CLCA4

Summary

Gene Symbol: CLCA4
Description: chloride channel accessory 4
Alias: CaCC, CaCC2, calcium-activated chloride channel regulator 4, caCC-2, calcium-activated chloride channel family member 4, calcium-activated chloride channel protein 2, chloride channel regulator 4, chloride channel, calcium activated, family member 4, hCLCA4, hCaCC-2
Species: human

Top Publications

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
  2. ncbi Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
    M Agnel
    Synthelabo Recherche, Genomic Biology Department, Rueil Malmaison, France
    FEBS Lett 455:295-301. 1999
  3. ncbi The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis
    Margit Ritzka
    Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hum Genet 115:483-91. 2004
  4. pmc CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine
    Ernst Wolfgang Kolbe
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 21:691-4. 2013
  5. doi Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats
    Vinod D Ramteke
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, U P, 243 122, India
    Pharmacol Biochem Behav 91:417-22. 2009
  6. pmc Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
    Kuai Yu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1722-35. 2010
  7. doi House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia
    Hyung Ju Cho
    Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
    J Cell Biochem 109:1254-63. 2010
  8. pmc A high-throughput data mining of single nucleotide polymorphisms in Coffea species expressed sequence tags suggests differential homeologous gene expression in the allotetraploid Coffea arabica
    Ramon Oliveira Vidal
    Laboratório de Genômica e Expressão, Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, CEP 13083 970, Campinas SP, Brazil
    Plant Physiol 154:1053-66. 2010
  9. ncbi Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    Ricardo de la Fuente
    1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
    Mol Pharmacol 73:758-68. 2008
  10. ncbi Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine
    I Hatip-Al-Khatib
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, P O Box 33, 20027, Denizli, Turkey
    Brain Res 902:108-18. 2001

Research Grants

  1. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
  2. Development of inhibitors of the calcium-activated chloride channel TMEM16a
    Marc O Anderson; Fiscal Year: 2013
  3. Lily Y Jan; Fiscal Year: 2016
  4. TMEM16A Channel Stoichiometry and Subunit Interaction
    Jason Tien; Fiscal Year: 2013
  5. Renzhi Han; Fiscal Year: 2016
  6. Investigating the neuronal physiology of TMEM16A Ca++ activated Cl- channels
    JAMES BERG; Fiscal Year: 2012
  7. THOMAS JOHN BRETT; Fiscal Year: 2016
  8. H Criss Hartzell; Fiscal Year: 2016
  9. Thomas L Pallone; Fiscal Year: 2014
  10. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012

Detail Information

Publications154 found, 100 shown here

  1. pmc HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation
    Q H Liu
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 97:4832-7. 2000
    ..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection...
  2. ncbi Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
    M Agnel
    Synthelabo Recherche, Genomic Biology Department, Rueil Malmaison, France
    FEBS Lett 455:295-301. 1999
    ..Another original feature as compared to the CaCC family members is the fact that hCaCC-2 also shows expression in the brain...
  3. ncbi The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis
    Margit Ritzka
    Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hum Genet 115:483-91. 2004
    ..Transmission disequilibrium and the significance of the association decreased within the locus from hCLCA2 towards hCLCA4. Expression of hCLCA1 and hCLCA4 in human rectal mucosa was proven by microarray analysis...
  4. pmc CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine
    Ernst Wolfgang Kolbe
    Department of Pediatrics, Hannover Medical School, Hannover, Germany
    Eur J Hum Genet 21:691-4. 2013
    ..The manifestation of the basic defect was associated with markers rs11807298-rs6684219, encompassing the CLCA4 promoter (Praw=0.0013; Pcorr=0.0157)...
  5. doi Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in rats
    Vinod D Ramteke
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, U P, 243 122, India
    Pharmacol Biochem Behav 91:417-22. 2009
    ..injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel opener and NPPB, a CaCC blocker. The effect of ivermectin (5, 10, 20 mg/kg i.p. or 50, 100 and 200 microg/rat by i.c.v...
  6. pmc Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
    Kuai Yu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1722-35. 2010
    ..Here we investigated the role of a candidate CaCC protein, bestrophin-2 (Best2), using Best2-/- mice...
  7. doi House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epithelia
    Hyung Ju Cho
    Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
    J Cell Biochem 109:1254-63. 2010
    ..both a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and a Ca(2+)-activated Cl(-) channel (CaCC) inhibitor. HDM extract also stimulated fluid secretion from porcine airway mucosa...
  8. pmc A high-throughput data mining of single nucleotide polymorphisms in Coffea species expressed sequence tags suggests differential homeologous gene expression in the allotetraploid Coffea arabica
    Ramon Oliveira Vidal
    Laboratório de Genômica e Expressão, Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, CEP 13083 970, Campinas SP, Brazil
    Plant Physiol 154:1053-66. 2010
    ..The assignment of the C. arabica haplotypes to the C. canephora (CaCc) or C...
  9. ncbi Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel
    Ricardo de la Fuente
    1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
    Mol Pharmacol 73:758-68. 2008
    ..Potent, selective CaCC inhibitors have not been available...
