Genomes and Genes
Gene Symbol: COLQ
Description: collagen like tail subunit of asymmetric acetylcholinesterase
Alias: CMS5, EAD, acetylcholinesterase collagenic tail peptide, AChE Q subunit, acetylcholinesterase-associated collagen, collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase, collagenic tail of endplate acetylcholinesterase, single strand of homotrimeric collagen-like tail subunit of asymmetric acetylcholinesterase
Publications203 found, 100 shown here
- [Epidemiological studies on enteric adenovirus gastroenteritis in children]Y Yamashita
Ehime Prefectural Institute of Public Health
Kansenshogaku Zasshi 69:377-82. 1995Enteric adenoviruses (EAd), adenovirus (Ad) types 40 and 41, have been established as causative agents of gastroenteritis...
- Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzymeK Ohno
Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
Proc Natl Acad Sci U S A 95:9654-9. 1998..ACHET) and heteromeric asymmetric forms composed of 1, 2, or 3 tetrameric ACHET attached to a collagenic tail (ColQ). Asymmetric AChE is concentrated at the endplate (EP), where its collagenic tail anchors it into the basal lamina...
- Mutation in the human acetylcholinesterase-associated collagen gene, COLQ, is responsible for congenital myasthenic syndrome with end-plate acetylcholinesterase deficiency (Type Ic)C Donger
INSERM U153, Group Hospitalier Pitie Salpetriere, France
Am J Hum Genet 63:967-75. 1998..which is normally concentrated at NMJs, is composed of catalytic tetramers associated with a specific collagen, COLQ. In CMS-Ic patients, these collagen-tailed forms are often absent...
- [Enzyme-linked immunosorbent assay using monoclonal antibodies for direct serotyping of enteric adenoviruses in feces]K Takagi
Department of Microbiology, Ehime Prefectural Institute of Public Health
Kansenshogaku Zasshi 65:552-8. 1991..For identification of enteric adenoviruses (EAd) in stool specimens, enzyme-linked immunosorbent assay (ELISA) test using monoclonal antibodies was developed...
- Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletionShelley Camp
University of California, San Diego, 9500 Gilman Dr, Department of Pharmacology, La Jolla, CA 92093 0636, USA
Chem Biol Interact 157:79-86. 2005..system, whereas the splice to exon 6 produces a sequence that binds to the structural subunits PRiMA and ColQ, producing AChE expression in brain and muscle...
- The C-terminal peptides of acetylcholinesterase: cellular trafficking, oligomerization and functional anchoringJean Massoulié
Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UMR 8544, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
Chem Biol Interact 157:3-14. 2005..wide variety of oligomeric forms, ranging from monomers to heteromeric assemblies containing the anchoring proteins ColQ (collagen-tailed forms) and PRiMA (membrane-bound tetramers), which constitute the major functional enzyme species ..
- Early afterdepolarizations and arrhythmogenesis. Experimental and clinical aspectsN El-Sherif
Cardiology Division, State University of New York Health Science Center, Brooklyn 11203
Arch Mal Coeur Vaiss 84:227-34. 1991There is growing evidence that early afterdepolarizations (EADs) and EAD-induced triggered activity play a significant role in the clinical syndrome of long QTU and polymorphic ventricular tachyarrhythmias better known as Torsade de ..
- Reciprocal neural regulation of extrajunctional acetylcholinesterase and collagen Q in rat muscles--the role of calcineurin signalingMiha Trinkaus
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 175:45-9. 2008..The latter is due to the absence of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
- Olfactory responses of Ips duplicatus from inner Mongolia, China to nonhost leaf and bark volatilesQ H Zhang
Department of Crop Science, Swedish University of Agricultural Sciences, Alnarp
J Chem Ecol 27:995-1009. 2001..nonhost angiosperm trees were tested on Ips duplicatus by gas chromatographic-electroantennographic detection (GC-EAD) and by pheromone-baited traps in Sweden and Inner Mongolia, China, respectively...
- Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesteraseEmmanuelle Girard
Laboratoire de Neurobiologie Cellulaire et Moleculaire, UPR 9040, CNRS, 91198 Gif sur Yvette Cedex, France
J Mol Neurosci 30:99-100. 2006..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins ColQ (Krejci et al., 1997) and PRiMA (Perrier et al., 2002)...
- Behavioral and electrophysiological responses of Triatoma brasiliensis males to volatiles produced in the metasternal glands of femalesAna C R Vitta
Laboratório de Triatomíneos e Epidemiologia da Doença de Chagas, Centro de Pesquisas Rene Rachou Fiocruz, 30 190 002, Belo Horizonte, Minas Gerais, Brazil
J Chem Ecol 35:1212-21. 2009..In addition, GC-EAD recordings showed that the antennae of males responded to several of the main components of female MG secretions...
- Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in miceN Ibnou-Zekri
Department of Pathology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
Proc Natl Acad Sci U S A 94:14654-9. 1997..that (i) the development of SLE was almost completely prevented in BXSB (H-2(b)) mice expressing two copies of the Ead transgene at the homozygous level as well as in BXSB H-2(k) (I-E+) congenic mice as for H-2(d) BXSB mice, and (ii) ..
- Electroantennographic and behavioral responses of the sphinx moth Manduca sexta to host plant headspace volatilesAnn M Fraser
ARL Division of Neurobiology, University of Arizona, P O Box 210077, Tucson, Arizona 85721 0077, USA
J Chem Ecol 29:1813-33. 2003Coupled gas chromatography with electroantennographic detection (GC-EAD) using antennae of adult female Manduca sexta was employed to screen for olfactory stimulants present in headspace collections from four species of larval host ..
