CXCL12

Summary

Gene Symbol: CXCL12
Description: C-X-C motif chemokine ligand 12
Alias: IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, stromal cell-derived factor 1, chemokine (C-X-C motif) ligand 12, intercrine reduced in hepatomas, pre-B cell growth-stimulating factor
Species: human

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
  4. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
  5. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
  6. ncbi Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 23:879-94. 2005
  7. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
  8. pmc HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    Cinzia Nobile
    Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
    J Virol 84:2282-93. 2010
  9. pmc Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    Yazan Alsayed
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, Department of Internal Medicine, University of Pittsburgh, PA, USA
    Blood 109:2708-17. 2007
  10. pmc Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    Hua Kang
    Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res 7:R402-10. 2005

Research Grants

  1. Brian F Volkman; Fiscal Year: 2016
  2. Rongshi Li; Fiscal Year: 2015
  3. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
  4. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2004
  5. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
  6. Yedidya Saiman; Fiscal Year: 2014
  7. Ramesh K Ganju; Fiscal Year: 2016
  8. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
  9. Sridhar Nimmagadda; Fiscal Year: 2016
  10. Sally Temple; Fiscal Year: 2016

Detail Information

Publications334 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Their respective ligands CXCL12/SDF-1alpha and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of ..
  2. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  3. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..Here we show that CXCL12, the only known natural ligand for CXCR4, binds to and signals through RDC1...
  4. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    ....
  5. pmc Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
    Yasushi Kojima
    Cancer Research UK Stromal Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester M20 4BX, United Kingdom
    Proc Natl Acad Sci U S A 107:20009-14. 2010
    ..This autocrine-signaling mechanism may prove to be an attractive therapeutic target to block the evolution of tumor-promoting CAFs...
  6. ncbi Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 23:879-94. 2005
    ....
  7. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
    ..These data suggest that MMPs may be important regulatory proteases in attenuating SDF-1 function and point to a deep convergence of two important networks, chemokines and MMPs, to regulate leukocytic activity in vivo...
  8. pmc HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    Cinzia Nobile
    Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
    J Virol 84:2282-93. 2010
    ..and spreading of infected cells to fibronectin, their spontaneous motility, and their migration toward chemokines (CXCL12, CCL3, and CCL19) were all significantly decreased...
  9. pmc Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    Yazan Alsayed
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, Department of Internal Medicine, University of Pittsburgh, PA, USA
    Blood 109:2708-17. 2007
    ..In this study, we sought to determine the effect of the chemokine SDF-1 (CXCL12) and its receptor CXCR4 on the migration and homing of MM cells...
  10. pmc Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer
    Hua Kang
    Wales College of Medicine, Cardiff University, Cardiff, UK
    Breast Cancer Res 7:R402-10. 2005
    ....
  11. pmc Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells
    Antoine Boudot
    UMR CNRS 6026, Molecular and Cellular Interactions, IRSET, University of Rennes 1, IFR 140, Rennes, France
    PLoS ONE 6:e20898. 2011
    CXCR4 and CXCR7 are the two receptors for the chemokine CXCL12, a key mediator of the growth effect of estrogens (E2) in estrogen receptor (ER)-positive breast cancers...
  12. ncbi Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
    Ryan Reca
    Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
    Blood 101:3784-93. 2003
    ..C3a is the first positive regulator of this axis to be identified...
  13. pmc Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4
    Yutaka Kofuku
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    J Biol Chem 284:35240-50. 2009
    The chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) and its G-protein-coupled receptor (GPCR) CXCR4 play fundamental roles in many physiological processes, and CXCR4 is a drug target for various diseases such as cancer metastasis ..
  14. doi Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow
    Menka Sharma
    Stem Cell and Gene Therapy Research Group, Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Defense Research and Development Organization, New Delhi, India
    Stem Cells Dev 20:933-46. 2011
    ..Hence, this review presents current knowledge of the mechanisms through which SDF-1/CXCR4 signaling promotes restoration of hematopoiesis by regulating the homing and engraftment of HSPCs...
  15. pmc The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice
    Tania N Petruzziello-Pellegrini
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 122:759-76. 2012
    ..Stx also enhanced the association of CXCR4, CXCR7, and SDF1 mRNAs with ribosomes...
  16. ncbi The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    C C Bleul
    The Center for Blood Research, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 382:829-33. 1996
    ....
  17. ncbi Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
    Blood Cells Mol Dis 32:52-7. 2004
    ....
  18. ncbi Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene
    M Shirozu
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Genomics 28:495-500. 1995
    ..cDNA and genomic clones of human SDF1 alpha and SDF1 beta (SDF1A and SDF1B) were isolated and characterized...
  19. ncbi CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12
    Sreenivasa R Chinni
    Department of Urology, Wayne State University School of Medicine and The Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Prostate 66:32-48. 2006
    ..Recent evidence suggests that similar mechanisms may be active in cancer metastasis. Previously, we showed that metalloproteases (MMPs), and in particular MMP-9, play a role in prostate cancer (PC) expansion in bone...
  20. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..PHACTR1 and 2q33 in WDR12) and six replicated prior observations (9p21, 1p13 near CELSR2-PSRC1-SORT1, 10q11 near CXCL12, 1q41 in MIA3, 19p13 near LDLR and 1p32 near PCSK9)...
  21. doi Stromal cell-derived factor-1/CXC receptor 4 and β1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells
    Wen Shih Huang
    Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taiwan
    J Cell Physiol 227:1114-22. 2012
    ..In summary, our findings elucidate the mechanisms of SDF-1/CXCR4 downstream signaling and provide insights into the function of SDF-1 in colon cancer cells...
  22. pmc E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution
    Soonyean Hwang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 287:22227-40. 2012
    ..The goal of these studies was to define the role for the chemokine CXCL12 in regulating E-cadherin during collective sheet migration during epithelial restitution...
  23. doi The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis
    S C McIver
    ARC Centre of Excellence in Biotechnology and Development, Discipline of Biological Sciences School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW 2308, Australia
    Andrology 1:517-29. 2013
    ..These tumours originate from carcinoma in situ (CIS) cells, which arise from dysfunctional gonocytes. CXCL12 and its receptors, CXCR4 and CXCR7, have been implicated in migration, proliferation and survival of gonocytes and ..
