CPT1A

Summary

Gene Symbol: CPT1A
Description: carnitine palmitoyltransferase 1A
Alias: CPT1, CPT1-L, L-CPT1, carnitine O-palmitoyltransferase 1, liver isoform, CPT I, CPTI-L, carnitine O-palmitoyltransferase I, liver isoform, carnitine palmitoyltransferase 1A (liver), carnitine palmitoyltransferase I, liver
Species: human

Top Publications

  1. ncbi Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia
    Stephanie Gobin
    INSERM U393, Groupe Hospitalier Necker Enfants Malades, Paris, France
    Hum Genet 111:179-89. 2002
  2. ncbi Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?
    Paola Mazzarelli
    Institute of Anatomic Pathology, Dept of Biopathology, University of Rome Tor Vergata, Rome, Italy
    Cancer Biol Ther 6:1606-13. 2007
  3. ncbi tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1
    A Giordano
    Institute of Protein Biochemistry IBP, CNR, Naples, Italy
    Cell Death Differ 12:603-13. 2005
  4. ncbi Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations
    E Verderio
    Divisione di Biochimica e Genetica, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Hum Mol Genet 4:19-29. 1995
  5. doi Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations
    A I Sironen
    Agrifood Research Finland, MTT, Biotechnology and Food Research, Genomics, FI 36100 Jokioinen, Finland
    J Anim Sci 88:821-7. 2010
  6. ncbi A novel brain-expressed protein related to carnitine palmitoyltransferase I
    Nigel Price
    Hannah Research Institute, Ayr, KA6 5HL, UK
    Genomics 80:433-42. 2002
  7. ncbi Rationale for a conditional knockout mouse model to study carnitine palmitoyltransferase I deficiencies
    F R van der Leij
    Department of Pediatrics, Groningen Utrecht Institute for Drug Exploration, University of Groningen, The Netherlands
    Adv Exp Med Biol 466:377-85. 1999
  8. ncbi Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
  9. doi Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows
    H A van Dorland
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
    J Dairy Sci 92:1924-40. 2009
  10. pmc Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice
    Kristoffer Ström
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 3:e1793. 2008

Research Grants

  1. THE CARNITINE TRANSPORTER IN HUMAN DISEASE
    Nicola Longo; Fiscal Year: 2010
  2. NMR OF MITOCHONDRIAL TRANSPORTERS IN CARDIAC HYPERTROPHY
    E Douglas Lewandowski; Fiscal Year: 2013
  3. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
  4. Leigh Goedeke; Fiscal Year: 2014
  5. Regulated Expression of Hypothalamic CPT1 Using Gutless Adenovirus
    Silvana Obici; Fiscal Year: 2010
  6. A MOUSE MODEL FOR HUMAN INHERITED DISEASES
    Philip A Wood; Fiscal Year: 2010
  7. Carlos Fernandez Hernando; Fiscal Year: 2016
  8. BRAIN SOCS3 AND PTP1B-ADIPOSE LEPTIN FEEDBACK AXIS IN ALCOHOLIC HEPATOSTEATOSIS
    Raj M Lakshman; Fiscal Year: 2011
  9. Hypothalamic Fatty Acid Sensing in Aging
    Rachel Ross; Fiscal Year: 2010
  10. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007

Detail Information

Publications258 found, 100 shown here

  1. ncbi Organization of the human liver carnitine palmitoyltransferase 1 gene ( CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia
    Stephanie Gobin
    INSERM U393, Groupe Hospitalier Necker Enfants Malades, Paris, France
    Hum Genet 111:179-89. 2002
    Carnitine palmitoyltransferase 1A (CPT1A) deficiency is a rare autosomal recessive disorder of mitochondrial fatty acid oxidation. CPT1 controls the import of long-chain fatty acids into the mitochondria, where they are oxidized...
  2. ncbi Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?
    Paola Mazzarelli
    Institute of Anatomic Pathology, Dept of Biopathology, University of Rome Tor Vergata, Rome, Italy
    Cancer Biol Ther 6:1606-13. 2007
    ..We also identified the existence of CPT1A mRNA transcript variant 2 in MCF-7, beside to the classic isoform 1...
  3. ncbi tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1
    A Giordano
    Institute of Protein Biochemistry IBP, CNR, Naples, Italy
    Cell Death Differ 12:603-13. 2005
    ....
  4. ncbi Carnitine palmitoyltransferase II deficiency: structure of the gene and characterization of two novel disease-causing mutations
    E Verderio
    Divisione di Biochimica e Genetica, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Hum Mol Genet 4:19-29. 1995
    ..To facilitate the identification of disease-causing mutations in the CPT II gene (CPT1), we have established the genomic organization of this gene...
  5. doi Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations
    A I Sironen
    Agrifood Research Finland, MTT, Biotechnology and Food Research, Genomics, FI 36100 Jokioinen, Finland
    J Anim Sci 88:821-7. 2010
    ..Significant effects on farrowing time were detected from the Yorkshire data, with polymorphisms within the genes CPT1A [a (allele substitution effect of allele A) = 2.97 d for age at first farrowing)], IGFBP3 (a = 0...
  6. ncbi A novel brain-expressed protein related to carnitine palmitoyltransferase I
    Nigel Price
    Hannah Research Institute, Ayr, KA6 5HL, UK
    Genomics 80:433-42. 2002
    ..of fatty acid synthesis and an inhibitor of the two known isoforms of carnitine palmitoyltransferase I (CPT I), which control mitochondrial fatty acid oxidation...
  7. ncbi Rationale for a conditional knockout mouse model to study carnitine palmitoyltransferase I deficiencies
    F R van der Leij
    Department of Pediatrics, Groningen Utrecht Institute for Drug Exploration, University of Groningen, The Netherlands
    Adv Exp Med Biol 466:377-85. 1999
    ..Of this enzyme, two isoforms are expressed in the neonatal heart: L-CPT1 (the "liver-type" isoform) and M-CPT1 (the "muscle-type" isoform)...
