CRP

Summary

Gene Symbol: CRP
Description: C-reactive protein
Alias: PTX1, C-reactive protein, C-reactive protein, pentraxin-related, pentraxin 1
Species: human

Top Publications

  1. ncbi Production of C-reactive protein in Escherichia coli-infected patients with liver dysfunction due to liver cirrhosis
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Diagn Microbiol Infect Dis 51:227-30. 2005
  2. ncbi A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 78:136-44. 2003
  3. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
  4. pmc Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
    Abbas Dehghan
    Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands
    Circulation 123:731-8. 2011
  5. pmc C-reactive protein activates complement in infarcted human myocardium
    Remco Nijmeijer
    Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 163:269-75. 2003
  6. doi Role of C-reactive protein in cerebrovascular disease: a critical review
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Expert Rev Cardiovasc Ther 9:1565-84. 2011
  7. doi C-reactive protein as a biomarker for urological cancers
    Kazutaka Saito
    Department of Urology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Urol 8:659-66. 2011
  8. ncbi Expression of C-reactive protein by renal cell carcinomas and unaffected surrounding renal tissue
    Wolfram J Jabs
    Department of Medicine I, Division of Nephrology, University of Luebeck School of Medicine, Germany
    Kidney Int 68:2103-10. 2005
  9. pmc Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia
    Alexander Kovacs
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:13768-73. 2007
  10. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. Community Assessment of Freeway Pollution and Health
    Doug Brugge; Fiscal Year: 2012
  3. Endothelial Function and Peripheral Vein Bypass Graft Remodeling
    CHRISTOPHER DEAN OWENS; Fiscal Year: 2012
  4. Andrew H Miller; Fiscal Year: 2014
  5. Andrew J Fuligni; Fiscal Year: 2015
  6. Air Pollution, Intima-media Thickness, and Lung Function in College Students
    Edward Avol; Fiscal Year: 2010
  7. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
  8. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
  9. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
  10. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013

Detail Information

Publications395 found, 100 shown here

  1. ncbi Production of C-reactive protein in Escherichia coli-infected patients with liver dysfunction due to liver cirrhosis
    Wan Beom Park
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    Diagn Microbiol Infect Dis 51:227-30. 2005
    To assess the effect of liver dysfunction on the production of C-reactive protein (CRP), CRP levels were evaluated in patients with Escherichia coli bacteremia with or without liver cirrhosis (LC)...
  2. ncbi A C-reactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians
    Johanna K Wolford
    Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA
    Mol Genet Metab 78:136-44. 2003
    ..Results from recent prospective studies indicate that increased levels of C-reactive protein (CRP), a marker of immune system activation, are predictive of diabetes, independent of adiposity...
  3. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    ..of nitric oxide (NO) in the development and clinical course of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an effect on NO production.
  4. pmc Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
    Abbas Dehghan
    Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands
    Circulation 123:731-8. 2011
    C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels.
  5. pmc C-reactive protein activates complement in infarcted human myocardium
    Remco Nijmeijer
    Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 163:269-75. 2003
    Circulating levels of C-reactive protein (CRP) constitute a cardiovascular risk marker...
  6. doi Role of C-reactive protein in cerebrovascular disease: a critical review
    Mario Di Napoli
    Neurological Service, San Camillo de Lellis General Hospital, Rieti, Italy
    Expert Rev Cardiovasc Ther 9:1565-84. 2011
    C-reactive protein (CRP) is a blood marker of inflammation and a hallmark of the acute-phase response...
  7. doi C-reactive protein as a biomarker for urological cancers
    Kazutaka Saito
    Department of Urology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Nat Rev Urol 8:659-66. 2011
    ..C-reactive protein (CRP) is an acute-phase reactant, the levels of which can be objectively measured using standardized reliable assays, ..
  8. ncbi Expression of C-reactive protein by renal cell carcinomas and unaffected surrounding renal tissue
    Wolfram J Jabs
    Department of Medicine I, Division of Nephrology, University of Luebeck School of Medicine, Germany
    Kidney Int 68:2103-10. 2005
    Elevation of plasma C-reactive protein (CRP) is common in patients with renal cell carcinoma (RCC). Renal tubular epithelial cells are capable of synthesizing CRP...
  9. pmc Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia
    Alexander Kovacs
    Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:13768-73. 2007
    Increased baseline values of the acute-phase reactant C-reactive protein (CRP) are significantly associated with future cardiovascular disease, and some in vitro studies have claimed that human CRP (hCRP) has proatherogenic effects...
  10. pmc Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study
    Myriam Fornage
    Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 39:1952-9. 2008
    ..vessel disease of the brain, we investigated the association between common variation in the C-reactive protein (CRP) and interleukin (IL)-6 genes, plasma CRP and IL6 levels, and presence of MRI-defined white matter lesions (WML) ..
  11. ncbi Is serum C-reactive protein concentration correlated with HbA1c and insulin resistance in Type 2 diabetic men with or without coronary heart disease?
    M Bahceci
    Department of Endocrinology and Metabolism, Dicle University School of Medicine, Diyarbakir, Turkey
    J Endocrinol Invest 28:145-50. 2005
    C-reactive protein (CRP) is an inflammatory marker that predicts coronary heart disease (CHD) risk. Diabetes mellitus (DM) counts as a CHD risk equivalent...
  12. pmc C-reactive protein exacerbates renal ischemia-reperfusion injury
    Melissa A Pegues
    Department of Medicine, University of Alabama, Birmingham, AL, USA
    Am J Physiol Renal Physiol 304:F1358-65. 2013
    ..Inflammation accompanies IRI and increases the blood level of C-reactive protein (CRP), a biomarker of worsened outcomes in AKI...
  13. ncbi C-reactive protein, carotid intima-media thickness, and incidence of ischemic stroke in the elderly: the Cardiovascular Health Study
    Jie J Cao
    Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Circulation 108:166-70. 2003
    Increased carotid artery intima-media thickness (IMT) and elevated C-reactive protein (CRP) are both associated with the occurrence of stroke...
  14. ncbi A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein
    Alexander Kovacs
    Department of Cardiology, Karolinska Hospital, S 17176 Stockholm, Sweden
    Atherosclerosis 178:193-8. 2005
    The plasma CRP concentration has consistently been shown to be associated with the risk of future coronary heart disease (CHD) and recent studies have suggested that CRP has a pathogenic role in CHD...