  24. pmc Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis
    Hongyan Li
    Tianjin Medical University Cancer Institute and Hospital and Research Center of Basic Medical Sciences, He Xi District, Tianjin 300060, China
    Nat Commun 4:1706. 2013
    The chemokine CXCL12 and its G-protein-coupled receptor CXCR4 control the migration, invasiveness and metastasis of breast cancer cells...
  25. doi Platelet-derived CXCL12 (SDF-1α): basic mechanisms and clinical implications
    M Chatterjee
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat, Tubingen, Germany
    J Thromb Haemost 11:1954-67. 2013
    Platelets are a major source of CXCL12 (stromal cell-derived factor -1α, SDF-1α) and store CXCL12 as part of their α-granule secretome. Platelet activation enhances surface expression and release of CXCL12...
  26. ncbi Leukocyte elastase negatively regulates Stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4
    Agustin Valenzuela-Fernandez
    Unite d Immunologie Virale, INSERM U485 de l Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 277:15677-89. 2002
    ..Our findings suggest that elastase-mediated proteolysis of SDF-1/CXCR4 is part of a mechanism regulating their biological functions in both homeostatic and pathologic processes...
  27. pmc Olfactomedin 4 suppresses prostate cancer cell growth and metastasis via negative interaction with cathepsin D and SDF-1
    Ling Chen
    Molecular and Clinical Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
    Carcinogenesis 32:986-94. 2011
    ..Taken together, these results suggest that OLFM4 negatively interacts with cathepsin D and SDF-1 and inhibits prostate cancer growth and bone metastasis...
  28. doi B lymphocytes that migrate to tuberculous pleural fluid via the SDF-1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
    Lian Feng
    Institute of Immunology, Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control Research of Ministry of Education, Sun Yat Sen University, Guangzhou, PR China
    Eur J Immunol 41:3261-9. 2011
    ..Collectively, these data demonstrate that Mycobacterium tuberculosis-specific B cells exist at local sites of infection in TP patients and this localization might influence the immune response to M. tuberculosis...
  29. doi Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1/CXCR4 and SDF-1/CXCR7 signaling
    Ming Ma
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Cancer Lett 312:1-10. 2011
    ..Our study suggests that MSCs are important for neuroblastoma metastasis via the secretion of SDF-1 and that such effect can be inhibited by AMD3100 or shRNA knockdown...
  30. pmc Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man
    Andrew J Boyle
    Department of Medicine, Division of Cardiology, University of California San Francisco, USA
    J Transl Med 9:150. 2011
    ..It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium...
  31. ncbi Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes
    M B Delgado
    Theodor Kocher Institute, University of Bern, Bern, Switzerland
    Eur J Immunol 31:699-707. 2001
    ..Owing to its availability on the surface of SDF-1-responsive cells and its rapid effect, cathepsin G is likely to play a significant role in down-regulating SDF-1 activity...
  32. ncbi CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis
    K Alagarasu
    Tuberculosis Research Centre ICMR, Chennai, India
    Indian J Med Res 130:444-50. 2009
    ..The aim of the present study was to find out whether chemokine, chemokine receptor and DC-SIGN gene polymorphisms were associated with susceptibility or resistance to HIV and HIV-TB in south India...
  33. doi Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal cell-derived factor-1/CXCR4 axis via Akt, ERK, and p38 signal transduction pathways
    Chung Heon Ryu
    Department of Biomedical Science, College of Medicine, Seoul St Mary s Hospital, The Catholic University of Korea, Seoul, Republic of Korea
    Biochem Biophys Res Commun 398:105-10. 2010
    ..In addition, SDF-1-induced actin polymerization was also blocked by these inhibitors. Taken together, these results demonstrate that Akt, ERK and p38 signal transduction pathways may be involved in SDF-1-mediated migration of hUCB-MSCs...
  34. pmc Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha
    R Salcedo
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Frederick Cancer Research and Development Center, Frederick, MD 21702 1202, USA
    Am J Pathol 154:1125-35. 1999
    ..Taken together, our data indicate that SDF-1alpha acts as a potent chemoattractant for endothelial cells of different origins bearing CXCR4 and is a participant in angiogenesis that is regulated at the receptor level by VEGF and bFGF...
  35. ncbi The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells
    Xia Wu
    Laboratory of Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai 200011, China
    Biol Reprod 70:1877-85. 2004
    ..Among these receptors, CXCR4 was found highly transcribed. We demonstrated afterward that both CXCR4 and CXCL12 (stromal cell-derived factor-1; SDF-1) were expressed in trophoblast cells...
  36. pmc SDF-1 is both necessary and sufficient to promote proliferative retinopathy
    Jason M Butler
    Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, Florida, USA
    J Clin Invest 115:86-93. 2005
    ..Together, these data demonstrate that SDF-1 plays a major role in proliferative retinopathy and may be an ideal target for the prevention of proliferative retinopathy...
  37. ncbi RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs
    Yusuke Koizumi
    Department of Viral Infection and International Health, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    AIDS Res Hum Retroviruses 23:713-9. 2007
    ..These results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs...
  38. pmc Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer
    Lei Xu
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 69:7905-10. 2009
    ..These data show that VEGF blockade up-regulates inflammatory pathways and NRP1, which should be evaluated as potential targets for improving anti-VEGF therapy...
  39. pmc Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk
    Lyndsay V Rhodes
    Department of Medicine, Section of Haematology and Medical Oncology, Tulane University Health Science Centre, New Orleans, Louisiana, USA
    Mol Cancer 9:295. 2010
    ..Therefore, we set out to investigate the impact of hMSCs on the oestrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7...
  40. pmc The inducible CXCR3 ligands control plasmacytoid dendritic cell responsiveness to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12
    Béatrice Vanbervliet
    Laboratory for Immunological Research, Schering Plough, 27 chemin des Peupliers, BP 11, 69571 Dardilly, France
    J Exp Med 198:823-30. 2003
    ..However, they migrate in response to the constitutive chemokine stromal cell-derived factor 1 (SDF-1)/CXCL12 and CXCR3 ligands synergize with SDF-1/CXCL12 to induce pDC migration...
  41. ncbi Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications
    Paola Cipriani
    University of L Aquila, L Aquila, Italy
    Arthritis Rheum 54:3022-33. 2006
    ..We undertook this study to determine whether an alteration of the SDF-1/CXCR4 axis might be involved in the pathogenetic mechanisms following ischemic damage during SSc...
