CSTB

Summary

Gene Symbol: CSTB
Description: cystatin B
Alias: CPI-B, CST6, EPM1, EPM1A, PME, STFB, ULD, cystatin-B, cystatin B (stefin B), liver thiol proteinase inhibitor
Species: human

Top Publications

  1. pmc Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages
    C Luciano-Montalvo
    Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, Puerto Rico
    Placenta 29:1016-23. 2008
  2. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
  3. ncbi Cathepsin D inactivates cysteine proteinase inhibitors, cystatins
    B Lenarcic
    Department of Biochemistry, J Stefan Institute, Ljubljana, Yugoslavia
    Biochem Biophys Res Commun 154:765-72. 1988
  4. ncbi Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)
    L A Pennacchio
    Department of Genetics, Stanford University School of Medicine, Standford, CA 94305, USA
    Science 271:1731-4. 1996
  5. ncbi Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity
    Gregor Anderluh
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Slovenia
    FEBS J 272:3042-51. 2005
  6. ncbi Cystatin B: mutation detection, alternative splicing and expression in progressive myclonus epilepsy of Unverricht-Lundborg type (EPM1) patients
    Tarja Joensuu
    Department of Medical Genetics and Neuroscience Center, Folkhalsan Institute of Genetics, Biomedicum Helsinki, University of Helsinki, Finland
    Eur J Hum Genet 15:185-93. 2007
  7. doi Interaction with model membranes and pore formation by human stefin B: studying the native and prefibrillar states
    Sabina Rabzelj
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 275:2455-66. 2008
  8. pmc Stefin B interacts with histones and cathepsin L in the nucleus
    Slavko Ceru
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana SI 1000, Slovenia
    J Biol Chem 285:10078-86. 2010
  9. ncbi Unstable insertion in the 5' flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1
    R G Lafreniere
    Centre for Research in Neuroscience, McGill Univ, Montreal, Quebec, Canada
    Nat Genet 15:298-302. 1997
  10. ncbi Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)
    J Kos
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia
    Oncol Rep 5:1349-61. 1998

Research Grants

Detail Information

Publications309 found, 100 shown here

  1. pmc Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages
    C Luciano-Montalvo
    Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, Puerto Rico
    Placenta 29:1016-23. 2008
    ..an m/z of 11,100, which was significantly lower in uninfected and HIV-infected PM than in MDM, was identified as cystatin B (CSTB). Studies of siRNA against CSTB treatment in MDM associated its expression with HIV replication...
  2. ncbi The cystatins: protein inhibitors of cysteine proteinases
    V Turk
    Department of Biochemistry, Jozef Stefan Institute, Ljubljana, Slovenia, Yugoslavia
    FEBS Lett 285:213-9. 1991
    ....
  3. ncbi Cathepsin D inactivates cysteine proteinase inhibitors, cystatins
    B Lenarcic
    Department of Biochemistry, J Stefan Institute, Ljubljana, Yugoslavia
    Biochem Biophys Res Commun 154:765-72. 1988
    ....
  4. ncbi Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1)
    L A Pennacchio
    Department of Genetics, Stanford University School of Medicine, Standford, CA 94305, USA
    Science 271:1731-4. 1996
    ..3. The gene encoding cystatin B was shown to be localized to this region, and levels of messenger RNA encoded by this gene were found to be ..
  5. ncbi Interaction of human stefin B in the prefibrillar oligomeric form with membranes. Correlation with cellular toxicity
    Gregor Anderluh
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Slovenia
    FEBS J 272:3042-51. 2005
    ..This study is aimed to contribute to the general model of cellular toxicity induced by prefibrillar oligomers of amyloidogenic proteins, not necessarily involved in pathology...
  6. ncbi Cystatin B: mutation detection, alternative splicing and expression in progressive myclonus epilepsy of Unverricht-Lundborg type (EPM1) patients
    Tarja Joensuu
    Department of Medical Genetics and Neuroscience Center, Folkhalsan Institute of Genetics, Biomedicum Helsinki, University of Helsinki, Finland
    Eur J Hum Genet 15:185-93. 2007
    ..Unverricht-Lundborg type (EPM1) is an autosomal recessive neurodegenerative disorder caused by mutations in the cystatin B gene (CSTB) that encodes an inhibitor of several lysosomal cathepsins...
  7. doi Interaction with model membranes and pore formation by human stefin B: studying the native and prefibrillar states
    Sabina Rabzelj
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    FEBS J 275:2455-66. 2008
    ..Similarities to other amyloidogenic proteins and the possible physiological implications of our findings are discussed...
  8. pmc Stefin B interacts with histones and cathepsin L in the nucleus
    Slavko Ceru
    Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana SI 1000, Slovenia
    J Biol Chem 285:10078-86. 2010
    Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases localized in the nucleus and the cytosol...
  9. ncbi Unstable insertion in the 5' flanking region of the cystatin B gene is the most common mutation in progressive myoclonus epilepsy type 1, EPM1
    R G Lafreniere
    Centre for Research in Neuroscience, McGill Univ, Montreal, Quebec, Canada
    Nat Genet 15:298-302. 1997
    ..Recently, two mutations in the cystatin B gene (also known as stefin B, STFB) mapping to 21q22...
  10. ncbi Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review)
    J Kos
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, 1000 Ljubljana, Slovenia
    Oncol Rep 5:1349-61. 1998
    ..Their application for diagnosis, follow-up and the anticancer therapy has also been proposed...
  11. ncbi Cystatin B and its EPM1 mutants are polymeric and aggregate prone in vivo
    Elena Cipollini
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Biochim Biophys Acta 1783:312-22. 2008
    Progressive myoclonus epilepsy type 1 (EPM1) is a neurodegenerative disease correlating with mutations of the cystatin B gene. Cystatin B is described as a monomeric protein with antiprotease function...
  12. doi The mechanism of amyloid-fibril formation by stefin B: temperature and protein concentration dependence of the rates
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, 1000 Ljubljana, Slovenia
    Proteins 74:425-36. 2009
    ..We have extended previous studies of the kinetics of amyloid-fibril formation by human stefin B (cystatin B) and some of its mutants, and proposed an improved model for the reaction...
  13. pmc Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages
    C Luciano-Montalvo
    Department of Microbiology and Medical Zoology, University of Puerto Rico, San Juan, PR 00935
    Placenta 30:464-7. 2009
    ..This is the first report to demonstrate that cystatin B interacts with STAT-1 and that the levels of STAT-1 tyrosine phosphorylation (but not serine phosphorylation) ..
  14. pmc Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells
    Katja Skerget
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, Slovenia
    J Biol Chem 285:3201-10. 2010
    ..in Alzheimer disease and in neuroprotection in general, we studied the interaction between human stefin B (cystatin B) and amyloid-beta-(1-40) peptide (Abeta)...
  15. doi Intracellular aggregation of human stefin B: confocal and electron microscopy study
    Slavko Ceru
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biol Cell 102:319-34. 2010
    ..Mutations in the CSTB (cystatin B) gene [StB (stefin B)] cause EPM1 (progressive myoclonus epilepsy of type 1), an epilepsy syndrome with features ..
  16. ncbi [Myoclonic epilepsies in infancy]
    R Palencia
    , Facultad de Medicina, Hospital Universitario, Valladolid,
    Rev Neurol 30:S15-24. 2000
    ..reflex myoclonic epilepsy, as well as progressive myoclonic epilepsies, among which progressive myoclonic epilepsy (PME) type 1 (Unverricht-Lundborg's disease) and PME2 (Lafora type) are prominent, whereas other entities, such as those ..
