CRHR1

Summary

Gene Symbol: CRHR1
Description: corticotropin releasing hormone receptor 1
Alias: CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L, corticotropin-releasing factor receptor 1, CRH receptor 1, corticotropin-releasing factor type 1 receptor, seven transmembrane helix receptor
Species: human

Top Publications

  1. ncbi Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1
    N Heinrich
    Forschungsinstitut fur Molekulare Pharmakologie, Berlin, Germany
    Endocrinology 139:651-8. 1998
  2. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
  3. ncbi Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas
    E Karteris
    The Sir Quinton Hazel Research Centre for Molecular Medicine, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 88:363-70. 2003
  4. pmc Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients
    Ananda B Amstadter
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Dis Markers 30:89-99. 2011
  5. pmc Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning
    Ryan Bogdan
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:13246-54. 2011
  6. ncbi Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors
    Sharla F Young
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, CRC 1 3330, 10 Center Drive, MSC 1103, Bethesda, MD 20892 1103, USA
    Cell Mol Neurobiol 27:439-61. 2007
  7. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
  8. ncbi Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin
    Kelly L Parham
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 145:3971-83. 2004
  9. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
  10. pmc Mapping structural determinants within third intracellular loop that direct signaling specificity of type 1 corticotropin-releasing hormone receptor
    Anu Punn
    Department of Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    J Biol Chem 287:8974-85. 2012

Research Grants

  1. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
  2. Richard L Hauger; Fiscal Year: 2016
  3. Marc R Montminy; Fiscal Year: 2014
  4. John R Mantsch; Fiscal Year: 2014
  5. Sex differences in the corticotropin-releasing factor receptor
    DEBRA WAXLER BANGASSER; Fiscal Year: 2010
  6. Victoria B Risbrough; Fiscal Year: 2014
  7. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2012
  8. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
  9. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
  10. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012

Detail Information

Publications228 found, 100 shown here

  1. ncbi Corticotropin-releasing factor (CRF) agonists stimulate testosterone production in mouse leydig cells through CRF receptor-1
    N Heinrich
    Forschungsinstitut fur Molekulare Pharmakologie, Berlin, Germany
    Endocrinology 139:651-8. 1998
    ....
  2. ncbi The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology
    Edward W Hillhouse
    The Leeds Institute of Genetics, Health and Therapeutics, The University of Leeds, Leeds LS2 9NL, UK
    Endocr Rev 27:260-86. 2006
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease...
  3. ncbi Reduced expression of corticotropin-releasing hormone receptor type-1 alpha in human preeclamptic and growth-restricted placentas
    E Karteris
    The Sir Quinton Hazel Research Centre for Molecular Medicine, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    J Clin Endocrinol Metab 88:363-70. 2003
    ..These findings might suggest that changes in receptor expression may contribute toward dysregulation of the dynamic balance controlling vascular resistance...
  4. pmc Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients
    Ananda B Amstadter
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, 23298 0126, USA
    Dis Markers 30:89-99. 2011
    ..the hypothalamic-pituitary-adrenal (HPA) axis, such as corticotrophin-releasing hormone type 1 receptor gene (CRHR1), have been implicated in traumatic-stress related phenotypes but have yet to be studied in relation to PTSD...
  5. pmc Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning
    Ryan Bogdan
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:13246-54. 2011
    ..emerging data indicate that genetic variation within the corticotropin-releasing hormone type 1 receptor gene (CRHR1) at rs12938031 may promote psychopathology, particularly in the context of stress...
  6. ncbi Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors
    Sharla F Young
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development NIH, CRC 1 3330, 10 Center Drive, MSC 1103, Bethesda, MD 20892 1103, USA
    Cell Mol Neurobiol 27:439-61. 2007
    ..and interaction of pituitary VP V1b receptor (V1bR) and corticotropin releasing hormone receptor type 1 (CRHR1) are critical for hypothalamic pituitary adrenal (HPA) axis adaptation, but it is unknown whether this involves ..
  7. doi Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Endocrinology 153:1464-71. 2012
    ..Our data suggest that, in placenta, CRH produced locally regulates GLUT1 and GLUT3 expression, CRHR1 and CRHR2-mediated differential regulation of GLUT1 and GLUT3 expression...
  8. ncbi Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin
    Kelly L Parham
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Endocrinology 145:3971-83. 2004
    ..the full genomic organization of the human gene for the corticotropin-releasing factor (CRF) receptor type 1 (CRFR1), with complete mapping of exons 1-14. The 5' flanking region (2...
  9. ncbi Corticotropin-releasing hormone receptor type 1 and type 2 mediate differential effects on 15-hydroxy prostaglandin dehydrogenase expression in cultured human chorion trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 148:3645-54. 2007
    ..We found that both CRHR1 and CRHR2 were localized in cultured chorion trophoblast cells, with CRH-R1alpha, R1beta, R1c, R1e, and R1f and ..
  10. pmc Mapping structural determinants within third intracellular loop that direct signaling specificity of type 1 corticotropin-releasing hormone receptor
    Anu Punn
    Department of Endocrinology and Metabolism, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    J Biol Chem 287:8974-85. 2012
    ..These data uncovered unexpected roles for key amino acids within the highly conserved hydrophobic N- and C-terminal microdomains of IC3 in the coordination of CRH-R1 signaling activity...
  11. pmc Expression of corticotropin releasing factor receptor type 1 (CRF1) in the human gastrointestinal tract and upregulation in the colonic mucosa in patients with ulcerative colitis
    Pu Qing Yuan
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, CA 90073, USA
    Peptides 38:62-9. 2012
    ..The increase of CRF(1) IR cells prominently in macrophages of the sigmoid colonic mucosa of UC patients provides anatomical support for a role of CRF(1) signaling in modulating the immune-inflammatory process of UC...
  12. ncbi Cell-type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: phospholipase C-mediated responses in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells
    Frank M Dautzenberg
    Johnson and Johnson Research and Development, CNS Research, Turnhoutseweg 30, Beerse, Belgium
    Biochem Pharmacol 68:1833-44. 2004
    The human corticotropin-releasing factor (hCRF) receptors CRF1 and CRF2(a) couple to the Gs protein. It has been postulated that CRF receptors may also signal through phospholipase C (PLC)...