  10. ncbi Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpine
    I Hatip-Al-Khatib
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, P O Box 33, 20027, Denizli, Turkey
    Brain Res 902:108-18. 2001
    ..585+/-0.01 fmol/microl), low 5-HT (0.334+/-0.032 fmol/microl) and high DOPAC/DA ratio (265.11+/-20.73) in intact cACC. 6-OHDA alone (8 microg/2 microl) depleted DA (-66%), DOPAC (-65%), and NE (-62%)...
  11. ncbi Dynamic sorption of ionizable organic compounds (IOCs) and xylene from water using geomaterial-modified montmorillonite
    M Houari
    Departement of Chemical Engineering, University of Blida, P O Box 270 09000 Blida, Algeria
    J Hazard Mater 147:738-45. 2007
    ..and fixed-bed column studies were undertaken to evaluate the performance of clay-active coal-coated cement (CACC) in removing phenols from aqueous solution...
  12. doi Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline
    John W Funder
    Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
    J Clin Endocrinol Metab 93:3266-81. 2008
    ..Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism...
  13. pmc In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction
    E C Strauss
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Mol Cell Biol 12:2135-42. 1992
    ..on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon ..
  14. ncbi Structure of the L-histidine decarboxylase gene
    K Yatsunami
    Japan Tobacco Inc, Pharmaceutical Basic Research Laboratories, Yokohama
    J Biol Chem 269:1554-9. 1994
    ..We found a TATA-like sequence, a GC box, four CACC boxes, four GATA consensus sequences, and six leader-binding protein-1 binding motifs in the promoter region of the ..
  15. pmc Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
    Wan Namkung
    Department of Medicine, University of California, San Francisco, CA 94143 0521, USA
    FASEB J 24:4178-86. 2010
    TMEM16A was found recently to be a calcium-activated Cl(-) channel (CaCC)...
  16. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009
    ..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
  17. ncbi Chloride transport in NCL-SG3 sweat gland cells: channels involved
    Z Servetnyk
    Department of Medical Cell Biology, Uppsala University, Box 571, SE 751 23 Uppsala, Sweden
    Exp Mol Pathol 83:47-53. 2007
    ..Ca(2+)-activated chloride conductance is confirmed and the putative Ca(2+)-activated chloride channel (CaCC) is further characterized in term of its pharmacological sensitivity...
  18. ncbi Identification of novel, cardiac-restricted transcription factors binding to a CACC-box within the human cardiac troponin I promoter
    K A Dellow
    Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
    Cardiovasc Res 50:24-33. 2001
    ..In analysing the putative binding elements within the proximal promoter, a CACC-box sequence overlapping a consensus Sp1 element has been identified...
  19. ncbi Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis study
    I Hatip-Al-khati
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Jpn J Pharmacol 87:277-87. 2001
    ..and extracellular amines concentration by 6-hydroxydopamine (6-OHDA)-induced lesion of core nucleus accumbens (cACC) of rats...
  20. ncbi The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression
    C M Li
    Department of Human Genetics, Mount Sinai School of Medicine, New York 10029, USA
    Genomics 62:223-31. 1999
    ..several sequences matching transcription factor binding sites, including nine SP-1 sites, one AP-1 site, and three CACC boxes...
  21. ncbi The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesis
    D Treichel
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 101:175-9. 2001
    ..characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the promoter of many genes...
  22. ncbi Pain dynamics observed by functional magnetic resonance imaging: differential regression analysis technique
    Zang Hee Cho
    Department of Radiological Sciences, University of California, Irvine, California 92697, USA
    J Magn Reson Imaging 18:273-83. 2003
    ..To observe the dynamic responses of the cortical areas related to the pain processing by using the differential regression analysis (DRA) technique in functional magnetic resonance imaging (fMRI) and investigation of pain mechanisms...
  23. pmc Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27708, USA
    J Biol Chem 284:14875-80. 2009
    ..CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC...
  24. pmc Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
    Sung Jin Hwang
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 587:4887-904. 2009
    ..Several conductances, such as Ca(2+)-activated Cl() channels (CaCC) and non-selective cation channels (NSCC) have been suggested to be involved in slow wave depolarization...
  25. pmc Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells
    Victor G Romanenko
    Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 285:12990-3001. 2010
    Activation of an apical Ca(2+)-dependent Cl(-) channel (CaCC) is the rate-limiting step for fluid secretion in many exocrine tissues...
  26. ncbi Environmental factors promoting the effective use of a computer-assisted clinical case for second-year osteopathic medical students
    R W Baer
    Department of Physiology, Kirksville College of Osteopathic Medicine, USA
    J Am Osteopath Assoc 98:380-5. 1998
    Computer-aided clinical cases (CACC) have the potential to complement and/or supplement other types of problem-based learning exercises in modern medical curricula...
