CTLA 4

Summary

Gene Symbol: CTLA 4
Description: cytotoxic T-lymphocyte associated protein 4
Alias: ALPS5, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte protein 4, CD152 isoform, celiac disease 3, cytotoxic T lymphocyte associated antigen 4 short spliced form, cytotoxic T-lymphocyte-associated serine esterase-4, insulin-dependent diabetes mellitus 12, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Species: human

Top Publications

  1. ncbi Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes
    Akane Ide
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Autoimmun 22:73-8. 2004
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
  3. ncbi Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
  4. doi CTLA-4 +49A>G polymorphism is associated with advanced non-small cell lung cancer prognosis
    Bao Song
    Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Academy of Medical Sciences, Jinan, China
    Respiration 82:439-44. 2011
  5. doi Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer
    Sandra Salvi
    Department of Pathology, IRCCS AOU San Martino IST, Genoa, Italy
    Cancer Immunol Immunother 61:1463-72. 2012
  6. pmc Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:19396-401. 2008
  7. ncbi CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism
    B Vaidya
    Department of Endocrinology, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 58:732-5. 2003
  8. doi In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium
    Hui Qi Qu
    Department of Pediatrics, McGill University, Montreal, QC, Canada H4H 2P4
    Hum Mol Genet 19:2534-8. 2010
  9. doi Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population
    K Suwalska
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland
    Hum Immunol 69:193-201. 2008
  10. doi Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children
    I H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 63:1031-9. 2008

Research Grants

  1. CRAIG LEE SLINGLUFF; Fiscal Year: 2014
  2. IL-2 scintigraphy as a guide to cancer immunotherapy
    SVETOMIR NENAD MARKOVIC; Fiscal Year: 2013
  3. Michail Sitkovsky; Fiscal Year: 2016
  4. Bin Zhang; Fiscal Year: 2015
  5. Robert H Vonderheide; Fiscal Year: 2015
  6. Glenn Dranoff; Fiscal Year: 2014
  7. Walter J Storkus; Fiscal Year: 2016
  8. KARL D WITTRUP; Fiscal Year: 2016
  9. Combination immunotherapies for the treatment of melanoma
    Michael W Fanger; Fiscal Year: 2013
  10. Antoni Ribas; Fiscal Year: 2015

Detail Information

Publications396 found, 100 shown here

  1. ncbi Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes
    Akane Ide
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Autoimmun 22:73-8. 2004
    ..These results suggest that the IL-18 gene polymorphism is associated with a type 1 diabetes susceptibility, and there might be a gene-gene interaction between IL-18 gene with susceptible CTLA-4 gene...
  2. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  3. ncbi Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
    J Clin Endocrinol Metab 92:3162-70. 2007
    ....
  4. doi CTLA-4 +49A>G polymorphism is associated with advanced non-small cell lung cancer prognosis
    Bao Song
    Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Academy of Medical Sciences, Jinan, China
    Respiration 82:439-44. 2011
    ..The most studied +49A>G polymorphism of the CTLA-4 gene has been associated with several autoimmune diseases. However, little is known about the association between this functional polymorphism of CTLA-4 and cancer prognosis...
  5. doi Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer
    Sandra Salvi
    Department of Pathology, IRCCS AOU San Martino IST, Genoa, Italy
    Cancer Immunol Immunother 61:1463-72. 2012
    ..We presume that this effect relies on modulation of the interaction of microscopic disease with CTLA-4-ligands expressing cells leading to NSCLC cell death...
  6. pmc Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis
    Fabian Flores-Borja
    Centre for Rheumatology, Division of Medicine, Windeyer Institute of Medical Sciences, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:19396-401. 2008
    ..Our results suggest that defects in CTLA-4 could contribute to abnormal Treg function in RA and may represent a target for therapy for inducing long-lasting remission...
  7. ncbi CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism
    B Vaidya
    Department of Endocrinology, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 58:732-5. 2003
    ..Therefore, we have analysed three CTLA4 single nucleotide polymorphisms, including promoter CTLA4(-318)C/T, exon 1 CTLA4(49)A/G and intron 1 CTLA4(1822)C/T in our GD cohort from the UK...
  8. doi In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium
    Hui Qi Qu
    Department of Pediatrics, McGill University, Montreal, QC, Canada H4H 2P4
    Hum Mol Genet 19:2534-8. 2010
    ..This study replicated T1D association with at least as many of these novel loci as expected from the power of our sample size, thus supporting the validity of the new discoveries...
  9. doi Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population
    K Suwalska
    Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland
    Hum Immunol 69:193-201. 2008
    ..49A>G and CTLA-4g.*642AT(8_33) did not correlate with B-CLL. Our results are the first in the literature to report that gene polymorphism of the costimulatory molecules CTLA-4, CD28, and ICOS contributes to susceptibility to B-CLL...
  10. doi Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children
    I H S Chan
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Allergy 63:1031-9. 2008
    ..Asthma is a complex disease resulting from interactions between multiple genes and environmental factors. Study of gene-gene interactions could provide insight into the pathophysiology of asthma...
  11. doi Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population
    Edyta Pawlak
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Hum Immunol 71:195-200. 2010
    ..Our results suggest that the CTLA-4 gene is susceptibility gene to CSCC especially to well-differentiated tumor, while association between CD28 gene polymorphism and disease is restricted only to the well-differentiated CSCC...
  12. pmc Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3
    Yong Zheng
    Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 181:1683-91. 2008
    ..These data suggest that the acquisition of suppressive behavior by activated CD4(+)CD25(-) T cells requires the expression of CTLA-4, a feature that appears to be facilitated by, but is not dependent on, expression of FoxP3...
  13. pmc Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1
    Subash Babu
    National Institutes of Health International Center for Excellence in Research, India
    J Infect Dis 200:288-98. 2009
    ....
  14. pmc Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection
    John J Zaunders
    Centre for Immunology, St Vincent s Hospital, Victoria Street, Darlinghurst, NSW 2010, Australia
    J Virol 80:10162-72. 2006
    ..Taken together, the loss of HIV-specific CD4+ T cells is associated with a combination of an infection of CCR5+ CD127+ memory CD4+ T cells, possibly in GALT, and a high expression of the inhibitory receptor CTLA-4...