  13. pmc Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour
    Binhai Cong
    Department of Physiology, Second Military Medical University, Shanghai, PR China
    Reprod Biol Endocrinol 7:43. 2009
    ..We hypothesized that the expression of CRH receptors in myometrium might be changed during pregnancy and labour...
  14. pmc Cortagine, a specific agonist of corticotropin-releasing factor receptor subtype 1, is anxiogenic and antidepressive in the mouse model
    Hossein Tezval
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 101:9468-73. 2004
    ..In contrast to its anxiogenic actions, cortagine reduced significantly the immobility time in the FST as described for antidepressive drugs. Thus, cortagine combines anxiogenic properties with antidepressive effects in the FST...
  15. ncbi Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria
    Nikoletta Papadopoulou
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Invest Dermatol 125:952-5. 2005
    ..The lichen simplex samples had high expression of CRH-R1, but low HDC. These results implicate CRH-R in chronic urticaria, which is often exacerbated by stress...
  16. doi Activation of corticotropin-releasing factor receptor 1 selectively inhibits CaV3.2 T-type calcium channels
    Jin Tao
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Mol Pharmacol 73:1596-609. 2008
    ..by which CRF receptors mediate their widespread effects, and here we report that the native CRF receptor 1 (CRFR1) endogenous to the human embryonic kidney 293 cells can functionally couple to mammalian Ca(V)3...
  17. doi An angiotensin-1 converting enzyme polymorphism is associated with allostatic load mediated by C-reactive protein, interleukin-6 and cortisol
    Alicia K Smith
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
    Psychoneuroendocrinology 34:597-606. 2009
    ..Polymorphisms in angiotensin-1 converting enzyme (ACE), corticotropin-releasing hormone receptor 1 (CRHR1), and serotonin receptors (HTR3A and HTR4) were associated with AL (p=0.0007-0...
  18. doi Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding
    Kostas Gkountelias
    Department of Pharmacology, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
    Mol Pharmacol 75:793-800. 2009
    ..This is the first time that a specific region of CRF(1) has been implicated in detailed interactions between the receptor and the amino-terminal portion of peptides belonging to the CRF family...
  19. pmc Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model
    S Vincent Wu
    CURE, Building 115, Room 217, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 152:126-37. 2011
    ....
  20. ncbi Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin
    Hong Tu
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 21:700-11. 2007
    ..Both receptors led to a significant increase of binding and endocytosis of radiolabeled urocortin. CRHR1-mediated urocortin endocytosis was blocked by astressin (antagonist for both CRHRs), whereas CRHR2-mediated ..
  21. doi Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation
    Sam R J Hoare
    Emerging Technologies Biomedical Research and Innovative Discovery Group, Neurocrine Biosciences Inc, 12790 El Camino Real, San Diego, CA 92130, USA
    Mol Pharmacol 73:1371-80. 2008
    ....
  22. ncbi A placental clock controlling the length of human pregnancy
    M McLean
    Maternal Health Research Centre, John Hunter Hospital, Newcastle, NSW, Australia
    Nat Med 1:460-3. 1995
    ....
  23. pmc Expression cloning of a human corticotropin-releasing-factor receptor
    R Chen
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:8967-71. 1993
    ..We also describe an alternatively spliced form of the receptor which includes an insert of 29 amino acids in the first intracellular loop...
  24. ncbi Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors
    N Vita
    Sanofi Elf Bio Recherches, Labege, France
    FEBS Lett 335:1-5. 1993
    ..A 2.7 kb mRNA coding for the CRF receptor could be detected in AtT20 cells and human cortex tissue. PCR analysis also detected the receptor transcript in human pituitary, brainstem, and testis...
  25. ncbi A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes
    D K Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    Mol Endocrinol 13:2189-202. 1999
    ..Furthermore, CRH failed to stimulate inositol trisphosphate production. Coexpression studies between the CRH-R1d or CRH-R1alpha showed that this receptor does not play a role as a dominant negative receptor for CRH...
  26. pmc Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    K Lewis
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:7570-5. 2001
    ..Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors...
  27. ncbi Expression, purification, and characterization of a soluble form of the first extracellular domain of the human type 1 corticotropin releasing factor receptor
    M H Perrin
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    J Biol Chem 276:31528-34. 2001
    The first extracellular domain (ECD-1) of the corticotropin releasing factor (CRF) type 1 receptor, (CRFR1), is important for binding of CRF ligands...
  28. ncbi Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression
    A Pisarchik
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    FASEB J 15:2754-6. 2001
    ..We suggest that a polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, and external stress (UV), and that cAMP-dependent pathways and TPA may regulate CRH-R1...
  29. ncbi CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway
    Grazia Graziani
    Department of Neuroscience, University of Rome Tor Vergata, Italy
    Endocrinology 143:807-13. 2002
    ..Experiments with the PKA inhibitor 14-22 amide and forskolin, as well as the measurement of intracellular cAMP, suggested the downstream involvement of cAMP-PKA pathway in CRH-induced inhibition of Ishikawa cell growth...
  30. ncbi Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term
    B Wetzka
    Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Exp Clin Endocrinol Diabetes 111:154-61. 2003
    ..b>CRH receptor 1 mRNA was detected in all tissues investigated by RT-PCR, whereas CRH receptor 2 mRNA was restricted to ..
  31. pmc Molecular and functional characterization of novel CRFR1 isoforms from the skin
    Alexander Pisarchik
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Eur J Biochem 271:2821-30. 2004
    In our continued studies on corticotropin releasing factor receptor (CRFR1) signaling in the skin, we tested functional activity of CRFR1alpha, e, f, g and h isoforms after transfection to COS cells...
  32. ncbi Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells
    Doreen Wietfeld
    Institute of Molecular Pharmacology, Robert Rossle Strasse 10, Berlin 13125, Germany
    J Biol Chem 279:38386-94. 2004
    ..Corresponding to a high and low affinity ligand binding site, sauvagine and other peptidic CRFR1 ligands evoked high and low potency responses of G protein activation, differing by 64-fold in their EC(50) values ..
  33. ncbi Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:1075-82. 2004
    ..b>CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and ..