  15. ncbi The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis
    Masako Tabuchi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700 8558, Japan
    J Lipid Res 48:768-81. 2007
    C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease...
  16. pmc C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 3:e1395. 2008
    C-reactive protein (CRP), an acute phase reactant and marker of inflammation, has been shown to predict risk of incident cardiovascular events...
  17. pmc Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa
    Elisabeth Israelsson
    Department of Cardiology, Karolinska University Hospital Solna, 17176 Stockholm, Sweden
    Malar J 8:136. 2009
    C-reactive protein (CRP) is an acute phase protein that can activate various immune cells and bind to certain Fcgamma receptors...
  18. pmc Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients
    Praveen Ravishankaran
    Department of General Surgery, Coimbatore Medical College Hospital, Coimbatore, Tamil Nadu, India
    World J Surg Oncol 9:18. 2011
    Breast cancer is a disease that continues to plague females during their entire lifetime. IL-6 and CRP are found to be elevated in various inflammatory and malignant diseases and their levels are found to correlate with the extent of the ..
  19. ncbi C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction
    Ling Li
    Department of Biomedical Sciences, University of Montreal, Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Montreal, Quebec, Canada
    Circ Res 95:877-83. 2004
    C-reactive protein (CRP), a characteristic inflammatory marker, is a powerful predictor of cardiovascular events. Recent data suggest that CRP may also promote atherogenesis through inducing endothelial dysfunction...
  20. doi C-reactive protein and risk of venous thromboembolism in the general population
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Arterioscler Thromb Vasc Biol 30:1672-8. 2010
    To examine the robustness of the association between C-reactive protein (CRP) levels and increased risk of venous thromboembolism (VTE) and to examine whether genetically elevated CRP levels cause VTE.
  21. doi C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes
    Lavinia Forte
    Department of Cardio Thoracic and Respiratory Sciences, Second University of Naples, Italy
    Int J Cardiol 152:7-12. 2011
    C-reactive protein (CRP) plasma levels correlate with cardiovascular events...
  22. doi No effect of C-reactive protein on early atherosclerosis in LDLR-/- / human C-reactive protein transgenic mice
    Michael Torzewski
    Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University Mainz, Mainz, Germany
    Thromb Haemost 99:196-201. 2008
    The association between increased concentrations of C-reactive protein (CRP) and future cardiovascular events is well established...
  23. doi CRP and the risk of atherosclerotic events
    Paolo Calabro
    Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Monaldi Hospital, Via L Bianchi, 80131, Naples, Italy
    Semin Immunopathol 31:79-94. 2009
    ..These include high-sensitivity C-reactive protein (hs-CRP), a simple downstream marker of inflammation, recently emerged as a major cardiovascular risk factor...
  24. pmc Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach
    Paul Welsh
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Clin Endocrinol Metab 95:93-9. 2010
    ..Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven...
  25. ncbi C-reactive protein and glycemic control in adults with diabetes
    Dana E King
    Department of Family Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes Care 26:1535-9. 2003
    ..Studies have indicated that C-reactive protein (CRP) is an important risk factor for cardiovascular disease...
  26. ncbi Human C-reactive protein binds activating Fcgamma receptors and protects myeloma tumor cells from apoptosis
    Jing Yang
    Department of Lymphoma and Myeloma, Division of Cancer Medicine, and the Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 12:252-65. 2007
    Elevated levels of C-reactive protein (CRP) are present in many disease situations including malignancies and may contribute to the pathogenesis of cardiovascular disorders...
  27. doi C-reactive protein as a prognostic marker for men with androgen-independent prostate cancer: results from the ASCENT trial
    Tomasz M Beer
    Division of Hematology and Medical Oncology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Cancer 112:2377-83. 2008
    ..The authors sought to determine whether specific blood proteins associated with inflammation predict for outcomes in men with metastatic androgen-independent prostate cancer (AIPC) who are initiating docetaxel-based chemotherapy...
  28. doi Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma
    Ye Cao
    State Key Laboratory of Oncology, South China, Guangzhou, Guangdong 510060, People s Republic of China
    Tumour Biol 33:1039-44. 2012
    C-reactive protein (CRP) is an acute-phase reactant that is a promising biomarker in patients with cancer of many kinds...
  29. ncbi No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice
    A Trion
    Department of Cardiology, Leiden University Medical Center, The Netherlands
    Arterioscler Thromb Vasc Biol 25:1635-40. 2005
    C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis...
  30. pmc Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration
    Ivana K Kim
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Mol Vis 14:1487-95. 2008
    To examine if the gene encoding C-reactive protein (CRP), a biomarker of inflammation, confers risk for neovascular age-related macular degeneration (AMD) in the presence of other modifiers of inflammation, including body mass index (BMI)..
  31. doi The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis
    M Rizzo
    Department of Clinical Medicine and Emerging Diseases, University Hospital P Giaccone of the University of Palermo, Italy
    Intern Med J 39:539-45. 2009
    ..European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but few data are available on the role ..
  32. pmc Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein
    Indrani Halder
    Behavioral Physiology Laboratory, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 24:160-7. 2010
    ..many studies have found psychological depression associated with higher circulating levels of C-reactive protein (CRP), not all findings are consistent...
  33. pmc Binding of C-reactive protein to modified low-density-lipoprotein particles: identification of cholesterol as a novel ligand for C-reactive protein
    Sanna Taskinen
    Wihuri Research Institute, Kalliolinnantie 4, FIN 00140 Helsinki, Finland
    Biochem J 367:403-12. 2002
    C-reactive protein (CRP), an acute-phase reactant, is present in atherosclerotic human arterial intima in association with lipids...
  34. ncbi The biological functions of C-reactive protein
    Alexander J Szalai
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, THT 437B, Birmingham, AL 35294 0006, USA
    Vascul Pharmacol 39:105-7. 2002
    ..various investigations that firmly establishes an important host defense function for human C-reactive protein (CRP)...
  35. ncbi Leptin induces C-reactive protein expression in vascular endothelial cells
    Prachi Singh
    Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street, SW, Rochester, MN 55905, USA
    Arterioscler Thromb Vasc Biol 27:e302-7. 2007
    ..Higher leptin levels are associated with increased levels of C-reactive protein (CRP), which itself elicits proatherogenic effects in the vascular endothelium...
