CNR1

Summary

Gene Symbol: CNR1
Description: cannabinoid receptor 1
Alias: CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1, cannabinoid receptor 1 (brain), central cannabinoid receptor
Species: human

Top Publications

  1. pmc Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
  2. ncbi The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein
    A Porcella
    Center for Neuropharmacology, C N R and B B Brodie Department of Neuroscience, University of Cagliari, and Neuroscienze Scarl, Cagliari, Italy
    Eur J Neurosci 12:1123-7. 2000
  3. ncbi High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    T C Islam
    Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Leukemia 17:1880-90. 2003
  4. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
  5. ncbi Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma
    Xundi Xu
    Department of Surgery, Xiangya 2nd Hospital, Central South University, Renming Zhong Road 139, Changsha City, Hunan Province, China
    Cancer Genet Cytogenet 171:31-8. 2006
  6. ncbi Presence of functional cannabinoid receptors in human endocrine pancreas
    F J Bermudez-Silva
    Fundacion IMABIS, Hospital Carlos Haya, Avenida Carlos Haya 82, 7a Planta, Pabellon A, 29010 Malaga, Spain
    Diabetologia 51:476-87. 2008
  7. ncbi Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes
    Christine Börner
    Department of Pharmacology and Toxicology, Magdeburg University, 44 Leipzigerstrasse, 39120 Magdeburg, Germany
    Mol Pharmacol 73:1013-9. 2008
  8. pmc Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes
    Heather M Haughey
    University of Colorado at Boulder, Boulder, CO, USA
    Addiction 103:1678-86. 2008
  9. doi Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype
    Judit Lazary
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 150:1118-27. 2009
  10. pmc Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues
    Francesca M Filbey
    The MIND Research Network, Albuquerque, NM 87106, USA
    Neuropsychopharmacology 35:967-75. 2010

Research Grants

  1. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
  2. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2009
  3. Virginia S Seybold; Fiscal Year: 2014
  4. BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)
    Emmanuel S Onaivi; Fiscal Year: 2012
  5. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
  6. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
  7. Examination of endocannabinoid elevation and extinction learning
    JASON MICHAEL WIEBELHAUS; Fiscal Year: 2013
  8. Daniele Piomelli; Fiscal Year: 2016
  9. DONALD SIMONE; Fiscal Year: 2014
  10. Alexandros Makriyannis; Fiscal Year: 2016

Detail Information

Publications212 found, 100 shown here

  1. pmc Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
    ..Here we show that CB1 expression was silenced in human colorectal cancer due to methylation of the CB1 promoter...
  2. ncbi The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein
    A Porcella
    Center for Neuropharmacology, C N R and B B Brodie Department of Neuroscience, University of Cagliari, and Neuroscienze Scarl, Cagliari, Italy
    Eur J Neurosci 12:1123-7. 2000
    ..polymerase chain reaction to detect the expression of the central and peripheral cannabinoid receptors (CB1 and CB2, respectively) mRNA, and Western blotting to show the presence of the CB1 protein in subregions of the ..
  3. ncbi High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    T C Islam
    Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Leukemia 17:1880-90. 2003
    ..Of special interest was the high expression of the cannabinoid receptor 1 (CB1) gene in all MCL cases analysed...
  4. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..promoter producing a novel 5'-untranslated region of cannabinoid receptor mRNA has recently been described in CNR1, the gene encoding the cannabinoid receptor protein...
  5. ncbi Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma
    Xundi Xu
    Department of Surgery, Xiangya 2nd Hospital, Central South University, Renming Zhong Road 139, Changsha City, Hunan Province, China
    Cancer Genet Cytogenet 171:31-8. 2006
    b>CB1 and CB2 are multifunctional cannabinoid-specific receptors considered to be involved in inhibition of tumor development...
  6. ncbi Presence of functional cannabinoid receptors in human endocrine pancreas
    F J Bermudez-Silva
    Fundacion IMABIS, Hospital Carlos Haya, Avenida Carlos Haya 82, 7a Planta, Pabellon A, 29010 Malaga, Spain
    Diabetologia 51:476-87. 2008
    We examined the presence of functional cannabinoid receptors 1 and 2 (CB1, CB2) in isolated human islets, phenotyped the cells producing cannabinoid receptors and analysed the actions of selective cannabinoid receptor agonists on insulin,..
  7. ncbi Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes
    Christine Börner
    Department of Pharmacology and Toxicology, Magdeburg University, 44 Leipzigerstrasse, 39120 Magdeburg, Germany
    Mol Pharmacol 73:1013-9. 2008
    The majority of effects of cannabinoids are mediated by the two receptors CB1 and CB2. In addition to neuronal cells, CB1 receptors are expressed in T lymphocytes, in which they are involved in cannabinoid-induced T helper cell biasing...
  8. pmc Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes
    Heather M Haughey
    University of Colorado at Boulder, Boulder, CO, USA
    Addiction 103:1678-86. 2008
    ..were associated with polymorphisms within two genes involved in regulating the endocannabinoid system, cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH)...
  9. doi Promoter variants of the cannabinoid receptor 1 gene (CNR1) in interaction with 5-HTTLPR affect the anxious phenotype
    Judit Lazary
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 150:1118-27. 2009
    ..our study was to analyze the interaction of the promoter regions of the serotonin transporter (SLC6A4) and cannabinoid receptor 1 (CNR1) genes on anxiety...
  10. pmc Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues
    Francesca M Filbey
    The MIND Research Network, Albuquerque, NM 87106, USA
    Neuropsychopharmacology 35:967-75. 2010
    As previous work has highlighted the significance of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes with respect to cannabis dependence (CD), this study sought to characterize the neural mechanisms that ..
  11. pmc The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease
    Martin Storr
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 5:e9453. 2010
    Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p...
  12. pmc A common CNR1 (cannabinoid receptor 1) haplotype attenuates the decrease in HDL cholesterol that typically accompanies weight gain
    Qiping Feng
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 5:e15779. 2010
    We have previously shown that genetic variability in CNR1 is associated with low HDL dyslipidemia in a multigenerational obesity study cohort of Northern European descent (209 families, median  = 10 individuals per pedigree)...
  13. ncbi Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15
    M R Hoehe
    Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, MD 20892
    New Biol 3:880-5. 1991
    ..We have now determined the genomic location of the human cannabinoid receptor gene (CNR) by a combination of genetic linkage mapping and chromosomal in situ hybridization...
  14. ncbi Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1
    S Leroy
    INSERM E 0117 Université Paris V, Service Hospitalo Universitaire de Santé Mentale et Thérapeutique, Hopital Sainte Anne, Paris, France
    Am J Med Genet 105:749-52. 2001
    ..Cannabinoid receptor (CB1) is particularly concentrated in dopamine-modulated areas of the nervous system...
