CRX

Summary

Gene Symbol: CRX
Description: cone-rod homeobox
Alias: CORD2, CRD, LCA7, OTX3, cone-rod homeobox protein, orthodenticle homeobox 3
Species: human

Top Publications

  1. ncbi Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    S Chen
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 19:1017-30. 1997
  2. ncbi Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
    C L Freund
    Department of Genetics, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 91:543-53. 1997
  3. ncbi Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
    P K Swain
    Department of Ophthalmology, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Neuron 19:1329-36. 1997
  4. ncbi De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
    C L Freund
    Nat Genet 18:311-2. 1998
  5. ncbi Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function
    A Swaroop
    Department of Ophthalmology, Program in Cellular and Molecular Biology, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Hum Mol Genet 8:299-305. 1999
  6. ncbi Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development
    L C Bibb
    Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Hum Mol Genet 10:1571-9. 2001
  7. ncbi Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function
    Xuejiao Wang
    Department of Ophthalmology and Visual Sciences, Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:43288-300. 2002
  8. ncbi The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 14:747-64. 2005
  9. doi The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults: a systematic review and economic model
    M Bond
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, UK
    Health Technol Assess 13:1-330. 2009
  10. ncbi Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, The University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:32728-36. 2004

Research Grants

  1. David J Shapiro; Fiscal Year: 2014
  2. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
  3. Coordination of Gene Expression in Retinal Development
    KENNETH MITTON; Fiscal Year: 2009
  4. KEVIN ROBERT VINCENT; Fiscal Year: 2014
  5. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
  6. RANDO L ALLIKMETS; Fiscal Year: 2014
  7. QUANTITATIVE ANALYSIS AND ENGINEERING OF THE PHOTORECEPTOR TRANSCRIPTION NETWORK
    Joseph C Corbo; Fiscal Year: 2012
  8. RANDO L ALLIKMETS; Fiscal Year: 2015
  9. Cell type-specific roles of Rb in retinal differentiation
    Michael A Dyer; Fiscal Year: 2012
  10. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. ncbi Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
    S Chen
    The Wilmer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Neuron 19:1017-30. 1997
    ..a bait containing the Ret 4 site from the bovine rhodopsin promoter, we have cloned a new member of the family, Crx (Cone rod homeobox)...
  2. ncbi Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
    C L Freund
    Department of Genetics, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 91:543-53. 1997
    ..homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13...
  3. ncbi Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
    P K Swain
    Department of Ophthalmology, W K Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA
    Neuron 19:1329-36. 1997
    b>Crx is a novel paired-like homeodomain protein that is expressed predominantly in retinal photoreceptors and pinealocytes. Its gene has been mapped to chromosome 19q13...
  4. ncbi De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
    C L Freund
    Nat Genet 18:311-2. 1998
  5. ncbi Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function
    A Swaroop
    Department of Ophthalmology, Program in Cellular and Molecular Biology, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105 0714, USA
    Hum Mol Genet 8:299-305. 1999
    The CRX (cone-rod homeobox) gene is specifically expressed in developing and mature photoreceptors and encodes an otd/Otx-like paired homeodomain protein...
  6. ncbi Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development
    L C Bibb
    Section of Cell and Molecular Biology, Imperial College School of Medicine, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, UK
    Hum Mol Genet 10:1571-9. 2001
    Cone--rod homeobox (CRX), a paired-like homeobox transcription factor, plays a major role in photoreceptor development and maintenance of the retina...
  7. ncbi Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function
    Xuejiao Wang
    Department of Ophthalmology and Visual Sciences, Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:43288-300. 2002
    b>Crx (cone-rod homeobox) is a homeodomain transcription factor implicated in regulating the expression of photoreceptor and pineal genes...
  8. ncbi The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes
    Guang Hua Peng
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 14:747-64. 2005
    ..Using yeast two-hybrid screens with Nr2e3 as bait, the cone-rod homeobox protein Crx was identified as an interacting partner of Nr2e3...
  9. doi The effectiveness and cost-effectiveness of cochlear implants for severe to profound deafness in children and adults: a systematic review and economic model
    M Bond
    Peninsula Technology Assessment Group PenTAG, Peninsula Medical School, Universities of Exeter and Plymouth, UK
    Health Technol Assess 13:1-330. 2009
    ....
  10. ncbi Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, The University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:32728-36. 2004
    ..recombinant fragments of SP-D that are composed of the alpha-helical coiled-coil neck region and three CRDs (SP-D(n/CRD)) or SP-D(n/CRD) with eight GXY repeats (SPD(GXY)(8)(n/CRD))...
  11. pmc Effects of azithromycin in combination with vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms
    Elisabeth Presterl
    Department of Medicine I, Division of Infectious Diseases, Medical University of Vienna, Allgemeines Krankenhaus, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Antimicrob Agents Chemother 53:3205-10. 2009
    ..the effects of vancomycin (VAN), daptomycin (DAP), fosfomycin (FOS), tigecycline (TGC), and ceftriaxone (CRX), alone and in combination with azithromycin (AZI), on established biofilms of Staphylococcus epidermidis...
  12. pmc Informative value of Patient Reported Outcomes (PRO) in Health Technology Assessment (HTA)
    Christian Brettschneider
    University Medical Center Hamburg Eppendorf, Department of Medical Sociology and Health Economics, Hamburg, Germany
    GMS Health Technol Assess 7:Doc01. 2011
    ..The search for HTA-reports and methodological papers of HTA-agencies was performed in the CRD-Databases (CRD = Centre for Reviews and Dissemination) and by handsearching the websites of INAHTA member agencies (..
  13. ncbi The early effects of dietary restriction on the pathogenesis of chronic renal disease in Sprague-Dawley rats at 12 months
    L A Gumprecht
    Department of Veterinary Pathobiology, University of Illinois College of Veterinary Medicine, Urbana 61801
    Toxicol Pathol 21:528-37. 1993
    ..study evaluated the effects of different diets and dietary regimens on the pathogenesis of chronic renal disease (CRD) in Sprague-Dawley rats at 52 wk and correlated these data with survival at 106 wk...
  14. ncbi The primary structure and carbohydrate specificity of a beta-galactosyl-binding lectin from toad (Bufo arenarum Hensel) ovary reveal closer similarities to the mammalian galectin-1 than to the galectin from the clawed frog Xenopus laevis
    H Ahmed
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21202, USA
    J Biol Chem 271:33083-94. 1996
    ..exhibited the highest identity (48% for the whole molecule and 77% for the carbohydrate recognition domain (CRD)) with the bovine spleen galectin-1, but surprisingly less identity (38% for the whole molecule and 47% for the CRD)..
