Genomes and Genes
Gene Symbol: CRH
Description: corticotropin releasing hormone
Alias: CRF, CRH1, corticotropin-releasing factor
Publications419 found, 100 shown here
- Distribution and quantification of corticotropin-releasing hormone (CRH) in the brain of the teleost fish Oreochromis mossambicus (tilapia)Peter P L M Pepels
Department of Animal Physiology, Faculty of Science, University of Nijmegen, 6525 ED Nijmegen, The Netherlands
J Comp Neurol 453:247-68. 2002The recent characterization of the corticotropin-releasing hormone (CRH) prehormone of the fish tilapia (Oreochromis mossambicus) showed that more variation exists between vertebrate CRH amino acid sequences than recognized before...
- Modulation of corticotropin-releasing hormone receptor type 2 mRNA expression by CRH deficiency or stress in the mouse heartHossein Pournajafi Nazarloo
Second Department of Internal Medicine, Kochi Medical School, Kohasu, Okoh cho, Nankoku 783 8505, Japan
Regul Pept 115:131-8. 2003The actions of corticotropin-releasing hormone (CRH) and the related peptides are coordinated by two receptors, CRH receptor type 1 (CRH-R1) and CRH receptor type 2 (CRH-R2)...
- Corticotropin-releasing hormone in the teleost stress response: rapid appearance of the peptide in plasma of tilapia (Oreochromis mossambicus)P P L M Pepels
Department of Animal Physiology, Faculty of Sciences, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
J Endocrinol 180:425-38. 2004High concentrations (up to 600 pg/ml) of corticotropin-releasing hormone (CRH) were detected in plasma of the teleost fish Oreochromis mossambicus (tilapia) when screening peripheral tissues of tilapia exposed to stress...
- Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblastsLu Gao
Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
Endocrinology 153:1464-71. 2012..Regulatory mechanisms of GLUT in placenta have not been elucidated. Placental CRH has been implicated to play a key role in the control of fetal growth and development...
- Corticotropin-releasing hormone induces keratinocyte differentiation in the adult human epidermisBlazej Zbytek
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Cell Physiol 203:118-26. 2005Previously we documented that human epidermis exclusively expresses corticotropin releasing hormone receptor 1 (CRH-R1)...
- Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamusRie Yamamoto
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Chiba 260 8670, Japan
J Biol Chem 286:21458-65. 2011..In the hypothalamus, mRNA levels of anorexigenic neuropeptide corticotropin-releasing hormone (Crh) were lower in Agtr1a(-/-) mice than in Agtr1a(+/+) mice both on an ad libitum and pair-fed diet...
- Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitisMichela Torricelli
Department of Pediatrics, Obstetrics, and Reproductive Medicine, University of Siena, 53100, Siena, Italy
J Clin Endocrinol Metab 96:534-40. 2011The pathogenesis of preterm delivery (PTD) is not clear, although inflammation/infection play a major role. Corticotropin releasing-hormone (CRH) and Urocortins (Ucns) are involved in the pathophysiology of PTD.
- Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1P Timpl
Max Planck Institute of Psychiatry, Munich, Germany
Nat Genet 19:162-6. 1998Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal ..
- A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranesD K Grammatopoulos
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
Mol Endocrinol 13:2189-202. 1999b>CRH exerts its actions via activation of specific G protein-coupled receptors, which exist in two types, CRH-R1 and CRH-R2, and arise from different genes with multiple spliced variants...
- A placental clock controlling the length of human pregnancyM McLean
Maternal Health Research Centre, John Hunter Hospital, Newcastle, NSW, Australia
Nat Med 1:460-3. 1995..study of 485 pregnant women we have demonstrated that placental secretion of corticotropin-releasing hormone (CRH) is a marker of this process and that measurement of the maternal plasma CRH concentration as early as 16-20 weeks ..
- CRH functions as a growth factor/cytokine in the skinA Slominski
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Cell Physiol 206:780-91. 2006We tested the effect of CRH and related peptides in a large panel of human skin cells for growth factor/cytokine activities...
- Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at termB Wetzka
Dept of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
Exp Clin Endocrinol Diabetes 111:154-61. 2003Recent research suggests a significant role for placental corticotropin-releasing hormone (CRH) in controlling human parturition...
- The expression of corticotropin-releasing hormone in melanomaHirofumi Sato
Department of Dermatology, Kobe University School of Medicine, Japan
Pigment Cell Res 15:98-103. 2002..whether the high expression of POMC derives from increased expression of corticotropin-releasing hormone (CRH) and the possible role of CRH as a melanoma growth factor...
- Increased connexin 43 expression as a potential mediator of the neuroprotective activity of the corticotropin-releasing hormoneRegina Hanstein
Institute of Pathobiochemistry, University Medical Center, Johannes Gutenberg University, 55099 Mainz, Germany
Mol Endocrinol 23:1479-93. 2009b>CRH is a major central stress mediator, but also a potent neuroprotective effector. The mechanisms by which CRH mediates its neuroprotective actions are largely unknown...
- Placental stress factors and maternal-fetal adaptive response: the corticotropin-releasing factor familyPasquale Florio
Chair of Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
Endocrine 19:91-102. 2002..Among these factors, corticotropin-releasing factor (CRF) has been one of the more investigated in the last decade...
- Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone geneRomina Combi
Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
Ann Neurol 58:899-904. 2005..In particular, on chromosome 8, corticotropin-releasing hormone gene (CRH) appears to be a good candidate. We therefore searched for CRH mutations in the proband...
- Estrogen receptor-alpha and -beta regulate the human corticotropin-releasing hormone gene through similar pathwaysXiao Ning Chen
Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
Brain Res 1223:1-10. 2008Corticotropin-releasing hormone (CRH) plays a central role in controlling stress response. In this study, we aimed to identify the regulatory effect of estrogen receptor (ER) on CRH and the underlying mechanism...
- Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cellsEleni Aggelidou
Sir Quinton Hazell Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, United Kingdom
Proc Natl Acad Sci U S A 99:3300-5. 2002The biological actions of corticotropin-releasing hormone (CRH) in the human myometrium during pregnancy and labor are unknown...
- mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCRB Sehringer
Department of Obstetrics and Gynaecology, Endocrinology Laboratory, University of Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
J Mol Endocrinol 32:339-48. 2004Increasing maternal plasma levels of corticotrophin-releasing hormone (CRH) during the last weeks of pregnancy suggest that this stress hormone plays an important role in the control of human parturition...
- The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern SwedenStephan Claes
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Belgium
Biol Psychiatry 54:867-72. 2003..Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression...
- Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological researchX J Zhao
Department of Internal Medicine I, University of Leipzig, Germany
Horm Metab Res 29:373-8. 1997Corticotropin-releasing hormone-binding protein (CRH-BP), predominately produced by the liver, is a glycoprotein with a molecular weight of 37 kDa...
