CRHR2

Summary

Gene Symbol: CRHR2
Description: corticotropin releasing hormone receptor 2
Alias: CRF-RB, CRF2, CRFR2, HM-CRF, corticotropin-releasing factor receptor 2, CRF2 receptor, beta isoform, CRH receptor 2 variant B, CRH-R2
Species: human

Top Publications

  1. ncbi Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment
    Delia M Vazquez
    Department of Pediatrics, Endocrine Division, University of Michigan, 1150 West Medical Center Drive, 8346 Medical Science Research Building III, Ann Arbor, MI 48109 0646, USA
    Neuropsychopharmacology 28:898-909. 2003
  2. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
  3. ncbi Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    Neuroendocrinology 84:49-57. 2006
  4. ncbi Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin
    Hong Tu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 21:700-11. 2007
  5. ncbi Involvement of corticotropin-releasing factor receptor 2 beta in differentiation of dopaminergic MN9D cells
    Tae Eun Jin
    Department of Physiology, Sungkyunkwan University, School of Medicine and Center For Molecular Medicine, Samsung Biomedical Research Institute, Suwon 440 746, Korea
    Mol Cells 26:243-9. 2008
  6. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
  7. doi Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:2866-76. 2008
  8. ncbi Cloning and characterization of human urocortin
    C J Donaldson
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla 92037, USA
    Endocrinology 137:2167-70. 1996
  9. ncbi Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis
    Ekaterini Chatzaki
    Laboratory of Pharmacology, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece
    J Cell Physiol 209:905-11. 2006
  10. doi Urocortin's inhibition of tumor growth and angiogenesis in hepatocellular carcinoma via corticotrophin-releasing factor receptor 2
    Juejin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Cancer Invest 26:359-68. 2008

Research Grants

  1. Marc R Montminy; Fiscal Year: 2014
  2. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
  3. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
  4. Central neural function of Urocortin 3 in regulating energy balance
    Chien Li; Fiscal Year: 2013
  5. Tracy L Bale; Fiscal Year: 2015
  6. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
  7. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
  8. CRF Modulation of NMDA Currents and Behavior in the VTA
    Matthijs Verhage; Fiscal Year: 2013
  9. Bimolecular interactions of CRF ligands and receptors
    Abdul Abou Samra; Fiscal Year: 2006
  10. Urocortin, Dorsal Raphe & Ethanol-induced Hypothermia
    VICTORIA TUREK; Fiscal Year: 2005

Detail Information

Publications192 found, 100 shown here

  1. ncbi Impact of maternal deprivation on brain corticotropin-releasing hormone circuits: prevention of CRH receptor-2 mRNA changes by desipramine treatment
    Delia M Vazquez
    Department of Pediatrics, Endocrine Division, University of Michigan, 1150 West Medical Center Drive, 8346 Medical Science Research Building III, Ann Arbor, MI 48109 0646, USA
    Neuropsychopharmacology 28:898-909. 2003
    ..In amygdala, CRHr1 and r2 mRNAs were decreased. CRHr2 mRNA was also decreased in the ventromedial nucleus of the hypothalamus, whereas an increase was detected in the ..
  2. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
    ..This widespread expression of the CRH system in gestational tissue suggests a paracrine role for CRH in the birth process (e.g. effects on macrophages and endothelial cells)...
  3. ncbi Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells
    Ioannis Charalampopoulos
    Department of Pharmacology, School of Medicine, University of Crete, Heraklion, Greece
    Neuroendocrinology 84:49-57. 2006
    ..Our findings are as follows: (1) In highly purified KCs the transcripts of UCN, of its receptors CRHR1, CRHR2 and that of the pseudoreceptor CRH-binding protein (CRHBP) were present while that of CRH was not detectable...
  4. ncbi Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin
    Hong Tu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 21:700-11. 2007
    ..CRHR1-mediated urocortin endocytosis was blocked by astressin (antagonist for both CRHRs), whereas CRHR2-mediated urocortin endocytosis was also blocked by antisauvagine 30 (selective CRHR2beta antagonist)...
  5. ncbi Involvement of corticotropin-releasing factor receptor 2 beta in differentiation of dopaminergic MN9D cells
    Tae Eun Jin
    Department of Physiology, Sungkyunkwan University, School of Medicine and Center For Molecular Medicine, Samsung Biomedical Research Institute, Suwon 440 746, Korea
    Mol Cells 26:243-9. 2008
    ..To validate this statement, we made a CRF receptor 2beta-overexpressing MN9D/CRFR2 beta stable cell line...
  6. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
    ..We found that both CRHR1 and CRHR2 were localized in cultured chorion trophoblast cells, with CRH-R1alpha, R1beta, R1c, R1e, and R1f and CRHR2beta ..
  7. doi Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:2866-76. 2008
    ....
  8. ncbi Cloning and characterization of human urocortin
    C J Donaldson
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla 92037, USA
    Endocrinology 137:2167-70. 1996
    ..The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33)...
  9. ncbi Corticotropin-releasing factor (CRF) receptor type 2 in the human stomach: protective biological role by inhibition of apoptosis
    Ekaterini Chatzaki
    Laboratory of Pharmacology, Democritus University of Thrace, Dragana, Alexandroupolis 68100, Greece
    J Cell Physiol 209:905-11. 2006
    ..Paracrine effects exerted by locally expressed endogenous ligands, such as Ucn I, support a significant role of the peripheral CRF system in gastric physiology. J. Cell. Physiol. 209: 905-911, 2006. (c) 2006 Wiley-Liss, Inc...
