7909-16. 1995..We speculate that Vpr has two sites for interaction with cellular factors: one in the alpha-helical region that specifies nuclear localization and one in the carboxy-terminal domain that is required for Cdc2 inhibition...
- The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleJ B Jowett
Department of Microbiology and Immunology, UCLA School of Medicine 90095 1678, USA
J Virol 69:6304-13. 1995..Cell cycle arrest induced by Vpr correlates with an increase in the hyperphosphorylated (inactive) form of the cyclin-dependent serine/threonine kinase CDC2, consistent with an arrest of cells at the boundary of G2 and M...
- The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin BJ Pines
Wellcome CRC Institute, Cambridge, UK
EMBO J 13:3772-81. 1994..that human cyclins A and B1 are localized differentially in the cell during interphase; cyclin A is nuclear and cyclin B1 is a cytoplasmic protein...
- The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complexF Liu
Department of Cell Biology and Physiology, Washington University Medical School, St Louis, Missouri 63110 1093, USA
Mol Cell Biol 17:571-83. 1997..A stretch of hydrophobic and uncharged amino acids located outside the catalytic domain of Myt1Hu is the likely membrane-targeting domain, as its deletion results in the localization of Myt1Hu primarily to the nucleus...
- The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteinsM Shen
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Division on Aging, Harvard Medical School, Boston, Massachusetts 02215 USA
Genes Dev 12:706-20. 1998..Thus, Pin1 likely acts as a general regulator of mitotic proteins that have been phosphorylated by Cdc2 and other mitotic kinases...
- T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21T Ohta
First Department of Surgery, St Marianna University School of Medicine, Kawasaki, Japan
Cancer Res 58:1095-8. 1998..CDC2deltaT protein is unable to complex with cyclin B1 and lacks histone H1 kinase activity. CDC2deltaT also fails to bind to the CDK inhibitor p21...
- Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45Q Zhan
Laboratory of Biological Chemistry, Division of Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Oncogene 18:2892-900. 1999..While inhibitory phosphorylation of Cdc2 and suppression of cyclin B1 levels are known to be involved in G2 delays after genotoxic stress, Gadd45 has now been found to directly ..
- Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexesF Liu
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
Mol Cell Biol 19:5113-23. 1999..Throughout interphase, human Myt1 localizes to the endoplasmic reticulum and Golgi complex, whereas Cdc2-cyclin B1 complexes shuttle between the nucleus and the cytoplasm...
- Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signalA Hagting
Wellcome CRC Institute, Department of Zoology, Tennis Court Road, Cambridge, CB2 1QR, UK
Curr Biol 9:680-9. 1999At M phase, cyclin B1 is phosphorylated in the cytoplasmic retention sequence (CRS), which is required for nuclear export...
- Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpointY Yudkovsky
Unit of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel
Biochem Biophys Res Commun 271:299-304. 2000..It is suggested that inhibitory phosphorylation of Cdc20/Fizzy may have a role in keeping the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest...
- A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phaseA Nishiyama
Laboratory of Cell and Developmental Biology, Graduate School of Biosciences, Tokyo Institute of Technology, Midori ku, Yokohama 226 8501, Japan
Genes Dev 14:2344-57. 2000..As a result, cyclin B levels decrease on exit from M phase but Cdc2 levels remain constant...
- Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophaseF Toyoshima-Morimoto
Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
Nature 410:215-20. 2001In vertebrate cells, the nuclear entry of Cdc2-cyclin B1 (MPF) during prophase is thought to be essential for the induction and coordination of M-phase events...
- Effector genes altered in MCF-7 human breast cancer cells after exposure to fractionated ionizing radiationZ Li
Department of Radiation Research, Beckman Research Institute, City of Hope National Medical Center, 1500 Duarte Road, Duarte, CA 91010, USA
Radiat Res 155:543-53. 2001....
- Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complexC M Pfleger
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 15:2396-407. 2001..Thus, Cdc20 and Cdh1 act as both substrate recognition and activating modules for APC...
- Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14aJ Bembenek
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
J Biol Chem 276:48237-42. 2001..hCdc14a is a major phosphatase for hCdh1 and localizes to centrosomes in HeLa cells. Therefore, hCdc14a may promote the activation of APC(Cdh1) and exit from mitosis in mammalian cells...
- Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteinsJ D Reimann
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
Genes Dev 15:3278-85. 2001..We find that Emi1 binds the substrate-binding region of Cdc20 and prevents substrate binding to the APC, illustrating a novel mechanism of APC inhibition...