  34. ncbi Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization
    Thalia Teli
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 19:474-90. 2005
    ..Based on our identification of key amino acid(s) for GRK-dependent phosphorylation, we demonstrate the importance of the CRH-R1alpha carboxyl tail for regulation of receptor activity...
  35. ncbi Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
    J Treutlein
    Molecular Genetics Laboratory and Department of Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Mol Psychiatry 11:594-602. 2006
    To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, ..
  36. ncbi Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression
    Zhongchun Liu
    College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    Neurosci Lett 404:358-62. 2006
    ..In this article, whether genetic variations in the corticotropin-releasing hormone receptor1 (CRHR1) gene might be associated with increased susceptibility to major depression was studied by using a gene-based ..
  37. ncbi Identification of signaling molecules mediating corticotropin-releasing hormone-R1alpha-mitogen-activated protein kinase (MAPK) interactions: the critical role of phosphatidylinositol 3-kinase in regulating ERK1/2 but not p38 MAPK activation
    Anu Punn
    Endocrinology and Metabolism, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 20:3179-95. 2006
    ..In conclusion, a complex signaling network appears to mediate CRH-R1alpha-MAPK interactions; PI3-K might play a critical role in the regulation of CRH-R1alpha signaling selectivity and cellular responses...
  38. ncbi Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders
    Zhongchun Liu
    Department of Psychiatry, Renmin Hospital, Wuhan University, Wuhan, PR China
    Neurosci Lett 414:155-8. 2007
    ..the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin-releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD...
  39. ncbi Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use
    Dorothea Blomeyer
    Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 63:146-51. 2008
    Recent animal research suggests that alterations in the corticotropin releasing hormone receptor 1 (CRHR1) may lead to heavy alcohol use following repeated stress...
  40. pmc Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation
    V Minas
    Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece
    Br J Cancer 97:637-45. 2007
    ..Here, we examined immunohistochemically the expression of CRH, CRHR1, CRHR2 and FasL in 47 human ovarian cancer cases...
  41. ncbi Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometrium
    Dan Jin
    Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
    Reprod Sci 14:568-77. 2007
    ..A heterogeneous distribution of CRH-R1 variants in term labor and nonlabor myometrium might be related to the effects of CRH on contractile phenotype of myometrium at the term...
  42. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  43. doi Differential regulation of prostaglandin production mediated by corticotropin-releasing hormone receptor type 1 and type 2 in cultured human placental trophoblasts
    Lu Gao
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Endocrinology 149:2866-76. 2008
    ....
  44. doi Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
    Martin E Keck
    Max Planck Institute of Psychiatry, Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008
    ..susceptibility to anxiety disorders in humans, we genotyped 71 single nucleotide polymorphisms (SNPs) in CRH, CRHR1, CRHR2, AVP, AVPR1A, AVPR1B in a German sample from Munich with patients suffering from panic disorder and matched ..
  45. doi Structural determinants critical for localization and signaling within the seventh transmembrane domain of the type 1 corticotropin releasing hormone receptor: lessons from the receptor variant R1d
    Danijela Markovic
    Endocrinology and Metabolism, Clinical Sciences Institute, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 22:2505-19. 2008
    ..This mechanism appears to involve accelerated CRH-R2beta endocytosis...
  46. pmc Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1
    Augen A Pioszak
    Laboratory of Structural Sciences, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 283:32900-12. 2008
    The bimolecular interaction between corticotropin-releasing factor (CRF), a neuropeptide, and its type 1 receptor (CRFR1), a class B G-protein-coupled receptor (GPCR), is crucial for activation of the hypothalamic-pituitary-adrenal axis ..
  47. pmc CRF1 receptor splicing in epidermal keratinocytes: potential biological role and environmental regulations
    Michal A Zmijewski
    Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cell Physiol 218:593-602. 2009
    Corticotropin releasing factor receptor type 1 (CRF1), a coordinator of the body responses to stress, is also expressed in human skin, where it undergoes alternative splicing...
  48. doi Association between CRHR1 polymorphism and improved lung function in response to inhaled corticosteroid in patients with COPD
    Woo J Kim
    Department of Internal Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea
    Respirology 14:260-3. 2009
    ..An association between sequence variants in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene and improved lung function in asthmatics treated with inhaled corticosteroids was reported recently...
  49. doi Expression and subcellular localization of CRH and its receptors in human endometrial cancer
    Fiorella Miceli
    Institute of Pharmacology, Catholic University School of Medicine, Largo Francesco Vito 1, 00168 Rome, Italy
    Mol Cell Endocrinol 305:6-11. 2009
    ..Positive correlations were found between CRH-R1 and PR expression, as well as between CRH-R2 cytoplasmic pattern and more advanced FIGO stage disease, respectively...
  50. pmc Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity
    Audrey R Tyrka
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, Rhode Island 02906, USA
    Biol Psychiatry 66:681-5. 2009
    Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression...
  51. pmc Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension
    Guilherme Polanczyk
    Department of Psychology and Neuroscience, Institute for Genome Sciences and Policy, Duke University, 2020 W Main St, Ste 201, Durham, NC 27708, USA
    Arch Gen Psychiatry 66:978-85. 2009
    ..a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (..
  52. pmc H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, USA
    Addict Biol 15:1-11. 2010
    ..genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) polymorphism, and negative events. CRHR1 and at least four other genes are located at 17q21...
  53. pmc The CRF system, stress, depression and anxiety-insights from human genetic studies
    E B Binder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:574-88. 2010
    ..In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience...
  54. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
    ..been separately identified in the stress-sensitive serotonergic (5-HTTLPR) and corticotropin-releasing hormone (CRHR1) systems...
  55. pmc Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine Atlanta, GA, USA
    Front Behav Neurosci 3:41. 2009
    Variations of the corticotropin-releasing hormone receptor 1 (CRHR1) gene appear to moderate the development of depression after childhood trauma. Depression more frequently affects women than men...
  56. doi Distinct distribution of corticotropin releasing factor receptors in human breast cancer
    A Kaprara
    Anticancer Hospital Theagenio, Simeonidi 2, 54639 Thessaloniki, Greece
    Neuropeptides 44:355-61. 2010
    ..CRF receptors could serve as targets of endogenous ligands expressed in the tumor microenvironment, regulating cancer growth...