  10. doi Urocortin's inhibition of tumor growth and angiogenesis in hepatocellular carcinoma via corticotrophin-releasing factor receptor 2
    Juejin Wang
    Department of Pharmacology, Nanjing Medical University, Nanjing, China
    Cancer Invest 26:359-68. 2008
    Urocortin (UCN) functions via corticotrophin-releasing factor receptors (CRFRs), CRFR1 & 2. CRFR2 is reported to be a tonic suppressor of vascularization, implying its role in tumor angiogenesis...
  11. doi The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti-angiogenic signaling pathways
    Hossein Tezval
    Department of Urology and Urological Oncology, Hannover Medical School, Germany
    Prostate 69:443-8. 2009
    ..Ucn binds and activates corticotropin releasing factor (CRF) receptor 1 (CRFR1) and 2 (CRFR2)...
  12. pmc Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha
    Alan C Moss
    Gastrointestinal Neuropeptide Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Gut 56:1210-7. 2007
    ..II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin-releasing hormone receptor 2 (CRHR2) in peripheral tissues...
  13. pmc Corticotropin-releasing hormone receptor expression and functional signaling in murine gonadotrope-like cells
    Audrey F Seasholtz
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    J Endocrinol 200:223-32. 2009
    ..PCR (RT-PCR) studies demonstrated that alpha T3-1 cells express mRNA for the two CRH receptor subtypes, CRHR1 and CRHR2, with CRHR2alpha as the predominant CRHR2 isoform...
  14. ncbi Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I
    Ward A Pedersen
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci 22:404-12. 2002
    ..G-protein-coupled receptors have been identified that bind CRH and/or urocortin I and II, designated CRHR1 and CRHR2, both of which are present in hippocampal regions of mammalian brain...
  15. ncbi Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    Type 2 corticotropin-releasing factor (CRF) receptors (CRFR2) within the ventromedial hypothalamus (VMH), a key glucose-sensing region, play a major role in regulating the hormonal counterregulatory responses (CRRs) to acute hypoglycemia...
  16. ncbi Mouse corticotropin-releasing factor receptor type 2alpha gene: isolation, distribution, pharmacological characterization and regulation by stress and glucocorticoids
    Alon Chen
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Mol Endocrinol 19:441-58. 2005
    ..factor (CRF) family of peptides are mediated through activation of two receptors, CRF receptor (CRFR) 1 and CRFR2. Based on the homology between known mammalian CRFR genes, we have isolated a cDNA encoding the mouse CRFR2alpha (..
  17. ncbi Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart
    Bhawanjit K Brar
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 145:24-35; discussion 21-3. 2004
    ..001). The CRFR2 selective antagonist astressin2-B and an ERK1/2-p42, 44 inhibitor abolish the cardioprotective actions of Ucn-II ..
  18. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described...
  19. doi Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway
    Jin Tao
    Department of Neurobiology, Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, Suzhou, PR China
    Cell Signal 21:1436-43. 2009
    ..investigated the expression profile of CRF receptors in rat cerebellum and identified a novel functional role of CRFR2 in modulating Purkinje neuron P-type Ca(2+) currents (P-currents)...
  20. doi Differential stress-induced alterations of colonic corticotropin-releasing factor receptors in the Wistar Kyoto rat
    D O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Neurogastroenterol Motil 22:301-11. 2010
    ..KEY RESULTS No intra-strain differences were observed in the numbers of colonic CRFR1 and CRFR2 positive cells...
  21. pmc A soluble mouse brain splice variant of type 2alpha corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity
    Alon M Chen
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2620-5. 2005
    ..factor (CRF) family signal through the activation of two receptors, CRF receptor type 1 (CRFR1) and type 2 (CRFR2), both of which exist as multiple splice variants...
  22. pmc Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone
    Mohammad Tezval
    Department of Trauma, Plastic and Reconstructive Surgery, Goettingen University Hospital, University Medicine Goetingen, Robert Koch Str 40, 37075 Goettingen, Germany
    J Mol Histol 40:331-41. 2009
    ..of UCN are mediated via stimulation of CRF-receptors 1 and 2 (CRFR1 and 2, CRFR's) with a high affinity for CRFR2. It has been shown that the CRF-related peptides and CRFR's are involved in the regulation of stress-related ..
  23. ncbi Corticotropin-releasing hormone (CRH) depresses n-methyl-D-aspartate receptor-mediated current in cultured rat hippocampal neurons via CRH receptor type 1
    Hui Sheng
    Department of Physiology, Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:1389-98. 2008
    ..This effect was reversed by the CRH receptor type 1 (CRHR1) antagonist antalarmin but not by the CRHR2 antagonist astressin-2B, suggesting that CRHR1 mediated the inhibitory effect of CRH...
  24. pmc Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
    Damian Refojo
    Departamento Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Laboratorio de Fisiologia y Biologia Molecular, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
    Proc Natl Acad Sci U S A 102:6183-8. 2005
    ..To dissect the involvement of CRH receptor 1 (CRHR1) and CRHR2, we used conditional knockout mice in which Crhr1 is inactivated in the anterior forebrain and limbic structures...
  25. pmc Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor
    Kuntal Pal
    Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 285:40351-61. 2010
    ..and cardiovascular function by activating either of two related class B G protein-coupled receptors, CRFR1 and CRFR2. CRF and Ucn1 activate both receptors, whereas Ucn2 and Ucn3 are CRFR2-selective...
