CSF1R

Summary

Gene Symbol: CSF1R
Description: colony stimulating factor 1 receptor
Alias: C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, macrophage colony-stimulating factor 1 receptor, CD115 antigen, CSF-1 receptor, FMS proto-oncogene, McDonough feline sarcoma viral (v-fms) oncogene homolog, macrophage colony stimulating factor I receptor, proto-oncogene c-Fms
Species: human

Top Publications

  1. pmc Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors
    B M Kacinski
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510
    Yale J Biol Med 62:379-92. 1989
  2. ncbi Carbon tetrachloride-induced hepatotoxicity enhances the development of pulmonary foam cells in rats fed a cholesterol-cholic acid diet
    K Shibuya
    Nippon Institute for Biological Science, Tokyo, Japan
    Toxicol Pathol 25:487-94. 1997
  3. ncbi Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells
    Kejian Zhu
    Department of Dermatology, University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 297:1211-7. 2002
  4. ncbi Biology and action of colony--stimulating factor-1
    E R Stanley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:4-10. 1997
  5. pmc Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression
    Hisamitsu Ide
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14404-9. 2002
  6. pmc Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
    Carolyn N Wrobel
    Dept of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 165:263-73. 2004
  7. ncbi The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain
    Mark Walter
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Mol Biol 367:839-47. 2007
  8. doi CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas
    Maria J Soares
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Mod Pathol 22:744-52. 2009
  9. doi Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase
    Olivier Zwaenepoel
    Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece
    FASEB J 26:691-706. 2012
  10. pmc The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines
    Andrea Morandi
    Dipartimento di Patologia e Oncologia Sperimentali, Universita degli Studi di Firenze, and Istituto Toscano Tumori, Firenze, Italy
    PLoS ONE 6:e27450. 2011

Detail Information

Publications356 found, 100 shown here

  1. pmc Oncogene expression in vivo by ovarian adenocarcinomas and mixed-mullerian tumors
    B M Kacinski
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510
    Yale J Biol Med 62:379-92. 1989
    ..In the benign, borderline, and invasive adenocarcinomas, multiple oncogenes, including neu, fes, fms, Ha-ras, trk, c-myc, fos, and PDGF-A chains, were expressed at significant levels relative to a housekeeping gene (..
  2. ncbi Carbon tetrachloride-induced hepatotoxicity enhances the development of pulmonary foam cells in rats fed a cholesterol-cholic acid diet
    K Shibuya
    Nippon Institute for Biological Science, Tokyo, Japan
    Toxicol Pathol 25:487-94. 1997
    ..The ratios of foamy, lipid-ingested monocytes (FMs) to blood monocytes (BMs) and the histologic scores of PFC development were significantly greater in the HB and HT ..
  3. ncbi Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells
    Kejian Zhu
    Department of Dermatology, University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 297:1211-7. 2002
    ....
  4. ncbi Biology and action of colony--stimulating factor-1
    E R Stanley
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Mol Reprod Dev 46:4-10. 1997
    ..The CSF-1R is a tyrosine kinase encoded by the c-fms proto-oncogene product...
  5. pmc Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression
    Hisamitsu Ide
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14404-9. 2002
    ..These observations correlate CSF-1R expression with changes in the growth and development of the normal and neoplastic prostate...
  6. pmc Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture
    Carolyn N Wrobel
    Dept of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    J Cell Biol 165:263-73. 2004
    ..These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers...
  7. ncbi The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain
    Mark Walter
    Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
    J Mol Biol 367:839-47. 2007
    c-Fms, a member of the Platelet-derived Growth Factor (PDGF) receptor family of receptor tyrosine kinases (RTKs), is the receptor for macrophage colony stimulating factor (CSF-1) that regulates proliferation, differentiation and survival ..
  8. doi CSF1R copy number changes, point mutations, and RNA and protein overexpression in renal cell carcinomas
    Maria J Soares
    Department of Genetics, Portuguese Oncology Institute, Porto, Portugal
    Mod Pathol 22:744-52. 2009
    ..tumors and paired normal kidney samples to evaluate at the genomic and expression levels the tyrosine kinase genes CSF1R and PDGFRB as potential targets in this region...
  9. doi Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase
    Olivier Zwaenepoel
    Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece
    FASEB J 26:691-706. 2012
    ..These findings may have important implications in cancer development...
  10. pmc The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines
    Andrea Morandi
    Dipartimento di Patologia e Oncologia Sperimentali, Universita degli Studi di Firenze, and Istituto Toscano Tumori, Firenze, Italy
    PLoS ONE 6:e27450. 2011
    ..The presence of a proliferative CSF-1/CSF-1R autocrine loop involving ERK1/2 was also found. The wide expression of the CSF-1/CSF-1R pair across breast cancer cell subtypes supports CSF-1/CSF-1R targeting in breast cancer therapy...
  11. doi Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    David A Hume
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom
    Blood 119:1810-20. 2012
    ..As a treatment, CSF-1 has therapeutic potential in tissue repair. Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but may have utility in cancer...
  12. pmc Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic Florida, Jacksonville, Florida, USA
    Nat Genet 44:200-5. 2011
    ..different mutations affecting the tyrosine kinase domain of the colony stimulating factor 1 receptor (encoded by CSF1R) in 14 families with HDLS. In one kindred, we confirmed the de novo occurrence of the mutation...
  13. pmc Macrophage proliferation is regulated through CSF-1 receptor tyrosines 544, 559, and 807
    Wenfeng Yu
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 287:13694-704. 2012
    ..Tyr-559 phosphorylation releases this restraint and may also contribute to the CSF-1-regulated proliferative response by activating Src family kinase...
  14. doi CSF1R mutations identified in three families with autosomal dominantly inherited leukoencephalopathy
    Jun Mitsui
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:951-7. 2012
    ..adult-onset sporadic leukodystrophy and one patient with pathologically proven HDLS were additionally screened for CSF1R mutations. Exome sequencing identified heterozygous CSF1R mutations (p.I794T and p.R777W) in two families...
  15. doi Adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia: report of five cases and a new mutation
    Kirk Kleinfeld
    Department of Neurology, Vanderbilt Multiple Sclerosis Center, Vanderbilt University Medical Center, 719 Thompson Lane 24100, Nashville, TN 37204, USA
    J Neurol 260:558-71. 2013
    ..by genetic analysis alone that showed a disease-causing mutation in the colony-stimulating factor 1 receptor (CSF1R) gene...
  16. pmc CSF1R mutations link POLD and HDLS as a single disease entity
    Alexandra M Nicholson
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Neurology 80:1033-40. 2013
    ..Recently, we reported that mutations in the colony-stimulating factor 1 receptor (CSF1R) gene cause HDLS. In this study, we determined whether CSF1R mutations are also a cause of POLD.
  17. pmc FMS mutations in myelodysplastic, leukemic, and normal subjects
    S A Ridge
    Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Proc Natl Acad Sci U S A 87:1377-80. 1990
    The FMS gene encodes the functional cell surface receptor for colony-stimulating factor 1, the macrophage- and monocyte-specific growth factor...
  18. ncbi The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1
    C J Sherr
    Cell 41:665-76. 1985
    The feline c-fms proto-oncogene product is a 170 kd glycoprotein with associated tyrosine kinase activity. This glycoprotein was expressed on mature cat macrophages from peritoneal inflammatory exudates and spleen...