  57. pmc NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist
    Christy Rani R Grace
    Structural Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 285:38580-9. 2010
    ..Rivier, C., Perrin, M., Koerber, S. C., Sutton, S., Corrigan, A., Lahrichi, S. L., Craig, A. G., Vale, W., and Rivier, J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 10575-10579)...
  58. pmc Moderation of the association between childhood maltreatment and neuroticism by the corticotropin-releasing hormone receptor 1 gene
    Colin G DeYoung
    University of Minnesota, USA
    J Child Psychol Psychiatry 52:898-906. 2011
    ..Variation in three polymorphisms of the CRHR1 gene has been found to moderate the association of childhood maltreatment with depression, and we hypothesized ..
  59. doi Prediction of the risk of comorbid alcoholism in schizophrenia by interaction of common genetic variants in the corticotropin-releasing factor system
    Katja Ribbe
    Division of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Arch Gen Psychiatry 68:1247-56. 2011
    ..Prediction of persons at risk for AUD is crucial for future preventive and therapeutic strategies...
  60. pmc A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 156:960-8. 2011
    ..depression and substance dependence, possibly mediated by the corticotropin-releasing hormone type 1 receptor (CRHR1)...
  61. pmc Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology
    Dante Cicchetti
    Mt Hope Family Center, University of Rochester, NY, USA
    Dev Psychopathol 23:1125-38. 2011
    ..Variation in the corticotropin releasing hormone receptor 1 (CRHR1) TAT haplotype and serotonin transporter linked polymorphic region (5-HTTLPR) was determined in a sample of ..
  62. pmc Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing
    David T Hsu
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:3253-60. 2012
    ..Recent reports suggest that GG-homozygous individuals of a single nucleotide polymorphism (rs110402) in the CRH receptor 1 (CRHR1) gene show behavioral and neuroendocrine evidence of stress vulnerability...
  63. doi Structure of class B GPCR corticotropin-releasing factor receptor 1
    Kaspar Hollenstein
    Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City AL7 3AX, UK
    Nature 499:438-43. 2013
    ..This structure provides a model for all class B GPCRs and may aid in the design of new small-molecule drugs for diseases of brain and metabolism. ..
  64. ncbi Human corticotropin-releasing hormone receptor: differences in subtype expression between pregnant and nonpregnant myometria
    D Grammatopoulos
    Sir Quinton Hazell Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    J Clin Endocrinol Metab 83:2539-44. 1998
    ..These findings suggest that CRH receptor expression plays an important modulatory role in myometrial and possibly in cervical function...
  65. ncbi Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity
    Nikolleta Papadopoulou
    Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, The University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
    Mol Endocrinol 18:624-39. 2004
    ..Phosphorylation by PKA prevents maximal coupling of the CRH-R1alpha to Gq-protein, and thereby reduces activation of ERK 1/2...
  66. ncbi Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom Street, Wellman 501, Boston, MA 02114 2696, USA
    FEBS Lett 579:803-7. 2005
    ..Fluphenazine, a calmodulin antagonist, enhances PTH-mediated accumulation of total inositol phosphates, suggesting that calmodulin regulates signaling via phospholipase C...
  67. ncbi Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm
    Alejandro R Ayala
    Pediatric Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 89:5729-37. 2004
    CRH is a main regulator of the stress response. This neuropeptide and its specific receptors, CRHR-1 and CRHR-2, are disseminated throughout the central nervous system...
  68. ncbi Vasopressin and oxytocin neurones of hypothalamic supraoptic and paraventricular nuclei co-express mRNA for Type-1 and Type-2 corticotropin-releasing hormone receptors
    H Arima
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20893, USA
    J Neuroendocrinol 12:833-42. 2000
    The presence of corticotropin-releasing hormone (CRH) receptors type-1 (CRHR-1) and type-2 (CRHR-2alpha) in the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei, and the effects of i.c.v...
  69. ncbi Chromaffin cell function and structure is impaired in corticotropin-releasing hormone receptor type 1-null mice
    M Yoshida-Hiroi
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 7:967-74. 2002
    ..CRH receptor type 1 (CRHR1)-deficient mice demonstrate alterations in behavior, impaired stress responses with adrenocortical insufficiency ..
  70. pmc Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain
    Kristen L Brunson
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Exp Neurol 176:75-86. 2002
    ..CRH-expressing cells and their target neurons possessing CRH receptors (CRF1 and CRF2) are distributed throughout the limbic system, but little is known about the regulation of limbic CRH ..
  71. ncbi Expression of type 1 corticotropin-releasing hormone (CRH) receptor mRNA in the hypothalamic paraventricular nucleus following restraint stress in CRH-deficient mice
    Shinya Makino
    Second Department of Internal Medicine, Kochi Medical School, Okoh cho, Nankoku City, Kochi 783 8505, Japan
    Brain Res 1048:131-7. 2005
    ..various types of stress increase type 1 corticotropin-releasing hormone (CRH) receptor (currently abbreviated to CRF1 receptor) mRNA in the hypothalamic paraventricular nucleus (PVN) of rats, but not mice...
  72. doi Corticotropin-releasing hormone receptor 1 coexists with endothelin-1 and modulates its mRNA expression and release in rat paraventricular nucleus during hypoxia
    J J He
    Division of Neurobiology and Physiology, College of Life Sciences, Zhejiang University School of Medicine, Zijingang Campus, Hangzhou, China
    Neuroscience 152:1006-14. 2008
    To determine whether corticotropin-releasing hormone receptor 1 (CRHR1) coexists with endothelin-1 (ET-1) in rat paraventricular nucleus (PVN), ET-1 expression and its regulation by CRH and CRHR1 under hypoxia, rats were exposed to ..
  73. ncbi Central type 2 corticotropin-releasing hormone receptor mediates hypothalamic-pituitary-adrenocortical axis activation in the rat
    Hiroshi Maruyama
    Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kochi, Japan
    Neuroendocrinology 86:1-16. 2007
    In an attempt to clarify the role of the type 2 corticotropin-releasing hormone (CRH) receptor (CRHR-2) in the brain in activation of the hypothalamic-pituitary-adrenocortical axis, we conducted experiments using male Wistar rats...
  74. doi Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population
    Hans J├Ârgen Grabe
    Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:1483-93. 2010
    ..two studies have reported an interaction between childhood abuse and the TAT-haplotype of the CRH-Receptor Gene (CRHR1) connecting childhood adversities and genetic susceptibility to adult depression...