  27. ncbi Effect of NYD-SP27 down-regulation on ATP-induced Ca2+-dependent pancreatic duct anion secretion in cystic fibrosis cells
    Jin Xia Zhu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Rm 410, Basic Medical Science Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cell Biol Int 31:521-5. 2007
    ..The inhibitor of adenylate cyclase, MDL12330A (20 microM), and Ca(2+)-dependent Cl(-) channel (CaCC) blocker, DIDS (100 microM) also significantly reduced the basal current in AT-CF...
  28. doi Cloning and characterization of a calcium-activated chloride channel in rat uterus
    Junfang Song
    Institute of Genetics and Developmental Biology and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Biol Reprod 80:788-94. 2009
    ..in regulation of uterine contractility, we cloned a novel calcium-activated chloride channel gene, named rat Clca4, from pregnant rat uterus...
  29. ncbi Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene
    J F Medina
    Department of Medicine, University Clinic and Medical School, University of Navarra, Pamplona, Spain
    Genomics 39:74-85. 1997
    ..These features, as well as the presence of several consensus elements such as GATA, LBP-1, E-box, CACC box, and T-antigen motif, indicate that the human AE2 promoter resembles the erythroid promoter of the human AE1 ..
  30. ncbi Expression and biological significance of Ca2+-activated ion channels in human keratinocytes
    H Koegel
    Department of Physiology, University of Munich, D 80336 Munich, Germany
    FASEB J 15:145-154. 2001
    ..data, RT-PCR showed that HaCaT keratinocytes express two types of Ca2+-activated Cl- channels, CaCC2 and CaCC3 (CLCA2), as well as the Ca2+-activated K+ channel hSK4...
  31. pmc EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2
    Michael R Tallack
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia
    J Biol Chem 284:20966-74. 2009
    ..We found and validated novel intronic enhancers in both the E2f2 and E2f4 genes, which contain conserved CACC, GATA, and E-BOX elements. The E2f2 enhancer was occupied by EKLF in vivo...
  32. pmc Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon
    N S Nanda Kumar
    Depts of Biochemistry and Microbiology, West Virginia Univ School of Medicine, Morgantown, 26506, USA
    Am J Physiol Gastrointest Liver Physiol 299:G707-14. 2010
    ..acid, whereas it was only partially inhibited by CFTR [CFTR(inh)-172, glibenclamide]- and CaCC (niflumic acid)-specific Cl(-) channel blockers...
  33. ncbi myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
    M A Carew
    Inositide Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:26906-13. 2000
    Does inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P(4)) inhibit apical Ca(2+)-activated Cl(-) conductance (CaCC)? We studied this question using human CFPAC-1 pancreatoma cells grown in polarized monolayers...
  34. pmc Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia
    A M Paradiso
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Gen Physiol 117:53-67. 2001
    ..response was mediated exclusively via Ca(2+)(i) interacting with a Ca(2+)-activated Cl(-) channel (CaCC)...
  35. pmc Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway
    Lihua Liang
    Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
    Am J Physiol Cell Physiol 296:C131-41. 2009
    ..developed a screening assay and screened a library for compounds that could enhance cytoplasmic Ca2+, activate the CaCC, and increase Cl(-) secretion...
  36. pmc Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells
    Fadi Aldehni
    Department of Physiology, University of Regensburg, University Street 31, Regensburg 93053, Germany
    J Am Soc Nephrol 20:1556-64. 2009
    ..ii) a loss of amiloride-sensitive Na(+) absorption, iii) induction of Ca(2+)-dependent Cl(-) conductance (CaCC), and iv) epithelial-to-mesenchymal transition...
  37. doi Biomarkers of human gastrointestinal tract regions
    Elena Maria Comelli
    Department of Nutrition and Health, Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
    Mamm Genome 20:516-27. 2009
    ..These include CLCA4 and SLC26A2, both implicated in ion transport...
  38. ncbi TMEM16 proteins: the long awaited calcium-activated chloride channels?
    C A Flores
    Centro de Estudios Cientificos CECS, Valdivia, Chile
    Braz J Med Biol Res 42:993-1001. 2009
    ..by three independent groups, using different strategies, of TMEM16A as the molecular counterpart of the CaCC is discussed. TMEM16A is part of a family that has 10 other members in mice...
  39. pmc Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancer
    Pamela L Beatty
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cancer Prev Res (Phila) 3:438-46. 2010
    ..in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC)...
  40. pmc Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A
    John T Sheridan
    Department of Cell and Molecular Physiology, University of North Carolina, North Carolina, Chapel Hill 27599, USA
    J Biol Chem 286:1381-8. 2011
    ..Ano)/TMEM16A family have recently been identified as essential subunits of the Ca(2+)-activated chloride channel (CaCC)...
  41. doi Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmission
    Maria Sancho
    Dept of Physiology, Veterinary School, Madrid, Spain
    Am J Physiol Renal Physiol 302:F390-400. 2012
    We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR...
  42. pmc Calcium-activated chloride current expression in axotomized sensory neurons: what for?