  19. pmc Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts
    P van der Geer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, CA 92186 5800
    EMBO J 12:5161-72. 1993
    ..Tyr697 was identified as a binding site for GRB2. We suggest that PI 3-kinase, GRB2 and some of the GRB2-associated proteins could play an important role in signal transduction by the CSF-1 receptor...
  20. ncbi Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody
    M B Flick
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Oncogene 14:2553-61. 1997
    The macrophage colony stimulating factor receptor (CSF-1R), the product of the c-fms proto-oncogene, plays an important role in regulating the normal proliferation and differentiation of macrophages and trophoblasts...
  21. ncbi C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus
    Kevin Wilhelmsen
    Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0601, USA
    Oncogene 21:1079-89. 2002
    ..Our observations are consistent with a model in which receptor autophosphorylation at Tyr 973 creates a binding site for c-Cbl. Association of c-Cbl with the receptor leads to ubiquitination, followed by receptor degradation...
  22. ncbi A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation
    Cynthia M Rohde
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 279:43448-61. 2004
    ..These findings may have implications for the oncogenic conversion of c-Kit and Flt3 with JMD mutations...
  23. ncbi FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance
    J R Taylor
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Oncogene 25:147-51. 2006
    ..Here, we report that imatinib is also an effective inhibitor of the closely related FMS receptor for macrophage colony stimulating factor and that mutation of Asp 802 of FMS to Val confers imatinib ..
  24. doi Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease
    Luciano S Hammes
    Department of Obstetrics and Gynecology, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Gynecol Oncol 110:445-51. 2008
    ..of vascular endothelial growth factor (VEGF), proto-oncogene macrophage colony-stimulating factor receptor (c-fms) and cyclooxygenase-2 (COX-2) in cervical carcinogenesis and to analyze the correlation of VEGF with c-fms and COX-..
  25. pmc c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis
    Ricardo T Paniagua
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, CCSR 4135, 269 Campus Drive, Stanford, CA 94305, USA
    Arthritis Res Ther 12:R32. 2010
    ..drug that potently inhibits the tyrosine kinases Abl, c-Kit, platelet-derived growth factor receptor (PDGFR), and c-Fms--ameliorates murine autoimmune arthritis...
  26. doi Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood
    Hiroyuki Eda
    Discovery Biology, Global Research and Development, St Louis Laboratories, Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Cytokine 52:215-20. 2010
    ..if an M-CSF- or IL-34-induced cytokine or chemokine production from HWB is inhibited by soluble M-CSF receptor or c-FMS kinase inhibitors...
  27. ncbi Hormonal regulation of the c-fms proto-oncogene in breast cancer cells is mediated by a composite glucocorticoid response element
    Maryann B Flick
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06510 8040, USA
    J Cell Biochem 85:10-23. 2002
    We have previously reported that glucocorticoids markedly increase and anti-glucocorticoids (such as RU-486) block c-fms RNA and protein expression in some breast cancer cell lines, but not in others, and that this increase is the ..
  28. ncbi C-fms expression correlates with monocytic differentiation in PML-RAR alpha+ acute promyelocytic leukemia
    R Riccioni
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Rome, Italy
    Leukemia 17:98-113. 2003
    We have investigated the expression of the M-CSF receptor (c-fms) in 16 freshly isolated acute promyelocytic leukemias (APL) expressing the PML/RAR alpha fusion protein...
  29. ncbi Oncogenes and tumor suppressor genes
    G Klein
    Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden
    Acta Oncol 27:427-37. 1988
    ..of continuous, faulty signalling by the truncation of their external, ligand binding portion (examples: erb-B, fms)...
  30. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..e., podoplanin, the hyaluronate receptor LYVE-1, and the vascular endothelial cell growth factor (VEGF)-C receptor, fms-like tyrosine kinase 4 (Flt-4)/VEGFR-3, were strongly expressed by expanded LECs, but not BECs...
  31. ncbi [Abnormalities of the p53, N-ras, DCC and FLT-3 genes in myelodysplastic syndromes]
    K Nakamura
    Department of 3rd Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:143-8. 2001
    ..In the present study, mutations of N-ras, p53 and FMS-like tyrosine kinase 3 (FLT-3) genes and loss of expression of the deleted in colorectal carcinoma (DCC) gene were ..
  32. ncbi Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response
    O M Mitrasinovic
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 276:30142-9. 2001
    ..We showed previously that macrophage colony-stimulating factor receptor (M-CSFR), encoded by the c-fms protooncogene, is overexpressed on microglia surrounding amyloid beta (Abeta) deposits in ..
  33. pmc Expression of mRNA encoding the macrophage colony-stimulating factor receptor (c-fms) is controlled by a constitutive promoter and tissue-specific transcription elongation
    X Yue
    Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 13:3191-201. 1993
    The gene encoding the receptor for macrophage colony-stimulating factor 1 (CSF-1), the c-fms protooncogene, is selectively expressed in immature and mature mononuclear phagocytes and trophoblasts. Exon 1 is expressed only in trophoblasts...
  34. ncbi Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells
    R A Ashmun
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38101
    Blood 73:827-37. 1989
    The first monoclonal antibodies (MoAbs) to epitopes in the extracellular domain of the human c-fms proto-oncogene product (receptor for the macrophage colony stimulating factor, CSF-1) were used with flow cytometric techniques to study ..
  35. ncbi Growth factor receptor expression during in vitro differentiation of partially purified populations containing murine stem cells
    E Ashihara
    Laboratory of Hematopoietic Growth Factors, Lindsley F Kimball Research Institute, New York Blood Center, New York 10021, USA
    J Cell Physiol 171:343-56. 1997
    ..colony-stimulating factor (GM-CSF) receptor, the erythropoietin receptor, the G-CSF receptor, and c-Fms, the receptor for macrophage colony-stimulating factor (M-CSF)...
  36. ncbi Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution
    W V Williams
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104
    Arthritis Rheum 37:1468-78. 1994
    ..characteristics of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain (sGM-CSFR alpha), and analyze transcript expression in immune cells and the cellular constituents of rheumatoid arthritis ..
  37. ncbi Oligomerization of the soluble granulocyte-macrophage colony-stimulating factor receptor: identification of the functional ligand-binding species
    C B Brown
    Department of Medicine, The University of Calgary, Alberta, Canada
    Cytokine 9:219-25. 1997
    The ligand-specific alpha subunit of the dimeric human GM-CSF receptor exists in both transmembrane anchored (tmGM-CSFR alpha) and soluble (sGM-CSFR alpha) isoforms...
  38. pmc Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
    Hiromi Tagoh
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    EMBO J 23:4275-85. 2004
    The murine c-fms (Csf1r) gene encodes the macrophage colony-stimulating factor receptor, which is essential for macrophage development...
  39. ncbi Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib
    Andrea L Dewar
    Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia
    Blood 105:3127-32. 2005
    ..we demonstrate for the first time that imatinib targets the macrophage colony-stimulating factor (M-CSF) receptor c-fms. Phosphorylation of c-fms was inhibited by therapeutic concentrations of imatinib, and this was not due to down-..