  17. ncbi [A case of degenerative type of progressive myoclonus epilepsy]
    A Tateno
    Department of Pediatrics, Sakura Hospital, Toho University, School of Medicine, Chiba
    No To Hattatsu 25:81-6. 1993
    This report describes a patient with degenerative type of progressive myoclonus epilepsy (PME), who showed slowly progressive deterioration of the central nervous system; intellectual impairment, dysarthria, and involuntary movements, ..
  18. ncbi [A case of non-photosensitive, self-induced epileptic seizures with pacygyria]
    H Nagai
    Department of Pediatrics, Maizuru Hospital of Self Defense Force, Kyoto
    No To Hattatsu 30:417-22. 1998
    ..Treatment with valporate and zonisamide was effective in reducing the seizures. The findings of our case imply the pathogenesis of self-induced seizures and the relationship between PME and neuronal migration disorders.
  19. ncbi [Progressive myoclonic epilepsy: clinical characteristics of 18 patients]
    A Vistorte
    , , La Habana, Cuba
    Rev Neurol 29:102-4. 1999
    INTRODUCTION: The term progressive myoclonic epilepsy (PME) includes a groups of heterogeneous conditions, with genetic causes, characterized by having different types of seizures, basically myoclonic, and other neurological findings due ..
  20. doi Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all
    Antonio V Delgado-Escueta
    Epilepsy Genetics Genomics Laboratories, VA Greater Los Angeles Healthcare System, David Geffen School of Medicine at UCLA, West Los Angeles, California 90073, USA
    Epilepsia 49:13-24. 2008
    ..protein phosphatase) and malin (ubiquitin E3 ligase) in Lafora progressive myoclonic epilepsy (PME); and (3) cystatin B in Unverricht-Lundborg type of PME...
  21. ncbi [Progressive study of EEG and evoked potentials in Lafora disease]
    P Orizaola
    , , Santander,
    Rev Neurol 27:81-5. 1998
    ..study of EEG and multimodality evoked potentials (EP) in a patient with progressive myoclonus epilepsy (PME) with Lafora bodies in the sweat glands from the axillary skin biopsy...
  22. ncbi [A case of juvenile type dentatorubral-pallidoluysian atrophy (DRPLA) with psychomotor retardation since infancy]
    Y Wada
    Department of Pediatrics, Osaka University School of Medicine
    No To Hattatsu 30:543-8. 1998
    ..At the age of 6 years, he had progressive myoclonus epilepsy (PME) and underwent a series of neuroradiological, electrophysiological and pathological examinations, which failed to ..
  23. ncbi Methylating activity in ovarian membranes changes during the estrous cycle
    L B Oliveros
    Laboratory of Biology of the Reproduction, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Argentina
    Horm Metab Res 29:242-6. 1997
    ..and the other one, (Met II), catalyses the two successive methylations of phosphatidyl-N-monomethylethanolamine (PME) to phosphatidylcholine (PC). Met I shows a Km value of 5.71 microM and a Vm of 1...
  24. pmc Biliary drainage for obstructive jaundice enhances hepatic energy status in humans: a 31-phosphorus magnetic resonance spectroscopy study
    D V Mann
    Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Gut 50:118-22. 2002
    ..Biliary obstruction impairs liver function although the pathophysiological mechanism is incompletely understood...
  25. doi Amyloid fibril formation by human stefins: Structure, mechanism & putative functions
    Eva Zerovnik
    Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
    Biochimie 92:1597-607. 2010
    ..It also has been shown that endogenous stefin B (with E at site 31) but especially the EPM1 mutant R68X and Y31-stefin B variant, and to a lesser extent EPM1 mutant G4R, are prone to form aggregates in cells.
  26. ncbi Role of cathepsins and cystatins in patients with recurrent miscarriage
    Tamao Nakanishi
    Department of Obstetrics and Gynecology and 2nd Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho, Nagoya, 467 8601, Japan
    Mol Hum Reprod 11:351-5. 2005
    ..Immunohistochemistry was performed with antibodies against cathepsins, stefin A (cystatin A), stefin B (cystatin B) and cystatin C...
  27. ncbi Safety profile of celecoxib as used in general practice in England: results of a prescription-event monitoring study
    Deborah Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, SO31 1AA, UK
    Eur J Clin Pharmacol 60:489-501. 2004
    ..A post-marketing surveillance study using the technique of Prescription Event Monitoring was undertaken to monitor the safety of celecoxib, a cyclo-oxygenase (COX)-2 inhibitor, as prescribed in primary care in England...
  28. doi Scophthalmus maximus cystatin B enhances head kidney macrophage-mediated bacterial killing
    Ping ping Xiao
    Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, PR China
    Dev Comp Immunol 34:1237-41. 2010
    ..In this report, we described the identification and analysis of a cystatin B homologue, SmCytB, from turbot Scophthalmus maximus...
  29. doi The relationship between porcine circovirus 2 antigen score and antibody titre and histology of lymph nodes in 375 euthanased sick and healthy pigs from 113 British pig farms with and without postweaning multisystemic wasting syndrome
    M J Turner
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Prev Vet Med 88:213-9. 2009
    ..sick pigs with the clinical signs above and one healthy pig of a similar age were taken for postmortem examination (PME). In all other herds at least one healthy pig was taken for PME...
  30. ncbi [Metabolic kinetics in the brains in infants with IUGR, respiratory distress syndrome, seizures and asphyxia]
    H Yoshioka
    Department of Pediatrics, Kyoto Prefectural University of Medicine
    No To Hattatsu 24:159-63. 1992
    ..of cerebral phosphorus compounds: ATP, phosphocreatine (PCr), inorganic phosphate (Pi), phosphomonoesters (PME) and phosphodiesters (PDE)...
  31. pmc Biochemical metabolic changes assessed by 31P magnetic resonance spectroscopy after radiation-induced hepatic injury in rabbits
    Ri Sheng Yu
    Department of Internal Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
    World J Gastroenterol 15:2723-30. 2009
    ....
  32. doi Substituent effect on oxygen atom transfer reactivity from oxomolybdenum centers: synthesis, structure, electrochemistry, and mechanism
    Partha Basu
    Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Inorg Chem 48:6303-13. 2009
    ..and R = OMe, Me, SMe, NHCOMe, H, Cl, CF(3), NO(2), were reacted with trimethyl phosphine (PMe(3)) to convert into complexes of general formula Tp*MoO(S- p-RC(6)H(4))(OPMe(3)) (2) (where R = OMe, Me, SMe, H, Cl,..
  33. ncbi 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients
    H P Volz
    Department of Psychiatry, University of Jena, Germany
    Eur Arch Psychiatry Clin Neurosci 248:289-95. 1998
    ..Reduced frontal and temporal lobe phosphomonoester (PME) concentrations were measured in the euthymic state, whereas increased values were found in the depressed state...
  34. ncbi Analysis of different de-esterification mechanisms for pectin by enzymatic fingerprinting using endopectin lyase and endopolygalacturonase II from A. niger
    G Limberg
    Danisco Biotechnology, Copenhagen K, Denmark
    Carbohydr Res 327:293-307. 2000
    ..pectins with different distribution patterns of methyl ester groups was produced by treatment with either plant (p-PME) or fungal pectin methyl esterases (f-PME) and compared with those obtained by base catalysed de-esterification...