  26. pmc Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis
    Jen Chang
    Department of Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Peptides 28:1453-60. 2007
    ..a large population of immune cells that infiltrated the lamina propria and submucosa of the distal colon, whereas CRFR2-IR was detected in only a small fraction of infiltrated immune cells...
  27. pmc A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss
    Christine E Graham
    Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA
    Neurobiol Dis 38:246-58. 2010
    ..We demonstrate that mice lacking the CRF receptor CRFR2 exhibit a significantly lower auditory threshold than wild type mice, but this gain of function comes at the price ..
  28. doi Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring
    J M Fan
    Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    Neuroscience 159:1363-73. 2009
    ..factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of the hypothalamus (PVN), enhanced CRHR1 mRNA and CRHR2 mRNA expression in the ..
  29. pmc Vital functions of corticotropin-releasing factor (CRF) pathways in maintenance and regulation of energy homeostasis
    Kendall M Carlin
    Department of Animal Biology, University of Pennsylvania, Philadelphia, 19104, USA
    Proc Natl Acad Sci U S A 103:3462-7. 2006
    ..A major determinate of these responses is corticotropin-releasing factor (CRF). Receptors for CRF, CRFR1 and CRFR2, have been hypothesized to play distinct roles in the alterations necessary for homeostatic maintenance...
  30. ncbi Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment
    Sergi Papiol
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    J Affect Disord 104:83-90. 2007
    ..Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment.
  31. pmc Development of alopecia areata is associated with higher central and peripheral hypothalamic-pituitary-adrenal tone in the skin graft induced C3H/HeJ mouse model
    Xingqi Zhang
    Department of Dermatology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    J Invest Dermatol 129:1527-38. 2009
    ..Nr3c1), mineralocorticoid receptor (Nr3c2), corticotropin-releasing hormone receptor types 1 and 2 (Crhr1, Crhr2), interleukin-12 (Il12), tumor necrosis factor-alpha (Tnf alpha), and estrogen receptors type-1 (Esr1) and type-2 (..
  32. ncbi Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation
    M B Müller
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Endocrinology 142:4150-3. 2001
    ..by means of RT-PCR and in situ hybridization analyses, we could provide first evidence that both CRHR1 and CRHR2 are expressed in the mouse pituitary and adrenal cortex...
  33. ncbi Expression of urocortin 2 and its inhibitory effects on intracellular ca2+ via L-type voltage-gated calcium channels in rat pheochromocytoma (PC12) cells
    Jin Tao
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, Nanjing, PR China
    Neuropsychopharmacology 31:2600-9. 2006
    ..effects of urocortin 2 on VGCC currents or [Ca(2+)](i) were not affected by astressin 2B, an antagonist of CRFR2. As calcium overload play a key role in some neuronal degenerative diseases such as Alzheimer's and Parkinson's ..
  34. pmc Antagonism of corticotrophin-releasing factor receptors in the fourth ventricle modifies responses to mild but not restraint stress
    Joanna R Miragaya
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30602, USA
    Am J Physiol Regul Integr Comp Physiol 295:R404-16. 2008
    ..MS rats infused with 3 nmol antisauvagine-30, a CRFR2 antagonist, did not lose weight in the 48 h after MS, but 0.3 nmol did not prevent weight loss in MS rats...
  35. pmc Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats
    Christina Chotiwat
    Department of Foods and Nutrition, University of Georgia, Dawson Hall, Athens, GA 30605, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1762-73. 2008
    ..Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals...
  36. ncbi Corticotropin-releasing factor receptor type 1, but not type 2, in the ventromedial hypothalamus modulates dopamine release in female rats
    Tomohiro Muramatsu
    Department of Neuropsychiatry, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka City, Osaka 545 8585, Japan
    Pharmacol Biochem Behav 85:435-40. 2006
    ..responses and is mediated through two subtypes of receptors, CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2)...
  37. ncbi Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium
    Dan Jin
    Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
    Reprod Sci 14:568-77. 2007
    ..A heterogeneous distribution of CRH-R1 variants in term labor and nonlabor myometrium might be related to the effects of CRH on contractile phenotype of myometrium at the term...
  38. pmc Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior
    Liping Zhao
    University of Texas Southwestern, Dallas, Texas 75390 8857, USA
    Mol Endocrinol 22:1403-15. 2008
    ..to stress and anxiety-like behavior, including brain-derived neurotrophic factor, the type 2 receptor for CRH (Crhr2), and Ucn 3. Moreover, transfection and EMSAs support a direct role of SF-1 in Crhr2 regulation...
  39. pmc Early weaning stress impairs development of mucosal barrier function in the porcine intestine
    Feli Smith
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, 27606, USA
    Am J Physiol Gastrointest Liver Physiol 298:G352-63. 2010
    ..pigs revealed that CRF receptor 1 (CRFr1) activation mediates barrier dysfunction and hypersecretion, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life ..
  40. pmc Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis
    Eunok Im
    Section of Inflammatory Bowel Disease and Inflammatory Bowel Disease Center, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    Gastroenterology 138:2457-67, 2467.e1-5. 2010
    ..hormone (CRH) family of peptides modulates intestinal inflammation and the CRH receptor 2 (CRHR2) suppresses postnatal angiogenesis in mice...