  8. ncbi Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Motoyuki Kohjima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Int J Mol Med 20:351-8. 2007
    ..protein (ADRP) for evaluation of de novo synthesis and uptake of fatty acids; carnitine palmitoyltransferase 1a; (CPT1a), long-chain acyl-CoA dehydrogenase (LCAD), long-chain L-3-hydroxyacylcoenzyme A dehydrogenase alpha (HADHalpha), ..
  9. doi Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows
    H A van Dorland
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
    J Dairy Sci 92:1924-40. 2009
    ..In conclusion, metabolic regulation in dairy cows is a dynamic system, and differs obviously between cows at different metabolic stages related to parturition...
  10. pmc Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice
    Kristoffer Ström
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    PLoS ONE 3:e1793. 2008
    ..Despite its role in fatty acid mobilization, HSL null mice have been shown to be resistant to diet-induced obesity...
  11. ncbi Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype
    Yan Weng
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York, Albany, New York 12201, USA
    J Biol Chem 280:31686-98. 2005
    ..induction of a fatty-acid translocase (Cd36 antigen) and the suppression of carnitine O-palmitoyltransferase 1 (Cpt1a) and acyl-CoA synthetase long chain family member 1 (Acsl1), that are potentially responsible for the severe ..
  12. pmc Skeletal muscle group VIA phospholipase A2 (iPLA2beta): expression and role in fatty acid oxidation
    Michael J Carper
    Mass Spectrometry Resource, Division of Metabolism, Endocrinology, and Lipid Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 47:12241-9. 2008
    ..oxidize palmitate but not palmitoyl-CoA or acetyl-CoA in the absence of changes in fatty acid transporters CD36 and CPT1 or beta-hydroxyacyl-CoA dehydrogenase activity...
  13. ncbi Studies employing Saccharomyces cerevisiae cpt1 and ept1 null mutants implicate the CPT1 gene in coordinate regulation of phospholipid biosynthesis
    S C Morash
    Department of Molecular Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 269:28769-76. 1994
    The Saccharomyces cerevisiae CPT1 and EPT1 genes are structural genes encoding sn-1,2-diacylglycerol choline phosphotransferase and sn-1,2-diacylglycerol choline/ethanolamine phosphotransferase, respectively...
  14. ncbi Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation
    Malika Chegary
    Department of Clinical Chemistry, Laboratory Genetic Metabolic Diseases F0 222, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Mol Genet Metab 93:403-10. 2008
    ..L-AC inhibits carnitine palmitoyltransferase (CPT) with different sensitivities towards CPT1 and CPT2, as well as carnitine acylcarnitine translocase (CACT)...
  15. pmc Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae
    T P McGee
    Department of Cell Biology, University of Alabama at Birmingham 35294 0005
    J Bacteriol 176:6861-8. 1994
    ..reduction in bulk membrane PC content was observed for both choline kinase (cki) and choline phosphotransferase (cpt1) mutants, but it was not observed for mutants defective in cholinephosphate cytidylyltransferase, the enzyme that ..
  16. pmc Disorders of carnitine transport and the carnitine cycle
    Nicola Longo
    Division of Medical Genetics, Department of Pediatrics, University of Utah, 2C412 SOM, 50 North Medical Drive, Salt Lake City, UT, USA
    Am J Med Genet C Semin Med Genet 142:77-85. 2006
    ..cell (OCTN2 carnitine transporter), conjugate it with long chain fatty acids (carnitine palmitoyl transferase 1, CPT1), transfer the acylcarnitine across the inner plasma membrane (carnitine-acylcarnitine translocase, CACT), and ..
  17. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
    ..We examined the effect of two mitochondrial nutrients, R-alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC), as well as their combined effect, on mitochondrial biogenesis in 3T3-L1 adipocytes...
  18. ncbi Effects of clofibrate treatment in laying hens
    B Konig
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Poult Sci 86:1187-95. 2007
    ..Because clofibrate treatment strongly reduced food intake in the hens, some of these effects (i.e., egg production) may have been due to a low energy and nutrient intake...
  19. pmc Phospholipid and cation activation of chimaeric choline/ethanolamine phosphotransferases
    C R McMaster
    Department of Molecular Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Biochem J 313:729-35. 1996
    The Saccharomyces cerevisiae CPT1 and EPT1 genes encode for a cholinephosphotransferase (CPT) and choline/ethanolaminephosphotransferase, respectively...
  20. pmc Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
    Kouichi Nakamura
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:9768-76. 2007
    ..whether PXR could cross-talk with the insulin response forkhead factor FoxA2 to repress the transcription of the Cpt1a and Hmgcs2 genes, because FoxA2 activates these genes in fasting liver...
  21. ncbi Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines
    Bettina König
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr Biochem 17:410-8. 2006
    ..of the PPARalpha target genes acyl-CoA oxidase (ACO), cytochrome P450 4A1 and carnitine-palmitoyltransferase 1A (CPT1A)...
  22. ncbi Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, H Collinstrasse 30, 1140 Vienna, Austria
    J Mol Med (Berl) 81:435-42. 2003
    ..MDS) with age, the aim of this study was to quantify mRNA synthesis of the carnitine palmitoyltransferases (CPT1 and CPT2), carnitine acetyltransferase (CRAT), human specific microsomal CPT, and OCTN2 (organic cation transporter)..
  23. ncbi Evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease
    Makoto Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Mol Med 16:631-5. 2005
    ..fatty acid synthase (FAS) for the evaluation of de novo fatty acid synthesis; carnitine palmitoyltransferase 1a (CPT1a), long-chain acyl-CoA dehydrogenase (LCAD), and long-chain L-3-hydroxyacyl-coenzyme A dehydrogenase alpha (..
  24. doi Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    Paulina Pettinelli
    Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Biochim Biophys Acta 1792:1080-6. 2009
    ....
  25. ncbi Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases
    R H Hjelmstad
    Department of Molecular Cancer Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 269:20995-1002. 1994
    The Saccharomyces cerevisiae CPT1 and EPT1 genes represent structural genes that encode distinct choline- and choline/ethanolaminephosphotransferases, respectively...
  26. doi Molecular characterization of a gilthead sea bream (Sparus aurata) muscle tissue cDNA for carnitine palmitoyltransferase 1B (CPT1B)
    Evridiki Boukouvala
    National Agricultural Research Foundation, Fisheries Research Institute, Nea Peramos, GR 64007 Kavala, Greece
    Comp Biochem Physiol B Biochem Mol Biol 157:189-97. 2010
    ..contain a single gene related to mammalian CPT1B, and a further two multi-gene families related to mammalian CPT1A. Genes related to mammalian CPT1C are absent in fish...