  36. ncbi Variants in the CRP gene as a measure of lifelong differences in average C-reactive protein levels: the Cardiovascular Risk in Young Finns Study, 1980-2001
    Mika Kivimaki
    Department of Epidemiology and Public Health, Faculty of Biomedical Sciences, University College London, London, United Kingdom
    Am J Epidemiol 166:760-4. 2007
    Genetic association studies have used variants in the C-reactive protein (CRP) gene to estimate causal effects of lifelong circulating CRP levels on disease endpoints...
  37. doi IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein
    John Rogus
    Interleukin Genetics Inc, 135 Beaver Street, Waltham, MA, 02452, USA
    Hum Genet 123:387-98. 2008
    ..These findings may apply to other inducible genes and could provide a logical framework for exploring disease risk related to genetic variability in pathogenic mediators...
  38. doi Continuously-infused human C-reactive protein is neither proatherosclerotic nor proinflammatory in apolipoprotein E-deficient mice
    Miguel A Ortiz
    Methodist Research Institute, Clarian Health, 1800 N Capitol Avenue, Suite E504A, Indianapolis, IN 46202, USA
    Exp Biol Med (Maywood) 234:624-31. 2009
    ..that these disparities are related to (a) the use, in some studies, of contaminated nCRP, or to (b) variation in CRP levels associated with either its episodic administration or the use of CRP-transgenic mice...
  39. pmc Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease
    Paul Elliott
    Faculty of Medicine, Imperial College London, London, United Kingdom
    JAMA 302:37-48. 2009
    Plasma levels of C-reactive protein (CRP) are independently associated with risk of coronary heart disease, but whether CRP is causally associated with coronary heart disease or merely a marker of underlying atherosclerosis is uncertain.
  40. pmc C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans
    Ayo P Doumatey
    Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 21:3063-72. 2012
    C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity...
  41. doi Pentameric CRP attenuates inflammatory effects of mmLDL by inhibiting mmLDL--monocyte interactions
    Steffen U Eisenhardt
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 8008, Australia
    Atherosclerosis 224:384-93. 2012
    Previous studies have reported that C-reactive protein (CRP) interacting with low-density lipoproteins (LDL) affects macrophage activation and LDL uptake...
  42. pmc The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection
    Toh B Gang
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614, USA
    J Biol Chem 287:43116-25. 2012
    Human C-reactive protein (CRP) protects mice from lethal Streptococcus pneumoniae infection when injected into mice within the range of 6 h before to 2 h after the administration of pneumococci...
  43. doi Not only immunoglobulins, C-reactive protein too
    Alok Agrawal
    Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA Electronic address
    Mol Immunol 56:561-2. 2013
    ..Thus, that the functions of a protein depend upon its alternate structural states, and therefore on the surrounding milieu, is a more general phenomenon for some ancient molecules of the immune system than previously thought. ..
  44. doi Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia
    T Mölkänen
    Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Eur J Clin Microbiol Infect Dis 29:1131-7. 2010
    C-reactive protein (CRP) is widely used in early detection of sepsis or organ dysfunction. Several single nucleotide polymorphisms (SNPs) in the CRP gene are shown to be associated with variability of basal CRP...
  45. doi Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population
    Shinji Makita
    Department of Internal Medicine II, Iwate Medical University, 19 1 Uchimaru, Morioka 0208505, Japan
    Atherosclerosis 204:234-8. 2009
    High C-reactive protein (CRP) levels have been reported to be associated with an increased risk of atherosclerotic cardiovascular events...
  46. doi Usefulness of C-reactive protein in predicting early and late recurrences after atrial fibrillation ablation
    Nicolas Lellouche
    Hôpital Henri Mondor Fédération de Cardiologie, Assistance Publique Hopitaux de Paris, Université de Médecine Paris XII, Creteil, France
    Europace 11:662-4. 2009
    ..High C-reactive protein level was associated with fewer early arrhythmia recurrences. No relationship was found between C-reactive protein level and late arrhythmia recurrences...
  47. doi Association between C-reactive protein and adiposity in women
    Murielle Bochud
    Department of Medicine, University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1005 Lausanne, Switzerland
    J Clin Endocrinol Metab 94:3969-77. 2009
    The link between C-reactive protein (CRP) and adiposity deserves to be further explored, considering the controversial diabetogenic role of CRP.
  48. ncbi Chronic CRP-exposure inhibits VEGF-induced endothelial cell migration
    Christopher Schneeweis
    Department of Medicine Cardiology, German Heart Institute Berlin, Germany
    J Atheroscler Thromb 17:203-12. 2010
    C-reactive protein (CRP) is a pluripotent mediator of inflammation and is present at sites of vascular injury and in atherosclerotic lesions...
  49. doi Diagnostic usefulness of serum interleukin 6 (IL-6) and C-reactive protein (CRP) in the differentiation between pancreatic cancer and chronic pancreatitis
    Barbara Mroczko
    Department of Biochemical Diagnostics, Medical University, Białystok, Poland
    J Clin Lab Anal 24:256-61. 2010
    Previous studies have shown elevated serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) in patients with pancreatic cancer (PC)...
  50. pmc Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3
    Tiziano Barbui
    Hematology Department, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
    Haematologica 96:315-8. 2011
    ....
  51. doi C-reactive protein level predicts prognosis in patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy
    Yue Can Zeng
    Department of Medical Oncology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang 110022, China
    Tumour Biol 33:891-5. 2012
    The aim of this study was to investigate the effect of C-reactive protein (CRP) level on the prognosis of patients with locoregionally advanced laryngeal carcinoma treated with chemoradiotherapy...
  52. ncbi C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:647-55. 2004
    Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic.
  53. ncbi High-sensitivity C-reactive protein is independently associated with early carotid artery progression in women but not in men: the INVADE Study
    Kerstin Sander
    Department of Neurology, Technical University of Munich, Mohlstrasse 28, 81675 Munchen, Germany
    Stroke 38:2881-6. 2007
    ..Therefore, we investigated the effect of hsCRP on early carotid atherosclerosis progression and major vascular risk factors in men and women...
  54. ncbi Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus
    Andreas Pfutzner
    Institute for Clinical Research and Development, IKFE GmbH, Parcusstrasse 8, 55116 Mainz, Germany
    Clin Chem Lab Med 44:556-60. 2006
    ..Type 2 diabetes mellitus is associated with increased cardiovascular risk. One laboratory marker for cardiovascular risk assessment is high-sensitivity C-reactive protein (hsCRP)...