- Pituitary gland: neuropeptides, neurotransmitters and growth factorsJ I Koenig
Neurology Service, Massachusetts General Hospital, Boston
Toxicol Pathol 17:256-65. 1989..These effects appear to be mediated by changes in the secretion of the corticotropin-releasing hormone (CRH) and vasopressin into the hypophyseal portal circulation...
- Involvement of stress in the sleep rebound mechanism induced by sleep deprivation in the rat: use of alpha-helical CRH (9-41)M M Gonzalez
Departement de Medecine Experimentale, INSERM U480, Faculte de Medecine, Universite Claude Bernard, Lyon, France
Behav Pharmacol 9:655-62. 1998A previous study demonstrated the efficacy of the corticotropin-releasing hormone (CRH) receptor antagonist, alpha-helical CRH (9-41), in blocking the paradoxical sleep increase induced by stress...
- Expression of the corticotropin-releasing hormone (CRH) gene in human placenta and amniotic membraneE Okamoto
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
Horm Metab Res 22:394-7. 1990Immunoreactive corticotropin-releasing hormone (IR-CRH) in maternal plasma increases progressively during pregnancy and decreases rapidly after delivery, suggesting that IR-CRH is produced in the placenta...
- Neuropeptides and human sleepA Steiger
Max Planck Institute of Psychiatry, Department of Psychiatry, Munich, Germany
Sleep 20:1038-52. 1997..the balance between the neuropeptides growth hormone-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) plays a key role in normal and pathological sleep regulation...
- Procaine and lidocaine stimulate corticotropin-releasing hormone secretion by explanted rat hypothalami through a sodium conductance-independent mechanismA E Calogero
Developmental Endocrinology Branch, National Institute of Child Health and Human Developmental, National Institute of Mental Health, Bethesda, Maryland
Horm Metab Res 22:25-8. 1990We have previously shown that procaine and lidocaine stimulate corticotropin-releasing hormone (CRH) secretion by explanted rat hypothalami...
- [Studies on the influence of releasing hormones TRH and CRH on respiratory regulation]M Nink
III. Medizinische Klinik und Poliklinik, Innere Medizin,
Pneumologie 45:246-8. 1991Patterns of neuroanatomical distribution of Thyrotropin-releasing hormone (TRH) and Corticotropin-releasing hormone (CRH) and of their receptors in brain areas of humans and of animals suppose a regulating function of both peptides on ..
- Brain evoked responses, a bioassay for central actions of adrenocorticotropin (ACTH 1-39) and corticotropin releasing hormone (CRH) in humansJ Born
, , Germany
Horm Metab Res 23:126-30. 1991..are part of a series of studies which have been conducted to demonstrate the afferent influences of ACTH and CRH on brain activity by recording of auditory event-related brain potentials (ERPs) in healthy human subjects...
- Immunoreactive corticotropin-releasing hormone, adrenocorticotropin and cortisol in human plasma during pregnancy and delivery and postpartumE Okamoto
Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
Horm Metab Res 21:566-72. 1989..adrenal axis was examined, by measuring the levels of immunoreactive (IR) corticotropin-releasing hormone (CRH), adrenocorticotropin (ACTH) and cortisol (F) in human plasma during normal pregnancy and after delivery with or ..
- The stress-, but not corticotropin-releasing hormone-induced activation of the pituitary-adrenal axis in man is blocked by alprazolamT Rohrer
III. Medizinische Klinik, Innere Medizin-Endokrinologie, , Germany
Horm Metab Res 26:200-6. 1994A number of experimental studies clearly suggest that benzodiazepines attenuate the corticotropin-releasing hormone (CRH) secretion possibly through inhibitory GABAergic neurons...
- Does estradiol treatment normalize the hypothalamic-pituitary-adrenal axis in streptozotocin-induced ovariectomized diabetic female rats?K E Elkind-Hirsch
Department of Medicine, Methodist Hospital, Houston, Texas
Horm Metab Res 23:481-5. 1991..It was the purpose of this study to evaluate basal and corticotropin releasing hormone (CRH)-stimulated CS secretion in ovariectomized (OVX) control (C) and streptozotocin-induced diabetic (D) rats given ..
- Interleukin-1 potentiates basal and AVP-stimulated ACTH secretion in vitro--the role of CRH pre-incubationW J Inder
Department of Endocrinology, Christchurch Hospital, New Zealand
Horm Metab Res 32:350-4. 2000..IL-1) is known to activate the hypothalamic pituitary adrenal axis, primarily via corticotropin releasing hormone (CRH)...
- CRH and lysine-vasopressin stimulation tests in the diagnosis of hypoadrenalism secondary to hypothalamic or pituitary disordersL Cantalamessa
Semeiotica Medica I, , Ospedale Maggiore, Italy
Horm Metab Res 22:389-93. 1990Ten patients with secondary hypoadrenalism have been tested with corticotropin releasing hormone (CRH) and lysine-vasopressin (LVP)...
- Antisense oligodeoxynucleotides for in vivo targeting of corticotropin-releasing hormone mRNA: comparison of phosphorothioate and 3'-inverted probe performanceT Skutella
Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany
Horm Metab Res 26:460-4. 1994..An attempt was made to establish an animal model of reduced corticotropin-releasing hormone (CRH) activity, using antisense DNA corresponding to the start coding region of rat CRH mRNA with either 3'-3' inverted ..
- Role of prostaglandin E2 (PGE2) on the corticotropin-releasing hormone (CRH)-induced ACTH release in healthy menS Zacharieva
Institute of Endocrinology and Gerontology, Medical Academy, Sofia, Bulgaria
Horm Metab Res 24:336-8. 1992The effect of PGE2 on ACTH and cortisol responses to CRH was studied in 6 healthy men who received CRH i.v. during either saline or PGE2 infusions which were started 60 min. before testing...
- Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei--potential implication for arousal and attentionM Sauvage
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804, Munich, Germany
Neuroscience 104:643-52. 2001Corticotropin-releasing hormone (CRH) interacts with noradrenergic, dopaminergic and cholinergic systems of the brain, and these interactions are thought to be of relevance for the stress response, anxiety-related behavior, and cognitive ..
- Maternal and fetal hypothalamic-pituitary-adrenal axes during pregnancy and postpartumGeorge Mastorakos
2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, Aretaieion Hospital, Athens, Greece
Ann N Y Acad Sci 997:136-49. 2003The principal modulators of the hypothalamic-pituitary-adrenal (HPA) axis are corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP). Corticotropin-releasing hormone is not exclusively produced in the hypothalamus...
- [Expression and roles of corticotropin-releasing hormone, cortisol and dehydroepiandrosterone sulfate in preterm labour]Yi ling Ding
Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, China
Zhonghua Fu Chan Ke Za Zhi 42:239-43. 2007To investigate the effect of corticotropin-releasing hormone (CRH), cortisol and dehydroepiandrosterone sulfate in pathogenesis of preterm labor.
- Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell lineJ Kasckow
Cincinnati VAMC, Psychiatry Service 116A, and School of Medicine, Department of Psychiatry, and Neurosciences Program, University of Cincinnati, OH 45267 0559, USA
J Neuroendocrinol 15:521-9. 2003..One cell line was chosen (IVB) which exhibited CRH-like immunoreactivity (CRH-LI) and expressed CRH, VP and CRH1 receptor RNA via the reverse transcriptase-polymerase chain reaction...
- Antipsychotic drugs inhibit the human corticotropin-releasing-hormone gene promoter activity in neuro-2A cells-an involvement of protein kinasesAgnieszka Basta-Kaim
Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Neuropsychopharmacology 31:853-65. 2006..However, molecular mechanism of antipsychotic drug action on the corticotropin-releasing hormone (CRH) gene activity has not been investigated so far...
- Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonistsT Z Baram
Department of Anatomy Neurobiology, University of California at Irvine, CA 92697 4475, USA
Dev Neurosci 21:281-9. 1999..involving suppression of the age-specific endogenous convulsant neuropeptide corticotropin-releasing hormone (CRH)...
- Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammationShin Fukudo
Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2 1 Seiryo, Aoba, Sendai, 980 8575, Japan
J Gastroenterol 42:48-51. 2007..Plasma ACTH and serum cortisol were generally not suppressed by alphahCRH. Last, administration of CRH1-receptor (CRH-R1) specific antagonist blocked colorectal distention-induced sensitization of the visceral ..
- Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory painShaaban A Mousa
Klinik fur Anaesthesiologie und operative Intensivmedizin, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany
Pain 106:297-307. 2003In painful inflammation, exogenous as well as endogenous corticotropin-releasing hormone (CRH) can release opioid peptides (mainly beta-endorphin) from various types of immune cells and produce antinociception by activating opioid ..
- Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brainKristen L Brunson
Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
Exp Neurol 176:75-86. 2002In addition to regulating the neuroendocrine stress response, corticotropin-releasing hormone (CRH) has been implicated in both normal and pathological behavioral and cognitive responses to stress...
- Expression of corticotropin-releasing hormone receptor type 1 and type 2 in human pregnant myometriumDan Jin
Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, PR China
Reprod Sci 14:568-77. 2007It has been suggested that corticotropin-releasing hormone (CRH) receptors CRH-R1 and CRH-R2 might be involved in the modulation of uterine activity during pregnancy...
- Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in miceChristoph P N Romanowski
Max Planck Institute of Psychiatry, Munich, Germany
Sleep 33:427-36. 2010Corticotropin-releasing hormone (CRH) is the major activator of the hypothalamic-pituitary-adrenocortical (HPA) system and orchestrates the neuroendocrine, autonomous as well as behavioral responses to stress...
- Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microgliaWei Wang
Department of Pediatrics, Kingston General Hospital, Ontario, Canada
J Neurochem 80:287-94. 2002Corticotropin-releasing hormone (CRH), known as a key regulator of the hypothalamic-pituitary-adrenal axis response to stress, elicits its biological effects by binding to two membrane receptors (CRH-R1 and CRH-R2)...
- The stress system in the human brain in depression and neurodegenerationDick F Swaab
Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
Ageing Res Rev 4:141-94. 2005Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the hypothalamic-pituitary-adrenal (HPA)-axis, i.e., the final common pathway in the stress response...
- Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigationPathik D Wadhwa
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 4260, USA
Am J Obstet Gynecol 191:1063-9. 2004Recent advances in the physiology of human pregnancy have implicated placental corticotropin-releasing hormone (CRH) as one of the primary endocrine mediators of parturition and possibly also of fetal development...
- Levels of maternal serum corticotropin-releasing hormone (CRH) at midpregnancy in relation to maternal characteristicsYumin Chen
Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA
Psychoneuroendocrinology 35:820-32. 2010Corticotropin-releasing hormone (CRH) in maternal blood originates primarily from gestational tissues and elevated levels in midpregnancy have been linked to adverse pregnancy outcomes...
- Synaptic physiology of central CRH systemJoel P Gallagher
University of Texas Medical Branch, Department of Pharmacology and Toxicology Galveston, TX 77555 1031 USA
Eur J Pharmacol 583:215-25. 2008Corticotropin-Releasing Hormone (CRH) or Corticotropin-Releasing Factor (CRF) and its family of related naturally occurring endogenous peptides and receptors are becoming recognized for their actions within central (CNS) and peripheral (..
- Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's statesJ A Yanovski
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
JAMA 269:2232-8. 1993..Both dexamethasone suppression and corticotropin-releasing hormone (CRH) stimulation tests have been used individually to distinguish these conditions, but neither approach has achieved a ..
- The stress system in depression and neurodegeneration: focus on the human hypothalamusA M Bao
Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
Brain Res Rev 57:531-53. 2008..Activity of the corticotropin-releasing hormone (CRH) neurons in the hypothalamic paraventricular nucleus (PVN) forms the basis of the activity of the HPA-axis...
- Mouse strain differences in the effects of corticotropin releasing hormone (CRH) on sleep and wakefulnessL D Sanford
Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, USA
Brain Res 1190:94-104. 2008Corticotropin releasing hormone (CRH) plays a major role in central nervous system responses to stressors and has been implicated in stress-induced alterations in sleep...
- Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasisChunlei Zhou
Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, PR China
Med Hypotheses 73:513-5. 2009..Corticotrophin-releasing hormone (CRH) is a central component of the hypothalamic-pituitary-adrenal (HPA) axis and is an important coordinator of the ..
- D-amino acid-substituted analogs of corticotropin-releasing hormone (CRH) and urocortin with selective agonist activity at CRH1 and CRH2beta receptorsE T Wei
School of Public Health, University of California, Berkeley 94720, USA
Peptides 19:1183-90. 1998..hormone (CRH)-related peptides and several analogs were examined in cells transfected with either CRH1 or CRH2beta receptors, in suppression of heat-induced rat paw edema in pentobarbital-anesthetised animals and in ..
- Differential release of corticotropin-releasing hormone (CRH) in the amygdala during different types of stressorsGregory A Hand
Department of Exercise Science, University of South Carolina, 1300 Wheat St, Columbia, SC 29208, USA
Brain Res 949:122-30. 2002..exist between the effects of acute treadmill running and restraint stress on corticotropin-releasing hormone (CRH) release within the amygdala of rats...
- Central activation of thermogenesis by prostaglandins: dependence on CRFN J Rothwell
Department of Physiological Sciences, University of Manchester, United Kingdom
Horm Metab Res 22:616-8. 1990..The effects of combined injection of maximal doses of CRF and PGE2 were additive, whereas PGF2 alpha and CRF were not...
- Oreochromis mossambicus (tilapia) corticotropin-releasing hormone: cDNA sequence and bioactivityF H van Enckevort
Department of Animal Physiology, Faculty of Science, University of Nijmegen, Toernooiveld, Nijmegen, The Netherlands
J Neuroendocrinol 12:177-86. 2000Although hypothalamic corticotropin-releasing hormone (CRH) is involved in the stress response in all vertebrate groups, only a limited number of studies on this neuroendocrine peptide deals with non-mammalian neuroendocrine systems...
- CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaquesChristina S Barr
Laboratory of Clinical Studies, Primate Section, National Institute on Alcohol Abuse Alcoholism, Division of Intramural Clinical and Biological Research, TR 112, PO Box 529, Poolesville, MD 20837, USA
Arch Gen Psychiatry 65:934-44. 2008..in stress reactivity, exploration, and response to novelty have been attributed to differences in corticotropin-releasing hormone (CRH) system function. As such, CRH gene variation may influence risk for alcohol use and dependence.
- Immunoautoradiographic and in situ hybridization analysis of corticotropin-releasing hormone biosynthesis in the hypothalamic paraventricular nucleusJ P Herman
Department of Anatomy and Neurobiology, University of Kentucky School of Medicine, Lexington 40536 0084, USA
J Chem Neuroanat 11:49-56. 1996Corticotropin-releasing hormone (CRH) gene transcription and mRNA expression are keyed to stimuli activating the pituitary-adrenocortical axis, suggesting a connection between neuronal activation and synthesis of active peptide...
- Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glandsK Krause
Department of Dermatology, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Horm Metab Res 39:166-70. 2007..Among them, corticotropin-releasing hormone (CRH) was currently found to be produced also in the skin...
- Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditionsS Silberstein
Laboratorio de Fisiologia y Biologia Molecular, Departamento de Fisiología y Biología y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and IFIBYNE CONICET, Ciudad Universitaria, Buenos Aires, Argenita
Neuroscience 159:610-7. 2009Corticotropin-releasing hormone (CRH) coordinates neuroendocrine and behavioral adaptations to stress...
- Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalisS Erb
Centre for the Neurobiology of Stress, Department of Life Science and Psychology, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario M1C 1A4, Canada
Neuroscience 123:1003-9. 2004The neuropeptide, corticotropin-releasing hormone (CRH), has been shown to play a role in behavioral and neurobiological effects of drugs of abuse...
- Bombesin and ceruletide-induced grooming and inhibition of ingestion in the ratP J Kulkosky
Department of Psychology, University of Southern Colorado, Pueblo 81001
Ann N Y Acad Sci 525:201-18. 1988..exhibits short-term cross-tolerance with ACTH in elicitation of grooming, and central CCK-8 is co-localized with CRF and stimulates ACTH and corticosterone release in the rat...
- Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studiesM Kumari
Department of Pharmacology, Charing Cross and Westminister Medical School, London
Br J Pharmacol 121:459-68. 1997..001) and BRL 61063 (1 and 10 microM, P < 0.05) stimulated the release of corticotrophin releasing hormone (ir-CRH-41) but lower concentrations of the drugs were without effect as also was BRL 61063 at 100 microM (P > 0...
- High-affinity uptake of noradrenaline in postsynaptic neuronesS al Damluji
Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, MD 20892
Br J Pharmacol 109:299-307. 1993..isomer 6-hydroxydopamine was used, suggested that the post synaptic uptake process is operative in hypothalamic CRH and vasopressin neurones in vivo.11...
- Neuroendocrinology of the pituitary glandS Reichlin
Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111
Toxicol Pathol 17:250-5. 1989..Specific neuropeptides have been isolated which stimulate the secretion of ACTH (CRF, corticotrophin releasing hormone), TSH (TRH, thyrotropin releasing hormone), GH (GHRH, growth hormone releasing ..
- Corticotropin-releasing factor induces phosphorylation of phospholipase C-gamma at tyrosine residues via its receptor 2beta in human epidermoid A-431 cellsJ G Kiang
Department of Clinical Physiology, Division of Medicine, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
Eur J Pharmacol 363:203-10. 1998This laboratory previously reported that corticotropin-releasing factor (CRF) increased intracellular free calcium concentrations, cellular cAMP, inositol 1,4,5-trisphosphate, protein kinase C activity, and protein phosphorylation in ..
- Changes in physiological and neuroendocrine properties during thermal adaptation of golden hamsters (Mesocricetus auratus)J Roth
Physiologisches Institut, Giessen, Federal Republic of Germany
J Comp Physiol B 160:153-9. 1990..hamsters the brains were processed for immunocytochemical detection of arginine-vasopressin (AVP) and corticotropin releasing factor (CRF) in the third week of adaptation to a cold or warm environment...
- Aberrant production and regulation of proopiomelanocortin-derived peptides in ectopic Cushing's syndromeK A Roth
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri
Horm Metab Res 20:225-9. 1988..In dispersed monolayer culture, CRF failed to elicit ACTH release from the tumor cells, but dexamethasone caused a paradoxical increase in ACTH ..
- Corticotropin-releasing factor receptor expression in the pituitary of fetal sheep after lesion of the hypothalamic paraventricular nucleusD A Myers
Department of Physiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
Endocrinology 140:4292-9. 1999Both the capacity of CRF to release ACTH and the number of binding sites for CRF in the anterior pituitary decline during the final weeks of gestation in fetal sheep...
- A role for corticotropin releasing factor and urocortin in behavioral responses to stressorsG F Koob
Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
Brain Res 848:141-52. 1999Corticotropin-releasing factor (CRF) and CRF-related neuropeptides have an important role in the central nervous system to mediate behavioral responses to stressors...
- Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypesLin Lu
Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
J Neurochem 84:1378-86. 2003..DA) release in nucleus accumbens and ventral tegmental area by the non-specific corticotropin-releasing factor (CRF) receptors antagonist alpha-helical CRF, the selective CRF receptor subtype 1 antagonist CP-154,526 and the ..
- Characterization of the effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in Brown Norway and Wistar-Kyoto ratsLisa H Conti
Department of Psychiatry, MC 1410, University of Connecticut Health Center, Farmington, CT 06030, USA
Eur J Pharmacol 507:125-34. 2005..prepulse inhibition is decreased by central administration of the neuropeptide, corticotropin-releasing factor (CRF) in both strains...
- Effects of corticotropin-releasing factor on prepulse inhibition of the acoustic startle response in two rat strainsLisa H Conti
Department of Pharmacology, 0636, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
Psychopharmacology (Berl) 161:296-303. 2002..Corticotropin-releasing factor (CRF), a neurotransmitter that is released during stress, and CRF receptors are expressed in areas of the brain which ..
- Effects of pyrogenic immunomodulators on the release of corticotrophin-releasing factor-41 and prostaglandin E2 from the intact rat hypothalamus in vitroN G Milton
Department of Clinical Biochemistry, University of Newcastle upon Tyne
Br J Pharmacol 109:88-93. 1993..interleukin (IL)-1 alpha and IL-1 beta, human IL-6 and rat interferon (INF) on corticotrophin-releasing factor-41 (CRF-41) and prostaglandin E2 (PGE2) release from the intact rat hypothalamus in vitro have been studied. 2...