  40. ncbi c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis
    George Alexander Follows
    Molecular Medicine Unit, St James s University Hospital, Leeds, UK
    Oncogene 24:3643-51. 2005
    The macrophage colony-stimulating factor receptor is encoded by the c-FMS gene, and it has been suggested that altered regulation of c-FMS expression may contribute to leukaemic transformation...
  41. ncbi Expression of M-CSF and its receptor (C-FMS) during factor-independent cell line evolution from hematopoietic progenitor cells cocultivated with gamma irradiated marrow stromal cell lines
    J S Greenberger
    Department of Radiation Oncology, University of Massachusetts Medical Center, Worcester 01655
    Leukemia 6:626-33. 1992
    ..M-CSF) released by irradiated stromal cells, and transient hematopoietic cell surface expression of MAC-1, and c-fms (M-CSF receptor)]; and (iii) a third stage of factor-independence...
  42. pmc Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells
    T Inaba
    3rd Department of Internal Medicine, University of Tokyo, Japan
    Mol Cell Biol 16:2264-73. 1996
    The macrophage colony-stimulating factor receptor encoded by the c-fms gene is expressed in vascular intimal smooth muscle cells isolated from atherosclerotic lesions...
  43. ncbi Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss
    Teruko Honda
    Department of Histology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Mol Immunol 42:1-8. 2005
    The M-CSF and its receptor (M-CSFR, CSF-1R or c-fms proto-oncogene) system were initially implicated as essential in mammals for normal monocyte development as well as for pregnancy...
  44. pmc Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta
    Ya Guang Liu
    Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Mol Hum Reprod 15:665-73. 2009
    ..the effects of TGF-beta1 on (i) the expression of macrophage colony-stimulating factor receptor encoded by the c-fms gene, (ii) transmesothelial invasiveness of endometrial cells, (iii) cellular proliferation and (iv) attachment to ..
  45. doi Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis
    Marc Baud'huin
    INSERM, UMR S 957, Nantes F 44035, France
    J Pathol 221:77-86. 2010
    ..proliferation, and survival, acting via the macrophage-colony stimulating factor receptor (M-CSF receptor, c-fms)...
  46. ncbi Suppressive effect of beta-carotene on the development of pulmonary foam cells in rats with hyper beta-lipoproteinemia
    K Shibuya
    Nippon Institute for Biological Science, Tokyo, Japan
    Toxicol Pathol 23:47-55. 1995
    ..The percentages of foamy, lipid-ingested monocytes (FMs) to the number of blood monocytes (BMs), the number and size of lipid droplets in FMs, the percentages of PFCs to ..
  47. pmc Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation
    Caroline Bourgin
    Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, 69622 Villeurbanne Cedex, France
    Mol Cell Biol 22:3744-56. 2002
    ..differentiation, Mona is induced and interacts with the macrophage colony-stimulating factor receptor, M-CSFR (also called Fms), suggesting that Mona could be involved in developmental signaling downstream of the M-CSFR by ..
  48. ncbi Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown
    T Hartmann
    Centre de Biochimie, CNRS, Nice, France
    Growth Factors 2:289-300. 1990
    The human CSF-1 receptor (c-fms protooncogene product) was introduced into CSF-1-unresponsive Chinese hamster lung fibroblasts (CCL39 cell line) in order to study its coupling to biochemical signal-transducing systems and to compare the ..
  49. ncbi Expression of functional human CSF-1 receptors on mouse bone marrow erythroid progenitor cells
    G Mouchiroud
    , UMR CNRS 106, , Villeurbanne, France
    C R Acad Sci III 316:1290-6. 1993
    ..cell line could proliferate in response to CSF-1 after retroviral transfer of human CSF-1 receptor (CSF-1R) gene (c-fms) without loss of the erythroid differentiation potential...
  50. ncbi [Clinical features of familial multiple sclerosis in Spain]
    M J Fernández-Pérez
    Servicio de Neurologia, Hospital Universitario Virgen Macarena, Sevilla, Espana
    Rev Neurol 29:693-6. 1999
    ..The real frequency and clinical features of familial MS is although not well established in Spain...
  51. ncbi [Effect of gemcitabine on granulocyte colony-stimulating factor receptor and bcr/abl mRNA in patients with chronic myeloid leukemia]
    Dan Liu
    Department of Hematology, Zhengzhou University First Hospital, and Research Center of Stem Cells, Zhengzhou University Basic Medical College, Zhengzhou 450052, Henan Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1168-71. 2010
    ..was purposed to investigate the effect of gemcitabine (GEM) on granulocyte colony-stimulating factor receptor (G-CSFR) and bcr/abl mRNA in patients with chronic myeloid leukemia (CML)...
  52. ncbi Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes
    Yue Xie
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:4687-98. 2003
    ..two adjacent sequences located within the N-terminal half of the protein that mediate the repression of c-fos and c-fms. One region (NF) appears to be involved in quenching transcriptional activation factors on target promoters and ..
  53. ncbi Receptor for macrophage colony-stimulating factor transduces a signal decreasing erythroid potential in the multipotent hematopoietic EML cell line
    G Pawlak
    Centre de Genetique Moleculaire et Cellulaire, UMR CNRS 5534, Universite Claude Bernard Lyon I, Villeurbanne, France
    Exp Hematol 28:1164-73. 2000
    ..lineage choice in pluripotent progenitor cells, we investigated the effects of macrophage colony-stimulating factor (M-CSF) on erythroid and myeloid potentials of multipotent EML cells ectopically expressing M-CSF receptor (M-CSFR).
  54. ncbi Osteoclast deficiency results in disorganized matrix, reduced mineralization, and abnormal osteoblast behavior in developing bone
    Xu Ming Dai
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Bone Miner Res 19:1441-51. 2004
    ..We therefore examined the micro- and ultrastructure of the developing bones of osteoclast-deficient CSF-1R-nullizygous mice (Csf1r(-/-) mice).
  55. ncbi Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces the osteoblastic differentiation of the human osteosarcoma cell line SaOS-2
    L Postiglione
    Dipartimento di Biologia e Patologia Cellulare, e Molecolare L Califano, Italy
    Calcif Tissue Int 72:85-97. 2003
    ..differentiation of hematopoietic cells through the interaction with a specific heterodimeric receptor complex (GM-CSFR), consisting of an alpha and a beta chain with molecular weights of 80 and 120 KDa, respectively...
  56. ncbi A novel approach for a water-soluble long-acting insulin prodrug: design, preparation, and analysis of [(2-sulfo)-9-fluorenylmethoxycarbonyl](3)-insulin
    E Gershonov
    Departments of Biological Chemistry and Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    J Med Chem 43:2530-7. 2000
    ..To this end, we have prepared (9-fluorenylmethoxycarbonyl-SO(3)H)(3)-insulin ((FMS)(3)-insulin), a derivative having three 9-fluorenylmethoxycarbonyl-SO(3)H (FMS) moieties covalently linked to the ..
  57. doi IL-17A suppresses the expression of bone resorption-related proteinases and osteoclast differentiation via IL-17RA or IL-17RC receptors in RAW264.7 cells
    Satoshi Kitami
    Department of Oral Health Sciences, Nihon University School of Dentistry, 1 8 13 Kanda Surugadai, Chiyoda ku, Tokyo, Japan
    Biochimie 92:398-404. 2010
    ..also on the expression of carbonic anhydrase II (CA II), cathepsin K, matrix metalloproteinases-9 (MMP-9), RANK, c-fms, and IL-17 receptors in these cells. The cells were cultured with or without 0.1, 1...
