CLU

Summary

Gene Symbol: CLU
Description: clusterin
Alias: AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin, aging-associated protein 4, apolipoprotein J, complement cytolysis inhibitor, complement lysis inhibitor, complement-associated protein SP-40,40, ku70-binding protein 1, sulfated glycoprotein 2, testosterone-repressed prostate message 2
Species: human

Top Publications

  1. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
  2. ncbi Clusterin/apolipoprotein J in human aging and cancer
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Int J Biochem Cell Biol 34:1430-48. 2002
  3. ncbi Clusterin
    Steve E Jones
    Retinitis Pigmentosa Research Unit, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, The Rayne Institute, St Thomas Hospital, Londoon SE1 7EH, UK
    Int J Biochem Cell Biol 34:427-31. 2002
  4. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
  5. pmc Genetics of clusterin isoform expression and Alzheimer's disease risk
    I Fang Ling
    Department of Physiology and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e33923. 2012
  6. ncbi Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability
    Kwan Bok Lee
    School of Bioscience and Biotechnology, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 366:905-9. 2008
  7. doi Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease
    Yao Yao Xing
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 29:515-9. 2012
  8. pmc Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    Madhav Thambisetty
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 67:739-48. 2010
  9. pmc Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults
    MEREDITH N BRASKIE
    Laboratory of Neuro Imaging, Department of Neurology, University of California, School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 31:6764-70. 2011
  10. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012

Research Grants

  1. MICHAEL PATRICK MURPHY; Fiscal Year: 2016
  2. Kenneth Rosenfield; Fiscal Year: 2016
  3. Flora Sandra Siami; Fiscal Year: 2016
  4. Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative Cells
    Erik J Woods; Fiscal Year: 2010
  5. Laura J Suggs; Fiscal Year: 2015
  6. Raj Kishore; Fiscal Year: 2015
  7. RAYMOND QUEZON MIGRINO; Fiscal Year: 2015
  8. Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and Cli
    JOAN MARIE CRANMER; Fiscal Year: 2010
  9. Robyn A Honea; Fiscal Year: 2015
  10. Sanford A Stass; Fiscal Year: 2016