  42. doi Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells
    Tzu Hsiu Lai
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 218:334-42. 2009
    ..Taken together, our results indicate that lung derived-SDF-1alpha enhances the invasiveness of chondrosarcoma cells by increasing alphavbeta3 integrin expression through the CXCR4/ERK/NF-kappaB signal transduction pathway...
  43. doi Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways
    Chun Yin Huang
    Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun Lin County, Taiwan
    J Cell Physiol 221:204-12. 2009
    ....
  44. ncbi The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
    E Oberlin
    Unite d Immunologie Virale, Institut Pasteur, Paris, France
    Nature 382:833-5. 1996
    ....
  45. ncbi CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells
    Jacob Hanna
    The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel
    Blood 102:1569-77. 2003
    ..We further demonstrate in vivo that invading EVTs that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands for CXCR3...
  46. pmc Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin
    James W Murphy
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8066, USA
    J Biol Chem 282:10018-27. 2007
    b>CXCL12 (SDF-1alpha) and CXCR4 are critical for embryonic development and cellular migration in adults. These proteins are involved in HIV-1 infection, cancer metastasis, and WHIM disease...
  47. ncbi Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G(0)/G(1) transition in CD34(+) cells: evidence for an autocrine/paracrine mechanism
    Jean Jacques Lataillade
    Laboratoire d Immunologie Cellulaire, centre de transfusion sanguine des armées Jean Julliard, Clamart Cedex, France
    Blood 99:1117-29. 2002
    ....
  48. ncbi Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells
    Hui Peng
    Laboratory of Neurotoxicology, The Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha 68198 5215, USA
    J Neurosci Res 76:35-50. 2004
    ..Ultimately, this study suggested that SDF-1alpha can influence NPC function through CXCR4 and that CXCR4 is functional on NPC...
  49. ncbi Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation
    Carola Porcile
    Department of Oncology, Biology and Genetics, Section of Pharmacology, University of Genoa, Largo Rosanna Benzi, 10 16132 Genova, Italy
    Exp Cell Res 308:241-53. 2005
    ..These results suggest a possible important "cross-talk" between SDF-1/CXCR4 and EGFR intracellular pathways that may link signals of cell proliferation in ovarian cancer...
  50. ncbi Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
    A M Lambeir
    Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1 S6, B 2610 Antwerp, Belgium
    J Biol Chem 276:29839-45. 2001
    ..catalytic parameters for a relevant selection of chemokines (CCL3b, CCL5, CCL11, CCL22, CXCL9, CXCL10, CXCL11, and CXCL12) previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed truncation...
  51. ncbi Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
    Yan Xi Sun
    Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, Michigan 48109 1078, USA
    J Cell Biochem 89:462-73. 2003
    ..The chemokine stromal-derived factor-1 (SDF-1 or CXCL12) and its receptor CXCR4 are now known to modulate the migration and survival of an increasing array of normal and ..
  52. ncbi Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients
    Jan Dimberg
    Department of Natural Science and Biomedicine, University College of Health Sciences, Box 1026, SE 551 11 Jönköping, Sweden
    Int J Mol Med 19:11-5. 2007
    The chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1), is a small protein that regulates leukocyte trafficking and is variably expressed in a number of normal and cancer tissues...
  53. doi Expression of platelet-bound stromal cell-derived factor-1 in patients with non-valvular atrial fibrillation and ischemic heart disease
    Konstantinos Stellos
    Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    J Thromb Haemost 10:49-55. 2012
    ....
  54. pmc Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma
    Julie Liberman
    Pediatric Oncology Research Unit, Department of Pediatrics, Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 7:e43665. 2012
    ..The chemokine CXCL12, and its receptors CXCR4 and CXCR7 have been involved in tumor progression and dissemination...
  55. ncbi Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
    J P Ioannidis
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Ann Intern Med 135:782-95. 2001
    ..Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results...
  56. ncbi Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation
    Yue Sun
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People s Republic of China
    J Biol Chem 277:49212-9. 2002
    ....
  57. ncbi Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1
    Huanliang Liu
    Department of Laboratory Medicine, University of Washington School of Medicine, 1959 N E Pacific Street, Seattle, WA 98195 8070, USA
    J Infect Dis 190:1055-8. 2004
    ..2% in ES individuals vs. 0.0% in HIV-1-seropositive individuals; P=.011)...
  58. ncbi Stromal cell-derived factor 1 (SDF-1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti-inflammatory agents
    Yang Soo Kim
    Center for Orthopaedic Research and Columbia University Center for Shoulder, Elbow, and Sports Medicine, Columbia University, New York, NY, USA
    J Orthop Res 24:1756-64. 2006
    ..demonstrated in a previous study that many inflammatory cytokines, including stromal cell-derived factor 1 (SDF-1, CXCL12), are increased in the subacromial bursa [Blaine et al. 2005. J Shoulder Elbow Surg 14(Suppl 1):84S-89S]...
  59. doi Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians
    Omkar Chaudhary
    Department of Biochemistry, Room No 3002, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    J Clin Virol 43:196-201. 2008
    ..We examined the SNP of SDF1-3'A by PCR-restriction fragment length polymorphism (RFLP) and repeat region polymorphisms in DC-SIGN and DC SIGNR ..
  60. ncbi Better CD4+ T cell recovery in Brazilian HIV-infected individuals under HAART due to cumulative carriage of SDF-1-3'A, CCR2-V64I, CCR5-D32 and CCR5-promoter 59029A/G polymorphisms
    Paula O Rigato
    Laboratírio de Dermatologia e Imunodeficências LIM 56, Faculdade de Medicina da USP, Brazil
    Curr HIV Res 6:466-73. 2008
    ..These results highlight the possibility that these genetic traits can be useful to identify patients at risk for faster progression to AIDS or therapeutic failure...
  61. doi Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma
    Chi Chung Chang
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Clin Chem Lab Med 47:412-8. 2009
    ....
  62. doi CXCR4 and SDF-1 production are stimulated by hepatocyte growth factor and promote glioma cell invasion
    Hanjun Tu
    Department of Surgery, Renmin Hospital of Wuhan University, Wuhan, China
    Onkologie 32:331-6. 2009
    ..In this study, we investigated the ability of HGF to promote the proliferation and invasion of U251n cells; we also tested the effects of HGF on stromal cell-derived factor 1 (SDF1) and CXCR4 mRNA expression.