  58. pmc Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells
    A Rambaldi
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    J Clin Invest 81:1030-5. 1988
    ..The effects of CSF-1 are mediated through binding to specific, high-affinity surface receptors encoded by the c-fms gene...
  59. pmc Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes
    M A Reddy
    Department of Microbiology, Duke University Medical Center, Durham, North Carolina 27710
    J Exp Med 180:2309-19. 1994
    The receptor for macrophage colony stimulating factor (CSF-1), the c-fms gene product, is a key determinant in the differentiation of monocytic phagocytes...
  60. ncbi Increasing c-FMS (CSF-1 receptor) expression decreases retinoic acid concentration needed to cause cell differentiation and retinoblastoma protein hypophosphorylation
    A Yen
    Department of Pathology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Cancer Res 57:2020-8. 1997
    Increasing the expression of c-FMS (colony-stimulating factor 1 receptor) by introduction of a transgene reduced the concentration of retinoic acid or 1,25-dihydroxy vitamin D3 needed to cause myeloid or monocytic cell differentiation ..
  61. ncbi Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis
    Faisel M Abu-Duhier
    Academic Unit of Haematology, Division of Genomic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Br J Haematol 120:464-70. 2003
    ..conformation sensitive gel electrophoresis (CSGE) for mutations in the C-KIT gene (60 patients), as well as the C-FMS and FLT3 genes (40 patients)...
  62. ncbi Granulocyte colony-stimulating factor/granulocyte colony-stimulating factor receptor biological axis promotes survival and growth of bladder cancer cells
    Arup Chakraborty
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Urology 69:1210-5. 2007
    ..express both granulocyte colony-stimulating factor (G-CSF) and granulocyte colony-stimulating factor receptor (G-CSFR). We sought to determine whether G-CSF/G-CSFR signaling promotes survival and growth of bladder cancer cells...
  63. ncbi Macrophage priming and activation during fibrosarcoma growth: expression of c-myb, c-myc, c-fos, and c-fms
    D G Alleva
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061 0406
    Immunol Invest 23:457-72. 1994
    ..Unstimulated peritoneal M phi from tumor-bearing hosts (TBH) constitutively expressed the proto-oncogenes c-fms, c-fos, c-myc, and c-myb, whereas normal host (NH) M phi had little or no expression of these proto-oncogenes...
  64. ncbi Heterogeneity among cells that express osteoclast-associated genes in developing bone
    R Jemtland
    Massachusetts General Hospital, and the Department of Medicine, Harvard Medical School, Boston 02114, USA
    Endocrinology 139:340-9. 1998
    ..by osteoclasts, tartrate-resistant acid phosphatase (TRAP), type IV collagenase (matrix metalloproteinase-9), and c-fms, the receptor for macrophage colony-stimulating factor...
  65. ncbi Bivalent binding and signaling characteristics of Leridistim, a novel chimeric dual agonist of interleukin-3 and granulocyte colony-stimulating factor receptors
    J B Monahan
    Discovery Research, Pharmacia Corporation, 700 Chesterfield Village Parkway, Chesterfield, MO 63017, USA
    Exp Hematol 29:416-24. 2001
    ..of both interleukin-3 (IL-3) receptors (IL-3R) and granulocyte colony-stimulating factor (G-CSF) receptors (G-CSFR)...
  66. ncbi Granulocyte colony-stimulating factor receptor signals for beta1-integrin expression and adhesion in bladder cancer
    Arup Chakraborty
    Department of Pediatrics, Section of Leukocyte Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Urology 63:177-83. 2004
    To examine the association of granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor (G-CSFR) expression with increased beta1-integrin expression and determine the ability of autocrine G-CSFR signaling to promote bladder cancer ..
  67. ncbi Requirements for transformation by the fms oncogene product (CSF-1 receptor)
    C W Rettenmier
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Princess Takamatsu Symp 17:211-8. 1986
    The c-fms proto-oncogene product is a transmembrane glycoprotein that is probably identical to the cell surface receptor for the mononuclear phagocyte colony stimulating factor, CSF-1...
  68. pmc Expression of granulocyte colony stimulating factor receptor in human colorectal cancer
    X Yang
    Medical College, Nanjing University, Jingsu, China
    Postgrad Med J 81:333-7. 2005
    To discover if human colorectal cancer expresses granulocyte colony stimulating factor receptor (G-CSFR) and if granulocyte colony stimulating factor (G-CSF) plays an important part in the development and progression of human colorectal ..
  69. pmc Bordetella pertussis isolates in Finland: serotype and fimbrial expression
    Eriikka Heikkinen
    Pertussis Reference Laboratory, National Public Health Institute, Kiinamyllynkatu 13, 20520 Turku, Finland
    BMC Microbiol 8:162. 2008
    ..B. pertussis has three distinct serotypes Fim2, Fim3 or Fim2,3. Generally, B...
  70. ncbi A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model
    Hiroaki Ohno
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, 3 Miyahara, Takasaki, Gunma, 370 1295, Japan
    Mol Cancer Ther 5:2634-43. 2006
    ..In this study, we investigated whether an inhibitor of M-CSF receptor (c-Fms) suppresses osteoclast-dependent osteolysis in bone metastatic lesions...
  71. ncbi Molecular genetic aspects of myelodysplastic syndromes
    C R Bartram
    Department of Pediatrics II, University of Ulm, Germany
    Hematol Oncol Clin North Am 6:557-70. 1992
    ..Mutations in the FMS gene, encoding the CSF-1 receptor, are found in 16% of cases...
  72. ncbi Proteolytic cleavage of granulocyte colony-stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony-stimulating factor receptor
    Melissa G Hunter
    Bone Marrow Transplant Program, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    Am J Hematol 74:149-55. 2003
    ..syndromes prompted us to investigate whether granulocyte colony-stimulating factor (G-CSF) and its receptor (G-CSFR) are also substrates for NE...
  73. pmc Management of fibromyalgia syndrome--an interdisciplinary evidence-based guideline
    Winfried Häuser
    Department of Internal Medicine I, Klinikum Saarbrücken, Germany
    Ger Med Sci 6:Doc14. 2008
    The prevalence of fibromyalgia syndrome (FMS) of 1-2% in the general population associated with high disease-related costs and the conflicting data on treatment effectiveness had led to the development of evidence-based guidelines ..
  74. doi The role of urinary soluble endoglin in the diagnosis of pre-eclampsia: comparison with soluble fms-like tyrosine kinase 1 to placental growth factor ratio
    C S Buhimschi
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University, New Haven, CT 06520, USA
    BJOG 117:321-30. 2010
    ..of angiogenic factors, we sought to determine the clinical utility of urinary soluble endoglin, relative to the soluble fms-like tyrosine kinase 1 to placental growth factor (PlGF) ratio, in the diagnosis of PE during gestation.
  75. ncbi Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
    T Graven-Nielsen
    Center for Sensory Motor Interaction, Laboratory for Experimental Pain Research, Aalborg University, Fredrik Bajers Vej 7D 3, DK 9220, Aalborg, Denmark
    Pain 85:483-91. 2000
    ..muscle pain and temporal summation of muscular nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study assessed the effects of an NMDA-antagonist (ketamine) on these central mechanisms...