Patents

  1. CYTOLYSIS INHIBITOR PROTEINS (CLI) AND DNA SEQUENCES CODING FOR SAID PROTEINS

Detail Information

Publications263 found, 100 shown here

  1. pmc Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    Denise Harold
    Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK
    Nat Genet 41:1088-93. 2009
    ..significant association with SNPs at two loci not previously associated with the disease: at the CLU (also known as APOJ) gene (rs11136000, P = 1.4 x 10(-9)) and 5' to the PICALM gene (rs3851179, P = 1.9 x 10(-8))...
  2. ncbi Clusterin/apolipoprotein J in human aging and cancer
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Int J Biochem Cell Biol 34:1430-48. 2002
    Clusterin/Apolipoprotein J (ApoJ) is a heterodimeric highly conserved secreted glycoprotein being expressed in a wide variety of tissues and found in all human fluids...
  3. ncbi Clusterin
    Steve E Jones
    Retinitis Pigmentosa Research Unit, Division of Pharmacology and Therapeutics, GKT School of Biomedical Sciences, The Rayne Institute, St Thomas Hospital, Londoon SE1 7EH, UK
    Int J Biochem Cell Biol 34:427-31. 2002
    b>Clusterin is an enigmatic glycoprotein with a nearly ubiquitous tissue distribution and an apparent involvement in biological processes ranging from mammary gland involution to neurodegeneration in Alzheimer's disease...
  4. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
  5. pmc Genetics of clusterin isoform expression and Alzheimer's disease risk
    I Fang Ling
    Department of Physiology and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e33923. 2012
    ..and secreted proteins, respectively, we compared their expression; for both CLU1 and CLU2 transfected cells, clusterin is present in the secretory pathway, accumulates in the extracellular media, and is similar in size to clusterin ..
  6. ncbi Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability
    Kwan Bok Lee
    School of Bioscience and Biotechnology, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 366:905-9. 2008
    b>Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis...
  7. doi Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease
    Yao Yao Xing
    Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China
    J Alzheimers Dis 29:515-9. 2012
    Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown...
  8. pmc Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    Madhav Thambisetty
    King s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 67:739-48. 2010
    ..Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD)...
  9. pmc Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults
    MEREDITH N BRASKIE
    Laboratory of Neuro Imaging, Department of Neurology, University of California, School of Medicine, Los Angeles, California 90095, USA
    J Neurosci 31:6764-70. 2011
    ..A newly confirmed genetic risk allele C of the clusterin (CLU) gene variant rs11136000 is carried by ∼88% of Caucasians. The C allele confers a 1...
  10. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    We have followed-up on the recent genome-wide association (GWA) of the clusterin gene (CLU) with increased risk for Alzheimer disease (AD), by performing an unbiased resequencing of all CLU coding exons and regulatory regions in an ..
  11. ncbi Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study
    P Giannakopoulos
    Department of Psychiatry, University of Geneva School of Medicine, Chene Bourg, Switzerland
    Acta Neuropathol 95:387-94. 1998
    b>Clusterin is a secreted glycoprotein that is expressed in response to tissue injury both in peripheral organs and in the brain...
  12. doi Potential protective role of apoprotein J (clusterin) in atherogenesis: binding to enzymatically modified low-density lipoprotein reduces fatty acid-mediated cytotoxicity
    Margarethe Schwarz
    Institute of Medical Microbiology and Hygiene, Hochhaus am Augustusplatz, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
    Thromb Haemost 100:110-8. 2008
    ..Apoprotein J (ApoJ) alias clusterin is a multifunctional glycoprotein with cytoprotective and anti-inflammatory properties...
  13. doi Clusterin (CLU) and prostate cancer
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno 39 43100 Parma, Italy
    Adv Cancer Res 105:1-19. 2009
    The role of clusterin (CLU) in prostate tumorigenesis is probably the most highly controversial, with evidence that CLU expression is increased or decreased in different cancer models...
  14. ncbi Apolipoprotein J and leptin levels in patients with coronary heart disease
    Maria V Poulakou
    Department of Experimental Surgery and Surgical Research N S Christeas, Medical School, National and Kapodistrian University of Athens, Athens, Greece
    In Vivo 22:537-42. 2008
    Preliminary data suggest that apolipoprotein J (ApoJ) may play a role in the development and progression of atherosclerosis. Leptin, an adipose tissue hormone, exerts important cardiovascular effects...
  15. doi Serum clusterin levels are not increased in presymptomatic Alzheimer's disease
    Linda Ijsselstijn
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Proteome Res 10:2006-10. 2011
    Increased plasma levels of clusterin have recently been found to be associated with severity and progression in Alzheimer's disease (AD)...
  16. doi The clusterin paradigm in prostate and breast carcinogenesis
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Parma, Italy
    Endocr Relat Cancer 17:R1-17. 2010
    The biological functions of clusterin (CLU, also known as ApoJ, SGP2, TRPM-2, CLI) have been puzzling the researchers since its first discovery in the early 80's...
  17. pmc Identification of clusterin domain involved in NF-kappaB pathway regulation
    Abdellatif Essabbani
    INSERM, U567, Institut Cochin, 75014 Paris, France
    J Biol Chem 285:4273-7. 2010
    b>Clusterin (CLU) is a ubiquitous protein that has been implicated in tumorigenesis, apoptosis, inflammation, and cell proliferation. We and others have previously shown that CLU is an inhibitor of the NF-kappaB pathway...
  18. ncbi Transforming growth factor beta (TGF beta)-induced nuclear localization of apolipoprotein J/clusterin in epithelial cells
    K B Reddy
    Department of Cell Biology, Cleveland Clinic Research Institute, Ohio 44195 5245, USA
    Biochemistry 35:6157-63. 1996
    b>Apolipoprotein J (apoJ)/clusterin was first identified as an 80 kDa secretory glycoprotein present in most body fluids. It has been implicated in a variety of physiological processes including cellular differentiation and apoptosis...
  19. ncbi Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional inter
    Karen L Grogg
    Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Surg Pathol 28:988-98. 2004
    ..Based on observations that clusterin is expressed in benign follicular dendritic cells, clusterin expression in 32 dendritic cell tumors was ..
  20. ncbi Protection of androgen-dependent human prostate cancer cells from oxidative stress-induced DNA damage by overexpression of clusterin and its modulation by androgen
    Hideaki Miyake
    Department of Urology, Hyogo Medical Center for Adults, Akashi, Japan hideakimiyake
    Prostate 61:318-23. 2004
    ..the effect of oxidative stress on cell injury using androgen-dependent human prostate cancer LNCaP cells overexpressing clusterin, which has been shown to play crucial roles in the acquisition of resistance to several apoptotic stimuli.
  21. pmc CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor
    Konstantin S Leskov
    Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Biol Chem 286:40083-90. 2011
    Expression of the clusterin (CLU) gene results in the synthesis of a conventional secretory isoform set (pre- and mature secretory clusterin proteins, psCLU/sCLU), as well as another set of intracellular isoforms, appearing in the ..
  22. pmc Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid
    D E Jenne
    Institut de Biochimie, Universite de Lausanne, Switzerland
    Proc Natl Acad Sci U S A 86:7123-7. 1989
    ..The protein, which we have designated complement cytolysis inhibitor (CLI), has a molecular mass of 70 kDa and consists of two nonidentical, disulfide-linked subunits of ..
  23. ncbi Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells
    A E Caccamo
    Cell Death Differ 12:101-4. 2005
  24. ncbi Clusterin/Apolipoprotein J up-regulation after zinc exposure, replicative senescence or differentiation of human haematopoietic cells
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Ave, Athens, 11635, Greece
    Biogerontology 7:375-82. 2006
    Clusterin/Apolipoprotein J (CLU) is a cellular senescence biomarker implicated in several physiological processes. In this work we have investigated CLU expression and function in human haematopoietic cells...
  25. ncbi Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis
    Valerie Devauchelle
    Institut Cochin, Departement d Immunologie, 27 rue du Faubourg Saint Jacques, 75674 Paris Cedex 14, France
    J Immunol 177:6471-9. 2006
    ..Among the set of genes identified as a molecular signature of RA, clusterin (clu) was one of the most differentially expressed...
  26. ncbi The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
    Justin J Yerbury
    School of Biological Sciences, University of Wollongong, Wollongong, Australia
    FASEB J 21:2312-22. 2007
    b>Clusterin is an extracellular chaperone present in all disease-associated extracellular amyloid deposits, but its roles in amyloid formation and protein deposition in vivo are poorly understood...
  27. pmc Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems
    L Kirszbaum
    Department of Veterinary Preclinical Sciences, University of Melbourne, Victoria, Australia
    EMBO J 8:711-8. 1989
    ..The precise role of SP-40,40 is not known in either blood or semen but the present findings document an intriguing link between the immune and the reproductive systems...
  28. ncbi Apolipoprotein J expression in human ocular surface epithelium
    K Nishida
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Invest Ophthalmol Vis Sci 37:2285-92. 1996
    b>Apolipoprotein J (apoJ) expression has been detected in various mouse mucosal epithelial cells, as well as in the human ciliary body, retina, vitreous humor, and aqueous humor...
  29. ncbi Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke
    Stefano Carnevali
    Department of Oncology, Haematology, and Pulmonology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Am J Respir Crit Care Med 174:393-9. 2006
    ..b>Clusterin is a widely distributed protein with many functions, including cellular protection in response to oxidative ..
  30. pmc Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation
    Hakryul Jo
    Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 28:4285-99. 2008
    ..use of biochemical purification, we reveal that cancer cell-secreted insulin-like growth factor 1 (IGF-1) and clusterin, an extracellular stress protein, constitute this regulatory system...
  31. ncbi Clusterin: the intriguing guises of a widely expressed glycoprotein
    D E Jenne
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Trends Biochem Sci 17:154-9. 1992
    The glycoprotein clusterin has recently entered the scientific arena in diverse guises...
  32. ncbi Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
    Saverio Bettuzzi
    Dipartimento di Medicina Sperimentale, Universita di Parma, Via Volturno, 39 43100 Parma, Italy
    Oncogene 21:4328-34. 2002
    b>Clusterin is a highly conserved, widely distributed glycoprotein whose biological significance is still debated...
  33. ncbi Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Ageing, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Avenue, Athens 11635, Greece
    Exp Gerontol 37:1175-87. 2002
    Clusterin/apolipoprotein J (hereafter ApoJ) is a conserved secreted glycoprotein expressed by a wide array of tissues and being implicated in several physiological processes...
  34. ncbi Synthesis and functional analyses of nuclear clusterin, a cell death protein
    Konstantin S Leskov
    Department of Radiation Oncology, Laboratory of Molecular Stress Responses, Ireland Comprehensive Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4942, USA
    J Biol Chem 278:11590-600. 2003
    Nuclear clusterin (nCLU) is an ionizing radiation (IR)-inducible protein that binds Ku70, and triggers apoptosis when overexpressed in MCF-7 cells. We demonstrate that endogenous nCLU synthesis is a product of alternative splicing...
  35. ncbi Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity
    Giorgia Santilli
    Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London WC1N, United Kingdom
    J Biol Chem 278:38214-9. 2003
    b>Apolipoprotein J/clusterin is an enigmatic protein highly regulated in inflammation, apoptosis, and cancer. Despite extensive studies, its biological function has remained obscure...
  36. pmc Alterations in expression, proteolysis and intracellular localizations of clusterin in esophageal squamous cell carcinoma
    Hong Zhi He
    National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    World J Gastroenterol 10:1387-91. 2004
    To investigate biogenesis and intracellular localizations of clusterin to elucidate the potential molecular mechanisms implicated in tumorigenesis of esophageal mucosa.
  37. ncbi Differential effects of clusterin/apolipoprotein J on cellular growth and survival
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas Constantinou Ave, Athens 11635, Greece
    Free Radic Biol Med 38:436-49. 2005
    The secreted clusterin/apolipoprotein J (CLU) protein form is a ubiquitously expressed heterodimeric glycoprotein which is differentially regulated in many severe physiological disturbance states including cell death, ageing, cancer ..
  38. ncbi Clusterin inhibits apoptosis by interacting with activated Bax
    Honglai Zhang
    Laboratory of Molecular Signaling and Apoptosis, Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Nat Cell Biol 7:909-15. 2005
    b>Clusterin is an enigmatic glycoprotein that is overexpressed in several human cancers such as prostate and breast cancers, and squamous cell carcinoma...
  39. ncbi Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells
    Alessandro E Caccamo
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Universita di Parma, Via Volturno Parma, Italy
    J Cell Physiol 207:208-19. 2006
    b>Clusterin (CLU), whose role is still debated, is differentially regulated in several patho-physiological processes and invariably induced during apoptosis...
  40. ncbi Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms
    A M Nilselid
    Institute of Clinical Neuroscience, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital, SE 431 80 Molndal, Sweden
    Neurochem Int 48:718-28. 2006
    b>Clusterin is suggested to be involved in the pathogenesis of Alzheimer's disease...
  41. doi Clusterin silencing in human lung adenocarcinoma cells induces a mesenchymal-to-epithelial transition through modulating the ERK/Slug pathway
    Teh Ying Chou