  41. doi Regulatory mechanism of hypothalamo-pituitary-adrenal (HPA) axis and neuronal changes after adrenalectomy in type 2 diabetes
    Sun Shin Yi
    Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 151 742, South Korea
    J Chem Neuroanat 40:130-9. 2010
    ..Additionally, mRNA expression of AVP and CRH receptors (V1aR, V1bR, CRHR1, and CRHR2) was also measured and adrenocorticotropin hormone (ACTH) immunoreactivity was surveyed by IHC to add to data ..
  42. pmc Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation
    Robert A Rissman
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
    Proc Natl Acad Sci U S A 109:6277-82. 2012
    ..Robust tau-P responses were seen in WT and CRFR2 null mice exposed to repeated stress, which were sustained at even 24 h after the final stress exposure...
  43. pmc Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: down-regulation in ulcerative colitis
    Ekaterini Chatzaki
    Neurocrine Biosciences Inc, San Diego, CA 92121, USA
    World J Gastroenterol 19:1416-23. 2013
    To assess corticotropin-releasing factor receptor 2 (CRF2) expression in the colon of healthy subjects and patients with ulcerative colitis (UC).
  44. doi Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy
    F Zhou
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Ministry of Education, Chengdu, Sichuan 610041, China
    Placenta 35:962-8. 2014
    ..Urocortin (UCN) exhibits a powerful concentration-dependent vasodilatation effect in the utero-placental-fetal unit. Our study aimed to investigate placental and serum UCN expression in ICP patients...
  45. ncbi Corticotropin-releasing factor receptor type 1 colocalizes with type 2 in corticotropin-releasing factor-containing cellular profiles in rat brain
    Jun Ming Fan
    Division of Neurobiology and Physiology, Department of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China
    Neuro Endocrinol Lett 35:417-26. 2014
    To investigate whether CRHR1 and CRHR2 are colocalized in CRH-specific neurons in rat brain.
  46. doi The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder
    Ana Martín-Blanco
    Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM, Institut d Investigació Biomèdica Sant Pau IIB Sant Pau, Av Sant Antoni Mª Claret 167, 08025, Barcelona, Spain
    Eur Arch Psychiatry Clin Neurosci 266:307-16. 2016
    ..and rs10947563-A) were more frequent in BPD subjects with history of physical abuse and emotional neglect and two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse...
  47. doi Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression
    María Belén Poretti
    Instituto de Fisiologia, Instituto de Investigaciones en Ciencias de la Salud INICSA, UNC CONICET, Facultad de Ciencias Medicas, CONICET and Universidad Nacional de Córdoba, Cordoba, Argentina
    Psychopharmacology (Berl) 233:1077-86. 2016
    ..releasing hormone (CRH) and vasopressin (AVP) are released from the hypothalamus, activate their receptors (CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropic hormone (ACTH) release from the anterior ..
  48. ncbi Mapping of the mouse corticotropin-releasing hormone receptor 2 gene (Crhr2) to chromosome 6
    J S Lesh
    Mental Health Research Institute, University of Michigan Medical School, Ann Arbor 48109 0720, USA
    Mamm Genome 8:944-5. 1997
  49. ncbi Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters
    Patricia L Seymour
    Center for Neuroendocrine Studies, University of Massachusetts, 135 Hicks Way, Amherst, MA 01003, USA
    Am J Physiol Regul Integr Comp Physiol 289:R418-R423. 2005
    ..ICV infusion of the CRF receptor subtype CRFR2-selective agonists urocortin 2 and 3 (UCN2, UCN3) inhibited sexual receptivity in hormone-primed, ovariectomized ..
  50. doi Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling
    K Kamprath
    Max Planck Institute of Psychiatry, Munich, Germany
    Genes Brain Behav 8:203-11. 2009
    ..blockade of CB(1) receptors by rimonabant in mice deficient for the CRH receptor type 1 (CRHR1(-/-)) or type 2 (CRHR2(-/-)), and in respective wild-type littermates, resulted in a sustained fear response in all genotypes...
  51. doi Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells
    Ai Yata
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Hum Reprod 24:1748-53. 2009
    ..In the present study, we investigated the effects of SCP/Ucn3 on progesterone production in cultured human granulosa-lutein cells...
  52. pmc Expression of urocortin peptides in canine myocardium and plasma
    Gemma Fraga Veloso
    Royal Dick School of Veterinary Studies, University of Edinburgh Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin EH25 9RG, UK
    Vet J 188:318-24. 2011
    Urocortin (Ucn) peptides are the endogenous ligands for the corticotropin-releasing factor type 2 receptor (CRFR2)...
  53. pmc Inheritable effect of unpredictable maternal separation on behavioral responses in mice
    Isabelle C Weiss
    Brain Research Institute, University of Zurich Swiss Federal Institute of Technology Zurich, Switzerland
    Front Behav Neurosci 5:3. 2011
    ..basic components of the hypothalamic-pituitary-adrenal axis but decreases the expression of the corticotropin releasing factor receptor 2 (CRFR2) in several nuclei of the amygdala and the hypothalamus in the brain of maternal-..
  54. doi Association of CRHR1 and CRHR2 with major depressive disorder and panic disorder in a Japanese population
    Yoshinobu Ishitobi
    Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama machi, Yufu Shi, Oita, Japan
    Am J Med Genet B Neuropsychiatr Genet 159:429-36. 2012
    ..axis, including the corticotrophin-releasing hormone (CRH) signaling via primary receptors (CRHR1 and CRHR2), is considered to play a major role for onset and recurrence in MDD and PD...