  15. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8))...
  16. ncbi Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
    E Chuang
    Gwen Knapp Center for Lupus and Immunology Research, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL 60637, USA
    J Immunol 159:144-51. 1997
    ..Together these data suggest that the interaction of CTLA-4 with AP50 plays an important role in regulating the cell surface expression of CTLA-4...
  17. ncbi A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells
    G Magistrelli
    Centre d Immunologie Pierre Fabre, Saint Julien en Genevois, France
    Eur J Immunol 29:3596-602. 1999
    ..These results suggest that nonstimulated T cells may constitutively produce a soluble form of CTLA-4 which may have an important role in the regulation of immune homeostasis...
  18. ncbi CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults
    Anna Cosentino
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 958:337-40. 2002
    ..028). The results of our study show that LADA is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the autoimmune origin of this form of diabetes mellitus of the adult...
  19. ncbi Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA)
    Mariela Caputo
    Laboratory of Molecular Biology, Department of Genetic and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Autoimmunity 38:277-81. 2005
    ..Several other genetic loci are needed to develop autoimmune diabetes in adult patients. Therefore, LADA may be the result of a combined minor risk loci effect in a major risk haplotype...
  20. ncbi Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer
    N Erfani
    Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
    Cancer Genet Cytogenet 165:114-20. 2006
    ..004), and the -318 CC genotype with lesser LN involvement (P = 0.007). These results suggest that CTLA4 promoter variants participate in the progression of breast cancer rather than in its initial development...
  21. ncbi Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4
    Gunduz Ahmedov
    Azerbaijan Medical University, Str K Ragimov 11, Baku, Azerbaijan Republic
    Pediatr Diabetes 7:88-93. 2006
    ..Little is known on the genetic susceptibility to type 1 diabetes mellitus (T1DM) in the nations of the former Soviet part of south-west Asia...
  22. doi A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury
    Rita Simone
    Section of Human Anatomy, Department of Experimental Medicine, University of Genova, Genova, Italy
    Int Immunol 21:1037-45. 2009
    ..In gluten-exposed patients, serum sCTLA-4 levels might provide insight about mucosal injury...
  23. ncbi Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes
    Rana J Ei Wafai
    Department of Biochemistry, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
    Saudi J Kidney Dis Transpl 22:273-81. 2011
    ..In addition, several studies have suggested that polymorphisms in the CTLA-4 gene (IDDM12) on chromosome 2q33 form part of the genetic susceptibility for type 1 diabetes...
  24. doi The functional cytotoxic T lymphocyte-associated Protein 4 49G-to-A genetic variant and risk of pancreatic cancer
    Ming Yang
    College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China
    Cancer 118:4681-6. 2012
    ..Thus, this study examined the association between functional CTLA-4 49G-to-A (49G>A) single-nucleotide polymorphism and pancreatic cancer risk...
  25. doi CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis
    Jin Xia Zhai
    Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China
    Mol Biol Rep 40:5213-23. 2013
    ..76-0.99, P = 0.04 for G vs. A) in Asian population.In summary, this meta-analysis demonstrates that the CTLA-4 promoter +49A/G and promoter -1722C/T polymorphism may confer susceptibility to SLE, especially in Asian-derived population. ..
  26. doi Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and cancer risk: a meta-analysis
    Yonggang Zhang
    Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Cancer 117:4312-24. 2011
    ..The objective of the current study was to conduct a meta-analysis investigating the association between polymorphisms in the CTLA-4 gene and the risk of cancer...
  27. ncbi Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation
    Philip de Reuver
    Department of Gastroenterology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Transplant 3:1587-94. 2003
    ..In conclusion, this pilot study suggests that liver transplant recipients homozygous for CTLA-4 + 49 G have a reduced risk of acute rejection...
  28. ncbi Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population
    Yoshiyuki Ban
    Third Department of Internal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8666, Japan
    Autoimmunity 38:151-3. 2005
    ..004, odds ratio (OR)=2.0] and AITD (P=0.03,OR=1.6) in a recessive model. These results suggested that the CTLA-4 gene is involved in the susceptibility for GD and AITD in the Japanese...
  29. ncbi CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population
    Yu Ching Weng
    Clinical Laboratory, SinLau Children Hospital, Taiwan, ROC
    Ann Clin Lab Sci 35:259-64. 2005
    ..In conclusion, we provide evidence that CT60 SNP is associated with susceptibility to GD in the Taiwanese population...
  30. doi CTLA4 gene polymorphisms are associated with chronic bronchitis
    G Zhu
    Glaxo SmithKline R and D, Research Triangle Park, NC 27709, USA
    Eur Respir J 34:598-604. 2009
    ..Haplotype analyses supported the results of single SNP analyses. Thus, CTLA4 is likely to be a genetic determinant of chronic bronchitis among COPD cases...
  31. doi CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease
    K S Park
    Department of Biology, Institute of Basic Science, Sungshin Women s University, Seoul, Korea
    Tissue Antigens 74:222-7. 2009
    Cytotoxic T lymphocyte antigen 4 (CTLA4; CD152) is a costimulatory molecule expressed on activated T cells that plays a key inhibitory role during T lymphocyte activation...
  32. pmc CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population
    Thorsten Thye
    Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    PLoS ONE 4:e6307. 2009
    ..002, P(cor) = 0.00045, P = 0.0005, respectively). This finding suggests that an increased T-cell activity associated with the CTLA4 +6230G allele contributes to pathology rather than to protection in pulmonary TB...
  33. doi The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population
    Jose F Muñoz-Valle
    Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico
    Clin Chim Acta 411:725-8. 2010
    ..The genetic contribution approaches 50-60%. The association between RA with the +49A>G CTLA-4 polymorphism in the Mexican population was investigated...