  75. ncbi Decreased type 2 corticotropin-releasing hormone receptor mRNA expression in the ventromedial hypothalamus during repeated immobilization stress
    S Makino
    Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
    Neuroendocrinology 70:160-7. 1999
    ..Changes in type 2 CRH receptor (CRHR-2) mRNA in the ventromedial hypothalamus (VMH), a possible target of anorectic CRH effect, were also examined...
  76. ncbi Corticotropin-releasing factor receptor expression in the pituitary of fetal sheep after lesion of the hypothalamic paraventricular nucleus
    D A Myers
    Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Endocrinology 140:4292-9. 1999
    ..performed using a digoxigenin-labeled ovine POMC complementary RNA, together with a 35S-labeled ovine CRF type I (CRF1) receptor complementary RNA, to localize and quantify CRF1 receptor mRNA in POMC-hybridizing cells...
  77. ncbi Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes
    Lin Lu
    Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
    J Neurochem 84:1378-86. 2003
    ..These results suggest that the CRF receptor antagonist, particularly the CRF receptor subtype 1 antagonist, might be of some value in the treatment of cocaine addiction and cocaine-related behavioral disorders...
  78. pmc The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
    T Z Baram
    Department of Pediatrics, University of California, Irvine 92697 4475, USA
    Brain Res 770:89-95. 1997
    ..Both of the characterized members of the CRF receptor family (CRF1 and CRF2), are found in the amygdala, site of origin of CRF-induced seizures, and may therefore mediate these ..
  79. pmc Altered maternal profiles in corticotropin-releasing factor receptor 1 deficient mice
    Stephen C Gammie
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    BMC Neurosci 8:17. 2007
    ..In this study, we examined the maternal profile of mice missing the CRF receptor 1 (CRFR1)...
  80. ncbi Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependence
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, 138 Yi Xue Yuan Road, Shanghai 200032, P R China
    Eur J Neurosci 12:4398-404. 2000
    ..These results suggest that the CRF receptor antagonists, particularly the CRF receptor subtype 1 antagonist, might be of some value in the treatment and prevention of drug dependence...
  81. ncbi Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications
    J R McCarthy
    Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
    Curr Pharm Des 5:289-315. 1999
    ..These fall into three distinct classes, encoded by three different genes and have been termed the CRF1 and CRF2 receptors (belonging to the superfamily of G-protein coupled receptors) and the CRF-binding protein...
  82. ncbi Effect of non-peptide corticotropin-releasing factor receptor type 1 antagonist on adrenocorticotropic hormone release and interleukin-1 receptors followed by stress
    H Pournajafi Nazarloo
    Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh cho, 783 8505, Nankoku, Japan
    Brain Res 902:119-26. 2001
    ..These data demonstrate differential effects of CRA 1000 in HPA axis following endotoxin and ether-laparotomy stress and complex interactions between CRF and IL-1 receptors during stress...
  83. ncbi Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellum
    James S King
    Department of Neuroscience, The Ohio State University, 333 W 10th Ave Columbus, Ohio 43210, USA
    J Neurocytol 32:305-16. 2003
    ....
  84. pmc Subcellular plasticity of the corticotropin-releasing factor receptor in dendrites of the mouse bed nucleus of the stria terminalis following chronic opiate exposure
    A Jaferi
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 407 East 61st Street, New York, NY 10065, USA
    Neuroscience 163:143-54. 2009
    ..The results have important implications for drug-associated adaptations in brain stress systems that may contribute to the motivation to continue drug use during dependence...
  85. ncbi Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders
    J Kehne
    Neurogen Corporation, 35 NE Industrial Road, Branford, CT 06405, USA
    Curr Drug Targets CNS Neurol Disord 1:467-93. 2002
    ....
  86. pmc Suppression of the MEK/ERK signaling pathway reverses depression-like behaviors of CRF2-deficient mice
    Cedomir Todorovic
    Specialized Neuroscience Research Project 2, John A Burns School of Medicine, University of Hawaii, 651 Ilalo St Honolulu, HI 96813, USA
    Neuropsychopharmacology 34:1416-26. 2009
    ..role in the proper functioning of the stress response system through its actions on its receptors, CRF receptor 1 (CRF1) and CRF receptor 2 (CRF2), located at multiple anatomical sites...
  87. ncbi 125I-Tyro-sauvagine: a novel high affinity radioligand for the pharmacological and biochemical study of human corticotropin-releasing factor 2 alpha receptors
    D E Grigoriadis
    Neurocrine Biosciences, Inc, San Diego, California 92121, USA
    Mol Pharmacol 50:679-86. 1996
    ..Corticotropin-releasing factor (CRF) receptors encoded by two distinct genes have recently been identified and termed CRF1 and CRF2...
  88. ncbi Corticotropin-releasing factor receptor type 1 mediates stress-induced relapse to cocaine-conditioned place preference in rats
    L Lu
    National Laboratory of Medical Neurobiology, Shanghai Medical University, Shanghai, People s Republic of China
    Eur J Pharmacol 415:203-8. 2001
    ..These findings suggest that CRF receptor subtype 1 antagonists might be of some value in the treatment and prevention of stress-induced relapse to drug dependence long after detoxification...
  89. ncbi Expression of urocortin and corticotropin-releasing factor receptor subtypes in the human heart
    Yuichiro Kimura
    Department of Pathology, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 87:340-6. 2002
    ..Endogenously produced Ucn may therefore exert its effects mostly through CRF-R2 in an autocrine and/or paracrine manner in the human heart...
  90. ncbi Evidence for an axonal localization of the type 2 corticotropin-releasing factor receptor during postnatal development of the mouse cerebellum
    K H Lee
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Exp Neurol 187:11-22. 2004
    ....
  91. ncbi Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior
    Victoria B Risbrough
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 24:6545-52. 2004
    The corticotropin-releasing factor (CRF) receptors (CRF1 and CRF2) are crucial mediators of physiological and behavioral responses to stress...
  92. ncbi Presynaptic localization of a truncated isoform of the type 2 corticotropin releasing factor receptor in the cerebellum
    J B Tian
    Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    Neuroscience 138:691-702. 2006
    ....