  55. pmc Chronic activation of corticotropin-releasing factor type 2 receptors reveals a key role for 5-HT1A receptor responsiveness in mediating behavioral and serotonergic responses to stressful challenge
    Adi Neufeld-Cohen
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Biol Psychiatry 72:437-47. 2012
    The corticotropin-releasing factor type 2 receptor (CRFR2) is suggested to play an important role in aiding recovery from acute stress, but any chronic effects of CRFR2 activation are unknown...
  56. doi HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters
    Sebastien Guillaume
    Inserm U1061, Montpellier, France
    J Psychiatr Res 47:259-65. 2013
    ..Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes...
  57. pmc A subset of presympathetic-premotor neurons within the centrally projecting Edinger-Westphal nucleus expresses urocortin-1
    Najmul S Shah
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Chem Neuroanat 52:25-35. 2013
    ..the major source of urocortin 1 (Ucn-1), an analog of the corticotropin-releasing factor that binds the CRFR1 and CRFR2 receptors and has been implicated in mediating homeostatic responses to stress...
  58. doi Long-term dysregulation of brain corticotrophin and glucocorticoid receptors and stress reactivity by single early-life pain experience in male and female rats
    Nicole C Victoria
    Neuroscience Institute, Georgia State University, 100 Piedmont Avenue, Room 880, Atlanta, GA 30303, United States Center for Behavioral Neuroscience, Georgia State University, 100 Piedmont Avenue, Room 880, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 38:3015-28. 2013
    ..activation and termination of the stress response, including corticotrophin releasing factor receptors (CRFR1 and CRFR2) and glucocorticoid receptor (GR)...
  59. doi Strain differences in stress-induced changes in central CRF1 receptor expression
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, Biosciences Institute, Department of Physiology, Electronic address
    Neurosci Lett 561:192-7. 2014
    ..CRF binds to CRF1 and 2 receptors (CRFR1 and CRFR2) which are expressed in both hypothalamic and extra-hypothalamic brain regions...
  60. doi CRH suppressed TGFβ1-induced Epithelial-Mesenchymal Transition via induction of E-cadherin in breast cancer cells
    Lai Jin
    Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Cell Signal 26:757-65. 2014
    ..And HEK293 cells were transiently transfected with CRHR1 or CRHR2 to explore the definite effects of CRH receptor...
  61. doi Urocortin 2 role in placental and myometrial inflammatory mechanisms at parturition
    Chiara Voltolini
    Department of Molecular and Developmental Medicine C V, R N, M T, F M S, F P, University of Siena, 53100 Siena, Italy and Medical Research Council Centre for Reproductive Health S B, J E N, University of Edinburgh, EH16 4TY Edinburgh, United Kingdom
    Endocrinology 156:670-9. 2015
    ..Placental and myometrial Ucn2 may play a role in the endocrine-inflammatory processes of parturition, representing a potential target for treating inflammation-induced obstetric complications...
  62. doi Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling
    Manuela Eisenhardt
    Behavioral Genetics Research Group, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany Institute of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Alcohol Clin Exp Res 39:752-62. 2015
    ..we were interested in alterations in the corticotrophin-releasing hormone (CRH) and receptor (CRHR1 and CRHR2) system as a prominent role of CRH in driving the postdependent state via actions in the central extended amygdala ..
  63. pmc Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats
    He ren Gao
    State Key Laboratory of Pharmaceutical Biotechnology and Department of Biological Science and Technology, School of Life Sciences, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China
    Sci Rep 6:20206. 2016
    ..Our present results demonstrate that CRF directly excites PH neurons via two CRF receptors, CRFR1 and CRFR2, and consequently increases heart rate (HR) rather than the mean arterial pressure (MAP) and renal sympathetic ..
  64. ncbi Effects of acute and chronic stress on telencephalic neurochemistry and gene expression in rainbow trout (Oncorhynchus mykiss)
    Maria Moltesen
    Section for Ecology and Evolution, Department of Biology, University of Copenhagen, Universitetsparken 15, Building 3, 4th Floor, Copenhagen Ø DK 2100, Denmark
    J Exp Biol 219:3907-3914. 2016
    ..and mRNA levels of corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), CRF receptors (CRFR1 and CRFR2), mineralocorticoid receptor (MR), glucocorticoid receptors (GR1 and GR2) and serotonin type 1A (5-HT1A)..
  65. ncbi Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
    A Contarino
    The Scripps Research Institute, Department of Neuropharmacology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 835:1-9. 1999
    ..Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS...
  66. ncbi Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: an effect mediated via R1alpha and R2beta CRH receptor subtypes and stimulation of Gq-protei
    D K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    Mol Endocrinol 14:2076-91. 2000
    ....
  67. pmc Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response
    Xiaozhong Wang
    Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:6605-10. 2002
    ..Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential ..
  68. ncbi Regulation of corticotropin-releasing hormone type 2 receptors by multiple promoters and alternative splicing: identification of multiple splice variants
    Rob D Catalano
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    Mol Endocrinol 17:395-410. 2003
    We demonstrate that multiple promoters and alternate splicing regulate expression of the human CRH receptor type 2 (CRHR2) gene...
  69. ncbi A new role for corticotropin-releasing factor receptor-2: suppression of vascularization
    Tracy L Bale
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 13:68-71. 2003
    ..Our recent data has described a novel role of corticotropin-releasing factor receptor-2 (CRFR2) as a tonic inhibitor of neovascularization...