  35. pmc Molecular background of progressive myoclonus epilepsy
    Anna Elina Lehesjoki
    Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014 Helsinki, Finland
    EMBO J 22:3473-8. 2003
    ..Mutations in the gene encoding cystatin B (CSTB), a cysteine protease inhibitor, are responsible for the primary defect in Unverricht-Lundborg disease...
  36. doi Clinical picture of EPM1-Unverricht-Lundborg disease
    Reetta Kalviainen
    Kuopio Epilepsy Center, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
    Epilepsia 49:549-56. 2008
    ..The diagnosis of EPM1 can be confirmed by identifying disease-causing mutations in a cysteine protease inhibitor cystatin B (CSTB) gene...
  37. ncbi Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene
    G Andrei
    Laboratory of Antiviral Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Gen Virol 81:639-48. 2000
    ..HPMP) derivatives of cytosine (HPMPC, cidofovir) and adenine (HPMPA) and 2-phosphonylmethoxyethyl (PME) derivatives of adenine (PMEA, adefovir) and 2,6-diaminopurine (PMEDAP)...
  38. ncbi Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
    Megan K Houseweart
    Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305, USA
    J Neurobiol 56:315-27. 2003
    ..Unverricht-Lundborg disease (EPM1) is caused by loss-of-function mutations in the cysteine protease inhibitor, cystatin B. Because cystatin B inhibits a class of lysosomal cysteine proteases called cathepsins, we hypothesized that ..
  39. ncbi Towards the mechanism of trimeric purine nucleoside phosphorylases: stopped-flow studies of binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine
    B Wielgus-Kutrowska
    Department of Biophysics, Warsaw University, Poland
    Biophys Chem 125:260-8. 2007
    The binding of multisubstrate analogue inhibitor - 2-amino-9-[2-(phosphonomethoxy)ethyl]-6-sulfanylpurine (PME-6-thio-Gua) to purine nucleoside phosphorylase from Cellulomonas sp...
  40. doi Determination of cerium ion by polymeric membrane and coated graphite electrode based on novel pendant armed macrocycle
    Ashok K Singh
    Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India
    Anal Chim Acta 675:170-80. 2010
    ..The performance of the membrane based on L(2) was compared with polymeric membrane electrode (PME) as well as with coated graphite electrode (CGE)...
  41. ncbi A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3
    K Yamakawa
    Ahmanson Department of Pediatrics, Cedars Sinai Research Institute, UCLA, USA
    Cytogenet Cell Genet 74:140-5. 1996
    The Unverricht-Lundborg type of progressive myoclonus epilepsy (EPM1) has been mapped to human chromosome 21q22.3, and the candidate region has been narrowed to a region of less than 300 kb...
  42. ncbi A new clinical and molecular form of Unverricht-Lundborg disease localized by homozygosity mapping
    Samuel F Berkovic
    Epilepsy Research Centre and Department of Medicine Neurology, University of Melbourne, Austin Health, Heidelberg West, Victoria, Australia
    Brain 128:652-8. 2005
    ..ULD has previously been mapped to a locus on chromosome 21 (EPM1). Subsequently, mutations in the cystatin B gene have been found in most cases...
  43. ncbi Polymerase chain reaction-based analysis using deaminated DNA of dodecamer expansions in CSTB, associated with Unverricht-Lundborg myoclonus epilepsy
    H Horiuchi
    Department of Experimental and Forensic Pathology, Yamagata University Faculty of Medicine, Japan
    Genet Test 9:328-33. 2005
    ..The majority of affected individuals carry repeat expansions of a dodecamer in the promoter region of the cystatin B gene...
  44. ncbi Pelvic muscle exercise effect on pelvic muscle performance in women
    A R Boyington
    School of Nursing, University of North Carolina, Chapel Hill 27599-7460, USA
    Int Urogynecol J Pelvic Floor Dysfunct 11:212-8. 2000
    ..There was no significant difference in the baseline (P = 0.09) and post-PME (P = 0.63) strength, endurance and contractability of the two groups of women...
  45. ncbi The amino acid sequences, structure comparisons and inhibition kinetics of sheep cathepsin L and sheep stefin B
    A Ritonja
    Department of Biochemistry and Molecular Biology, J Stefan Institute, Jamova, Ljubljana, Slovenija
    Comp Biochem Physiol B Biochem Mol Biol 114:193-8. 1996
    ....
  46. ncbi Synthesis and reactivity of phosphine-stabilized phosphoranimine cations, [R3P x PR'2=NSiMe3]+
    Keith Huynh
    Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario, Canada M5S 3H6
    J Am Chem Soc 131:7905-16. 2009
    ..7) and the corresponding tertiary phosphines R(3)P or the diphosphines Me(2)P(CH(2))(n)PMe(2) (n = 1, 2)...
  47. ncbi Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis
    J Kos
    Jozef Stefan Institute, Department of Biochemistry and Molecular Biology, Ljubljana, Slovenia
    Clin Cancer Res 6:505-11. 2000
    ....
  48. doi Sulfur oxygenates of biomimetics of the diiron subsite of the [FeFe]-hydrogenase active site: properties and oxygen damage repair possibilities
    Tianbiao Liu
    Department of Chemistry, Texas A and M University, College Station, Texas 77843, USA
    J Am Chem Soc 131:8296-307. 2009
    ..site of [FeFe]-hydrogenase: (mu-pdt)[Fe(CO)(2)L][Fe(CO)(2)L'] (L = L' = CO (1); L = PPh(3), L' = CO (2); L = L' = PMe(3) (4)) and (mu-pdt)(mu-H)[Fe(CO)(2)PMe(3)](2) (5)...
  49. pmc Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803
    Carola A S Arndt
    Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Oncol 27:5182-8. 2009
    ....
  50. doi Boron toxicity is alleviated by hydrogen sulfide in cucumber (Cucumis sativus L.) seedlings
    Bao Lan Wang
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing 100093, People s Republic of China
    Planta 231:1301-9. 2010
    ..There was an increase in the activity of pectin methylesterase (PME) and up-regulated expression of genes encoding PME (CsPME) and expansin (CsExp) on exposure to high B concentration...
  51. ncbi In vivo and ex vivo study of metabolic and cellular effects of 5-fluorouracil chemotherapy in a mouse mammary carcinoma
    J C Street
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Magn Reson Imaging 15:587-96. 1997
    ..were observed in the phosphomonoester region of the in vivo NMR spectrum, phosphocholine (PC) and a peak (denoted PME') comprised of mainly phosphoethanolamine (PE)...
  52. pmc Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T
    Nivedita Agarwal
    The Brain Institute, University of Utah, 383 Colorow Drive, Salt Lake City, UT 84102, USA
    Bipolar Disord 12:825-33. 2010
    ..In humans, uridine is an important precursor of cytidine diphosphate (CDP)-choline, which plays a critical role in phospholipid synthesis and is currently being evaluated as a potential treatment for bipolar depression...
  53. doi Nano-level monitoring of Yb(III) by fabrication of coated graphite electrode based on newly synthesized hexaaza macrocyclic ligand
    Ashok K Singh
    Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India
    Anal Chim Acta 643:74-82. 2009
    ..The performance of the membrane based on L2 was compared with polymeric membrane electrode (PME) as well as with coated graphite electrode (CGE)...