- Aerosol probes of emphysema progression in dogs treated with all trans retinoic acid--an exploratory studyFrank S Rosenthal
School of Health Sciences, Purdue University, 500 Stadium Mall Drive, West Lafayette, IN 47907, USA
J Aerosol Med 20:83-96. 2007..5/FVC), an aerosol-derived measure of pulmonary airspace size (effective airspace diameter, EAD), and an aerosol-derived measure of nonuniform ventilation (aerosol dispersion, AD)...
- The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibersDavid Fedida
Cardiome Pharma Corporation, University of British Columbia, Vancouver, BC, Canada
J Cardiovasc Electrophysiol 17:S71-S78. 2006..of lidocaine, mexiletine, and RSD1235 may result, at least in part, from their ability to inhibit late I(Na) during action potential repolarization, and inhibition of the inward currents contributing to EAD and arrhythmia formation.
- The asymmetric molecular forms of AChE and the expression of collagen Q in mature and immature fast and slow rat musclesSpela Glisović
Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia
Chem Biol Interact 187:90-5. 2010..The latter is due to the nearly complete suppression of the expression of AChE-associated collagen Q (ColQ) in the extrajunctional regions of fast muscle fibers, in contrast to its ample expression in slow muscles...
- Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalisS Sicouri
Masonic Medical Research Laboratory, Utica, New York 13504
J Cardiovasc Electrophysiol 4:48-58. 1993..Epicardial, M region, and endocardial tissues and cells show distinct, sometimes opposite, responses to a variety of drugs, including those capable of inducing EADs and DADs...
- Volatile emissions from Aesculus hippocastanum induced by mining of larval stages of Cameraria ohridella influence oviposition by conspecific femalesA Bettina Johne
Institute for Forest Zoology and Forest Conservation, Georg August University, Buesgenweg 3, 37077, Goettingen, Germany
J Chem Ecol 32:2303-19. 2006..Utilizing gas chromatography coupled with parallel detection by mass spectrometry and electroantennography (GC-MS/EAD), more than 30 compounds eliciting responses from antennae of C. ohridella were detected...
- Comparison of the in vitro electrophysiologic and proarrhythmic effects of amiodarone and sotalol in a rabbit model of acute atrioventricular blockPeter Milberg
Hospital of the Westfälische Wilhelms University, Department of Cardiology and Angiology and Institute for Arteriosclerosis Research, Munster, Germany
J Cardiovasc Pharmacol 44:278-86. 2004..01), but not in amiodarone-treated hearts (10%; p = ns). Sotalol led to early afterdepolarizations (EAD) and torsade de pointes (TdP) after lowering of potassium concentration (6 of 13 hearts)...
- Evolution of reproductive strategies in the sexually deceptive orchid Ophrys sphegodes: how does flower-specific variation of odor signals influence reproductive success?M Ayasse
Institute of Zoology, University of Vienna, Austria
Evolution 54:1995-2006. 2000..active in male olfactory receptors based on gas chromatography with electroantennographic detection (GC-EAD)...
- The origin of the molecular diversity and functional anchoring of cholinesterasesJean Massoulié
CNRS UMR 8544, Laboratoire de Neurobiologie, Ecole Normale Superieure, Paris, France
Neurosignals 11:130-43. 2002..homomeric oligomers (monomers, dimers, tetramers), as well as hetero-oligomeric assemblies with anchoring proteins, ColQ and PRiMA...
- Identification (GC and GC-MS) of unsaturated acetates in Elasmopalpus lignosellus and their biological activity (GC-EAD and EAG)Gulab N Jham
Departamento de Quimica, Universidade Federal de Vicosa, Vicosa, MG, Brazil
J Sep Sci 28:281-5. 2005..Extract 2 was analyzed by gas chromatography (GC) and gas chromatography-electroannetography (GC-EAD) revealing the presence of (Z)-11-HDA and (Z)-9-TDA. In addition, the same compounds elicited a response with the E...
- [Organ changes induced by ergot derivative dopamine agonist drugs: time to change treatment guidelines in Parkinson's disease?]J Roth
Centrum extrapyramidových onemocneni, Neurologická klinika 1 LF UK a VFN, Praha
Cas Lek Cesk 144:123-6. 2005..Not to use EAD as the first-line dopamine agonists. B...
- Electrophysiological and behavioral responses of Ips duplicatus to aggregation pheromone in Inner Mongolia, China: amitinol as a potential pheromone componentQing He Zhang
Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, 230 53 Alnarp, Sweden
J Chem Ecol 33:1303-15. 2007..gas chromatography-mass spectrometry (GC-MS), coupled gas chromatography-electroantennographic detection (GC-EAD), and field trapping bioassays in Inner Mongolia, China...
- [The effects of calmodulin kinase II inhibitor on ventricular arrhythmias in rabbits with cardiac hypertrophy]Jun Ke
Department of Cardiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Zhonghua Xin Xue Guan Bing Za Zhi 35:33-6. 2007..To investigate the effect of KN-93, a calmodulin kinase II inhibitor, on ventricular arrhythmias in rabbits with cardiac hypertrophy...
- Electrophysiological and behavioral responses of Ips subelongatus to semiochemicals from its hosts, non-hosts, and conspecifics in ChinaQing He Zhang
Chemical Ecology, Swedish University of Agricultural Sciences, P O Box 44, SE 230 53, Alnarp, Sweden
J Chem Ecol 33:391-404. 2007..were analyzed using both gas chromatographic-electroantennographic detection (GC-EAD) and gas chromatography/mass spectrometry (GC-MS) techniques, and field trapping bioassays in Inner Mongolia, China...
- Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixturesJeroen Kool
LACDR Division of Molecular Toxicology, Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands
J Biomol Screen 12:396-405. 2007A high-resolution screening (HRS) technology is described, which couples 2 parallel enzyme affinity detection (EAD) systems for substrates and inhibitors of rat cytosolic glutathione-S-transferases (cGSTs) and purified human GST P1 to ..