  34. pmc Association of the CTLA4 gene with Graves' disease in the Chinese Han population
    Shuang Xia Zhao
    Ruijin Hospital, State Key Laboratory of Medical Genomics, Molecular Medicine Center, Shanghai Institute of Endocrinology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 5:e9821. 2010
    ..These data suggest that the susceptibility variants of the CTLA4 gene varied between the different geographic populations with GD...
  35. doi CTLA-4 is expressed by human monocyte-derived dendritic cells and regulates their functions
    Stefania Laurent
    Department of Hematology and Oncology, University of Genoa, Genoa, Italy
    Hum Immunol 71:934-41. 2010
    ..Taken together, our data provide the first evidence that CTLA-4 receptor is expressed by human monocyte-derived mDCs upon their full activation and that it exerts immune modulatory effects...
  36. pmc CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden
    Sofia Mayans
    Medical and Clinical Genetics, Dept of Medical Biosciences, Umeå University SE 90185 Umeå, Sweden
    BMC Med Genet 8:3. 2007
    ..of polymorphisms in the CTLA-4 region to T1D and AITD and to determine whether the CT60 polymorphism affects the expression level ratio of sCTLA-4/flCTLA-4 in our population...
  37. doi Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms
    Jacek Daroszewski
    Department of Endocrinology, Diabetology, and Isotope Therapy, Medical University, ul Pasteura 4, 50 367 Wroclaw, Poland
    Eur J Endocrinol 161:787-93. 2009
    ..Graves' disease (GD) is an autoimmune disorder with genetic and environmental background. CTLA-4 is a candidate gene for thyroid autoimmunity. Increased serum levels of soluble CTLA-4 (sCTLA-4) were found in some autoimmune diseases...
  38. ncbi Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene
    Yoshino Kinjo
    Second Department of Internal Medicine, School of Medicine, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 902 0215, Japan
    J Clin Endocrinol Metab 87:2593-6. 2002
    ..0001). Group C patients did not have the AA genotype. The periods of time until remission were significantly shorter in the AA genotype. Graves' patients with the G allele need to continue ATD treatment for longer periods...
  39. ncbi The influence of the exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene on thyroid antibody production in patients with newly diagnosed Graves' disease
    Katja Zaletel
    University Medical Centre Ljubljana, Department for Nuclear Medicine, Ljubljana, Slovenia
    Thyroid 12:373-6. 2002
    ..In conclusion, our findings suggest that G allele carrying genotype of the CTLA-4 gene influences higher production of TPOAb and TgAb, and therefore, support the hypothesis that CTLA-4 gene plays a major role in TAb production...
  40. ncbi Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression
    Peng H Tan
    Department of Immunology, Division of Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 ONN, United Kingdom
    Blood 106:2936-43. 2005
    ..This gene-based strategy to knock out surface receptors is an attractive alternative to using immature dendritic cells for preventing transplant rejection and treating of autoimmune diseases...
  41. doi Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells
    Holger Hoff
    Department of Pediatrics, Otto von Guericke Universitat Magdeburg, Magdeburg, Germany
    J Immunol 182:5342-51. 2009
    ..In this study, we analyzed the role of CD152 signaling on the longevity of human CD28(null) T cells...
  42. ncbi A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus
    Lorena Fernandez-Blanco
    Hospital Clinico Universitario de Santiago Santiago, Spain
    Arthritis Rheum 50:328-9. 2004
  43. ncbi Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study
    Stefanie Eising
    Steno Diabetes Centre, Gentofte, Denmark
    Paediatr Perinat Epidemiol 21:507-17. 2007
    ..It combined genetic, immunological and demographic data to develop prediction algorithms. It also provided a resource for future studies in which new genetic markers can be included as they are identified...
  44. doi Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia
    Kek Heng Chua
    Department of Molecular Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Ann Hum Biol 37:274-80. 2010
    ..Hence, we propose that the CTLA-4 gene does not play a major role in the genetic susceptibility to the development of SLE in the Malaysian population...
  45. ncbi T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis
    Ming Chu Chang
    Departments of Internal Medicine, Surgery, Radiology, Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Clin Chem 53:1700-5. 2007
    ..We investigated possible genetic associations of CTLA4 in a Chinese population with AIP...
  46. pmc Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4
    Omar S Qureshi
    Medical Research Council MRC Centre for Immune Regulation, School of Immunity and Infection, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK
    Science 332:600-3. 2011
    ....
  47. ncbi Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence
    Xiong Biao Wang
    Immunological Research Unit, Department of Medicine, Center for Molecular Medicine CMM L8 03, Karolinska Institutet, Karolinska Hospital, S 17176, Stockholm, Sweden
    J Neuroimmunol 130:224-32. 2002
    ..The (AT)(n) polymorphism in the 3'-untranslated region contributes to decreased mRNA stability and, hence, to reduced expression of CTLA-4...
  48. pmc Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection
    Chloe L Thio
    Department of Medicine, Johns Hopkins Medical Institutions, 1503 E Jefferson Street, Baltimore, MD 21231, USA
    J Virol 78:11258-62. 2004
    ..32, P = 0.04). These data suggest that CTLA4 influences recovery from HBV infection, which is consistent with the emerging role of T regulatory cells in the pathogenesis of disease...
  49. ncbi CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population
    Antonio Petrone
    Department of Clinical Science, University of Rome La Sapienza, 00161 Rome, Italy
    Thyroid 15:232-8. 2005
    ..Inside the CTLA-4 region, CT60 appears to be the most associated polymorphism to GD, however, further studies are needed to identify the etiologic variant...
  50. ncbi Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma
    Y K Wong
    Department of Oral and Maxillofacial Surgery, Veterans General Hospital, Taichung, Taiwan
    J Oral Pathol Med 35:51-4. 2006
    ..Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4; CD152), a negative regulator of T-lymphocyte activation, plays an extremely important role in the immune tolerance and ..
  51. ncbi CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women
    Tsung Hsien Su
    Department of Gynecology and Obstetrics, Mackay Memorial Hospital, Tamshui, Taipei, Taiwan
    Carcinogenesis 28:1237-40. 2007
    ..Our results suggest that the -318 C/T variant in the promoter region of the CTLA-4 gene is associated with HPV-16-associated CSCC in Taiwanese women...