    Mathieu Boudes
    INSERM U 1051, Sensory Diseases, Neuro plasticity and Therapy, Institut des Neurosciences de Montpellier Montpellier, France
    Front Mol Neurosci 5:35. 2012
    ..Functional screenings of potential candidate genes established that Best1 is a molecular determinant for CaCC expression among axotomized sensory neurons, while Tmem16a is acutely activated by inflammatory mediators in ..
  43. pmc Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network
    Patricia Perez-Cornejo
    Physiology Department, School of Medicine, Universidad Autonoma de San Luis Potosi, San Luis Potosi, SLP 78210, Mexico
    Proc Natl Acad Sci U S A 109:10376-81. 2012
    The newly discovered Ca(2+)-activated Cl(-) channel (CaCC), Anoctamin 1 (Ano1 or TMEM16A), has been implicated in vital physiological functions including epithelial fluid secretion, gut motility, and smooth muscle tone...
  44. doi Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma
    Wen Liu
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, China
    Cancer Lett 326:41-51. 2012
    ..ANO1/TMEM16A was recently identified as a CaCC, and it is of interest to determine whether ANO1 plays a role in development and metastasis of prostate carcinoma...
  45. pmc Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
    Paolo Scudieri
    Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy
    J Physiol 590:6141-55. 2012
    The TMEM16A protein has a potential role as a Ca(2+)-activated Cl(-) channel (CaCC) in airway epithelia where it may be important in the homeostasis of the airway surface fluid...
  46. doi Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasis
    Tero M Viitanen
    Department of Biosciences, Abo Akademi University, Turku, Finland
    J Cell Physiol 228:814-23. 2013
    ..Our whole-cell voltage clamp recordings revealed the presence of a Ca(2+) activated Cl(-) current (CaCC) in Fisher rat thyroid cell line 5 (FRTL-5)...
  47. pmc GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells
    Fanning Zeng
    Gastrointestinal Disease Area, Novartis Horsham Research Centre, Horsham, United Kingdom
    PLoS ONE 7:e47686. 2012
    ..This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression...
  48. doi Purinergic regulation of CFTR and Ca(2+)-activated Cl(-) channels and K(+) channels in human pancreatic duct epithelium
    Jing Wang
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Cell Physiol 304:C673-84. 2013
    ..Apically applied ATP/UTP stimulated CF transmembrane conductance regulator (CFTR) and Ca(2+)-activated Cl(-) (CaCC) channels, which were inhibited by CFTRinh-172 and niflumic acid, respectively...
  49. doi Computed tomography and echocardiography together reveal more high-risk findings than echocardiography alone in the diagnostics of stroke etiology
    Petri Sipola
    Department of Clinical Radiology, Diagnostic Imaging Centre, Neuro Center, Kuopio University Hospital, Kuopio, Finland
    Cerebrovasc Dis 35:521-30. 2013
    ..We investigate whether combined examination of the heart, aorta, and cervicocranial arteries with computed tomography (CACC-CT) may improve the diagnosis of stroke etiology.
  50. pmc Chloride channel-targeted therapy for secretory diarrheas
    Jay R Thiagarajah
    Departments of Medicine and Physiology, University of California, San Francisco, CA 94143 0521, USA Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Pharmacol 13:888-94. 2013
    ..High-throughput screens have yielded several chemical classes of small molecule CFTR and CaCC inhibitors that show efficacy in animal models of diarrheas...
  51. pmc MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1
    Soo Jin Oh
    Center for Neuroscience and Center for Functional Connectomics, Brain Science Institute S J O, J J, J K, J Y C, C J L, and Chemical Kinomics Research Center, Future Convergence Research Division S J H, E J R, Korea Institute of Science and Technology KIST, Seoul, Korea Neuroscience Program, University of Science and Technology, Daejeon, Korea C J L KU KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Korea C J L and Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia K Y, H C H
    Mol Pharmacol 84:726-35. 2013
    ..widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions...
  52. doi Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytes
    Ren Gong Zhuo
    Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    J Physiol Biochem 70:185-91. 2014
    ..However, protein kinase C inhibitor did not display any visible effect on CaCC currents...
  53. pmc Activation and inhibition of TMEM16A calcium-activated chloride channels
    Yu Li Ni
    Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California, United States of America
    PLoS ONE 9:e86734. 2014
    Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride ..
  54. ncbi Modulation of TMEM16A-channel activity as Ca²⁺ activated Cl⁻ conductance via the interaction with actin cytoskeleton in murine portal vein
    Junya Ohshiro
    Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Pharmacol Sci 125:107-11. 2014
    TMEM16A is a major component of Ca(2+)-activated Cl(-) channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs...
  55. doi Functional role of the Ca²⁺-activated Cl⁻ channel DOG1/TMEM16A in gastrointestinal stromal tumor cells
    Erik Berglund
    Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm, Sweden Electronic address
    Exp Cell Res 326:315-25. 2014
    DOG1, a Ca(2+)-activated Cl(-) channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST)...