  15. ncbi The second glutamic acid in the C-terminal CRD affects the carbohydrate-binding properties of recombinant galectins of Haemonchus contortus
    Jing Wang
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, PR China
    Vet Parasitol 148:247-55. 2007
    ..The second E in the CRD, WGNEER, of Hco-GAL-m was mutated to glycine acid (G) and resulted in a recombinant galectin (MG mutate) with a CRD ..
  16. pmc Galectin multimerization and lattice formation are regulated by linker region structure
    Lesley A Earl
    Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Glycobiology 21:6-12. 2011
    ..Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical ..
  17. ncbi Expression of Mycobacterium leprae 18-kDa antigen in yeast in a GPI-anchored form
    A G Amorim
    Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, , Brasil
    Braz J Med Biol Res 27:623-6. 1994
    ..In addition, these cells react with an alpha-CRD antibody after GPI-PLC treatment. The non-transformed cells are negative...
  18. pmc Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa
    Sara J Bowne
    Human Genetics Center, School of Public Health, The University of Texas HSC, Houston, TX 77030, USA
    Hum Mol Genet 11:559-68. 2002
    ..A screen of retinal transcripts comparing retinas from normal mice to retinas from crx-/crx- knockout mice (with poorly differentiated photoreceptors) demonstrated a 6-fold reduction in one candidate, ..
  19. pmc Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency
    Gareth G Lavery
    Division of Medical Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 93:3827-32. 2008
    Cortisone reductase deficiency (CRD) is characterized by a failure to regenerate cortisol from cortisone via 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), resulting in increased cortisol clearance, activation of the ..
  20. ncbi Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina
    Adam D Rutherford
    Developmental Biology Unit, Institute of Child Health, University College London, London, United Kingdom
    Invest Ophthalmol Vis Sci 45:375-84. 2004
    ..The purpose of this study was to examine how neuronal development is affected by absence of the Chx10 transcription factor in the mouse retina...
  21. pmc Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine Research Center, Universite de Montreal, 3175, Ste Catherine Road, Montreal, Quebec, H3T 1C5, Canada
    Orphanet J Rare Dis 5:24. 2010
    ..Familial hypocholesterolemia, namely abetalipoproteinemia, hypobetalipoproteinemia and chylomicron retention disease (CRD), are rare genetic diseases that cause malnutrition, failure to thrive, growth failure and vitamin E deficiency, as ..
  22. ncbi Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels
    Eleonora Distrutti
    University of Perugia, Clinica di Gastroenterologia, Policlinico Monteluce, Via Enrico Dal Pozzo, 06122 Perugia, Italy
    J Pharmacol Exp Ther 316:325-35. 2006
    ..rats (healthy and postcolitic), and rectal nociception was assessed by measuring the behavioral response during CRD. Healthy rats were administered with sodium hydrogen sulfide (NaHS) (as a source of H(2)S), L-cysteine, or vehicle...
  23. pmc Genomic organization of zebrafish cone-rod homeobox gene and exclusion as a candidate gene for retinal degeneration in niezerka and mikre oko
    Deborah C Otteson
    Guerrieri Center for Genetic Engineering and Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mol Vis 11:986-95. 2005
    To determine the genomic organization of the zebrafish crx gene and to evaluate if mutations in crx are responsible for the retinal degeneration phenotype in the zebrafish (Danio rerio) mutants niezerka (nie(m743)) and mikre oko (mok(..
  24. doi PmLT, a C-type lectin specific to hepatopancreas is involved in the innate defense of the shrimp Penaeus monodon
    Tracy Hoi Tung Ma
    School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    J Invertebr Pathol 99:332-41. 2008
    ..Unlike the other two P. monodon lectin-like proteins described to date that have one CRD, PmLT has two CRDs...
  25. ncbi A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome
    Jose L San Millan
    Department of Endocrinology, Hospital Ramon y Cajal, Carretera de Colmenar Km 9 1, E 28034 Madrid, Spain
    J Clin Endocrinol Metab 90:4157-62. 2005
    ..83557insA mutations in 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 1 gene (HSD11B1) interact, resulting in cortisone reductase deficiency (CRD), a rare disorder characterized by a polycystic ovary syndrome (PCOS)-like phenotype.
  26. ncbi Equine trypanosomosis in the Central River Division of The Gambia: a study of veterinary gate-clinic consultation records
    S Dhollander
    International Trypanotolerance Centre, PMB 14 Banjul, The Gambia
    Prev Vet Med 75:152-62. 2006
    ..of this study was to provide epidemiological information of equine trypanosomosis in the Central River Division (CRD) of The Gambia...
  27. ncbi Colonic inflammation induces fos expression in the thoracolumbar spinal cord increasing activity in the spinoparabrachial pathway
    Richard J Traub
    Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Pain 95:93-102. 2002
    ..In the rat, repetitive noxious colorectal distention (CRD) induces >200 Fos labeled cells per section in the lumbosacral segments, but few in the thoracolumbar segments, ..
  28. ncbi [Work capacity in patients on hemodialysis]
    Lidija Orlic
    Klinika za internu medicinu Klinicki bolnicki centar Rijeka T Strizića 3 51000 Rijeka, Hrvatska
    Acta Med Croatica 58:67-71. 2004
    ..During the progression of chronic renal disease (CRD) to terminal renal failure (TRF) physical activity of the patients becomes poorer...
  29. ncbi Efficacy and tolerability of intravenous continuous erythropoietin receptor activator: a 19-week, phase II, multicenter, randomized, open-label, dose-finding study with a 12-month extension phase in patients with chronic renal disease
    Anatole Besarab
    Division of Nephrology and Hypertension, Department o f Medicine, Henry Ford Hospital, Detroit, Michigan, USA
    Clin Ther 29:626-39. 2007
    A continuous erythropoietin receptor activator (C.E.R.A.) is currently in development for the treatment of anemia in patients with chronic renal disease (CRD) receiving or not receiving dialysis treatment.
  30. ncbi Clinical findings in early onset cone-rod dystrophy in the Standard Wire-haired Dachshund
    Ernst O Ropstad
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway
    Vet Ophthalmol 10:69-75. 2007
    To describe the clinical findings and the age of onset of cone-rod dystrophy (crd) in the Standard Wire-haired Dachshund (SWHD) and to evaluate which clinical tests could be used to obtain a reliable diagnosis.
  31. ncbi Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor
    N P Mullin
    Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 272:5668-81. 1997
    ..has been used to identify residues that ligate Ca2+ and sugar to the fourth C-type carbohydrate-recognition domain (CRD) of the macrophage mannose receptor...
  32. ncbi CORD9 a new locus for arCRD: mapping to 8p11, estimation of frequency, evaluation of a candidate gene
    M Danciger
    Jules Stein Eye Institute, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 42:2458-65. 2001
    ....