  93. ncbi Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice
    M V Schmidt
    Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 24:2291-8. 2006
    ..the current study we investigated the function of specific brain corticotropin-releasing hormone receptor type 1 (CRHR1) subpopulations in the control of the HPA axis during postnatal development under basal conditions as well as ..
  94. ncbi Mediation of burn-induced hypermetabolism by CRF receptor-2 activity
    William T Chance
    Burns Institute, Shriners Hospitals for Children, Cincinnati, OH 45267 0558, USA
    Life Sci 80:1064-72. 2007
    ..Increased neuronal activity at the CRF type 2 receptor (CRF R-2) appeared particularly involved in the expression of elevated resting energy expenditure (REE) following major ..
  95. ncbi Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    ..The VMH expresses both subtypes of CRF receptors, CRFR1 and CRFR2...
  96. ncbi Leptin effects on the expression of type-2 CRH receptor mRNA in the ventromedial hypothalamus in the rat
    M Nishiyama
    Second Department of Internal Medicine, Kochi Medical School, Kohasu, Japan
    J Neuroendocrinol 11:307-14. 1999
    ..Corticotropin-releasing hormone (CRH) is a potent anorectic neuropeptide, and its type-2 receptor (CRHR-2) in the ventromedial hypothalamus (VMH) appears to play an important role in the expression of this anorectic ..
  97. ncbi G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs
    Kazunori Kageyama
    Department of Endocrinology, Metabolism, and Infectious Diseases, Hirosaki University School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Endocrinology 147:441-50. 2006
    Hypothalamic CRF stimulates synthesis and secretion of ACTH via CRF receptor type 1 (CRFR1) in the anterior pituitary gland. After agonist-activated stimulation of receptor signaling, CRFR1 is down-regulated and desensitized...
  98. ncbi Urocortin in the synovial tissue of patients with rheumatoid arthritis
    M Uzuki
    The First Department of Pathology, Iwate Medical University, School of Medicine, 19 1 Uchimaru, Morioka, Iwate 020 8505, Japan
    Clin Sci (Lond) 100:577-89. 2001
    ..Urocortin was actively synthesized in the synovium of RA patients. The present study suggests that urocortin may play an important role as an autocrine and/or paracrine regulator of synovial inflammation in RA...
  99. ncbi Glucocorticoids regulate the expression of the mouse urocortin II gene: a putative connection between the corticotropin-releasing factor receptor pathways
    Alon Chen
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Endocrinol 17:1622-39. 2003
    ..In light of our present data and the current literature, we propose a putative link between the CRF receptor 1 and CRF receptor 2 pathways...
  100. ncbi Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
    G W Smith
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Neuron 20:1093-102. 1998
    ..Two biochemically and pharmacologically distinct CRF receptor subtypes (CRFR1 and CRFR2) have been described...
  101. ncbi Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1
    A Contarino
    The Scripps Research Institute, Department of Neuropharmacology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 835:1-9. 1999
    ..Two distinct CRF receptor subtypes, CRFR1 and CRFR2, are thought to mediate CRF actions in the CNS...

Research Grants63

  1. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..Brain corticotropin-releasing factor (CRF) and CRF receptor 1 (CRF1) play an important role in the colonic motor, anxiogenic and endocrine responses to stress, while activation of ..
  2. Richard L Hauger; Fiscal Year: 2016
    ..We will also direct our research toward identifying novel molecular targets for drug discovery that will lead to new PTSD treatments with higher efficacy and therapeutic index. ..
  3. Marc R Montminy; Fiscal Year: 2014
    ..We have chemically and biologically characterized multiple components of this system including two receptor genes (CRFR1 and CRFR2), a CRF binding protein and three urocortins (Ucn 1, 2 and 3)...
  4. John R Mantsch; Fiscal Year: 2014
    ..The ability of a rat model of excessive drug use to enhance CRF regulation of drug-seeking behavior in a manner that depends on secretion of glucocorticoid hormones will be tested. ..
  5. Sex differences in the corticotropin-releasing factor receptor
    DEBRA WAXLER BANGASSER; Fiscal Year: 2010
    ..Importantly, because CRF antagonists are being developed to treat depression and anxiety disorders, sex differences in the CRFr could impact the efficacy of these compounds in women. ..
  6. Victoria B Risbrough; Fiscal Year: 2014
    ..coordinates many behavioral and neuroendocrine responses to stress via activation of two known receptor subtypes, CRF1 and CRF2...
  7. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2012
    ..The goal of my current research is to identify sex differences in a receptor for CRF (CRF1 subtype) that may account for sex differences in stress responsivity...
  8. Regulation and Function of Urocortins and their Receptors
    Aditi Bhargava; Fiscal Year: 2013
    ..corticotropin-releasing factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
  9. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..to addictive behavior - acquisition, binge, reinstatement - to determine the role for CRF receptor subtypes (CRFR1 or CRFR2)and sex in these effects...
  10. Mechanisms of Postoperative Ileus
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..made in our laboratories including key molecular probes to assess gene expression of rodent CRF ligands and CRF1 and CRF2 receptors and novel receptor variants that we have cloned, the use of laser captured microdissected brain ..
  11. Debra A Bangasser; Fiscal Year: 2014
    ..The goal of my current research is to identify sex differences in a receptor for CRF (CRF1 subtype) that may account for sex differences in stress responsivity...
  12. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..that: 1) blockade of BDNF binding to TrkB receptor attenuates BDNF-inhibited feeding;2) blockade of CRH receptor (CRHR) signaling attenuates BDNF-inhibited feeding;and 3) chronic (14 d) injection of BDNF reduces feeding and body ..
  13. Tracy L Bale; Fiscal Year: 2015
    ..which has promoted the pharmaceutical pursuit of therapeutic targets including antagonists of the CRF receptor-1 (CRFR1) that would blunt this response...
  14. Neoropeptide Basis of Social Loss and Depression
    Larry J Young; Fiscal Year: 2012
    ..appears to be mediated by the corticotropin-releasing factor (CRF) system, as blocking either of the CRF receptors (CRF1 or CRF2) prevents the onset of depressive-like behavior following social loss...