  56. pmc Characterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias
    Zhen Ye
    Departments of Clinical Pharmacy and Cardiology, The 2nd Affiliated Hospital, Harbin Medical University, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, P R China
    J Cell Physiol 230:337-46. 2015
    Anoctamin1 (ANO1) encodes a Ca(2+)-activated chloride (Cl(-)) channel (CaCC) in variety tissues of many species. Whether ANO1 expresses and functions as a CaCC in cardiomyocytes remain unknown...
  57. doi Evidence for the participation of Ca(2+)-activated chloride channels in formalin-induced acute and chronic nociception
    Guadalupe Garcia
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Cinvestav, Sede Sur México, D F, Mexico
    Brain Res 1579:35-44. 2014
    In this study we determined the role of Ca(2+)-activated chloride channels (CaCC) in acute and chronic nociceptive responses elicited by 1% formalin. Formalin injection produced a typical pattern of flinching behavior for about 1h...
  58. pmc In silico determination of the effect of multi-target drugs on calcium dynamics signaling network underlying sea urchin spermatozoa motility
    Jesús Espinal-Enríquez
    Instituto de Ciencias Fisicas, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, México Centro de Ciencias de la Complejidad, Ciudad Universitaria, Mexico, México Instituto Nacional de Medicina Genómica, Arenal Tepepan, Tlalpan, Mexico
    PLoS ONE 9:e104451. 2014
    ..NFA are: hyperpolarization-activated and cyclic nucleotide gated Na+ channels (HCN), [Ca2+]-dependent Cl- channels (CaCC) and [Ca2+]-dependent K+ channels (CaKC), all present in the sea urchin genome...
  59. pmc Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells
    Yujie Sui
    Key Laboratory for Molecular and Chemical Genetics of Critical Human Diseases of Jilin Province, Jilin University Bethune Second Hospital, Changchun, P R China
    PLoS ONE 9:e115443. 2014
    ..TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be overexpressed in several malignancies; however, its expression and function in colorectal ..
  60. pmc A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland
    Marcelo A Catalán
    Secretory Mechanisms and Dysfunction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 112:2263-8. 2015
    Activation of an apical Ca(2+)-activated Cl(-) channel (CaCC) triggers the secretion of saliva...
  61. pmc TRPC1 regulates calcium-activated chloride channels in salivary gland cells
    Yuyang Sun
    Department of Basic Sciences, School of Medicine Health Sciences, University of North Dakota, Grand Forks, North Dakota
    J Cell Physiol 230:2848-56. 2015
    Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion...
  62. doi Uterine Contractility in the Nonpregnant Mouse: Changes During the Estrous Cycle and Effects of Chloride Channel Blockade
    Kelsi N Dodds
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 92:141. 2015
    ..It is unlikely that this conductance is generated by the Ca(2+)-activated Cl(-) channels, anoctamin-1 and CLCA4, as immunohistochemical labeling did not reveal protein expression within muscle or pacemaker cell networks...
  63. doi Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppers
    Pawin Pongkorpsakol
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Ratchathewee, Bangkok, Thailand
    Pharmacol Res 100:271-80. 2015
    ..Piperine suppressed Ca2+-activated Cl- channels (CaCC) without affecting intracellular Ca2+ concentrations or Ca2+-activated basolateral K+ channels...
  64. doi Deciphering the regulon of a GntR family regulator via transcriptome and ChIP-exo analyses and its contribution to virulence in Xanthomonas citri
    Xiaofeng Zhou
    Citrus Research and Education Center, Department of Microbiology and Cell Science, IFAS, University of Florida, 700 Experiment Station Road, Lake Alfred, FL, 33850, USA
    Mol Plant Pathol 18:249-262. 2017
    ..analysis revealed that YtrA directly regulates three operons by binding to a palindromic motif GGTG-N16 -CACC at the promoter region...
  65. doi Surface expression of the Anoctamin-1 (ANO1) channel is suppressed by protein-protein interactions with β-COP
    Young Sun Lee
    School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 02841, Republic of Korea Center for Functional Connectomics, Korea Institute of Science and Technology KIST, Seoul 02792, Republic of Korea
    Biochem Biophys Res Commun 475:216-22. 2016
    Anoctamin-1 (ANO1) is a Ca(2+)-activated chloride channel (CaCC) that plays important physiological roles in normal and cancerous tissues. However, the plasma membrane trafficking mechanisms of ANO1 remain poorly characterized...
  66. pmc Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymis
    Da Yuan Gao
    School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
    J Gen Physiol 148:161-82. 2016
    ..and pharmacological data also reveal a constitutively active calcium-activated chloride conductance (CaCC). Removal of extracellular calcium attenuates not only the TRPV6-like conductance, but also the CaCC...
  67. doi Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channels
    Isabella Salzer
    Centre for Physiology and Pharmacology, Medical University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
    Neuropharmacology 110:277-86. 2016
    ..5HT2C receptor blocker only, and the current was prevented by an inhibitor of Ca(2+)-activated chloride channels (CaCC)...
  68. doi Ca2+-activated Cl- channel currents in mammary secretory cells from lactating mouse
    Akihiro Kamikawa
    Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan and
    Am J Physiol Cell Physiol 311:C808-C819. 2016
    The Cl- secretion via Ca2+-activated Cl- channel (CaCC) is critical for fluid secretion in exocrine glands like the salivary gland...