  70. ncbi A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity
    Marilyn H Perrin
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 278:15595-600. 2003
    The heptahelical receptors for corticotropin-releasing factor (CRF), CRFR1 and CRFR2, display different specificities for CRF family ligands: CRF and urocortin I bind to CRFR1 with high affinity, whereas urocortin II and III bind to this ..
  71. ncbi Fractal dynamics of heart beat interval fluctuations in corticotropin-releasing factor receptor subtype 2 deficient mice
    Oliver Stiedl
    Fractal Physiology Group, Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Integr Physiol Behav Sci 37:311-45. 2002
    ..analysis of cardiac interbeat time series was performed in corticotropin-releasing factor receptor subtype 2 (CRFR2) deficient mice...
  72. ncbi Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold
    Tracy L Bale
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 144:2580-7. 2003
    ..These ligands function via activation of their two receptors, CRFR1 and CRFR2. CRFR1 has been shown to be the dominant receptor in activation of the hypothalamic-pituitary-adrenal axis in ..
  73. ncbi Stress-mediated heart rate dynamics after deletion of the gene encoding corticotropin-releasing factor receptor 2
    Oliver Stiedl
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Goettingen, Germany
    Eur J Neurosci 17:2231-5. 2003
    ..of the present study was to investigate the potential role of corticotropin-releasing factor receptor subtype 2 (CRFR2) in autonomic regulation of heart rate and heart rate variability under physiological conditions in conscious mice...
  74. ncbi Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes
    A Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    J Mol Cell Cardiol 35:1295-305. 2003
    ..is able to bind to two types of G-protein coupled receptors: CRF receptor type 1 (CRFR1) and CRF receptor type 2 (CRFR2), whereas, two homologues of UCN, stresscopin (SCP) or also known as urocortin III (UCNIII) and stresscopin ..
  75. pmc Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle
    Alon Chen
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:16580-5. 2006
    ..2 (Ucn 2), a member of the corticotropin-releasing factor (CRF) family, and its cognate type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle...
  76. ncbi Perfluorooctane sulfonate influences feeding behavior and gut motility via the hypothalamus
    Akihiro Asakawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Int J Mol Med 19:733-9. 2007
    ..A centrally administered corticotropin-releasing factor type 2 receptor (CRFR2) antagonist blocked PFOS-induced anorexia. These findings indicate that PFOS and PFOA influence feeding behavior...
  77. pmc Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation
    V Minas
    Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece
    Br J Cancer 97:637-45. 2007
    ..Here, we examined immunohistochemically the expression of CRH, CRHR1, CRHR2 and FasL in 47 human ovarian cancer cases...
  78. pmc Urocortin 1 inhibits rat leydig cell function
    Catherine L Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 149:6425-32. 2008
    ..We show here that Ucn 1 [a mixed CRF receptor (CRFR) type 1 and CRFR2 agonist] and the CRFR1-selective peptide Stressin 1, but not Ucn 2 or Ucn 3 (both considered selective CRFR2 ..
  79. doi Involvement of CRH receptors in urocortin-induced hyperthermia
    G Telegdy
    Department of Pathophysiology, University of Szeged, Semmelweis 1, Szeged 6701, Hungary
    Peptides 29:1937-42. 2008
    The actions of individual corticotropin-releasing hormone (CRH) receptor (CRHR1 and CRHR2) were studied on the hyperthermia caused by urocortin 1, urocortin 2 and urocortin 3 in rats...
  80. ncbi [Role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide of hypothalamus in hypermetabolism in rats with severe burn]
    Zhong yong Chen
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, The Third Military Medical University, Chongqing 400038, PR China
    Zhonghua Shao Shang Za Zhi 24:414-7. 2008
    To observe the role of corticotropin releasing factor receptor 2 antisense oligodeoxynucleotide (CRFR2ASO) of hypothalamus in hypermetabolism in rats with severe burn.
  81. doi Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder
    Martien J H Kas
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:252-9. 2010
    ..In the overlapping (human/mouse) genomic region, the CRH receptor 2 (CRHR2) gene was tested in a human case-control study...
  82. pmc Injection of Urocortin 3 into the ventromedial hypothalamus modulates feeding, blood glucose levels, and hypothalamic POMC gene expression but not the HPA axis
    Peilin Chen
    Department of Medicine and Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 298:E337-45. 2010
    ..Ucn 3) is a corticotropin-releasing factor (CRF)-related peptide with high affinity for the type 2 CRF receptor (CRFR2)...
  83. pmc Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets
    M O Huising
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocrinology 152:138-50. 2011
    ..Ucn 3 activates the CRF type-2 receptor (CRFR2) but does not activate the type-1 receptor (CRFR1), which was recently demonstrated on β-cells...
  84. doi Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration
    Danijela Markovic
    Division of Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick Gibbet Hill Road, Coventry, CV4 7AL, UK
    Biochim Biophys Acta 1813:896-907. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  85. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
    ..Our data suggest that, in placenta, CRH produced locally regulates GLUT1 and GLUT3 expression, CRHR1 and CRHR2-mediated differential regulation of GLUT1 and GLUT3 expression...
  86. doi Estrogenic action on arterial smooth muscle: permissive for maintenance of CRHR2 expression
    Shan Wang
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 153:1915-24. 2012
    ..The aim of this study was to investigate whether estrogens modulate Ucn/CRH receptor type 2 (CRHR2) expression in vascular smooth muscle, thereby leading to vasodilation...