- Prognostic value of cyclin B1 in patients with esophageal squamous cell carcinomaShinsuke Takeno
Departments of Surgery II, Oita Medical University, Hasama machi, Oita, Japan
Cancer 94:2874-81. 2002It has been reported that p53 regulates the G2-M checkpoint transition through cyclin B1, and it has been suggested that p53 plays an important role in the development and progression of various malignancies...
- Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1Juping Yuan
Department of Obstetrics and Gynecology, JW Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt, Germany
Oncogene 21:8282-92. 2002The cyclin-dependent kinase 1 (Cdc2)/cyclin B1 complex performs cardinal roles for eukaryotic mitotic progression...
- TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1Hartmut C Vodermaier
Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030, Vienna, Austria
Curr Biol 13:1459-68. 2003..The APC is a ubiquitin ligase composed of at least 11 subunits. The interaction of APC2 and APC11 with E2 enzymes is sufficient for ubiquitination reactions, but the functions of most other subunits are unknown...
- Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirusVeronica Sanchez
Molecular Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0366, USA
J Virol 77:13214-24. 2003..the induction of this kinase activity, we have examined the pathways that regulate the activation of Cdk1/cyclin B1 complexes...
- The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancerT Yoshida
Department of Surgery I, Gunma University Faculty of Medicine, Maebashi, Gunma, Japan
Ann Oncol 15:252-6. 2004b>Cyclin B1 has an important role in the G2-M phase transition of the cell cycle. Wee1 delays mitosis by suppressing the activity of the Cyclin B1/cdc2 complex...
- Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivatorsMichael L Major
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 24:2649-61. 2004....
- p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcriptionSteven A Innocente
Hamilton Regional Cancer Centre, Hamilton, Ont, Canada
FEBS Lett 579:1001-7. 2005..We have previously reported that p53 prevents G2/M transition by decreasing intracellular levels of cyclin B1 protein and attenuating the activity of the cyclin B1 promoter [S.A. Innocente, J.L. Abrahamson, J.P...
- The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substratesClaudine Kraft
Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Mol Cell 18:543-53. 2005..Our data imply that APC/C is activated by the association of Cdh1 with Cdc27, which enables APC/C to recognize the D box of substrates via Cdh1's propeller domain...
- Mutual inhibition of separase and Cdk1 by two-step complex formationIngo H Gorr
Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
Mol Cell 19:135-41. 2005..In a second step, Cdk1 stably binds phosphorylated separase via its regulatory cyclin B1 subunit...
- Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1H R Seo
Laboratory of Radiation Effect, Korea Institute of Radiological and Medical Sciences, 215 4 Gongneung dong, Nowon Ku, Seoul 139 706, Korea
Cell Death Differ 13:1475-84. 2006..report hitherto unknown mechanism by which cyclin G1 increases radiation sensitivity by regulating the level of cyclin B1. Overexpression of cyclin G1 was observable in lung carcinoma tissues...
- Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorJulie J Miller
Program in Molecular Pharmacology, Stanford University School of Medicine, Stanford, California 94305, USA
Genes Dev 20:2410-20. 2006..The combination of a degron/E3 recognition site and an anti-ligase function in Emi1 suggests a general model for how E3 substrates evolve to become pseudosubstrate inhibitors...
- Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factorTakashi Suzuki
Department of Pathology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Miyagi ken, 980 8575, Japan
Cancer Sci 98:644-51. 2007b>Cyclin B1 is translocated to the nucleus from the cytoplasm, and plays an essential role in cell proliferation through promotion of mitosis...
- Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cellsStephane Larochelle
Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Mol Cell 25:839-50. 2007..Therefore, by combining chemical genetics and homologous gene replacement in somatic cells, we reveal different modes of CDK activation by Cdk7 at two distinct execution points in the cell cycle...
- Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosisLindsey A Allan
Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Mol Cell 26:301-10. 2007..This site is phosphorylated by CDK1/cyclin B1 during mitosis and in response to microtubule poisons that arrest cells at this stage of the cell cycle...
- Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progressionArne Lindqvist
Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
PLoS Biol 5:e123. 2007Activation of cyclin B1-cyclin-dependent kinase 1 (Cdk1), triggered by a positive feedback loop at the end of G2, is the key event that initiates mitotic entry...
- Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2S Bellanger
Laboratoire de Biochimie Cellulaire, CNRS UMR 7098, Université P and M Curie Paris 6, Paris, France
Oncogene 26:7175-84. 2007..of these cyclins in CDK1 activation, but cyclin B2 is thought to play a minor role and to be unable to replace cyclin B1 for mitosis completion...