    Institute of Clinical Medicine, National Yang Ming University, Taiwan
    Cell Signal 21:704-11. 2009
    The ubiquitously expressed glycoprotein Clusterin (CLU) is implicated in diverse cellular processes, yet its genuine molecular function remains undefined...
  42. ncbi Transcriptional and posttranslational regulation of clusterin by the two main cellular proteolytic pathways
    Eirini Balantinou
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vas Constantinou Avenue, Athens, Greece
    Free Radic Biol Med 46:1267-74. 2009
    Clusterin/apolipoprotein J (CLU) is a secreted glycoprotein associated with many severe physiological disturbances that represent states of increased oxidative stress, such as aging, cancer, atherosclerosis, diabetes, and renal and ..
  43. doi Clusterin: a forgotten player in Alzheimer's disease
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Brain Res Rev 61:89-104. 2009
    Clusterin, also known as apolipoprotein J, is a versatile chaperone molecule which contains several amphipathic and coiled-coil alpha-helices, typical characteristics of small heat shock proteins...
  44. doi Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    ..Two loci gave replicated evidence of association: one within CLU (also called APOJ), encoding clusterin or apolipoprotein J, on chromosome 8 (rs11136000, OR = 0.86, 95% CI 0.81-0.90, P = 7...
  45. doi Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinoma
    Li Ru He
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Cancer Sci 100:2354-60. 2009
    b>Clusterin (CLU) is frequently overexpressed and correlates closely with chemotherapy and radiotherapy resistance and poor prognosis in many human cancers...
  46. doi Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
    Adv Cancer Res 104:9-23. 2009
    b>Clusterin (CLU) has kept many researchers engaged for a long time since its first discovery and characterization in the attempt to unravel its biological role in mammals...
  47. doi The role of clusterin (CLU) in malignant transformation and drug resistance in breast carcinomas
    Maximino Redondo
    Department of Biochemistry, Hospital Costa del Sol, CIBER Epidemiología y Salud Pública, Universidad de Malaga, Marbella, Spain
    Adv Cancer Res 105:21-43. 2009
    ..Secretory clusterin (sCLU) is an extracellular chaperone that has been functionally implicated in DNA repair, cell-cycle regulation, ..
  48. doi Regulation of clusterin expression in human cancer via DNA methylation
    Alfonso Serrano
    Department of Immunology, Hospital Clinico Universitario, Campus Universitario Teatinos, Malaga, Spain
    Tumour Biol 30:286-91. 2009
    b>Clusterin has attracted much recent attention because of its association with tumorigenesis and the progression of human carcinomas...
  49. pmc Replication of CLU, CR1, and PICALM associations with alzheimer disease
    Minerva M Carrasquillo
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Birdsall Building, Jacksonville, FL 32224, USA
    Arch Neurol 67:961-4. 2010
    To test for replication of the association between variants in the CLU, CR1, and PICALM genes with Alzheimer disease.
  50. doi Association of the clusterin gene polymorphisms with type 2 diabetes mellitus
    Makoto Daimon
    Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata 990 9585, Japan
    Metabolism 60:815-22. 2011
    The association of the clusterin (CLU) gene polymorphism (single nucleotide polymorphisms [SNPs] 1-4: rs1532278, rs1532277, rs2279590, and rs2279591, respectively) with type 2 diabetes mellitus was examined using a population of the ..
  51. doi The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels
    Brit Maren M Schjeide
    Department Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Arch Gen Psychiatry 68:207-13. 2011
    Two recent and simultaneously published genome-wide association studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel ..
  52. doi Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
    Britta Schürmann
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    J Alzheimers Dis 25:421-4. 2011
    A variant within the clusterin gene has been recently associated with increased risk for Alzheimer's disease (AD) in genome wide association studies...
  53. doi Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancer
    Masaki Shiota
    The Vancouver Prostate Centre and Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada
    Mol Cancer Res 9:1755-66. 2011
    b>Clusterin is a stress-activated, cytoprotective chaperone that confers broad-spectrum treatment resistance in cancer...
  54. doi GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer
    N Li
    Department of Urologic Sciences, The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Oncogene 32:1933-42. 2013
    Expression of clusterin (CLU) closely correlates with the regulation of apoptosis in cancer...
  55. doi Tumor-derived secretory clusterin induces epithelial-mesenchymal transition and facilitates hepatocellular carcinoma metastasis
    Cun Wang
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China
    Int J Biochem Cell Biol 44:2308-20. 2012
    ..Twenty tumor-derived proteins were identified through human specific peptides. Secretory clusterin (sCLU), which was significantly upregulated during cancer progression and metastasis, was chosen for further ..
  56. doi Unglycosylated clusterin variant accumulates in the endoplasmic reticulum and induces cytotoxicity
    Sang Wook Kang
    Graduate School, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Int J Biochem Cell Biol 45:221-31. 2013
    b>Clusterin is a stress-responsive and highly glycosylated secretory protein that plays cytoprotective role in most body fluids...
  57. doi Genetic variation in clusterin gene and Alzheimer's disease risk in Han Chinese
    Jin Tai Yu
    College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China
    Neurobiol Aging 34:1921.e17-23. 2013
    Clusterin gene (CLU), also known as apolipoprotein J (ApoJ), is a strong candidate gene for late-onset Alzheimer's disease (LOAD) according to the Alzgene database...
  58. pmc The role of clusterin in amyloid-β-associated neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, La Jolla
    JAMA Neurol 71:180-7. 2014
    Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well understood.
  59. ncbi Identification of the disulfide bonds in human plasma protein SP-40,40 (apolipoprotein-J)
    N H Choi-Miura
    Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo
    J Biochem 112:557-61. 1992
    ..The unique structure could be related to the functions of SP-40,40...
  60. ncbi Apolipoprotein J: structure and tissue distribution
    H V de Silva
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio 45267 0575
    Biochemistry 29:5380-9. 1990
    ..ApoJ appears to be the human analogue of a rat protein present in high concentrations in the testis, sulfated glycoprotein 2. ApoJ mRNA (1.9 kb) is expressed in all but one tissue examined...
  61. ncbi Local synthesis of apolipoprotein J in the eye
    D J Reeder
    Department of Ophthalmology, University of Cincinnati College of Medicine, OH, USA
    Exp Eye Res 60:495-504. 1995
    b>Apolipoprotein J (apoJ), a secretory glycoprotein known to transport lipids and to regulate terminal complement function, is present in the human eye in both aqueous and vitreous, as well as in the retina...
  62. ncbi Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration
    P Wong
    Department of Biochemistry, University of Ottawa, Canada
    Eur J Biochem 221:917-25. 1994