  15. ncbi Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence
    Lutz G Schmidt
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, D 55131, Mainz, Germany
    Drug Alcohol Depend 65:221-4. 2002
    ..a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls...
  16. ncbi CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia
    H Ujike
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Mol Psychiatry 7:515-8. 2002
    ..examine the cannabinoid hypothesis for pathogenesis of schizophrenia, we examined two kinds of polymorphisms of the CNR1 gene, which encodes human CB1 receptor, a subclass of central cannabinoid receptors, in schizophrenics and age-..
  17. ncbi Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor
    Ismael Galve-Roperh
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Mol Pharmacol 62:1385-92. 2002
    ..In conclusion, CB(1)-induced ERK activation was mediated by PI3K(IB) and this effect may have important consequences in the control of cell death/survival decision...
  18. ncbi Expression of functionally active cannabinoid receptor CB1 in the human prostate gland
    Lidia Ruiz-Llorente
    Departmento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Alcala, Alcala de Henares, Madrid, Spain
    Prostate 54:95-102. 2003
    ..The aim of this study was to analyze the expression of cannabinoid receptors in the human prostate gland and their regulatory effects on adenylyl cyclase activity...
  19. ncbi Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain
    Susana Mato
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
    Eur J Neurosci 17:1747-54. 2003
    ..However, the pre- and postnatal pattern of appearance of CB1 cannabinoid receptors in humans has not been analysed in detail...
  20. ncbi Association study of cannabinoid receptor gene (CNR1) alleles and anorexia nervosa: differences between restricting and binging/purging subtypes
    Z Siegfried
    Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel
    Am J Med Genet B Neuropsychiatr Genet 125:126-30. 2004
    ..hypothesis whether a polymorphism of the CNR1 gene, which encodes human CB1 receptor, a subclass of the central cannabinoid receptor, contributes to the susceptibility to AN...
  21. ncbi (AAT)n repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population
    N Ballon
    Department of Psychiatry, University Hospital of Fort de France, Fort de France, Martinique, French West Indies
    Pharmacogenomics J 6:126-30. 2006
    ..We examined the (AAT)n triplet repeat polymorphism nearby the CNR1 gene, which encodes human cannabinoid (CB1) receptor, in a male Afro-Caribbean population...
  22. ncbi Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
    ..The cannabinoid receptor 1 (CNR1) is the best-characterized molecule of the endocannabinoid system, involved in processing rewards...
  23. pmc Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents
    Christian J Hopfer
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Med Genet B Neuropsychiatr Genet 141:895-901. 2006
    Cannabis is a major substance of abuse, and the gene encoding for the central cannabinoid receptor (CNR1) is a logical candidate gene for vulnerability toward developing symptoms of cannabis dependence...
  24. ncbi Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids
    Christine Börner
    Department of Pharmacology and Toxicology, University of Magdeburg, Leipzigerstr 44, 39120 Magdeburg, Germany
    J Leukoc Biol 81:336-43. 2007
    Effects of cannabinoids (CBs) are mediated by two types of receptors, CB1 and CB2...
  25. pmc Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes...
  26. ncbi Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest
    Sami Sarfaraz
    Department of Dermatology, Medical Sciences Center, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 281:39480-91. 2006
    ..Based on these data we suggest that cannabinoid receptor agonists should be considered as novel agents for the management of prostate cancer...
  27. ncbi Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population
    P Gazzerro
    Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy
    Int J Obes (Lond) 31:908-12. 2007
    Endocannabinoids control food intake via both central and peripheral mechanisms, and cannabinoid type-1 receptor (CB1) modulates lipogenesis in primary adipocyte cell cultures and in animal models of obesity.
  28. ncbi No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids...
  29. ncbi Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men
    Paola Russo
    Unit of Epidemiology and Population Genetics, Institute of Food Sciences, Consiglio Nazionale delle Ricerche, via Roma 52A C, Avellino, Italy
    J Clin Endocrinol Metab 92:2382-6. 2007
    ..The endocannabinoid system modulates food intake and body weight in animal models. Treatment with the cannabinoid type 1 receptor blocker, rimonabant, reduces body weight in obese individuals...
  30. ncbi CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    Human cannabinoid receptor 1 (CB1), which is encoded by the CNR1 gene, may play a role in the development of substance dependence (SD)...
  31. ncbi The CNR1 gene as a pharmacogenetic factor for antipsychotics rather than a susceptibility gene for schizophrenia
    Nora Hamdani
    AP HP, Hôpital Louis Mourier Paris VII, Service de Psychiatrie, 178 rue des Renouillers, 92700 Colombes, France
    Eur Neuropsychopharmacol 18:34-40. 2008
    ..The possible role of a tag SNP (the 1359G/A polymorphism) of the gene encoding the cannabinoid receptor type 1 (CNR1) in schizophrenia and/or therapeutic response to atypical antipsychotics was assessed in a cohort of 133 French ..
  32. ncbi Immune-mediated activation of the endocannabinoid system in visceral adipose tissue in obesity
    K Kempf
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Horm Metab Res 39:596-600. 2007
    ..Therefore, expression of fatty acid amide hydrolase (FAAH), cannabinoid receptor 1 (Cb1), adiponectin, and tumor necrosis factor (TNF)-alpha was compared in visceral adipose tissue from 10 ..
  33. ncbi The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men
    Armand Peeters
    Department of Medical Genetics, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Antwerp University, Universiteitsplein 1, Wilrijk, Antwerp, 2610, Belgium
    Endocrine 31:138-41. 2007
    ..and lipogenesis via peripheral CB1 receptors, we hypothesized that genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity...
  34. ncbi Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals
    G Murdolo
    The Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine Diabetes, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    J Endocrinol Invest 30:RC17-21. 2007
    ..We suggest that insulin may play a key role in the obesity-linked dysregulation of the adipose ES at the gene level...
  35. doi Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians
    Cindy L Ehlers
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Twin Res Hum Genet 10:805-11. 2007
    ..between the (AAT)n triplet repeat polymorphism as well as 5 single nucleotide polymorphisms (SNPs) in or near the CNR1 receptor gene and impulsivity in Southwest California 'Mission' Indians (SWC)...
  36. pmc Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder
    Ake T Lu
    Department of Human Genetics, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008
    ..The cannabinoid receptor gene (CNR1) is a positional candidate gene due to its location near an identified ADHD linkage peak on chromosome 6, its role ..
  37. doi Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany
    Eur Neuropsychopharmacol 18:751-9. 2008
    ..Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 ..