  63. pmc Ovarian cancer-derived lysophosphatidic acid stimulates secretion of VEGF and stromal cell-derived factor-1 alpha from human mesenchymal stem cells
    Eun Su Jeon
    Medical Research Center for Ischemic Tissue Regeneration, Medical Research Institute, School of Medicine, Pusan National University, Yangsan 626 870, Korea
    Exp Mol Med 42:280-93. 2010
    ..These results suggest that cancer-secreted LPA induces differentiation of hASCs to cancer-associated fibroblasts through multiple signaling pathways involving Rho kinase, ERK, PLC, and phosphoinositide-3-kinase...
  64. pmc Stromal derived factor-1 regulates bone morphogenetic protein 2-induced osteogenic differentiation of primary mesenchymal stem cells
    Naobumi Hosogane
    Muskuloskeletal Integrity Program, Hospital for Special Surgery, New York, NY 10021, USA
    Int J Biochem Cell Biol 42:1132-41. 2010
    ..These data provide novel insights into molecular mechanisms underlying MSC osteogenesis, and will contribute to the development of MSC therapies for enhancing bone formation and regeneration in broad orthopaedic situations...
  65. pmc SDF-1α secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7
    Benjamin Bakondi
    Department of Medicine, Stem Cell Core, University of Vermont, Colchester, Vermont 05446, USA
    Stem Cells Dev 20:1021-9. 2011
    ..To determine whether MSC-secreted SDF-1 influenced mNPC survival, we used lentiviral short hairpin RNA against SDF1 (shSDF-1) to knockdown SDF-1 expression in CD133dMSCs...
  66. doi Estrogen induces stromal cell-derived factor 1 (SDF-1/CXCL12) production in human endometrial stromal cells: a possible role of endometrial epithelial cell growth
    Akihiro Tsutsumi
    Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan
    Fertil Steril 95:444-7. 2011
    Estradiol enhanced stromal cell-derived factor 1 (SDF-1/CXCL12) production levels in human endometrial stromal cells (ESCs) in a time- and dose-dependent manner that could be completely abolished by ICI 182,780 (estrogen receptor ..
  67. doi Cyclic variability of stromal cell-derived factor-1 and endothelial progenitor cells during the menstrual cycle
    Elzafir Elsheikh
    Department of Clinical Science, Intervention and Technology CLINTEC, Division of Transplantation Surgery, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Int J Mol Med 27:221-6. 2011
    ..Furthermore, vascular endothelial growth factor receptors and Tie-2 EPCs showed a cyclic pattern over the MC. Our results point to SDF-1 as a novel mediator of EPC trafficking during the MC...
  68. pmc Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation
    Ashok Kumar
    Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 186:951-8. 2011
    ..showed that CXCR4 and the TCR physically associate and form a heterodimer upon stromal cell-derived factor-1 or CXCL12 (SDF-1) stimulation in human T cells to prolong ERK activation and, thereby, lead to gene upregulation and ..
  69. pmc Stromal-derived factor-1[alpha] correlates with circulating endothelial progenitor cells and with acute lesion volume in stroke patients
    Tanya Bogoslovsky
    Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, National Institute of Nursing Research, National Institutes of Health, 12725 Twinbrook Parkway, Rockville, MD 20852, USA
    Stroke 42:618-25. 2011
    ..We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and stroke severity in acute stroke patients...
  70. doi Interleukin-1β stimulates stromal-derived factor-1α expression in human subacromial bursa
    Theodore A Blaine
    Rhode Island Shoulder and Elbow Service, Brown Alpert Medical School, 2 Dudley Street, Suite 200, Providence, Rhode Island 02905, USA
    J Orthop Res 29:1695-9. 2011
    ..IL-1β produced by bursal syvoviocytes and inflammatory cells in the human subacromial bursa is an important signal in the inflammatory response that occurs in subacromial bursitis and rotator cuff disease...
  71. pmc CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma
    Bao Cheng Zhao
    Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
    World J Gastroenterol 17:2389-96. 2011
    ..To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma...
  72. doi MicroRNA-126 modulates endothelial SDF-1 expression and mobilization of Sca-1(+)/Lin(-) progenitor cells in ischaemia
    Coen van Solingen
    Department of Nephrology, LUMC, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Cardiovasc Res 92:449-55. 2011
    ..Based on the seed sequence, miR-126 can also be predicted to regulate vasculogenesis by modulating the endothelial expression of stromal cell-derived factor-1 (SDF-1)...
  73. pmc Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendriti
    Cristina Delgado-Martín
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, 28040 Madrid, Spain
    J Biol Chem 286:37222-36. 2011
    ..As maDCs are exposed to chemokine CXCL12 (receptors CXCR4 and CXCR7) during their migration, its functions are amenable to be regulated by this ligand...
  74. ncbi CXCL12 activates a robust transcriptional response in human prostate epithelial cells
    Lesa A Begley
    Department of Urology and the Comprehensive Cancer Center, University of Michigan, 1500 East Medical Center zDrive, Ann Arbor, MI 48109, USA
    J Biol Chem 282:26767-74. 2007
    b>CXCL12 is a CXC-type chemokine that plays important roles in hematopoiesis, development, and organization of the immune system and supports the survival or growth of a variety of normal or malignant cell types...
  75. ncbi Human first-trimester trophoblast cells recruit CD56brightCD16- NK cells into decidua by way of expressing and secreting of CXCL12/stromal cell-derived factor 1
    Xia Wu
    Laboratory of Reproductive Immunology, Institute of Obstetrics and Gynecology, Fudan University, Shanghai, China
    J Immunol 175:61-8. 2005
    ..The first-trimester human trophoblasts were found expressing CXCL12/stromal cell-derived factor 1, the specific ligand of CXCR4, by way of in situ hybridization and ..
  76. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..X4 and X4/R5 gp120 inhibited B cell chemotaxis toward CXCL12, CCL20, and CCL21 by 40-50%, whereas R5 gp120 decreased inhibition by 20%...
  77. ncbi The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase
    Jing Zhang
    Department of Oncology, University of Calgary, Calgary, Alberta, Canada
    Carcinogenesis 26:2069-77. 2005
    ..Herein, we have tested the ligand of CXCR4, stromal cell derived factor-1alpha (SDF-1alpha, CXCL12), on the response of human glioma cells...