  69. doi Evaluation of the impacts of cooperative adaptive cruise control on reducing rear-end collision risks on freeways
    Ye Li
    School of Transportation, Southeast University, 2 Si Pai Lou, Nanjing, 210096, PR China Electronic address
    Accid Anal Prev 98:87-95. 2017
    Although plenty of studies have been conducted recently about the impacts of cooperative adaptive cruise control (CACC) system on traffic efficiency, there are few researches analyzing the safety effects of this advanced driving-assistant ..
  70. pmc Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal
    Mei Hong Zhu
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada
    Am J Physiol Gastrointest Liver Physiol 311:G1037-G1046. 2016
    ..electrical slow waves by coordinated openings of ANO1 channels, a Ca2+-activated Cl- (CaCC) conductance...
  71. pmc Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16A
    Silvia Cruz-Rangel
    Physics Institute, Universidad Autonoma de San Luis Potosi, Ave Dr Manuel Nava 6, San Luis Potosi, SLP, 78290, Mexico
    J Physiol . 2016
    ..These findings are critical for understanding physiological and pathological processes that involve changes in pH and chloride flux via TMEM16A...
  72. pmc Role of Quercetin in Modulating Chloride Transport in the Intestine
    Bo Yu
    Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, School of Life Sciences, Liaoning Normal University Dalian, China
    Front Physiol 7:549. 2016
    ..In this study, we have identified a flavonoid quercetin as a modulator of CaCC chloride channel activity...
  73. doi Anoctamin2 (TMEM16B) forms the Ca2+-activated Cl- channel in the retinal pigment epithelium
    Susanne Keckeis
    Experimental Ophthalmology, Department of Ophthalmology, Charite University Medicine Berlin, Berlin, Germany
    Exp Eye Res . 2016
    ..Ca2+-dependent chloride channels (CaCC) in the RPE were found to adapt Cl- transport to specific needs by increasing intracellular free Ca..
  74. doi Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entry
    Axel R Concepcion
    Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA
    Cell Calcium . 2016
    ..an important, non-redundant role in regulating the function of Ca2+-activated Cl- channels (CaCC), Cl- secretion and sweat production...
  75. pmc A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter
    Chang Yun Gui
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:7009-14. 2003
    ..In contrast, promoter hyperacetylation requires the promoter GATA-1, and CACC-factor activator motifs, as well as the TATA box...
  76. ncbi SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish population
    William T Wright
    Centre for Clinical and Population Science, Queen s University, Belfast BT9 7AB, UK
    Atherosclerosis 185:353-60. 2006
    ..102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26)...
  77. ncbi Construction of pDESTR, a GATEWAY vector for gene disruption in filamentous fungi
    Ayumi Abe
    Laboratory of Applied Microbiology, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, 060 8589, Japan
    Curr Microbiol 52:210-5. 2006
    ..After the amplification with a 5'CACC-tagged primer and an ordinary primer, the DNA fragment will be inserted into pENTR/D-TOPO vector and then ..
  78. doi TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability
    Ta To Tran
    Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    J Cell Physiol 229:181-90. 2014
    ..TMEM16E did not exhibit cell surface calcium-dependent chloride channel (CaCC) activity, which was originally identified in TMEM16A and TMEM16B, due to their intracellular vesicle distribution...
  79. pmc Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels
    Hiroyuki Terashima
    Departments of Anesthesiology, Physiology and Biophysics, and Biochemistry, Weill Cornell Medical College, Cornell University, New York, NY 10065
    Proc Natl Acad Sci U S A 110:19354-9. 2013
    ..Well-characterized CaCC blockers inhibit Cl(-) transport with Kis comparable to those measured for native and heterologously expressed ..
  80. ncbi Specificity of mammalian Y-box binding protein p50 in interaction with ss and ds DNA analyzed with generic oligonucleotide microchip
    O A Zasedateleva
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, 119991 Moscow, Russian Federation
    J Mol Biol 324:73-87. 2002
    ..The binding of p50 to the generic microchip was shown to be the most specific to ss GGGG motif and then to ss CACC and CATC motifs...
  81. ncbi Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epithelium
    Hazel Atherton
    Novartis Respiratory Research Centre, Wimblehurst Road, Horsham, West Sussex, UK
    Naunyn Schmiedebergs Arch Pharmacol 367:214-7. 2003
    ..short circuit current (ISC) and the appearance of an enhanced calcium-activated chloride conductance (CaCC)...
  82. ncbi Role of Ca2+-activated Cl- channels in the mechanism of apoptosis induced by cyclosporin A in a human hepatoma cell line
    Jung Ae Kim
    College of Pharmacy, Yeungnam University, Gyongsan 712 749, South Korea
    Biochem Biophys Res Commun 309:291-7. 2003
    ..Treatment with these CaCC inhibitors (NA, FA, NPPB, and DIDS) markedly prevented the CsA-induced apoptosis...