  33. ncbi Evaluating the efficacy of serum haptoglobin concentration as an indicator of respiratory-tract disease in dairy calves
    C Svensson
    Department of Animal Environment and Health, Swedish University of Agricultural Sciences, P O Box 234, SE 532 23 Skara, Sweden
    Vet J 174:288-94. 2007
    ..once at 24-56 days of age to evaluate the potential of S-Hp as an indicator of clinical respiratory-tract disease (CRD)...
  34. pmc Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicent
    S Desplat-Jego
    Laboratoire d Immunologie, CHU de la Conception, 147, Bd Baille, Marseille 13005, France
    World J Gastroenterol 13:2312-8. 2007
    ..NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn's disease (CrD) and ulcerative colitis (UC)...
  35. doi Effect of dietary organic and inorganic micromineral source and level on sow body, liver, colostrum, mature milk, and progeny mineral compositions over six parities
    J C Peters
    The Ohio Agricultural Research and Development Center, The Ohio State University, Columbus 43210 1095, Ohio, USA
    J Anim Sci 88:626-37. 2010
    ..from the sows were analyzed as a 2 x 3 x 4 factorial arrangement of treatments in a completely randomized design (CRD) with 3 replicates per treatment...
  36. ncbi Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency
    Nicole Draper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Nat Genet 34:434-9. 2003
    In cortisone reductase deficiency (CRD), activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS; refs. 1,2)...
  37. ncbi [The role of norepinephrine in down-regulation of visceral sensitivity in rats deprived of rapid eye movement sleep]
    Tong Ling
    Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Nei Ke Za Zhi 47:133-6. 2008
    ..To investigate the role of norepinephrine in the down-regulated visceral sensitivity of rats deprived of rapid eye movement (REM) sleep...
  38. ncbi Simultaneous measurement of optical scattering and extinction on dispersed aerosol samples
    Kathy D Dial
    Department of Chemistry and Biochemistry, MS1061, Texas Tech University, Lubbock, Texas 79409, USA
    Anal Chem 82:7885-96. 2010
    ..Extinction is measured with the well-established cavity ring-down (CRD) technique, and the scattering coefficient is determined through collection of light scattered from the CRD beam...
  39. ncbi Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR
    F P Cremers
    Department of Human Genetics, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 7:355-62. 1998
    ..in a consanguineous family with individuals showing either retinitis pigmentosa (RP) or cone-rod dystrophy (CRD)...
  40. ncbi Molecular cloning of rat sperm galactosyl receptor, a C-type lectin with in vitro egg binding activity
    E Rivkin
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, New York, New York
    Mol Reprod Dev 56:401-11. 2000
    ..Binding is mediated by a Ca(2+)-dependent carbohydrate-recognition domain (CRD) identical to that of the minor variant of rat hepatic lectin receptor 2/3 (RHL-2/3)...
  41. ncbi New laboratory methods to study tooth surface coverage and interproximal plaque control by dentifrice products
    Tao Xu
    Colgate Palmolive Technology Center, Piscataway, NJ, USA
    J Clin Dent 15:123-7. 2004
    ..The application of the model should offer visual evaluation of dentifrice coverage of the tooth surface, and measure dental plaque control at posterior interdental spaces with a dentifrice...
  42. doi A novel C-type lectin from bay scallop Argopecten irradians (AiCTL-7) agglutinating fungi with mannose specificity
    Pengfei Kong
    Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    Fish Shellfish Immunol 30:836-44. 2011
    ..open reading frame which encoded a signal peptide of 15 residues and a conserved carbohydrate-recognition domain (CRD) of 174 residues with the EPD and WSD motifs instead of the invariant EPN and WND motifs for determining the ..
  43. ncbi Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands
    Peter J Coombs
    Glycobiology Institute, Department of Biochemistry, University of Oxford, UK
    J Biol Chem 280:22993-9. 2005
    ..A scavenger receptors for modified low density lipoproteins but contains a C-type carbohydrate-recognition domain (CRD)...
  44. pmc Regulation of photoreceptor gene expression by Crx-associated transcription factor network
    Anne K Hennig
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1192:114-33. 2008
    ..This regulation is mediated by a network of photoreceptor transcription factors centered on Crx, an Otx-like homeodomain transcription factor...
  45. doi Chylomicron retention disease: a long term study of two cohorts
    Noel Peretti
    Department of Nutrition, CHU Sainte Justine, Universite de Montreal, GI Nutrition Unit, 3175 Ste Catherine Road, Montreal, Que, Canada
    Mol Genet Metab 97:136-42. 2009
    ..secretion, mutations of the Sar1B gene coding for Sar1 GTPase are associated with chylomicron retention disease (CRD)...
  46. doi Protective role of mouse MBL-C on intestinal mucosa during Shigella flexneri invasion
    Da Ming Zuo
    Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Int Immunol 21:1125-34. 2009
    ..The carbohydrate recognition domain (CRD) genes of mouse MBL-C (mMBL-C) were cloned and expressed in Escherichia coli...
  47. pmc Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin
    Wei Chuan Chang
    Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Biochem Pharmacol 81:388-95. 2011
    MBL structurally contains a type II-like collagenous domain and a carbohydrate recognition domain (CRD)...
  48. ncbi Psychological stress and the severity of post-inflammatory visceral hyperalgesia
    Tobias Liebregts
    Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    Eur J Pain 11:216-22. 2007
    ..Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function...
  49. doi Overcoming macrocyclic lactone resistance in Haemonchus contortus with pulse dosing of levamisole
    Kerri L Tyrrell
    CSIRO, Livestock Industries, Queensland Bioscience Precinct, Queensland, Australia
    Vet Parasitol 168:278-83. 2010
    The in vivo effect of dosing levamisole as a pulse release within an ivermectin (IVM) controlled-release device (CRD) was simulated by periodic dosing of levamisole to Haemonchus contortus-infected sheep already treated with an IVM CRD...
  50. doi Molecular cloning of a C-type lectin with two CRD domains from the banana shrimp Fenneropenaeus merguiensis: early gene up-regulation after Vibrio harveyi infection
    Onnicha Rattanaporn
    Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkla, Thailand
    J Invertebr Pathol 106:196-204. 2011
    ..The first CRD comprises a QPD motif with specificity for binding galactose and a single Ca(2+) binding site, while the second CRD ..
  51. pmc FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo
    Raghuveer S Mali
    Eye Research Institute, Oakland University, Rochester, MI, USA
    BMC Mol Biol 9:87. 2008
    ..FIZ1 in the retina increases during photoreceptor terminal maturation, when two key transcription factors NRL and CRX (Cone-Rod Homeobox) become detectable on the promoters of photoreceptor-specific genes (i.e. Rhodopsin, Pde6b)...
  52. doi First molluscan TNFR homologue in Zhikong scallop: molecular characterization and expression analysis
    Ling Li
    The Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Rd, Qingdao 266071, China
    Fish Shellfish Immunol 27:625-32. 2009
    ..necrosis factor receptors (TNFRs) are a superfamily of proteins characterized by the unique cysteine-rich domain (CRD) and their important roles in diverse physiological and pathological events such as inflammation, apoptosis, ..