  78. ncbi Cloning and characterizing mutated human stromal cell-derived factor-1 (SDF-1): C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling, but not in CXCR4 binding affinity
    Yi Tan
    Department of Clinical Pharmacology, Pharmacy School of Jinan University, Guangzhou, China
    Exp Hematol 34:1553-62. 2006
    ..A novel C-terminal alpha-helix-defective mutant of human stromal cell-derived factor-1 (SDF-1), hSDF-154, was designed and produced in order to develop an optimal CXC chemokine receptor 4 (CXCR4) antagonist...
  79. doi A cross-talk between stromal cell-derived factor-1 and transforming growth factor-beta controls the quiescence/cycling switch of CD34(+) progenitors through FoxO3 and mammalian target of rapamycin
    Aurélie Chabanon
    Institut National de la Sante et de la Recherche Medicale, Villejuif, France
    Stem Cells 26:3150-61. 2008
    ....
  80. doi SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer
    Shih Ching Chang
    Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Ann Surg Oncol 16:2323-30. 2009
    ....
  81. pmc Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer
    Edneia A S Ramos
    Department of Basic Pathology, Federal University of Parana, Curitiba, Brazil
    BMC Cancer 10:23. 2010
    b>CXCL12 is a chemokine that is constitutively expressed in many organs and tissues. CXCL12 promoter hypermethylation has been detected in primary breast tumours and contributes to their metastatic potential...
  82. ncbi CXC chemokine ligand 12 (stromal cell-derived factor 1 alpha) and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture
    Tianqian Zhang
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:5856-63. 2005
    ..CTL migration was mediated by chemokine receptor CXCR4 expressed by the CTL and CXCL12 (stromal cell-derived factor 1alpha) secreted by tumor cells, as evidenced by blockage of CTL migration by Abs to ..
  83. doi SDF-1 and CCR5 genes polymorphism in patients with head and neck cancer
    Bijan Khademi
    Department of ENT, Shiraz University of Medical Sciences, Shiraz, Iran
    Pathol Oncol Res 14:45-50. 2008
    The frequency of SDF1-3'A and CCR5Delta32 in patients with head and neck cancer were determined in this study...
  84. doi Low-dose radiation augments vasculogenesis signaling through HIF-1-dependent and -independent SDF-1 induction
    Oren Z Lerman
    Institute of Reconstructive Plastic Surgery, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA
    Blood 116:3669-76. 2010
    ..IR activates a novel pathway stimulating EC migration directly through the expression of SDF-1 independent of HIF-1α induction. These observations might be exploited for stimulation of wound healing or controlling tumor angiogenesis...
  85. pmc HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
    Orit Kollet
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Clin Invest 112:160-9. 2003
    ..Our results suggest the potential of hematopoietic CD34+/CXCR4+cells to respond to stress signals from nonhematopoietic injured organs as an important mechanism for tissue targeting and repair...
  86. pmc Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells
    Hui Liu
    The 3rd Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China
    Cell Mol Immunol 5:373-8. 2008
    ..Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC...
  87. doi SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia
    Dah Yuu Lu
    Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan, ROC
    Eur J Pharmacol 613:146-54. 2009
    Stromal cell-derived factor-1 (SDF-1), also known as CXCL12, and its receptor CXC chemokine receptor 4 (CXCR4) express in various kinds of cells in central nervous system...
  88. pmc RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Blood 114:619-29. 2009
    ..Stromal cell-derived factor-1 (SDF1) regulates homing of MM cells to the BM...
  89. pmc CXCR4 regulates the early extravasation of metastatic tumor cells in vivo
    Peter Gassmann
    Department of General and Visceral Surgery, University Hospital Muenster, Muenster, Germany
    Neoplasia 11:651-61. 2009
    ..Immunohistochemistry revealed that the CXCR4 ligand CXCL12 is expressed by endothelial cells and likely Kupffer cells lining the liver sinusoids...
  90. ncbi CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal cell carcinoma
    Linhui Wang
    The Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Oncol Rep 22:1333-9. 2009
    ..These findings may be applied to the search for ways to inhibit RCC, as well as to many other questions that involve CXCR4 such as normal hematopoiesis, tissue regeneration, stem cell research and HIV infection...
  91. pmc CXCL12 chemokine expression and secretion regulates colorectal carcinoma cell anoikis through Bim-mediated intrinsic apoptosis
    Luke J Drury
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    PLoS ONE 5:e12895. 2010
    ..Previously we have shown re-establishment of CXCL12 expression in colorectal carcinoma cells inhibits metastasis by enhancing anoikis sensitivity...
  92. ncbi beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4
    Z J Cheng
    Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    J Biol Chem 275:2479-85. 2000
    ....
  93. ncbi Role of stromal-derived factor-1 in the hematopoietic-supporting activity of human mesenchymal stem cells
    Nancy Van Overstraeten-Schlögel
    Department of Medicine Hematology, University of Liege, Liege, Belgium
    Eur J Haematol 76:488-93. 2006
    ..Our data further suggest that SDF-1 stimulates retention of HSPC in MSC niches which expose them to stimulatory and inhibitory factors in a paracrine manner...
  94. ncbi Identification and expression of novel isoforms of human stromal cell-derived factor 1
    Lan Yu
    Cardiovascular Division, Lilly Research Laboratories, Eli Lilly and Company, DC0434, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Gene 374:174-9. 2006
    ..The conditioned media from transfected cells can stimulate cell migration in a CXCR4-dependent manner. These data suggest that the novel SDF-1 splice variants encode functional proteins...
  95. ncbi Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    Konstantinos Stellos
    Medizinische Klinik III, Eberhard Karls Universitätsklinikum Tübingen, Tubingen, Germany
    Circulation 117:206-15. 2008
    ..The chemokine stromal cell-derived factor-1 (SDF-1) regulates homing of CD34+ stem cells. We evaluated the role of platelet-derived SDF-1 in adhesion and differentiation of human CD34+ cells into endothelial progenitor cells...
  96. doi Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis
    Takayuki Kobayashi
    Department of Basic Pathology, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Breast Cancer Res Treat 123:733-45. 2010
    ..046). SDF-1 status is a significant prognostic factor and may be clinically useful for assigning adjuvant therapy to patients with ER-positive invasive breast cancers...
  97. pmc Hypoxia- and vascular endothelial growth factor-induced stromal cell-derived factor-1alpha/CXCR4 expression in glioblastomas: one plausible explanation of Scherer's structures
    David Zagzag
    Microvascular and Molecular Neuro oncologyLaboratory, Department of Pathology, MSB 130, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Am J Pathol 173:545-60. 2008
    ..These studies offer one plausible molecular basis and explanation of the formation of Scherer's structures in glioma patients...