  38. pmc Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population
    Janaína P Jaeger
    Departamento de Genetica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Caixa Postal 15053, 91501 970 Porto Alegre, RS, Brazil
    Dis Markers 25:67-74. 2008
    ..Different studies have investigated the relationship between polymorphisms of the cannabinoid receptor 1 (CNR1) gene and obesity with conflicting results...
  39. doi Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma
    Gabriella Czifra
    Department of Physiology, Medical and Health Science Center, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    J Cancer Res Clin Oncol 135:507-14. 2009
    Recently, functional cannabinoid receptor-1 (CB1) and vanilloid receptor-1 (TRPV1) have been described in human prostate and prostate cancer-derived cell lines where the activation of the receptors resulted in inhibition of cellular ..
  40. doi Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
    K Eckardt
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Auf m Hennekamp 65, 40225, Duesseldorf, Germany
    Diabetologia 52:664-74. 2009
    Cannabinoid type 1 receptor (CB1R) antagonists such as rimonabant (Rim) represent a novel approach to treat obesity and related metabolic disorders. Recent data suggest that endocannabinoids are also produced by human adipocytes...
  41. pmc CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy
    Andrew W Horne
    Department of Reproductive and Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, UK
    PLoS ONE 3:e3969. 2008
    ..In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct...
  42. pmc Variants in the CNR1 and the FAAH genes and adiposity traits in the community
    Wolfgang Lieb
    National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 17:755-60. 2009
    ..We hypothesize that common genetic variants in the CNR1 (encoding endocannabinoid receptor 1) and FAAH genes (encoding fatty acid amide hydrolase, a key enzyme hydrolyzing ..
  43. doi Altered pattern of cannabinoid type 1 receptor expression in adipose tissue of dysmetabolic and overweight patients
    Riccardo Sarzani
    Department of Internal Medicine, University of Ancona, Politecnica delle Marche, 60131 Ancona, Italy
    Metabolism 58:361-7. 2009
    ..activity of the endocannabinoid system in visceral adipose tissue (VAT) may be mediated by cannabinoid type 1 (CB1) receptor expression...
  44. doi CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms
    Gabriella Juhasz
    Neuroscience and Psychiatry Unit, School of Community Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    Neuropsychopharmacology 34:2019-27. 2009
    b>Cannabinoid receptor 1 (CB1) gene (CNR1) knockout mice are prone to develop anhedonic and helpless behavior after chronic mild stress. In humans, the CB1 antagonist rimonabant increases the risk of depressed mood disorders and anxiety...
  45. doi Single nucleotide change in the cannabinoid receptor-1 (CNR1) gene in colorectal cancer outcome
    Fernando Bedoya
    Centro de Investigacion, Hospital Universitario 12 de Octubre, Madrid, Spain
    Oncology 76:435-41. 2009
    ..rejected specimens of human colorectal cancers and paired normal tissues were studied to detect mutations in the CNR1 gene by sequencing method...
  46. pmc Presence and regulation of cannabinoid receptors in human retinal pigment epithelial cells
    Yan Wei
    Department of Ophthalmology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Mol Vis 15:1243-51. 2009
    ..Here we analyzed the expression of and changes in cannabinoid receptors (CB1 and CB2) and one enzyme responsible for endocannabinoid hydrolysis, fatty acid amide hydrolase (FAAH), in RPE cell ..
  47. doi Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans
    Marica Bordicchia
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, University Hospital of Ancona, Ancona, Italy
    Metabolism 59:734-41. 2010
    ..We studied perirenal VAT CB1 receptor expression in relation to anthropometry, VAT area and endocannabinoid levels, kidney microvascular damage (..
  48. ncbi Synergistic inhibition of human colon cancer cell growth by the cannabinoid CB1 receptor antagonist rimonabant and oxaliplatin
    Patrizia Gazzerro
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Fisciano Salerno, Italy
    Oncol Rep 23:171-5. 2010
    ..Our findings suggest that the combined synergic effect of SR141716 and oxaliplatin improves the blocking of colon cancer cell proliferation. Therefore, this combination merits further explorations in preclinical and clinical settings...
  49. doi The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain
    E Ramil
    Neuroinmunology Unit, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
    Mult Scler 16:139-46. 2010
    ..The purpose of this study was to evaluate a possible association of MS with polymorphic markers at the CNR1 gene, encoding the cannabinoid 1 (CB(1)) receptor...
  50. pmc The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas
    Eiron Cudaback
    Department of Pharmacology, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 5:e8702. 2010
    ..Cannabinoids represent unique compounds for treating tumors, including astrocytomas. Whether CB(1) and CB(2) receptors mediate this therapeutic effect is unclear...
  51. ncbi Cannabinoid 1 receptor blockade reduces atherosclerosis with enhances reverse cholesterol transport
    Koichi Sugamura
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    J Atheroscler Thromb 17:141-7. 2010
    A recent clinical study using coronary intravascular ultrasound showed that rimonabant, a cannabinoid 1 (CB1) receptor antagonist, significantly reduced total atheroma volume, suggesting that CB1 receptor blockade could be beneficial in ..
  52. doi Cannabinoid receptor 1 gene polymorphism and irritable bowel syndrome in the Korean population: a hypothesis-generating study
    Jae Myung Park
    Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    J Clin Gastroenterol 45:45-9. 2011
    ..We hypothesized that genetic variants of the cannabinoid receptor 1 gene (CNR1) might be associated with IBS.
  53. doi CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies
    E Zurolo
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Neuroscience 170:28-41. 2010
    ..Using immunocytochemistry, we explored the expression and cellular pattern of CBR 1 and 2 (CB1 and CB2) during prenatal human cortical development, as well as in focal malformations of cortical development ..
  54. pmc Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4
    Lina Thors
    Pharmacology Unit, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden
    PLoS ONE 5:e12275. 2010
    ....
  55. ncbi Human platelets express authentic CB₁ and CB₂ receptors
    M V Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Curr Neurovasc Res 7:311-8. 2010
    ..It seems remarkable that some of these substances have been already used in humans to treat disease states...
  56. pmc Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Chia Shan Wu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 32:693-706. 2010
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use...
  57. doi The (AAT)n repeat of the cannabinoid CB1 receptor gene influences disease progression in relapsing multiple sclerosis
    Silvia Rossi
    Dipartimento di Neuroscienze, Universita Tor Vergata, Italy
    Mult Scler 17:281-8. 2011
    ....
  58. pmc Tumour Cannabinoid CB(1) receptor and phosphorylated epidermal growth factor receptor expression are additive prognostic markers for prostate cancer
    Christopher J Fowler
    Department of Pharmacology and Clinical Neuroscience, Pharmacology, Umea University, Umea, Sweden
    PLoS ONE 5:e15205. 2010
    ....
