Genomes and Genes
Gene Symbol: CLU
Alias: AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin, aging-associated protein 4, apolipoprotein J, complement cytolysis inhibitor, complement lysis inhibitor, complement-associated protein SP-40,40, ku70-binding protein 1, sulfated glycoprotein 2, testosterone-repressed prostate message 2
Publications263 found, 100 shown here
- Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's diseaseDenise Harold
Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
Nat Genet 41:1088-93. 2009..significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8))...
- Clusterin/apolipoprotein J in human aging and cancerIoannis P Trougakos
Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
Int J Biochem Cell Biol 34:1430-48. 2002Clusterin/Apolipoprotein J (ApoJ) is a heterodimeric highly conserved secreted glycoprotein being expressed in a wide variety of tissues and found in all human fluids...
- ClusterinSteve E Jones
Retinitis Pigmentosa Research Unit, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, The Rayne Institute, St Thomas Hospital, Londoon SE1 7EH, UK
Int J Biochem Cell Biol 34:427-31. 2002b>Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease...
- Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
- Genetics of clusterin isoform expression and Alzheimer's disease riskI Fang Ling
Department of Physiology and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
PLoS ONE 7:e33923. 2012..and secreted proteins, respectively, we compared their expression; for both CLU1 and CLU2 transfected cells, clusterin is present in the secretory pathway, accumulates in the extracellular media, and is similar in size to clusterin ..
- Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stabilityKwan Bok Lee
School of Bioscience and Biotechnology, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
Biochem Biophys Res Commun 366:905-9. 2008b>Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis...
- Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's diseaseYao Yao Xing
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
J Alzheimers Dis 29:515-9. 2012Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown...
- Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer diseaseMadhav Thambisetty
King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
Arch Gen Psychiatry 67:739-48. 2010..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
- Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adultsMEREDITH N BRASKIE
Laboratory of Neuro Imaging, Department of Neurology, University of California, School of Medicine, Los Angeles, California 90095, USA
J Neurosci 31:6764-70. 2011..A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1...
- Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer riskKarolien Bettens
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
Mol Neurodegener 7:3. 2012We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an ..
- Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical studyP Giannakopoulos
Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
Acta Neuropathol 95:387-94. 1998b>Clusterin is a secreted glycoprotein that is expressed in response to tissue injury both in peripheral organs and in the brain...
- Potential protective role of apoprotein J (clusterin) in atherogenesis: binding to enzymatically modified low-density lipoprotein reduces fatty acid-mediated cytotoxicityMargarethe Schwarz
Institute of Medical Microbiology and Hygiene, Hochhaus am Augustusplatz, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
Thromb Haemost 100:110-8. 2008..Apoprotein J (ApoJ) alias clusterin is a multifunctional glycoprotein with cytoprotective and anti-inflammatory properties...
- Clusterin (CLU) and prostate cancerFederica Rizzi
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno 39 43100 Parma, Italy
Adv Cancer Res 105:1-19. 2009The role of clusterin (CLU) in prostate tumorigenesis is probably the most highly controversial, with evidence that CLU expression is increased or decreased in different cancer models...
- Apolipoprotein J and leptin levels in patients with coronary heart diseaseMaria V Poulakou
Department of Experimental Surgery and Surgical Research N S Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece
In Vivo 22:537-42. 2008Preliminary data suggest that apolipoprotein J (ApoJ) may play a role in the development and progression of atherosclerosis. Leptin, an adipose tissue hormone, exerts important cardiovascular effects...
- Serum clusterin levels are not increased in presymptomatic Alzheimer's diseaseLinda Ijsselstijn
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
J Proteome Res 10:2006-10. 2011Increased plasma levels of clusterin have recently been found to be associated with severity and progression in Alzheimer's disease (AD)...
- The clusterin paradigm in prostate and breast carcinogenesisFederica Rizzi
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Parma, Italy
Endocr Relat Cancer 17:R1-17. 2010The biological functions of clusterin (CLU, also known as ApoJ, SGP2, TRPM-2, CLI) have been puzzling the researchers since its first discovery in the early 80's...
- Identification of clusterin domain involved in NF-kappaB pathway regulationAbdellatif Essabbani
INSERM, U567, Institut Cochin, 75014 Paris, France
J Biol Chem 285:4273-7. 2010b>Clusterin (CLU) is a ubiquitous protein that has been implicated in tumorigenesis, apoptosis, inflammation, and cell proliferation. We and others have previously shown that CLU is an inhibitor of the NF-kappaB pathway...
- Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J/clusterin in epithelial cellsK B Reddy
Department of Cell Biology, Cleveland Clinic Research Institute, Ohio 44195 5245, USA
Biochemistry 35:6157-63. 1996b>Apolipoprotein J (apoJ)/clusterin was first identified as an 80 kDa secretory glycoprotein present in most body fluids. It has been implicated in a variety of physiological processes including cellular differentiation and apoptosis...
- Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interKaren L Grogg
Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Surg Pathol 28:988-98. 2004..Based on observations that clusterin is expressed in benign follicular dendritic cells, clusterin expression in 32 dendritic cell tumors was ..
- Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgenHideaki Miyake
Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan hideakimiyake
Prostate 61:318-23. 2004..the effect of oxidative stress on cell injury using androgen-dependent human prostate cancer LNCaP cells overexpressing clusterin, which has been shown to play crucial roles in the acquisition of resistance to several apoptotic stimuli.
- CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factorKonstantin S Leskov
Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44109, USA
J Biol Chem 286:40083-90. 2011Expression of the clusterin (CLU) gene results in the synthesis of a conventional secretory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set of intracellular isoforms, appearing in the ..
- Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluidD E Jenne
Institut de Biochimie, Universite de Lausanne, Switzerland
Proc Natl Acad Sci U S A 86:7123-7. 1989..The protein, which we have designated complement cytolysis inhibitor (CLI), has a molecular mass of 70 kDa and consists of two nonidentical, disulfide-linked subunits of ..
- Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cellsA E Caccamo
Cell Death Differ 12:101-4. 2005
- Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cellsIoannis P Trougakos
Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Ave, Athens, 11635, Greece
Biogerontology 7:375-82. 2006Clusterin/Apolipoprotein J (CLU) is a cellular senescence biomarker implicated in several physiological processes. In this work we have investigated CLU expression and function in human haematopoietic cells...
- Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritisValerie Devauchelle
Institut Cochin, Departement d Immunologie, 27 rue du Faubourg Saint Jacques, 75674 Paris Cedex 14, France
J Immunol 177:6471-9. 2006..Among the set of genes identified as a molecular signature of RA, clusterin (clu) was one of the most differentially expressed...
- The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structuresJustin J Yerbury
School of Biological Sciences, University of Wollongong, Wollongong, Australia
FASEB J 21:2312-22. 2007b>Clusterin is an extracellular chaperone present in all disease-associated extracellular amyloid deposits, but its roles in amyloid formation and protein deposition in vivo are poorly understood...
- Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systemsL Kirszbaum
Department of Veterinary Preclinical Sciences, University of Melbourne, Victoria, Australia
EMBO J 8:711-8. 1989..The precise role of SP-40,40 is not known in either blood or semen but the present findings document an intriguing link between the immune and the reproductive systems...
- Apolipoprotein J expression in human ocular surface epitheliumK Nishida
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
Invest Ophthalmol Vis Sci 37:2285-92. 1996b>Apolipoprotein J (apoJ) expression has been detected in various mouse mucosal epithelial cells, as well as in the human ciliary body, retina, vitreous humor, and aqueous humor...
- Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smokeStefano Carnevali
Department of Oncology, Haematology, and Pulmonology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Am J Respir Crit Care Med 174:393-9. 2006..b>Clusterin is a widely distributed protein with many functions, including cellular protection in response to oxidative ..
- Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivationHakryul Jo
Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
Mol Cell Biol 28:4285-99. 2008..use of biochemical purification, we reveal that cancer cell-secreted insulin-like growth factor 1 (IGF-1) and clusterin, an extracellular stress protein, constitute this regulatory system...
- Clusterin: the intriguing guises of a widely expressed glycoproteinD E Jenne
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
Trends Biochem Sci 17:154-9. 1992The glycoprotein clusterin has recently entered the scientific arena in diverse guises...
- Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progressionSaverio Bettuzzi
Dipartimento di Medicina Sperimentale, Universita di Parma, Via Volturno, 39 43100 Parma, Italy
Oncogene 21:4328-34. 2002b>Clusterin is a highly conserved, widely distributed glycoprotein whose biological significance is still debated...
- Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarctionIoannis P Trougakos
Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
Exp Gerontol 37:1175-87. 2002Clusterin/apolipoprotein J (hereafter ApoJ) is a conserved secreted glycoprotein expressed by a wide array of tissues and being implicated in several physiological processes...
- Synthesis and functional analyses of nuclear clusterin, a cell death proteinKonstantin S Leskov
Department of Radiation Oncology, Laboratory of Molecular Stress Responses, Ireland Comprehensive Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4942, USA
J Biol Chem 278:11590-600. 2003Nuclear clusterin (nCLU) is an ionizing radiation (IR)-inducible protein that binds Ku70, and triggers apoptosis when overexpressed in MCF-7 cells. We demonstrate that endogenous nCLU synthesis is a product of alternative splicing...
- Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activityGiorgia Santilli
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1N, United Kingdom
J Biol Chem 278:38214-9. 2003b>Apolipoprotein J/clusterin is an enigmatic protein highly regulated in inflammation, apoptosis, and cancer. Despite extensive studies, its biological function has remained obscure...
- Alterations in expression, proteolysis and intracellular localizations of clusterin in esophageal squamous cell carcinomaHong Zhi He
National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
World J Gastroenterol 10:1387-91. 2004To investigate biogenesis and intracellular localizations of clusterin to elucidate the potential molecular mechanisms implicated in tumorigenesis of esophageal mucosa.
- Differential effects of clusterin/apolipoprotein J on cellular growth and survivalIoannis P Trougakos
Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Ave, Athens 11635, Greece
Free Radic Biol Med 38:436-49. 2005The secreted clusterin/apolipoprotein J (CLU) protein form is a ubiquitously expressed heterodimeric glycoprotein which is differentially regulated in many severe physiological disturbance states including cell death, ageing, cancer ..
- Clusterin inhibits apoptosis by interacting with activated BaxHonglai Zhang
Laboratory of Molecular Signaling and Apoptosis, Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
Nat Cell Biol 7:909-15. 2005b>Clusterin is an enigmatic glycoprotein that is overexpressed in several human cancers such as prostate and breast cancers, and squamous cell carcinoma...
- Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cellsAlessandro E Caccamo
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno Parma, Italy
J Cell Physiol 207:208-19. 2006b>Clusterin (CLU), whose role is still debated, is differentially regulated in several patho-physiological processes and invariably induced during apoptosis...
- Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated formsA M Nilselid
Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
Neurochem Int 48:718-28. 2006b>Clusterin is suggested to be involved in the pathogenesis of Alzheimer's disease...
- Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathwayTeh Ying Chou
Institute of Clinical Medicine, National Yang Ming University, Taiwan
Cell Signal 21:704-11. 2009The ubiquitously expressed glycoprotein Clusterin (CLU) is implicated in diverse cellular processes, yet its genuine molecular function remains undefined...
- Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathwaysEirini Balantinou
National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas Constantinou Avenue, Athens, Greece
Free Radic Biol Med 46:1267-74. 2009Clusterin/apolipoprotein J (CLU) is a secreted glycoprotein associated with many severe physiological disturbances that represent states of increased oxidative stress, such as aging, cancer, atherosclerosis, diabetes, and renal and ..
- Clusterin: a forgotten player in Alzheimer's diseaseTapio Nuutinen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Brain Res Rev 61:89-104. 2009Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains several amphipathic and coiled-coil alpha-helices, typical characteristics of small heat shock proteins...
- Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's diseaseJean Charles Lambert
INSERM U744, Lille, France
Nat Genet 41:1094-9. 2009..Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7...
- Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinomaLi Ru He
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
Cancer Sci 100:2354-60. 2009b>Clusterin (CLU) is frequently overexpressed and correlates closely with chemotherapy and radiotherapy resistance and poor prognosis in many human cancers...
- Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteinsFederica Rizzi
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
Adv Cancer Res 104:9-23. 2009b>Clusterin (CLU) has kept many researchers engaged for a long time since its first discovery and characterization in the attempt to unravel its biological role in mammals...
- The role of clusterin (CLU) in malignant transformation and drug resistance in breast carcinomasMaximino Redondo
Department of Biochemistry, Hospital Costa del Sol, CIBER Epidemiología y Salud Pública, Universidad de Malaga, Marbella, Spain
Adv Cancer Res 105:21-43. 2009..Secretory clusterin (sCLU) is an extracellular chaperone that has been functionally implicated in DNA repair, cell-cycle regulation, ..
- Regulation of clusterin expression in human cancer via DNA methylationAlfonso Serrano
Department of Immunology, Hospital Clinico Universitario, Campus Universitario Teatinos, Malaga, Spain
Tumour Biol 30:286-91. 2009b>Clusterin has attracted much recent attention because of its association with tumorigenesis and the progression of human carcinomas...
- Replication of CLU, CR1, and PICALM associations with alzheimer diseaseMinerva M Carrasquillo
Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA
Arch Neurol 67:961-4. 2010To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease.
- Association of the clusterin gene polymorphisms with type 2 diabetes mellitusMakoto Daimon
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata 990 9585, Japan
Metabolism 60:815-22. 2011The association of the clusterin (CLU) gene polymorphism (single nucleotide polymorphisms [SNPs] 1-4: rs1532278, rs1532277, rs2279590, and rs2279591, respectively) with type 2 diabetes mellitus was examined using a population of the ..
- The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levelsBrit Maren M Schjeide
Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Arch Gen Psychiatry 68:207-13. 2011Two recent and simultaneously published genome-wide association studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel ..
- Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentrationBritta Schürmann
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
J Alzheimers Dis 25:421-4. 2011A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies...
- Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancerMasaki Shiota
The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada
Mol Cancer Res 9:1755-66. 2011b>Clusterin is a stress-activated, cytoprotective chaperone that confers broad-spectrum treatment resistance in cancer...
- GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancerN Li
Department of Urologic Sciences, The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
Oncogene 32:1933-42. 2013Expression of clusterin (CLU) closely correlates with the regulation of apoptosis in cancer...
- Tumor-derived secretory clusterin induces epithelial-mesenchymal transition and facilitates hepatocellular carcinoma metastasisCun Wang
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China
Int J Biochem Cell Biol 44:2308-20. 2012..Twenty tumor-derived proteins were identified through human specific peptides. Secretory clusterin (sCLU), which was significantly upregulated during cancer progression and metastasis, was chosen for further ..
- Unglycosylated clusterin variant accumulates in the endoplasmic reticulum and induces cytotoxicitySang Wook Kang
Graduate School, University of Ulsan College of Medicine, Seoul, Republic of Korea
Int J Biochem Cell Biol 45:221-31. 2013b>Clusterin is a stress-responsive and highly glycosylated secretory protein that plays cytoprotective role in most body fluids...
- Genetic variation in clusterin gene and Alzheimer's disease risk in Han ChineseJin Tai Yu
College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
Neurobiol Aging 34:1921.e17-23. 2013Clusterin gene (CLU), also known as apolipoprotein J (ApoJ), is a strong candidate gene for late-onset Alzheimer's disease (LOAD) according to the Alzgene database...
- The role of clusterin in amyloid-β-associated neurodegenerationRahul S Desikan
Department of Radiology, University of California, San Diego, La Jolla
JAMA Neurol 71:180-7. 2014Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well understood.
- Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J)N H Choi-Miura
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo
J Biochem 112:557-61. 1992..The unique structure could be related to the functions of SP-40,40...
- Apolipoprotein J: structure and tissue distributionH V de Silva
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio 45267 0575
Biochemistry 29:5380-9. 1990..ApoJ appears to be the human analogue of a rat protein present in high concentrations in the testis, sulfated glycoprotein 2. ApoJ mRNA (1.9 kb) is expressed in all but one tissue examined...
- Local synthesis of apolipoprotein J in the eyeD J Reeder
Department of Ophthalmology, University of Cincinnati College of Medicine, OH, USA
Exp Eye Res 60:495-504. 1995b>Apolipoprotein J (apoJ), a secretory glycoprotein known to transport lipids and to regulate terminal complement function, is present in the human eye in both aqueous and vitreous, as well as in the retina...
- Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegenerationP Wong
Department of Biochemistry, University of Ottawa, Canada
Eur J Biochem 221:917-25. 1994The TRPM-2/clusterin gene and its cognate protein has been characterized in a number of species...
- Apolipoprotein J is associated with paraoxonase in human plasmaG J Kelso
Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Ohio 45267
Biochemistry 33:832-9. 1994b>Apolipoprotein J (apoJ)-containing high-density lipoproteins (HDL), isolated from human plasma by immunoaffinity chromatography, are associated with apoAI and a protein of approximately 44 kDa...
- Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) geneT M Fink
Deutsches Krebsforschungszentrum, Schwerpunkt Angewandte Tumorvirologie 06, Heidelberg, Germany
Genomics 16:526-8. 1993b>Clusterin (gene symbol: CLI) is a post-translationally nicked, two-chain plasma and tissue glycoprotein of 80 kDa...
- The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complexJ Ghiso
Department of Pathology, New York University Medical Center, NY 10016
Biochem J 293:27-30. 1993..The protein was unmistakably identified as SP-40,40 or ApoJ, a cytolytic inhibitor and lipid carrier, by means of amino acid sequence and immunoreactivity with specific ..
- Clusterin (Apo J) protects against in vitro amyloid-beta (1-40) neurotoxicityL N Boggs
Lilly Research Laboratories, CNS Research Division, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Neurochem 67:1324-7. 1996b>Clusterin is a secreted glycoprotein that is markedly induced in many disease states and after tissue injury...
- Identification and characterization of glycosylation sites in human serum clusterinJ T Kapron
W Alton Jones Cell Science Center, Lake Placid, New York 12946, USA
Protein Sci 6:2120-33. 1997b>Clusterin is a ubiquitous, heterodimeric glycoprotein with multiple possible functions that are likely influenced by glycosylation...
- Clusterin has chaperone-like activity similar to that of small heat shock proteinsD T Humphreys
Department of Biological Sciences, The University of Wollongong, Northfields Avenue, Wollongong, New South Wales 2522, Australia
J Biol Chem 274:6875-81. 1999b>Clusterin is a highly conserved protein which is expressed at increased levels by many cell types in response to a broad variety of stress conditions. A genuine physiological function for clusterin has not yet been established...
- Isolation of Ku70-binding proteins (KUBs)C R Yang
Department of Radiation Oncology and Department of Pharmacology and the Ireland Cancer Center, Laboratory of Molecular Stress Responses, Case Western Reserve University, BRB 326 East, 10900 Euclid Avenue, Cleveland, OH 44106 4942, USA
Nucleic Acids Res 27:2165-74. 1999..Sequence analyses revealed KUB1 to be apolipoprotein J (apoJ), also known as X-ray-inducible transcript 8 (XIP8), testosterone-repressed prostate message-2 (TRPM-2) ..
- Clusterin is a secreted mammalian chaperoneM R Wilson
Dept of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW Australia 2522
Trends Biochem Sci 25:95-8. 2000
- Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent stateS Poon
Department of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
Biochemistry 39:15953-60. 2000We recently reported that the ubiquitous, secreted protein clusterin has chaperone activity in vitro [Humphreys et al. (1999) J. Biol. Chem. 274, 6875-6881]...
- Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapyLaura V July
The Prostate Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Prostate 50:179-88. 2002..Testosterone-repressed prostate message-2 (TRPM-2) encodes the anti-apoptotic protein clusterin, which is upregulated in response to cellular compromise as observed in normal and malignant tissues undergoing ..
- Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxidePatrick Dumont
Unit of Cellular Biochemistry and Biology, Department of Biology, The University of Namur FUNDP, Belgium
Cell Stress Chaperones 7:23-35. 2002..deletion, and an increase in the steady-state level of several senescence-associated genes such as apolipoprotein J (apo J). Apo J has been described as a survival gene against cytotoxic stress...
- Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathiesKensuke Sasaki
Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Acta Neuropathol 104:225-30. 2002Clusterin/apolipoprotein J protein expression in cases with "alpha-synucleinopathies", such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), was investigated using an immunohistochemical ..
- Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independentTingan Chen
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Cancer Res 64:7412-9. 2004b>Clusterin is a widely expressed glycoprotein that has been paradoxically observed to have both pro- and antiapoptotic functions...
- Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factorTracy Criswell
Department of Radiation Oncology and Program in Molecular and Cellular Basis of Disease, Laboratory of Molecular Stress Responses, Case Comprehensive Cancer Center, Cleveland, Ohio 44106 7285, USA
J Biol Chem 280:14212-21. 2005Secretory clusterin protein (sCLU) is a general genotoxic stress-induced, pro-survival gene product implicated in aging, obesity, heart disease, and cancer...
- Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese femalesYoshikazu Miwa
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
Biochem Biophys Res Commun 331:1587-93. 2005b>Clusterin has been implicated in lipid metabolism and atherogenesis, however, the influence of genetic variation has not been examined in Japanese...
- Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progressionDan Xie
Department of Clinical Oncology, The University of Hong Kong, Room 109, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
World J Gastroenterol 11:3285-9. 2005To investigate the expression pattern of clusterin in colorectal adenoma-carcinoma-metastasis series, and to explore the potential role of clusterin in multistage colorectal tumorigenesis and progression.
- Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancerB Shannan
Department of Dermatology, The Saarland University Hospital, Homburg 66421, Germany
Cell Death Differ 13:12-9. 2006b>Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells...
- Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cellsPaola Strocchi
Department of Pharmacology, University of Bologna, Bologna 40126, Italy
Neurobiol Aging 27:1588-94. 2006Clusterin/apolipoprotein J is a multifunctional protein up-regulated during various pathophysiological states...
- Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle controlB Shannan
Department of Dermatology, The Saarland University Hospital, Building 18, Homburg Saar 66421, Germany
J Mol Histol 37:183-8. 2006The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival...
- Differential regulation of clusterin and its isoforms by androgens in prostate cellsDawn R Cochrane
Department of Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Biol Chem 282:2278-87. 2007b>Clusterin mRNA levels were shown to increase dramatically in rat ventral prostate following castration, and clusterin was therefore originally thought to be repressed by androgens...
- Clusterin expression in normal mucosa and colorectal cancerClaus Lindbjerg Andersen
Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, DK8200 Aarhus N, Denmark
Mol Cell Proteomics 6:1039-48. 2007The gene Clusterin is a target for cancer therapy in clinical trials. The indication for intervention is up-regulated Clusterin expression...
- Stress-induced retrotranslocation of clusterin/ApoJ into the cytosolPhilippe Nizard
UMR6026 CNRS Université de Rennes1, Intracellular Protein Homeostasis, IFR 140, Campus de Beaulieu, Bat 13, 35042 Rennes Cedex, France
Traffic 8:554-65. 2007b>Clusterin is a usually secreted glycoprotein with chaperone properties...
- Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesisRoberta M Moretti
Institute of Endocrinology, University of Milan, Milan, Italy
Cancer Res 67:10325-33. 2007Besides a fully processed, secreted form of clusterin (sCLU), an alternative proapoptotic form of the protein targeting the nucleus (nCLU) was recently described...
- Increased clusterin expression in Fuchs' endothelial dystrophyUla V Jurkunas
Schepens Eye Research Institute, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 49:2946-55. 2008To investigate the differential expression of the glycoprotein clusterin/apoJ (CLU) in normal and Fuchs' endothelial dystrophy (FED) corneal endothelium and to compare the expression of various forms of CLU in normal and FED tissue.
- Clusterin is epigenetically regulated in prostate cancerHanna E Rauhala
Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland
Int J Cancer 123:1601-9. 2008..Further studies revealed that clusterin is methylated in the TRAMP-C2 cell line, as well as in the human prostate cancer cell line LNCaP...
- Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancerDong Choon Park
Department of Obstetrics and Gynecology, Saint Vincent s Hospital, The Catholic University of Korea, Suwon, Republic of Korea
Neoplasia 10:964-72. 2008..from five long-term (>8 years) and five short-term (<2 years) ovarian cancer survivors and identified clusterin as one of the genes that were significantly up-regulated in short-term survivors...
- Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complexIoannis P Trougakos
Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
Clin Cancer Res 15:48-59. 2009Secretory clusterin (sCLU)/apolipoprotein J is an extracellular chaperone that has been functionally implicated in DNA repair, cell cycle regulation, apoptotic cell death, and tumorigenesis...
- Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cellsFederica Rizzi
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
J Cell Physiol 219:314-23. 2009The Clusterin (CLU) gene produces different forms of protein products, which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis...
- Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cellsFu Tien Liao
Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan, Republic of China
J Gen Virol 90:1124-34. 2009..HCC) cell line Huh7, which stably expresses HDAgs, was differentially screened and the results showed that clusterin gene expression was enhanced. The mechanisms for HDAg-mediated clusterin gene upregulation were investigated...
- Roles of clusterin in progression, chemoresistance and metastasis of human ovarian cancerLi Wei
Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, People s Republic of China
Int J Cancer 125:791-806. 2009b>Clusterin (CLU) is a multivalent glycoprotein with ubiquitous tissue distribution...
- A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndromeAnne lie Ståhl
Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
Mol Immunol 46:2236-43. 2009A novel heterozygous mutation in the clusterin gene, nucleotide position A1298C (glutamine>proline Q433P), was detected in exon 7 of a child with recurrent hemolytic uremic syndrome (HUS)...
- Clusterin as a diagnostic and prognostic marker for transitional cell carcinoma of the bladderSahar M Hazzaa
Clinical Pathology Department, Tanta University, Tanta, Egypt
Pathol Oncol Res 16:101-9. 2010We investigated the feasibility of profiling and measuring the concentration of clusterin in urine and serum for individuals with transitional cell carcinoma (TCC) of the bladder and comparing it with nontumor controls...
- Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein foldingAmy Wyatt
School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
Adv Cancer Res 104:89-114. 2009The function(s) of clusterin may depend upon its topological location. A variety of intracellular "isoforms" of clusterin have been reported but further work is required to better define their identity...
- CLU and colon cancer. The dual face of CLU: from normal to malignant phenotypeP Mazzarelli
Department of Biopathology, Institute of Anatomic Pathology, University of Rome Tor Vergata, 00133 Rome, Italy
Adv Cancer Res 105:45-61. 2009..b>Clusterin (CLU) is a pleiotropic protein with a broad range of functions...
- Clusterin (CLU) and lung cancerF Panico
Department of Oncology, Hematology and Respiratory Diseases, Section of Respiratory Diseases, University of Modena and Reggio Emilia, 41100 Modena, Italy
Adv Cancer Res 105:63-76. 2009..Several in vitro studies have examined the role of Clusterin (CLU) in carcinogenesis, lung cancer progression, and response to chemo- and radiotherapy...
- Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cellsAmina Zoubeidi
The Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
Mol Cancer Res 8:119-30. 2010Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast ..
- Genetic variability in CLU and its association with Alzheimer's diseaseRita J Guerreiro
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 5:e9510. 2010..large genome wide association studies in Alzheimer disease (AD) have identified variants in three different genes (CLU, PICALM and CR1) as being associated with the risk of developing AD...
- Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarraysJ Bi
Laboratory of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
Neoplasma 57:191-7. 2010b>Clusterin (CLU) is expressed in a wide variety of human tissues and fluids. Overexpression of cytoplasmic clusterin (sCLU) has been implicated in cancer development and progression...
- Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypesGyungah Jun
Department of Medicine, Boston University, USA
Arch Neurol 67:1473-84. 2010To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.
- MICHAEL PATRICK MURPHY; Fiscal Year: 2016..Critical limb ischemia (CLI) results in at least 50,000 amputations annually, with a cost estimated at $4.3 billion/year...
- Kenneth Rosenfield; Fiscal Year: 2016..to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for assessing comparative effectiveness...
- Flora Sandra Siami; Fiscal Year: 2016..to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for assessing comparative effectiveness...
- Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative CellsErik J Woods; Fiscal Year: 2010..universal donor, cell therapy for an advanced form of peripheral artery disease termed "critical limb ischemia" (CLI). The major problem facing CLI patients is lack of proper circulation to the extremities...
- Laura J Suggs; Fiscal Year: 2015..This end result, termed critical limb ischemia (CLI), is treated surgiclly or endoscopically in an effort to enhance blood flow to the limb...
- Raj Kishore; Fiscal Year: 2015DESCRIPTION (provided by applicant): Critical limb ischemia (CLI) imposes a major public health burden, resulting in high rates of death and disability. Thus far no medical therapy has been shown to ameliorate CLI...
- RAYMOND QUEZON MIGRINO; Fiscal Year: 2015..Among many therapeutic cargos that can be conjugated to NLs, clusterin (also known as apolipoprotein J) has promising potential to protect against amyloid protein cell injury...
- Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and CliJOAN MARIE CRANMER; Fiscal Year: 2010..NEUROTOXICOLOGY 26 will focus on common mechanisms in neurological disease and the role of environmental exposures and gene-environment interactions in the development of neurological disease and disorders. ..
- Robyn A Honea; Fiscal Year: 2015..gene by environment interactions, we have identified several candidate genes associated with AD risk (BDNF, APOE, CLU, PICALM, CR1, TOMM40) 21, 22, and will take them through a three-step process...
- Sanford A Stass; Fiscal Year: 2016..including immunohistochemistry, clinical chemistry, molecular diagnostics, flow cytometry, cytogenetics, and a CLI/VCAP, GLP compliant histopathology laboratory...
- MEGAN A FETTIG; Fiscal Year: 2014..neurons located within the periaqueductal gray (PAG) and the rostral and caudal linear nuclei of the raphe (RLi and CLi)...
- Asrar B Malik; Fiscal Year: 2016..abstract_text> ..
- Genetic Analysis of EGFRvIII-independent Glioblastoma MaintenanceTIFFANY ELIZABETH TAYLOR; Fiscal Year: 2013..From this screen, the focus was directed toward two apoptosis-related genes: Aurora kinase A (AURKA) and Clusterin (CLU)...
- Anne Laure Perraud; Fiscal Year: 2014..of the novel Ca2+-mobilizing second messenger ADP-ribose (ADPR), and of its effector molecule, the ADPR-gated TRPM2 ion channel...
- Alzheimer's Abeta, apolipoproteins and blood-brain barrierBerislav V Zlokovic; Fiscal Year: 2013..between apolipoprotein (apo) E and the low density lipoprotein receptor (LDLR) and the interactions between apoJ and LDLR-related protein 2 (LRP2) regulate A[unreadable] clearance from brain and its retention in the CNS...
- Exercise Dose-Response Effects in Prediabetes: Responses and MechanismsWilliam E Kraus; Fiscal Year: 2013..of these three exercise-only interventions by comparing them to a six-month clinical lifestyle intervention (CLI) that contains the components of the DPP but which is of much shorter duration...
- Santiago Partida-Sanchez; Fiscal Year: 2014..i) Exclusive localization of functional Ca2+-permeant melastatin-related transient receptor potential channel (TRPM2) in endolysosomal compartments of DCs...
- JOSEPH B ROGERS; Fiscal Year: 2015..the third highest association with genetic risk for Alzheimer's disease (AD), following only ApoE and ApoJ. Three non-overlapping GWAS efforts have confirmed a highly significant CR1 SNP association with AD risk...
- Paul M Thompson; Fiscal Year: 2016..Carriers of a common AD risk gene (CLU) have deficits in white matter integrity even as young adults and AD pathology may later exploit this vulnerability...
- TIMOTHY CONRAD JENKINS; Fiscal Year: 2016..In summary, the proposed research will provide essential data to move the field of SSTI research forward while facilitating Dr. Jenkins'development into an independently funded investigator. ..
- Simon R Cherry; Fiscal Year: 2015..has led to the development of a new hybrid molecular imaging modality known as Cerenkov luminescence imaging (CLI) that allows the spatial distribution of biomolecules labeled with ?-emitting radionuclides to be imaged in vivo ..
- Steven G Younkin; Fiscal Year: 2016..Variants in two genetic loci that play roles in the complement cascade, CR1 and CLU, show significant genetic associations with AD, and rare coding variants in TREM2 also confer substantial risk for ..