  87. doi Asthma and bronchodilator responsiveness are associated with polymorphic markers of ARG1, CRHR2 and chromosome 17q21
    Hing Yee Sy
    Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N T, Hong Kong
    Pharmacogenet Genomics 22:517-24. 2012
    ..A genetic study for spirometric parameters helps to predict the responses to this antiasthma treatment. This study investigated the relationship between asthma and bronchodilator responsiveness (BDR) and eight asthma genes...
  88. doi Exaggerated anorexigenic response to restraint stress in A(y) mice is associated with elevated CRFR2 mRNA expression in the hypothalamus
    N M Bazhan
    Laboratory of Physiological Genetics, Institute of Cytology and Genetics, Lavrentjeva av 10, Novosibirsk, 630090, Russian Federation Electronic address
    Physiol Behav 120:19-25. 2013
    ..Gene expression of CRFR2 was elevated in A(y)/a mice with genotype differences particularly manifested immediately after the restraint...
  89. doi Corticotropin-releasing factor receptor type-2 is involved in the cocaine-primed reinstatement of cocaine conditioned place preference in rats
    Xiaowei Guan
    Department of Human Anatomy, Nanjing Medical University, Nanjing 210029, China Electronic address
    Behav Brain Res 258:90-6. 2014
    Here we explored the in vivo role of brain corticotropin-releasing factor receptor type-2 (CRFR2) in cocaine-primed reinstatement of drug seeking...
  90. doi Presence and distribution of urocortin and corticotrophin-releasing hormone receptors in the bovine thyroid gland
    C Squillacioti
    Dipartimento di Medicina Veterinaria e Produzioni Animali, Universita di Napoli Federico II, Via Federico Delpino, 1 80137, Napoli, Italia
    Anat Histol Embryol 43:429-34. 2014
    ..CRH family peptides are mediated via two types of G-protein-coupled receptors, CRH type 1 (CRHR1) and CRH type 2 (CRHR2)...
  91. pmc Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats
    Weidong Yong
    Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences CAMS and Peking Union Medical College PUMC, Beijing, China Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
    Alcohol Clin Exp Res 38:1275-83. 2014
    ..The Crhr2 gene maps to a quantitative trait locus (QTL) for alcohol preference on chromosome 4 previously identified in ..
  92. doi CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors
    Vandana Veenit
    Laboratory of Behavioral Genetics, Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Psychiatr Res 53:1-7. 2014
    ..comprising juvenility and puberty - is effective in inducing long-lasting changes in the expression of CRHR1 and CRHR2 in the hippocampus and amygdala, and whether treating animals with a CRHR1 antagonist following stress exposure ..
  93. pmc Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration
    Christopher O Boyson
    Department of Psychology, Tufts University, Medford, Massachusetts 02155, and Departments of Psychiatry, Pharmacology, and Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02110
    J Neurosci 34:6659-67. 2014
    ..The current study examines the role of corticotropin releasing factor receptor subtypes 1 and 2 (CRFR1, CRFR2) within the ventral tegmental area (VTA) during social defeat stress...
  94. doi Mediators involved in the hyperthermic action of neuromedin U in rats
    G Telegdy
    Department of Pathophysiology, University of Szeged, Szeged, Hungary Neuroscience Research Group of the Hungarian Academy of Science, Faculty of Medicine, University of Szeged, Szeged, Hungary Electronic address
    Regul Pept 192:24-9. 2014
    ..The results demonstrated that, when injected into the lateral brain ventricle NmU increased the body temperature, mediated by CRHR1 and CRHR2, dopamine and muscarinic cholinergic receptors. The final pathway involves prostaglandin.
  95. doi Differential stress response in rats subjected to chronic mild stress is accompanied by changes in CRH-family gene expression at the pituitary level
    Magdalena Kolasa
    Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    Peptides 61:98-106. 2014
    ..1, Ucn2-urocortin 2, Ucn3-urocortin 3), CRH receptors (Crhr1-corticotropin-releasing hormone receptor 1, Crhr2-corticotropin-releasing hormone receptor 2) and Crhbp (corticotropin-releasing factor binding protein) in the ..
  96. doi The effects of CRF and urocortins on the hippocampal glutamate release
    Zsolt Bagosi
    Department of Pathophysiology, Faculty of Medicine, University of Szeged, Hungary Electronic address
    Neurochem Int 90:67-71. 2015
    ..In order to investigate the participation of CRF receptors (CRFR1 and CRFR2) in this process, hippocampal slices were pretreated with antalarmin, a selective antagonist of CRFR1 or astressin ..
  97. pmc Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner
    Natalia J Grundwald
    The Roslin Institute and R D SVS, University of Edinburgh, Easter Bush Campus, Midlothian, EH25 9RG, UK
    Psychoneuroendocrinology 62:204-16. 2015
    ..Moreover, Crh receptor-1 (Crhr1) mRNA expression was significantly increased, whereas Crhr2 mRNA was significantly decreased in discrete regions of the amygdala in F2 PNS males compared with controls, with ..
  98. doi Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics
    Yair Shemesh
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Nat Neurosci 19:1489-1496. 2016
    ..MeA-specific knockdown of Crfr2 (Crhr2) in adulthood recapitulated this phenotype...
  99. pmc Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes
    Justyna M Wierzbicka
    Department of Histology, Medical University of Gdansk, Poland
    Mol Cell Endocrinol 437:312-322. 2016
    ..in stimulating the expression of neuropeptides, CRF, urocortins and POMC, and their receptors, CRFR1, CRFR2, MC1R, MC2R, MC3R and MC4R...