  27. doi Long-chain fatty acid effects on peroxisome proliferator-activated receptor-alpha-regulated genes in Madin-Darby bovine kidney cells: optimization of culture conditions using palmitate
    B J Thering
    Mammalian NutriPhysioGenomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA
    J Dairy Sci 92:2027-37. 2009
    ..was assessed by quantitative PCR of selected PPARalpha target genes as well as PPARalpha coactivators (ACOX1, CPT1A, ACADVL, ACSL1, PPARA, PPARGC1A, LPIN1)...
  28. doi Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells
    Jun Wan
    Department of Endocrinology, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu, Sichuan 610041, China
    Biochem Biophys Res Commun 391:1567-72. 2010
    ..GW-induced activation of PPARdelta up-regulated carnitine palmitoyltransferase 1 (CPT1), long-chain acyl-CoA dehydrogenase (LCAD), pyruvate dehydrogenase kinase 4 (PDK4), and uncoupling protein 2 (UCP2);..
  29. ncbi sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Mixed micellar analysis of the CPT1 and EPT1 gene products
    R H Hjelmstad
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 266:4357-65. 1991
    The Saccharomyces cerevisiae CPT1 and EPT1 genes are structural genes encoding distinct sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases...
  30. ncbi Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist
    Dennis L Sprecher
    GlaxoSmithKline, Department of Discovery Medicine Dyslipidemia, 709 Swedeland Road, UW2301, King of Prussia, PA 19406, USA
    Arterioscler Thromb Vasc Biol 27:359-65. 2007
    ..In parallel, PPARdelta agonist-upregulated FAO would induce fatty-acid uptake (via peripheral lipolysis), and influence HDLc and TG-rich lipoprotein particle metabolism, as suggested in preclinical models...
  31. doi CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity
    Adriana Y Sierra
    Molecular and Cellular Unit, School of Health Sciences, Universitat Internacional de Catalunya, Josep Trueta s n, Sant Cugat del Vallès, Barcelona 08195, Spain
    J Biol Chem 283:6878-85. 2008
    ..13 nmol.mg(-1).min(-1), respectively, which is approximately 50% higher than endogenous CPT1 activity. Kinetic studies demonstrate that CPT1c has similar affinity to CPT1a for both substrates but 20-300 times lower catalytic efficiency.
  32. pmc Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine
    A L Henneberry
    Atlantic Research Centre, Departments of Pediatrics and Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Biochem J 339:291-8. 1999
    ..cells devoid of endogenous cholinephosphotransferase or ethanolaminephosphotransferase activities (HJ091, cpt1::LEU2 ept1-)...
  33. ncbi Turnover of phosphatidylcholine in Saccharomyces cerevisiae. The role of the CDP-choline pathway
    S R Dowd
    Departments of Biological Sciences and Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    J Biol Chem 276:3756-63. 2001
    ..the genes encoding enzymes of the CDP-choline pathway for phosphatidylcholine biosynthesis (CKI1, choline kinase; CPT1, 1, 2-diacylglycerol choline phosphotransferase; PCT1, CTP:phosphocholine cytidylyltransferase), no induction of ..
  34. pmc Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
    Pawel Dobrzyn
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 101:6409-14. 2004
    ..Lower malonyl-CoA concentrations are known to derepress carnitine palmitoyltransferase 1 (CPT1). In SCD1-/- mice, CPT1 and CPT2 activities were significantly increased (in both cases approximately 60%, P < 0...
  35. pmc Cytoplasmic accumulation of long-chain coenzyme A esters activates KATP and inhibits Kir2.1 channels
    Ekaterina Shumilina
    Institute of Physiology II, Friedrich Schiller University, Jena, Teichgraben 8, 07743 Jena, Germany
    J Physiol 575:433-42. 2006
    ..promote the accumulation of LC-CoA by inhibiting their mitochondrial uptake via carnitine-palmitoyl-transferase-1 (CPT1)...
  36. doi Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice
    Hong Jen Liang
    Department of Food Science, Yuanpei University, Hsinchu, Taiwan
    Chem Biol Interact 181:309-15. 2009
    ..These results suggest that osthole can alleviate hyperglycemia and could be potentially developed into a novel drug for treatment of diabetes mellitus...
  37. ncbi Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats
    C Cruciani-Guglielmacci
    Laboratory of the Physiopathology of Nutrition, Universite Paris 7, CNRS UMR 7059, 2, place Jussieu, case 7126, 75251 Paris Cedex 05, France
    Diabetologia 47:2032-8. 2004
    ..We hypothesised that cerebral NEFA beta oxidation is a prerequisite for these central effects...
  38. ncbi PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure
    Beat M Jucker
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, and Genomics Research, GlaxoSmithKline, King of Prussia, PA 19406, USA
    J Cardiovasc Pharmacol 50:25-34. 2007
    ..metabolic changes were associated with an increase in lipid transport/metabolism target gene expression (eg, CD36, CPT1, UCP3)...
  39. doi Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short- and medium-term fasting and refeeding
    Mariona Palou
    Molecular Biology, Nutrition and Biotechnology Nutrigenomics, University of the Balearic Islands UIB, Palma de Mallorca 07122, Spain
    J Nutr Biochem 21:23-33. 2010
    ..It is suggested that different regulations of the expression of genes related with lipid metabolism between internal and subcutaneous depots to feeding and fasting conditions are site-specific metabolic features of white adipose tissue...
  40. doi Regulation of fatty acid oxidation in chicken (Gallus gallus): interactions between genotype and diet composition
    A Collin
    INRA, UR83 Recherches Avicoles, F 37380 Nouzilly, France
    Comp Biochem Physiol B Biochem Mol Biol 153:171-7. 2009
    ..Muscle expressions of the muscle isoform of carnitine-palmitoyltransferase 1 (M-CPT1) and PPARbeta/delta were higher in fat than in lean chickens...