  59. pmc Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    Beng Choon Ho
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 5224, USA
    Schizophr Res 128:66-75. 2011
    ..b>Cannabinoid receptor 1 (CB1/CNR1) is the principal brain receptor mediating marijuana effects...
  60. pmc Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease
    Jose M de Miguel-Yanes
    General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 19:2031-7. 2011
    ..We analyzed whether common variants in the gene encoding CB1, CNR1, are associated with insulin resistance, risk of type 2 diabetes (T2D) or coronary heart disease (CHD)...
  61. pmc High tumour cannabinoid CB1 receptor immunoreactivity negatively impacts disease-specific survival in stage II microsatellite stable colorectal cancer
    Sofia B Gustafsson
    Department of Pharmacology and Clinical Neuroscience, Pharmacology, Umea University, Umea, Sweden
    PLoS ONE 6:e23003. 2011
    ..In the present study, we have investigated whether CB(1) receptor immunoreactive intensity (CB(1)IR intensity) is associated with disease severity and outcome...
  62. doi PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis
    Amy D Marshall
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 71:7471-80. 2011
    ..Here, we show that upregulation of the cannabinoid receptor 1 (Cnr1/Cb1) by PAX3-FOXO1 in mouse primary myoblasts and ARMS cell lines, contributes to PAX3-FOXO1 ..
  63. pmc Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA
    Endocrinology 153:29-41. 2012
    The cannabinoid receptor type 1 (CB1) is a G protein-coupled receptor that is activated in an autocrine fashion by the endocannabinoids (EC), N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG)...
  64. pmc CNR1 genotype influences HDL-cholesterol response to change in dietary fat intake
    Heidi J Silver
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 7:e36166. 2012
    ..We previously showed that a common CNR1 haplotype, H3 (frequency 20%), is protective against the reduction in HDL-C that typically accompanies weight gain...
  65. pmc Cannabinoid receptor 1 gene and irritable bowel syndrome: phenotype and quantitative traits
    Michael Camilleri
    Clinical Enteric Neuroscience Translational and Epidemiological Research CENTER, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Gastrointest Liver Physiol 304:G553-60. 2013
    Genetic variations in metabolism of endocannabinoids and in CNR1 (gene for cannabinoid 1 receptor) are associated with symptom phenotype, colonic transit, and left colon motility in irritable bowel syndrome (IBS)...
  66. doi Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment
    Marina Mitjans
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona Institut de Biomedicina de la Universitat de Barcelona IBUB, Av Diagonal, 643 2on pis, 08028 Barcelona, Spain
    Psychopharmacology (Berl) 227:509-19. 2013
    ..The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects...
  67. ncbi Plasma membrane and lysosomal localization of CB1 cannabinoid receptor are dependent on lipid rafts and regulated by anandamide in human breast cancer cells
    Daniela Sarnataro
    Dip di Scienze Farmaceutiche, Universita degli Studi di Salerno, Italy
    FEBS Lett 579:6343-9. 2005
    In this report we show, by confocal analysis of indirect immunofluorescence, that the type-1 cannabinoid receptor (CB1R), which belongs to the family of G-protein-coupled receptors, is expressed on the plasma membrane in human breast ..
  68. ncbi CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis
    Fatima Teixeira-Clerc
    INSERM, Unité 581, Hopital Henri Mondor Creteil, F 9400 France
    Nat Med 12:671-6. 2006
    ..Here we investigated whether activation of cannabinoid CB1 receptors (encoded by Cnr1) promotes progression of fibrosis...
  69. ncbi Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level
    Patrik Löfgren
    Department of Medicine, Karolinska Institutet, M61, Karolinska University Hospital, 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 92:1555-9. 2007
    The cannabinoid receptor 1 gene (CNR1) is implicated in adipocyte function.
  70. pmc Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3
    Raphael Rozenfeld
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2311-22. 2008
    b>Cannabinoid receptor 1 (CB(1)) is an abundant G protein-coupled receptor, involved in a number of physiological processes. This receptor is localized at the plasma membrane, as well as in intracellular vesicles...
  71. doi Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations
    Michael Benzinou
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 17:1916-21. 2008
    ..Using a staged-approach, we examined the contribution of the endocannabinoid receptor 1 gene (CNR1) on obesity and body mass index (BMI) in the European population...
  72. pmc Cannabinoid receptor 1 gene association with nicotine dependence
    Xiangning Chen
    Virginia Institute for Psychiatric and Behavioral Genetics and Department of Psychiatry, Virginia Commonwealth University, 800 Leigh St, Ste 1 110, Richmond, VA 23298, USA
    Arch Gen Psychiatry 65:816-24. 2008
    The endogenous cannabinoid system has been implicated in drug addiction in animal models. The cannabinoid receptor 1 (CNR1) gene is 1 of the 2 receptors expressed in the brain...
  73. pmc The incentive salience of alcohol: translating the effects of genetic variant in CNR1
    Kent E Hutchison
    The MIND, 1101 Yale Blvd NE, Albuquerque, NM 87131, USA
    Arch Gen Psychiatry 65:841-50. 2008
    The gene that codes for cannabinoid receptor 1 (CNR1) represents an important target for investigations designed to elucidate individual differences in the etiology of alcohol dependence.
  74. pmc Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index
    Tes M Baye
    Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Pharmacogenomics 9:1647-56. 2008
    ..In randomized trials, pharmacological blockade at the level of the cannabinoid receptor 1 (CNR1) receptor not only facilitates weight reduction, but also improves insulin sensitivity and clinical ..
  75. doi Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Medical Faculty, University of Leipzig, Leipzig, Germany
    Pharmacogenomics 11:693-702. 2010
    ..Here we investigated the effects of genetic variation in the cannabinoid type 1 receptor gene (CNR1) on its mRNA expression in adipose tissue from visceral and subcutaneous depots and on the development of obesity.
  76. ncbi Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse
    P W Zhang
    Molecular Neurobiology Branch, National Institute on Drug Abuse IRP NIH, Baltimore, MD 21224, USA
    Mol Psychiatry 9:916-31. 2004
    A number of lines of evidence make the gene that encodes the G-protein-coupled CB1/Cnr1 receptor a strong candidate to harbor variants that might contribute to individual differences in human addiction vulnerability...
  77. pmc The neurobiology and evolution of cannabinoid signalling
    M R Elphick
    School of Biological Sciences, Queen Mary, University of London, London E1 4NS, UK
    Philos Trans R Soc Lond B Biol Sci 356:381-408. 2001
    ..which exerts effects in the brain by binding to a G-protein-coupled receptor known as the CB1 cannabinoid receptor...