  54. pmc Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy
    Gurjinder Kaur
    Nathan S Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Am J Pathol 177:2256-67. 2010
    ..Loss-of-function mutations in the cystatin B (CysB) gene, an intracellular cysteine protease inhibitor, lead to this human disease...
  55. ncbi Nutrient limitation in soils exhibiting differing nitrogen availabilities: what lies beyond nitrogen saturation?
    Stephen E Gress
    West Virginia University, Department of Biology, Morgantown, West Virginia 26506 6057, USA
    Ecology 88:119-30. 2007
    ..Viola rotundifolia, to compare indices of N availability to the activity of root-associated phosphomonoesterase (PME) activity at two spatial scales...
  56. ncbi Synthesis, structure, and electrochemical properties of sterically protected molybdenum trihydride redox pairs: a paramagnetic "stretched" dihydrogen complex?
    Miguel Baya
    Laboratoire de Chimie de Coordination, UPR CNRS 8241 liée par convention à l Université Paul Sabatier et à l Institut National Polytechnique de Toulouse, 205 route de Narbonne, 31077 Toulouse Cedex, France
    Chemistry 13:5347-59. 2007
    Complexes [MoCp(#)(PMe(3))(2)H(3)] (Cp(#)=1,2,4-C(5)H(2)tBu(3), 2 a; C(5)HiPr(4), 2 b) have been synthesized from the corresponding compounds [MoCp(#)Cl(4)] (1 a, 1 b) and fully characterized, including by X-ray crystallography and by a ..
  57. pmc Cell wall polysaccharides are specifically involved in the exclusion of aluminum from the rice root apex
    Jian Li Yang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
    Plant Physiol 146:602-11. 2008
    ..Root tip cell wall pectin methylesterase (PME) activity was constitutively higher in 'Zhefu802' than in 'Nipponbare', although Al treatment resulted in increased ..
  58. doi Development of electrochemical sensors for nano scale Tb(III) ion determination based on pendant macrocyclic ligands
    Ashok K Singh
    Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India
    Anal Chim Acta 633:109-18. 2009
    ..The performance of the membrane based on L(1) was compared with polymeric membrane electrode (PME) as well as with coated graphite electrode (CGE)...
  59. doi Development and evaluation of monoclonal antibodies as probes to assess the differences between two tomato pectin methylesterase isoenzymes
    Evelien Vandevenne
    Laboratory of Food Technology and Leuven Food Science and Nutrition Research Centre LFoRCe, Department of Microbial and Molecular Systems M2S, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, 3001 Leuven, Belgium
    J Immunol Methods 349:18-27. 2009
    The enzyme pectin methylesterase (PME) was purified from red ripe tomatoes (Lycopersicon esculentum) and through affinity chromatography two isoenzymes were fractionated (t1PME and t2PME)...
  60. ncbi On the mechanism of human stefin B folding: I. Comparison to homologous stefin A. Influence of pH and trifluoroethanol on the fast and slow folding phases
    E Zerovnik
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Proteins 32:296-303. 1998
    ..If folding was performed in the presence of 7% of TFE, rate acceleration and difference in the mechanism were observed...
  61. ncbi Tomato pectin methylesterase: modeling, fluorescence, and inhibitor interaction studies-comparison with the bacterial (Erwinia chrysanthemi) enzyme
    Rossana D'Avino
    Institute of Protein Biochemistry, CNR, Napoli, Italy
    Proteins 53:830-9. 2003
    The molecular model of Lycopersicon esculentum (tomato) pectin methylesterase (PME) was built by using the X-ray crystal structure of PME from the phytopathogenic bacterium Erwinia chrysanthemi as a template...
  62. pmc Overexpression of pectin methylesterase inhibitors in Arabidopsis restricts fungal infection by Botrytis cinerea
    Vincenzo Lionetti
    Dipartimento di Biologia Vegetale, Universita di Roma La Sapienza, 00185 Rome, Italy
    Plant Physiol 143:1871-80. 2007
    ..wall, is secreted in a highly methylesterified form and is demethylesterified in muro by pectin methylesterase (PME)...
  63. ncbi Elaborate spatial patterning of cell-wall PME and PMEI at the pollen tube tip involves PMEI endocytosis, and reflects the distribution of esterified and de-esterified pectins
    Nina Röckel
    Heidelberg Institute for Plant Sciences, INF 360, 69120 Heidelberg, Germany
    Plant J 53:133-43. 2008
    ..tubes, several pectin methylesterases (PMEs), enzymes that de-esterify pectins, are co-expressed with different PME inhibitors (PMEIs)...
  64. doi Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth, carcass, and production traits in Italian Large White pigs
    V Russo
    Dipartimento di Protezione e Valorizzazione Agroalimentare, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, 42100 Reggio Emilia, Italy
    J Anim Sci 86:3300-14. 2008
    ..cathepsin F, CTSF; cathepsin H, CTSH; cathepsin L, CTSL; and cathepsin Z, CTSZ) and for a cathepsin inhibitor (cystatin B) were investigated...
  65. ncbi Pectin methylesterase regulates methanol and ethanol accumulation in ripening tomato (Lycopersicon esculentum) fruit
    C Frenkel
    Department of Plant Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 273:4293-5. 1998
    We provide genetic evidence that the production of methanol in tomato fruit is regulated by pectin methylesterase (PME, EC 3.1.1.11), an enzyme that catalyzes demethoxylation of pectins...
  66. ncbi Interactions of calf spleen purine nucleoside phosphorylase with 8-azaguanine, and a bisubstrate analogue inhibitor: implications for the reaction mechanism
    Jacek Wierzchowski
    Department of Biophysics, University of Warmia and Mazury, 4 Oczapowskiego St, PL 10 719 Olsztyn, Poland
    Z Naturforsch C 59:713-25. 2004
    ..substrate, 8-azaguanine (8-azaG), and a bisubstrate analogue inhibitor, 9-(2-phosphonylmethoxyethyl)-8-azaguanine (PME-azaG), were investigated by means of steady-state fluorescence spectroscopy...
  67. ncbi Separation of pectin methylesterase isoenzymes from tomato fruits using short monolithic columns
    Irena Vovk
    Laboratory for Food Chemistry, National Institute of Chemistry, Hajdrihova 19, SI 1000 Ljubljana, Slovenia
    J Chromatogr A 1065:121-8. 2005
    One of the main forms of tomato pectin methylesterase (PME; EC 3.1.1.1.1) that is applicable to the food industry was isolated from fresh tomato fruit...
  68. ncbi Multiple Modes for Coordination of Phenazine to Molybdenum: Ring Fusion Promotes Access to eta(4)-Coordination, Oxidative Addition of Dihydrogen and Hydrogenation of Aromatic Nitrogen Compounds
    Aaron Sattler
    Department of Chemistry, Columbia University, New York, New York 10027
    J Am Chem Soc 131:7828-38. 2009
    Mo(PMe(3))(6) reacts with phenazine (PhzH) to give (eta(6)-C(6)-PhzH)Mo(PMe(3))(3), (mu-eta(6),eta(6)-PhzH)[Mo(PMe(3))(3)](2) and (eta(4)-C(4)-PhzH)(2)Mo(PMe(3))(2), each of which displays previously unknown coordination modes for ..