  76. ncbi [Expression of G-CSF and GM-CSF receptors on CD34 positive cells in aplastic anemia and myelodysplastic syndrome patients and its significance]
    Hong Zhi Xu
    Department of Hematology, Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1308-11. 2008
    ..aimed to detect the ratio of CD34+ cells in bone marrow mononuclear cells (BMMNCs) and the expression rate of G(M)-CSFR on CD34+ cells in bone marrow of the patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS)...
  77. ncbi Granulocyte colony-stimulating receptor promotes beta1-integrin-mediated adhesion and invasion of bladder cancer cells
    Arup Chakraborty
    Section of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Urology 68:208-13. 2006
    To determine whether granulocyte colony-stimulating factor receptor (G-CSFR) autocrine signaling promotes endothelial cell adhesion and invasion of bladder cancer cells through a beta1-integrin-mediated pathway...
  78. doi The efficacy of balneotherapy and physical modalities on the pulmonary system of patients with fibromyalgia
    Nur Kesiktas
    Physical Medicine and Rehabilitation Department Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
    J Back Musculoskelet Rehabil 24:57-65. 2011
    Effects of balneotherapy on Primary Fibromyalgia Syndrome (FMS) have been studied well, except for its effect on the respiratory symptoms of FMS...
  79. ncbi Deletion of c-ets1 and T3 gamma loci from the 11q- chromosome in the human monoblastic cell line U937
    J Shipley
    Imperial Cancer Research Fund, London
    Leuk Res 13:445-50. 1989
    ..There was also no detectable rearrangement in the c-fms gene which was shown to be translocated from chromosome 5 to chromosome 1 in a subline of U937...
  80. ncbi Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways
    S Tanaka
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 270:14347-51. 1995
    ..These results suggest that c-Cbl is involved in the signaling pathways utilized by different types of tyrosine kinases...
  81. ncbi Removal of fragrance materials during U.S. and European wastewater treatment
    Staci L Simonich
    The Procter and Gamble Company, Product Safety and Regulatory Affairs, Cincinnati, Ohio 45217 1087, USA
    Environ Sci Technol 36:2839-47. 2002
    ..average FM profile in primary effluent was similar to the average influent profile; however, the concentration of FMs was reduced by 14.6-50.6% in primary effluent...
  82. ncbi The influence of computer-assisted instruction on acquiring early skills in intraoral radiography
    W Bruce Howerton
    Department of Diagnostic Sciences and General Dentistry, University of North Carolina School of Dentistry, Chapel Hill, NC 27599 7450, USA
    J Dent Educ 66:1154-8. 2002
    ..was to determine if there was a significant difference in the diagnostic quality of the initial full-mouth series (FMS) exposed by first-year dental students after viewing a Computer Assisted Instruction (CAI) module on radiographic ..
  83. ncbi Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype
    N Matsuno
    Department of Internal Medicine II, Kumamoto University School of Medicine, Japan
    Leukemia 17:2492-9. 2003
    ..tandem duplications (ITDs) in the juxtamembrane domain and mutations in the second tyrosine kinase domain of the Fms-like tyrosine kinase 3 (FLT3) gene represent the most frequent genetic alterations in AML...
  84. ncbi Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutation
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 83:301-8. 2006
    ..b>FMS-like receptor tyrosine kinase 3 (FLT3), together with KIT, FMS, and platelet-derived growth factor receptor, is a ..
  85. ncbi Osteoclastic activity induces osteomodulin expression in osteoblasts
    Ken Ninomiya
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 362:460-6. 2007
    ..OMD expression in op/op mice was upregulated by M-CSF treatment. Since the M-CSF receptor c-Fms was not expressed in osteoblasts, it is likely that OMD is an osteoblast maturation marker that is induced by ..
  86. doi How should women with pre-eclampsia be followed up? New insights from mechanistic studies
    Alexandre Hertig
    Department of Nephrology and Renal Transplantation, Hopital Tenon, Paris, France
    Nat Clin Pract Nephrol 4:503-9. 2008
    ..Specifically, the notion has emerged that the placenta is a source of antiangiogenic factors, such as soluble fms-like tyrosine kinase 1, that can progressively impair the mother's vascular and glomerular function throughout ..
  87. doi Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
    Dirk Schmidt-Arras
    Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Friedrich Schiller University Jena, Jena, Germany
    Blood 113:3568-76. 2009
    The mechanism of cell transformation by Fms-like tyrosine kinase 3 (FLT3) in acute myeloid leukemia (AML) is incompletely understood...
  88. pmc Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity
    Anjali Verma
    Department of Pediatrics and Developmental Vascular Biology Program, Medical College of Wisconsin and Children s Research Institute, Milwaukee, WI 53226, USA
    Blood 115:4614-22. 2010
    ..ECSCR-silenced cells show reduced VEGF-induced phosphorylation of KDR but not of FMS-like tyrosine kinase 1 (FLT1)/VEGF receptor 1...
  89. doi Relationship between core stability, functional movement, and performance
    Tomoko Okada
    Exercise Physiology Laboratory, Athletic Training Department, Indiana State University, Terre Haute, Indiana
    J Strength Cond Res 25:252-61. 2011
    ..core stability (flexion [FLEX], extension [EXT], right and left lateral [LATr/LATl]), functional movement screen (FMS) (deep squat [DS], trunk-stability push-up [PU], right and left hurdle step [HSr/HSl], in-line lunge [ILLr/ILLl], ..
  90. doi New prognostic markers in acute myeloid leukemia: perspective from the clinic
    James M Foran
    Division of Hematology Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hematology Am Soc Hematol Educ Program 2010:47-55. 2010
    ..molecular diagnostics has heralded an explosion in new prognostic factors, including gene mutations in KIT, FLT3 (Fms-like tyrosine kinase 3), NPM1 (nucleophosmin 1), and CEBPA (CCAAT enhancer-binding protein-α)...
  91. pmc A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice
    Zhongbin Lai
    Department of Pediatrics, Women and Infants Hospital Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
    Hypertension 57:505-14. 2011
    ..Hypoxic exposure caused marked elevation of soluble fms-like tyrosine kinase 1 (110.8 ± 20.1 versus 44.7 ± 11...
  92. doi Respiratory symptoms, perceived air quality and physiological signs in elementary school pupils in relation to displacement and mixing ventilation system: an intervention study
    D Norback
    Department of Medical Science, Uppsala University, Occupational and Environmental Medicine, University Hospital, SE, Sweden
    Indoor Air 21:427-37. 2011
    ..ventilation to two types of displacement ventilation, front ventilation system (FVS) and floor master system (FMS). The study included pupils in three elementary school classes (N = 61), all with floor heating...
  93. pmc The effect of maternal soluble FMS-like tyrosine kinase 1 during pregnancy on risk of preterm delivery
    Jennifer K Straughen
    Department of Family Medicine and Public Health Sciences, the Wayne State University School of Medicine, Detroit, MI, USA
    J Matern Fetal Neonatal Med 25:1879-83. 2012
    Soluble fms-like tyrosine kinase 1 (sFlt1) is an antiangiogenic protein that is associated with a number of disorders of placental angiogenesis...