  78. ncbi Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats
    T U Jarbe
    Allegheny University of the Health Sciences, Institute of Addiction Disorders, Department of Psychiatry, Philadelphia, PA 19102, USA
    Behav Pharmacol 9:169-74. 1998
    ..The delta-9-tetrahydrocannabinol-induced increase in circling was blocked by the central cannabinoid receptor CB1 antagonist SR 141716...
  79. ncbi Redistribution of CB1 cannabinoid receptors during evolution of cholinergic basal forebrain territories and their cortical projection areas: a comparison between the gray mouse lemur (Microcebus murinus, primates) and rat
    T Harkany
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Neuroscience 135:595-609. 2005
    Endocannabinoid signaling, mediated by presynaptic CB1 cannabinoid receptors on neurons, is fundamental for the maintenance of synaptic plasticity by modulating neurotransmitter release from axon terminals...
  80. ncbi The endocannabinoid-CB receptor system: Importance for development and in pediatric disease
    Ester Fride
    Department of Behavioral Sciences, College of Judea and Samaria, Ariel 44837, Israel
    Neuro Endocrinol Lett 25:24-30. 2004
    Endogenous cannabinoids (endocannabinoids) and their cannabinoid CB1 and CB2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism...
  81. doi Endocannabinoids affect the reproductive functions in teleosts and amphibians
    E Cottone
    Dipartimento di Biologia Animale e dell Uomo, Laboratorio di Anatomia Comparata, Universita degli Studi di Torino, Via Accademia Albertina 13, I 10123 Torino, Italy
    Mol Cell Endocrinol 286:S41-5. 2008
    ..the discovery in the brain of the bonyfish Fugu rubripes of two genes encoding for type 1 cannabinoid receptors (CB1A and CB1B), investigations on the phylogeny of these receptors have indicated that the cannabinergic system is ..
  82. doi Differential role of the hippocampal endocannabinoid system in the memory consolidation and retrieval mechanisms
    Lucas de Oliveira Alvares
    Laboratório de Psicobiologia e Neurocomputação, Departamento de Biofisica, Instituto de Biociencias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Neurobiol Learn Mem 90:1-9. 2008
    b>CB1 cannabinoid receptors are abundantly expressed in the brain, with large concentrations present in the hippocampus, a brain structure essential for memory processing...
  83. ncbi Cannabinoid receptors CB1 and CB2: a characterization of expression and adenylate cyclase modulation within the immune system
    A R Schatz
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, USA
    Toxicol Appl Pharmacol 142:278-87. 1997
    ..Northern analysis revealed approximately 6-kb transcripts for CB1 (brain-type) in mouse spleen and brain and in rat cerebellum...
  84. pmc Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily
    T Kadowaki
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106
    EMBO J 12:2929-37. 1993
    ..cerevisiae (CNR1 and CNR2)...
  85. ncbi CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide
    M Kathmann
    Institut fur Pharmakologie und Toxikologie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:421-7. 1999
    We have studied (i) the effect of antisense oligodeoxynucleotides complementary to CB1 mRNA on the CB1 receptor binding in hippocampus, striatum and cerebral cortex of the rat; (ii) the possible mechanism of action of one of the ..
  86. doi Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR
    Dean F Wong
    Radiology, Johns Hopkins University, Baltimore, MD 21287, USA
    Neuroimage 52:1505-13. 2010
    Several studies have examined the link between the cannabinoid CB1 receptor and several neuropsychiatric illnesses, including schizophrenia...
  87. ncbi Cannabinoid receptors on goldfish retinal bipolar cells: electron-microscope immunocytochemistry and whole-cell recordings
    S Yazulla
    Department of Neurobiology and Behavior, University at Stony Brook, NY 11794 5230, USA
    Vis Neurosci 17:391-401. 2000
    ..Light microscope immunocytochemistry of CB1 receptor immunoreactivity (CB1R-IR) revealed intense staining of Müller cells and weaker staining of ON bipolar cells (verified with double ..
  88. ncbi Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons
    Tibor Harkany
    Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles väg 1 A1, Karolinska Institutet, S 17177 Stockholm, Sweden
    Eur J Neurosci 18:1979-92. 2003
    ..Presynaptic action of endocannabinoids is largely mediated by type 1 cannabinoid (CB1) receptors, while fatty-acid amide hydrolase (FAAH) is involved in inactivating some endocannabinoids ..
  89. ncbi Cannabinoids modulate neuronal firing in the rat basolateral amygdala: evidence for CB1- and non-CB1-mediated actions
    Marco Pistis
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato CA, Italy
    Neuropharmacology 46:115-25. 2004
    ..High levels of CB1 cannabinoid receptors have been shown in this region, where they modulate excitatory and inhibitory synaptic ..
  90. doi Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment
    J Zarate
    Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Paseo de la Universidad 7, 01006 Vitoria, Spain
    Brain Res 1236:57-72. 2008
    ..study, we report on the application of two specific polyclonal antibodies to different intracellular domains of the CB1 cannabinoid receptor to define the expression of the neural CB1 cannabinoid receptor at the histochemical level in ..
  91. ncbi Novel cannabinol probes for CB1 and CB2 cannabinoid receptors
    A Mahadevan
    Organix, Inc, 240 Salem Street, Woburn, Massachusetts 01801, USA
    J Med Chem 43:3778-85. 2000
    The observation that the phenolic hydroxyl of THCs was important for binding to the CB1 receptor but not as critical for binding to the CB2 receptor prompted us to extend this finding to the cannabinol (CBN) series...
  92. ncbi Topical cannabinoid agonist, WIN55,212-2, reduces cornea-evoked trigeminal brainstem activity in the rat
    D A Bereiter
    Department of Surgery, Brown Medical School, Rhode Island Hospital, 222 Nursing Arts Building, Providence, RI 02903, USA
    Pain 99:547-56. 2002
    ..Corneal sensory nerves express the CB1 cannabinoid receptor and project to two spatially discrete regions of the lower brainstem, the trigeminal ..
  93. ncbi The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus
    K A Takahashi
    Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University, Kennedy Center Room 703, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Neuroscience 139:795-802. 2006
    ..Of the two cloned cannabinoid receptors, cannabinoid receptor 1 (CB1) is widely distributed in the CNS and accounts for most of the neurological effects of cannabinoids, ..
  94. ncbi Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus
    Marzena Mackowiak
    Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna Street, Poland
    Brain Res 1148:43-52. 2007
    ..On the other hand, CB1 receptor activation is known to disturb some hippocampal processes involving plastic changes, such as learning and ..
  95. pmc Inhibition of striatal dopamine release by CB1 receptor activation requires nonsynaptic communication involving GABA, H2O2, and KATP channels
    ZSUZSANNA SIDLO
    Department of Neurosurgery, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neurochem Int 52:80-8. 2008
    ..The behavioral consequences of THC or synthetic CB1R agonists include suppression of motor activity...