  69. ncbi Identification of the sodium-calcium exchanger as the major ricin-binding glycoprotein of bovine rod outer segments and its localization to the plasma membrane
    D M Reid
    Department of Biochemistry, University of British Columbia, Vancouver, Canada
    Biochemistry 29:1601-7. 1990
    ..existence of two major polypeptides of Mr 215K and 103K, the former of which was found to specifically react with PMe 1B3, a monoclonal antibody specific for the 230-kDa non-neuraminidase-treated Na+/Ca2+ exchanger...
  70. ncbi The NNP-1 gene (D21S2056E), which encodes a novel nuclear protein, maps in close proximity to the cystatin B gene within the EPM1 and APECED critical region on 21q22.3
    E Jansen
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, Belgium
    Genomics 42:336-41. 1997
    ..3, close to markers D21S1459 and D21S1953, that is 25 kb distal to the gene encoding cystatin B. Finally, an as-yet unknown gene that is highly related to NNP-1 was found proximal to the gene encoding ..
  71. ncbi Differences in the effects of TFE on the folding pathways of human stefins A and B
    E Zerovnik
    Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Ljubljana, Slovenia
    Proteins 36:205-16. 1999
    ..The results imply that the alpha-helical intermediate of stefin B is highly structured. Proteins 1999;36:205-216...
  72. ncbi The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin
    Jin Song
    Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA
    Biochem Biophys Res Commun 340:175-82. 2006
    We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines...
  73. ncbi Hydride transfer reactivity of tetrakis(trimethylphosphine)(hydrido)(nitrosyl)molybdenum(0)
    Yin Zhao
    Department of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Dalton Trans . 2006
    The tetrakis(trimethylphosphine) molybdenum nitrosyl hydrido complex trans-Mo(PMe(3))(4)(H)(NO) (2) and the related deuteride complex trans-Mo(PMe(3))(4)(D)(NO) (2a) were prepared from trans-Mo(PMe(3))(4)(Cl)(NO) (1)...
  74. ncbi Role of lipid charge in organization of water/lipid bilayer interface: insights via computer simulations
    Anton A Polyansky
    Department of Bioengineering, Biological Faculty, M V Lomonosov Moscow State University, Moscow 119992, Russia
    J Phys Chem B 109:15052-9. 2005
    ..were treated with two different algorithms: spherical cutoff function and particle-mesh Ewald summation (PME)...
  75. ncbi [Construction and immunogenicity of recombinant adenovirus tandem expressing M and GP5 of porcine reproductive and respiratory syndrome virus]
    Wen Ming Jiang
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Sheng Wu Gong Cheng Xue Bao 22:555-60. 2006
    ..The constructed plasmid was linearized with Pme I and co-transformed BJ5183 host bacteria with pAdEasy-1 to produce recombinant adenovirus DNA by homologous ..
  76. pmc Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesions
    Ashley G Rivenbark
    Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Exp Mol Pathol 83:188-97. 2007
    b>CST6 is a breast tumor suppressor gene that is expressed in normal breast epithelium, but is epigenetically silenced as a consequence of promoter hypermethylation in metastatic breast cancer cell lines...
  77. doi High-throughput screening of Erwinia chrysanthemi pectin methylesterase variants using carbohydrate microarrays
    Jens Øbro
    Department of Biology, University of Copenhagen, Copenhagen N, Denmark
    Proteomics 9:1861-8. 2009
    ..developed a novel microarray-based approach to investigate the activity of a series of variant enzymes based on the PME from the important pathogen Erwinia chrysanthemi. A library of 99 E...
  78. doi Differential expression of genes in resistant versus susceptible Gyr x Holstein cattle challenged with the tick Rhipicephalus (Boophilus) microplus
    C S Nascimento
    Departamento de Zootecnia, Universidade Federal de Vicosa, Campus Universitario, Vicosa, MG, Brasil
    Genet Mol Res 9:1974-9. 2010
    ..channel protein transient receptor potential vanilloid 6 (TRPV6), and the cysteine proteinase inhibitor gene (CST6)...
  79. doi Nature of M-Ga Bonds in cationic metal-gallylene complexes of iron, ruthenium, and osmium, [(η5-C5H5)(L)2M(GaX)]+: a theoretical study
    Krishna K Pandey
    School of Chemical Sciences, Devi Ahilya University Indore, Indore 452001, India
    Inorg Chem 50:1798-807. 2011
    ..half-sandwich gallylene complexes of iron, ruthenium, and osmium [(η(5)-C(5)H(5))(L)(2)M(GaX)](+) (M = Fe, L = CO, PMe(3); X = Cl, Br, I, NMe(2), Mes; M = Ru, Os: L = CO, PMe(3); X = I, NMe(2), Mes) at the BP86/TZ2P/ZORA level of ..
  80. pmc PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease
    Julie Turnbull
    Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
    PLoS Genet 7:e1002037. 2011
    ..most common teenage-onset neurodegenerative disease, the main teenage-onset form of progressive myoclonus epilepsy (PME), and one of the severest epilepsies...
  81. doi Brassinosteroids regulate pectin methylesterase activity and AtPME41 expression in Arabidopsis under chilling stress
    Tao Qu
    School of Life Sciences, Key Lab of Arid and Grassland Agroecology of MOE, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, China
    Cryobiology 63:111-7. 2011
    ..Chilling stress or 24-epibrassinolide (eBL) treatments induced significant increases in PME activity in wild type (Col-0) seedlings of Arabidopsis...
  82. doi [4 + 2] Cyclocondensation reactions of tungsten-dihydropyridine complexes and the generation of tri- and tetrasubstituted piperidines
    Daniel P Harrison
    Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States
    J Am Chem Soc 133:18378-87. 2011
    ..preparation of functionalized piperidines is described in which various dihydropyridine (DHP) complexes of {TpW(NO)(PMe(3))} that are derived from pyridine-borane undergo [4 + 2] cyclocondensation with enones, enals, nitrosobenzene, ..
  83. doi Efficient DNA strand displacement by a W-shaped nucleoside analogue (WNA-βT) containing an ortho-methyl-substituted phenyl ring
    Eriko Aoki
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Chembiochem 13:1152-60. 2012
    ..It was found that the homopurine TFO containing meta- and para-methyl-substituted WNA-βT (mMe-WNA-βT, pMe-WNA-βT) stabilized triplexes containing a TA interrupting site or a GC site, respectively...
  84. doi Cystatin B homolog from rock bream Oplegnathus fasciatus: genomic characterization, transcriptional profiling and protease-inhibitory activity of recombinant protein
    H K A Premachandra
    Department of Marine Life Sciences, School of Marine Biomedical Science, Jeju National University, Jeju Special Self Governing Province 690 756, Republic of Korea
    Comp Biochem Physiol B Biochem Mol Biol 163:138-46. 2012
    ..RbCyt B showed closest phylogenetic distance to Dicentrarchus labrax cystatin B, and shared up to 73% amino acid identity and 90% amino acid similarity with known cystatin B genes...
  85. doi Plant cell wall homeostasis is mediated by brassinosteroid feedback signaling
    Sebastian Wolf
    Institut Jean Pierre Bourgin, UMR1318 INRA AgroParisTech, Saclay Plant Science, 78026 Versailles, France
    Curr Biol 22:1732-7. 2012
    ..are complex block cell wall polymers, which can be modified in the wall by the enzyme pectin methylesterase (PME)...