- General food semiochemicals attract omnivorous German cockroaches, Blattella germanicaNooshin Karimifar
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
J Agric Food Chem 59:1330-7. 2011..Coupled gas chromatographic-electroantennographic detection (GC-EAD) and GC-mass spectrometric (MS) analyses of these attractive extracts, or fractions thereof, and of synthetic ..
- Reverse and conventional chemical ecology approaches for the development of oviposition attractants for Culex mosquitoesWalter S Leal
Honorary Maeda Duffey Laboratory, Department of Entomology, University of California Davis, Davis, California, United States of America
PLoS ONE 3:e3045. 2008..both CquiOBP1 as a molecular target in binding assays and gas chromatography-electroantennographic detection (GC-EAD), we identified nonanal, trimethylamine (TMA), and skatole as test compounds...
- Aphrodisiac pheromones from the wings of the small cabbage white and large cabbage white butterflies, Pieris rapae and Pieris brassicaeSelma Yildizhan
Institut fur Organische Chemie, Technische Universitat Braunschweig, Hagenring 30, Braunschweig, Germany
Chembiochem 10:1666-77. 2009..activity of the compounds in the extract was tested by coupled gas chromatographic-electroantennographic (GC-EAD) analysis, which showed that both macrolides and the other major components of the wings can be detected by the ..
- Prioritizing environmental health risks in the UAEHenry H Willis
RAND Corporation, Pittsburgh, PA 15213, USA
Risk Anal 30:1842-56. 2010..in the United Arab Emirates (UAE) to inform a strategic planning process led by the Environment Agency-Abu Dhabi (EAD)...
- Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and functionG Feng
Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
J Cell Biol 144:1349-60. 1999..AChE) occurs in both asymmetric forms, covalently associated with a collagenous subunit called Q (ColQ), and globular forms that may be either soluble or membrane associated...
- Volatile attractants for the common bluebottle, Graphium sarpedon nipponum, from the host, Cinnamomum camphoraJing Li
Department of Agriculture, Faculty of Agriculture, Kochi University, Monobe, Nankoku, Japan
Biosci Biotechnol Biochem 74:1987-90. 2010..The volatiles were analyzed by capillary gas chromatography with electro-antennographic detection (GC-EAD)...
- Autoimmunity against the second extracellular loop of beta(1)-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbitsYukiko Fukuda
Cardiopulmonary Division of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
J Am Coll Cardiol 43:1090-100. 2004..We sought to define the electrophysiologic property of the rabbit heart associated with autoimmunity against the second extracellular loop of the beta(1)-adrenergic receptor...
- Atopic dermatitis, extrinsic atopic dermatitis and the hygiene hypothesis: results from a cross-sectional studyA Zutavern
Dr von Haunersches Kinderspital University Children s Hospital, Munich, Germany
Clin Exp Allergy 35:1301-8. 2005..AD can be differentiated into an allergic extrinsic form (EAD) and a non-allergic intrinsic form (IAD)...
- Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramersHe Li
Eppley Institute and Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
Biochem J 411:425-32. 2008..in the neuromuscular junctions and the central nervous system is anchored to membranes through interactions with ColQ (AChE-associated collagen tail protein) and PRiMA (proline-rich membrane anchor) proteins containing proline-rich ..
- Assembly and regulation of acetylcholinesterase at the vertebrate neuromuscular junctionR L Rotundo
Department of Cell Biology and Anatomy, The University of Miami School of Medicine, 1600 N W 10th Avenue, Miami, FL 33136, USA
Chem Biol Interact 175:26-9. 2008The collagen-tailed form of acetylcholinesterase (ColQ-AChE) is the major if not unique form of the enzyme associated with the neuromuscular junction (NMJ)...
- The diagnostic value of combining carbohydrate-deficient transferrin, fibrosis, and steatosis biomarkers for the prediction of excessive alcohol consumptionFrancoise Imbert-Bismut
Department of Biochemistry, APHP Groupe Hospitalier Pitié Salpétrière, Paris, France
Eur J Gastroenterol Hepatol 21:18-27. 2009The validity of biomarkers of excessive alcohol drinking (EAD) (30 g/day or more), such as carbohydrate-deficient transferrin (CDT%), is confounded by liver disease severity...
- Analysis of Ewing sarcoma (EWS)-binding proteins: interaction with hnRNP M, U, and RNA-helicases p68/72 within protein-RNA complexesSteffen Pahlich
Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
J Proteome Res 8:4455-65. 2009..belongs to the TET family of RNA-binding proteins and consists of an N-terminal transcriptional activation domain (EAD) and a C-terminal RNA-binding domain (RBD), which is extensively methylated at arginine residues...
- Aerosol measurement of airspace diameter correlates with morphometry in normal and papain-exposed air dried lungsF S Rosenthal
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907, USA
Exp Lung Res 25:425-41. 1999Aerosol measures of effective airspace diameter (EAD) were correlated with morphometric parameters in a series of 8 canine lungs, 5 of which had been exposed to papain in order to cause experimental emphysema...
- Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wallG X Yan
Main Line Health Heart Center, Wynnewood, PA, USA
Circulation 103:2851-6. 2001This study examined the role of phase 2 early afterdepolarization (EAD) in producing a trigger to initiate torsade de pointes (TdP) with QT prolongation induced by dl-sotalol and azimilide...
- Odor composition of preferred (buffalo and ox) and nonpreferred (waterbuck) hosts of some Savanna tsetse fliesNicholas K Gikonyo
International Centre of Insect Physiology and Ecology, Nairobi, Kenya
J Chem Ecol 28:969-81. 2002..octadecyl bonded) silica and analyzed with a gas chromatography-linked electroantennographic detector (GC-EAD) and, where possible, identified by using gas chromatography-linked mass spectrometry (GC-MS) and chromatographic ..