  41. ncbi Hepatic carnitine palmitoyl transferase 1 (CPT1 A) deficiency in North American Hutterites (Canadian and American): evidence for a founder effect and results of a pilot study on a DNA-based newborn screening program
    C Prasad
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3A 1S1
    Mol Genet Metab 73:55-63. 2001
    We describe six patients with hepatic carnitine palmitoyl transferase (CPT1 A) deficiency who are members of a large extended Hutterite kindred living in widely scattered communities in the United States and Canadian Prairies...
  42. doi Dexamethasone facilitates lipid accumulation and mild feed restriction improves fatty acids oxidation in skeletal muscle of broiler chicks (Gallus gallus domesticus)
    Xiaojuan Wang
    Department of Animal Science, Shandong Agricultural University, Taian, Shandong 271018, PR China
    Comp Biochem Physiol C Toxicol Pharmacol 151:447-54. 2010
    ..Compared with the control, liver-carnitine palmitoyltransferase 1 (L-CPT1) and AMP-activated protein kinase (AMPK) alpha2 mRNA level of M...
  43. doi Effects of atypical antipsychotics and haloperidol on PC12 cells: only aripiprazole phosphorylates AMP-activated protein kinase
    Goro Takami
    Department of Physiology, School of Medicine, Fujita Health University, Toyoake 470 1192, Japan
    J Neural Transm (Vienna) 117:1139-53. 2010
    ..Therefore, although this study did not differentiate orexigenic and non-orexigenic AAPs, it suggests that aripiprazole is unique in its ability to activate AMPK...
  44. pmc Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues
    Nigel T Price
    Warwick Medical School, University of Warwick, Gibbett Hill Road, Coventry CV4 7AL, United Kingdom
    J Biol Chem 285:7857-65. 2010
    ..amino acid residues that are known to be essential for the binding of substrates and of malonyl-CoA in mammalian CPT1A. We performed PCR analyses of mRNA from different Drosophila tissues; both of the anticipated splice variants of ..
  45. doi Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids
    M Bionaz
    Department of Animal Sciences, Penn State University, University Park, PA 16801, USA
    J Dairy Sci 91:2808-13. 2008
    ..The gene expression of specific PPARalpha-responsive genes such as carnitine palmitoyl transferase-1 (CPT1A) and acetyl coenzyme A oxidase (ACOX1) and of PPARgamma-responsive gene lipoprotein lipase (LPL) were analyzed ..
  46. doi Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
    X F Gao
    Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China
    Diabetologia 52:912-20. 2009
    Carnitine palmitoyltransferase-1 (CPT1)c is a novel isoform in the CPT1 family and is found specifically in the brain. Cpt1c knockout (KO) mice are more susceptible to high-fat diet (HFD)-induced obesity...
  47. doi Ghrelin-mediated appetite regulation in the central nervous system
    Katarzyna Kirsz
    Department of Swine and Small Ruminant Breeding, Laboratory of Genomics and Biotechnology, University of Agriculture, Krakow 30 059, Poland
    Peptides 32:2256-64. 2011
    ..it plays a key role in the metabolic changes of lipids, mainly those involving hypothalamic NOS, AMPK, CaMKK2, CPT1 and UCP2 proteins...
  48. doi The effect of clozapine on the AMPK-ACC-CPT1 pathway in the rat frontal cortex
    Min Kyung Kim
    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea
    Int J Neuropsychopharmacol 15:907-17. 2012
    ..metabolism through modulating the downstream acetyl CoA carboxylase (ACC) and carnitine palmitoyl transferase 1 (CPT1) pathway...
  49. ncbi Several statins increase body and liver fat accumulation in a model of metabolic syndrome
    L Aguirre
    Nutrition and Obesity Group, Department of Nutrition and Food Sciences, University of Pais Vasco UPV EHU, Vitoria, Spain
    J Physiol Pharmacol 64:281-8. 2013
    ..These results show that statins have different effects on body fat accumulation. Moreover, rosuvastatin also shows a prosteatotic effect. These results should be taken into account for statin choice in prescription. ..
  50. pmc High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism
    Alessandra Cirillo
    Institute of Biomedicine and Bioresources CNR Naples, Italy
    Cancer Biol Ther 15:735-41. 2014
    ..We measured the mRNA levels of ZFP57, TRIM28, CPT1A, CPT1B, and CPT1C in a cohort of 80 patients divided in two groups: grade II and grade IV...
  51. doi Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring
    R O Benatti
    Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas UNICAMP, Rua Pedro Zaccaria, 1300 Jardim Santa Luiza, Limeira, Sao Paulo, CEP 13484350, Brazil
    Br J Nutr 111:2112-22. 2014
    ..Interestingly, mRNA expression levels of the β-oxidation-related genes ACADVL and CPT1 were decreased in HFD-O mice (P< 0·05)...
  52. pmc Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
    Ellen W Demerath
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
    Hum Mol Genet 24:4464-79. 2015
    ..for significance in ARIC (P < 1 × 10(-7); Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe...
  53. pmc Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle
    Blake B Rasmussen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Clin Invest 110:1687-93. 2002
    ..07 nmol/g during hyperglycemia with hyperinsulinemia. We conclude that hyperglycemia with hyperinsulinemia increases malonyl-CoA, inhibits functional CPT-1 activity, and shunts LCFA away from oxidation and toward storage in human muscle...
  54. ncbi AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
    Barbara B Kahn
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 1:15-25. 2005
    ..Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes...
  55. ncbi Structural principles of the wide substrate specificity of Thermoactinomyces vulgaris carboxypeptidase T. Reconstruction of the carboxypeptidase B primary specificity pocket
    V Kh Akparov
    Stepanov Laboratory of Protein Chemistry, Institute of Genetics and Selection of Industrial Microorganisms, 1 yi Dorozhnyi Proezd 1, 117545 Moscow, Russia
    Biochemistry (Mosc) 72:416-23. 2007
    ..which is capable of hydrolyzing both hydrophobic and positively charged substrates, resulted in five mutants: CpT1 (A243G), CpT2 (D253G/T255D), CpT3 (A243G/D253G/T255D), CpT4 (G207S/A243G/D253G/T255D), and CpT5 (G207S/A243G/T250A/..