- Relaxing actions of corticotropin-releasing factor on rat resistance arteriesS Lei
Danish Biomembrane Research Centre, Aarhus University
Br J Pharmacol 108:941-7. 19931. Although it well established that corticotropin-releasing factor (CRF) injected i.v. can cause hypotension and vasodilatation, there is no in vitro evidence that CRF acts as a vasodilator...
- [Relationship between the central renin-angiotensin system, stress and hypertension]E C Dumont
Centre de Recherche du CHUL, , , Canada
Arch Mal Coeur Vaiss 92:1111-3. 1999..Among the central neurochemical systems, CRF and the renin-angiotensin may represent major modulatory systems involved in the adaptation of an organism to ..
- The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonistT Z Baram
Department of Pediatrics, University of California, Irvine 92697 4475, USA
Brain Res 770:89-95. 1997b>Corticotropin releasing factor (CRF) is the key coordinator of the neuroendocrine and behavioral responses to stress...
- CRF and stress in fishGert Flik
Department of Animal Physiology, Institute for Neuroscience, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
Gen Comp Endocrinol 146:36-44. 2006..Key players in the continuous adaptation process are corticotropin-releasing factor (CRF) from the hypothalamic nucleus preopticus (NPO), pituitary adrenocorticotropic hormone (ACTH) and cortisol produced ..
- Some functional aspects of canine corticotrophsD J Middleton
Faculty of Veterinary Medicine, Division of Comparative Endocrinology, State University, Utrecht, The Netherlands
Horm Metab Res 19:632-5. 1987..and functional significance of canine pituitary pars intermedia corticotrophs, ACTH and cortisol responses to CRF were studied in healthy dogs before and after treatment with dexamethasone...
- Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic ratsEwa Lewin
Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Kidney Int 64:63-70. 2003..Our aim was to search for the PTH/PTHrP receptor in rat parathyroid glands and to examine the effects of PTHrP 1-40 on PTH secretion in in vivo models of secondary hyperparathyroidism (HPT) in uremic rats...
- Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stressS B Pinnock
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY UK
Eur J Neurosci 13:576-84. 2001..restraint stress induces well-characterized adaptations in the expression of either corticotropin-releasing factor (CRF) or arginine-vasopressin (AVP) mRNA in the parvocellular neurons of the hypothalamic paraventricular nucleus (PVN)...
- Stimulation of the inferior olivary complex alters the distribution of the type 1 corticotropin releasing factor receptor in the adult rat cerebellar cortexJ B Tian
Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
Neuroscience 153:308-17. 2008..populations of climbing fibers, derived from the inferior olivary complex (IOC) contain the peptide corticotropin releasing factor (CRF) and that the expression of this peptide in climbing fibers could be modulated by the level of ..
- Direct effects of stress on adrenocortical functionD Pignatelli
Institute of Histology and Embryology, Faculty of Medicine of Porto, Portugal
Horm Metab Res 30:464-74. 1998..as well as the existence of some local hormonal axis such as those resulting from the local production of renin or CRH in adrenal cells...
- [Progressive cerebellar ataxia with diencephalic symptoms (Toyokura)--a case report]M Kitsu
Department of Pediatrics, Neurological Institute, Tokyo Women's Medical College
No To Hattatsu 24:273-7. 1992..responded to the loading of hypothalamic hormones such as growth hormone releasing factor and corticotropin releasing factor, in spite of poor responses of GH under the insulin stimulation or sleep...
- Differential roles of corticotropin-releasing factor receptor subtypes 1 and 2 in opiate withdrawal and in relapse to opiate dependenceL Lu
National Laboratory of Medical Neurobiology, Shanghai Medical University, 138 Yi Xue Yuan Road, Shanghai 200032, P R China
Eur J Neurosci 12:4398-404. 2000The possible effects on the morphine withdrawal signs of the nonspecific corticotropin-releasing factor (CRF) receptor antagonist alpha-helical CRF, the selective CRF receptor subtype 1 antagonist CP-154,526 and the selective CRF ..
- Signaling properties of mouse and human corticotropin-releasing factor (CRF) receptors: decreased coupling efficiency of human type II CRF receptorY Xiong
Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
Endocrinology 136:1828-34. 1995b>CRF is the primary neuroregulator of the function of the hypothalamic-pituitary-adrenal axis. We have recently cloned a mouse CRF receptor (mCRF-R) complementary DNA (cDNA) from an AtT-20 cell cDNA library by polymerase chain reaction...
- [Seizures associated with fever in children of congenital adrenal hyperplasia]H Kawawaki
Division of Pediatric Neurology, Osaka City General Hospital, Osaka
No To Hattatsu 33:27-30. 2001..hyponatremia), our findings implicate unknown factors in the pathogenesis such as excess secretion of corticotropin releasing factor (CRF) under stress, prolonged elevation of CRF during fetus life and linkage between CAH and febrile ..
- Treatment of periorbital edema with human corticotropin-releasing factor after blepharoplastyS A Schendel
Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Stanford, CA 94305 USA
J Am Coll Surg 182:226-32. 1996..Further research with a larger study population and other dosing regimens is indicated...
- Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptidesBhawanjit K Brar
The Clayton Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Endocrinology 145:1718-29. 2004Corticotropin-releasing factor (CRF) receptor (CRFR)-mediated activation of the ERKs 1/2-p42 and -44) has been reported for CRF, urocortin (Ucn)-I, and sauvagine...
- Central neuropeptide Y and the sigma ligand, JO 1784, reverse corticotropin-releasing factor-induced inhibition of gastric acid secretion in ratsM Gue
CURE VA Wadsworth Medical Center, Department of Medicine, Los Angeles, CA
Br J Pharmacol 107:642-7. 1992..en-1-ylamine hydrochloride], or neuropeptide Y (NPY) and corticotropin-releasing factor (CRF)-induced inhibition of gastric acid secretion were investigated in rats anaesthetized with urethane...
- Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovaryH Asakura
Department of Reproductive Medicine, University of California San Diego School of Medicine, La Jolla 92093 0633, USA
J Clin Endocrinol Metab 82:2720-5. 1997..corticotropin-releasing factor (IrCRF) in the thecal-stromal cells of the human ovary and the ability of CRF to suppress estrogen production by human granulosa cells in vitro have been reported...
- Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellumJames S King
Department of Neuroscience, The Ohio State University, 333 W 10th Ave Columbus, Ohio 43210, USA
J Neurocytol 32:305-16. 2003b>Corticotropin releasing factor (CRF) is present in the adult, as well as in the embryonic and postnatal rodent cerebellum. Further, the distribution of the type 1 CRF receptor has been described in adult and postnatal animals...
- Identification of two corticotropin-releasing factor receptors from Xenopus laevis with high ligand selectivity: unusual pharmacology of the type 1 receptorF M Dautzenberg
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Goettingen, Germany
J Neurochem 69:1640-9. 1997Two cDNA clones encoding distinct members of the corticotropin-releasing factor (CRF) receptor family have been isolated from Xenopus laevis with PCR-based approaches...
- Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indicationsJ R McCarthy
Neurocrine Biosciences, Inc, San Diego, CA 92121, USA
Curr Pharm Des 5:289-315. 1999Corticotropin-releasing factor (CRF) has been widely implicated as playing a major role in modulating the endocrine, autonomic, behavioral and immune responses to stress...
- Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient miceShoko Kawashima
Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
Peptides 29:2169-74. 2008..Corticotropin-releasing factor (CRF) is a candidate for mediating the anorexic effect of alpha-MSH...
- Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonistsJ Rivier
The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
J Med Chem 45:4737-47. 2002We present evidence that members of the corticotropin releasing factor (CRF) family assume distinct structures when interacting with the CRF(1) and CRF(2) receptors...
- The effect of restraint stress on prepulse inhibition and on corticotropin-releasing factor (CRF) and CRF receptor gene expression in Wistar-Kyoto and Brown Norway ratsJane E Sutherland
Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
Pharmacol Biochem Behav 97:227-38. 2010..Corticotropin-releasing factor (CRF) is one of the most important neurotransmitters involved in behavioral components of the stress response, and ..
- Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the ratM Gue
Department of Pharmacology, INRA, Toulouse, France
Br J Pharmacol 111:930-4. 19941. The role of dopamine in the genesis of corticotropin releasing factor (CRF)- and emotional stress (ES)-induced stimulation of colonic motility, as well as the mechanism of antagonistic action of cholecystokinin octapeptide (CCK-8s) and ..
- Determining the role of RFRP-3 in stress-related female infertilityMOLLY JOANNE DICKENS; Fiscal Year: 2013..to isolate and precisely analyze relative glucocorticoid and corticotropin releasing hormone receptors (GR and CRH-R1, respectively) on RFRP-3 neurons...
- Effects of early-life experience:role of CRHTallie Z Baram; Fiscal Year: 2013..persistent alterations of stress-related genes: reduced expression of hypothalamic corticotropin releasing hormone (CRH) was found by the applicant already by the end of the enriched-experience period on postnatal day 9, preceding ..
- Stress Effects on Alcohol Consumption: Age of onset and genes in heavy drinkersGary S Wand; Fiscal Year: 2013..Genetic variation in the corticotropin-releasing hormone (CRH) receptor 1 also has been associated with stress-induced heavy alcohol consumption in animals and human adolescents;..
- The Effect of Corticotropin Releasing Hormone on Cortical ArousalRoyce Lee; Fiscal Year: 2010This R21 project proposes to develop a novel pharmacological-EEG probe of central corticotropin- releasing hormone (CRH) receptor function suitable for clinical research...
- CRH Receptors and Stress Response PathwaysMary Stenzel Poore; Fiscal Year: 2007..We propose that corticotropin-releasing hormone (CRH) and its receptors are critical in achieving proper initiation and termination responses to stress...
- GR-Mediated Epigenetic Regulation of the CRH GeneROSALIE MARIE UHT; Fiscal Year: 2013..that synthesize and secrete the peptide that triggers the stress response, corticotropin-releasing hormone (CRH), are insensitive to glucocorticoid down-regulation...
- Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal AxisRobert J Handa; Fiscal Year: 2013..the paraventricular nucleus of the hypothalamus (PVN) that synthesize and secrete corticotropin-releasing hormone (CRH)...
- TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUSRONALD MICHAEL LECHAN; Fiscal Year: 2010..by cAMP-response element modulator (CREM), inducible cAMP early repressor (ICER), corticotropin-releasing hormone (CRH) and the role of increased T3 levels in the mediobasal hypothalamus as a result of endotoxin-induced increased type ..
- Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo UsNikolaos Makris; Fiscal Year: 2010..in patients with major depressive disorder (MDD), in PVN neurons that are dense in corticotropin releasing hormone (CRH) and estrogen receptor (ER)1...
- Melanocortin system stress and HPA axisXin Yun Lu; Fiscal Year: 2010..Corticotropin-releasing hormone (CRH) plays a pivotal role in the mediation of stress responses, particularly HPA activation...
- Amygdala CRH, Insomnia and DepressionRong Zhang; Fiscal Year: 2012DESCRIPTION (provided by applicant): Stress exposure stimulates the release of corticotropin releasing hormone (CRH) in the brain and activates the hypothalamus-pituitary-adrenal (HPA) axis, which is key mechanism of stress regulation...
- Stress-induced hypertension and the role of the neuroimmune systemPAUL MARVAR; Fiscal Year: 2012..e. elevation of blood pressure, increased catecholamines and corticotropin-releasing hormone (CRH) release...
- Brain mast cells and Chronic Fatigue SyndromeTheoharis C Theoharides; Fiscal Year: 2013..Brain mast cells are abundant in the median eminence where they are juxtaposed to corticotropin-releasing hormone (CRH)-positive neurons and CRH is secreted under stress and we showed that CRH activates mast cells through CRHR-1 ..
- DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESNed H Kalin; Fiscal Year: 2013..evidence implicates increased central nucleus of the amygdala (CeA) activity and corticotropin-releasing hormone (CRH) system activity as factors underlying the risk to develop anxiety and depressive disorders...
- CORTICOTROPIN RELEASING HORMONE SIGNALING AND NEWBORN NEURON CIRCUIT INTEGRATIONIsabella Garcia; Fiscal Year: 2013..We have identified a subpopulation of local Corticotropin-Releasing Hormone (CRH)-expressing neurons that provide selective and extensive inputs onto newborn granule cells...
- Neuroimmune Mechanisms of Glucocorticoid ResistanceAndrew H Miller; Fiscal Year: 2010..is believed to contribute to excessive inflammation as well as hyperactivity of corticotropin releasing hormone (CRH) and sympathetic nervous system pathways, which may contribute to behavioral alterations...
- Phenotypic and Functional Determination of Central Extended Amygdala Cell GroupsHEIDI E DAY; Fiscal Year: 2010..Furthermore, this receptor is expressed on cells of the lateral CEA that contain corticotropin releasing hormone (CRH) and dynorphin, but is not expressed on cells that contain enkephalin, or on cells of the medial CEA, a major ..
- AMYGDALA GLUCOCORTICOID RECEPTOR FUNCTION IN STRESSLOUIS JOSEPH MUGLIA; Fiscal Year: 2013..in the CeA regulate behavioral and adrenal responses to stress by control of corticotropin-releasing hormone (CRH) gene expression at this site...
- Stress Hormones and Chondrogenic Vascular CalcificationJODI FRANCES EVANS; Fiscal Year: 2010..in Aim 3, the atherosclerosis-prone, ApoE-deficient mouse will be crossed with the corticotropin releasing hormone (CRH) deficient mouse...
- GABAergic and glucocorticoid regulation of CRH neurons and extinction of fearGEORGETTE MARIE GAFFORD; Fiscal Year: 2012..GABA inhibits corticotropin releasing hormone (CRH), a well characterized neuropeptide engaged during stress...