  55. ncbi Serum adiponectin, C-reactive protein and TNF-alpha levels in obese Korean children
    Jung Yeon Shin
    Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
    J Pediatr Endocrinol Metab 21:23-9. 2008
    To determine whether there are differences of serum adiponectin, CRP and TNF-a levels between obese and non-obese children and to investigate the relationship between childhood obesity and inflammation.
  56. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  57. pmc C-reactive protein, inflammatory conditions, and cardiovascular disease risk
    Ravi Dhingra
    National Heart Lung and Blood Institute s NHBLI Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Am J Med 120:1054-62. 2007
    It is uncertain to what extent high C-reactive protein (CRP) concentrations reflect the presence of inflammatory conditions in the community.
  58. ncbi Predictive value of C-reactive protein for major postoperative complications following off-pump coronary artery bypass surgery: prospective and observational trial
    Dae Hee Kim
    Department of Anesthesiology and Pain Medicine, Ajou University College of Medicine, Suwon, South Korea
    Circ J 73:872-7. 2009
    To prospectively investigate the predictive value of the preoperative C-reactive protein (CRP) concentration for major postoperative complications following off-pump coronary artery bypass (OPCAB) surgery.
  59. ncbi Immunohistochemical expression of C-reactive protein in squamous cell carcinoma of the esophagus - significance as a tumor marker
    Tadahiro Nozoe
    Department of General Surgery, Fukuoka Dental College Hospital, 2 15 1, Tamura, Sawara Ward, 814 0193, Fukuoka, Japan
    Cancer Lett 192:89-95. 2003
    C-reactive protein (CRP) is a prototype acute phase protein which has been known to be synthesized in hepatocytes...
  60. ncbi Local generation of C-reactive protein in diseased coronary artery venous bypass grafts and normal vascular tissue
    Wolfram J Jabs
    Department of Medicine I, University of Lübeck School of Medicine, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Circulation 108:1428-31. 2003
    ..In atherosclerotic diseases, serum C-reactive protein (CRP) levels have become an important diagnostic and prognostic marker...
  61. ncbi CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, 4635 II Ave, Res 1 Bldg, Rm 3000, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 291:H1170-6. 2006
    Monocyte-endothelial cell adhesion is a key early event in atherogenesis. C-reactive protein (CRP), a cardiovascular risk marker, is known to stimulate ICAM and VCAM in human aortic endothelial cells (HAEC) and induces monocyte-..
  62. ncbi Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, USA
    Circulation 114:2458-65. 2006
    Increased serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. Previous studies have suggested that genetic variation within the CRP gene is associated with serum CRP.
  63. ncbi C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport
    C D'Alessandris
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetologia 50:840-9. 2007
    C-reactive protein (CRP) is associated with insulin resistance and predicts development of type 2 diabetes. However, it is unknown whether CRP directly affects insulin signalling action...
  64. ncbi C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study
    C Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, 33014 University of Tampere, Finland
    Atherosclerosis 196:841-8. 2008
    Although C-reactive protein (CRP) is known to predict cardiovascular events, its status as a causal risk factor is still controversial...
  65. doi Single nucleotide polymorphisms in inflammation-related genes and mortality in a community-based cohort in Washington County, Maryland
    Lisa Gallicchio
    Prevention and Research Center, Weinberg Center for Women s Health and Medicine, Mercy Medical Center, Baltimore, MD 21202, USA
    Am J Epidemiol 167:807-13. 2008
    ..IFNgamma), lymphotoxin-alpha (LTalpha), tumor necrosis factor-alpha (TNFalpha), C-reactive protein (CRP), peroxisome proliferator-activated receptor (PPAR), and the human endothelial nitric oxide synthase (eNOS)...
  66. ncbi Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis
    Robert Y L Zee
    Division of Preventive Medicine, The Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215 1204, USA
    Atherosclerosis 162:217-9. 2002
    While increased concentrations of C-reactive protein (CRP) are associated with increased vascular risk, little information is available describing genetic determinants of this effect...
  67. ncbi Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 106:1439-41. 2002
    C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis.
  68. ncbi Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease
    D J Brull
    Centre for Cardiovascular Genetics, BHF Laboratories at UCL, Royal Free and UCL Medical School, London, UK
    Arterioscler Thromb Vasc Biol 23:2063-9. 2003
    C-reactive protein (CRP) concentrations are predictive of cardiovascular disease, and levels are heritable, in part. We identified novel polymorphisms in the CRP gene and assessed their influence on CRP level.
  69. pmc C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels
    Thomas O Obisesan
    Department of Kinesiology, University of Maryland, College Park, MD 20742 2611, USA
    Arterioscler Thromb Vasc Biol 24:1874-9. 2004
    The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels.
  70. ncbi Cardiovascular disease in U.S. patients with metabolic syndrome, diabetes, and elevated C-reactive protein
    Shaista Malik
    Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, C240 Medical Sciences, University of California, Irvine, CA 92697, USA
    Diabetes Care 28:690-3. 2005
    C-reactive protein (CRP) independently predicts cardiovascular disease (CVD); whether it can stratify risk in those with metabolic syndrome and diabetes is not well documented...
  71. ncbi C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus
    Francesco D'Aiuto
    Department of Periodontology and Eastman Clinical Investigation Center, Eastman Dental Institute and Hospital, 256 Gray s Inn Road, University College London UCL, London WC1X 8LD, UK
    Atherosclerosis 179:413-7. 2005
    Elevations in C-reactive protein (CRP) concentration are associated with an increased risk of future coronary events in prospective studies and it has been suggested that CRP could be used to aid risk prediction...
  72. ncbi Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level
    A J Szalai
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Mol Med (Berl) 83:440-7. 2005
    To investigate whether functional polymorphisms exist in the C-reactive protein (CRP) gene, i.e...
  73. ncbi Association of common CRP gene variants with CRP levels and cardiovascular events
    D T Miller
    Division of Hematology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Ann Hum Genet 69:623-38. 2005
    C-reactive protein (CRP) is a well-documented marker of atherosclerotic cardiovascular disease risk...
  74. pmc An elevated C-reactive protein concentration, prior to surgery, predicts poor cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer
    A B C Crumley
    1University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 94:1568-71. 2006
    ....