  98. ncbi CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
    Shailesh Singh
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    Lab Invest 84:1666-76. 2004
    ..The current study evaluates the molecular mechanisms of CXCL12 and CXCR4 in prostate cancer cell migration and invasion...
  99. doi Down-regulation of CXCL12 mRNA expression by promoter hypermethylation and its association with metastatic progression in human breast carcinomas
    Wei Zhou
    Shandong University School of Medicine, Wenhua Xi Road, Jinan, Shandong, 250012, People s Republic of China
    J Cancer Res Clin Oncol 135:91-102. 2009
    Not only is the expression of CXCR4 on breast cancers a key determinant of tumor metastasis, CXCL12 exhibiting peak levels of constitutive expression in organs representing the first destinations of cancer metastasis, but is proposed to ..
  100. doi Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas
    Federica Barbieri
    Laboratory of Pharmacology, Department of Oncology, Biology and Genetics, University of Genova, Viale Benedetto XV 2, Genoa, Italy
    Clin Cancer Res 14:5022-32. 2008
    ..We evaluated the expression of the chemokine stromal cell-derived factor 1 (SDF1) and its receptor CXCR4 in human pituitary adenomas and normal pituitary tissues and their role in cell ..
  101. ncbi Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival
    Mambarath A Jaleel
    Department of Pediatrics, Division of Neonatology, Women and Infants Hospital of Rhode Island and Brown Medical School, Providence, RI 02905, USA
    Mol Hum Reprod 10:901-9. 2004
    Stromal cell-derived factor-1 (SDF-1 or CXCL12) is the physiologic ligand for the chemokine receptor CXCR4. CXCR4-mediated signalling regulates cell migration and apoptosis in certain haematopoietic and neuronal cells...

Research Grants63

  1. Brian F Volkman; Fiscal Year: 2016
    ..Stromal cell-derived factor-1 (SDF1/ CXCL12) and its cognate receptors CXCR4 and CXCR7 are essential for life and play unique roles in human development, HIV ..
  2. Rongshi Li; Fiscal Year: 2015
    ..of this project is to discover novel chemical probes that are capable of potently and selectively disrupting the CXCL12/CXCR4 protein-protein binding...
  3. CXCR4-Vagal Tone and Gastric motility
    Richard C Rogers; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Stromal cell derived factor [SDF1;also referred to as CXCL12] is a pleiotropic chemokine that is essential for the normal development of neurons and glia but also functions in the initiation of glial ..
  4. CXCR4 Expression and Function in Astrocytes
    ETTY BENVENISTE; Fiscal Year: 2004
    ..The findings forthcoming from these studies will provide the first biological assessment of CXCR4 expression in the brain, thereby setting the foundation for future therapeutic manipulation of this critical chemokine receptor. ..
  5. HIV, Chemokine Receptors, and Vascular Smooth Muscle
    ALISON SCHECTER; Fiscal Year: 2007
    ..Macrophage inflammatory protein-1 beta (MIP-1beta, CCL4) and stromal cell-derived protein (SDF-1, CXCL12) are the endogenous ligands for CCR5 and CXCR4, respectively...
  6. Yedidya Saiman; Fiscal Year: 2014
    ..Stromal cell derived factor-11 (SDF-11/CXCL12), is a chemokine that promotes retention of hematopoietic stem cells in the bone marrow, cancer metastasis, ..
  7. Ramesh K Ganju; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The chemokine receptor CXCR4 and its ligand CXCL12 play a critical role in breast cancer metastasis...
  8. Oncolytic Viruses with Therapeutic Genes in the Treatment of Breast Cancer
    DANUTA B KOZBOR; Fiscal Year: 2013
    ..results demonstrated that oncolytic vaccinia virus (OVV) expressing an antagonist of the CXCR4 receptor for CXCL12 chemokine (OVV- CXCR4-A-Fc) was more effective in inhibiting growth of triple-negative (TN) breast carcinomas 4T1 ..
  9. Sridhar Nimmagadda; Fiscal Year: 2016
    ..The stromal-derived factor SDF-1 (or CXCL12) is secreted by stroma in potential metastatic sites and attracts circulating chemokine receptor 4 (CXCR4) ..
  10. Sally Temple; Fiscal Year: 2016
    ..molecular events underlying age-related declines in NSC activity by exploring the role that the chemokine SDF1 and the corresponding CXCR4 receptor play in the aging process...
  11. John S Yu; Fiscal Year: 2014
    ..AIM 2: Test the hypothesis that SDF1 will increase a6 integrin expression and EGFR expression on BM-NSCs and that this effect will increase the adhesion ..
  12. SDF-1A AND MIP-II INTERACTIONS WITH CHEMOKINE RECEPTORS
    Elias Lolis; Fiscal Year: 2002
    ..The ultimate aim of this work is to use the information generated from these studies in the design of small molecule receptor antagonists for the treatment of HIV-1. ..
  13. Richard M Ransohoff; Fiscal Year: 2014
    ..Specific research aims are: Aim 1: To define how chemokine CXCL12 signals selectively to monocytes to promote transmigration of lymphocytes...
  14. Robyn S Klein; Fiscal Year: 2016
    ..In published studies we have determined that the chemokines CXCL12 and CXCL10 control leukocyte access to the central nervous system (CNS) parenchyma at the blood-brain barrier (BBB)..
  15. Ashlee V Moses; Fiscal Year: 2014
    ..KS tumor cells (spindle cells) express both of the CRs (CXCR4 and RDC1/CXCR7) for one of the key chemokines (SDF-1/CXCL12) involved in tumor metastasis and angiogenesis, and our preliminary data shows that KSHV induces the expression ..
  16. CXC Chemokines in Cancer
    Robert M Strieter; Fiscal Year: 2010
    ..The CXC chemokine, CXCL12, and its receptor, CXCR4 promote metastases of a variety of solid tumors...
  17. G protein-coupled receptor kinase 3 regulation of leukocyte function in inflammat
    TERESA KATHLEEN TARRANT; Fiscal Year: 2013
    ..Although most chemokine receptors have multiple ligands, CXCR4 is unique in its monogamous relationship with CXCL12 (SDF-1)...
  18. The Regulatory Role of PTEN on CXCR4-mediated Metastasis in Prostate Cancer Cells
    MAHANDRANAUTH ANAND CHETRAM; Fiscal Year: 2011
    ..on the cell surface of prostate cancer cells, which directs metastatic cells to tissues where its ligand SDF1[unreadable] is overexpressed...