  53. ncbi Naturally-occurring chronic renal disease in Australian cats: a prospective study of 184 cases
    J D White
    Faculty of Veterinary Science, The University of Sydney, Australia
    Aust Vet J 84:188-94. 2006
    To describe cases of naturally occurring feline chronic renal disease (CRD) in a defined population of Sydney.
  54. pmc FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro
    Raghuveer S Mali
    Eye Research Institute, Oakland University, Rochester, MI 48309, USA
    Exp Eye Res 84:349-60. 2007
    ..Functional implications of FIZ1/NRL interaction, on NRL- and CRX-mediated activation of the Rhodopsin (Rho) and cGMP-phosphodiesterase beta-subunit gene (PDE6B) promoters, were ..
  55. pmc Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins
    Mary Requena
    Unité INSERM U743, Equipe Immunité et Biothérapie Muqueuse, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Immunology 123:508-18. 2008
    ..functional natural immunoglobulin A (IgA) and IgG antibodies directed against the carbohydrate recognition domain (CRD) domain of the dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) molecule, ..
  56. ncbi A three base pair deletion encoding the amino acid (lysine-270) in the alpha-cone transducin gene
    Ana Luisa Pina
    McGill Ocular Genetics Laboratory, Montreal Children s Hospital Research Institute, McGill University, Montreal, PQ, Canada
    Mol Vis 10:265-71. 2004
    ..In this study we tested the hypothesis that mutations in GNAT2 cause cone-rod degeneration (CRD).
  57. ncbi Conserved transcriptional activators of the Xenopus rhodopsin gene
    S Leigh Whitaker
    Departments of Biochemistry and Molecular Biology and Ophthalmology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 279:49010-8. 2004
    ..identify and characterize two transcriptional activators of the Xenopus rhodopsin gene: homologs of the mammalian Crx and Nrl transcription factors, XOtx5 and XL-Nrl (originally named XL-maf), respectively...
  58. ncbi Role of corticotropin-releasing factor pathways in stress-related alterations of colonic motor function and viscerosensibility in female rodents
    YVETTE TACHE
    Center for Neurovisceral Sciences and Women s Health, and CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Gend Med 2:146-54. 2005
    ..In rodents, colorectal distention (CRD) induces abdominal contractions, and this visceromotor response is used to assess visceral pain...
  59. pmc Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease
    Yong Qing Gao
    Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Vis 13:287-92. 2007
    ..other transcription factors such as SP1, neural retina leucine zipper protein (NRL), and cone-rod homeobox gene (CRX)...
  60. doi Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension
    K Saito-Nakaya
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Neurogastroenterol Motil 20:1147-56. 2008
    ..We tested the hypothesis that a combination of previous inflammation and repetitive colorectal distention (CRD) makes the colon hypersensitive and that treatment with a corticotropin-releasing hormone receptor 1 (CRH-R1) ..
  61. doi The GABA(B) receptor agonist, baclofen, and the positive allosteric modulator, CGP7930, inhibit visceral pain-related responses to colorectal distension in rats
    Mikael Brusberg
    AstraZeneca R and D, Molndal, Sweden
    Neuropharmacology 56:362-7. 2009
    ..Female Sprague-Dawley rats were subjected to repeated, noxious colorectal distension (CRD) (12 distensions at 80 mmHg, for 30 s with 5 min intervals)...
  62. doi The impact of a single 24 h working day on cognitive and psychomotor performance in staff anaesthesiologists
    Nenad Karanovic
    Department of Anesthesiology and Intensive Care, University Hospital Split, Croatia
    Eur J Anaesthesiol 26:825-32. 2009
    ..The aim of this study was to explore the impact of a single in-hospital 24 h shift on the cognitive and psychomotor performance of anaesthesiologists in a surgical emergency department...
  63. doi The effectiveness and active ingredients of mutual support groups for family caregivers of people with psychotic disorders: a literature review
    Wai Tong Chien
    The School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnics, Hung Hom, Kowloon, Hong Kong SAR, China
    Int J Nurs Stud 46:1604-23. 2009
    ..To explore the literature through a systematic search to assess the effectiveness of mutual support groups for family caregivers of people with schizophrenia and other psychotic disorders...
  64. doi Component-resolved diagnosis from latex allergy by microarray
    D G Ebo
    Department of Immunology Allergology Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Clin Exp Allergy 40:348-58. 2010
    ..A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy...
  65. ncbi Reanalysis of systematic reviews: the case of invasive strategies for acute coronary syndromes
    Pekka Kuukasjärvi
    Finnish Office for Health Technology Assessment Finohta, Helsinki
    Int J Technol Assess Health Care 22:484-96. 2006
    ....
  66. ncbi Specificity of lung surfactant protein SP-A for both the carbohydrate and the lipid moieties of certain neutral glycolipids
    R A Childs
    Glycoconjugates Section, Medical Research Council, Clinical Research Center, Harrow, Middlesex, United Kingdom
    J Biol Chem 267:9972-9. 1992
    ..A recombinant carbohydrate recognition domain (CRD) of human SP-A inhibits the binding of human SP-A to galactosyl ceramide and to galactose- and mannose-bovine serum ..
  67. pmc Identification of a photoreceptor cell-specific nuclear receptor
    M Kobayashi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
    Proc Natl Acad Sci U S A 96:4814-9. 1999
    ..cell lines, PNR expression was observed in Y79 retinoblastoma along with other photoreceptor marker genes such as CRX. Among vertebrate receptors, PNR shares structural kinship with an orphan receptor TLX, and despite distinct ..
  68. ncbi Localization of retina/pineal-expressed sequences: identification of novel candidate genes for inherited retinal disorders
    M M Sohocki
    School of Public Health, The University of Texas Health Science Center, Houston, Texas 77225 0334, USA
    Genomics 58:29-33. 1999
    ..Examples include mutations in arrestin, rhodopsin kinase, and the cone-rod homeobox gene, CRX. To identify additional candidate genes for inherited retinal disorders, novel retina/pineal-expressed EST clusters ..
  69. ncbi Visual phenotype in patients with Arg41Gln and ala196+1bp mutations in the CRX gene
    R T Tzekov
    Retina Foundation of the Southwest, Dallas, Texas, USA
    Ophthalmic Genet 21:89-99. 2000
    ..The Ala196+1bp mutation was associated with an early-onset, severe form of cone-rod dystrophy similar to that described in the original CORD2 family (Evans et al., Arch Ophthalmol 1995;113:195-201).