  94. pmc Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women
    Kristina L Makey
    Cancer Institute, and Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Eur J Cancer Prev 22:83-9. 2013
    ..reported previously that exercise induced a circulating angiostatic phenotype characterized by increased soluble fms-like tyrosine kinase-1 (sFlt-1) and endostatin and decreased unbound vascular endothelial growth factor (VEGF) in ..
  95. pmc The influence of overweight and obesity on maternal soluble fms-like tyrosine kinase 1 and its relationship with leptin during pregnancy
    Jennifer K Straughen
    Department of Family Medicine and Public Health Sciences, Division of Population Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA
    Reprod Sci 20:269-75. 2013
    We studied obesity-related differences in the relation of maternal levels of leptin to levels of soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein that influences placentation and risk of adverse pregnancy outcomes...
  96. doi The role of hypoxia and hypoxia-inducible factor-1alpha in preeclampsia pathogenesis
    Reshef Tal
    Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York 11219, USA
    Biol Reprod 87:134. 2012
    ..Clinical and experimental evidence implicating the circulating antiangiogenic molecules soluble Fms-like tyrosine kinase-1 (sFLT-1) and soluble endoglin (sENG), as well as endothelin-1 and the angiotensin II ..
  97. doi Influence of cortisol and DHEA-S on pain and other symptoms in post menopausal women with fibromyalgia
    Rodrigo Pegado de Abreu Freitas
    Department of Physiology, Graduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, Brazil
    J Back Musculoskelet Rehabil 25:245-52. 2012
    This study aims to assess cortisol and dehydroepiandrosterone sulfate (DHEA-S) levels in post-menopausal women with FMS and correlate it with pain threshold and tolerance, depression and quality of life.
  98. doi Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells
    Sofia Helmersson
    Immunology Group, Section for Immunology, Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden
    Am J Pathol 182:1671-80. 2013
    ..In mice with established experimental autoimmune encephalomyelitis, the numbers of Ly6C(hi) CD115(+) inflammatory monocytes and CD11b(+)CD11c(+) dendritic cells (DCs) were reduced in spleen, but not in bone ..
  99. doi Dendritic cell homeostasis is maintained by nonhematopoietic and T-cell-produced Flt3-ligand in steady state and during immune responses
    Yasuyuki Saito
    Division of Hematology, University Hospital Zurich, Zurich, Switzerland
    Eur J Immunol 43:1651-8. 2013
    ..b>Fms-related tyrosine kinase 3 is expressed during cellular development from hematopoietic progenitors to lymphoid-..
  100. doi Effects of pravastatin on angiogenic and placental hypoxic imbalance in a mouse model of preeclampsia
    Antonio F Saad
    1Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Reprod Sci 21:138-45. 2014
    ..Pra) on angiogenic and placental hypoxic imbalance in a model of preeclampsia induced by overexpression of soluble fms-like tyrosine kinase 1 (sFlt-1), we randomly allocated pregnant CD1 mice to injection with adenovirus-carrying sFlt-..
  101. doi Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells
    Carla Garcia-Morales
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Dev Comp Immunol 42:278-85. 2014
    ..avian macrophages proliferate and differentiate in response to CSF1 and IL34, acting through the shared receptor, CSF1R. CSF1R mRNA expression in the chicken is restricted to macrophages and their progenitors...

Research Grants67

  1. IVMT for Fibromyalgia Syndrome: A Pilot Study
    David Katz; Fiscal Year: 2004
    Fibromyalgia syndrome (FMS) is a prevalent and debilitating condition for which definitive therapy is lacking and urgently needed...
  2. Longitudinal Determination of Outcomes of Adolescents with Fibromyalgia
    Susmita Kashikar-Zuck; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Fibromyalgia syndrome (FMS) is a chronic and often debilitating condition that results in marked difficulties in daily functioning, psychiatric comorbidity and decreased quality of life...
  3. Lifestyle Modification Program for Overweight and Obese Fibromyalgia Patients
    Akiko Okifuji; Fiscal Year: 2010
    ..program to improve weight and symptom management in overweight and obese patients with fibromyalgia syndrome (FMS)...
  4. Supraspinal Modulation of Nociceptive Reactions in Fibromyalgia
    JAMIE LYNN RHUDY; Fiscal Year: 2010
    Fibromyalgia syndrome (FMS) is an insidious disease that results in disability for 70% of those who suffer from it and tremendous loss of work and productivity. It is estimated that 8-12 million adults in the U.S...
  5. A Pilot Study on the Combined Use of Cognitive Behavioral Therapy (CBT) and Dulox
    DENNIS CHUA ANG; Fiscal Year: 2010
    Fibromyalgia (FMS), defined as the presence of both chronic widespread pain and the finding of 11/18 tender points on examination, affects 2% of the general population...
  6. EXERCISE INDUCED CHANGES IN HPA ACTIVITY IN FIBROMYALGIA
    Patricia Deuster; Fiscal Year: 2003
    Five to 10 percent of patients entering general practice centers report symptoms of fibromyalgia syndrome (FMS), a painful and debilitating condition of the musculoskeletal system...
  7. NURSING STUDY OF SLEEP AND FIBROMYALGIA IN MIDLIFE WOMEN
    Carol Landis; Fiscal Year: 1999
    Fibromyalgia syndrome (FMS) is estimated to affect about 5% of all Americans, is the third most common rheumatic condition, and accounts for 15 to 40% of referrals to rheumatologists...
  8. Optimizing Fibromyalgia Self-Management
    Daniel Rooks; Fiscal Year: 2006
    Fibromyalgia syndrome (FMS) is a common, chronic musculoskeletal disorder and a growing cause of disability and increased health care utilization...
  9. Vagus Nerve Stimulation in Fibromyalgia
    Gudrun Lange; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Fibromyalgia Syndrome (FMS) is a chronic pain disorder of unknown origin, characterized by diffuse body pain and tenderness...
  10. NEUROTROPHINS AND AN ANIMAL MODEL OF FIBROMYALGIA
    ALICE LARSON; Fiscal Year: 2003
    DESCRIPTION (taken from the application): Fibromyalgia syndrome (FMS) is characterized by pain throughout the body (multifocal) with specific areas that are particularly sensitive to pressure...
  11. AUTONOMIC STRESS REACTIVITY IN FIBROMYALGIA
    Akiko Okifuji; Fiscal Year: 2001
    ..the relationship between autonomic stress-reactivity and pain sensitivity in patients with fibromyalgia syndrome (FMS)...
  12. FIBROMYALGIA, DEPRESSION AND MYOFASCIAL TMD
    Karen Raphael; Fiscal Year: 2002
    DESCRIPTION (taken from the application): The well-established comorbidity of fibromyalgia (FMS) and major depression (MDD) has motivated speculations about the direction of the relationship...
  13. Maximizing Exercise for Persons with Fibromyalgia
    Daniel Rooks; Fiscal Year: 2004
    Fibromyalgia (FMS) is a common, chronic musculoskeletal disorder and a growing cause of disability and medical care costs. With a poorly understood etiology and no known cure, current pharmacological treatment is mostly ineffective...
  14. MAPPING GENES FOR FIBROMYALGIA SYNDROME
    Jane Olson; Fiscal Year: 2000
    ..contract is to support a core facility dedicated to the collection and characterization of Fibromyalgia syndrome (FMS) families, uni and multiplex for FMS. The facility will operate two simultaneous activities...