  56. doi A combination of CLA-DAG oil modifies the diabetic phenotype in male Zucker diabetic fatty rats
    M J Iqbal
    Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, Illinois, USA
    Horm Metab Res 40:262-8. 2008
    ..We also observed changes in transcript abundance of PPAR-gamma, PPAR-alpha, FAS, LPL, UCP2, UCP3, CPT1, RxR, ObRb, ApoAII, ApoD, and IRS1 in liver, muscle, and adipose tissue, suggesting treatment-induced effects on ..
  57. doi Impaired adiponectin-AMPK signalling in insulin-sensitive tissues of hypertensive rats
    Amaia Rodríguez
    Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Life Sci 83:540-9. 2008
    ..Adiponectin improves insulin sensitivity by decreasing lipid accumulation in insulin-sensitive tissues. The aim of this study was to investigate whether these effects are altered in hypertension...
  58. ncbi The effects of BADGE and caffeine on the time-course response of adiponectin and lipid oxidative enzymes in high fat diet-fed C57BL/6J mice: correlation with reduced adiposity and steatosis
    Jun Won Yun
    AmorePacific Corporation R and D Center, Daegu, Korea
    Exp Anim 57:461-9. 2008
    ..ACC phosphorylation and carnitine palmitoyl-transferase-1 (CPT1) activity have been shown to be rate controlling factors in fatty acid oxidation...
  59. pmc Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination
    Phillip L Butler
    Department of Biochemistry, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 285:6246-58. 2010
    ..Overexpression of LPCAT1 increased degradation of CPT1 (cholinephosphotransferase), a resident Golgi enzyme that catalyzes the terminal step for de novo PtdCho synthesis...
  60. pmc Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex
    Kwangwon Lee
    Center for Mitochondrial Diseases, Cleveland, Ohio 44106 4981, USA
    J Biol Chem 286:25655-62. 2011
    b>CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial outer membrane (MOM) catalyzes the primary regulated step in overall mitochondrial fatty acid oxidation...
  61. doi Leanness of Lou/C rats does not require higher thermogenic capacity of brown adipose tissue
    Maud Belouze
    Laboratoire de Physiologie, Universite de Lyon, CNRS, 43 Bvd 11 Novembre 1918, F 69622 Villeurbanne Cedex, France
    Physiol Behav 104:893-9. 2011
    ..Relative abundance of β3-adrenergic receptor mRNA was lower in Lou/C BAT while that of GLUT4, FABP or CPT1 was not altered...
  62. doi Erythropoietin administration acutely stimulates resting energy expenditure in healthy young men
    Britt Christensen
    Department of Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    J Appl Physiol (1985) 112:1114-21. 2012
    ..in the basal state tended to be higher after rHuEpo but could not be explained by changes in mRNA levels of CPT1 and PPARα or AMPK and ACC protein phosphorylation...
  63. doi Inhibitory effect of Ginkgo biloba extract on fatty liver: regulation of carnitine palmitoyltransferase 1a and fatty acid metabolism
    Shi Dong Wang
    Center for Chinese Medical Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    J Dig Dis 13:525-35. 2012
    ..To investigate the potential effect of Ginkgo biloba extract (GBE) on the prevention and treatment of nonalcoholic fatty liver disease (NAFLD)...
  64. doi Carnitine palmitoyltransferase I and sudden unexpected infant death in British Columbia First Nations
    Graham B Sinclair
    Departmens of aPathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia
    Pediatrics 130:e1162-9. 2012
    ..The p.P479L (c.1436C>T) variant of carnitine palmitoyltransferase 1 (CPT1A) is frequent in some aboriginal populations and may be associated with increased infant deaths...
  65. pmc Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni
    Stanley Ching Cheng Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 8:e1002996. 2012
    ..and egg production are significantly diminished by pharmacologic inhibition of carnitine palmitoyl transferase 1 (CPT1), which catalyzes a rate limiting step in fatty acid β-oxidation (FAO) and by genetic loss of function of acyl CoA ..
  66. doi Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1 (Srebf1) and activation of peroxisome proliferator activated recep
    Li juan Shi
    Department of Endocrinology, The Third Hospital of Shijiazhuang City Affiliated to Hebei Medical University, Shijiazhuang 050011, China
    Eur J Pharmacol 714:89-95. 2013
    ..decreased the fatty acid synthase (FAS) enzymatic activity and increased the carnitine palmitoyltransferase 1A (CPT1A) enzymatic activity...
  67. pmc Fatty acid transporter CD36 mediates hypothalamic effect of fatty acids on food intake in rats
    Valentine S Moullé
    Unit of Functional and Adaptive Biology, EAC 4413 CNRS, Universite Paris Diderot, Paris, France
    PLoS ONE 8:e74021. 2013
    ..1) Rats previously injected in ventromedian nucleus (VMN) with shRNA against CD36 or scrambled RNA; 2) Etomoxir (CPT1 inhibitor) or saline co-infused with IL(H)/S(H); and 3) Triacsin C (acylCoA synthase inhibitor) or saline co-..
  68. doi Differential effect of waterborne cadmium exposure on lipid metabolism in liver and muscle of yellow catfish Pelteobagrus fulvidraco
    Qi Liang Chen
    Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture of P R C, Fishery College, Huazhong Agricultural University, Wuhan 430070, China Freshwater Aquaculture Collaborative Innovative Centre of Hubei Province, Wuhan 430070, China
    Aquat Toxicol 142:380-6. 2013
    ..Carnitine palmitoyltransferase 1 (CPT1) activity as well as the mRNA expressions of CPT1 and PPARγ showed no significant differences among the treatments...
  69. doi Expression of adipokine and lipid metabolism genes in adipose tissue of dairy cows differing in a female fertility quantitative trait locus
    Sebastien Elis
    INRA, UMR85 Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France CNRS, UMR 7247 Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France Université François Rabelais de Tours, UMR Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France IFCE, UMR Physiologie de la Reproduction et des Comportements, F 37380 Nouzilly, France Electronic address
    J Dairy Sci 96:7591-602. 2013
    ..of genes that were overexpressed during mobilization (ADIPOQ, ADIPOR2, LIPE, FABP4, PLIN1, RARRES, LEPR, and CPT1A) and cluster 2 of genes overexpressed during reconstitution of body reserves (ACACA, FASN, and SCD)...