- Different thresholds of MPF inactivation are responsible for controlling different mitotic events in mammalian cell divisionNaihan Xu
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Cell Cycle 6:1639-45. 2007..The key temporal control here is the degradation of cyclin B1. Using single cell analysis, we measured the kinetics of cyclin B1 degradation and determined quantitatively the ..
- Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasisYongmei Song
State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Carcinogenesis 29:307-15. 2008b>Cyclin B1, a key component in the control of cell cycle progression from G(2) to M phase, has been implicated in tumorigenesis and the development of malignancy...
- Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosisQiang Chen
The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Bio engineering, College of Life Sciences, Peking University, Beijing 100871, China
Cell Res 18:268-80. 2008b>Cyclin B1 is a key regulatory protein controlling cell cycle progression in vertebrates...
- cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent mannerEwan M Smith
Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, UK
EMBO J 27:1005-16. 2008..These data closely match the control of Ser359 phosphorylation and indicate that cdc2 may be regulated by mTORC1...
- Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic eventsL de Boer
Cancer Biology Program, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Oncogene 27:4261-8. 2008....
- 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 VprDiane L Bolton
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD 20892, USA
Biol Direct 3:17. 2008..The HIV-1 Vpr accessory protein causes cell death, likely through a mechanism related to its ability to arrest cells in the G2,M phase. Recent evidence implicated the scaffold protein, 14-3-3, in Vpr cell cycle blockade...
- Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin ARob Wolthuis
Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
Mol Cell 30:290-302. 2008..Central to this is the spindle checkpoint that prevents the destruction of securin and cyclin B1 when there are improperly attached chromosomes...
- Evaluation of cell cycle protein expression in gastric cancer: cyclin B1 expression and its prognostic implicationMaria D Begnami
Department of Pathology, Hospital AC Camargo, 01509900 São Paulo, Brazil
Hum Pathol 41:1120-7. 2010..Diffuse carcinomas frequently were positive for cyclin B1 and pRb, and negative for p21. A relationship between p53 expression and intestinal type carcinomas was found...
- Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosisOlivier Gavet
The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, England, UK
J Cell Biol 189:247-59. 2010..What triggers the nuclear accumulation of cyclin B1 is presently unclear, although the prevailing view is that the Plk1 kinase inhibits its nuclear export...
- Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosisOlivier Gavet
The Gurdon Institute and Department of Zoology, Tennis Court Road, CB2 1QN Cambridge, UK
Dev Cell 18:533-43. 2010....
- Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrestMargaret E Harley
Biomedical Research Institute, School of Medicine, College of Medicine, Dentistry and Nursing, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK
EMBO J 29:2407-20. 2010..Phosphorylation of Thr92 by cyclin-dependent kinase 1 (CDK1)-cyclin B1 initiates degradation of Mcl-1 in cells arrested in mitosis by microtubule poisons...
- The roles of cyclin A2, B1, and B2 in early and late mitotic eventsDelquin Gong
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
Mol Biol Cell 21:3149-61. 2010..Cyclin A2 is required for the activation and nuclear accumulation of cyclin B1-Cdk1, raising the possibility that cyclin B1-Cdk1 mediates the effects of cyclin A2...
- The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitWouter van Zon
Division of Molecular Biology and 2 Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, Netherlands
J Cell Biol 190:587-602. 2010..This initiates cyclin A degradation, whereas cyclin B1 is stabilized by the spindle checkpoint...
- Cell cycle-dependent regulation of the forkhead transcription factor FOXK2 by CDK·cyclin complexesAnett Marais
Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
J Biol Chem 285:35728-39. 2010..These two CDK sites appear vital for FOXK2 function because expression of a mutant lacking these sites cannot be tolerated and causes apoptosis...
- Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannerMin Sup Song
Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Cell 144:187-99. 2011..This finding identifies a strategy for cancer patient stratification and, thus, optimization of targeted therapies. PAPERCLIP:..
- Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implicationsSeoung Wan Chae
Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Jongno gu, Seoul 110 746, Korea
Yonsei Med J 52:445-53. 2011The molecular mechanisms that are responsible for the initiation and progression of breast cancers are largely unknown. This study was to analyze the cyclin B1, cdc2, p53 and p16 tumor suppressor genes in human breast cancer.
- Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entryXiaodong Huang
Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Mol Cell 42:511-23. 2011..USP37 was inactive in mitosis because it was no longer phosphorylated by CDK2. Indeed, it switched from an antagonist to a substrate of APC(CDH1) and was modified with degradative K11-linked polyubiquitin...
- Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neckThomas K Hoffmann
Department of Otorhinolaryngology, University of Duisburg Essen, Hufelandstrasse 55, 45147 Essen, Germany
Anticancer Res 31:3151-7. 2011The cyclin B1/CDC2 complex governs entry into mitosis by regulating the G(2)/M checkpoint, and it can be repressed by the tumor suppressor p53...
- APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1Nevena V Dimova
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Cell Biol 14:168-76. 2012..complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin...
- Spatial positive feedback at the onset of mitosisSilvia D M Santos
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
Cell 149:1500-13. 2012Mitosis is triggered by the activation of Cdk1-cyclin B1 and its translocation from the cytoplasm to the nucleus...
- APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complexKristina Uzunova
Research Institute of Molecular Pathology, Vienna, Austria
Nat Struct Mol Biol 19:1116-23. 2012..We propose that APC15 and Mnd2 negatively regulate APC/C coactivators and report generation of recombinant human APC/C...
- Structural analysis of human Cdc20 supports multisite degron recognition by APC/CWei Tian
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 109:18419-24. 2012..complex/cyclosome (APC/C) promotes anaphase onset and mitotic exit through ubiquitinating securin and cyclin B1. The mitotic APC/C activator, the cell division cycle 20 (Cdc20) protein, directly interacts with APC/C degrons--..
- Cyclin B1 is rate limiting but not essential for mitotic entry and progression in mammalian somatic cellsDeena V Soni
Environmental Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA
Cell Cycle 7:1285-300. 2008b>Cyclin B1 should have some rate limiting function for cell cycle progression. To test this, we measured the effect of siRNA-mediated depletion of cyclin B1 on mitotic entry and timing...
- Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancerRoshan Agarwal
The University of Texas M D Anderson Cancer Center MDACC, Houston, Texas, USA
Clin Cancer Res 15:3654-62. 2009..We studied the expression levels of cyclins B1, D1, and E1 and the implications of cyclin overexpression for patient outcomes in distinct breast cancer subtypes defined by clinical variables and transcriptional profiling...
- Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interactionM Kong
Department of Chemistry, Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0367, USA
EMBO J 19:1378-88. 2000..b>Cyclin B1 nuclear localization involves phosphorylation within a region called the cytoplasmic retention signal, which ..
- A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levelsGarabet G Toby
Division of Basic Science, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
Mol Cell Biol 23:2109-22. 2003..Through two-hybrid screening, the mitotic cyclin B1 and an E2 ubiquitin-conjugating enzyme were isolated as HEI10-interacting proteins...
- Porcine SPDYA2 (RINGO A2) stimulates CDC2 activity and accelerates meiotic maturation of porcine oocytesSachi Kume
Department of Animal Resource Sciences, Graduate School of Agricultural Sciences, University of Tokyo, Tokyo 113 8657, Japan
Biol Reprod 76:440-7. 2007..The CCNB (also known as cyclin B) synthesis was prematurely started at 12 h of culture, whereas it started at 18 h in normal ..
- Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinomaDemetrius M Kokkinakis
Department of Pathology, University of Pittsburgh, PA 15213 1863, USA
Mol Cancer Ther 4:1338-48. 2005..of NF2, ETS2, CLU, GADD45alpha, GADD45beta, and GADD45gamma and down-regulation of AURKB, TOP2A, CCNA, CCNB, PRC1, BUB1, NuSAP, IFI16, and BRCA1...
- Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycleYing Nan Yu
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, MD10, S 117 597 Singapore
Int J Oncol 37:483-92. 2010..The data obtained from the tissue microarrays and cell lines provide evidence that YB-1 is a reliable marker of cell proliferation and possibly a potential molecular target in breast cancer therapy...
- Three independent mechanisms for arrest in G2 after ionizing radiationKirsti Solberg Landsverk
Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
Cell Cycle 10:819-29. 2011..In conclusion, the IR-induced arrest in G(2) is mediated by ATM immediately after irradiation, with TP53 for independent and transient back-up, while CHEK1 is necessary for the late arrest...
- The Tg(ccnb1:EGFP) transgenic zebrafish line labels proliferating cells during retinal development and regenerationSean C Kassen
Department of Biological Sciences and Center for Zebrafish Research, University of Notre Dame, Notre Dame, IN 46556, USA
Mol Vis 14:951-63. 2008..To create the Tg(ccnb1:EGFP)(nt18) zebrafish line that spatially and temporally labels retinal progenitor cells with enhanced green fluorescent protein (EGFP) during zebrafish retinal development and regeneration...
- Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinomaHuichen Feng
Department of Anatomy, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China
Gynecol Oncol 94:375-82. 2004..To assess the differential gene expression in neoplastic and normal trophoblastic cells and evaluate the effect of methylation on tissue inhibitor of metalloproteinase 3 (TIMP3) expression in choriocarcinoma (CCA) cells...
- The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5J M Scharf
Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Genomics 38:405-17. 1996..Mutations in such a gene might help to explain some of the phenotypic variability among the human SMAs...
- Expression profiling of tetraploid mouse embryos in the developmental stages using a cDNA microarray analysisJutaro Kawaguchi
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Science, University of Tokyo, Tokyo, Japan
J Reprod Dev 55:670-5. 2009..Among these downregulated genes, Ccnb1 (cyclin B1), which was decreased by 3-fold, seemed to play a particularly important role in the cellular organization of ..
- Prognostic factors in prolactin pituitary tumors: clinical, histological, and molecular data from a series of 94 patients with a long postoperative follow-upGerald Raverot
Institut National de la Sante et de la Recherche Medicale, Unité 842, Universite de Lyon, Lyon 1, Unité Mixte de Recherche UMR S842, Faculté de médecine Lyon Est, F 69372 Lyon, Cedex 08, France
J Clin Endocrinol Metab 95:1708-16. 2010..Predicting pituitary tumor behavior remains a challenge. This multiparameter investigation aimed to identify markers for recurrence and progression in prolactin tumors...
- Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targetsOluf Dimitri Røe
Department of Oncology, St Olavs Hospital, Trondheim, Norway
Lung Cancer 67:57-68. 2010..The pro-angiogenic AGGF1 mRNA and protein was highly overexpressed in all tumours and may serve as a target for anti-angiogenic treatment. Overexpression of NQO1 may render mesothelioma sensitive to the novel compound beta-Lapachone...
- Modification of dietary copper levels on the early stage of tumor-promotion with propylthiouracil in a rat two-stage thyroid carcinogenesis modelTomomi Shima
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
Chem Biol Interact 180:262-70. 2009..6 ppm. These results suggest an involvement of Cp and MT-1/2 on the thyroid tumor promotion that can be suppressed by dietary Cu level through inhibition of cell proliferation associated with altered redox balance...
- Reversible regulation of cell cycle-related genes by epigallocatechin gallate for hibernation of neonatal human tarsal fibroblastsJung Yoon Bae
Department of Medical Simulation Engineering, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
Cell Transplant 18:459-69. 2009..These results suggest that EGCG temporarily affects not only genes related to the cell cycle but also various other cellular functions...
- Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acidsKevin T Duffy
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA
Nucleic Acids Res 33:4914-21. 2005....
- 198 THE EFFECT OF SOURCE AND IN VITRO MATURATION ON THE ABUNDANCE OF MATERNAL mRNA OF SELECTED GENES IN FOLLICULAR BOVINE OOCYTES AND THEIR INFLUENCE ON IN VITRO DEVELOPMENTT Somfai
National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
Reprod Fertil Dev 23:199. 2011..Among the genes studied, only ATP1A1 was correlated with in vitro development...
- ENHANCED DEVELOPMENT OF THE XIPHOPHORUS MODEL SYSTEMRONALD WALTER; Fiscal Year: 2001....
- TRANSPOSON ACTIVE TRANSGENIC XIPHOPHORUSRONALD WALTER; Fiscal Year: 2003..abstract_text> ..
- THE XIPHOPHORUS GENETIC STOCK CENTERRONALD WALTER; Fiscal Year: 2006..abstract_text> ..
- TRANSCRIPTOME OF METASTATIC PROSTATE CANCERGennadi Glinsky; Fiscal Year: 2005..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
- Molecular Pathways of Host Susceptibility to LegionellaWILLIAM DIETRICH; Fiscal Year: 2006..abstract_text> ..
- GENETIC ANALYSIS OF LETHAL FACTOR SENSITIVITYWILLIAM DIETRICH; Fiscal Year: 2006..We also propose to search for human macrophage variation in LeTx susceptibility as a means to better understand the pathogenesis of human anthrax and perhaps provide an explanation of variation in human susceptibility to anthrax. ..
- Linking folate deficiency to changes in gene expressionKAREN KATULA; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Discovery and characterization of breast cancer genesJohn Hodgson; Fiscal Year: 2008..Finally, effects on in vivo tumorigenic potential will be assessed by evaluating tumor growth in immunedeficient mice. [unreadable] [unreadable]..