  15. Modeling preeclampsia in mice with inducible placenta-specific gene expression
    Nihar R Nayak; Fiscal Year: 2012
    ..studies in rodents, it has been suggested that the abnormal elevation of the circulating levels of soluble fms-like tyrosine kinase 1 (sFlt- 1) contributes to the systemic endothelial dysfunction and clinical manifestations of ..
  16. Kenneth I Ataga; Fiscal Year: 2016
    ..levels of both soluble vascular cell adhesion molecule-1 (VCAM-1), a measure of endothelial activation, and soluble fms-like tyrosine kinase-1 (sFLT-1), a member of the VEGF receptor family...
  17. Hypertensive Mechanisms in Preeclampsia
    ERIC MATTHEW GEORGE; Fiscal Year: 2013
    ..In recent years, a great deal of attention has been focused on the secretion of an anti- angiogenic protein, the fms-like tyrosine kinase-1 (sFlt-1)...
  18. Jean F Regal; Fiscal Year: 2015
    ..including autoantibodies to angiotensin II type I receptor (AT1-AA) and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 despite the observation that many women do not present with increases in either...
  19. SHALINI THERESE LOW-NAM; Fiscal Year: 2014
    ..on signal strength, character and duration of signaling from the macrophage colony stimulating factor receptor (M-CSFR)...
  20. Sanjay Rajagopalan; Fiscal Year: 2014
    ..yellow fluorescent protein expression, under the control of a macrophage colony stimulating factor receptor (CD115, c-fms) promoter...
  21. Raouf A Khalil; Fiscal Year: 2016
    ..Also, RUPP is associated with increased plasma levels of soluble fms-like tyrosine kinase-1 (sFlt-1), and chronic elevation of sFlt-1 in pregnant rats causes increases in BP...
  22. Sarosh Rana; Fiscal Year: 2014
    ..There is accumulating evidence that anti- angiogenic proteins (soluble fms-like tyrosine kinase-sFlt1 and soluble endoglin-sEng) are elevated, while levels of pro-angiogenic proteins (..
  23. SHIP PROTEINS AND SIGNAL TRANSDUCTION
    LARRY ROHRSCHNEIDER; Fiscal Year: 2003
    The M-CSF (macrophage colony stimulating factor) receptor, Fms, regulates the growth and development of the monocyte-macrophage lineage of blood cells...
  24. Iris Z Jaffe; Fiscal Year: 2016
    ..vascular cell proliferation, monocyte chemotaxis, and inflammation by binding to the transmembrane receptor, fms-like tyrosine kinase (Flt-1)...
  25. Engineering the Brain Immune System for Tumor Therapy
    Maria G Castro; Fiscal Year: 2013
    ..Specifically, expression of fms-like tyrosine kinase 3 ligand (Flt3L) recruits antigen presenting cells (e.g...
  26. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..glioma model a combined gene therapy approach using first generation recombinant adenovirus vectors expressing fms-like tyrosine kinase 3 ligand (FltSL) (to recruit DCs to the brain), and herpes simplex virus type 1 thymidine ..
  27. Kira Gritsman; Fiscal Year: 2014
    ..as it is activated by hematopoietic growth factor receptors, such as erythropoietin receptor, c-kit receptor, and fms-like tyrosine kinase 3 (FLT3)...
  28. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..the Notch delta like ligand (OP9-DL1) along with cytokines (IL-7), and growth factors (stem cell factor [SCF], fms-like tyrosine- kinase 3 [Flt3] ligand). We will examine cell growth, development, and phenotypic changes over time...
  29. Plerixafor/G-CSF with Sorafenib for Acute Myelogenous Leukemia with FLT3-ITD Muta
    MICHAEL W ANDREEFF; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The prognosis of patients with relapsed AML harboring Fms-like tyrosine kinase 3 gene (FLT3) mutations is extremely poor...
  30. Reuben Kapur; Fiscal Year: 2015
    ..an in-frame mutation leading to insertion or duplication of several amino acids near the juxtamembrane domain, in fms-like tyrosine kinase receptor (FLT3), are seen in nearly 25% of all AML patients and confer a poor prognosis...
  31. Costica Aloman; Fiscal Year: 2015
    ..DC development and activity can be amplified by the protein fms-like tyrosine kinase 3 ligand (Flt3L), which has already been tested in humans as cancer immunotherapy...
  32. Improved Therapies for AML in the Elderly
    SARAH C NABINGER; Fiscal Year: 2011
    ..One of the most commonly mutated genes in AML is FMS-like Tyrosine Kinase Receptor (Flt3)...
  33. Transcriptional Regulation of Lympho-Myeloid Development
    Rodney Dekoter; Fiscal Year: 2007
    ..gene (IL- 7R_) in developing lymphoid cells, and for the macrophage colony-stimulating factor receptor gene (M- CSFR, encoded by c-fms) in developing myeloid cells. Taken together, this evidence suggests that PU...
  34. PETER J HEINZELMAN; Fiscal Year: 2014
    ..Specifically, we will evolve variants with highly pH- sensitive G-CSF receptor (G-CSFR) binding affinity...
  35. DAP12 and ITAM-signals in Osteoclastogenesis
    Mary C Nakamura; Fiscal Year: 2013
    ..Osteoclast development requires receptor stimulation through RANK (receptor for activation of NFkappaB), and c-fms (receptor for macrophage colony stimulating factor, M-CSF)...
  36. Structural biology of oncogenic receptor tyrosine kinases
    Xiaolin He; Fiscal Year: 2010
    ..III RTKs, such as the Stem Cell Factor (SCF) receptor KIT, the Macrophage Colony Stimulating Factor (MCSF) receptor FMS, and the FLT3 Ligand (FLT3L) receptor FLT3, contribute to the genesis and development of many types of cancers such ..
  37. Microglial Neuroprotection and Neurotoxicity
    Greer Murphy; Fiscal Year: 2007
    ..M-CSF expression is increased in AD and in the PDAPP transgenic mouse model for AD. The M-CSF receptor (M-CSFR) is increased on microglia in AD, in the PDAPP mouse, and in experimental models for brain injury...
  38. DEVELOPMENT OF GM-CSF ANTOGONISTS
    William Williams; Fiscal Year: 1993
    ..GM-CSF binds to specific cellular receptors (GM-CSFR) which belong to a recently described supergene family...
  39. SUBGROUPS OF FMS--SYMPTOMS, BELIEFS & TAILORED TREATMENT
    DENNIS TURK; Fiscal Year: 2009
    DESCRIPTION: Fibromyalgia Syndrome (FMS) adversely affects patient lives and they are high utilizers of health care. Exercise programs have demonstrable in benefit for FMS patients...
  40. Exercise-based Motivational Interviewing for Fibromyalgia
    DENNIS CHUA ANG; Fiscal Year: 2010
    Fibromyalgia (FMS), defined as the presence of both chronic widespread pain and the finding of 11/18 tender points on examination, affects 2% of the general population...
  41. Health Promotion for Women with Fibromyalgia
    Alexa Stuifbergen; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Women with chronic disabling conditions such as fibromyalgia syndrome (FMS) must manage a wide variety of disease-related, intrapersonal, and environmental demands to maintain their health and ..
  42. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..mice expressing yellow fluorescent protein (YFP) under the control of monocyte-macrophage specific promoter (c-fms, c-fmsYFP) to ambient PM2...