  52. doi Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation
    Tong Sun
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cancer Res 69:6011-4. 2009
    ..The requisites of CTLA-4 polymorphisms for susceptibility to cancer and response to targeted therapy are discussed in this review...
  53. ncbi The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan
    Hiroshi Ikegami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 91:1087-92. 2006
    ..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia...
  54. pmc Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort
    Tammy M Martin
    Oregon Health and Science University, Portland, OR, USA
    Mol Vis 15:208-12. 2009
    ..In this study we have analyzed SNPs in PTPN22 and CTLA-4 in patients with AAU...
  55. ncbi Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block
    Suzana M Anjos
    Department of Pediatrics, Division of Pediatrics Endocrinology, McGill University Health Center, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 89:6257-65. 2004
    ..Either the two polymorphisms define a haplotype carrying the (yet unexamined) functional variant or the -319C>T contributes to the genetic association independently, a possibility suggested by the functional evidence we present...
  56. pmc Association of CT60 cytotoxic T lymphocyte antigen-4 gene polymorphism with thyroid autoantibody production in patients with Hashimoto's and postpartum thyroiditis
    K Zaletel
    Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia
    Clin Exp Immunol 161:41-7. 2010
    ..In PPT, the genotype also seems to influence thyroid function, as patients with the polymorphous allele are more prone to develop hypothyroid form of PPT...
  57. ncbi Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
    H T Leung
    Bristol Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121, USA
    J Biol Chem 270:25107-14. 1995
    ..Thus, the subcellular localization of CTLA-4 is controlled by a tyrosine-containing motif within its cytoplasmic domain. Contained within this motif is a binding site for SH2 domains of the p85 subunit of phosphatidylinositol 3-kinase...
  58. doi CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese
    Peng Qi
    Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China
    Int J Colorectal Dis 25:39-45. 2010
    ..Our aim was to investigate the association between this genetic variant and the risk as well as progression of colorectal cancer in Chinese...
  59. ncbi Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells
    Daniele Saverino
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    J Immunol 168:207-15. 2002
    ..we have investigated the effects of the CD85/leukocyte Ig-like receptor (LIR)-1/Ig-like transcript (ILT) 2 and of CD152 (CTLA-4) inhibitory receptors on the modulation of cell-mediated immune responses to specific Ags, both at the ..
  60. pmc Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling
    Xuewu Zhang
    Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 100:2586-91. 2003
    ....
  61. pmc Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    Giao Q Phan
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:8372-7. 2003
    ..This study establishes CTLA-4 as an important molecule regulating tolerance to "self" antigens in humans and suggests a role for CTLA-4 blockade in breaking tolerance to human cancer antigens for cancer immunotherapy...
  62. ncbi CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
    K Harper
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Marseille, France
    J Immunol 147:1037-44. 1991
    ....
  63. ncbi Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
    M P Marron
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, USA
    Hum Mol Genet 6:1275-82. 1997
    ..002) and the Korean population (P = 0.03). These results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4.
  64. ncbi Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population
    R M McCormack
    Department of Medical Genetics, The Queen s University of Belfast, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, Northern Ireland
    Genes Immun 2:233-5. 2001
    ..02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population...
  65. pmc Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes
    Jean Claude Ongagna
    Centre Européen d Etude du Diabète Hĵpitaux Universitaires de Strasbourg
    Int J Exp Diabetes Res 3:1-9. 2002
    ..There is polymorphism at position 49 in exon 1 of the CTLA-4 gene, providing an A-G exchange. Moreover, we assessed the CTLA-4 49 (Thr/Ala) polymorphism in diabetic patients and first-degree relatives as compared to control subjects...
  66. pmc Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
    Peter J Darlington
    The Biotherapeutics and Transplantation and Immunobiology Groups, The John P Robarts Research Institute, and The Departments of Microbiology and Immunology, and Medicine, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Exp Med 195:1337-47. 2002
    ..These data demonstrate that CTLA-4 within lipid rafts migrates to the IS where it can potentially form lattice structures and inhibit T cell activation...
  67. ncbi Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis
    Anne Barton
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:748-52. 2004
    ..The aim of this study was to investigate the association of the CTLA-4 polymorphism with RA...
  68. ncbi Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population
    Hua Liang
    Second Department of Internal Medicine, Kanazawa University, Ishikawa, Japan
    Endocrine 25:105-9. 2004
    ....
  69. ncbi Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides -- cutaneous T cell lymphoma
    Henry K Wong
    Department of Dermatology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Invest Dermatol 126:212-9. 2006
    ..These findings reveal an abnormal regulation of CTLA-4 expression in MF and show that PBMCs from patients with MF have properties that are divergent from those of normal T cells...
  70. ncbi Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjögren's syndrome
    Sarah Downie-Doyle
    Hanson Institute and The Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Arthritis Rheum 54:2434-40. 2006
    ..Using these 2 polymorphisms as markers, we investigated possible genetic associations of CTLA4 in Australian patients with primary Sjögren's syndrome...
  71. ncbi Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1079:251-6. 2006
    ..The frequency of the CT60 GG genotype did not appear to be affected by either the VDR gene Bsm I large B polymorphism or HLA DR9...
  72. ncbi [Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer]
    Heng Li
    Department of Immunology, Harbin Medical University, Harbin 150081, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24:282-4. 2008
    ..To investigate the association between the CTLA-4 promoter-1722(T/C) and 3' untranslated region CT60(G/A) polymorphisms and the risk of breast cancer in Han women of northeast China...
  73. doi CTLA-4 +49A/G polymorphism is associated with Behçet's disease in a Tunisian population
    I Ben Dhifallah
    Homeostasis and Cell Dysfunction Unit Research 99 UR 08 40, Medicine University of Tunis, Tunisia
    Tissue Antigens 73:213-7. 2009
    ..Our results show a gene dose effect of the A allele on the BD. The A allele exerts a stronger effect on disease susceptibility in males compared with females...