  75. ncbi Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study
    Carmela Rita Balistreri
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita degli Studi di Palermo, Italy
    Ann N Y Acad Sci 1067:276-81. 2006
    ..in all the phases of atherosclerosis, and increased production of the acute-phase reactant, C-reactive protein (CRP), predicts future cardiovascular events...
  76. ncbi Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype
    Claes Ladenvall
    Institute of Neuroscience and Physiology, Department of Neuroscience and Rehabilitation, Sahlgrenska Academy at Goteborg University, Guldhedsgatan 19, S 413 45 Goteborg, Sweden
    Stroke 37:2018-23. 2006
    C-reactive protein (CRP) has evolved as an inflammatory risk marker of cardiovascular disease. Several single-nucleotide polymorphisms at the CRP locus have been found to be associated with CRP levels...
  77. ncbi Genetic variation, C-reactive protein levels, and incidence of diabetes
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:872-8. 2007
    C-reactive protein (CRP) has been shown to be associated with type 2 diabetes, but whether CRP has a causal role is not yet clear. We examined the association in the Rotterdam Study, a population-based prospective cohort study...
  78. ncbi Triggered C-reactive protein (CRP) concentrations and the CRP gene -717A>G polymorphism in acute stroke or transient ischemic attack
    E Ben-Assayag
    Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Eur J Neurol 14:315-20. 2007
    C-reactive protein (CRP) increases following an acute stroke/transient ischemic attack (TIA), but the increment level varies among patients...
  79. ncbi C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque
    Aoi Nabata
    Department of Internal Medicine, Omiya Medical Center, Jichi Medical University, Amanuma Cho 1 847, Saitama City 330 8503, Japan
    Atherosclerosis 196:129-35. 2008
    C-reactive protein (CRP) has been suggested to directly induce the inflammatory response leading to the progression of atherosclerosis...
  80. pmc Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation
    Devang N Patel
    Department of Veterans Affairs, South Texas Veterans Health Care System, San Antonio, TX 78229 4404, USA
    J Biol Chem 282:27229-38. 2007
    Elevated systemic levels of the acute phase C-reactive protein (CRP) are predictors of future cardiovascular events. There is evidence that CRP may also play a direct role in atherogenesis...
  81. ncbi DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study
    Melanie Kolz
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 29:1250-8. 2008
    ..This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response...
  82. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    Although elevated levels of C-reactive protein (CRP) independently predict increased risk of development of metabolic syndrome, diabetes, myocardial infarction, and stroke, comprehensive analysis of the influence of genetic variation on ..
  83. pmc Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein
    Alexander P Reiner
    University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
    Am J Hum Genet 82:1193-201. 2008
    ..common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration...
  84. doi C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study
    Tanja B Grammer
    Synlab Centre of Laboratory Diagnostics Heidelberg, PO Box 10 47 80, D 69037 Heidelberg, Germany
    Eur Heart J 30:170-82. 2009
    ..Circulating C-reactive protein is associated with future cardiovascular events. The causal role of C-reactive protein in the development of atherosclerosis remains controversial...
  85. pmc Epidemiology, heritability, and genetic linkage of C-reactive protein in African Americans (from the Jackson Heart Study)
    Ervin R Fox
    University of Mississippi School of Medicine, Jackson, Mississippi, USA
    Am J Cardiol 102:835-41. 2008
    C-reactive protein (CRP) has been studied largely in white non-Hispanic cohorts. There is limited information on CRP's range of values, heritability, and relation to cardiovascular disease risk factors in African Americans...
  86. doi Genetically elevated C-reactive protein and ischemic vascular disease
    Jeppe Zacho
    Department of Clinical Biochemistry, Herlev Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen
    N Engl J Med 359:1897-908. 2008
    Elevated levels of C-reactive protein (CRP) are associated with increased risks of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is a causal association.
  87. pmc Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 155:53-8. 2009
    Atherosclerosis is characterized by a prominent inflammatory component and C-reactive protein (CRP) has been implicated to modulate the complement activity in atherosclerotic arteries via complement factor H (CFH) binding...
  88. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    Elevated circulating levels of C-reactive protein (CRP), interleukin (IL)-6 and fibrinogen (FG) have been repeatedly associated with many adverse outcomes in patients with chronic obstructive pulmonary disease (COPD)...
  89. doi Association of C-reactive protein and metabolic syndrome in a rural Chinese population
    Jiangping Wen
    Department of Laboratory Medicine, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China
    Clin Biochem 42:976-83. 2009
    To explore the relationship between C-reactive protein (CRP) and metabolic syndrome (MetS) in a rural Chinese population.
  90. pmc C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery
    Tjorvi E Perry
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 10:38. 2009
    Elevated baseline C-reactive protein (CRP) levels are associated with increased risk for developing cardiovascular disease. Several CRP gene variants have been associated with altered baseline CRP levels in ambulatory populations...
  91. doi C-reactive protein 1059G>C genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    J Am Coll Surg 209:477-83. 2009
    Little is known about how C-reactive protein (CRP) genetic polymorphisms influence the rise in serum CRP levels seen after surgery...
  92. doi The influence of statin treatment on the inflammatory biomarkers YKL-40 and HsCRP in patients with stable coronary artery disease
    Naja Dam Mygind
    Cardiac Catheterization Laboratory 2014, Department of Medicine B, Faculty of Health Sciences, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Inflamm Res 60:281-7. 2011
    ..The aim was to investigate the influence of statin treatment and lipid status on serum YKL-40 and Hs-CRP in patients with stable CAD.
  93. ncbi The physiological structure of human C-reactive protein and its complex with phosphocholine
    D Thompson
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX UK
    Structure 7:169-77. 1999
    Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation...
  94. pmc C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids
    Mi Kyung Chang
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0682, USA
    Proc Natl Acad Sci U S A 99:13043-8. 2002
    C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms...
  95. ncbi C-reactive protein and incident cardiovascular events among men with diabetes
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 27:889-94. 2004
    Several large prospective studies have shown that baseline levels of C-reactive protein (CRP) are an independent predictor of cardiovascular events among apparently healthy individuals...
  96. ncbi C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, 14EN 215, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 109:2058-67. 2004
    ..An elevated level of C-reactive protein (CRP) has emerged as one of the most powerful predictors of cardiovascular disease...