  83. pmc Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle
    George Gallos
    Dept of Anesthesiology, 622 W 168th St P and S Box 46, Columbia Univ College of Physicians and Surgeons, New York, NY 10032
    Am J Physiol Lung Cell Mol Physiol 305:L625-34. 2013
    ..Although calcium-activated chloride channel (CaCC) flux has been described in many cell types, including human airway smooth muscle (HASM), the true molecular ..
  84. pmc A simple method for the preparation of crude gintonin from ginseng root, stem, and leaf
    Mi Kyung Pyo
    International Ginseng and Herb Research Institute, Guemsan 312 804, Korea
    J Ginseng Res 35:209-18. 2011
    ..the effects of crude gintonin from ginseng root, stem, and leaf on endogenous Ca(2+)-activated Cl- channel (CaCC) activity of Xenopus oocytes through mobilization of [Ca(2+)]i...
  85. doi Ca2+-activated Cl- channels
    Loretta Ferrera
    Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy
    Compr Physiol 1:2155-74. 2011
    ..In epithelial cells, CaCC activity mediates the secretion of Cl(-) and of other anions, such as bicarbonate and thiocyanate...
  86. pmc Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonist
    Wan Namkung
    College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406 840, Korea
    Mol Pharmacol 84:384-92. 2013
    ..synthetic small molecules revealed an amino-carbonitrile-pyrazole, C(act)-A1, that activated CFTR but not CaCC Cl⁻ conductance...
  87. doi The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels
    Paolo Scudieri
    Laboratory of Molecular Genetics, Istituto Giannina Gaslini, 16147 Genova, Italy
    Exp Physiol 97:177-83. 2012
    ..A close paralogue of TMEM16A, TMEM16B (anoctamin-2), is also associated with CaCC activity, although with different properties...
  88. doi Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation
    Juraj Rievaj
    Pulmonary Research Group, Department of Medicine, University of Alberta, 550 Heritage Medical Research Center, Edmonton, Alberta, Canada
    Pflugers Arch 463:497-509. 2012
    ..inhibitor indomethacin and largely blocked (>80%) by niflumic acid, a calcium-activated chloride channels' (CaCC) blocker. Allergic mice also showed an enhanced response to ATP and thapsigargin...
  89. pmc Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivity
    Hui Sun
    Division of Pulmonary and Critical Care Medicine, 5501, Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Physiol 590:3507-21. 2012
    ..The Ca(2+)-activated Cl(-) channel (CaCC), recently identified as TMEM16A, plays important roles in pulmonary vascular function...
  90. doi δ-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channels
    Daniela da Fonseca Pacheco
    Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais School of Biological Sciences and Health, University Center Newton Paiva, Belo Horizonte, Brazil
    J Pharm Pharmacol 64:1084-9. 2012
    ..The aim of this study was to determine whether Ca(2+)-activated Cl(-) channels (CaCCs) are involved in central antinociception induced by the activation of µ-, δ- and κ-opioid receptors...
  91. pmc Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction
    Fen Huang
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:16354-9. 2012
    ..Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...
  92. ncbi Structure and expression of a smooth muscle cell-specific gene, SM22 alpha
    J Solway
    Department of Medicine, University of Chicago, Illinois 60637, USA
    J Biol Chem 270:13460-9. 1995
    ..DNA sequence analyses revealed that the 441-base pair promoter contains two CArG/SRF boxes, a CACC box, and one potential MEF-2 binding site, cis-acting elements which are each important regulators of striated ..
  93. ncbi Localization and characterization of the mouse alpha-globin locus control region
    M F Kielman
    Department of Human Genetics, Leiden University, The Netherlands
    Genomics 21:431-3. 1994
    ..However, three of four CACC boxes and one GATA-1 binding site, identified in the human alpha-LCR, are not conserved in the mouse...
  94. ncbi Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene
    M Watanabe
    The Third Department of Internal Medicine, University of Tokyo, Japan
    Circ Res 78:978-89. 1996
    ..Double-stranded oligonucleotides containing either the CACC box or the Sp1 consensus sequence efficiently competed with the CCTCCC elements for binding the nuclear extracts...
  95. ncbi Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes
    P Hermand
    INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Blood 87:2962-7. 1996
    ..The 5'UT region (nucleotides -289 to +9) includes potential binding sites for various transcription factors (Ets, CACC, SP1, GATA-1, AP2) and exhibited a significant transcriptional activity after transfection in the erythroleukemic ..
  96. ncbi Kinetic and pharmacological properties of the calcium-activated chloride-current in macrovascular endothelial cells
    B Nilius
    Laboratorium voor Fysiologie, KU Leuven, Belgium
    Cell Calcium 22:53-63. 1997
    ..RT-PCR experiments did not provide any evidence that the endothelial Ca(2+)-activated Cl- channel might be identical with a recently cloned Ca(2+)-sensitive Cl- channel (CaCC).