  43. Cong Yan; Fiscal Year: 2015
    ..This will be accomplished by overexpressing dnPPAR? in myeloid cells to inhibit the endogenous PPAR? function in c-fms-rtTA/(tetO)7-dnPPAR? bitransgenic mice to promote chronic inflammation and lung cancer...
  44. Lisa M Coussens; Fiscal Year: 2015
    ..or in combination with targeted blockade of EGF receptor (EGFR) or colony stimulating factor (CSF)-1 receptor (CSF1R) kinases...
  45. Astrid E Cardona; Fiscal Year: 2016
    ..demyelination is enhanced CX3CR1-deficient mice, 2) absence of CX3CR1 correlated with a selective accumulation of CD115+CD11c+ dendritic cells to CNS tissues, and 3) Bone marrow chimeric mice revealed that absence of CX3CR1 in bone ..
  46. Hematopoietic Stem Cell Differentiation to Macrophages
    E Richard Stanley; Fiscal Year: 2013
    ..therefore, the similar phenotypes of CSF-1-deficient Csf1op/Csf1op and CSF-1R tyrosine kinase (c-Fms)-nullizygous (Csf1r-/-) mice are pleiotropic...
  47. ELANE and CSF3R mutations in severe congenital neutropenia
    Fan Dong; Fiscal Year: 2012
    ..leukemia (AML) and progression from SCN to AML is associated with mutations in CSF3R encoding the G-CSF receptor (G-CSFR), which lead to C-terminal truncation of the receptor...
  48. Maintenance of the Hematopoietic Stem Cell Niche Monocytes and Macrophages
    Andrew Chow; Fiscal Year: 2012
    ..This application proposes to study the role of the M-CSF receptor (CD115)-expressing cells in the maintenance of the HSC niche...
  49. Negative Regulation of Osteoclastogenesis by Inflammatory Signals
    Kyung Hyun Park-Min; Fiscal Year: 2013
    ..The mechanism of TLR-mediated inhibition involves induction of a M-CSF receptor (c-Fms) shedding and proteolytic processing by activated TNF-alpha converting enzyme (TACE, also known as ADAM-17), ..
  50. KLF4, myeloid development, and transplantation arteriosclerosis
    A K M KHYRUL WARA; Fiscal Year: 2010
    ..overexpression of KLF4 alone in the human promyelocytic cell line, HL-60, confers the morphologic, genetic (M-CSFR, CD11b, CD14), and functional (adhesion and phagocytosis) characteristics of a mature monocyte...
  51. Lionel B Ivashkiv; Fiscal Year: 2016
    ..Modulation of a proteolytic pathway that generates a biologically active intracellular fragment of the Fms receptor for M-CSF. 2...
  52. CLONAL DOMINANCE OF HEMATOPOIETIC STEM CELLS EXPRESSING MUTANT CSF3R
    Daniel C Link; Fiscal Year: 2013
    ..Truncation mutations of CSF3R, encoding the G-CSF receptor (G-CSFR), are common early mutations associated with leukemic progression in patients with SCN...
  53. ROLE OF CSF-1 IN OSTEOCLAST FUNCTION
    KARL LEONARD INSOGNA; Fiscal Year: 2013
    ..approach will be used to further clarify the function CSF1 in mature osteoclasts by deleting its receptor, c-fms, in these cells...
  54. Cell Specific Localization of Altered Gene Expression in Pulmonary Hypertension
    Marlene Rabinovitch; Fiscal Year: 2012
    ..expanded subpopulations of vascular cells in IPAH vs control lungs that are double positive for CD31+ and GM-CSFR[unreadable]+, or CD31+ and PDGFR[unreadable]+...
  55. Small wearable biosensor patch for continuous and painless alcohol monitoring
    JOSEPH MARCANIO; Fiscal Year: 2010
    ..Changes in the detection chemistry, if needed, will be made on the macro electrode. 2. Functionalize FMS chip. The existing chip platform will be functionalized to detect alcohol...
  56. Jesus Rivera-Nieves; Fiscal Year: 2015
    ..Supplementation with all-trans retinoic acid and administration of fms-like tyrosine ligand (FLT3L) significantly attenuated Ileitis, suggesting that IEC-derived RA was insufficient to ..
  57. RYAN BRENT DAY; Fiscal Year: 2014
    ..Preliminary studies of G-CSF receptor (G-CSFR)-/- bone marrow chimeras demonstrate that G-CSF-induced B cell suppression occurs in a non-cell intrinsic fashion...
  58. Auditory Neural Filters Studied with in vivo Whole-Cell Recordings.
    Joshua X Gittelman; Fiscal Year: 2010
    ..the extent to which 1C neurons are selective for the direction of FM, including the rate and intensity of the FMs. Second, I will determine whether and to what extent FM direction selectivity is created de novo in the 1C, or is ..
  59. Steven L Teitelbaum; Fiscal Year: 2016
    ..however, that the principal means by which M-CSF exerts its cytoskeletal effect is to prompt its receptor c-Fms to transmit intracellular signals to the cytoplasmic domain of the [unreadable]3 integrin subunit...
  60. GENETIC BASES FOR DISEASES OF THE RANK SIGNALING PATHWAY
    STEVEN R MUMM; Fiscal Year: 2013
    ..Modulators of RANK signaling will also be examined, including TRAIL, IL-1, MCSF, c-FMS and additional cytokines and their cognate receptors...
  61. PHARMACOLOGIC AND MOLECULAR CONTROL OF C-JUN IN LEUKEMIA
    MATTHEW SHERMAN; Fiscal Year: 1992
    ..monocytic lineage express both the macrophage-specific colony stimulating factor (M-CSF), and the M-CSF receptor (c-fms) genes...
  62. CSF-1 and c-fms and the Early Endometriotic Lesion
    Rajeshwar Rao Tekmal; Fiscal Year: 2010
    ..CSF-1 interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of several types of cancer...
  63. Stress and Neuroimmune Dysergulation in Chronic Fatigue Patients
    Kathleen Light; Fiscal Year: 2007
    ..healthy controls, and between patients with CFS vs. fibromyalgia (FMS)...
  64. Enzyme Activity Enhancement in Functionalized Nanoporous Support
    Chenghong Lei; Fiscal Year: 2012
    ..is based on the observations: First, we have entrapped three different enzymes in functionalized mesoporous silica (FMS). Mesoporous silica is a typical open nanoporous support with pore sizes as large as tens of nanometers...
  65. Machine learning to identify predictive SNPs and complex interaction effects
    Yue Wang; Fiscal Year: 2010
    ..a panel of most relevant existing methods;and (2) to apply SCA- HCIG method to the real SNP data of NIAMS-funded FMS cohort in relationship to metabolic syndrome etc...
  66. G-CSF Receptor and Ubiquitination
    Belinda Avalos; Fiscal Year: 2006
    ..The granulocyte colony-stimulating factor receptor (G-CSFR) plays a critical role in this process as the major regulator of myeloid cell proliferation and differentiation and ..
  67. REGULATION OF CSF 1 AND UROKINASE IN OVARIAN CANCER
    SETSUKO CHAMBERS; Fiscal Year: 1999
    The c-fms proto-oncogene encodes the receptor for a hematopoietic growth factor, CSF-1...