  97. ncbi Relation of polymorphism within the C-reactive protein gene and plasma CRP levels
    H Jacqueline Suk
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02215, USA
    Atherosclerosis 178:139-45. 2005
    We sought to investigate whether genetic variability within the CRP gene affects CRP levels. C-reactive protein (CRP), an acute-phase reactant in inflammation, is an important predictor for cardiovascular disease...
  98. ncbi Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events
    A J Szalai
    The University of Alabama, Birmingham, AL 35294 3408, USA
    Rheumatology (Oxford) 44:864-8. 2005
    To determine if a polymorphic GTn repeat in the intron of the C-reactive protein (CRP) gene associates with occurrence of vascular arterial events in systemic lupus erythematosus (SLE).
  99. ncbi Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Arterioscler Thromb Vasc Biol 25:1359-63. 2005
    In addition to being a cardiovascular risk marker, recent studies support a role for CRP in atherothrombosis. Several investigators have reported that CRP binds to Fcgamma receptors on leukocytes...
  100. pmc Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, WA, USA
    Am J Hum Genet 77:64-77. 2005
    Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women...
  101. ncbi C-reactive protein levels in non-obese pregnant women with gestational diabetes
    Simin Rota
    Department of Biochemistry, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Tohoku J Exp Med 206:341-5. 2005
    ..We demonstrated that serum C-reactive protein level was related with gestational diabetes mellitus and weight gain during pregnancy in late second and early third trimesters...

Research Grants69

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Community Assessment of Freeway Pollution and Health
    Doug Brugge; Fiscal Year: 2012
    ..C-reactive protein (CRP), an inflammatory marker of risk for cardiac illness, has been shown to increase in response to changes in ..
  3. Endothelial Function and Peripheral Vein Bypass Graft Remodeling
    CHRISTOPHER DEAN OWENS; Fiscal Year: 2012
    ..have previously shown that these patients have a distinct inflammatory phenotype as assessed by C-reactive protein (CRP)...
  4. Andrew H Miller; Fiscal Year: 2014
    ..more of patients with major depression exhibit increased inflammation as reflected by a plasma c- reactive protein (CRP) concentration >3mg/L...
  5. Andrew J Fuligni; Fiscal Year: 2015
    ..waist/hip ratio will be assessed, and dried blood spots will be obtained for the assessment of c-reactive-protein (CRP), cholesterol, and high density lipoproteins (HDL)...
  6. Air Pollution, Intima-media Thickness, and Lung Function in College Students
    Edward Avol; Fiscal Year: 2010
    ..Given systemic inflammation affecting CIMT, LF and dyslipidemia, low LF, high C-reactive protein (CRP) and high lipids (LDL) these markers will be used to those most susceptible to atherogenic effects of air pollution...
  7. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    ..in inflammatory components interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-1), and C-reactive protein (CRP) may contribute to renal damage...
  8. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..on a 35% (high) protein diet and this diet was associated with reduced concentrations of inflammatory indicators CRP and IL6, compared with sickle cell transgenics on a 20% (normal) diet...
  9. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..are positively associated with serological markers of inflammation and endothelial dysfunction (C-reactive protein [CRP], interleukin-6 [IL-6], intercellular adhesion molecule-1 [ICAM-1], and tumor necrosis factor alpha [TNF-alpha]) in ..
  10. Cranial Stimulation for Chemotherapy Symptoms in Breast Cancer
    Deborah B McGuire; Fiscal Year: 2013
    ..tumor necrosis factor alpha [TNF-1], interleukin-6 [IL-6], interleukin-IL1-2 [IL1-2], and C-reactive protein [CRP]), symptoms and QOL;(2) examine whether the symptoms of depression, anxiety, fatigue, sleep disturbances and pain ..
  11. Debra E Lyon; Fiscal Year: 2014
    ..symptoms and anxiety;fatigue;sleep disturbances;pain), inflammatory activation [(levels of C- reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin 1 beta (IL-1B), and interleukin 6 (IL- 6)], and epigenetic ..
  12. LAUREN BERSH ALLOY; Fiscal Year: 2016
    ..to assess proinflammatory and regulatory cytokines (a multicytokine array of 7 cytokines) and C-reactive protein (CRP), in parallel with ongoing assessments of life stress and depression and anxiety symptoms every 6 months...
  13. Risk Factors for Incident Alzheimer's Disease in a Biracial Community
    Denis A Evans; Fiscal Year: 2010
    ..Second, we will examine the relations of three markers of inflammation, Interleukin-6 (IL-6), C-Reactive Protein (CRP), and Tumor Necrosis Factor-a (TNF-a) to these outcomes...
  14. Dietary Inflammatory Index and Risk of Cancer in Women
    FRED KINYUY TABUNG; Fiscal Year: 2013
    ..the association of the DII with three markers of systemic inflammation: high-sensitivity C- reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha receptor 2 (TNF[unreadable]- 2) at baseline...
  15. Jenny T Mao; Fiscal Year: 2015
    ..15(S)-hydroxy-eicosatetraenoic acid (15-HETE), interleukin (IL)-6, IL-10, IL-12 and C-reactive protein (CRP);5) cancer relevant, pathway specific gene expression profiles (GEP);and 6) epigenetic profiles assessed by micro(..
  16. Maria Mori Brooks; Fiscal Year: 2014
    ..During the five- year follow-up, plasminogen activator inhibitor-1 (PAI-1), C-reactive protein (CRP), fibrinogen, and D-dimer were lower in the insulin sensitization group compared with the insulin provision group, ..
  17. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    ..measured by levels of TNF-1, TGF-21, Lipopolysaccharide binding protein (LBP), and C-Reactive Protein (CRP), with the development of NAFLD, and the intestinal microbiome...
  18. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..of our laboratory is to characterize the structure and function of the acute phase protein, C-reactive protein (CRP) and to relate these findings to human autoimmune diseases...
  19. FROUGH SAADATMAND; Fiscal Year: 2016
    ..of immune system dysregulation includes heightened levels of antibodies to the Epstein Barr Virus (EBV) and C reactive protein (CRP)...
  20. EDWARD CARLOS SUAREZ; Fiscal Year: 2014
    ..predict pre- to post-treatment decreases in circulating levels of plasma interleukin (IL)-6 and C-reactive protein (CRP), as well as attenuated stress-induced changes in in vitro cellular adhesion molecules (CD11/CD18) expression, ..