  70. doi Long-term intake of soyabean phytosterols lowers serum TAG and NEFA concentrations, increases bile acid synthesis and protects against fatty liver development in dyslipidaemic hamsters
    Sirle Laos
    Centre Tecnològic de Nutrició i Salut CTNS, TECNIO, CEICS, Avinguda Universitat 1, 43204Reus, Tarragona, Spain
    Br J Nutr 112:663-73. 2014
    ..the expression of key genes related to fatty acid oxidation such as PPARA, carnitine palmitoyltransferase-Iα (CPT1A) and phosphoenolpyruvate carboxykinase 1 (PCK1) in the liver...
  71. doi Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes
    Ming Zhao
    Department of Food Science and Nutrition, University of Minnesota Twin Cities, Saint Paul, MN 55108, United States
    Biochem Biophys Res Commun 450:1446-51. 2014
    ..Consistently, long-term EPA treatment also upregulated AMPKα phosphorylation and CPT1 expression and increased glucose uptake and GLUT4 mRNA expression, suggesting improved mitochondrial oxidation...
  72. doi Supplementation of Vitis thunbergii root extract alleviated high-fat diet-induced obesity in C57BL/6J mice
    Hong Ming Hsu
    a Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan
    Biosci Biotechnol Biochem 78:867-73. 2014
    ..Mechanistic study showed that VTE supplementation increased energy expenditure-related CPT1 mRNA expression and AMPK phosphorylation, and decreased lipogenesis-related SREBP-1 expression in liver...
  73. pmc An integrated genomics approach identifies drivers of proliferation in luminal-subtype human breast cancer
    Michael L Gatza
    1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 2 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Genet 46:1051-9. 2014
    ..The genes identified include eight that are essential for cell proliferation (FGD5, METTL6, CPT1A, DTX3, MRPS23, EIF2S2, EIF6 and SLC2A10) and are uniquely amplified in patients with highly proliferative luminal ..
  74. doi Fatty acid chain length and saturation influences PPARα transcriptional activation and repression in HepG2 cells
    Herman E Popeijus
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands
    Mol Nutr Food Res 58:2342-9. 2014
    ..Secretion of apoA-I protein as well as CPT1, ACO, and PPARα mRNA expression, all accepted PPARα targets, were determined as read-outs.
  75. pmc DNA methylation signatures link prenatal famine exposure to growth and metabolism
    Elmar W Tobi
    Molecular Epidemiology, Leiden University Medical Center, 2300RC Leiden, The Netherlands
    Nat Commun 5:5592. 2014
    ..P-DMRs located in INSR and CPT1A have enhancer activity in vitro and differential methylation is associated with birth weight and serum LDL ..
  76. pmc A lettuce (Lactuca sativa) homolog of human Nogo-B receptor interacts with cis-prenyltransferase and is necessary for natural rubber biosynthesis
    Yang Qu
    From the Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    J Biol Chem 290:1898-914. 2015
    ..Intriguingly, a homologous pair CPTL1/CPT1, which displays ubiquitous expressions in lettuce, showed a potent dolichol biosynthetic activity in vitro...
  77. pmc Fatty acid carbon is essential for dNTP synthesis in endothelial cells
    Sandra Schoors
    1 Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, B 3000 Leuven, Belgium 2 Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, B 3000 Leuven, Belgium
    Nature 520:192-7. 2015
    ..Here we report that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired ..
  78. pmc Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference
    Stella Aslibekyan
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Obesity (Silver Spring) 23:1493-501. 2015
    ..To conduct an epigenome-wide analysis of DNA methylation and obesity traits...
  79. doi Effects of sleeping with reduced carbohydrate availability on acute training responses
    Stephen C Lane
    Exercise and Nutrition Research Group, School of Medical Sciences, RMIT University, Bundoora, Australia
    J Appl Physiol (1985) 119:643-55. 2015
    ..05). Fat oxidation during 120SS was higher in FASTED (P = 0.01), coinciding with increases in ACC(Ser79) and CPT1 as well as mRNA expression of CD36 and FABP3 (P < 0.05)...
  80. pmc Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice
    Mei Xue
    Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, Xiamen, People s Republic of China Department of Pharmacology, Beijing University of Chinese Medicine, Chao Yang District, Beijing, People s Republic of China
    Int J Nanomedicine 10:5049-57. 2015
    ..element-binding protein 1c (SREBP1c) were downregulated, while lipolytic gene carnitine palmitoyltransferase-1 (CPT1) was upregulated in BBR-SLN-treated livers...
  81. pmc Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis
    Hong Wang
    Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, Chin
    Sci Rep 5:15019. 2015
    ..The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of ..
  82. pmc 3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats
    Daniel F Vatner
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, United States of America
    PLoS ONE 10:e0140837. 2015
    ..Further study will be necessary before diiodothyronines can be considered an effective treatment for NAFLD and dyslipidemia. ..
  83. doi Effects of bisphenol A on lipid metabolism in rare minnow Gobiocypris rarus
    Yongjing Guan
    College of Animal Science and Technology, Northwest A and F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China
    Comp Biochem Physiol C Toxicol Pharmacol 179:144-9. 2016
    ..serum, the activities of acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), carnitine palmitoyltransferase (CPT1), and glycerol-3-phosphate acyltransferase (GPAT) enzymes and the mRNA expression of acaca, acacb, fasn, gpat1 and ..
  84. doi Effects of Selenium-Enriched Probiotics on Lipid Metabolism, Antioxidative Status, Histopathological Lesions, and Related Gene Expression in Mice Fed a High-Fat Diet
    Sonia Agostinho Nido
    Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowl, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China
    Biol Trace Elem Res 171:399-409. 2016
    ..Generally, adding P, SS, or SP up-regulated mRNA expression of carnitine palmitoyltransferase-I (CPT1), carnitine palmitoyltransferase II (CPT2), acetyl-CoA acetyltransferase II (ACAT2), acyl-coenzyme A oxidase (ACOX2)..