    The TRPM-2/clusterin gene and its cognate protein has been characterized in a number of species...
  63. ncbi Apolipoprotein J is associated with paraoxonase in human plasma
    G J Kelso
    Department of Pharmacology and Cell Biophysics, College of Medicine, University of Cincinnati, Ohio 45267
    Biochemistry 33:832-9. 1994
    b>Apolipoprotein J (apoJ)-containing high-density lipoproteins (HDL), isolated from human plasma by immunoaffinity chromatography, are associated with apoAI and a protein of approximately 44 kDa...
  64. ncbi Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene
    T M Fink
    Deutsches Krebsforschungszentrum, Schwerpunkt Angewandte Tumorvirologie 06, Heidelberg, Germany
    Genomics 16:526-8. 1993
    b>Clusterin (gene symbol: CLI) is a post-translationally nicked, two-chain plasma and tissue glycoprotein of 80 kDa...
  65. pmc The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
    J Ghiso
    Department of Pathology, New York University Medical Center, NY 10016
    Biochem J 293:27-30. 1993
    ..The protein was unmistakably identified as SP-40,40 or ApoJ, a cytolytic inhibitor and lipid carrier, by means of amino acid sequence and immunoreactivity with specific ..
  66. ncbi Clusterin (Apo J) protects against in vitro amyloid-beta (1-40) neurotoxicity
    L N Boggs
    Lilly Research Laboratories, CNS Research Division, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 67:1324-7. 1996
    b>Clusterin is a secreted glycoprotein that is markedly induced in many disease states and after tissue injury...
  67. pmc Identification and characterization of glycosylation sites in human serum clusterin
    J T Kapron
    W Alton Jones Cell Science Center, Lake Placid, New York 12946, USA
    Protein Sci 6:2120-33. 1997
    b>Clusterin is a ubiquitous, heterodimeric glycoprotein with multiple possible functions that are likely influenced by glycosylation...
  68. ncbi Clusterin has chaperone-like activity similar to that of small heat shock proteins
    D T Humphreys
    Department of Biological Sciences, The University of Wollongong, Northfields Avenue, Wollongong, New South Wales 2522, Australia
    J Biol Chem 274:6875-81. 1999
    b>Clusterin is a highly conserved protein which is expressed at increased levels by many cell types in response to a broad variety of stress conditions. A genuine physiological function for clusterin has not yet been established...
  69. pmc Isolation of Ku70-binding proteins (KUBs)
    C R Yang
    Department of Radiation Oncology and Department of Pharmacology and the Ireland Cancer Center, Laboratory of Molecular Stress Responses, Case Western Reserve University, BRB 326 East, 10900 Euclid Avenue, Cleveland, OH 44106 4942, USA
    Nucleic Acids Res 27:2165-74. 1999
    ..Sequence analyses revealed KUB1 to be apolipoprotein J (apoJ), also known as X-ray-inducible transcript 8 (XIP8), testosterone-repressed prostate message-2 (TRPM-2) ..
  70. ncbi Clusterin is a secreted mammalian chaperone
    M R Wilson
    Dept of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW Australia 2522
    Trends Biochem Sci 25:95-8. 2000
  71. ncbi Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state
    S Poon
    Department of Biological Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia
    Biochemistry 39:15953-60. 2000
    We recently reported that the ubiquitous, secreted protein clusterin has chaperone activity in vitro [Humphreys et al. (1999) J. Biol. Chem. 274, 6875-6881]...
  72. ncbi Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
    Laura V July
    The Prostate Centre, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Prostate 50:179-88. 2002
    ..Testosterone-repressed prostate message-2 (TRPM-2) encodes the anti-apoptotic protein clusterin, which is upregulated in response to cellular compromise as observed in normal and malignant tissues undergoing ..
  73. pmc Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide
    Patrick Dumont
    Unit of Cellular Biochemistry and Biology, Department of Biology, The University of Namur FUNDP, Belgium
    Cell Stress Chaperones 7:23-35. 2002
    ..deletion, and an increase in the steady-state level of several senescence-associated genes such as apolipoprotein J (apo J). Apo J has been described as a survival gene against cytotoxic stress...
  74. ncbi Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies
    Kensuke Sasaki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neuropathol 104:225-30. 2002
    Clusterin/apolipoprotein J protein expression in cases with "alpha-synucleinopathies", such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), was investigated using an immunohistochemical ..
  75. ncbi Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent
    Tingan Chen
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 64:7412-9. 2004
    b>Clusterin is a widely expressed glycoprotein that has been paradoxically observed to have both pro- and antiapoptotic functions...
  76. ncbi Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor
    Tracy Criswell
    Department of Radiation Oncology and Program in Molecular and Cellular Basis of Disease, Laboratory of Molecular Stress Responses, Case Comprehensive Cancer Center, Cleveland, Ohio 44106 7285, USA
    J Biol Chem 280:14212-21. 2005
    Secretory clusterin protein (sCLU) is a general genotoxic stress-induced, pro-survival gene product implicated in aging, obesity, heart disease, and cancer...
  77. ncbi Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
    Yoshikazu Miwa
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Biochem Biophys Res Commun 331:1587-93. 2005
    b>Clusterin has been implicated in lipid metabolism and atherogenesis, however, the influence of genetic variation has not been examined in Japanese...
  78. pmc Oncogenic role of clusterin overexpression in multistage colorectal tumorigenesis and progression
    Dan Xie
    Department of Clinical Oncology, The University of Hong Kong, Room 109, School of Chinese Medicine Building, 10 Sassoon Road, Hong Kong, China
    World J Gastroenterol 11:3285-9. 2005
    To investigate the expression pattern of clusterin in colorectal adenoma-carcinoma-metastasis series, and to explore the potential role of clusterin in multistage colorectal tumorigenesis and progression.
  79. ncbi Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer
    B Shannan
    Department of Dermatology, The Saarland University Hospital, Homburg 66421, Germany
    Cell Death Differ 13:12-9. 2006
    b>Clusterin (CLU) has been implicated in various cell functions involved in carcinogenesis and tumour progression. There are two known CLU protein isoforms generated in human cells...
  80. ncbi Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells
    Paola Strocchi
    Department of Pharmacology, University of Bologna, Bologna 40126, Italy
    Neurobiol Aging 27:1588-94. 2006
    Clusterin/apolipoprotein J is a multifunctional protein up-regulated during various pathophysiological states...
  81. ncbi Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control
    B Shannan
    Department of Dermatology, The Saarland University Hospital, Building 18, Homburg Saar 66421, Germany
    J Mol Histol 37:183-8. 2006
    The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival...
  82. ncbi Differential regulation of clusterin and its isoforms by androgens in prostate cells
    Dawn R Cochrane
    Department of Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 282:2278-87. 2007