  96. ncbi CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, USA
    Mol Pharmacol 70:1236-45. 2006
    ..Although it is assumed that this type of effect is mediated through CB1 receptor (CB1R) antagonism, several in vitro functional studies recently have suggested non-CB1R involvement...
  97. ncbi The pharmacology of cannabinoid receptors and their ligands: an overview
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Int J Obes (Lond) 30:S13-8. 2006
    Mammalian tissues express at least two cannabinoid receptor types, CB1 and CB2, both G protein coupled. CB1 receptors are found predominantly at nerve terminals where they mediate inhibition of transmitter release...
  98. ncbi Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
    K Tsou
    Schrier Research Laboratory, Department of Psychology, Providence, RI, USA
    Neuroscience 83:393-411. 1998
    ..receptors in the adult rat brain was studied using specific purified antibodies against the amino-terminus of the CB1 receptor...
  99. ncbi Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors
    O Valverde
    Dpt Pharmacochimie Moléculaire, INSERM U266, URA 1500 CNRS, Faculte de Pharmacie, 4, avenue de l Observatoire, 75260 Paris cedex 06, France
    Eur J Neurosci 12:533-9. 2000
    b>CB1 cannabinoid receptors are widely distributed in the central nervous system where they mediate most of the cannabinoid-induced responses...
  100. pmc CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice
    Astrid Cannich
    Groups of Molecular Genetics of Behavior, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Learn Mem 11:625-32. 2004
    Cannabinoid receptors type 1 (CB1) play a central role in both short-term and long-term extinction of auditory-cued fear memory. The molecular mechanisms underlying this function remain to be clarified...
  101. doi The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists
    Kathryn A Seely
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    J Pharmacol Exp Ther 330:31-9. 2009
    ..that cannabinoids, derived from the marijuana plant (Cannabis sativa), produce similar protective effects via CB1 and CB2 receptors...

Research Grants72

  1. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    Cannabinoid (CB) type-1 receptors (CB1) in the central nervous system (CNS) mediate the psychoactive effects of delta-9-tetrahydrocannabinol, the major active constituent in marijuana...
  2. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2009
    Activation of the endocannabinoid system through CB1, CB2 and additional receptor subtypes results in the inhibition of a broad range of cancers...
  3. Virginia S Seybold; Fiscal Year: 2014
    ..degradation in the periphery reduces mechanical hypersensitivity in a murine model of bone cancer pain through CB1 and CB2 receptor-dependent mechanisms...
  4. BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)
    Emmanuel S Onaivi; Fiscal Year: 2012
    ..makes its own natural marijuana-like substances called endocannabinoids that act upon two types of receptors called CB1 and CB2 receptors have been achieved...
  5. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..CSF) endocannabinoid levels and 2) post-mortem findings of regional alterations in brain cannabinoid receptors (CB1R) in schizophrenia...
  6. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..We will also use mice that are deficient in FAAH or one of the primary cannabinoid receptors (CB1 or CB2) to test the novel hypothesis that endocannabinoids inhibit visceral pain arising from bladder inflammation ..
  7. Examination of endocannabinoid elevation and extinction learning
    JASON MICHAEL WIEBELHAUS; Fiscal Year: 2013
    ..9-THC is one of a group of exogenous cannabinoids that binds to and activates CB1 cannabinoid receptors that are widely distributed throughout the CNS...
  8. Daniele Piomelli; Fiscal Year: 2016
    ..suppresses acute and chronic pain-related responses in rodents by enhancing the intrinsic activity of anandamide at CB1-type cannabinoid receptors located outside the CNS...
  9. DONALD SIMONE; Fiscal Year: 2014
    ..Cannabinoid receptors (CB1 and CB2) are located in the periphery, as well as the central nervous system, and modulate nociception...
  10. Alexandros Makriyannis; Fiscal Year: 2016
    ..and non-covalent ligands will be utilized to obtain detailed structural information on the active sites of the CB1 and CB2 cannabinoid receptors (CBRs)...
  11. Aron H Lichtman; Fiscal Year: 2014
    ..However, THC and other CB1 receptor agonists display several cannabimimetic side effects, including marijuana-like subjective activity, that ..
  12. Subroto Ghose; Fiscal Year: 2016
    ..unreadable]9-THC), the main psychotropic constituent of cannabis, mediates its effects via cannabinoid 1 (CB1) receptors, which are among the most highly expressed receptors in the brain...
  13. Jenny L Wiley; Fiscal Year: 2016
    ..Aim 3 will characterize the pharmacokinetics of THC and will identify regional alterations in central CB1 and CB2 receptor densities and functioning and endocannabinoid levels that are associated with behavioral changes...
  14. TORBJORN U JARBE; Fiscal Year: 2016
    ..Cannabinoid receptor CB1 (CB1R) agonists and antagonists will be trained in drug discrimination using different doses, providing for in vivo ..
  15. The neuronal basis of cannabis-induced developmental deficits in the CNS
    Yasmin L Hurd; Fiscal Year: 2012
    ..We have previously found that CB1 cannabinoid receptors are selectively localized to the limbic system of the human embryo as early as week 14 of ..
  16. PATRICK DAVID SKOSNIK; Fiscal Year: 2014
    ..and associated phytocannabinoids exert their effects through the activation of central cannabinoid receptors (CB1R)...
  17. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..to bacterial, viral and parasitic infections, presumably through the central or peripheral cannabinoid receptors, CB1R or CB2R, respectively...
  18. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012
    ..Cannabinoids have been shown to mediate their effects through cannabinoid receptors CB1 and CB2...
  19. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..disorders are associated with overactive signaling specifically at the level of the CB1 receptor (gene name CNR1). The CB1 receptor has two endogenous ligands: N-arachidonylethanolamine (AEA) and 2-arachdionylglycerol (2-AG)...
  20. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..released in response to increased nociceptor activity, feeds back to inhibit such activity by acting at presynaptic CB1 receptors...
  21. BASAVARAJ S BALAPAL; Fiscal Year: 2016
    ..data suggest that ethanol administration during the synaptogenic period activates the cannabinoid type 1 (CB1R) receptor inducing neurodegeneration...
  22. Glucocorticoids and endocannabinoids in vagal complex
    Bret N Smith; Fiscal Year: 2013
    ..are thought to be released from cell membranes in a retrograde fashion, activate both cannabinoid type 1 receptors (CB1R) and transient receptor potential vanilloid type 1 (TRPV1)...
  23. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2013
    ..Metabotropic glutamate (mGlu) receptors and endocannabinoids, active at the cannabinoid type-1 (CB1) receptor, are increasingly implicated in the synaptic plasticity associated with opiate-induced conditioned place ..