  21. Role of Oxidative Stress and Inflammation in HIV Cardiovascular Risk
    Cecilia M Shikuma; Fiscal Year: 2012
    ..artery, on deposition of coronary artery calcium by electron beam tomography, and on changes in levels of hs-CRP. Within this clinical trial, we propose to assess the role of Th17 lymphocytes and their secretory compounds ..
  22. Fadi Hage; Fiscal Year: 2016
    ..C-reactive protein (CRP) is a widely accepted blood marker for risk of cardiovascular disease in women...
  23. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Maternal inflammation will be assessed using high-sensitivity C- reactive protein (CRP) measured at d26 weeks'gestation...
  24. Vitamin D Status in Relation to Incident Type 2 Diabetes and Cardiometabolic Risk
    Anastassios G Pittas; Fiscal Year: 2010
    ..ratio, Corrected Insulin Response), insulin resistance (HOMA-IR) and systemic inflammation (C-reactive protein [CRP])...
  25. Philip W Shaul; Fiscal Year: 2016
    ..abundant in endothelium, and that it mediates endothelial NO synthase (eNOS) antagonism by IgG, C-reactive protein (CRP) and serum amyloid P component (SAP), which is the CRP-equivalent in mice...
  26. Tyler T Wright; Fiscal Year: 2015
    ..Though CRP is primarily of hepatic origin, it is also produced by neurons during times of CNS inflammation...
  27. Biomarkers of Obesity, Prostate Tissue Inflammation, and BPH Progression
    Jay H Fowke; Fiscal Year: 2013
    ..prostaglandin E2 (PGE-M) and F2-isoprostane (F2iP-M) metabolites), and blood adiponectin and C-reactive protein (CRP) levels, that may mediate the effects of obesity on BPH progression...
  28. Scott B Going; Fiscal Year: 2016
    ..Fasting levels of insulin, glucose, and C-reactive protein (CRP) will be measured to assess how insulin resistance (HOMA-IR) and inflammation (hsCRP) are related to bone...
  29. FcgRIIB links CRP signals with ITGAM functions: a G x G x G model of SLE.
    Alexander J Szalai; Fiscal Year: 2010
    Studies show that small variations in the CRP, FCGR2B, and ITGAM genes are associated with systemic lupus erythematosus (SLE)...
  30. Dietary fructose and low-grade inflammation
    Mario Kratz; Fiscal Year: 2012
    ..Low-grade systemic inflammation, specifically elevated plasma concentrations of C-reactive protein (CRP), is a risk factor for cardiovascular disease (CVD)...
  31. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..versus twice daily) of ETM activities on inflammatory biomarkers: interleukin (IL)-6, IL-10 and C-reactive protein (CRP)? (1b) What are the differences between the type (low or moderate) of ETM activities on inflammatory biomarkers: IL-..
  32. Vitamin D and Clinical Outcomes in Chronic Hemodialysis Patients
    MICHEL BENJAMIN CHONCHOL; Fiscal Year: 2012
    ..1) To measure levels of 25(OH)D, 1,25(OH)2D, Interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hs- CRP) in predialysis serum samples collected at baseline and during annual follow-up from chronic HD patients randomized ..
  33. C-Reactive Protein Regulation of the Interferon Response in SLE
    Carolyn Mold; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Recent studies have identified a promoter polymorphism in C-reactive protein (CRP) as a susceptibility locus for systemic lupus erythematosus (SLE)...
  34. Longitudinal C-Reactive Protein Levels and Outcomes in Hemodialysis Patients
    JONATHAN WILLIAM BAZELEY; Fiscal Year: 2010
    ..among HD patients has led to increasing clinical use of inflammatory biomarkers such as C-reactive protein (CRP), in many countries outside of North America, without substantial evidence that this practice improves outcomes...
  35. Bradley E Dougherty; Fiscal Year: 2016
    ..and depression are related to increased levels of systemic inflammatory markers, including C-reactive protein (CRP), and other immune system dysfunction. Inflammation plays a key role in the pathology of AMD...
  36. Longitudinal Aging Biomarker Study in India (LASI-Biomarkers)
    Jinkook Lee; Fiscal Year: 2012
    ..to further develop laboratory capacity to conduct DBS-based bioassays in India;(b) to measure C-reactive protein (CRP, a marker of inflammation), glycosylated hemoglobin (HbA1c, a marker of glucose metabolism), hemoglobin (Hb, a ..
  37. Interactions of C-Reactive Protein with Highly Curved Lipid Membranes
    Scott M Reed; Fiscal Year: 2013
    ..By utilizing nanoparticles that mimic the lipid structure of LDL, the mechanism of how C-reactive protein (CRP) distinguishes damaged LDL from intact LDL will be elucidated...
  38. Inflammation and Atherosclerosis in Rheumatoid Arthritis
    IVY ANN KU; Fiscal Year: 2010
    ..In the general population, individuals with elevated inflammatory biomarkers (e.g. C- reactive protein, CRP) have increased CV events...
  39. Systemic Endothelial Consequences of Periodontal Disease
    Salomon Amar; Fiscal Year: 2010
    ..periodontal disease was also associated with higher plasma levels of the acute phase reactant C-reactive protein (CRP)...
  40. CROSS CULTURAL STUDY OF LUNG CANCER RISK AND INFLAMMATORY PATHWAY SNPS
    Qiuyin Cai; Fiscal Year: 2011
    ..We will also investigate the association of lung cancer risk with plasma C-reactive protein (CRP), a sensitive marker of systemic inflammation, and the urinary leukotriences E4...
  41. Inflammatory response to sleep apnea in obese subjects
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2010
    ..pressure (CPAP) therapy in these patients will more greatly reduce inflammation (measured by C-reactive protein or CRP) than weight loss alone, and that combining these two therapies will have additive effects on reducing inflammation...
  42. C-reactive protein supresses the immune system through Fc gamma receptors
    KRISTOPHER DAVID MARJON; Fiscal Year: 2010
    C-reactive protein (CRP) is an acute phase serum protein which is produced rapidly in response to inflammation...
  43. Exercise and Inflammation: Autonomic, Affective &Cellular Mechanisms
    Richard P Sloan; Fiscal Year: 2013
    ..Previous investigations generally have measured C-reactive protein (CRP) as the major endpoint...
  44. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..of inflammatory adipocytokines, including TNF-alpha and IL-6 which contribute to increase C-reactive protein (CRP), endothelial dysfunction and cardiovascular disease...