  19. Nicole Salazar; Fiscal Year: 2014
    ..CXCR7 can heterodimerize with CXCR4, bind to SDF-1 (CXCL12), and CXCL11...
  20. JOHN ROLAND BETHEA; Fiscal Year: 2016
    ..Finally it has been previously demonstrated that CXCL12 (SDF-1) and its receptors (CXCR4 and CXCR7) support oligogenesis and neurite extension on inhibitory substrates...
  21. Cimona V Hinton; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Upon activation by stromal cell derived factor 1 alpha (SDF1 alpha), the G-protein-coupled chemokine receptor, CXCR4, generates signals that eventually lead to the metastatic spread and survival of ..
  22. Glycosaminoglycans and Cell Traffic in the Lymphatic Microenvironment
    Mark M Fuster; Fiscal Year: 2012
    ..CS) mediate two critical chemokine functions: (i) the scaffolding of major lymphatic chemokines (such as CCL21 and CXCL12) in peri-lymphatic spatial gradients that appear to be held by the glycans, and (2) the unique presentation of ..
  23. G-protein Signaling in Zebrafish Primordial Germ Cell Migration
    Fang Lin; Fiscal Year: 2010
    ..abstract_text> ..
  24. Ann Richmond; Fiscal Year: 2016
    ..this study: 1) Using an immunocompetent mouse model we will determine whether manipulation of CCL2, CCL5, CXCL1, CXCL12 and/or TGF-beta levels will differentially effect the recruitment of anti- or pro-tumor leukocytes into the ..
  25. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..Additionally, chemokines (CCL3/MIP-11, CCL4/MIP-12, CXCL9/MIG, CXCL10/IP-10, CXCL12/SDF, and CCL5/RANTES) within these tissues will be examined to determine the extent of NK cell trafficking to the ..
  26. Paired lg-Like Receptor as a Regulator of Hematopoietic Stem Cell Function
    Ching Cheng Chen; Fiscal Year: 2012
    ..Research collaborations and resources will assist the candidate in the development of the skills and autonomy required to become a successful independent investigator. ..
  27. ALTERATIONS IN ADULT NEUROGENESIS DURING WEST NILE VIRUS ENCEPHALITIS
    MICHAEL JOHN VASEK; Fiscal Year: 2013
    ..For example, CXCL12 and CXCR4 are molecules that form a chemokine ligand-receptor pair that both directs migration and proliferation ..
  28. Niche-induced Signaling in Progenitor B Cell Development
    LESLIE ERIC SILBERSTEIN; Fiscal Year: 2013
    ..Niche cells, e.g. osteoblasts, vascular endothelial cells, IL-7 producing cells and CXCL12-abundant reticular (CAR) cells will be identified by immunohistology on longitudinal sections of femurs...
  29. Robert P Schleimer; Fiscal Year: 2016
    ..nasal polyp tissue contains very high levels of B lymphocytes, the B cell activator BAFF, the B cell chemokines CXCL12 and CXCL13, IgA and IgE...
  30. DOROTHY ANNE CROSS; Fiscal Year: 2016
    ..Proj 2 "Neuroprotective mechanisms of CXCL12 in CNS demyelinating diseases" is directed by R Klein, an established researcher on roles of chemokines in ..
  31. Regulation of CXCR4 by cognate and non-cognate ligands
    Elias Lolis; Fiscal Year: 2013
    CXCR4 is a G-protein coupled receptor activated by a sole chemokine agonist, CXCL12, and functions to cause the migration of cells to the appropriate anatomical location during embryonic development and in response to stress in adults...
  32. Mark M Fuster; Fiscal Year: 2015
    ..HS may mediate two critical chemokine functions: (1) scaffolding of major lymphatic chemokines (such as CCL21 and CXCL12) onto peri-lymphatic spatial gradients, and (2) unique clustered presentation of chemokines to cognate receptors ..
  33. Regulation of Stromal Derived Factor-1 Mediated Angiogenesis in Ischemic Brain
    Umadevi V Wesley; Fiscal Year: 2013
    ..Particularly, the chemokine stromal derived factor (SDF1) acting via its receptor CXCR4 plays a central role in promoting angiogenesis and progenitor cell recruitment...
  34. Pulmonary defense against aspergillus fumigatus
    Chad Steele; Fiscal Year: 2013
    ..fumigatus challenge, as are the chemokines CXCL12/SDF-1 and CCL2/MCP-1. These results suggest that Dectin-1 may control IL-17 levels in the lungs after A...
  35. Crystal Structures of CXCR4 complexed to CXCL12
    Elias Lolis; Fiscal Year: 2011
    ..by applicant): CXCR4 is a G-protein coupled receptor is activated by a sole physiological agonist, the chemokine CXCL12 and functions to cause the migration of cells to the appropriate anatomical location during embryonic development ..
  36. Olimpia Meucci; Fiscal Year: 2016
    ..from research conducted during previous funding periods that revealed novel and unexpected roles of the chemokine CXCL12, and its primary receptor CXCR4, on central neurons and glia...
  37. Dopamine alters CNS migration of uninfected and HIV infected leukocytes to SDF-1
    JOAN WEINBERGER BERMAN; Fiscal Year: 2012
    ..We have the novel finding that dopamine synergizes with the chemokine CXCL12 (SDF-1) in inducing uninfected human T lymphocyte and monocyte transmigration across an in vitro model of the ..
  38. Understanding the Mechanism Involved in Immune-mediated Cognitive Functioning
    MARIA L PALU; Fiscal Year: 2013
    ..provided by applicant): The long-term objective of the proposed study is to examine the role of the chemokine CXCL12, an immune system molecule, in cognitive functioning...
  39. Influence of Sex Steroids on HIV-1 Chemokine Coreceptor Expression in Women
    Amie L Meditz; Fiscal Year: 2013
    ..by flow cytometric analysis of whole blood and cervical CD4+ T cells;inducible and constitutive p-chemokine and CXCL12 production will be measured in whole blood and cervical lavage specimens by ELISA;PBMC CCR5, CXCR4, and CCL5 mRNA ..
  40. Chemokine receptor-4 regulation of Beta adrenergic-mediated calcium channel
    Sima T Tarzami; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The chemokine, Stromal Cell Derived Factor-1 (SDF1) (also known as, CXCL12) and its major receptor, CXCR4, have long been thought to have a negative impact on myocardial function, however, there is ..