    b>Clusterin mRNA levels were shown to increase dramatically in rat ventral prostate following castration, and clusterin was therefore originally thought to be repressed by androgens...
  83. ncbi Clusterin expression in normal mucosa and colorectal cancer
    Claus Lindbjerg Andersen
    Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, DK8200 Aarhus N, Denmark
    Mol Cell Proteomics 6:1039-48. 2007
    The gene Clusterin is a target for cancer therapy in clinical trials. The indication for intervention is up-regulated Clusterin expression...
  84. ncbi Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol
    Philippe Nizard
    UMR6026 CNRS Université de Rennes1, Intracellular Protein Homeostasis, IFR 140, Campus de Beaulieu, Bat 13, 35042 Rennes Cedex, France
    Traffic 8:554-65. 2007
    b>Clusterin is a usually secreted glycoprotein with chaperone properties...
  85. ncbi Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis
    Roberta M Moretti
    Institute of Endocrinology, University of Milan, Milan, Italy
    Cancer Res 67:10325-33. 2007
    Besides a fully processed, secreted form of clusterin (sCLU), an alternative proapoptotic form of the protein targeting the nucleus (nCLU) was recently described...
  86. pmc Increased clusterin expression in Fuchs' endothelial dystrophy
    Ula V Jurkunas
    Schepens Eye Research Institute, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 49:2946-55. 2008
    To investigate the differential expression of the glycoprotein clusterin/apoJ (CLU) in normal and Fuchs' endothelial dystrophy (FED) corneal endothelium and to compare the expression of various forms of CLU in normal and FED tissue.
  87. doi Clusterin is epigenetically regulated in prostate cancer
    Hanna E Rauhala
    Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland
    Int J Cancer 123:1601-9. 2008
    ..Further studies revealed that clusterin is methylated in the TRAMP-C2 cell line, as well as in the human prostate cancer cell line LNCaP...
  88. pmc Clusterin interacts with Paclitaxel and confer Paclitaxel resistance in ovarian cancer
    Dong Choon Park
    Department of Obstetrics and Gynecology, Saint Vincent s Hospital, The Catholic University of Korea, Suwon, Republic of Korea
    Neoplasia 10:964-72. 2008
    ..from five long-term (>8 years) and five short-term (<2 years) ovarian cancer survivors and identified clusterin as one of the genes that were significantly up-regulated in short-term survivors...
  89. pmc Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex
    Ioannis P Trougakos
    Laboratory of Molecular and Cellular Aging, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Clin Cancer Res 15:48-59. 2009
    Secretory clusterin (sCLU)/apolipoprotein J is an extracellular chaperone that has been functionally implicated in DNA repair, cell cycle regulation, apoptotic cell death, and tumorigenesis...
  90. doi Clusterin is a short half-life, poly-ubiquitinated protein, which controls the fate of prostate cancer cells
    Federica Rizzi
    Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Clinica e Biochimica dell Esercizio Fisico, Parma, Italy
    J Cell Physiol 219:314-23. 2009
    The Clusterin (CLU) gene produces different forms of protein products, which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis...
  91. doi Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells
    Fu Tien Liao
    Institute of Medical and Molecular Toxicology, Chung Shan Medical University, Taichung, Taiwan, Republic of China
    J Gen Virol 90:1124-34. 2009
    ..HCC) cell line Huh7, which stably expresses HDAgs, was differentially screened and the results showed that clusterin gene expression was enhanced. The mechanisms for HDAg-mediated clusterin gene upregulation were investigated...
  92. doi Roles of clusterin in progression, chemoresistance and metastasis of human ovarian cancer
    Li Wei
    Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, People s Republic of China
    Int J Cancer 125:791-806. 2009
    b>Clusterin (CLU) is a multivalent glycoprotein with ubiquitous tissue distribution...
  93. doi A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome
    Anne lie Ståhl
    Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden
    Mol Immunol 46:2236-43. 2009
    A novel heterozygous mutation in the clusterin gene, nucleotide position A1298C (glutamine>proline Q433P), was detected in exon 7 of a child with recurrent hemolytic uremic syndrome (HUS)...
  94. doi Clusterin as a diagnostic and prognostic marker for transitional cell carcinoma of the bladder
    Sahar M Hazzaa
    Clinical Pathology Department, Tanta University, Tanta, Egypt
    Pathol Oncol Res 16:101-9. 2010
    We investigated the feasibility of profiling and measuring the concentration of clusterin in urine and serum for individuals with transitional cell carcinoma (TCC) of the bladder and comparing it with nontumor controls...
  95. doi Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding
    Amy Wyatt
    School of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia
    Adv Cancer Res 104:89-114. 2009
    The function(s) of clusterin may depend upon its topological location. A variety of intracellular "isoforms" of clusterin have been reported but further work is required to better define their identity...
  96. doi CLU and colon cancer. The dual face of CLU: from normal to malignant phenotype
    P Mazzarelli
    Department of Biopathology, Institute of Anatomic Pathology, University of Rome Tor Vergata, 00133 Rome, Italy
    Adv Cancer Res 105:45-61. 2009
    ..b>Clusterin (CLU) is a pleiotropic protein with a broad range of functions...
  97. doi Clusterin (CLU) and lung cancer
    F Panico
    Department of Oncology, Hematology and Respiratory Diseases, Section of Respiratory Diseases, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Adv Cancer Res 105:63-76. 2009
    ..Several in vitro studies have examined the role of Clusterin (CLU) in carcinogenesis, lung cancer progression, and response to chemo- and radiotherapy...
  98. pmc Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
    Amina Zoubeidi
    The Vancouver Prostate Centre and Department of Urological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Mol Cancer Res 8:119-30. 2010
    Secretory clusterin (sCLU) is a stress-activated, cytoprotective chaperone that confers broad-spectrum cancer treatment resistance, and its targeted inhibitor (OGX-011) is currently in phase II trials for prostate, lung, and breast ..
  99. pmc Genetic variability in CLU and its association with Alzheimer's disease
    Rita J Guerreiro
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 5:e9510. 2010
    ..large genome wide association studies in Alzheimer disease (AD) have identified variants in three different genes (CLU, PICALM and CR1) as being associated with the risk of developing AD...
  100. ncbi Overexpression of clusterin correlates with tumor progression, metastasis in gastric cancer: a study on tissue microarrays
    J Bi
    Laboratory of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Neoplasma 57:191-7. 2010
    b>Clusterin (CLU) is expressed in a wide variety of human tissues and fluids. Overexpression of cytoplasmic clusterin (sCLU) has been implicated in cancer development and progression...
  101. pmc Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
    Gyungah Jun
    Department of Medicine, Boston University, USA
    Arch Neurol 67:1473-84. 2010
    To determine whether genotypes at CLU, PICALM, and CR1 confer risk for Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by apolipoprotein E (APOE) genotypes.