  15. Neurochemical Manipulation of Withdrawal-Induced Drinking
    DEBORAH ANN FINN; Fiscal Year: 2012
    ..that systemic administration of baclofen (GABAB receptor agonist), MPEP (mGluR5 antagonist), and NBI 27914 (CRF1 receptor antagonist) significantly decreased the expression of WID...
  16. CRF System and Methamphetamine Extinction
    Andrey E Ryabinin; Fiscal Year: 2010
    ..The CRF peptide system is complex, consisting of two main types of receptors, CRF1 and CRF2, and four endogenous ligands, CRF, urocortin 1 (Ucn1), urocortin 2 (Ucn2) and urocortin 3 (Ucn3)...
  17. Marisa Roberto; Fiscal Year: 2016
    ..rationale: 1) Acute ethanol markedly enhances GABAergic neurotransmission in CeA through the activation of CRF1 receptors...
  18. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    ..of CRF mechanisms across the brain suggests that two dichotomous anatomical CRF systems, mediated by specific CRF1 versus CRF2a receptor subtypes, modulate unique facets of the stress response...
  19. CRF RECEPTOR ANTAGONISTS IN NEUROPROTECTION
    Alan Foster; Fiscal Year: 2001
    ..The effects of CRF are mediated by two receptor sub-types, CRF1 and CRF2...
  20. Corticotropin Releasing Factor Receptor Function in CNS
    Robert Petroski; Fiscal Year: 2002
    ..Two related genes encode the CRF1 and CRF2 receptor subtypes, which exhibit distinct expression patterns in the brain...
  21. NOVEL CRF RECEPTOR
    Dimitri Grigoriadis; Fiscal Year: 1999
    ..Two CRF receptor subtypes (CRF1 and CRF2 receptors) which share approx...
  22. Novel Drug Discovery Tools for Depression and Anxiety
    STEVEN NANDA; Fiscal Year: 2003
    ..transfected with constructs containing the luciferase reporter gene under control of the human CRF receptor 1 (CRF1) promoter. Studies will characterize the basal levels of expression from the stably transfected cultures...
  23. Novel CRF antagonists for inflammation and pain
    MARK LINDNER; Fiscal Year: 2002
    ..Orally active forms of a small molecule CRF receptor would provide a novel therapeutic strategy for indications of acute and chronic inflammation and inflamatory pain. ..
  24. Organization /Function of Extended Amygdala CRF Systems
    Sheila Reynolds; Fiscal Year: 2005
    ..Although actions of CRF are thought to be mediated by at least two systems (through CRF1 versus CRF2 receptor subtypes) with distinct distribution patterns throughout the brain, the extended amygdala/..
  25. Phosphorylation/desensitization/internalization of CRFRI
    IMAN ASSIL; Fiscal Year: 2004
    ..Understanding the molecular basis of associated with CRF receptors desensitization, particularly type 1 (CRFR1), will help in understanding the various diseases associated with persistent activation of the HPA axis...
  26. Brain mast cells and Chronic Fatigue Syndrome
    Theoharis C Theoharides; Fiscal Year: 2013
    ..hormone (CRH)-positive neurons and CRH is secreted under stress and we showed that CRH activates mast cells through CRHR-1 leading to release of vascular endothelial growth factor (VEGF), increased vascular permeability and blood-brain-..
  27. Tallie Z Baram; Fiscal Year: 2014
    ..cognitive function and LTP, together with dendritic atrophy, we found that post hoc blocking of the receptor (CRFR1) of the stress-activated neuropeptide, corticotropin releasing hormone (CRH) immediately after the ES period, ..
  28. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ..In order to test the hypothesis that BNST CGRP enhances BNST CRF neuron activation to increase CRFr1 receptor signaling in stress-related target structures, rats will be treated with a systemic CRFr1 antagonist (..
  29. Donald G Rainnie; Fiscal Year: 2016
    ..Significantly, pilot data suggests that the response to RRS can be blocked by prior administration of a CRF1 receptor antagonist, or a histone-deacetylase inhibitor, which alters gene transcription...
  30. Pietro Cottone; Fiscal Year: 2015
    ..and molecular approach to elucidate: i) the brain sites important for the pharmacological effects of CRF1 receptor antagonists on the consummatory, emotional and motivational components of compulsive eating;ii) the ..
  31. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..It is the aim of this project to discover &develop novel therapeutic agents with unique mechanisms of action for more effective treatment of tobacco addiction and relapse. ..
  32. Neural mechanisms of heightened fear during glucocorticoid excess
    Jack D Shepard; Fiscal Year: 2010
    ..administration into the amygdala increases CRF mRNA in this structure and systemic administration of the selective CRF1 receptor antagonist antalarmin abolishes heightened fear when glucocorticoids are elevated in the amygdala...
  33. Stress and Drug Use Vulnerability in Rural African Americans
    Ezemenari M Obasi; Fiscal Year: 2010
    ..Measured variables will include genotype (CRH and CRHR1), hormones (cortisol and DHEA), autonomic measures (galvanic skin conductance and heart rate variability), chronic ..
  34. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    Corticotropin-releasing factor (CRF) and urocortin (Ucn) 1 interact with two Gs coupled CRF1 and CRF2 receptors. Recently, new CRF-related peptides, Ucn 2 and Ucn 3 were discovered as selective CRF2 agonists...
  35. Stress and CRF Signaling in Alzheimer?s Disease Pathogenesis
    Paul E Sawchenko; Fiscal Year: 2012
    ..find the response is abolished by disruption of signaling via the type 1 corticotropin-releasing factor receptor (CRFR1) and exaggerated in CRFR2-deficient mice...
  36. MILLION MULUGETA; Fiscal Year: 2016
    ..and corticotropin-releasing factor (CRF) exert a profound effect on colon secreto-motor function, primarily through CRF1 receptors. The physiological role of CRF2 in the colonic response to stress is unknown...
  37. Nicotine withdrawal and relapse: role of neuroadaptations in brain stress systems
    ADRIAAN WILLEM BRUIJNZEEL; Fiscal Year: 2012
    ..Specific Aim 1 will explore the role of CRF1, CRF2, a2-adrenergic, and [unreadable]1/2- adrenergic receptors in the CeA and BNST in the dysphoria associated ..