- Neuropathologic substrate of mild cognitive impairmentWilliam R Markesbery
Alzheimer s Disease Center, University of Kentucky, Lexington, KY 40536 0230, USA
Arch Neurol 63:38-46. 2006To define the neuropathologic findings in amnestic mild cognitive impairment (MCI) and early Alzheimer disease (EAD).
- Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veinsEugene Patterson
University of Oklahoma Health Sciences Center and the DVA Medical Center, Oklahoma City, Oklahoma, USA
J Am Coll Cardiol 47:1196-206. 2006....
- Spontaneous pulmonary vein firing in man: relationship to tachycardia-pause early afterdepolarizations and triggered arrhythmia in canine pulmonary veins in vitroEugene Patterson
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
J Cardiovasc Electrophysiol 18:1067-75. 2007..Rapid firing originating within pulmonary veins (PVs) initiates atrial fibrillation (AF). The following studies were performed to evaluate spontaneous PV firing in patients with AF to distinguish focal versus reentrant mechanisms...
- Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2Carl Sims
University of Pittsburgh, School of Medicine, Department of Cell Biology and Physiology, Pittsburgh, PA 15261, USA
Circ Res 102:e86-100. 2008..Therefore, sex, age, and regional differences in I(Ca,L) density and in EAD susceptibility were analyzed in epicardial left ventricular myocytes isolated from the apex and base of prepubertal ..
- [Effects of BmKIM on sodium current of isolated cardiomyocytes, transmembrane action potential and aconitine induced arrhythmia in vivo in rabbits]Teng Wang
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
Zhonghua Xin Xue Guan Bing Za Zhi 37:102-7. 2009....
- CCAAT/enhancer binding protein alpha binds to the Epstein-Barr virus (EBV) ZTA protein through oligomeric interactions and contributes to cooperative transcriptional activation of the ZTA promoter through direct binding to the ZII and ZIIIB motifs during Frederick Y Wu
Molecular Virology Laboratories, Department of Pharmacology and Molecular Sciences, School of dicine, The Johns Hopkins University, Baltimore, Maryland 21231 1000, USA
J Virol 78:4847-65. 2004..Finally, double-label immunofluorescence assays suggested that EAD protein expression was activated even better than ZTA expression in latently infected C/EBPalpha-transfected Akata ..
- Expression and localization of acetylcholinesterase at the neuromuscular junctionRichard L Rotundo
Department of Cell Biology and Anatomy and Neuroscience Program, University of Miami School of Medicine, Miami, Florida 33136, USA
J Neurocytol 32:743-66. 2003..large protein consists of three catalytic tetramers covalently linked to the three-stranded collagen-like tail (ColQ)...
- Increasing gap junction coupling reduces transmural dispersion of repolarization and prevents torsade de pointes in rabbit LQT3 modelXiao Qing Quan
Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
J Cardiovasc Electrophysiol 18:1184-9. 2007..This study examined the effects of antiarrhythmic peptide AAP10, a gap junction enhancer, on TDR and induction of TdP in a rabbit LQT3 model...
- Viral vector-mediated [corrected] expression of human collagen Q in cultured cellsMikako Ito
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Japan
Chem Biol Interact 175:346-8. 2008..Collagen Q (ColQ) makes a triple helical structure and anchors the catalytic subunit of acetylcholinesterase (AChE) to the synaptic ..
- Training veterinary personnel for effective identification and diagnosis of exotic animal diseasesCarmel M Kerwick
J Vet Med Educ 35:255-61. 2008The requirements for exotic animal disease (EAD) training were considered at a workshop organized for those with responsibilities for EAD response management in the different states of Australia, with the objective of identifying the ..
- Composition and electrophysiological activity of constituents identified in male wing gland secretion of the bumblebee parasite Aphomia sociellaBlanka Kalinová
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam 2, CZ 166 10 Praha 6, Czech Republic
J Nat Prod 72:8-13. 2009..gas chromatography, electroantennography (EAG), gas chromatography with electroantennographic detection (GC-EAD), and NMR...
- Fever accentuates transmural dispersion of repolarization and facilitates development of early afterdepolarizations and torsade de pointes under long-QT ConditionsAlexander Burashnikov
Masonic Medical Research Laboratory, Utica, NY 13501, USA
Circ Arrhythm Electrophysiol 1:202-8. 2008..The present study examines the effect of hyperthermia on transmural dispersion of action potential duration (TD-APD), early afterdepolarization (EAD) activity, and torsade de pointes (TdP) under long-QT conditions.
- [Molecular bases and therapeutic strategies in defective neuromuscular transmissions: lessons learned from a prototypical synapse]Kinji Ohno
Division of Neurogenetics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 29:145-51. 2009..1) Defects in choline acetyltransferase reduce acetylcholine contents at the nerve terminal. (2) Collagen Q (ColQ) anchors acetylcholinesterase at the synaptic basal lamina, and its defects cause endplate acetylcholinesterase ..
- (Z,Z)-4,7-tridecadien-(S)-2-yl acetate: sex pheromone of Douglas-fir cone gall midge, Contarinia oregonensisRegine Gries
Centre for Environmental Biology, Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 Canada
J Chem Ecol 28:2283-97. 2002..Coupled gas chromatographic-electroantennographic detection (GC-EAD) analyses of pheromone extract revealed a single compound (A) that elicited responses from male antennae...
- Analysis of chromosome aberrations in nuclear-power-plant workers considering the lifetime of lymphocytesH W Chung
School of Public Health, Seoul National University, Korea
Int J Radiat Biol 76:923-7. 2000..To analyse chromosome aberrations in nuclear-power-plant workers taking account of the mean lifetime of lymphocytes (MLTL)...