  24. Regulation of presympathetic RVLM neurons by cannabinoids
    ANDREI DERBENEV; Fiscal Year: 2009
    ..Little is known about normal RVLM neuronal regulation. The G protein-coupled cannabinoid type-1 receptor (CB1R) is expressed throughout the CNS, including the RVLM. Endogenous cannabinoids (eCB), (e. g...
  25. Cannabinoid Receptor Mechanisms in Accumbal Encoding of Extinction Learning
    JOSEPH FRANCOIS RENE CHEER; Fiscal Year: 2012
    ..the neurobiological mechanisms that accompany the well-documented anti-relapse effects of cannabinoid receptor (CB1) antagonists (Fattore et al., 2007)...
  26. Role of the Endocannabinoid System in the Neurobiology of Depressive Behavior
    VINOD K YARAGUDRI; Fiscal Year: 2010
    ..The CB1 receptor, a GPCR, has recently been shown to play a critical role in neural circuitries mediating mood, motivation, ..
  27. Endogenous Cannabinoids and Brain Function
    Aron H Lichtman; Fiscal Year: 2013
    ..synthesis of putative endocannabinoids, stable and potent analogs, metabolic and synthetic enzyme inhibitors and CB1 receptor allosteric modulators...
  28. Interactions Between CB1 Receptor and DA Receptors in the Nucleus Accumbens Core
    TABAN NONE SEIF; Fiscal Year: 2012
    ..Further, cannabinoid type-1 (CB1) receptors in the NAc can also critically regulate motivated behavior...
  29. Endocannabinoids and the modulation of expectation
    JOSEPH FRANCOIS RENE CHEER; Fiscal Year: 2013
    ..by applicant): This proposal will investigate the neural mechanisms associated with the well-documented effects of CB1 receptor blockade1 on extinction processes in a key associative learning circuit...
  30. Endocannabinoid Intracellular Transporters
    Dale G Deutsch; Fiscal Year: 2010
    ..anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid receptors CB1 and CB2. Unlike most other neurotransmitters, the endocannabinoids are neutral hydrophobic molecules...
  31. Electrophysiological Assessment of Cannabinois Receptors
    Samuel A Deadwyler; Fiscal Year: 2012
    ..this paradigm in association with pharmacological manipulation of processes involved in endocannabinoid release and CB1 receptor mediated cellular processes...
  32. KENNETH P MACKIE; Fiscal Year: 2016
    ..objectives during the next five years include: (1) Obtaining a comprehensive understanding of the mechanisms of CB1 cannabinoid receptor desensitization, (2) Discerning the roles of endogenous and exogenous cannabinoids during two ..
  33. CB1R independent effects of cannabinoids on synaptic physiology in the CNS.
    Charles J Frazier; Fiscal Year: 2012
    ..agonists potentiate action potential independent release of GABA in the dentate gyrus through a cannabinoid type I (CB1) receptor independent mechanism...
  34. Central Endocannabinoid System Dysfunction and Hypertension
    Jeanne L Seagard; Fiscal Year: 2013
    ..ECBs in the NTS by examining the effects of ECBs on baroreflex-evoked sympathoinhibition and either 1) changes in CB1R binding density in the dorsal medulla, including the NTS, or 2) CB1R message using quantitative reverse ..
  35. Allosteric Modulators of CB1 Cannabinoid Receptor
    GANESHSINGH ARJUNSINGH THAKUR; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Selective CB1 cannabinoid receptor ligands have therapeutic potential for various medical conditions, including obesity, substance (e.g...
  36. Pope-Presynaptic modulation of anticholinesterase toxicity
    Carey N Pope; Fiscal Year: 2013
    ..Finally, studies in aim 4 will compare sensitivity of CB1+/+ and CB1-/- mice to acute and subacute toxicity from parathion and chlorpyrifos and evaluate possible changes in ..
  37. CB1 and DA Receptor Deletion by RNAi in Cocaine Self-Administration
    CAROLINE EVELYN BASS; Fiscal Year: 2011
    ..delivery of RNA interference (RNAi) transgenes to develop her own project focused on the knock down of D1, D2 and CB1 receptors in strategically defined brain loci, the impact this has on the reinforcing efficacy of cocaine, and how ..
  38. LEAH YU LIU; Fiscal Year: 2014
    ..We have recently generated zebrafish mutants for the two cannabinoid receptors, cnr1 and cnr2, using transcription activator-like effector nucleases (TALEN), a novel technique recently optimized for ..
  39. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..an animal model of PD) indicates that application of direct cannabinoid agonists alleviates LID via activation of CB1 cannabinoid receptors and concomitant desensitization of TRPV1 receptors through a phosphatase-operated mechanism...
  40. Lawrence J Marnett; Fiscal Year: 2016
    ..2-AG and AEA are the two best characterized endogenous ligands for the cannabinoid receptors - CB1 and CB2 - and exert a plethora of effects through these receptors...
  41. Endocannabinoid Signaling During Early Pregnancy
    Sudhansu K Dey; Fiscal Year: 2012
    ..and 2-arachidonoyglycerol (2-AG) function as endogenous ligands (endocannabinoids) for cannabinoid receptors (CB1 and CB2). CB1 and CB2 are G protein-coupled receptors...
  42. Endocannabinoid Inactivation:Plasma Membrane Uptake and Cellular Trafficking
    Dale G Deutsch; Fiscal Year: 2012
    ..anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are the major signaling molecules for the cannabinoid receptors CB1 and CB2. All neurotransmitters require an efficient mechanism to terminate their action at the receptor...
  43. JOSE OLUCHA - ALVAREZ; Fiscal Year: 2015
    ..2- arachidonoylglycerol (2-AG) is a lipid messenger of the ECS, full agonist at Cannabinoid Receptors type 1 (CB1) and type 2 (CB2)...
  44. Cannabinergic Ligands and Drugs
    Alexandros Makriyannis; Fiscal Year: 2012
    ..These include the two cannabinoid receptors (CB1, CB2), the endocannabinoid deactivating enzymes (FAAH, MGL), and the transporter system (AT)...
  45. STATUS EPILEPTICUS REORGANIZES CANNABINOID RECEPTORS
    ROBERT JOHN DELORENZO; Fiscal Year: 2010
    The central nervous system cannabinoid receptor (CB1) is one of the most abundant G-Protein coupled receptors in brain and mediates many of the effects of cannabinoid substances on neuronal function...
  46. MAGL Inhibition in Prevention and Treatment of Alzheimer's Disease
    Chu Chen; Fiscal Year: 2012
    ..processes and capable of modulating synaptic transmission and plasticity by activation of the cannabinoid receptor (CB1R), a predominantly expressed type of cannabinoid receptors in the brain...