  85. doi Carnitine palmitoyltransferase 1C: From cognition to cancer
    Nuria Casals
    CIBER Fisiopatología de la Obesidad y la Nutrición CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, E 08195 Sant Cugat del Vallès, Barcelona, Spain Electronic address
    Prog Lipid Res 61:134-48. 2016
    Carnitine palmitoyltransferase 1 (CPT1) C was the last member of the CPT1 family of genes to be discovered. CPT1A and CPT1B were identified as the gate-keeper enzymes for the entry of long-chain fatty acids (as carnitine esters) into ..
  86. pmc Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study
    Mithun Das
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States of America
    PLoS ONE 11:e0145789. 2016
    ..A Bonferroni-corrected P-value of 1.1 x 10(-7) was considered significant. Methylation at two CpG sites in CPT1A on chromosome 11 was significantly associated with MetS (P for cg00574958 = 2.6x10(-14) and P for cg17058475 = 1...
  87. pmc Looking at the metabolic consequences of the colchicine-based in vivo autophagic flux assay
    Iban Seiliez
    a INRA, UR1067 Nutrition Métabolisme Aquaculture, St Pée sur Nivelle, France
    Autophagy 12:343-56. 2016
    ..In contrast, transcript levels of β-oxidation-related gene Cpt1a dropped significantly...
  88. pmc Novel Mutations in the CPT1A Gene Identified in the Patient Presenting Jaundice as the First Manifestation of Carnitine Palmitoyltransferase 1A Deficiency
    Jong Sub Choi
    Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
    Pediatr Gastroenterol Hepatol Nutr 19:76-81. 2016
    Carnitine palmitoyltransferase 1A (CPT1A) is an enzyme functioning in mitochondrial fatty acid oxidation (FAO) of the liver...
  89. doi The intake of high-fat diets induces an obesogenic-like gene expression profile in peripheral blood mononuclear cells, which is reverted by dieting
    Bàrbara Reynés
    Laboratory of Molecular Biology, Nutrition and Biotechnology, Universitat de les Illes Balears and CIBER de Fisiopatología de la Obesidad y Nutrición CIBEROBN, E 07122 Palma de Mallorca, Spain
    Br J Nutr 115:1887-95. 2016
    ..Regulation of carnitine palmitoyltransferase I (Cpt1a) mRNA expression was of special interest; its expression reflected metabolic alterations related to the intake of ..
  90. doi The effect of increasing concentrations of dl-methionine and 2-hydroxy-4-(methylthio) butanoic acid on hepatic genes controlling methionine regeneration and gluconeogenesis
    Qian Zhang
    Department of Dairy Science, University of Wisconsin, Madison 53706
    J Dairy Sci 99:8451-60. 2016
    ..Neither dl-Met nor HMB altered the expression of carnitine palmitoyltransferase 1A(CPT1a)...
  91. ncbi sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products
    R H Hjelmstad
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 266:5094-103. 1991
    ..EPT1 gene product exhibited 54% amino acid sequence homology to the cholinephosphotransferase product of the yeast CPT1 gene...
  92. ncbi The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene
    R H Hjelmstad
    Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710
    J Biol Chem 265:1755-64. 1990
    The complete nucleotide sequence of the Saccharomyces cerevisiae CPT1 gene, a structural gene for the sn-1,2-diacylglycerol cholinephosphotransferase (Hjelmstad, R. H., and Bell, R. M. (1987) J. Biol. Chem. 262, 3909-3917), was determined...
  93. pmc Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity
    I Rousso
    Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 97:13523-5. 2000
    ..Our results strongly support the suggestion that HIV-1 buds from lipid rafts and point to a role for rafts as a viral assembly hub...
  94. ncbi Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats
    Heidrun Karlic
    Ludwig Boltzmann Institute for Leukemia Research and Hematology, Vienna, Austria
    J Histochem Cytochem 50:205-12. 2002
    ..was determined by quantitative reverse transcription real-time PCR (RTQPCR) and compared to the activity of the CPT1A enzyme...
  95. pmc Cloning and expression of the liver and muscle isoforms of ovine carnitine palmitoyltransferase 1: residues within the N-terminus of the muscle isoform influence the kinetic properties of the enzyme
    Nigel T Price
    Hannah Research Institute, Ayr KA6 5HL, UK
    Biochem J 372:871-9. 2003
    ..data reported will appear in DDBJ, EMBL, GenBank(R) and GSDB Nucleotide Sequence Databases; the sequences of ovine CPT1A and CPT1B cDNAs have the accession numbers Y18387 and AJ272435 respectively and the partial adipose tissue and ..
  96. ncbi Novel metabolic and molecular findings in hepatic carnitine palmitoyltransferase I deficiency
    Stanley H Korman
    Department of Clinical Biochemistry, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem 91120, Israel
    Mol Genet Metab 86:337-43. 2005
    ..This C12 dicarboxylic aciduria suggests that CPT I may play a role in uptake of long-chain dicarboxylic acids by mitochondria after their initial shortening by beta-..
  97. ncbi Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling
    Juan J Loor
    Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Physiol Genomics 27:29-41. 2006
    ..prepartum resulted in more pronounced upregulation of genes with key functions in hepatic fatty acid oxidation (CPT1A, ADIPOR2), gluconeogenesis (PC), and cholesterol synthesis (SC4MOL)...
  98. ncbi A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) stud
    Christian J F Holubarsch
    Department of Cardiology, Hospital Lazariterhof and Baden, Median Clinics Bad Krozingen, Bad Krozigen, Germany
    Clin Sci (Lond) 113:205-12. 2007
    Etomoxir is an inhibitor of mitochondrial CPT1 (carnitine palmitoyltransferase 1) and thereby switches energy metabolism from fatty acids to glucose oxidation. Such a metabolic change may be beneficial in CHF (congestive heart failure)...
  99. ncbi Rat liver carnitine palmitoyltransferase 1 forms an oligomeric complex within the outer mitochondrial membrane
    Audrey Faye
    Institut Cochin, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Paris Descartes, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 282:26908-16. 2007
    ..Located within the outer mitochondrial membrane, CPT1A activity is inhibited by malonyl-CoA, its allosteric inhibitor...
  100. pmc Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight
    Michael J Wolfgang
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 105:1550-9. 2008
    ..Malonyl-CoA functions as an inhibitor of carnitine palmitoyl-transferase 1 (CPT1), a mitochondrial outer membrane enzyme that initiates translocation of fatty acids into mitochondria for oxidation...