- A new supraglottic airway, the Elisha Airway Device: a preliminary studySonia J Vaida
Department of Anesthesiology, Bnai Zion Medical Center, Haifa, Israel
Anesth Analg 99:124-7. 2004We describe the Elisha Airway Device (EAD), a new reusable supraglottic ventilatory device...
- Performance of two new electrochemical treatment systems for wastewatersChuanping Feng
Science and Technology Promotion Foundation of Ibaraki, Tsukuba, Ibaraki, Japan
J Environ Sci Health A Tox Hazard Subst Environ Eng 39:2533-43. 2004..A series of experiments was performed using effluents from an anaerobic digester (EAD) of cattle wastewater, supernatants from primary sedimentation in a sewage plant (SPS), and domestic wastewater to ..
- Mastrus ridibundus parasitoids eavesdrop on cocoon-spinning codling moth, Cydia pomonella, larvaeZaid Jumean
Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A1S6, Canada
Naturwissenschaften 92:20-5. 2005..In gas chromatographic-electroantennographic detection (GC-EAD) analyses of bioactive Porapak Q extract of cocoon-derived airborne semiochemicals, ten compounds elicited ..
- Improvement pattern in the clock drawing test in early Alzheimer's diseaseJesus Cacho
Section of Neurology, Salamanca University Hospital, Salamanca, Spain
Eur Neurol 53:140-5. 2005The aim of this paper was to compare the performance of a group of patients with early Alzheimer's disease (EAD) against a control group of healthy control (HC) subjects in the Clock Drawing Test (CDT), i.e...
- Mechanisms underlying the effects of the pyrethroid tefluthrin on action potential duration in isolated rat ventricular myocytesC Ian Spencer
Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Pharmacol Exp Ther 315:16-23. 2005..In some action potentials, tefluthrin also activated early after-depolarizations (EADs). Using a selected EAD-containing action potential clamp, we observed that EADs could evoke a Cd2+-sensitive membrane current (I(EAD)) ..
- Enteral access in home careMark H Delegge
Coram Healthcare, Section of Nutrition, Digestive Disease Center, Medical University of South Carolina, South Carolina, USA
JPEN J Parenter Enteral Nutr 30:S13-20. 2006..For those patients who cannot or will not swallow, an enteral access device (EAD) is required. Some of these devices can be passed through the oral or nasal cavity into the stomach or small bowel...
- [Characteristics of the action potentials and the underlying ionic mechanisms in the cardiomyocytes from rabbit pulmonary vein sleeves]Huai Yu Ding
Heart Center, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China
Sheng Li Xue Bao 58:129-35. 2006..a second plateau response could be induced easily, suggesting a strong tendency of early afterdepolarization (EAD) genesis in PVC. Non-selective cation current (I(NSCC)) was first recorded in both LAC and PVC...
- The characteristics of action potential and nonselective cation current of cardiomyocytes in rabbit superior vena cavaPan Wang
Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Sci China C Life Sci 51:326-35. 2008..showed slow response action potentials with automatic activity and some others showed early after depolarization (EAD) spontaneously...
- Detecting navigational deficits in cognitive aging and Alzheimer disease using virtual realityLaura A Cushman
Department of Neurology, Brain and Cognitive Sciences, Center for Visual Science, The University of Rochester Medical Center, Rochester, NY14642, USA
Neurology 71:888-95. 2008..Here we compare our previously described real-world navigation test with a virtual reality (VR) version simulating the same navigational environment...
- [Distribution and risk factors of steno-occlusive lesions in patients with ischemic cerebrovascular disease]Dou Li
Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing, China
Zhonghua Yi Xue Za Zhi 88:1158-62. 2008..To investigate the distribution of atherosclerotic steno-occlusive lesions in Chinese patients with ischemic cerebrovascular disease and the risk factors for occlusive lesions of intracranial and extracranial arteries...
- Early experience with percutaneous cryoablation of extra-abdominal desmoid tumorsJennifer L Kujak
Department of Radiology, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA
Skeletal Radiol 39:175-82. 2010..resection, radiation therapy and chemotherapy are all accepted as standard treatments for extra-abdominal desmoid (EAD) tumors, but their effectiveness has been limited by frequent local recurrence...
- Methyl 6-methylsalicylate: a female-produced pheromone component of the parasitoid wasp Spalangia endiusWilliam J Nichols
Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
J Chem Ecol 36:1140-7. 2010..Male antennae were sensitive to both compounds in electrophysiological tests (GC-EAD)...
- Peripheral modulation of pheromone response by inhibitory host compound in a beetleMartin N Andersson
Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural Sciences, SE 230 53 Alnarp, Sweden
J Exp Biol 213:3332-9. 2010We identified several compounds, by gas chromatographic-electroantennographic detection (GC-EAD), that were antennally active in the bark beetle Ips typographus and also abundant in beetle-attacked spruce trees...
- Glycolytic inhibition causes spontaneous ventricular fibrillation in aged heartsNorishige Morita
Translational Arrhythmia Research Section, Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA, 675 Charles E Young Dr South, MRL 3645 Mail Code 176022, Los Angeles, CA 90095, USA
Am J Physiol Heart Circ Physiol 301:H180-91. 2011..We sought to determine whether GI promotes triggered activity by early afterdepolarization (EAD) or delayed afterdepolarizations in intact hearts isolated from adult and aged rats...
- Does the association of 18F-FDG uptake intensity and lesion topography reveal histological phenotype and tumor differentiation in esophageal cancer?Alessio Imperiale
Service de Biophysique et de Medecine Nucleaire, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Avenue Moliere, 67098 Strasbourg, France
Hell J Nucl Med 14:239-42. 2011..practice, the esophageal squamous cell cancer (ESCC) is considered to be more (18)F-FDG avid than adenocarcinoma (EAD)...