- Richard P Mayeux; Fiscal Year: 2016..to validate and quantify the clinical impact of these newly identified genetic risk factors, namely SNPs in PICALM, CLU, BIN1, MS4A gene clusters, CD33, CD2AP, ABCA7 and EPHA1 using the multiplex families recruited through the National ..
- Susan M Kegeles; Fiscal Year: 2016..Research suggests that HIV+ YBMSM engage in the CC far less than others. A community-level intervention (CLI) to build and mobilize communities of YBMSM to support HIV+ men to engage in the CC, decrease psychosocial barriers ..
- Dihydrodiol dehydrogenase mediates cisplatin resistanceHenry Simpkins; Fiscal Year: 2007..Four genes were found to be upregulated in the cisplatin-resistant ceils: tropomyosin, apolipoprotein J (clusterin), glucose dehydrogenase and dihydro dehydrogenase...
- UCLA Graduate Training Progams in Translational and Cli*ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2010..Educators from the UCLA Center for Educational Development and Research have implemented performance evaluation mechanisms to tssess the quality and outcomes of the program for the purposes of continuous improvement. ..
- M Ilyas Kamboh; Fiscal Year: 2016..have identified significant associations of LOAD with SNPs in nine additional loci, including, ABCA7, MS4A4, EPHA1, CLU, CR1, PICALM, BIN1, CD2AP and CD33 and all, but CR1 and CD2AP, have been replicated in our GWAS sample...
- ALCOHOL, APOLIPOPROTEIN-J BIOCHEMISTRY, AND HDL FUNCTIONPradeep Ghosh; Fiscal Year: 1999..Recently, Apo J, a 70-kDa protein has been identified as an integral component of human plasma HDL and its role in the reverse ..
- STRUCTURE/FUNCTION OF ALZHEIMERS AMYLOID-B AGGREGATESGRANT KRAFFT; Fiscal Year: 2000..to characterize structural aspects of AB interactions with two other plaque components, apolipoprotein E (apoE) and apoJ, which are elevated in AD brain tissue...
- PROSTATIC REGRESSION--DEVELOPMENTAL APPROACHGerald Cunha; Fiscal Year: 1992..All specific aims will be examined through use of both normal and neoplastic prostatic tissue...
- ONTOGENY OF DEPRESSIVE SUBSTRATESPingfu Feng; Fiscal Year: 2001..In past work investigator found that if neonatal rats were treated with clomipramine (CLI) and other antidepressant drugs they developed signs of depression when they became adults...
- Apoj/Clusterin:A Protective Protein In Vascular BiologyNORMAN GRANHOLM; Fiscal Year: 2005..Our Preliminary Results suggest that apolipoprotein (apo) J / clusterin may be an important regulator in determining the vascular response to injury and the development of the ..
- RENAL GROWTH/DURING URETERAL OBSTRUCTIONIhor Sawczuk; Fiscal Year: 1993..In either case, it is a fascinating marker of tissue degeneration and atrophy. Antibodies will be produced in order to determine its cellular localization and other physical characteristics of the TRPM-2 protein product...
- Berislav V Zlokovic; Fiscal Year: 2016..AB is implicated in the neuropathology of AD and related disorders. Apolipoproteins J and E (apoJ, apoE) co-localize with the senile plaques and congophilic angiopathy of AD...
- Breast Cancer Therapy by Differentiation Gene ActivationIrma Russo; Fiscal Year: 2006..the synthesis of inhibin, a secreted protein with tumor suppressor activity, and activation of the apoptotic genes TRPM2, ICE, p53, c-myc, WAF-1 /CIP-1, bcI-XS, and p53...
- COMPLEMENT EXPRESSION IN ALZHEIMER'S DISEASE BRAINSteven Johnson; Fiscal Year: 1993..We found several C component mRNAs up-regulated in AD brain, including SGP-2/CLI, an inhibitor of the C5b-9 membrane attack complex...
- SGP-2 (CLUSTERIN) AND REPRODUCTIONMichael Griswold; Fiscal Year: 2003b>Clusterin is the major protein secreted by cultured Sertoli cells. Clusterin is heavily glycosylated protein consisting of disulfide linked heteromonomers and is expressed by many cells but primarily by those of epithelial origin...
- The Role of ADAM15 in sTie2 shedding in Ischemic AngiogenesisDaniel Corey; Fiscal Year: 2009..To date, the role of elevated sTie2 in CLI and other disease states is not known, and whether ADAM15 is involved in sTie2 shedding in vivo remains unclear...
- INHIBITION AND MECHANISM OF AMYLOID BETA-AGGREGATIONMichael Zagorski; Fiscal Year: 2004..inhibitor bindings sites or surfaces, Aim 3 will conduct NMR binding studies with macromolecules (such as ApoE and ApoJ) and presumed amyloid inhibitors with monomeric Abeta (1-40) and Abeta (1-42)...
- SUPRAMOLECULAR A/BETA--GLIAL INTERACTIONS & CELL RESPONSLinda Van Eldik; Fiscal Year: 1999..on the levels and activity of six relevant glial proteins: a 1-antichymotrypsin (ACT), apolipoprotein E (apoE), apoJ, butyrylcholinesterase (BChE), interleukin-1 (IL-1), and S100 beta ...
- Novel A-beta mutation associated with familial CAAG Rebeck; Fiscal Year: 2001..We will examine whether mutant Abeta fibrillogenesis is altered by binding proteins (apoE, apoJ) and cations (calcium, iron) and test whether Abeta exhibits altered toxicity towards smooth muscle cells in vitro...