  45. Establish a Transgenic Model of Human C-Reactive Protein Over-expression in Rats
    Qingwei Wang; Fiscal Year: 2010
    ..A series of epidemiological studies have revealed a consistent association of circulating C-reactive protein (CRP) levels with risk of ischemic cardiovascular disease among apparently healthy individuals...
  46. Multi-plexed Cardiac Biomarker Detection Using Electrochemically Active Aptamers
    THOMAS W OWEN; Fiscal Year: 2010
    ..SAM and the ability of the modified electrodes to provide ultrasensitive detection of C-reactive protein (CRP)...
  47. Adi Cohen; Fiscal Year: 2015
    ..serum low-density-lipoprotein (LDL) cholesterol and cardiovascular risk markers such as C-reactive protein (CRP), interleukin-6 (IL-6) and homocysteine...
  48. Lisa Fredman; Fiscal Year: 2014
    ..stored serum from SOF visits 8 and 9 for assays on 3 inflammatory markers (Interleukin-6, IL-6;C-reactive protein, CRP;and Tumor Necrosis Factor- alpha, TNF-1)...
  49. Sue M Penckofer; Fiscal Year: 2016
    ..Evidence indicates that in depression, pro-inflammatory biomarkers, notably cytokines and C-reactive protein (CRP), are elevated...
  50. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..serum vitamin D and biomarkers of cancer risk tested in the parent RCT (insulin resistance and C-reactive protein [CRP]);and 2) examine associations between change in body composition and change in other outcomes such as strength, ..
  51. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ..growth factor (IGF-I);adipocyte markers: leptin, adiponectin;and inflammatory markers: C-reactive protein (CRP), lnterleukin-6 (IL-6), and tumor necrosis factor (TNF);(2) To conduct cross-sectional and longitudinal co-twin ..
  52. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    The circulating level of C-reactive protein (CRP) is a strong predictor of endothelial dysfunction and hypertension in humans...
  53. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..We showed that C-Reactive Protein (CRP) was associated with heart failure (HF) and death while lipoprotein- associated phospholipase A2 (Lp-PLA2), was ..
  54. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2013
    ..mortality involve the potential role of estrogens, insulin, insulin-like growth factors (IGFs) C-reactive protein (CRP), leptin, CA-125, prolactin, osteopontin, and macrophage inhibitory factor...
  55. Nicole Schupf; Fiscal Year: 2015
    ..cohort, including lipids, amyloid peptides, sex hormones, homocysteine, insulin and C-reactive protein (CRP), and MRI...
  56. Retinal degeneration caused by alterations in protein tyrosine O-sulfation
    Muayyad R Al-Ubaidi; Fiscal Year: 2013
    ..tyrosine(s) will be mutated to phenylalanines and in vitro analyses of 1) ability of unsulfated CFH to bind CRP (C-reactive protein), 2) its ability to self-dimerize and 3) its interactions with polyanions...
  57. Childhood Precursors for Adulthood Metabolic Syndrome
    Shumei S Sun; Fiscal Year: 2010
    ..fat-free mass, lipid profiles, insulin resistance, blood pressure, leptin, adiponectin and C-reactive protein (CRP) in relation to the presence or absence of the metabolic syndrome in adulthood;and, (3) to relate adulthood changes ..
  58. Apoptotic Cells As Immunogens In SLE
    Keith B Elkon; Fiscal Year: 2010
    ..We will also determine how C-reactive protein (CRP) exerts its immunosuppressive effect on ARC and whether the suppressive effects exerted by these pathways can ..
  59. The Effects of Antiepileptic Drugs on Serologic Indices of Vascular Risk
    Scott Mintzer; Fiscal Year: 2012
    ..in wide-ranging and detrimental metabolic effects such as elevations in serum cholesterol and C-reactive protein (CRP)...
  60. Alice S Chen-Plotkin; Fiscal Year: 2016
    ..tyrosine kinase (AXL), matrix metalloproteinase-2 (MMP-2), interleukin-7 (IL-7), EGF, and C-reactive protein (CRP) correlate with rate of PD motor decline in additional cohorts of UPenn patients, using alternative platforms for ..
  61. Inflammatory markers as predictors of active labor onset among nulliparous women
    Jeremy L Neal; Fiscal Year: 2011
    ..e., white blood cell (WBC) count, serum pro-inflammatory cytokines (IL-12, IL-6, IL-8, TNF-1), C-reactive protein (CRP);and body temperature] over time and the amount of cervical dilation during the first 4 hrs post-admission...
  62. Modified C-reactive protein for novel treatment of lupus nephritis.
    MEGHAN NORVELL; Fiscal Year: 2010
    ..new therapeutic treatment that this application will develop is based on the demonstration that C-reactive protein (CRP), a classical acute phase serum protein, reverses lupus nephritis with a onetime injection in multiple mouse models...
  63. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..Notably, low levels of high-density lipoprotein cholesterol (HDL-C), elevated inflammation (C-reactive protein (CRP) and interleukins (IL-1A)), deranged glucose homeostasis, hypertension and endothelia dysfunction are precursors of ..
  64. INFECTION AND CARDIOVASCULAR DISEASE
    Michael Davidson; Fiscal Year: 2001
    ..PBMCs can reflect an unsuccessful host cellular immune response to CMV associated with elevated C-reactive protein (CRP)...
  65. Exploring the effect of a low-fat diet and/or exercise on change in inflammatory
    Deborah Young; Fiscal Year: 2009
    ..that vigorous physical activity is associated with lower inflammatory markers, particularly C-reactive protein (CRP)...
  66. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
    ..process characterized by elevations in pro-inflammatory cytokines and the acute phase reactant C-reactive protein (CRP)...
  67. C-Reactive Protein in Human Mucosal Immunity
    Jane Gould; Fiscal Year: 2005
    C-reactive protein(CRP), an acute phase reactant, is a normal constituent of human sera...
  68. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..have to delineate the mechanisms that mediate induction of the major human acute phase protein C-reactive protein (CRP) in hepatocytes...
  69. INTERACTIONS OF CRP WITH HUMAN MONOCYTES AND NEUTROPHILS
    Janice Zeller; Fiscal Year: 1990
    ..Our laboratory has reported that C-reactive protein (CRP), an acute phase reactant, binds to human monocytes and neutrophils and enhances their respiratory burst response ..