  70. pmc Endogenous glycosylphosphatidylinositol-specific phospholipase C releases renal dipeptidase from kidney proximal tubules in vitro
    S W Park
    College of Pharmacy, Chonnam National University, Kwangju 500 757, Korea
    Biochem J 353:339-44. 2001
    ..Immunoblot analyses using an antibody against the cross-reacting determinant (CRD) inositol 1,2-cyclic monophosphate, the epitope formed by phospholipase C (PLC) cleavage of the GPI anchor on a ..
  71. ncbi Cell cycle regulation by galectin-12, a new member of the galectin superfamily
    R Y Yang
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 276:20252-60. 2001
    ..and characterization of a new galectin, galectin-12, which contains two domains that are homologous to the galectin CRD. The N-terminal domain contains all of the sequence elements predicted to form the two beta-sheets found in other ..
  72. ncbi BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site
    Nathaniel C Gordon
    Department of Protein Engineering, Genentech, Inc, One DNA Way, South San Francisco, California 94080, USA
    Biochemistry 42:5977-83. 2003
    ..However, the extracellular domain (ECD) of BR3 consists of only a partial CRD, with cysteine spacing distinct from other modules described previously...
  73. pmc Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo
    Antony M Jose
    Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:2730-6. 2005
    ..All nine amino acid substitutions are in the second CRD, the third CRD, or the kinase domain...
  74. ncbi Association of TGF-beta1 polymorphisms with chronic renal disease
    Elisabeth Coll
    Nephrology Service, Hospital Clinic, Faculty of Biology, Faculty of Medicine, University of Barcelona, Spain
    J Nephrol 17:794-9. 2004
    ..This study aimed to evaluate the association of TGF-beta1 polymorphisms with chronic renal disease (CRD), and its progression to dialysis in a retrospective longitudinal study of an end-stage renal disease (ESRD) cohort.
  75. ncbi Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter
    Shoji Kawamura
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277 8652, Japan
    Comp Biochem Physiol B Biochem Mol Biol 141:391-9. 2005
    ..conserved OTX (GATTA) and OTX-like (TATTA) sequences that can be recognized by the mammalian cone-rod homeobox (CRX) protein. However, binding of zebrafish crx to the OTX sequence has remained elusive...
  76. ncbi Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Pain 130:56-65. 2007
    ..Adult male Wistar rats were equipped for recording of visceromotor response (VMR) to phasic colorectal distension (CRD; 10-60 mmHg). VMR to CRD was recorded 24 h after an acute session of water avoidance (WA) stress (post-WA)...
  77. ncbi Electronic structures and chemical bonding in diatomic ScX to ZnX (X = S, Se, Te)
    Z J Wu
    Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People s Republic of China
    J Comput Chem 28:703-14. 2007
    ..For neutral and cationic molecules, the covalent character increases from ScX to CrX and from FeX to CuX with an exception of decrease at MnX and ZnX, while for anionic molecules, the trend is not ..
  78. ncbi Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity
    Atsuhiro Kanda
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA
    Hum Mutat 28:589-98. 2007
    ..NRL interacts with CRX, NR2E3, and other transcription factors and synergistically regulates the activity of photoreceptor-specific genes...
  79. pmc The cis-regulatory logic of the mammalian photoreceptor transcriptional network
    Timothy H C Hsiau
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 2:e643. 2007
    ..and computational analysis of the network controlled by the mammalian photoreceptor transcription factors, Crx, Nrl, and Nr2e3...
  80. ncbi Visceral hyperalgesia induced by neonatal maternal separation is associated with nerve growth factor-mediated central neuronal plasticity in rat spinal cord
    E K Y Chung
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China
    Neuroscience 149:685-95. 2007
    ..The expression of NGF and TrkA was examined in NH and NMS rats with or without colorectal distention (CRD) as determined by Western blot analysis and immunohistochemistry...
  81. doi Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
    ..avoidance stress (WAS) or sham stress for 1 h/day, and the visceromotor response to phasic colorectal distension (CRD) was assessed before and after the stress period...
  82. ncbi A proposed approach for the selection of the proper surgical therapy to obtain an adequate margin of resection in locally advanced ultra-low rectal cancer after modern preoperative CRX management
    Ignacio Echenique
    Auxilio Mutuo Hospital, Rio Piedras, PR 00918
    Bol Asoc Med P R 101:53-5. 2009
    ..guidelines for clinicians regarding the use of close margins for sphincter saving surgery following chemoradiation (CRX)...
  83. ncbi Some physiological measurements on growth, pod yields and polyamines in leaves of chili plants (Capsicum annuum cv. Hua Reua) in relation to applied organic manures and chemical fertilisers
    J Rapatsa
    Department of Plant Sciences, Faculty of Agricultural Technology, Maha Sarakham Rajabhat University, Mahasarakham 48000, Thailand
    Pak J Biol Sci 13:263-70. 2010
    ..A Completely Randomized Design (CRD) with four replications was used. Six treatments were allocated into two experimental fields, i.e...
  84. doi Absent, unrecognized, and minimal myotonic discharges in myotonic dystrophy type 2
    Nathan P Young
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 41:758-62. 2010
    ..all muscles, and misinterpretation of MDs as slow fibrillation potentials (n = 1) and complex repetitive discharge (CRD) activity (n = 1)...
  85. doi Identification, molecular characterization and expression analysis of a mucosal C-type lectin in the eastern oyster, Crassostrea virginica
    Xing Jing
    School of Marine and Atmospheric Sciences, State University of New York, Stony Brook, NY 11794, USA
    Fish Shellfish Immunol 30:851-8. 2011
    ..CvML presents a signal peptide and a single carbohydrate recognition domain (CRD) which contains a YPD motif and two putative conserved sites, WID and DCM, for calcium binding...
  86. doi Cr3+ in layered perovskites: do the electron paramagnetic resonance parameters only depend on the impurity-ligand distances?
    J M García-Lastra
    Nano Bio Spectroscopy Group and European Theoretical Spectroscopy Facility ETSF, Departamento Fisica de Materiales UPV EHU, Apartado 1072, 20018 San Sebastian, Spain
    J Phys Condens Matter 22:155502. 2010
    ..In contrast, when the active electrons localized in the CrX(6)(3-) complex (X = F, Cl) are allowed to feel the anisotropic electric field coming from the rest of the lattice ..
  87. doi Effects of a short-term carbohydrate-restricted diet on strength and power performance
    Jason C Sawyer
    Physical Education and Human Performance Department, Central Connecticut State University, New Britain, Connecticut, USA
    J Strength Cond Res 27:2255-62. 2013
    ..of the study was to examine the effects of switching from a habitual diet to a carbohydrate-restricted diet (CRD) on strength and power performance in trained men (n = 16) and women (n = 15)...
  88. pmc The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans
    Laura L Moffat
    Molecular Neurobiology Program, Department of Pharmacology, Skirball Institute, NYU School of Medicine, New York, NY 10016, USA
    Development 141:617-28. 2014
    ..The Frizzled cysteine-rich domain (CRD) and invariant second intracellular loop lysine are crucial for PLR-1 downregulation...