  86. doi Functional expression of amyloidogenic human stefins A and B in Pichia pastoris using codon optimization
    Kosuke Nakamura
    Food, Nutrition and Health, University of British Columbia, Vancouver, Canada
    Biotechnol Appl Biochem 60:283-8. 2013
    ..3 ± 13.5 (n = 3) and 95.4 ± 4.1 (n = 3) mg/L, respectively. Using this expression strategy, we demonstrated that high levels of bioactive recombinant HSA and HSB can be produced by fermentation in P. pastoris...
  87. pmc Characterization and transcript profiling of the pectin methylesterase (PME) and pectin methylesterase inhibitor (PMEI) gene families in flax (Linum usitatissimum)
    David Pinzón-Latorre
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    BMC Genomics 14:742. 2013
    ..b>PME activity may result in either rigidification or loosening of the cell wall, depending on the mode of ..
  88. pmc Risk of neurobehavioral disinhibition in prenatal methamphetamine-exposed young children with positive hair toxicology results
    Sarah K Himes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland Department of Pediatrics, Brown Center for the Study of Children at Risk, Warren Alpert Medical School of Brown University, Women and Infants Hospital of Rhode Island, Providence, RI Division of Community Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota Department of Psychology, The University of Tulsa, Tulsa, Oklahoma Department of Pediatrics, LABioMed Institute at Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, California Department of Family Science, Center on Young Adult Health and Development, University of Maryland School of Public Health, College Park, Maryland Department of Emergency Medicine and Psychiatry, University of Rochester Medical Center, Rochester, New York and Department of Pediatrics, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
    Ther Drug Monit 36:535-43. 2014
    The objective was to evaluate the effects of prenatal methamphetamine exposure (PME) and postnatal drug exposures identified by child hair analysis on neurobehavioral disinhibition at 6.5 years of age.
  89. pmc Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation
    Tarja Joensuu
    Folkhalsan Institute of Genetics, Helsinki, Finland Department of Medical Genetics, Haartman Institute and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland Neuroscience Center, University of Helsinki, Helsinki, Finland
    PLoS ONE 9:e89321. 2014
    ..inherited neurodegenerative disease, manifesting with myoclonus, seizures and ataxia, caused by mutations in the cystatin B (CSTB) gene...
  90. doi Enzyme activity and biochemical changes of three date palm cultivars with different softening pattern during ripening
    Somayeh Rastegar
    Department of Horticultural Science, Shiraz University, Shiraz, Iran
    Food Chem 134:1279-86. 2012
    ..The activities of invertase and cell wall-modifying enzymes, namely pectin methylesterase (PME), β-galactosidase (β-Gal), endo-1,4-β-D-glucanase (EGase), and cellulase were monitored during growth and ..
  91. doi The effects of bruising and temperature on enzyme activity and textural qualities of tomato juice
    Matthew T Held
    Robert Mondavi Institute, 1 Shields Ave, Davis, CA 95616, USA
    J Sci Food Agric 95:1598-604. 2015
    ..The objective of this study was to determine how bruising and exposure to high temperatures affect pectin methylesterase (PME) activation and the textural quality of tomato juice.
  92. pmc HIGHLY METHYL ESTERIFIED SEEDS is a pectin methyl esterase involved in embryo development
    Gabriel Levesque-Tremblay
    Departments of Botany G L T, G W H andWood Science S D M, Faculty of Forestry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4 andDepartment of Biological Science, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6 K M
    Plant Physiol 167:725-37. 2015
    ..in a highly methyl-esterified form that later can be differentially demethyl esterified by pectin methyl esterase (PME) to strengthen or loosen plant cell walls that contain pectin, including seed coat mucilage, a specialized ..
  93. pmc Simultaneous recording of fluorescence and electrical signals by photometric patch electrode in deep brain regions in vivo
    Yasuharu Hirai
    Department of Neurobiology and Physiology, Faculty of Medicine, Kyoto University, Kyoto, Kyoto, Japan and Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Kyoto, Japan
    J Neurophysiol 113:3930-42. 2015
    ..Accordingly, we developed a photometric patch electrode (PME) to overcome the depth limitation of optical measurements and also enable the simultaneous recording of neural ..
  94. doi Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma
    Chen Chen Lee
    Department of Microbiology and Immunology, School of Medicine, China Medicine University, Taichung, Taiwan
    Am J Chin Med 44:133-47. 2016
    ..Our study investigated the therapeutic potential of an extract of the root of Polygonum multiflorum (PME) in allergic asthma by using a mouse model. Feeding of 0...
  95. doi Extratemporal abnormalities in phosphorus magnetic resonance spectroscopy of patients with mesial temporal sclerosis
    Eun Joo Park
    Departamento de Radiologia, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Arq Neuropsiquiatr 74:93-8. 2016
    ..We evaluated extratemporal metabolic changes with phosphorus magnetic resonance spectroscopy (31P-MRS) in patients with unilateral mesial temporal sclerosis (MTS)...
  96. pmc Pattern of phenolic content, antioxidant activity and senescence-related enzymes in granulated vs non-granulated juice-sacs of 'Kinnow' mandarin (Citrus nobilis x C. deliciosa)
    R R Sharma
    Division of Food Science and Postharvest Technology, Indian Agricultural Research Institute, New Delhi, 110 012 India
    J Food Sci Technol 53:1525-30. 2016
    ..3 ± 0.31 μmoles min(-1) g(-1) FW) and pectin methylesterase (PME) (0.52 ± 0.12 μmol of NaOH g(-1) FW min(-1)) and had strong relationships with the occurrence of granulation...
  97. doi Progressive Myoclonus Epilepsy in Congenital Generalized Lipodystrophy type 2: Report of 3 cases and literature review
    Roberta Opri
    University Hospital of Verona, Department of Surgical Sciences, Gynecology and Pediatrics, Section of Child Neuropsychiatry, Piazzale L A Scuro 10, 37134 Verona, Italy Electronic address
    Seizure 42:1-6. 2016
    ..Herein we describe clinical and EEG features of three patients presenting with Progressive Myoclonus Epilepsy (PME) and Congenital Generalized Lipodystrophy type 2 (CGL2) related to novel Seipin mutations.
  98. doi Rice pectin methylesterase inhibitor28 (OsPMEI28) encodes a functional PMEI and its overexpression results in a dwarf phenotype through increased pectin methylesterification levels
    Hong Phuong Nguyen
    Graduate School of Biotechnology, Kyung Hee University, Yongin 446 701, Republic of Korea
    J Plant Physiol 208:17-25. 2017
    ..Optimal pectin methylesterification status in each cell type is determined by the balance between PME activity and post-translational PME inhibition by PME inhibitors (PMEIs)...
  99. ncbi Complainer Profile Identification (CPI): properties of a new questionnaire on subjective cognitive complaints
    Alexander F Lubitz
    a Department of Educational Science and Psychology, Freie Universitat Berlin, Berlin, Germany
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn . 2016
    ..The overall level of SCC is largely influenced by depressiveness, whereas executive complainers show the highest level of depressive affect, being overall younger and less socially integrated...
  100. ncbi Molecular dynamics simulations of human prion protein: importance of correct treatment of electrostatic interactions
    J Zuegg
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Biochemistry 38:13862-76. 1999
    ..could be achieved only by including all the long-range electrostatic interactions using the particle mesh Ewald (PME) method...
  101. ncbi Prophylactic mastectomy in familial breast carcinoma. What do the pathologic findings learn us?