  101. doi Gene expression patterns in visceral and subcutaneous adipose depots in rats are linked to their morphologic features
    Mariona Palou
    University of the Balearic Islands, CIBER de Fisiopatología de la Obesidad y Nutrición, Palma de Mallorca, Spain
    Cell Physiol Biochem 24:547-56. 2009
    ..than in the mesenteric and inguinal depots, while the expression of fatty-acid oxidation-related genes (PPARalpha, CPT1) was lower in the retroperitoneal depot compared with the mesenteric and the inguinal depots...

Research Grants25

  1. THE CARNITINE TRANSPORTER IN HUMAN DISEASE
    Nicola Longo; Fiscal Year: 2010
    ....
  2. NMR OF MITOCHONDRIAL TRANSPORTERS IN CARDIAC HYPERTROPHY
    E Douglas Lewandowski; Fiscal Year: 2013
    ..effects on contractility;2) increased expression of the liver (L) isoform of carnitine palmitoyltransferase I (L-CPT1) in hypertrophied hearts that coincides with reduced fatty acid oxidation;3) large reductions in both content and ..
  3. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..MS/MS), which led to the identification of an unexpectedly high incidence of carnitine palmitoyltransferase 1A (CPT1A) deficiency, a rare disorder of fatty acid oxidation...
  4. Leigh Goedeke; Fiscal Year: 2014
    ..of fatty acid oxidation, including carnitine O-octaniltransferase (CROT), carnitine palmitoyltransferase 1A (CPT1a), and hydroxyacyl-CoA-dehydrogenase (HADHB)...
  5. Regulated Expression of Hypothalamic CPT1 Using Gutless Adenovirus
    Silvana Obici; Fiscal Year: 2010
    ..of fuel abundance because of its potent allosteric inhibition of the enzyme carnitine palmitoyltransferase 1 (CPT1), which controls the entry of fatty acids into mitochondria where they undergo oxidation...
  6. A MOUSE MODEL FOR HUMAN INHERITED DISEASES
    Philip A Wood; Fiscal Year: 2010
    ..The results of these studies could have wide ranging impact on understanding the underlying bases of many other inherited diseases. ..
  7. Carlos Fernandez Hernando; Fiscal Year: 2016
    ..For example, miR-33 targets carnitine O- octaniltransferase (CROT), Carnitine palmitoyltransferase 1A (CPT1a) and hydroxyacyl-CoA- dehydrogenase (HADHB), key enzymes involved in the regulation of fatty acid oxidation, and ..
  8. BRAIN SOCS3 AND PTP1B-ADIPOSE LEPTIN FEEDBACK AXIS IN ALCOHOLIC HEPATOSTEATOSIS
    Raj M Lakshman; Fiscal Year: 2011
    ..Simultaneously, the active ACC generates more malonyl CoA, a potent inhibitor of CPT1, the rate limiting enzyme of fatty acid oxidation pathway causing decreased lipid oxidation...
  9. Hypothalamic Fatty Acid Sensing in Aging
    Rachel Ross; Fiscal Year: 2010
    ..critical enzymes in fatty acid metabolism: malonyl-CoA decarboxylase (MOD) and carnitine palmitoyl transferase 1 (CPT1) and then examine their impact on the metabolic syndrome of aging in rats. I will pursue two experimental aims...
  10. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  11. Antiadipogenic Influence of HIV Protease Inhibitors
    M Lane; Fiscal Year: 2005
    ..The long term objective of the proposed research is to facilitate the design of anti-HIV therapeutics that lack lipoatrophic potential. ..
  12. Diet Therapy of Long-Chain Fatty Acid Oxidation Defects
    MELANIE GILLINGHAM; Fiscal Year: 2005
    ..abstract_text> ..
  13. FATTY ACID BINDING PROTEINS-LIGAND SPECIFICITY
    Friedhelm Schroeder; Fiscal Year: 2010
    ..Differences in this nuclear receptor/fatty acid energy regulation could contribute to the pathogenesis of obesity, insulin resistance, type 2 diabetes mellitus, and hyperlipidemic conditions. ..
  14. Metabolic enzyme activity mediating myocardial stunning
    E Lewandowski; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  15. ASYMMETRIC DISTRIBUTION OF CHOLESTEROL IN MEMBRANES
    Friedhelm Schroeder; Fiscal Year: 2010
    ..If this process were understood, new therapeutic targets for increasing cholesterol efflux for lowering plasma cholesterol could potentially be developed. ..
  16. FACTORS AND GENES RESPONSIBLE FOR ADIPOCYTE COMMITMENT
    M Lane; Fiscal Year: 2006
    ..abstract_text> ..
  17. The Genetics of Infant Growth and Later Obesity
    Ellen W Demerath; Fiscal Year: 2010
    ....
  18. PPARgamma signaling pathway in cardiac hypertrophy and failure
    Qinglin Yang; Fiscal Year: 2010
    ....
  19. REGULATION OF LIPOGENESIS
    M Lane; Fiscal Year: 2001
    ..for derepression and repression of the SCD1 and SCD2 genes. ..
  20. Anaplerotic therapy in Propionic Acidemia
    Nicola Longo; Fiscal Year: 2008
    ..This approach, if effective, could be extended to a number of other diseases, including other organic acidemias and mitochondrial disorders. [unreadable] [unreadable] [unreadable]..
  21. HORMONAL CONTROL OF ADIPOSE GENE EXPRESSION
    M Lane; Fiscal Year: 2007
    ..The 32kDa CUP/AP-2alpha- interacting protein, p32, previously identified in our lab, will be characterized and its role determined. ..
  22. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2006
    ....
  23. Protein Tyrosine Phosphatase 1B and Insulin Action
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to reduce insulin resistance and prevent or ameliorate type 2 diabetes. ..
  24. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara Kahn; Fiscal Year: 2005
    ..Our goal is to find new therapeutic targets to prevent or ameliorate type 2 diabetes. ..
  25. FASEB Research Conf: Glucose Transporter Biology
    Barbara Kahn; Fiscal Year: 2003
    ..abstract_text> ..