- Rehabilitation of Stress-Induced InsomniaPingfu Feng; Fiscal Year: 2009..have different mechanisms would improve sleep and suppress the brain levels of corticotropin-releasing hormone (CRH) and the orexins which are involved in the neurobiological pathology for insomnia, and to evaluate whether a long ..
- CRH in stress-induced hippocampal neuroplasticityTallie Z Baram; Fiscal Year: 2013..post hoc blocking of the receptor (CRFR1) of the stress-activated neuropeptide, corticotropin releasing hormone (CRH) immediately after the ES period, abrogated these deficits...
- Signal Processing in the Inner RetinaSteven H DeVries; Fiscal Year: 2013..amacrine cell type that expresses cre recombinase under the control of the corticotropin releasing hormone (CRH) promoter...
- Cytokine-CRH Interactions in IFN-alfa-Induced DepressionCharles Raison; Fiscal Year: 2009..depression and induce the production and release of central nervous system (CNS) corticotropin-releasing hormone (CRH), which is believed to be a key mediator of depression...
- CRH AND INFLAMMATION IN CEREBRAL ISCHEMIC INJURYMary Stenzel Poore; Fiscal Year: 2002..Corticotropin-releasing hormone (CRH), a neuropeptide first identified as a hypothalamic releasing hormone that mediates the stress response, is also ..
- Neural Priming of CRF-Mast Cell SignalingAdam Moeser; Fiscal Year: 2013..Previous work has demonstrated that corticotropin releasing factor (CRF), a small peptide released from the hypothalamus and intestinal tissues during the stress ..
- Adolescent Alcohol,Dysregulated Stress System, and PTSD VulnerabilityGERHARD H SCHULTEIS; Fiscal Year: 2013..A further prediction is that corticotropin releasing factor (CRF) and/or norepinephrine (NE) systems in the CNS are central to the potentiative effects of ethanol ..
- Brain-derived neurotrophic factor induced weight loss: neural mechanismsChuanfeng Wang; Fiscal Year: 2012..indicate that: 1) blockade of BDNF binding to TrkB receptor attenuates BDNF-inhibited feeding;2) blockade of CRH receptor (CRHR) signaling attenuates BDNF-inhibited feeding;and 3) chronic (14 d) injection of BDNF reduces feeding ..
- Central neural function of Urocortin 3 in regulating energy balanceChien Li; Fiscal Year: 2013..The receptor for Ucn 3, the type 2 CRF receptor (CRFR2), is highly expressed in the VMH and its expression is regulated by the energy status of the ..
- NEUROPEPTIDES AND THEIR PHYSIOLOGICAL CONTROLAlan G Watts; Fiscal Year: 2013..the structural and functional organization of the neural networks responsible for controlling neuroendocrine CRH neurons in the paraventricular nucleus of the hypothalamus (PVH)...
- Enteric CRF Receptor Signaling in Stress-Induced Intestinal Barrier DysfunctionAdam Moeser; Fiscal Year: 2013..In previous animal studies, we demonstrated that enteric corticotrophin releasing factor (CRF) and its receptors play a major role in stress-induced breakdown of intestinal barrier function characterized by ..
- Sex Differences in Stress Receptors Underlie Female Vulnerability to StressDebra A Bangasser; Fiscal Year: 2012..Corticotropin-releasing factor (CRF) orchestrates stress responses, in part, by regulating norepinephrine (NE) and serotonin (5-HT) transmission, and ..
- Regulation and Function of Urocortins and their ReceptorsAditi Bhargava; Fiscal Year: 2013PROJECT SUMMARY/ABSTRACT The corticotropin-releasing factor (CRF) family of neuropeptides (CRF and urocortins [Ucn] 1-3) and their receptors (CRFR1, CRFR2) are essential mediators of stress in the central nervous system...
- Mechanisms of Postoperative IleusYVETTE FRANCE TACHE; Fiscal Year: 2012..novel preliminary data, that abdominal surgery recruits stress- related mechanisms, most prominently corticotropin releasing factor (CRF) receptor 2 (CRF2) system in the brain and the gut, which contributes to orchestrate alterations ..
- Sex and Stress Mechanisms of Vulnerability to AddictionRajita Sinha; Fiscal Year: 2011..Our preliminary data demonstrate a role for the stress hormone, corticotropin-releasing factor (CRF), in the behavioral, neurochemical and molecular responses to cocaine...
- Sex Differences in Stress Receptors Underlie Female Vulnerability to StressDebra A Bangasser; Fiscal Year: 2013..Corticotropin-releasing factor (CRF) orchestrates stress responses, in part, by regulating norepinephrine (NE) and serotonin (5-HT) transmission, and ..
- Arrestin Regulation of CRF1 Signaling: Mechanisms for Stress Resilience and PTSDRichard L Hauger; Fiscal Year: 2013DESCRIPTION (provided by applicant): The central CRF system is a critical mediator of behavioral, cognitive, HPA axis, and autonomic responses to stress and trauma...
- BIOLOGY OF NEUROENDOCRINE PEPTIDESMarc R Montminy; Fiscal Year: 2013..explore the physiologic and pathophysiologic roles and signaling of receptors and ligands related to corticotropin releasing factor (CRF), a peptide we chemically identified at the inception of the Program...
- GCs, CRF and Stressor-Induced RelapseJohn R Mantsch; Fiscal Year: 2013..research has shown that stressor- induced cocaine seeking is mediated in part by corticotropin-releasing factor (CRF) stimulation of a neurobiological pathway involving dopamine (DA) neurons in the ventral tegmental area (VTA) that ..
- Novel mechanism-based treatments for infantile spasmsLIBOR VELISEK; Fiscal Year: 2010..2) Prenatal priming upregulates expression of corticotropin releasing factor (CRF) in the Arc...
- Hypothalamic Neuronal Plasticity in Chronic StressDe Pei Li; Fiscal Year: 2013..Stimulation of corticotrophin-releasing hormone (CRH)-expressing parvocellular neurons increases pituitary adrenocorticotropic hormone (ACTH) release and subsequent ..
- The dorsal raphe and CRF: making the connectionsMichael S Clark; Fiscal Year: 2010..Previous studies have suggested that corticotropin releasing factor (CRF) receptor activation in the dorsal raphe, a major source of serotonin to the forebrain, is a ..
- Edinger-Westphal Urocortin-1 Involvement in Binge Ethanol Intake and RewardWilliam J Giardino; Fiscal Year: 2013..populations, evidence supports a role for neural stress networks, such as the corticotropin-releasing factor (CRF) system, in excessive EtOH intake...
- Sex differences in the corticotropin-releasing factor receptorDEBRA WAXLER BANGASSER; Fiscal Year: 2010..Dysfunctions in corticotropin-releasing factor (CRF), the neuropeptide that orchestrates the stress response, have been linked to depression and anxiety disorders...