- Identification of male-produced aggregation pheromone of the curculionid beetle Sternechus subsignatusBianca G Ambrogi
Laboratório de Semioquímicos, Departamento de Quimica, Universidade Federal do Parana, CP 19081, CEP 81531 990, Curitiba, PR, Brazil
J Chem Ecol 38:272-7. 2012..subsignatus in olfactometer bioassays. Studies are in progress to evaluate the biological activity of the major component and the EAD-active mixture under field conditions.
- Identification and field evaluation of pear fruit volatiles attractive to the oriental fruit moth, Cydia molestaPeng Fei Lu
State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, People s Republic of China
J Chem Ecol 38:1003-16. 2012..Attractiveness of synthetic blends to adults based on gas chromatography-electroantennogram detection (GC-EAD) activity was investigated in both field and laboratory...
- Characterization of epoxytrienes derived from (3Z,6Z,9Z)-1,3,6,9-tetraenes, sex pheromone components of arctiid moths and related compoundsRei Yamakawa
Graduate School of Bio Applications and Systems Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184 8588, Japan
J Chem Ecol 38:1042-9. 2012..GC-EAD analysis of the optically pure epoxides showed that the antennae of male H...
- Pregnancy in congenital myasthenic syndromeL Servais
Service of therapeutic trials and databases, Institut de Myologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
J Neurol 260:815-9. 2013..We report on 17 pregnancies in eight patients with CMS with mutations in CHRNA1, CHRNE, CHRND, GFPT1, COLQ, or DOK7...
- Female sex pheromone secreted by Carmenta mimosa (Lepidoptera: Sesiidae), a biological control agent for an invasive weed in VietnamLe Van Vang
Department of Plant Protection, College of Agriculture and Applied Biology, Can Tho University, Can Tho City, Vietnam
Biosci Biotechnol Biochem 76:2153-5. 2012..which is one of the most invasive weeds in Vietnam. GC-EAD and GC-MS analyses of a pheromone gland extract revealed that the female moths produced (3Z,13Z)-3,13-..
- Circadian release of male-specific components of the greater date moth, Aphomia (Arenipses) sabella, using sequential SPME/GC/MS analysisAnat Levi-Zada
Institute of Plant Protection, Agricultural Research Organization, Volcani Center, Bet Dagan, 50250, Israel
J Chem Ecol 40:236-43. 2014..This is the first finding of a circadian release of male-specific compounds in moths. GC/EAD analyses with synthetic standards of compounds released by males showed that the female antenna is stimulated by ..
- Enhanced digestion of waste activated sludge using microbial electrolysis cells at ambient temperatureJoseph R Asztalos
Department of Civil Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada
Water Res 87:503-12. 2015..Two lab-scale digesters, a control anaerobic digester and an electrically-assisted digester (EAD - equipped with a MEC bioanode and cathode) were operated under three solids retention times (SRT = 7, 10 and 14 ..
- Early Allograft Dysfunction After Liver Transplantation Is Associated With Short- and Long-Term Kidney Function ImpairmentH M Wadei
Mayo Clinic Collaborative in Transplant Research and Outcomes, Department of Transplant, Mayo Clinic Florida, Jacksonville, FL
Am J Transplant 16:850-9. 2016Early allograft dysfunction (EAD) after liver transplantation (LT) is related to ischemia-reperfusion injury and may lead to a systemic inflammatory response and extrahepatic organ dysfunction...
- The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic MosaicsJuliane Mundorf
Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne
J Vis Exp . 2016..how to generate fluorescently labeled clonal tumors of varying malignancy in the eye/antennal imaginal discs (EAD) of Drosophila larvae using the Mosaic Analysis with a Repressible Cell Marker (MARCM) technique...
- Exhaust Air Dust Monitoring is Superior to Soiled Bedding Sentinels for the Detection of Pasteurella pneumotropica in Individually Ventilated Cage SystemsManuel Miller
Research Unit for Comparative Medicine, Helmholtz Zentrum Mnchen, German Research Center for Environmental Health, Neuherberg, Germany, Email
J Am Assoc Lab Anim Sci 55:775-781. 2016..In this study, we investigated whether analysis of exhaust air dust (EAD) samples by using a sensitive and specific real-time PCR assay is superior to conventional SBS monitoring for the ..
- Cytoskeleton proteins in CSF distinguish frontotemporal dementia from ADM Sjogren
Institute of Clinical Neuroscience, Goteborg University, Sweden
Neurology 54:1960-4. 2000..Both proteins have been implicated in the pathophysiology of FTD...
- Differences in action potential and early afterdepolarization properties in LQT2 and LQT3 models of long QT syndromeC R Studenik
Institute of Pharmacology and Toxicology, University of Vienna, Vienna, Austria
Br J Pharmacol 132:85-92. 2001..Action potential and early afterdepolarization (EAD) properties were rigorously defined by the frequency power spectra obtained with fast Fourier transforms. 3...
- Spontaneous, electrically, and cesium chloride induced arrhythmia and afterdepolarizations in the rapidly paced dog heartD L Jones
Departments of Physiology and Medicine, University of Western Ontario, London, Ontario, Canada, N6A 5C1
Pacing Clin Electrophysiol 24:474-85. 2001..induced arrhythmia and the susceptibility of the failing dog heart to arrhythmia and early afterdepolarization (EAD) induced triggered activity elicited by exogenous administration of cesium chloride (CsCl)...
- Volatiles associated with preferred and nonpreferred hosts of the Nantucket pine tip moth, Rhyacionia frustranaC Asaro
Department of Entomology, University of Georgia, 413 Biological Sciences, Athens, Georgia 30602, USA
J Chem Ecol 30:977-90. 2004..frustrana host preference. Gas chromatographic-electroantennographic detection (GC-EAD) analyses of standards identified 19 different seedling-associated compounds that elicited antennal responses from ..
- Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's diseaseM A Lovell
Sanders Brown Center on Aging and Departments of Chemistry, Neurology and Pathology, University of Kentucky, Lexington, KY 40536, USA
Neurotox Res 7:265-71. 2005..levels in the HPG, SMTG and CER of 5 subjects with mild cognitive impairment (MCI), 5 subjects with early AD (EAD) and 4 appropriately age-matched controls. Western blot and dot-blot analysis showed statistically significant (p 0...
- 1,4-Dimethoxybenzene, a floral scent compound in willows that attracts an oligolectic beeStefan Dötterl
Department of Plant Systematics, University of Bayreuth, 95440 Bayreuth, Germany
J Chem Ecol 31:2993-8. 2005..and the samples were subsequently analyzed by coupled gas chromatographic-electroantennographic detection (GC-EAD) to detect possible attractants of A. vaga...
- Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteinsKing Pan Ng
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, S A R China
Proc Natl Acad Sci U S A 104:479-84. 2007..more than a decade ago, molecular analysis has been greatly hindered by the repetitive EWS activation domain (EAD) structure, containing multiple degenerate hexapeptide repeats (consensus SYGQQS) with a conserved tyrosine residue...
- [Cardiopulmonary resuscitation with semi-automated external defibrillator: assessment of the teaching-learning process]Ana Maria Kazue Miyadahira
Departamento de Enfermagem Médico Cirúrgica da Escola de Enfermagem, Universidade de São Paulo EEUSP, Sao Paulo, SP, Brasil
Rev Esc Enferm USP 42:532-8. 2008..sample was composed of 40 administrative workers of a public institution that were trained on CPR technique using EAD, as an experiment...
- Role of oxidative stress in the progression of Alzheimer's diseaseRukhsana Sultana
Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
J Alzheimers Dis 19:341-53. 2010..the appearance of the same oxidized brain proteins from subjects with mild cognitive impairment (MCI), early AD (EAD), and late-stage AD, and relating these findings to the reported AD pathology...
- Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cellsTarvo Rajasalu
Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany
Diabetes 59:1966-73. 2010..established model to characterize preproinsulin-specific CD8 T-cell responses and experimental autoimmune diabetes (EAD)...
- Rapid multiplex detection and differentiation of Listeria cells by use of fluorescent phage endolysin cell wall binding domainsMathias Schmelcher
Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse, 7, CH 8092 Zurich, Switzerland
Appl Environ Microbiol 76:5745-56. 2010..These proteins feature a modular organization, consisting of an N-terminal enzymatically active domain (EAD), which contributes lytic activity, and a C-terminal cell wall binding domain (CBD), which targets the lysin to its ..
- A transcription assay for EWS oncoproteins in Xenopus oocytesKing Pan Ng
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon Hong Kong, China
Protein Cell 1:927-34. 2010..EFPs are potent transcriptional activators, dependent on the N-terminal region of EWS (the EWS-activation-domain, EAD) and this function is thought to be central to EFT oncogenesis and maintenance...
- Identification of mosquito repellent odours from Ocimum forskoleiTeun Dekker
Division of Chemical Ecology, Department of Crop Science, Swedish University of Agricultural Sciences PO 44, Alnarp, SE 23053, Sweden
Parasit Vectors 4:183. 2011..We verified whether active repellent compounds could be identified using gas-chromatography coupled electroantennogram recordings (GC-EAD) with headspace extracts of crushed plants.
- Early Alzheimer's disease blocks responses to accelerating self-movementRoberto Fernandez
Department of Neurology, Brain and Cognitive Sciences, University of Rochester Medical Center, Rochester, NY 14642 0673, USA
Neurobiol Aging 33:2551-60. 2012..Young (YNC) and older (ONC) normal controls, and early AD patients (EAD) viewed real-world videos and dot motion stimuli simulating self-movement scenes...
- Controlling equine influenza: policy networks and decision-making during the 2007 Australian equine influenza outbreakK Schemann
Faculty of Veterinary Science, The University of Sydney, Camden, NSW, Australia
Transbound Emerg Dis 61:449-63. 2014..Training to increase awareness and knowledge of emergency animal diseases (EADs) and response systems will improve stakeholder participation in emergency disease management and preparedness for future EAD incursions.
- Early allograft dysfunction is associated with excess resource utilization after liver transplantationK P Croome
Multi Organ Transplant Program, London Health Sciences Centre, Western University, London, Ontario, Canada
Transplant Proc 45:259-64. 2013..The primary objective of this study was to examine the relationship between early allograft dysfunction (EAD) and LOS after LT...
- (6R,10S)-Pallantione: the first ketone identified as sex pheromone in stink bugsCarla F Fávaro
Universidade Federal do Parana, 81531 990 Curitiba PR, Brazil
Org Lett 15:1822-5. 2013..The biological activity of the synthetic pheromone was demonstrated by behavioral and EAD experiments...
- Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserveZhilin Qu
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Cardiovasc Res 99:6-15. 2013..However, this generalized condition is not sufficient for EAD genesis and does not explain the voltage oscillations manifesting as EADs...
- RICARDO ANIBAL MASELLI; Fiscal Year: 2014..receptor (AChR) subunit genes (CHRNA1, CHRNB1, CHRND, CHRNE), and the acetylcholinesterase (AChE) collagenic tail (COLQ) were shown to cause several forms of CMS...
- Lai Hua Xie; Fiscal Year: 2015..Pathological concentrations of H2O2 causes early afterdepolarization (EAD), delayed afterdepolarization (DAD), and triggered activity (TA), and has been suggested as a potential ..
- LAURA ANNE JACOX; Fiscal Year: 2015..The mouth develops from the "extreme anterior domain" (EAD), where the ectoderm and endoderm directly juxtapose...
- Sanda Despa; Fiscal Year: 2015..larger cellular and sarcoplasmic reticulum (SR) Ca load and increased frequency of early afterdepolarizations (EAD) and delayed afterdepolarizations (DAD)...