  47. Activity Dependence of Endocannabinoid Signaling
    MICHAEL MYOGA; Fiscal Year: 2010
    ..b>CB1R signaling can induce both short-term and long-term depression (STD and LTD)...
  48. Endocannabinoid Metabolic Enzymes: Structure, Function, In Vivo Inhibition
    Benjamin F Cravatt; Fiscal Year: 2013
    ..2-AG) are lipid transmitters that activate the central and peripheral cannabinoid receptors (CB1 and CB2, respectively) to regulate a broad range of physiological processes, including pain sensation, inflammation,..
  49. Aggregation Properties of Hemopressin
    Surendra Kumar Nayak; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The endocannabinoid system consists of two cannabinoid receptors CB1 and CB2, which are G-protein coupled receptors and activated by mainly lipidic compounds...
  50. Jenny L Wiley; Fiscal Year: 2016
    ..The long-term objective of this application is to understand the role that CB1, CB2 and orphan G-protein-coupled receptors play in these processes...
  51. Alexandros Makriyannis; Fiscal Year: 2016
    ..order to identify the pharmacophoric profiles of key compound classes that directly modulate the functions of the CB1 and CB2 cannabinoid receptors (CBRs)...
  52. A novel cannabinoid receptor in cortical nerve terminals
    Stephen M Smith; Fiscal Year: 2011
    ..This work will define the tools necessary to dissect the relative contributions of CaSR and CB1 to cannabinoid modulation of synaptic transmission in the brain...
  53. KENNETH P MACKIE; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): CB1 cannabinoid receptors mediate the psychoactivity of cannabis, the most commonly abused illicit drug, and are also attractive therapeutic targets...
  54. Imaging Brain Cannabinoid Receptors in Cannabis Dependence, Withdrawal and Abstin
    PATRICK DAVID SKOSNIK; Fiscal Year: 2012
    ..Exogenous cannabinoids produce their psychoactive effects via the activation of brain CB1 receptors (CB1R). Repeated exposure to cannabis and CB1R agonists is associated with the development of tolerance and dependence...
  55. Andrea Giuffrida; Fiscal Year: 2015
    ..Recent studies, however, have challenged this hypothesis: for example, drugs aimed at blocking cannabinoid CB1 receptor activity have failed as antipsychotics in clinical trials...
  56. Cannabinoid-induced apoptosis of immune cells
    Mitzi Nagarkatti; Fiscal Year: 2002
    ..The discovery of the existence of CB1 and CB2 cannabinoid receptors and the isolation of endogenous ligands have raised questions on the physiological ..
  57. Brain Cannabinoid Signaling: Selectivity and Adaptation
    Laura J Sim Selley; Fiscal Year: 2010
    ..the psychoactive component of marijuana, produces a variety of effects by activating cannaibinoid CBl receptors (CB1R) in specific CNS regions...
  58. Colleen Cosgrove Hegg; Fiscal Year: 2014
    ..Currently, there are no medications available to treat cannabinoid addiction;however, CB1 antagonists are currently being developed as potential therapeutic agents...
  59. CB1 Mediation of Cerebellum Versus Forebrain-Dependent Associative Learning
    PATRICK DAVID SKOSNIK; Fiscal Year: 2013
    ..The cerebellum arguably contains the highest density of CB1 receptors in the brain...
  60. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..have recently obtained in vitro and in vivo proof-of-concept data that ajulemic acid, a non-psychotropic nanomolar CB1/ CB2 agonist is highly effective in preventing skin and lung fibrosis in a mouse bleomycin model of scleroderma and ..
  61. The regulation of cannabinoid receptors in microglial cells during HIV infection
    CATALIN FILIPEANU; Fiscal Year: 2012
    ..These actions are mediated by interactions with at least three specific receptors (CB1R, CB2R and GPR55) that are expressed in the central nervous system (CNS)...
  62. John W Wiley; Fiscal Year: 2016
    ..role in pain transmission and the TRPV1 receptor is known to be regulated by endocannabinoids (CB) acting on CB1 receptors which inhibit TRPV1 function...
  63. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..Cannabinoid receptors (CBR) are on cholinergic neurons in the brain stem, stomach and colon. A CB1 antagonist, rimonabant, is effective in induction of weight loss;however, the mechanism of this benefit is unclear...
  64. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    The overall goals of this 4 year research plan are two-fold: (a) to characterize the role of cannabinoid receptors CB1 and CB2 in the modulation of T-cell function by endogenous eicosinoid-like cannabinoids; and (b) to elucidate the ..
  65. Cannabinoid Receptors and Cerebrovascular Function
    Cecilia Hillard; Fiscal Year: 2006
    ..In addition, we hypothesize that endocannabinoids produce vasodilation via vascular smooth muscle (VSM) CB1 cannabinoid receptor activation...
  66. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..It is known that marijuana suppresses glutamate release in vitro by activating cannabinoid CB1 receptors...
  67. Cannabinoids and Central Neuronal Activity
    Paul Schweitzer; Fiscal Year: 2005
    ..Cannabinoids effects in brain are mediated via specific receptors (CB1), and it has now become clear that marijuana interacts with a naturally occuring physiological system of endogenous ..
  68. Development of Peripherally-acting Cannabinoid 1 Receptor Ligands
    Igor Spigelman; Fiscal Year: 2010
    ..The targets of cannabinoids may be defined by the distribution of two cloned subtypes of cannabinoid receptors, CB1R and CB2R...
  69. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    Cannabinoid CB1 receptors in the CNS mediate psychoactive effects of marijuana and are a critical component of the endogenous cannabinoid system, which is involved in motivation and reward, motor control, appetite, learning and memory, ..
  70. A calcium/calcineurin signaling cascade regulates neuronal cannabinoid receptors
    Mary Lou Vallano; Fiscal Year: 2009
    ..and calmodulin-dependent phosphatase, calcineurin, regulates the transcription of type 1 cannabinoid receptors (CB1) in neurons. CB1 is the primary target for plant and endogenous cannabinoids in mammalian brain...
  71. Cannabinoid Receptors and Novel Antiglaucoma Drugs
    Zhao Hui Song; Fiscal Year: 2010
    ..In the previous funding period, we have established that CB1 and CB2 cannabinoid receptors are expressed on the trabecular meshwork (TM) cells, and cannabinoid agonists enhance ..
  72. Cannabinoid Antagonist Influences on Ingestive Behavior
    JAMES KOCH; Fiscal Year: 2003
    ..inverse agonists), essentially block activity at the cannabinoid receptors located in the central nervous system (CB1 receptors)...