- Neural Substrates of Phasic versus Sustained FearDavid L Walker; Fiscal Year: 2013..focuses attention on the bed nucleus of the stria terminalis (BNST) and the stress-related peptide corticotropin releasing factor (CRF)...
- MORPHINE ACTIONS ON THE IMMUNE SYSTEMSulie L Chang; Fiscal Year: 2012..brain involved in the activation of the HPA axis, thus, inhibiting IL-I f3-induced transcription of corticotropin releasing factor mRNA by the hypothalamus and decreasing the production of anti-inflammatory agents, such as ..
- Mechanisms Underlying Stress ResilienceJanice H Urban; Fiscal Year: 2013..and excitatory tone which is modulated, in part, by neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF). In the BLA, NPY not only buffers the actions of CRF, but produces long term stress resilience...
- Brain Noradrenergic Neurons Peptides and StressRITA VALENTINO; Fiscal Year: 2012..Specifically, this research examines how the stress neuromediator, corticotropin-releasing factor (CRF) regulates activity of the locus coeruleus (LC)-norepinephrine (NE) system, a neural system involved in emotional ..
- CRF regulation of BNST target control in alcohol withdrawalYuval Silberman; Fiscal Year: 2012..amygdala, a brain region important in mediating anxiety and stress responses, and corticotrophin releasing factor (CRF), a neurotransmitter thought to be involved in stress reactivity, are thought to be heavily involved in the ..
- Alcohol - Induced Effects on Stress-Realted CircuityTARA RETSON; Fiscal Year: 2013..provided by applicant): This project focuses on the stress-related peptide corticotropin-releasing factor (CRF), and the limbic-norepinephrine (NE) arousal system, as a target impacted by chronic alcohol exposure whose ..
- Upstream control and downstream effects of NPS releaseOlivier Civelli; Fiscal Year: 2013..As a first result of these investigations, we have discovered functional receptors for the neuropeptide CRF, which is a key transmitter in mediating stress and anxiety behaviors...
- Actions of CRF on 5-HT pathways in mood regulationTracy L Bale; Fiscal Year: 2013..disease, which has promoted the pharmaceutical pursuit of therapeutic targets including antagonists of the CRF receptor-1 (CRFR1) that would blunt this response...
- Ghrelin antogonism and excessive drinkingAndrey E Ryabinin; Fiscal Year: 2013..is the main brain source of the neuropeptide urocortin 1 (Ucn1, a highly potent endogenous ligand of corticotropin releasing factor receptors) and has been shown to be highly sensitive to ethanol and be involved in regulation of ..
- Developmental plasticity of micturation reflexesMARGARET ANN VIZZARD; Fiscal Year: 2012..may be mediated by multiple factors, including upregulation of mature supraspinal mechanisms (corticotropin releasing factor, CRF/CRF receptor system) and changes in neuron and target organ (postganglionic neuronyenurinary ..
- Stress and CRF System Effects on Information ProcessingVictoria B Risbrough; Fiscal Year: 2013..use murine models to elucidate the mechanisms underlying the effects of stress and the neuropeptide corticotropin releasing factor (CRF) on anxiety-like behavior related to post-traumatic stress disorder (PTSD)...
- DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIAMark A Geyer; Fiscal Year: 2010..the endogenous NMDA receptor antagonist, kynurenic acid (KYNA), and the stress-related neuropeptide, corticotropin releasing factor (CRF) in isolation- and immune-mediated developmental models of sensorimotor gating deficits...
- Corticotropin Releasing Factor: Impact on InflammationEric Smith; Fiscal Year: 2009..One of these leukocyte-derived neuropeptides, corticotropin releasing factor (CRF) is a particularly interesting regulator that has many effects on neuroendocrine and immune ..
- Neoropeptide Basis of Social Loss and DepressionLarry J Young; Fiscal Year: 2012..in depressive-like behavior following social loss appears to be mediated by the corticotropin-releasing factor (CRF) system, as blocking either of the CRF receptors (CRF1 or CRF2) prevents the onset of depressive-like behavior ..
- Regulation of Dorsal and Medial Raphe Neural ActivitySheryl G Beck; Fiscal Year: 2010..The excitatory neurotransmitter glutamate, the inhibitory neurotransmitter GABA and the stress hormone CRF are all posed to have selective and regionally distinct modulatory roles on DR and/or MR activity...
- The role of corticotropin releasing factor in binge-like ethanol drinkingTodd E Thiele; Fiscal Year: 2013..We have found that binge-like ethanol drinking increases corticotropin releasing factor (CRF) immunoreactivity (IR) in the central amygdala (CeA) and that a type-1 receptor (CRF1R) ..
- Neurochemical Manipulation of Withdrawal-Induced DrinkingDEBORAH ANN FINN; Fiscal Year: 2012..Finally, intra amygdala administration of the CRF receptor antagonist D-Phe-CRF(12-41) also selectively decreased the high alcohol intake in the MW group without ..
- Modulation of Fear Memory by Corticotropin-Releasing Factor in the AmygdalaElizabeth P Bauer; Fiscal Year: 2011..The neuropeptide corticotropin-releasing factor (CRF) is released throughout the brain under conditions of stress and anxiety...
- Mast cells, antidepressants and chronic fatigue syndromeTheoharis Theoharides; Fiscal Year: 2007..b) acute stress activates mast cells, an action blocked by pretreatment with corticotropin-releasing hormone (CRH) neutralizing antiserum, (c) stress increases blood-brain-barrier (BBB) permeability, which is inhibited by the CRH-..
- Neural Analysis of Maternal AggressionSTEPHEN GAMMIE; Fiscal Year: 2006..During lactation, decreases in corticotropin releasing hormone (CRH) neurotransmission have been linked to decreases in fear and anxiety...
- Restraint stress-induced neurogenic bladder inflammationTheoharis Theoharides; Fiscal Year: 2006..Corticotropin releasing hormone (CRH) is released from the hypothalamus under stress and activates the hypothalamic-pituitary-adrenal (HPA) axis...
- Role of CRH in skin physiology and pathologyAndrzej Slominski; Fiscal Year: 2004..Corticotropin releasing hormone (CRH) and CRH receptors (CRH-R) are also expressed and fully functional in rodent and human skin, but its significance ..
- Corticotropin-Releasing Hormone-Binding ProteinAUDREY SEASHOLTZ; Fiscal Year: 2004DESCRIPTION: (Scanned from the applicant's abstract) Corticotropin-releasing hormone (CRH) is widely recognized as the key physiological regulator of the mammalian stress response...
- Studies of CRH and Alcohol EffectsTamara Phillips; Fiscal Year: 2005..We shall focus on the role of corticotropin-releasing hormone (CRH), the critical mediator of the stress response, in determining these alcohol effects...
- Form/function of Extended Amygdala/Accumbens Shell:CRFDANIEL ZAHM; Fiscal Year: 2005Corticotropin-releasing factor (CRF) is the major mediator of stress responses in the brain and has been implicated in both normal fear and pathological anxiety...