Research Grants67

  1. MICHAEL PATRICK MURPHY; Fiscal Year: 2016
    ..Critical limb ischemia (CLI) results in at least 50,000 amputations annually, with a cost estimated at $4.3 billion/year...
  2. Kenneth Rosenfield; Fiscal Year: 2016
    ..to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for assessing comparative effectiveness...
  3. Flora Sandra Siami; Fiscal Year: 2016
    ..to prevent mortality, limb-amputation or further revascularization in a target limb with critical limb ischemia (CLI), meeting the current mandate for assessing comparative effectiveness...
  4. Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative Cells
    Erik J Woods; Fiscal Year: 2010
    ..universal donor, cell therapy for an advanced form of peripheral artery disease termed "critical limb ischemia" (CLI). The major problem facing CLI patients is lack of proper circulation to the extremities...
  5. Laura J Suggs; Fiscal Year: 2015
    ..This end result, termed critical limb ischemia (CLI), is treated surgiclly or endoscopically in an effort to enhance blood flow to the limb...
  6. Raj Kishore; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Critical limb ischemia (CLI) imposes a major public health burden, resulting in high rates of death and disability. Thus far no medical therapy has been shown to ameliorate CLI...
  7. RAYMOND QUEZON MIGRINO; Fiscal Year: 2015
    ..Among many therapeutic cargos that can be conjugated to NLs, clusterin (also known as apolipoprotein J) has promising potential to protect against amyloid protein cell injury...
  8. Unifying Mechanisms of Neurological Disorders: Scientific, Translational, and Cli
    JOAN MARIE CRANMER; Fiscal Year: 2010
    ..NEUROTOXICOLOGY 26 will focus on common mechanisms in neurological disease and the role of environmental exposures and gene-environment interactions in the development of neurological disease and disorders. ..
  9. Robyn A Honea; Fiscal Year: 2015
    ..gene by environment interactions, we have identified several candidate genes associated with AD risk (BDNF, APOE, CLU, PICALM, CR1, TOMM40) 21, 22, and will take them through a three-step process...
  10. Sanford A Stass; Fiscal Year: 2016
    ..including immunohistochemistry, clinical chemistry, molecular diagnostics, flow cytometry, cytogenetics, and a CLI/VCAP, GLP compliant histopathology laboratory...
  11. MEGAN A FETTIG; Fiscal Year: 2014
    ..neurons located within the periaqueductal gray (PAG) and the rostral and caudal linear nuclei of the raphe (RLi and CLi)...
  12. Asrar B Malik; Fiscal Year: 2016
    ..abstract_text> ..
  13. Genetic Analysis of EGFRvIII-independent Glioblastoma Maintenance
    TIFFANY ELIZABETH TAYLOR; Fiscal Year: 2013
    ..From this screen, the focus was directed toward two apoptosis-related genes: Aurora kinase A (AURKA) and Clusterin (CLU)...
  14. Anne Laure Perraud; Fiscal Year: 2014
    ..of the novel Ca2+-mobilizing second messenger ADP-ribose (ADPR), and of its effector molecule, the ADPR-gated TRPM2 ion channel...
  15. Alzheimer's Abeta, apolipoproteins and blood-brain barrier
    Berislav V Zlokovic; Fiscal Year: 2013
    ..between apolipoprotein (apo) E and the low density lipoprotein receptor (LDLR) and the interactions between apoJ and LDLR-related protein 2 (LRP2) regulate A[unreadable] clearance from brain and its retention in the CNS...
  16. Exercise Dose-Response Effects in Prediabetes: Responses and Mechanisms
    William E Kraus; Fiscal Year: 2013
    ..of these three exercise-only interventions by comparing them to a six-month clinical lifestyle intervention (CLI) that contains the components of the DPP but which is of much shorter duration...
  17. Santiago Partida-Sanchez; Fiscal Year: 2014
    ..i) Exclusive localization of functional Ca2+-permeant melastatin-related transient receptor potential channel (TRPM2) in endolysosomal compartments of DCs...
  18. JOSEPH B ROGERS; Fiscal Year: 2015
    ..the third highest association with genetic risk for Alzheimer's disease (AD), following only ApoE and ApoJ. Three non-overlapping GWAS efforts have confirmed a highly significant CR1 SNP association with AD risk...
  19. Paul M Thompson; Fiscal Year: 2016
    ..Carriers of a common AD risk gene (CLU) have deficits in white matter integrity even as young adults and AD pathology may later exploit this vulnerability...
  20. TIMOTHY CONRAD JENKINS; Fiscal Year: 2016
    ..In summary, the proposed research will provide essential data to move the field of SSTI research forward while facilitating Dr. Jenkins'development into an independently funded investigator. ..
  21. Simon R Cherry; Fiscal Year: 2015
    ..has led to the development of a new hybrid molecular imaging modality known as Cerenkov luminescence imaging (CLI) that allows the spatial distribution of biomolecules labeled with ?-emitting radionuclides to be imaged in vivo ..
  22. Steven G Younkin; Fiscal Year: 2016
    ..Variants in two genetic loci that play roles in the complement cascade, CR1 and CLU, show significant genetic associations with AD, and rare coding variants in TREM2 also confer substantial risk for ..
  23. Richard P Mayeux; Fiscal Year: 2016
    ..to validate and quantify the clinical impact of these newly identified genetic risk factors, namely SNPs in PICALM, CLU, BIN1, MS4A gene clusters, CD33, CD2AP, ABCA7 and EPHA1 using the multiplex families recruited through the National ..
  24. Susan M Kegeles; Fiscal Year: 2016
    ..Research suggests that HIV+ YBMSM engage in the CC far less than others. A community-level intervention (CLI) to build and mobilize communities of YBMSM to support HIV+ men to engage in the CC, decrease psychosocial barriers ..
  25. Dihydrodiol dehydrogenase mediates cisplatin resistance
    Henry Simpkins; Fiscal Year: 2007
    ..Four genes were found to be upregulated in the cisplatin-resistant ceils: tropomyosin, apolipoprotein J (clusterin), glucose dehydrogenase and dihydro dehydrogenase...
  26. UCLA Graduate Training Progams in Translational and Cli*
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2010
    ..Educators from the UCLA Center for Educational Development and Research have implemented performance evaluation mechanisms to tssess the quality and outcomes of the program for the purposes of continuous improvement. ..
  27. M Ilyas Kamboh; Fiscal Year: 2016
    ..have identified significant associations of LOAD with SNPs in nine additional loci, including, ABCA7, MS4A4, EPHA1, CLU, CR1, PICALM, BIN1, CD2AP and CD33 and all, but CR1 and CD2AP, have been replicated in our GWAS sample...
  28. ALCOHOL, APOLIPOPROTEIN-J BIOCHEMISTRY, AND HDL FUNCTION
    Pradeep Ghosh; Fiscal Year: 1999
    ..Recently, Apo J, a 70-kDa protein has been identified as an integral component of human plasma HDL and its role in the reverse ..
  29. STRUCTURE/FUNCTION OF ALZHEIMERS AMYLOID-B AGGREGATES
    GRANT KRAFFT; Fiscal Year: 2000
    ..to characterize structural aspects of AB interactions with two other plaque components, apolipoprotein E (apoE) and apoJ, which are elevated in AD brain tissue...
  30. PROSTATIC REGRESSION--DEVELOPMENTAL APPROACH
    Gerald Cunha; Fiscal Year: 1992
    ..All specific aims will be examined through use of both normal and neoplastic prostatic tissue...
  31. ONTOGENY OF DEPRESSIVE SUBSTRATES
    Pingfu Feng; Fiscal Year: 2001
    ..In past work investigator found that if neonatal rats were treated with clomipramine (CLI) and other antidepressant drugs they developed signs of depression when they became adults...
  32. Apoj/Clusterin:A Protective Protein In Vascular Biology
    NORMAN GRANHOLM; Fiscal Year: 2005
    ..Our Preliminary Results suggest that apolipoprotein (apo) J / clusterin may be an important regulator in determining the vascular response to injury and the development of the ..