  74. doi CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression
    Z Chen
    Department of Gastroenterology, Wuhan University Zhongnan Hospital, PR China
    Genes Immun 11:573-83. 2010
    ..This is likely from decreased expressions of sCTLA4 mRNA and sCTLA4 protein. Our study suggests that CTLA4 has an important role in susceptibility for UC in Central China...
  75. doi [Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer]
    Li Jiang
    Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:313-7. 2011
    ..To evaluate the association between single nucleotide polymorphisms (SNPs) of cytotoxic T-lymphocyte-associated protein 4 (CTLA4) gene and susceptibility to cervical cancer...
  76. doi Association between the CTLA-4 +49 A/G polymorphism and susceptibility to rheumatoid arthritis: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, 126 1, Anam Dong 5 Ga, Seongbuk gu, Seoul, 136 705, Korea
    Mol Biol Rep 39:5599-605. 2012
    ..This meta-analysis demonstrates that the CTLA-4 +49 A/G polymorphism confers susceptibility to RA in Asians, but not in Caucasians...
  77. doi Polymorphisms in the CTLA-4 gene and rheumatoid arthritis susceptibility: a meta-analysis
    Xiaobo Li
    The 452nd Military Hospital of China, Chengdu, Sichuan, 610041, China
    J Clin Immunol 32:530-9. 2012
    ..The aim of this study is to comprehensively evaluate the genetic risks of +49A/G and CT60 polymorphisms in the CTLA-4 gene for RA...
  78. pmc A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression
    Rita Simone
    Department of Experimental Medicine Section of Human Anatomy, University of Genova, Genova, Italy
    PLoS ONE 7:e44654. 2012
    ..This suggests a possible role of this soluble molecule as a marker of progression or severity of the neoplastic disease...
  79. ncbi [Correlation between CTLA-4 gene polymorphism and systemic lupus erythematosus: a meta-analysis]
    Shui Lian Chen
    Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28:1320-3. 2012
    ..To determine the correlation between CTLA-4 gene polymorphism and systemic lupus erythematosus (SLE) susceptibility...
  80. pmc Overexpression and secretion of the soluble CTLA-4 splice variant in various autoimmune diseases and in cases with overlapping autoimmunity
    Suad Alfadhli
    Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait, Kuwait
    Genet Test Mol Biomarkers 17:336-41. 2013
    ..mCTLA-4 and sCTLA-4 mRNA expression were analyzed using quantitative real time-PCR. The enzyme-linked immunosorbent assay (ELISA) was used to screen sCTLA-4 in all subjects' sera...
  81. doi Association between the cytotoxic T-lymphocyte antigen 4 +49A/G polymorphism and bladder cancer risk
    Lei Wang
    Department of Urology, Zhengzhou Central Hospital, Zhengzhou University, Tongbai Road 195, Zhengzhou, 450000, China
    Tumour Biol 35:1139-42. 2014
    ..This is the first study to highlight the significant association between CTLA-4 +49A/G polymorphism and bladder cancer risk. Additional studies are needed to confirm this finding...
  82. ncbi Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians
    A Milicic
    Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Tissue Antigens 58:50-4. 2001
    ..We conclude that, although the importance of the B7-CTLA-4 interaction in the development of RA can not be excluded, the CTLA-4 gene is unlikely to be a predisposing factor to this disease...
  83. ncbi HLA-DQB1 CAR1/CAR2, TNFa IR2/IR4 and CTLA-4 polymorphisms in Tunisian patients with rheumatoid arthritis and Sjögren's syndrome
    H Hadj Kacem
    Laboratoire de Génétique Moléculaire Humaine, Faculte de Medecine, Sfax, Tunisia
    Rheumatology (Oxford) 40:1370-4. 2001
    ..To evaluate the contribution of HLA class II region and the CTLA-4 gene in genetic susceptibility to rheumatoid arthritis (RA) and Sjögren's syndrome (SS) in the Tunisian population...
  84. ncbi Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom
    Ratnasingam Nithiyananthan
    Division of Medical Sciences, University of Birmingham, Birmingham Heartlands Hospital, United Kingdom
    Thyroid 12:3-6. 2002
    ..8.8% and 50% vs. 46% respectively; chi2 = 11.7, p = 0.003). These results suggest that the CTLA-4 gene region on chromosome 2q33 is a susceptibility locus for autoimmune hypothyroidism in the United Kingdom...
  85. ncbi The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children
    O Cinek
    2nd Department of Paediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    Eur J Immunogenet 29:219-22. 2002
    ..This may be another piece of evidence against the +49 A/G transition as the aetiological polymorphism within the CTLA4 gene...
  86. ncbi A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes
    J P Wood
    Department of Internal Medicine I, Division of Endocrinology, University Hospital Frankfurt, Frankfurt am Main, Germany
    Eur J Immunogenet 29:347-9. 2002
    Type 1 diabetes mellitus is an autoimmune disease with a strong genetic background. The CTLA4 gene region (IDDM12) has been implicated in genetic susceptibility to type 1 diabetes by genome scanning and both family- and population-based ..
  87. ncbi Association of CTLA-4 variation with type I diabetes in Filipinos
    William Klitz
    School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Immunogenetics 54:310-3. 2002
    ..6, P=0.001), demonstrating that non- HLA loci, acting in concert with HLA, can play potent roles in modifying susceptibility to TID...
  88. ncbi No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea
    Scand J Rheumatol 31:266-70. 2002
    ..Our data show that the polymorphisms within the CTLA-4 exon 1(+49) and promoter(-318) genes are not associated with susceptibility to RA and its clinical/serological manifestations in the Korean population...
  89. ncbi CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese
    Yun Ma
    Department of Endocrinology, The First Affiliated Hospital, Lanzhou Medical College, Lanzhou, China
    Chin Med J (Engl) 115:1248-50. 2002
    ..To investigate the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene A/G polymorphism with susceptibility to diabetes mellitus in Han Chinese...
  90. ncbi Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells
    Karen I Mead
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:4803-11. 2005
    ..Taken together, these data suggest that CTLA-4 may be stored in a specialized compartment in regulatory T cells that can be triggered rapidly for deployment to the PM in a phospholipase D- and ADP ribosylation factor-1-dependent manner...