- REGULATION OF AN EXTRACELLULAR XENOBIOTIC RESPONSE GENEBruce Aronow; Fiscal Year: 1999..b>ApoJ, an evolutionarily conserved secretory glycoprotein capable of binding diverse hydrophobic molecules, has been ..
- CLUSTERIN--AN ANTI APOPTOTIC MEDIATOR IN PROSTATE CANCERChung Lee; Fiscal Year: 2004..Clusterin has many names, including sulfated glycoprotein-2 (SGP-2), apolipoprotein J (Apo-J), complement lysis inhibitor (CLI), testosterone repressed prostate message-2 (TRPM-2), etc...
- LUPUS NEPHRITIS: ROLE OF ENVIORM. & OCCUPATIONAL EXP.MARY DOOLEY; Fiscal Year: 2000..Using study subjects from the Carolina Lupus Study (CLU) and from the Glomerular Disease Collaborative Network (GDCN), this proposal has two aims: 1...
- ApoJ (Clusterin) in Alzheimer's Disease and AgingCaleb Finch; Fiscal Year: 2006b>Apolipoprotein J (clusterin, SGP-2) expression is increased during Alzheimer disease (AD) and to a lesser extent during normal brain again. New data shows that apoL can activate microglia in vivo and in vitro...
- DOPAMINERGIC AND BASAL GANGLIA PLASTICITY IN AGINGTHOMAS MCNEILL; Fiscal Year: 2002..In addition, we will analyze the expression of several recently discovered genes, including apoJ, SCG-10, BDNF, GDNF, which seem to play key roles in processes determining cell survival and plasticity...
- XIP8, AN X RAY INDUCIBLE KU70 BINDING PROTEINDavid Boothman; Fiscal Year: 2001..e., testosterone repressed message-2 (TRPM-2)/apolipoprotein J (ApoJ)], a protein that strongly associate with the Ku780 DSB repair protein...
- Functional Outcome of Critical Limb IschemiaGregory Landry; Fiscal Year: 2009..The proposed research focuses on functional outcomes of patients undergoing treatment for critical limb ischemia (CLI)...
- Enhanced VEGF Gene Transfer for Critical Limb IschemiaEdward Nolan; Fiscal Year: 2003Angiogenic gene transfer is currently being investigated in clinical trials to treat critical limb ischemia (CLI)...
- SIALIC ACID DEFICIENT APOJ (SDJ)--ALCOHOL INTAKE MARKERRaj Lakshman; Fiscal Year: 2000..The applicants have demonstrated the validity and feasibility of the use of sialic acid deficiency of plasma Apolipoprotein J(SDJ) as a biological marker for alcohol consumption in rats...
- Endothelial Cell Regulation of Smooth Muscle PhenotypeRichard Powell; Fiscal Year: 2007..abstract_text> ..
- 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSISMichael Weiner; Fiscal Year: 2002..abstract_text> ..
- Varian 4 Tesla MRI/MRS for Neuro-degenerative DiseasesMichael Weiner; Fiscal Year: 2002..These expected results emphasize the practical outcome and significance of this research. ..
- GENETIC ENGINEERING OF A FAILURE RESISTANT VEIN GRAFTMichael Conte; Fiscal Year: 2003..The long term objective is to develop a safe, efficient, and effective protocol for intraoperative gene therapy that will engineer vein bypass grafts that are resistant to occlusion. ..
- SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETINBarbara Miller; Fiscal Year: 2007..abstract_text> ..
- CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLSReinhold Penner; Fiscal Year: 2005..abstract_text> ..
- Molecular and functional properties of the TRPM2 catioin channelReinhold Penner; Fiscal Year: 2010..We identified TRPM2, a member of the TRP family, as a calcium-permeable cation channel gated by the novel second messenger ADP-ribose (..
- NSAID Inhibition of Alzheimer Pathology: Role of DHAGregory M Cole; Fiscal Year: 2010..Understanding dietary fatty acid /Abeta-related PAK complex deficits and downstream synaptic defects will reveal a poorly studied overlap between cognitive deficits in mental retardation syndromes and AD with therapeutic implications. ..
- Molecular mechanisms of vertebrate Mg2+ homeostasisAndrew Scharenberg; Fiscal Year: 2009..Together, the proposed studies will generate a foundation of knowledge on the molecular mechanisms of Mg uptake and their integration with mechanisms which regulate cell growth and proliferation. ..
- Characterization of a novel metal ion permeable channelMeredith Hermosura; Fiscal Year: 2006..These mutations will be then engineered in the expression system to assess resulting alterations in channel function. ..
- Targeted gene repair of primary immune deficienciesAndrew Scharenberg; Fiscal Year: 2006..Overall, the work proposed here will build a foundation of materials and experience for the development of LHE's as general tools for targeted gene therapy of human primary immune deficiencies. ..
- TRPM2 HTS Screening Assay Development(RMI)Andrew Scharenberg; Fiscal Year: 2005The TRPM2 Ca2+-permeable cation channel opens in response to binding of ADP-ribose to a well defined C-terminal gating domain...
- ANALYSIS OF B-CELL RECEPTOR CALCIUM SIGNALINGAndrew Scharenberg; Fiscal Year: 2004..abstract_text> ..
- CYTOLYSIS INHIBITOR PROTEINS (CLI) AND DNA SEQUENCES CODING FOR SAID PROTEINSPatent Number: WO9105043-A1; Date:1991-04-18