  89. doi Diagnosis and classification of ulcerative colitis
    Karsten Conrad
    Institute of Immunology, Medical Faculty of the Technical University of Dresden, Germany Electronic address
    Autoimmun Rev 13:463-6. 2014
    ..In contrast to Crohn's disease (CrD), UC is restricted to the colon and the inflammation is limited to the mucosal layer...
  90. doi Extracellular modulators of Wnt signalling
    Tomas Malinauskas
    Cold Spring Harbor Laboratory, W M Keck Structural Biology Laboratory, Cold Spring Harbor, NY 11724, USA
    Curr Opin Struct Biol 29:77-84. 2014
    ..Structures include Wnt in complex with the cysteine-rich domain (CRD) of Frizzled, extracellular fragments of Wnt co-receptor LRP6, LRP6-binding antagonists Dickkopf and Sclerostin, ..
  91. doi Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice
    Kirsten C G Van Dycke
    Centre for Health Protection, National Institute for Public Health and the Environment RIVM, Bilthoven 3720 BA, The Netherlands Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam 3000 CA, The Netherlands
    Curr Biol 25:1932-7. 2015
    ..studies in shift workers and flight attendants have associated chronic circadian rhythm disturbance (CRD) with increased breast cancer risk, causal evidence for this association is lacking...
  92. doi In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord
    K E Farrell
    School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia Hunter Medical Research Institute HMRI, Rankin Park, NSW, 2287, Australia
    Neuroscience 316:13-25. 2016
    ..Noxious colorectal distension (CRD) was used to determine whether SDH neurons received inputs from mechanical stimulation/distension of the colon...
  93. pmc Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose
    Khuchtumur Bum-Erdene
    Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia
    Sci Rep 6:20289. 2016
    Galectin-4 is a tandem-repeat galectin with two distinct carbohydrate recognition domains (CRD)...
  94. doi Chylomicron retention disease: A rare cause of chronic diarrhea
    S Ben Ameur
    Hedi Chaker Hospital, Department of Pediatrics, 3029 Sfax, Tunisia Faculty of Medicine, Sfax, Tunisia Electronic address
    Arch Pediatr 23:735-7. 2016
    Chylomicron retention disease (CRD) is a rare autosomal recessive hereditary hypocholesterolemic disorder...
  95. ncbi A cysteine-rich form of Xenopus neuregulin induces the expression of acetylcholine receptors in cultured myotubes
    J F Yang
    Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong, China
    Mol Cell Neurosci 13:415-29. 1999
    ..at the N-terminus; it could be an immunoglobulin (Ig)-like domain named Ig-NRG-1 or an apolar cysteine-rich domain (CRD) named CRD-NRG-1...
  96. ncbi Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein
    K L Hartshorn
    Departments of Medicine and Pathology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Physiol Lung Cell Mol Physiol 278:L90-8. 2000
    ..domain of rat pulmonary surfactant protein D (rSP-D) fused to the neck region and carbohydrate recognition domain (CRD) of conglutinin (termed SP-D/Cong(neck+CRD)) have markedly greater ability to inhibit infectivity of IAV than wild-..
  97. ncbi Collectins and collectin receptors in innate immunity
    U L Holmskov
    Institute of Medical Biology, University of Southern Denmark, Denmark
    APMIS Suppl 100:1-59. 2000
    ..amino-acid residues, including an N-terminal region of 28 residues, a collagen region of 114 residues and a neck-CRD region of 159 residues...
  98. ncbi Update on the molecular genetics of retinitis pigmentosa
    Q Wang
    Center for Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ophthalmic Genet 22:133-54. 2001
    ..1-cen, RP1 on 8p11-21, RGR on 10q23, ROM1 on 11q13, NRL on 14q11.1-11.2, CRX on 19q13.3, and PRKCG on 19q13.4...
  99. ncbi Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae
    Sandra Lobo
    Department of Biochemistry, University of Iowa, Iowa City, IA 52240, USA
    J Biol Chem 277:41268-73. 2002
    ..localized to the membrane of the endoplasmic reticulum and contains a conserved DHHC cysteine-rich domain (DHHC-CRD). Erf2p co-purifies with Erf4p (26 kDa) when it is expressed in yeast or in Escherichia coli...
  100. ncbi The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking region
    Miguel A Trujillo
    Department of Medicine, Mayo Clinic Mayo Foundation Rochester, Minnesota 55905, USA
    Mol Endocrinol 20:2559-75. 2006
    ..that the silencer was a complex element comprising four discrete entities, including a core repressor domain (CRD), an antisilencer domain (ASE) that contains elements mediating the orientation-independent silencer activity, and ..
  101. doi Activation of extracellular signal-regulated protein kinase is associated with colorectal distension-induced spinal and supraspinal neuronal response and neonatal maternal separation-induced visceral hyperalgesia in rats
    X J Zhang
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    J Mol Neurosci 37:274-87. 2009
    ..The present study aims to investigate whether ERK associates with the colorectal distension (CRD)-evoked neuronal response and the upregulated central sensitivity to CRD in NMS rats...

Research Grants65

  1. David J Shapiro; Fiscal Year: 2014
    ..and other oncogenes, MDR1 (multidrug resistance protein 1) and NF-?B by targeting the mRNA binding protein IMP-1/CRD-BP/IGF2BP1...
  2. Alpha2-adrenoceptors modulate TRPV4 and reduce inflammation-induced visceral pain
    MARTIN R WATTS; Fiscal Year: 2013
    ..VH will be assessed in treated and control rats by measuring visceromotor reflexes (VMR) to colorectal distension (CRD) using electromyographic recording...
  3. Coordination of Gene Expression in Retinal Development
    KENNETH MITTON; Fiscal Year: 2009
    ..Several transcription factors (NRL. NR2E3. CRX) are shown to be activators of rhodopsin expression...
  4. KEVIN ROBERT VINCENT; Fiscal Year: 2014
    ..and physical function: eccentrically-focused exercise (ERX) and traditional concentrically-focused exercise (CRX)...
  5. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..Thus, we are proposing to test CRX-526, a potent TLR4 inhibitor, for efficacy to prevent and/or reduce cerebral IRI...
  6. RANDO L ALLIKMETS; Fiscal Year: 2014
    ..of retinal degeneration phenotypes, such as autosomal recessive Stargardt disease (STGD), cone-rod dystrophy (CRD) and retinitis pigmentosa (RP)...
  7. QUANTITATIVE ANALYSIS AND ENGINEERING OF THE PHOTORECEPTOR TRANSCRIPTION NETWORK
    Joseph C Corbo; Fiscal Year: 2012
    ..a comprehensive model of the photoreceptor transcriptional network controlled by the transcription factors (TFs), Crx and Nrl...