  91. ncbi Haplotype tagging efficiency in worldwide populations in CTLA4 gene
    A Ramírez-Soriano
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Barcelona, Catalonia 08003, Spain
    Genes Immun 6:646-57. 2005
    ..A continent-specific set of haplotype tagging SNPs has been designed to be used for future association studies. These are portable among populations, although their efficiency might vary depending on the population haplotype spectrum...
  92. ncbi Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians
    V Baniasadi
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    Tissue Antigens 67:383-9. 2006
    ..The results of the present study indicate that the presence of G allele at -1661 locus at the CTLA-4 gene (IDDM12 locus) is associated with increased susceptibility to type 1 diabetes in North Indians, whereas A allele is ..
  93. ncbi [Association of CTLA-4 + 49A/G and CT60 gene polymorphism with type 1 diabetes and thyroid autoimmunity]
    Ping Jin
    Diabetes Center, Metabolic Syndrome Research Center, Institute of Metabolism and Endocrinology, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Zhonghua Yi Xue Za Zhi 89:1246-9. 2009
    ..To investigate the association of CTLA-4 + 49A/G and CT60 gene polymorphisms with type 1 diabetes (T1DM) and thyroid autoimmunity. Subjects Three hundred thirty-two T1DM patients and 476 controls were recruited in the study...
  94. pmc A screen for endocytic motifs
    Patrycja Kozik
    University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 0XY, UK
    Traffic 11:843-55. 2010
    ..Thus, the repertoire of endocytic motifs is more extensive than the three well-characterized sorting signals...
  95. doi CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease
    Ho Chang Kuo
    Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    J Clin Immunol 31:240-4. 2011
    ..This study examined the correlation of CTLA-4 gene polymorphisms in KD with and without coronary artery lesions (CAL)...
  96. doi Association of CTLA-4 (+49A/G) gene polymorphism with type 1 diabetes mellitus in Egyptian children
    Youssef M Mosaad
    Clinical Immunology Unit, Clinical Pathology Department, Mansoura, Egypt
    Immunol Invest 41:28-37. 2012
    ..To investigate the distribution of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (+49 A/G) gene variants and the association of these variants with the clinical and laboratory findings in Egyptian children with Type-1 Diabetes (T1D)...
  97. doi Cytotoxic T-lymphocyte antigen 4 gene +49A/G polymorphism significantly associated with susceptibility to primary biliary cirrhosis: a meta-analysis
    Rui Rui Chen
    Institute of Digestive Diseases, Xijing Hospital, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi an, Shaanxi Province, China
    J Dig Dis 12:428-35. 2011
    ..To evaluate comprehensively the association of cytotoxic T-lymphocyte antigen 4 (CTLA-4) +49A/G polymorphism with susceptibility to primary biliary cirrhosis (PBC)...
  98. doi Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers
    Michelle C Rocha
    Department of Pharmacology and Hemocenter, Faculty of Medical Sciences, FCM, State University of Campinas UNICAMP, Campinas, SP, Brazil
    Int J Hyg Environ Health 215:562-9. 2012
    ..Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsiveness, ..
  99. doi CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1 Anam dong 5 ga, Seongbuk gu, Seoul 136 705, Korea
    Mol Biol Rep 39:9041-5. 2012
    ..No association was found between BD and the CTLA-4 -318 C/T or CT60 A/G polymorphisms. This meta-analysis showed that no association was found between CTLA-4 +49 A/G, -318 C/T or CT60 A/G polymorphisms and BD...
  100. doi Association of the CTLA-4 +49A/G polymorphism with rheumatoid arthritis in Chinese Han population
    Ming Jie Tang
    Orthopaedics Department, Shanghai Sixth People s Hospital, Shanghai Jiao Tong University, No 600, Yishan Road, Shanghai, 200233, People s Republic of China
    Mol Biol Rep 40:2627-31. 2013
    ..Our results suggested that the CTLA-4 gene might contribute to the pathogenesis of RA, and the +49A/G polymorphism of this gene was a risk factor associated with increased RA susceptibility in Chinese Han population...
  101. doi Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children
    Iván Balic
    Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute INTA, University of Chile, Santiago, Chile
    Hum Immunol 70:116-20. 2009
    ..However, the presence of a GG genotype or G allele dosage was associated with a younger age of onset, higher prevalence of ketoacidosis at the moment of diagnosis and positive anti-GAD65 serum autoantibodies...

Research Grants70

  1. CRAIG LEE SLINGLUFF; Fiscal Year: 2014
    ....
  2. IL-2 scintigraphy as a guide to cancer immunotherapy
    SVETOMIR NENAD MARKOVIC; Fiscal Year: 2013
    ....
  3. Michail Sitkovsky; Fiscal Year: 2016
    ..This, in turn, will provide superior design of anti-hypoxia-A2AR-adenosinergic clinical protocols. ..
  4. Bin Zhang; Fiscal Year: 2015
    ....
  5. Robert H Vonderheide; Fiscal Year: 2015
    ....
  6. Glenn Dranoff; Fiscal Year: 2014
    ..Work in this project will clarify the ways in which MFG-E8 blockade accomplishes melanoma killing, which in turn should support the development of MFG-E8 targeted treatments for melanoma patients. ..
  7. Walter J Storkus; Fiscal Year: 2016
    ....
  8. KARL D WITTRUP; Fiscal Year: 2016
    ..We will also test for protective immunity and antigen spreading using syngeneic tumors lacking the antigen targeted by the bsAb (CEA). ..
  9. Combination immunotherapies for the treatment of melanoma
    Michael W Fanger; Fiscal Year: 2013
    ....
  10. Antoni Ribas; Fiscal Year: 2015
    ..However, application of the new immune monitoring tools yielded clear insights that strongly correlated with clinical outcomes, and those results have informed a clear direction for designing the proposed program. ..
  11. LI LILY WANG; Fiscal Year: 2016
    ....