- The role of dynamic changes in repolarization and calcium transients in Long QT rBum Rak Choi; Fiscal Year: 2013..QT related arrhythmias including tissue characteristics as substrate for reentry and conditions that exacerbate EAD inductions and pVTs...
- Gideon Koren; Fiscal Year: 2016..tissue heterogeneities mediate the R-on-T phenomenon as well as test whether short-long-short sequence increases EAD formations and tissue heterogeneities, thus self propels until the onset of TdP and weather TdP and PVT are ..
- Modeling of Cardiac Calcium Dynamics;Ryanodine Receptor induced ArrhythmiasDaisuke Sato; Fiscal Year: 2013..2) how an EAD or DAD from a single cell can cause a group of cells to simultaneously generate EADs or DADs to exceed the critical ..
- ROLE OF PROLONGED REPOLARIZATION IN CARDIAC ARRHYTHMIASDan Roden; Fiscal Year: 1992..One of the most important findings to date is that ventricular muscle blunts the action potential prolongation and EAD induction by quinidine in Purkinje tissue...
- MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGSDavid Flockhart; Fiscal Year: 2001..perfused heart using the characteristics of the action potential (AP), QT interval and early after depolarization (EAD) occurrence...
- Mechanisms for SIV evasion of vaccine immunity: Role of FasL-mediated cell deathCHARLES PAUZA; Fiscal Year: 2009..are mounting anti-viral immune responses may be important in the failure to contain the initial viremia, and may ead to the establishment of persistent infection with chronic disease...
- Maria T Britto; Fiscal Year: 2014..Through this research, we will gather data on feasibility, usability and efficacy of the intervention that will ead to a future R01 application to examine the intervention's efficacy in a fully powered randomized trial.
- H-Tunneling in Methylmalonyl-CoA MutaseRuma Banerjee; Fiscal Year: 2004..values for the ratio of the Arrhenius preexponential factors (AH/AD) and for the difference in activation energies (EaD-EaH) that lie well outside the semiclassical range...
- CALMODULIN KINASE II AND EARLY AFTERDEPOLARIZATIONSMark Anderson; Fiscal Year: 2007..for many EADs, but ICa also provides intracellular Ca2+ ([Ca2+]i) for activating signaling molecules linked to EAD initiation...
- EARLY AFTER DEPOLARIZATIONS--MECHANISM/ROLE OF CALCIUMCraig January; Fiscal Year: 1993..in voltage clamped and non-voltage clamped Purkinje strands with this model have permitted us to hypothesize that EAD induction 1 requires: 1) Lengthening and flattening of the action potential plateau within a voltage range where, 2)..
- Fax to Quit: Linking Smokers Visiting Clinics to State QuitlinesMichael Fiore; Fiscal Year: 2009..evaluate two forms of Fax to Quit: Fax to Quit alone (FQ) and Fax to Quit plus Enhanced Academic Detailing (FQ + EAD) with EAD comprising ongoing training/technical assistance and performance feedback...
- REGULATION OF ACETYLCHOLINESTERASE SYNTHESIS & ASSEMBLYRICHARD ROTUNDO; Fiscal Year: 2009..This includes the interactions of ColQ with the muscle-specific kinase MuSK using co-expression and overexpression of these various proteins...
- Acetylcholinesterase: A Comparative Biochemical ApproachLeo Pezzementi; Fiscal Year: 2005..abstract_text> ..
- RESPONSE OF THE AGING NERVOUS SYSTEM TO TRAUMAStephen Scheff; Fiscal Year: 2007..unreadable] [unreadable]..
- NERVE SPROUTING AND ELECTRICAL REMODELINGPeng Sheng Chen; Fiscal Year: 2003..These studies may lead to novel insights into the mechanisms of ventricular arrhythmogenesis after MI and may help develop new methods for arrhythmia control. ..
- DISRUPTION OF ZINC HOMEOSTASIS IN ALZHEIMER'S DISEASEMark Lovell; Fiscal Year: 2004....
- THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISMKim Olthoff; Fiscal Year: 2004..The applicant will assess basic parameters of glucose metabolism in IGFBP-1 null mice and determine the basis for any abnormalities. ..
- Mechnaisms of Late Sodium Current in Failing HeartAlbertas Undrovinas; Fiscal Year: 2006..Knowledge derived from the present proposal may reveal novel targets for the treatment of life-threatening arrhythmias associated with chronic HF. ..
- Fibrillation and DefibrillationPeng Sheng Chen; Fiscal Year: 2010..Our preliminary studies showed that late phase 3 EAD may also play a role in postshock arrhythmias in failing and ischemic hearts...
- Functional Coupling between Ito and ICa in CardiomyocytesYanggan Wang; Fiscal Year: 2010..The proposed study implicates a cell membrane potassium channel (Ito) in regulating the cellular calcium influx channel (ICa) function, which may decipher a new mechanism for this morbid disease. ..
- SYNAPTIC CHANGE IN MILD COGNITIVE IMPAIRMENTStephen W Scheff; Fiscal Year: 2010..Successful completion of the proposed studies will lead to new insights into the mechanisms underlying MCI and early AD and contribute to the development of effective pharmacologic therapies for AD. ..
- Liver Regeneration in the Transplant SettingKIM MARIE OLTHOFF; Fiscal Year: 2010..Understanding the mechanistic biology of graft recovery and pathways of liver regeneration will provide important data for designing treatment modalities that will prevent injury and enhance recovery and regeneration. ..
- TRAUMATIC BRAIN INJURY AND CELLULAR HOMEOSTASISStephen Scheff; Fiscal Year: 2003..These studies will significantly enhance our understanding of the mechanisms following TBI and hopefully lead to therapies resulting in increased recovery. ..