    Karin Leunen
    Department of Obstetrics and Gynaecology, Division of Gynaecologic Oncology, Multidisciplinary Breast Centre, University Hospitals Leuven, Leuven, Belgium
    Breast Cancer Res Treat 107:79-86. 2008
    To evaluate the indications, techniques and pathologic findings of prophylactic mastectomy (pME).

Research Grants57

  1. Blood-brain barrier gene delivery in knock-out mice.
    EAIN CORNFORD; Fiscal Year: 2005
    ..promote a gene therapeutic through the BBB of knock-out mice with Lafora's Progressive Myoclonic Epilepsy (PME), after intravenous administration...
  2. Molecular Pathological Mechanism & Potential Therapeutics of Lafora Disease
    YAN NONE LIU; Fiscal Year: 2010
    ..disease (LD) is an autosomal recessive and incurable disease with characters of progressive myoclonus epilepsy (PME), severe neurological deterioration, and the accumulation of starch-like glycogen inclusion bodies (LB) mainly in ..
  3. CYSTATINS IN MALIGNANT PROGRESSION OF MCF10
    Bonnie Sloane; Fiscal Year: 1999
    ..Information gained from these studies will be useful for the design of exogenous cysteine protease inhibitors for therapeutic use. ..
  4. Cerebrospinal fluid proteome mediated signaling in the developing CNS
    Maria Lehtinen; Fiscal Year: 2011
    ..is a key mechanism triggering neurodegeneration in the progressive myoclonus epilepsy, Unverricht-Lundborg disease (EPM1)...
  5. Maria Lehtinen; Fiscal Year: 2014
    ..is a key mechanism triggering neurodegeneration in the progresive myoclonus epilepsy, Unverricht-Lundborg disease (EPM1)...
  6. MR Spectroscopy of the Liver in Correlation with Histology in NASH Patients
    Abdullah Al Osaimi; Fiscal Year: 2009
    ..Our goal is to demonstrate increased PME/PDE ratios with increasing fibrosis...
  7. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    Jeffrey Evelhoch; Fiscal Year: 1999
    ..These include elevations of phosphomonoesters (PME), phosphodiesters (PDE), and cellular pH, and dimished phosphocreatine (PCr)...
  8. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..MRS, in particular choline containing compounds (Cho), myo-Inositol containing compounds (Ino), phosphomonoesters (PME), phosphodiesters (PDE) and the nucleotide triphosphates (NTPs)...
  9. IN VIVO MR STUDIES OF METABOLISM IN ALZHEIMERS DISEASE
    JAY PETTEGREW; Fiscal Year: 2000
    ..of mildly demented probable AD subjects demonstrate increased membrane synthesis [increased phosphomonoesters (PME)] and increased energetic stress [decreased phosphocreatine (PCr)]...
  10. Cellular Targets of Polyomavirus Tumor Antigens
    David C Pallas; Fiscal Year: 2012
    ..of the PP2A catalytic subunit by Leucine Carboxy Methyltransferase (LCMT-1) and Protein Methylesterase-1 (PME-1) is the most specific cellular mechanism for regulating PP2A, and thus may have promise as a mechanism-based ..
  11. David P Giedroc; Fiscal Year: 2014
    ..as well as two multidomain proteins that harbor canonical thiosulfate sulfurtransferase or rhodanese domains (CstA, CstB) whose biological functions are unknown...
  12. CHARACTERIZATION OF TUMOR CYSTEINE INHIBITORS
    Bonnie Sloane; Fiscal Year: 1992
    ..Our eventual goal is to interrupt this cascade by designing more effective inhibitors or by altering the expression and subcellular localization of endogenous CPI...
  13. Linda E Rivera; Fiscal Year: 2014
    ..b>Cystatin B expression is positively correlated with HIV replication and decreased levels STAT-1 phosphorylation (STAT-1PY) ..
  14. Donald A Wilson; Fiscal Year: 2015
    ..of A2 degradation improves olfactory processing and perception by using mice which lack the protease inhibitor cystatin B (CBKO)...
  15. Urinary Incontinence in Older Men Post Prostatectomy
    Joanne Robinson; Fiscal Year: 2006
    ..a pilot randomized controlled trial will also be conducted to examine the effect of pelvic muscle exercise (PME) training on pelvic muscle strength, a modifiable physiologic factor, in men at risk of persistent UI following ..
  16. Clinical Suspicion of TB: A Technology Assessment Tool
    Antonino Catanzaro; Fiscal Year: 2007
    ..The Clinical Suspicion of TB (CSTB) instrument pro- vides a summary estimate of the pre-treatment likelihood of TB based on recognized epidemiologic, ..
  17. MAPPING OF THE GENES FOR TWO RECESSIVE DISORDERS
    Albert de la Chapelle; Fiscal Year: 1992
    ..highly incapacitating hereditary disorders, namely, Diastrophic Dysplasia (DD) and progressive Myoclonus Epilepsy (PME). Nothing is presently known about the pathogenesis of these disorders...
  18. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    Truman Brown; Fiscal Year: 2002
    ..These include elevations in PME, PDE, and of cellular pH, and dimininution of PCr...
  19. IN VIVO 31P-1H MRSI AND MRI BRAIN STUDIES OF NICOTINE
    JAY PETTEGREW; Fiscal Year: 2004
    ..phosphocreatine (PCr) and adenosine 5'-triphosphate] and membrane phospholipid metabolism [phosphomonoesters (PME) and phosphodiesters (PDE)] by 31P magnetic resonance spectroscopic imaging (MRSI) and on measures of N-..
  20. HOUSEHOLD RESPONSES TO ECONOMIC SHOCKS IN BRAZIL
    David Lam; Fiscal Year: 1999
    ..The project will use two exceptional data sets--the PNAD annual household surveys from 1976 to 1993, and the PME monthly employment survey from 1982 to 1995...
  21. MR Spectroscropy and Imaging in Head and Neck Tumors
    Harish Poptani; Fiscal Year: 2007
    ..This hypothesis will be tested with the following specific aims: Aim 1: To evaluate the utility of the PME/13 NTP ratio in predicting and detecting treatment response by 31p MRS, Aim 2: To determine if total choline (Cho) ..
  22. NMR STUDIES OF BRAIN AGING IN ALZHEIMER'S DISEASE
    William Klunk; Fiscal Year: 1990
    Recent 31P NMR studies from this laboratory have demonstrated increased levels of phosphomonoesters (PME) in Alzheimer disease (AD) brain as compared to normal and neurological controls and increased levels of phosphodiesters (PDE) in ..
  23. IN VIVO NMR STUDIES IN SCHIZOPHRENIA
    JAY PETTEGREW; Fiscal Year: 2000
    ..Our studies to date demonstrate decreased membrane synthesis [phosphomonoesters (PME)] and decreased energy consumption [phosphocreatine (PCr) and ATP] in the drug-naive, first-episode schizophrenics ..
  24. Structural biololgy of tumor suppressor PP2A and its regulatory proteins
    Yigong Shi; Fiscal Year: 2010
    ..The methylation of the C subunit, controlled by the PP2A methyl transferase (PMT) and the PP2A methyl esterase (PME), is essential to the function of PP2A...
  25. PREDICTING HUMAN TUMOR RESPONSE BY 31P MRS
    Martin Leach; Fiscal Year: 1999
    ..These include raised levels of phosphomonoesters (PME), phosphodiesters (PDE) and cellular pH, and reduced phosphocreatine (PCr)...