  12. Defining the Importance of Immunity to NY-ESO-1 in Melanoma Therapy and Prognosis
    Jedd D Wolchok; Fiscal Year: 2010
    ..Validation of this observation in the large population of patients treated on a randomized trial in the adjuvant setting will further inform us of the importance of NY-ESO-1 immunity. ..
  13. Jeffrey S Weber; Fiscal Year: 2016
    ....
  14. Maryann E Mikucki; Fiscal Year: 2015
    ....
  15. Non-Human Primate Model of Gluten-Sensitive Enteropathy
    Karol Sestak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In humans, gluten-sensitive enteropathy (GSE) is typically found in individuals genetically predisposed to celiac disease (CD), and in rhesus monkeys as well as in humans it can be induced by a gluten-..
  16. Brian Till; Fiscal Year: 2016
    ....
  17. Marian J Rewers; Fiscal Year: 2016
    ..These studies should improve our ability to design trials for the prevention of Type 1 diabetes as we better define the natural history of the disease. ..
  18. Analyzing The Joint Susceptibility Genes for Autoimmune Thyroiditis and Diabetes
    Yaron Tomer; Fiscal Year: 2012
    ..the mechanisms causing the strong association between thyroid autoimmunity and type1 diabetes will allow us not only disease predictions within families, but also to develop rational, mechanism-based, treatment and prevention strategies ..
  19. STUART KEITH CALDERWOOD; Fiscal Year: 2016
    ..We will further determine whether vaccine design can be manipulated to give selective destruction of tumor initiating cells and radiation resistant cells that accumulate in fractionated radiation therapy. ..
  20. Zhibin Chen; Fiscal Year: 2014
    ..This study aims to provide novel and in-depth knowledge on how a master inhibitor of adaptive immunity suppresses initiation of tumorigenesis, with a long-term goal to identify strategies for gastric cancer prevention. ..
  21. New T Cell Coinhibitory Pathway and Type 1 Diabetes
    Xingxing Zang; Fiscal Year: 2010
    ..abstract_text> ..
  22. Allergies, Genetic Susceptibility and Adult Glioma Risk
    Dominique S Michaud; Fiscal Year: 2011
    ..Improving our understanding of the etiology of gliomas will provide opportunities for treatment options or prevention of this deadly cancer. ..
  23. Tilting the balance in cancer immunotherapy and autoimmunity
    Wei Zen Wei; Fiscal Year: 2010
    ..Establish a vaccination regimen to inhibit spontaneous tumorigenesis and tumor metastasis, and 3. Amplify the immunogenicity of a growing tumor by in situ transfection with TetC DNA. ..
  24. WALTER TSONG LEE; Fiscal Year: 2015
    ..Furthermore, this VA-CDA-2 will allow Dr. Lee to establish a VA-based career and enable him to mature into an independently funded surgeon scientist. ..
  25. Vaccination with IL-15 DC to Generate Melanoma-specific Protective Memory T Cells
    Anna Karolina Palucka; Fiscal Year: 2013
    ..Current therapies have the potential to improve outcome in a fraction of patients but are associated with considerable toxicity. Vaccination with melanoma antigen-loaded dendritic cells (DCs) could improve outcomes without toxicity. ..
  26. David H Munn; Fiscal Year: 2016
    ....
  27. Ronald P Dematteo; Fiscal Year: 2016
    ..In Aim 3, we will define how CTLA-4 blockade enhances the anti-tumor effects of imatinib in GIST. Our findings will advance our understanding of GIST and may lead to a novel clinical trial using combined molecular and immune therapy. ..
  28. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..The purpose of this project is to evaluate the effect of HIV infection on the function of regulatory T cells, using the feline immunodeficiency virus (FIV)-infected cat to model maternal-fetal infection and compromised pregnancy. ..
  29. Immune Tolerance and Autoimmunity
    Abul K Abbas; Fiscal Year: 2010
    ..The results are not only of biological significance, but will also provide valuable leads for strategies to induce tolerance as a therapeutic modality. ..
  30. Padmanee Sharma; Fiscal Year: 2016
    ....
  31. Darrell J Irvine; Fiscal Year: 2016
    ....
  32. B7-based, CD28 or CTLA-4-specific agonists and antagonists for tolerance inductio
    Roland K Strong; Fiscal Year: 2013
    ..CD28 magnifies the effects of TCR signaling and enhances both cell cycle progression and T cell survival;CTLA-4 (CD152) provides opposing inhibitory signals. CD28 and CTLA-4 bind the shared, related ligands B7.1 (CD80) and B7...
  33. Anti-CTLA-4 enhances the effects of imatinib in gastrointestinal stromal tumor
    Teresa Kim; Fiscal Year: 2012
    ..We expect that our work will not only improve the lives of patients with these tumors, but also be relevant to other cancers in which targeted molecular therapy is used. ..
  34. Li Huang; Fiscal Year: 2014
    ..Therefore, PD-1 is a valid drug target, and accomplishing the proposed studies will lay a foundation for further development of this class of small molecules as immunotherapeutic drug candidates for potential HIV-1 eradication. ..
  35. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2013
    ..abstract_text> ..
  36. PD-1 Abrogation and Immunity in Melanoma
    Jeffrey S Weber; Fiscal Year: 2012
    ....
  37. JEFFREY VICTOR RAVETCH; Fiscal Year: 2015
    ....
  38. To Understand/Augment OX40-mediated Tumor Immunotherapy
    Andrew D Weinberg; Fiscal Year: 2013
    ....
  39. RADU VIRGIL STAN; Fiscal Year: 2014
    ..The data we expect to obtain are relevant to the pathophysiology of cancer in general and will establish PV1 as a novel target for cancer treatment. ..
  40. Prostate Cancer Immunotherapy
    Lawrence Fong; Fiscal Year: 2013
    ..Alternatively, we may define an immune response signature that may predict which patients might respond to this immunotherapeutic approach. ..
  41. Role of Macrophage Regulatory Cells (Mac-regs) in Immune Regulation
    Joseph Lustgarten; Fiscal Year: 2010
    ..abstract_text> ..