  8. RANDO L ALLIKMETS; Fiscal Year: 2015
    ..ABCA4 gene are responsible for a wide variety of disorders, such as Stargardt disease (STGD), cone-rod dystrophy (CRD), retinitis pigmentosa (RP)...
  9. Cell type-specific roles of Rb in retinal differentiation
    Michael A Dyer; Fiscal Year: 2012
    ..regulates rod photoreceptor differentiation through rE2Fs and histone modification to activate the Nrl, Nr2e3 and Crx promoters. This is the first example of such complex regulation of neurogenesis by a tumor suppressor...
  10. The effect of TLR4 inhibition on lung transplant ischemia-reperfusion injury
    PERRY ARTHUR GENOVA; Fiscal Year: 2010
    ..The purpose of the Phase I STTR is to determine if CRX-526, a TLR4 inhibitor that we showed prevents edema due to IRI, can ameliorate lung IRI...
  11. Mark A Lemmon; Fiscal Year: 2016
    ..Ryks contain a Wnt Inhibitory Factor-1 (WIF) domain, and Rors contain an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding CRDs in the Frizzled receptors...
  12. JOHN ANANDA VAN AALST; Fiscal Year: 2015
    ..and the candidate's interest in translational stem cell therapies, the possibility of using umbilical crd (UC) mesenchymal stem cells (MSCs) for novel therapeutics drew increased interest...
  13. PATHOGENESIS OF ACANTHAMOEBA KERATITIS
    Noorjahan Panjwani; Fiscal Year: 2013
    ..hypothesize that the presence of antibodies in tear fluid specifically against the carbohydrate recognition domain (CRD) of MBP should be protective...
  14. Tiffany M Schmidt; Fiscal Year: 2014
    ..that only 50% of ipRGCs arise from the Math5 lineage and that non- Math5 ipRGCs express the transcription factor Crx, a transcription factor critical for development of the classical photoreceptors...
  15. Angela Haczku; Fiscal Year: 2014
    ..By studying the effects of a recombinant mutant SP-D containing the carbohydrate recognition (CRD), but not the collagen domain, and blocking antibodies against the negative Signal-Regulatory Protein (SIRP) on ..
  16. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2013
    ..and ER[unreadable]) in the spinal cord differentially modulate the visceromotor response to colorectal distention (CRD)...
  17. Agonist & Antagonist Activity and Binding on the TMD of hT1R3
    Marianna Max; Fiscal Year: 2010
    ..least 4 binding regions of the sweet receptor: the venus fly trap module (VFTM) of hT1R2, the cysteine-rich domain (CRD) of hT1R3 and the transmembrane domain (TMD) of hT1R3...
  18. MULTIPLEX CIS-REGULATORY ANALYSIS IN MAMMALIAN CELLS
    Joseph C Corbo; Fiscal Year: 2012
    ..assay to test 1,000 Chip-seq "peaks" that are enriched for binding to the key photoreceptor transcription factor, Crx. In a single, multiplexed experiment we will test all 1,000 genomic sequences for their ability to drive ..
  19. Comparative Resistance Exercise Effects on Knee Osteoarthritis Pain, Functional I
    KEVIN ROBERT VINCENT; Fiscal Year: 2012
    ..leg function at a lower cardiovascular and metabolic cost compared to concentrically focused resistance exercise (CRX)...
  20. Vladimir S Spiegelman; Fiscal Year: 2016
    ..by applicant): The goal of studies proposed here is to understand the role of the role of RNA-binding protein, CRD-BP, in melanocyte biology...
  21. Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
    Leslie H Lundahl; Fiscal Year: 2010
    ..Drug choice procedures offer another valid approach for testing CRD medications...
  22. Shiming Chen; Fiscal Year: 2016
    ..This regulatory network is centered on the cone-rod homeobox protein CRX and incorporates both photoreceptor-specific transcription factors (TFs) and general chromatin modulators...
  23. TERESA BORRAS; Fiscal Year: 2016
    ..during a steroid on/off switch, routes of administration and determination of the clinical relevant dose (CRD)...
  24. EXPRESSION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    Lorna Role; Fiscal Year: 2009
    ..signal that regulates the expression and distribution of neuronal nAChRs -- a neuregulin 1 splice-isoform, called CRD-Nrg1...
  25. The sweet protein brazzein and its interaction with the human taste receptor
    Fariba M Assadi-Porter; Fiscal Year: 2012
    ..studies of the sweet receptor indicate that brazzein interacts with specific residues in the cysteine-rich domain (CRD) of the T1R3 subunit...
  26. Fluoxetine for MDD/Cannabis Disorder in Young People
    Jack Cornelius; Fiscal Year: 2009
    ..in the treatment of adolescents with comorbid major depressive disorder and a cannabis related disorder (MDD/CRD)...
  27. James Ashe; Fiscal Year: 2016
    ..expectation that it will be a realistic and practical treatment option for patients with limb amputation or spinal crd injury...
  28. ADHERENCE BLOCKING VACCINE FOR AMEBIASIS
    William Petri; Fiscal Year: 2003
    ..In Project 2, recombinant CRD containing peptides will be expressed in edible plants...
  29. MURINE CRD: A MODEL OF CHRONIC PULMONARY IMFLAMMATION
    Gail Cassell; Fiscal Year: 1991
    ....
  30. Metabolism of Endothelial Dysfunction in Renal Disease
    Leticia Castillo; Fiscal Year: 2006
    ..The aims are: (1) to assess NO bioavailability in CRD and ESRD patients and in healthy controls in relation to: (l...
  31. PULMONARY SURFACTANT DYNAMICS AND SURFACTANT PROTEIN A
    DENNIS VOELKER; Fiscal Year: 2000
    ..formation, 2) a collagen domain, 3) an alpha helical forming neck region, and 4) a carbohydrate recognition domain (CRD)...
  32. Genetic variability of E. histolytica in Turkey
    William Petri; Fiscal Year: 2004
    ..Genetic diversity will be determined by 1) nested PCR amplification and sequencing of the CRD region of the lectin gene, 2) nested PCR -SREHP gene and 3) DNA microarray analysis...
  33. Role of an RNA-Binding Protein in Mammary Carcinogenesis
    Jeffrey Ross; Fiscal Year: 2009
    ..We call it the c-myc Coding Region instability Determinant-binding Protein or CRD-BP. because it binds to an instability determinant in the c-myc mRNA coding region...
  34. Modeling Sweet Protein-Receptor Interactions
    Meng Cui; Fiscal Year: 2010
    ..The Venus Flytrap Module (VFTM) and Cysteine Rich Domain (CRD) can be modeled based on the crystal structures of metabotropic glutamate receptors (mGluRs)...