  100. doi CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery
    M J A G Henckens
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Mol Psychiatry . 2016
    ..Previously, we observed abnormal expression of corticotropin-releasing factor receptor type 2 (CRFR2) to be associated with post-traumatic stress disorder (PTSD)-like symptoms...

Research Grants31

  1. Marc R Montminy; Fiscal Year: 2014
    ..and biologically characterized multiple components of this system including two receptor genes (CRFR1 and CRFR2), a CRF binding protein and three urocortins (Ucn 1, 2 and 3)...
  2. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
    ..factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
  3. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..addictive behavior - acquisition, binge, reinstatement - to determine the role for CRF receptor subtypes (CRFR1 or CRFR2)and sex in these effects...
  4. Central neural function of Urocortin 3 in regulating energy balance
    Chien Li; Fiscal Year: 2013
    ..The receptor for Ucn 3, the type 2 CRF receptor (CRFR2), is highly expressed in the VMH and its expression is regulated by the energy status of the animals...
  5. Tracy L Bale; Fiscal Year: 2015
    ..Utilizing CRF receptor-2 (CRFR2) deficient mice in which disruption of normal stress neurocircuitry prevents the recruitment and promotion of ..
  6. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..Hence, OT neurons in the PVN selectively express CRF type 2 receptors (CRFR2) and send oxytocinergic input to the BNST, where OT axons and terminals also express CRFR2...
  7. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
    ..by disruption of signaling via the type 1 corticotropin-releasing factor receptor (CRFR1) and exaggerated in CRFR2-deficient mice...
  8. CRF Modulation of NMDA Currents and Behavior in the VTA
    Matthijs Verhage; Fiscal Year: 2013
    ..The main goal of this project is to elucidate the role of CRFR1 and CRFR2 in promoting stress-enhanced relapse to cocaine seeking...
  9. Bimolecular interactions of CRF ligands and receptors
    Abdul Abou Samra; Fiscal Year: 2006
    ..an oxidation-resistant radio labeled sauvagine analog (YQLS), that can be covalently cross linked to CRFR1 and CRFR2, using a chemical cross linking agent that cross links lysine residues...
  10. Urocortin, Dorsal Raphe & Ethanol-induced Hypothermia
    VICTORIA TUREK; Fiscal Year: 2005
    ..The DRN contains corticotropin-releasing factor type 2 receptors (CRFR2) that are responsive to Ucn, a peptide synthesized in the EW...
  11. Perioculomotor area and alcohol
    Andrey E Ryabinin; Fiscal Year: 2010
    ..These studies will provide novel important information indicating how these recently identified neurons robustly regulate alcohol intake. ..
  12. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2008
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  13. Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamus
    RORY MCCRIMMON; Fiscal Year: 2008
    ..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
  14. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  15. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  16. ROLE OF UROCORTIN IN MAMMALIAN BRAIN AND PITUITARY
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ..urocortin, is 43 percent identical to CRH and binds to both of its receptors, albeit with a higher affinity to CRHR2. Because CRH and urocortin can bind to and activate both CRH receptors, iv or icv administration of urocortin ..
  17. Somatostatin Receptor-Selective Agonists and Antagonists
    Jean Rivier; Fiscal Year: 2006
    ..abstract_text> ..
  18. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  19. Role of Intracellular ABeta in Tau Pathology
    ROBERT RISSMAN; Fiscal Year: 2003
    ..The goals of the proposed studies are to investigate the role of in vitro intracellular beta-amyloid (ABeta) as a potential initiator of the cascade leading to caspase proteolysis of tau. ..
  20. SYNTHETIC SUBSTANCES CONTROLLING REPRODUCTION
    Jean Rivier; Fiscal Year: 2005
    ..Such molecules are not presently available to academic researchers. As in the past twenty years, collaborations with academic colleagues will be initiated, to maximize the impact of this research. ..
  21. Corticotropin-Releasing Hormone-Binding Protein
    AUDREY SEASHOLTZ; Fiscal Year: 2004
    ....
  22. NEUROANATOMICAL SUBSTRATES OF ALCOHOL-INDUCED AMNESIA
    Andrey Ryabinin; Fiscal Year: 2001
    ..Taken together, these studies will provide valuable insight at several levels of analysis of alcohol~s action on cognitive functions and eventually allow to start understanding of the mechanisms involved in alcohol-induced amnesia. ..
  23. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  24. Central neural function of Urocortin 3 in regulating energy balance
    Chien Li; Fiscal Year: 2008
    ..The receptor for Ucn 3, the type 2 CRF receptor (CRFR2), is highly expressed in the VMH and its expression is regulated by the energy status of the animals...
  25. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  26. Urocortin III: Regulation and Function in the Islet
    Chien Li; Fiscal Year: 2005
    ..The additional knowledge and research skills acquired from the application, together with previous background, will enable the applicant to study complicated, multifaceted metabolic disorders such as diabetes mellitus ..
  27. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  28. Neural Analysis of Maternal Aggression
    STEPHEN GAMMIE; Fiscal Year: 2006
    ..Basic research into sex differences in aggression, then, is important to understanding the biological underpinnings of sex and gender differences in social behavior, health, and disease. ..
  29. Modulation of BNST 5-HT responses by corticosterone
    SAYAMWONG HAMMACK; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  30. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..