  42. ANDREW ANDREW FUTREAL; Fiscal Year: 2015
    ....
  43. Regulation of Foxp3 Function
    Andrew D Wells; Fiscal Year: 2012
    ....
  44. The quantitative biology of CTLA4 splice variants in T1D
    Zhibin Chen; Fiscal Year: 2009
    ..Variations of the CTLA4 gene are associated with a higher risk of developing this disease. An understanding of the functional impact of CTLA4 genetic variations will help find new therapeutic targets for type 1 diabetes. ..
  45. B7/CD28/CTLA-4 COSTIMULATION IN PATHOGENESIS OF R-EAE
    Stephen Miller; Fiscal Year: 2003
    ....
  46. Gene modified vaccine in combination with Ipilimumab for advanced pancreatic canc
    Daniel Laheru; Fiscal Year: 2009
    ..Ipilimumab is an agent that may enhance the body's immune response to the vaccine and ultimately to the cancer. ..
  47. MERVYN N WEITZMANN; Fiscal Year: 2016
    ....
  48. SCOTT MATTHEW WILLIAMS; Fiscal Year: 2016
    ..of expert knowledge about biochemical pathways, gene function and experimental results using gene set enrichment (GSE) methods...
  49. Production of animal models to define how CTLA-4 impacts to T1D susceptibility
    Joonsoo Kang; Fiscal Year: 2010
    ..This application will generate new mouse models to determine the relationship between CTLA-4 and other factors that regulate T1D progression so that more rationale therapies designed to target CTLA-4 to treat T1D can be formulated. ..
  50. Michael Demetriou; Fiscal Year: 2014
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  51. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..These studies will establish a novel approach for tolerance with human T cells in a clinically relevant model, and will continue the translation of this project forward to the clinic as a potential therapy for multiple sclerosis. ..
  52. Human Autoimmunity and Genetic Defects in N-Glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..Metabolically supplementing the pathway with a simple sugar suppresses immune hyperactivity and development of autoimmunity, suggesting human disease may be treated/prevented with metabolic therapy. ..
  53. Vince N Montes; Fiscal Year: 2014
    ..The research environment at the University of Washington is excellent for a budding physician- scientist, and I plan on taking absolute advantage of the resources available. (End of Abstract) ..
  54. SUSCEPTIBILITY GENES IN AUTOIMMUNE THYROID DISEASE
    TERRY FRANCIS DAVIES; Fiscal Year: 2013
    ..The benefit to the individual and society is potentially great in alleviating suffering due to the more severe forms of this thyroid disorder, especially Graves'ophthalmopathy. ..
  55. Genetic Basis for susceptibility to EAE
    Vijay K Kuchroo; Fiscal Year: 2011
    ..abstract_text> ..
  56. Jenny T Mao; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Ample preclinical data suggests that grape seed extract (GSE) possesses anticarcinogenic properties. Grape seed contains high levels of polyphenols, including proanthocyanidins...
  57. Drew M Pardoll; Fiscal Year: 2014
    ....
  58. TIM-3: Galectin-9: A Novel Regulatory Pathway of Alloimmune Activation
    Nader Najafian; Fiscal Year: 2011
    ..Utilization of unique tools combined with close collaboration of the PI with a team of renowned experts will assure the successful completion of this proposal. ..
  59. ROBERT JON SOIFFER; Fiscal Year: 2016
    ..PROJECT/PERFORMANGE SITE(S) (if additional space is needed, use Project/Perfonnance Site Fonnat Page) ..
  60. David A Hafler; Fiscal Year: 2016
    ....
  61. Screening for inhibitors of the T cell Tec kinase, ltk
    Joonsoo Kang; Fiscal Year: 2010
    ..This proposal aims to develop a screen for inhibitors of this enzyme, which could be used to prevent the onset of autoimmune processes in susceptible individuals and to treat and cure patients with these diseases. ..
  62. Rapid, Point-of-Care Diagnosis of Neonatal Sepsis
    GREGORY SOMMER; Fiscal Year: 2013
    ..The company anticipates penetration into the estimated $1.5 billion global clinical neonatal and pediatric monitoring market within 4 years. ..
  63. Isolation of Genetic Suppressor Elements Against Hepatitis C Virus
    Zhilei Chen; Fiscal Year: 2010
    ..Future studies originating from the identified GSEs are expected to reveal the molecular basis of the anti-HCV GSE activity, thus providing new leads for anti-HCV drug development...
  64. Multiple Sclerosis and Genetic Defects in N-Glycosylation
    Michael Demetriou; Fiscal Year: 2009
    ..Specific Aim 3 will associate genetic variants identified in Specific Aim 1 and/or 2 in large Multiple Sclerosis co-horts. ..
  65. DERMATITIS HERPETIFORMIS AND THE MUCOSAL IMMUNE RESPONSE
    Russell Hall; Fiscal Year: 2005
    ..the presence of cutaneous IgA deposits and an associated, almost always asymptomatic, gluten sensitive enteropathy (GSE)...
  66. LOSS OF TH1 IMMUNE FUNCTION IN FIV-INFECTED CATS
    Mary Tompkins; Fiscal Year: 2004
    ..The latter studies will determine whether B7-CTLA4 signaling mediates its activity by affecting gene transcription. ..
  67. Anti-CTLA-4 Monoclonal Antibody Therapy for Lymphoma
    John Timmerman; Fiscal Year: 2005
    ..abstract_text> ..
  68. T cell costimulation and regulation in myocarditis
    Andrew Lichtman; Fiscal Year: 2006
    ..The focus is on newly characterized T cell regulatory pathways, which are potential targets for immunotherapy of myocarditis and other autoimmune diseases. ..
  69. CTLA-4 Blockade in Allo Stem Cell Transplantation
    Edward Ball; Fiscal Year: 2005
    ..abstract_text> ..
  70. Gluten Sensitivity in the Old Order Amish
    Daniel McBride; Fiscal Year: 2005
    Gluten-sensitive enteropathy (GSE; VIM 607202) or celiac disease (CD; MIM 212750) has been well recognized as a public health concern for some time in Europe...