  35. The Role of the TM of T1R2 in Sweet Receptor Activation
    Marianna Max; Fiscal Year: 2009
    ..sweeteners, natural sugars and dipeptide sweeteners), the VFTM of hT1R3 (natural sugars), the cysteine-rich domain (CRD) of hT1R3 (brazzein) and the transmembrane domain (TMD) of hT1R3 (cyclamate and NHDC)...
  36. HIGH GLYCEMIC DIET AND RISK OF NIDDM AND CHD
    Simin Liu; Fiscal Year: 2002
    ..adapted from the application) This is a resubmission of DK02767 "High glycemic diet and risk of type 2 DM and CRD, " a K08 program for advanced training and research leading to a career as an independent clinical scientist in ..
  37. Bone Marrow-Derived Stem Cell Transplantation to Retina
    STEVEN MCLOON; Fiscal Year: 2005
    ..and taurine, and/or transfecting the cells with a gene for the photoreceptor cell specific transcription factor, Crx. Second, co-culture treated bone marrow-derived stem cells with embryonic retina or transplant the cells to the ..
  38. AIR POLLUTANTS AND CHRONIC RESPIRATORY DISEASE
    Gail Thomas; Fiscal Year: 1980
    The objective of this program is to establish chronic respiratory disease (CRD) in mice using a strain of Mycoplasma pulmonis and to determine the effects of exposure to ozone (O3) and nitrogen dioxide (NO2) on the disease...
  39. Novel phospholipases C in trypanosomatids
    Silvia Moreno; Fiscal Year: 2009
    ..in vitro, the shedding of Ssp-4 without its lipid anchor (as demonstrated by its cross-reactive determinant (CRD) reactivity), and the increase in cellular ceramide when maximal surface expression of TcPI-PLC takes place...
  40. MECHANISMS OF NEUROTROPHIN RECEPTOR CROSSTALK
    RICK DOBROWSKY; Fiscal Year: 2002
    ..There is evidence that these signaling events are initiated in caveolae and caveolae related domains (CRD), lipid-rich domains enriched in cholesterol, glycolipids and specific proteins, including the key protein ..
  41. Endovascular Embolectomy for Stroke - Experimental Study
    YVES GOBIN; Fiscal Year: 2002
    ..The specific aim of this project is to design and test various versions of the Clot Retriever Device (CRD), a helix shaped nitinol device made to ensnare and retrieve thrombo-emboli from cerebral arteries...
  42. Targeting the cysteine rich domain of protein kinase C
    Jong Yun; Fiscal Year: 2002
    ..One such domain is the cysteine rich domain (CRD), which modulates intermolecular lipid-protein interactions...
  43. Regulated c-myc Destabilization during Differentiation
    Gary Brewer; Fiscal Year: 2006
    ..Moreover, the last 249 nt of the coding region, known as the c-myc coding region determinant or CRD, can confer regulation upon a heterologous mRNA...
  44. Pain Modulation and Visceral Stimulation
    Peggy Mason; Fiscal Year: 2007
    ..The proposed experiments use colorectal distension (CRD) as a model visceral stimulus to explore these issues. There are 6 aims: ...
  45. Transcriptional Regulation of Rhodopsin Kinase Gene
    SHAHROKH KHANI; Fiscal Year: 2006
    ..expression appears unaffected by targeted disruption of the major known cone-rod homeodomain transcription factor, Crx. Investigation into the mechanisms that control the transcription of Rk is therefore likely to provide a view of ..
  46. Visual regeneration by cone photoreceptor replacement
    JOSEPH BRZEZINSKI; Fiscal Year: 2009
    ..Next, we will transplant cone enriched hES cells into adult Crx null mice, which have no functional photoreceptors...
  47. ENHANCING COLLECTIN MEDIATED HOST DEFENSE
    Kevan Hartshorn; Fiscal Year: 2001
    ..which incorporates the N-terminus and collagen domain of SP-D fused with the carbohydrate recognition domain (CRD) of conglutinin...
  48. ASIC3 Modulation of Visceral Pain and Hyperalgesia
    R Jones; Fiscal Year: 2006
    ..The proposed study utilizes behavioral testing with colorectal distension (CRD) in inbred and transgenic mice, molecular analysis of primary afferent neurons with real-time polymerase-chain ..
  49. STRUCTURE/FUNCTION OF SURFACTANT PROTEIN D
    Erika Crouch; Fiscal Year: 2006
    ..Although each monomer contains a single lectin domain (CRD), SP-D is assembled as oligomers of trimeric subunits cross-linked within their N-peptides...
  50. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..Patient safety will be monitored by an NIH Data Safety Monitoring Board (DSMB). The MILES trial is designed as a pivotal study to determine if sirolimus is effective in stabilizing or improving lung function in patients with LAM. ..
  51. PERMISSIVE RETINAL GENE EXPRESSION VIA HYPOMETHYLATION
    JEFFREY BOATRIGHT; Fiscal Year: 2001
    ..abstract_text> ..
  52. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    ..These studies will elucidate the role of SP-A in the innate immune defense of the lung, and may assist in the design of optimal antimicrobial strategies. ..
  53. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2002
    ..Efforts have been made to attract established investigators from related disciplines who can complement the expertise of the LAM investigators. ..
  54. The 2007 LAM Foundation Lymphangioleiomyomatosis International Research Conferenc
    Francis McCormack; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Lymphangioleiomyomatosis Research Conference 2006
    Francis McCormack; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2003
    ..abstract_text> ..
  57. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
    ..abstract_text> ..
  58. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..The results will provide important insights into the roles of the surfactant proteins in preventing oxidative lung disease and may be useful for the design of novel recombinant proteins and peptides of therapeutic value. ..
  59. 2005 LAM Foundation Lymphangioleiomyomatosis Research
    Francis McCormack; Fiscal Year: 2005
    ..abstract_text> ..
  60. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..Specific aim 2 will demonstrate that peripheral CRF2 activation blunts colorectal distention (CRD) and stress-induced visceral pain...
  61. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  62. Mechanisms of Esophageal Pain
    JYOTI SENGUPTA; Fiscal Year: 2008
    ..Pharmacological study will provide insight in drug development in management of esophageal pain. [unreadable] [unreadable] [unreadable]..
  63. Sex Differences in Opioid Analgesia
    Anne Murphy; Fiscal Year: 2006
    ..In summary, these studies will establish that the intrinsic and extrinsic circuitry of the PAG is sexually dimorphic and provide the neural substrate for sex based differences in opioid analgesia. ..
  64. GENE EXPRESSION IN ENTAMOEBA HISTOLYTICA
    William Petri; Fiscal Year: 2008
    ..Successful completion of these studies will provide insight into transcription regulation of virulence factors by the novel mechanism of direct calcium control of an EF-hand containing transcription factor. ..