  26. GLOBAL AND REGIONAL CARDIAC METABOLISM: NMR STUDIES
    Craig Malloy; Fiscal Year: 1991
    ..Specifically, what is the, composition and significance of the phosphomonoester (PME) signal detected by 31 P NMR in preliminary studies of global ischemia...
  27. Specificity and function of PP2A carboxymethylation
    Jocelyn Lee; Fiscal Year: 2009
    ..PP2A is methylated on its catalytic subunit C-terminal leucine alpha-carboxy group by LCMT-1 and is demethylated by PME-1...
  28. DETERMINANTS OF CLINICAL VARIATION IN PRIMARY DEMENTIA
    GEORGE ZUBENKO; Fiscal Year: 2000
    ..genotyping into the prospective longitudinal study of the AD high-risk cohort and ongoing genetic studies of the PME locus...
  29. IN VIVO METABOLISM IN ALZHEIMER'S DISEASE
    JAY PETTEGREW; Fiscal Year: 1992
    ..AD brains contain significantly elevated levels of PME, which are precursors to membrane phospholipids, without significant elevations of PDE, which are breakdown ..
  30. Development of a portable PME DNA sequencer
    Michael Metzker; Fiscal Year: 2005
    ..To accomplish this, we describe experiments utilizing our PuIse-Multiline Excitation (PME) technology coupled with microfluidic separation chips...
  31. NMR STUDIES OF EXTREMITY SARCOMAS
    Jason Koutcher; Fiscal Year: 1999
    ..resolution, 1H spin decoupling will be used; previous murine and clinical studies have indicated that resolving the PME and PDE resonances into individual peaks, may yield further information, than the data that can be otherwise ..
  32. Development of Fluorescent Detector for DNA Sequencing
    Michael Metzker; Fiscal Year: 2004
    ..The proposed technology is called Pulse-Multiline Excitation or PME. The PME technology has two potential advantages, which could significantly increase fluorescence sensitivity: (1) ..
  33. Proteomic determination of arsenical action
    Partha Basu; Fiscal Year: 2005
    ..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
  34. PRENATAL MARIJUANA EXPOSURE: LONG-TERM OUTCOMES
    Nancy Day; Fiscal Year: 2009
    ..We will explore the effects of prenatal marijuana exposure (PME) on the offspring in young adulthood...
  35. ALCOHOL USE DURING PREGNANCY--A LONGITUDINAL STUDY
    Nancy Day; Fiscal Year: 2002
    ....
  36. Effects of Prenatal Alcohol Exposure at 22 Years
    Nancy L Day; Fiscal Year: 2010
    ..Little is known about the effects of lower levels of alcohol exposure during gestation. This is a proposal to identify the effects of low and moderate, as well as heavy levels of prenatal alcohol exposure. ..
  37. TOBACCO: PRENATAL EFFECTS AND ADOLESCENT USE
    Nancy Day; Fiscal Year: 2002
    ..We have assessed these mothers and their children at prenatal months 4 and 7, delivery, 8 and 18 months, 3, 6, and 10 years. We have an exceptional follow-up rate of 91% at 10 years. ..
  38. PRENATAL ALCOHOL EXPOSURE: LONG-TERM OUTCOMES
    Nancy Day; Fiscal Year: 2004
    ..This proposal will integrate these areas of research. ..
  39. Lafora's Progressive Myoclonus Epilepsy
    Antonio Delgado Escueta; Fiscal Year: 2003
    Lafora's PME is an autosomal recessive fatal disorder characterized by childhood learning disorder or adolescent stimuli sensitive myoclonic seizures, ataxia and progressive neurologic deterioration...
  40. DEVELOPMENT OF A LIVE ATTENUATED HSV-2 VACCINE
    Mark Prichard; Fiscal Year: 2002
    ..In addition further in vitro characterization will enable high quality clinical trial material to be produced for IND enabling primate studies and early Phase I human trials. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  41. Simulations on the early events of TTR amyloidogenesis
    Shuanghong Huo; Fiscal Year: 2005
    ..The proposed calculations will provide insight into the small-molecule strategy for intervening in the pathology of TTR related amyioid diseases. ..
  42. Gene Methylation and Therapeutic Response in Lung Cancer
    Steven Belinsky; Fiscal Year: 2005
    ..The validation of these genes as biomarkers of lung cancer risk and their detection in sputum and/or serum could ultimately support chemoprevention trials for preventing lung cancer. ..
  43. MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM
    Steven Belinsky; Fiscal Year: 2001
    ..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
  44. Macrophage Protein Fingerprints in HIV-1 Dementia
    Pawel Ciborowski; Fiscal Year: 2006
    ..The long-term goal of this aim is to uncover biomarkers specific for HAD and to see if they are based on products of immune competent virus-infected MDM as demonstrated in aim 1. ..
  45. The Role of Neuronal Integration in Working Memory
    Eric R Kandel; Fiscal Year: 2010
    ..How does HCN1 knockout affect the physiological properties of circuits involved in short-term memory both in the prefrontal cortex? 3) Does HCN1 influence the 'on-line'neural representation of information during working memory? ..
  46. InhibinB as a Marker for Premenstrual Dysphoric Symptoms
    SHIRLEY HARTLAGE; Fiscal Year: 2007
    ..Results are expected to provide clues to the cause of PMDD, facilitate the now burdensome diagnostic process, and lead to new treatments. [unreadable] [unreadable] [unreadable]..
  47. Modulation of Cystatins and Cathepsins in HIV-1 Neuropathogenesis
    Loyda M Melendez; Fiscal Year: 2010
    ..following specific aims: 1) To determine, by analysis of gene and protein expression, how the interplay between cystatin B and cathepsin B regulates HIV-1 infection in macrophages and affects neurotoxic phenotype;2) To define the roles ..
  48. Sequence Determinants of Meiotic Recombination Hotspots
    Walter Steiner; Fiscal Year: 2007
    ..pombe are also active in the distantly related budding yeast Saccharomyces cerevisiae. Sequences that are active in both organisms may be widely conserved among eukaryotes, including man. [unreadable] [unreadable] [unreadable]..
  49. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
  50. MULTIDICIPLINARY FUNCTIONAL IMAGING OF CANCER
    Zaver Bhujwalla; Fiscal Year: 2002
    ..abstract_text> ..
  51. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..abstract_text> ..
  52. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2006
    ....
  53. Frequency of aerobic/resistance training in older women
    Gary Hunter; Fiscal Year: 2009
    ..Such information is critical to our understanding of ways to improve well being, quality of life, and independence of an aging population. ..
  54. Brain Phospholipid Composition in Schizophrenia
    Richard Komoroski; Fiscal Year: 2004
    ..It will also potentially provide support and clarification for several aspects of the membrane hypothesis of schizophrenia. ..
  55. MD Study of Anthrax Edema Factor:Calmodulin Complexes
    Shuanghong Huo; Fiscal Year: 2003
    ..abstract_text> ..
  56. Image-Guided Pro-Drug/Enzyme Therapy
    Zaver Bhujwalla; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Role of PP2A in tauopathies
    Estelle Sontag; Fiscal Year: 2007
    ..subunit can be methylated by a specific methyltransferase (PPMT), and demethylated by a dedicated methylesterase (PME-1), whose properties and regulation in neurons have not yet been explored...