  33. RENAL GROWTH/DURING URETERAL OBSTRUCTION
    Ihor Sawczuk; Fiscal Year: 1993
    ..In either case, it is a fascinating marker of tissue degeneration and atrophy. Antibodies will be produced in order to determine its cellular localization and other physical characteristics of the TRPM-2 protein product...
  34. Berislav V Zlokovic; Fiscal Year: 2016
    ..AB is implicated in the neuropathology of AD and related disorders. Apolipoproteins J and E (apoJ, apoE) co-localize with the senile plaques and congophilic angiopathy of AD...
  35. Breast Cancer Therapy by Differentiation Gene Activation
    Irma Russo; Fiscal Year: 2006
    ..the synthesis of inhibin, a secreted protein with tumor suppressor activity, and activation of the apoptotic genes TRPM2, ICE, p53, c-myc, WAF-1 /CIP-1, bcI-XS, and p53...
  36. COMPLEMENT EXPRESSION IN ALZHEIMER'S DISEASE BRAIN
    Steven Johnson; Fiscal Year: 1993
    ..We found several C component mRNAs up-regulated in AD brain, including SGP-2/CLI, an inhibitor of the C5b-9 membrane attack complex...
  37. SGP-2 (CLUSTERIN) AND REPRODUCTION
    Michael Griswold; Fiscal Year: 2003
    b>Clusterin is the major protein secreted by cultured Sertoli cells. Clusterin is heavily glycosylated protein consisting of disulfide linked heteromonomers and is expressed by many cells but primarily by those of epithelial origin...
  38. The Role of ADAM15 in sTie2 shedding in Ischemic Angiogenesis
    Daniel Corey; Fiscal Year: 2009
    ..To date, the role of elevated sTie2 in CLI and other disease states is not known, and whether ADAM15 is involved in sTie2 shedding in vivo remains unclear...
  39. INHIBITION AND MECHANISM OF AMYLOID BETA-AGGREGATION
    Michael Zagorski; Fiscal Year: 2004
    ..inhibitor bindings sites or surfaces, Aim 3 will conduct NMR binding studies with macromolecules (such as ApoE and ApoJ) and presumed amyloid inhibitors with monomeric Abeta (1-40) and Abeta (1-42)...
  40. SUPRAMOLECULAR A/BETA--GLIAL INTERACTIONS & CELL RESPONS
    Linda Van Eldik; Fiscal Year: 1999
    ..on the levels and activity of six relevant glial proteins: a 1-antichymotrypsin (ACT), apolipoprotein E (apoE), apoJ, butyrylcholinesterase (BChE), interleukin-1 (IL-1), and S100 beta ...
  41. Novel A-beta mutation associated with familial CAA
    G Rebeck; Fiscal Year: 2001
    ..We will examine whether mutant Abeta fibrillogenesis is altered by binding proteins (apoE, apoJ) and cations (calcium, iron) and test whether Abeta exhibits altered toxicity towards smooth muscle cells in vitro...
  42. REGULATION OF AN EXTRACELLULAR XENOBIOTIC RESPONSE GENE
    Bruce Aronow; Fiscal Year: 1999
    ..b>ApoJ, an evolutionarily conserved secretory glycoprotein capable of binding diverse hydrophobic molecules, has been ..
  43. CLUSTERIN--AN ANTI APOPTOTIC MEDIATOR IN PROSTATE CANCER
    Chung Lee; Fiscal Year: 2004
    ..Clusterin has many names, including sulfated glycoprotein-2 (SGP-2), apolipoprotein J (Apo-J), complement lysis inhibitor (CLI), testosterone repressed prostate message-2 (TRPM-2), etc...
  44. LUPUS NEPHRITIS: ROLE OF ENVIORM. & OCCUPATIONAL EXP.
    MARY DOOLEY; Fiscal Year: 2000
    ..Using study subjects from the Carolina Lupus Study (CLU) and from the Glomerular Disease Collaborative Network (GDCN), this proposal has two aims: 1...
  45. ApoJ (Clusterin) in Alzheimer's Disease and Aging
    Caleb Finch; Fiscal Year: 2006
    b>Apolipoprotein J (clusterin, SGP-2) expression is increased during Alzheimer disease (AD) and to a lesser extent during normal brain again. New data shows that apoL can activate microglia in vivo and in vitro...
  46. DOPAMINERGIC AND BASAL GANGLIA PLASTICITY IN AGING
    THOMAS MCNEILL; Fiscal Year: 2002
    ..In addition, we will analyze the expression of several recently discovered genes, including apoJ, SCG-10, BDNF, GDNF, which seem to play key roles in processes determining cell survival and plasticity...
  47. XIP8, AN X RAY INDUCIBLE KU70 BINDING PROTEIN
    David Boothman; Fiscal Year: 2001
    ..e., testosterone repressed message-2 (TRPM-2)/apolipoprotein J (ApoJ)], a protein that strongly associate with the Ku780 DSB repair protein...
  48. Functional Outcome of Critical Limb Ischemia
    Gregory Landry; Fiscal Year: 2009
    ..The proposed research focuses on functional outcomes of patients undergoing treatment for critical limb ischemia (CLI)...
  49. Enhanced VEGF Gene Transfer for Critical Limb Ischemia
    Edward Nolan; Fiscal Year: 2003
    Angiogenic gene transfer is currently being investigated in clinical trials to treat critical limb ischemia (CLI)...
  50. SIALIC ACID DEFICIENT APOJ (SDJ)--ALCOHOL INTAKE MARKER
    Raj Lakshman; Fiscal Year: 2000
    ..The applicants have demonstrated the validity and feasibility of the use of sialic acid deficiency of plasma Apolipoprotein J(SDJ) as a biological marker for alcohol consumption in rats...
  51. Endothelial Cell Regulation of Smooth Muscle Phenotype
    Richard Powell; Fiscal Year: 2007
    ..abstract_text> ..
  52. 1H MRSI OF AMYOTROPHIC LATERAL SCLEROSIS
    Michael Weiner; Fiscal Year: 2002
    ..abstract_text> ..
  53. Varian 4 Tesla MRI/MRS for Neuro-degenerative Diseases
    Michael Weiner; Fiscal Year: 2002
    ..These expected results emphasize the practical outcome and significance of this research. ..
  54. GENETIC ENGINEERING OF A FAILURE RESISTANT VEIN GRAFT
    Michael Conte; Fiscal Year: 2003
    ..The long term objective is to develop a safe, efficient, and effective protocol for intraoperative gene therapy that will engineer vein bypass grafts that are resistant to occlusion. ..
  55. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara Miller; Fiscal Year: 2007
    ..abstract_text> ..
  56. CALCIUM SIGNALING ACTIVATION PROCESS OF MICROGLIA CELLS
    Reinhold Penner; Fiscal Year: 2005
    ..abstract_text> ..
  57. Molecular and functional properties of the TRPM2 catioin channel
    Reinhold Penner; Fiscal Year: 2010
    ..We identified TRPM2, a member of the TRP family, as a calcium-permeable cation channel gated by the novel second messenger ADP-ribose (..
  58. NSAID Inhibition of Alzheimer Pathology: Role of DHA
    Gregory M Cole; Fiscal Year: 2010
    ..Understanding dietary fatty acid /Abeta-related PAK complex deficits and downstream synaptic defects will reveal a poorly studied overlap between cognitive deficits in mental retardation syndromes and AD with therapeutic implications. ..
  59. Molecular mechanisms of vertebrate Mg2+ homeostasis
    Andrew Scharenberg; Fiscal Year: 2009
    ..Together, the proposed studies will generate a foundation of knowledge on the molecular mechanisms of Mg uptake and their integration with mechanisms which regulate cell growth and proliferation. ..
  60. Characterization of a novel metal ion permeable channel
    Meredith Hermosura; Fiscal Year: 2006
    ..These mutations will be then engineered in the expression system to assess resulting alterations in channel function. ..
  61. Targeted gene repair of primary immune deficiencies
    Andrew Scharenberg; Fiscal Year: 2006
    ..Overall, the work proposed here will build a foundation of materials and experience for the development of LHE's as general tools for targeted gene therapy of human primary immune deficiencies. ..
  62. TRPM2 HTS Screening Assay Development(RMI)
    Andrew Scharenberg; Fiscal Year: 2005
    The TRPM2 Ca2+-permeable cation channel opens in response to binding of ADP-ribose to a well defined C-terminal gating domain...
  63. ANALYSIS OF B-CELL RECEPTOR CALCIUM SIGNALING
    Andrew Scharenberg; Fiscal Year: 2004
    ..abstract_text> ..

Patents1

  1. CYTOLYSIS INHIBITOR PROTEINS (CLI) AND DNA SEQUENCES CODING FOR SAID PROTEINS
    Patent Number: WO9105043-A1; Date:1991-04-18