  41. Brian F Volkman; Fiscal Year: 2014
    ..recognition in the chemokine family by solving the NMR structure of a complex between the chemokine SDF1/CXCL12 and a sulfotyrosine-containing fragment of its receptor CXCR4...
  42. Inhibition of the SDF-1/CXCR4 axis as preventive therapy for radiation-induced pu
    HUI KUO contact SHU; Fiscal Year: 2010
    ..Stromal cell-derived factor 1 (SDF-1/CXCL12) is a chemokine that through interactions with its receptor CXCR4 may play an important role in the fibrotic ..
  43. Suzette Laing; Fiscal Year: 2016
    ..In atherosclerosis related pathology, it was shown to reduce the size of the vascular lesions by activation of the CXCL12/CXCR4 axis to mobilize and incorporate endothelial progenitor cells at the site of injury...
  44. LISA MADALEN NISWANDER; Fiscal Year: 2015
    ....
  45. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..Given the pivotal role of Slit/Robo signaling in cell-cell interactions, and known antagonism of the CXCL12/CXCR4 axis we predict that Slit2- mediated regulation of HSCs is accomplished by alterations in HSC-niche ..
  46. CHEMOKINE RECEPTORS AND ITP AND HIV THROMBOCYTOPE
    Shahin Rafii; Fiscal Year: 2002
    ..Stromal Derived Factor 1 (SDF1) which is the ligand for the CXCR4, promotes transmigration of MKs through BMEC monolayers...
  47. Plerixafor/G-CSF with Sorafenib for Acute Myelogenous Leukemia with FLT3-ITD Muta
    MICHAEL W ANDREEFF; Fiscal Year: 2012
    ..CXCR4 inhibitor AMD3100, G-CSF and Sorafenib will be administered sequentially to patients with advanced myeloid leukemia. ..
  48. The SDF1-CXCR4 Axis in Cardiac Homeostasis and Regeneration
    Gregg Rokosh; Fiscal Year: 2011
    ..Stromal cell derived factor 11 (SDF1), and its receptor, CXCR4 are key components of the biological system that regulates hematopoiesis and ..
  49. Laura F Gibson; Fiscal Year: 2014
    ..to the current application indicate that primary human osteoblasts exposed to melphalan or VP-16 have diminished CXCL12 expression and chemotactic support and altered support of CD34+ bone marrow cell differentiation...
  50. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012
    ..Recently, chemokine receptor CXCR4 and its ligand CXCL12 have been shown to play an important role in lung cancer progression and metastasis...
  51. Terry J Smith; Fiscal Year: 2015
    ..They express the chemokine receptor, CXCR4 and migrate to tissue injury in response to CXCL12. We have found that TAO orbital tissue comprises two discrete cell populations, including CD34+ and CD34- ..
  52. Genetic analysis of stem cell maintenance in vivo
    Sean J Morrison; Fiscal Year: 2012
    ..Angiopoietin-1 (Ang-1), Stem Cell Factor (SCF), and CXCL12 are all genetically required for maintenance of normal numbers of HSCs but none of these factors have been ..
  53. The Role of the CXCR4/CXCL12 axis in endometriosis
    ABIGAIL RUIZ-RIVERA; Fiscal Year: 2013
    ..of the endometrium, namely epithelial (EEC) and stromal (HESC) cells, show a differential expression of CXCR4 and CXCL12 proteins: endometrial epithelial cells express higher CXCR4 levels than stromal cells;conversely, endometrial ..
  54. Contribution of the vascular niche to the hematopoietic reconstitution.
    Shahin Rafii; Fiscal Year: 2012
    ..pathways and to define the mechanism whereby angiogenic factors, specifically the VEGF-A isoforms, PlGF and SDF1 elaborated by specific subsets of the hematopoietic cells support assembly and remodeling of BM's "Vascular ..
  55. Ravi Bhatia; Fiscal Year: 2016
    ..Our results indicate that decreased expression of the chemokine CXCL12 by CML BM mesenchymal cells, in addition to contributing to reduced LTHSC homing and retention, may also support ..
  56. Maintenance of the Hematopoietic Stem Cell Niche Monocytes and Macrophages
    Andrew Chow; Fiscal Year: 2012
    ..numbers and in vivo depletion of these populations is correlated with HSPC mobilization and reduction in BM CXCL12, an HSPC retention chemokine...
  57. Cellular and Molecular Regulation of Thrombopoiesis
    Ramesh A Shivdasani; Fiscal Year: 2012
    ..that myosin-IIA inhibition of platelet release is normally lifted when mature MKs encounter the chemokine Sdf-1 (CXCL12), which down-regulates cellular Rho activity. In Specific Aim 1 we propose critical tests of these hypotheses...
  58. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    ..Specific Aim 4 will investigate the role of ACE2/Ang (1-7)/Mas in counteracting ACE/Ang II/AT1 in the efficacy of EPCs transplantation for promoting repair after ischemic stroke. ..
  59. Paul S Frenette; Fiscal Year: 2016
    ..These putative Nestin+ niche cells express high levels of core genes regulating HSC retention (Cxcl12, Kit ligand, Vcam-1, Angiopoietin-1), which are downregulated by the administration of the HSC mobilizer ..
  60. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..has found that normal human brain and mouse spinal cord tissues exhibit ablumenal localization of the chemokine CXCL12 at their vasculature...
  61. Elena Tourkina; Fiscal Year: 2016
    ..the chemokine receptor CXCR4 by scleroderma monocytes and their extremely active migration toward the CXCR4 ligand CXCL12. In vivo in the mouse bleomycin model system, CSD inhibits fibrosis, the overexpression of CXCR4 by monocytes, and ..
  62. DEFECTIVE FOREBRAIN DEVELOPMENT IN MUTANT MICE
    SAMUEL JEREMY PLEASURE; Fiscal Year: 2013
    ..5, at least two of which are responsible for producing specific secreted signals controlling cortical development (Cxcl12 and RA)...
  63. GLUCOCORTICOSTEROID ACTION IN INFLAMMATORY DISEASE
    Robert Schleimer; Fiscal Year: 2009
    ..nasal polyp tissue contains very high levels of B lymphocytes, the B cell activator BAFF, the B cell chemokines CXCL12 and CXCL13, IgA and IgE...