  38. Kerry J Ressler; Fiscal Year: 2016
    ..Genetic risk factors include polymorphisms of the ADCYAP1R1, FKBP5, DAT, BDNF, COMT, CRFR1, 5HTTLPR, RGS2, GABA2 and 5HT3R genes, novel genetic and epigenetic risk factors and most importantly, the primary ..
  39. Charles B Nemeroff; Fiscal Year: 2016
    ..Genetic risk factors include polymorphisms of the ADCYAP1R1, FKBP5, DAT, BDNF, COMT, CRFR1, 5HTTLPR, RGS2, GABA2 and 5HT3R genes, novel genetic and epigenetic risk factors and most importantly, the primary ..
  40. Functional Properties of Protein Segments in Receptors and Transporters
    Harel Weinstein; Fiscal Year: 2013
    ..A broadening of the scope to a class C GPCR (CRF1) is also planned...
  41. Marisa Roberto; Fiscal Year: 2016
    ..Particularly, CRF type 1 receptor (CRF1) antagonists block the anxiogenic effects and the increase in ethanol self-administration produced by stressors and ..
  42. Howard C Becker; Fiscal Year: 2016
    ..will build and expand on our current work by utilizing our CIE model of dependence to examine the role of CRF and CRF1 receptor activity in brain regions within cortical-limbic-HPA circuitry (brain structures and pathways integral to ..
  43. James L Abelson; Fiscal Year: 2016
    ..HPA feedback sensitivity, but this effect is only seen in subjects with a particular variant of an HPA gene (CRHR1) and can remain undetected if the genetic effect is ignored...
  44. Synaptic and peptidergic neuroadaptations associated with alcohol dependence
    Marisa Roberto; Fiscal Year: 2012
    ..rats by increasing GABA release, and that this ethanol effect involves intermediary substrates such as presynaptic CRF1 receptors...
  45. ANNE NICOLE BANDUCCI; Fiscal Year: 2014
    ..g. CRHR1, GCCR, DAT, COMT, and GABRA2) on DT (assessed via the Behavioral Indicator of Resiliency to Distress) and ..
  46. Volker Neugebauer; Fiscal Year: 2016
    ..CRF) signaling in the amygdala because CRF is associated with 5-HT2CR- mediated negative affective states and CRF1 receptors mediate amygdala plasticity in inflammatory pain...
  47. CFR signaling in stress- and dependence- induced ethanol consumption
    EMILY GEYER LOWERY; Fiscal Year: 2010
    ..ethanol dependent animals, as well as stress-induced increases in ethanol consumption in nondependent animals, via CRF1 and CRF2 receptor signaling...
  48. CRF Modulation of NMDA Currents and Behavior in the VTA
    Matthijs Verhage; Fiscal Year: 2013
    ..recordings in the VTA, specific aim 1 will elucidate in detail: a) the intracellular pathway responsible for the CRFR1-dependent increase in firing rate, and b) the intracellular pathways responsible for the CRF-R2-dependent increase ..
  49. PROJECT INFORM - INFORMATION FOR RURAL MEDICINE PHASE 2
    MARY PUNG; Fiscal Year: 2001
    ..Center (AHEC), Henderson Library of Georgia Southern University (GSU), the Center for Rural Health and Research (CRHR) at GSU, Carl Vinson Veterans Administration Medical Center Library and twelve hospitals in southeast Georgia...
  50. Cholinergic and GABAergic Mechanisms in the Septohippocampal Pathway
    Meenakshi Alreja; Fiscal Year: 2010
    ..that give rise to the mnemonically important septohippocampal pathway receive CRF innervation, are endowed with CRF1 receptors and in preliminary electrophysiological studies were activated by CRF and cAMP analogs...
  51. Stress, Rearing, and Ethanol Reinforcement in Monkeys
    James Woods; Fiscal Year: 2005
    ..mCPP, the benzodiazepine receptor inverse agonist beta-carboline-3-carboxylic acid ethyl ester, and the putative CRHR1 receptor agonist EG1...
  52. Bimolecular interactions of CRF ligands and receptors
    Abdul Abou Samra; Fiscal Year: 2006
    ..we described an oxidation-resistant radio labeled sauvagine analog (YQLS), that can be covalently cross linked to CRFR1 and CRFR2, using a chemical cross linking agent that cross links lysine residues...
  53. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..The affinity and density of cerebral cortical corticotrophin releasing factor1 (CRF1) receptors will also be quantified. 3...
  54. Altered hypothalamic-pituitary-adrenal function in the Fragile X mouse
    JULIE LAUTERBORN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Development of 11C-labeled probes for imaging CRF
    J S Dileep Kumar; Fiscal Year: 2004
    The overall objective of this project is to develop PET imaging probes to quantify in vivo levels of CRF1 receptor binding in living subjects from mice to humans...
  56. MicroRNA Regulation of Serotonin Receptor 1B and its Relation to Behavior
    Kevin Jensen; Fiscal Year: 2009
    ..sites that have been identified in-silico in other candidate genes relevant to alcohol use disorders (including CRHR1, CNR1, DRD2, COMT, HTR2A, HTR2C, OPRM1, PDYN, GABRA6, MANEA) also modify microRNA regulation...
  57. Vulnerability Factors and Drinking in Adulthood
    Michael Windle; Fiscal Year: 2009
    ..The DNA from the 782 adults will be used to conduct candidate gene analyses for GABRA2, GABRA1, CHRM2, CRHR1, CNR1, 5HTTLPR, and DRD2 for alcohol and depression phenotypes...
  58. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..distribution of CRF receptors and the non-selectivity of available peptide ligands, the relative roles of CRF1 and CRF2_ receptors in the regulation of feeding have remained elusive...
  59. Role of CRF in ethanol negative reinforcement
    CINDY REITER; Fiscal Year: 2006
    ..The experiments in this proposal are designed to study the role of CRF1 and CRF2 receptors in specific brain regions in mediating the enhanced drinking associated with ethanol withdrawal...
  60. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  61. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  62. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  63. Effect of CRF1 Receptor Genotype and Stress on Anxiety and Alcohol Endophenotypes
    Lisa Conti; Fiscal Year: 2008
    ..a polymorphism that has not previously been described, in the conserved region upstream of the CRF1 receptor gene (CRHR1) on chromosome 10. Three Specific Aims will be addressed in this exploratory project. Specific Aim 1...