  97. pmc Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region
    R Tewari
    Sars International Centre for Molecular Marine Biology, Bergen High Technology Centre, Thormohlensgt 55, N 5020 Bergen, Norway
    EMBO J 17:2334-41. 1998
    ..Thus, EKLF is thought to be a stage-specific factor acting through the CACC box in the beta-gene promoter, even though it is already present in embryonic red cells...
  98. ncbi Characterization of a murine gene homologous to the bovine CaCC chloride channel
    L Romio
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genoa 16148, Italy
    Gene 228:181-8. 1999
    The bovine CaCC protein is a putative Ca2+-dependent Cl- channel of airway epithelial cells. Therefore, CaCC proteins could contribute to transepithelial Cl- transport and accordingly modify the phenotype of cystic fibrosis (CF) patients...
  99. ncbi RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoter
    L G Tillotson
    Division of Digestive Diseases and Nutrition, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:8123-8. 1999
    ..Previous studies have shown that a CACC cis-regulatory element is important for transcriptional activation in pancreatic insulinoma cells...
  100. ncbi The CACC box and myocyte enhancer factor-2 sites within the myosin light chain 2 slow promoter cooperate in regulating nerve-specific transcription in skeletal muscle
    K Esser
    School of Kinesiology, University of Illinois at Chicago, Illinois 60608, USA
    J Biol Chem 274:12095-102. 1999
    ..Three sites within the proximal promoter (myocyte enhancer factor-2 (MEF2), E-box, and CACC box) were individually mutated, and the effect on luciferase expression was determined...
  101. ncbi CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1
    V Nedelcheva Kristensen
    Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
    Cancer Res 59:2825-8. 1999
    ..within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies...

Research Grants27

  1. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    ..potent and specific small molecule chemical probes for TMEM16A that encodes the calcium-activated chloride channel (CaCC)...
  2. Development of inhibitors of the calcium-activated chloride channel TMEM16a
    Marc O Anderson; Fiscal Year: 2013
    ..SAR of the modular 2-amino-4-arylthiazole scaffold for its efficacy to inhibit the TMEM16A, the first characterized CaCC. The central hypotheses of this proposal are: (a) the molecular structure of the 2-amino-4-arylthiazoles can be ..
  3. Lily Y Jan; Fiscal Year: 2016
    ..For example, CaCC contributes to signal amplification of sensory inputs and regulation of excitability of both sensory and central ..
  4. TMEM16A Channel Stoichiometry and Subunit Interaction
    Jason Tien; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The calcium-activated chloride channel (CaCC) was first observed in salamander retina in the early 1980s and has since then been found to be responsible for diverse phenomena ranging from signal ..
  5. Renzhi Han; Fiscal Year: 2016
    ..ten proteins all possessing eight transmembrane domains with proved or putative calcium-activated chloride channel (CaCC) functions. Mutations in the ANO5 gene (encoding Ano5) lead to muscular dystrophies in human patients...
  6. Investigating the neuronal physiology of TMEM16A Ca++ activated Cl- channels
    JAMES BERG; Fiscal Year: 2012
    ..in dorsal root ganglion (DRG) neurons where (due to high intracellular chloride concentration), the nature of CaCC opening is excitatory...
  7. THOMAS JOHN BRETT; Fiscal Year: 2016
    ..Finally, we will address the functional role of CLCA1 features in CaCC activation and the role of the channel in mucous cell metaplasia...
  8. H Criss Hartzell; Fiscal Year: 2016
    ..It is well-established that hBest1 encodes a Ca-activated chloride channel (CaCC) that is expressed in the basolateral membrane of the retinal pigment epithelium (RPE) and that bestrophinopathies ..
  9. Thomas L Pallone; Fiscal Year: 2014
    ..In turn, depolarization occurs through a combination of Ca2+ dependent Cl- channel (CaCC) activation and K+ channel inhibition...
  10. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012
    ..be examined: 1) dorsolateral prefrontal cortex (DLPFC);2) Rostral;and 3) Caudal anterior cingulate cortex (rACC and cACC);as well as 4) a control region the primary visual cortex (PVC)...
  11. BESTROPHIN AND RETINAL DISEASE
    Alan Marmorstein; Fiscal Year: 2009
    ..This led to the hypothesis that Best1 is a Ca2+ activated Cl- channel (CaCC) that generates the LP, and that BVMD results from loss of Best1 CaCC activity...
  12. BYPASSING THE SECRETORY DEFECT IN CYSTIC FIBROSIS
    Kim Barrett; Fiscal Year: 2000
    ..for chloride transport mediated by increases in intracellular calcium and a calcium-activated chloride channel (CaCC). However, both the cAMP and calcium-mediated pathways are defective in the intestines...
  13. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..the transcription factor Sox-2; an octamer binding motif, which binds the transcription factor Oct-3; and a GT/CACC box, which binds the transcription factors Spi and Sp3...
  14. NEURAL AND MECHANICAL REGULATION OF SLOW MYOSIN
    Karyn Esser; Fiscal Year: 2004
    ..Further analyses have identified that the CACC and MEF2 sites within this 270 bp region cooperate in regulating transcription in response to slow innervation...
  15. Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS Study
    Ruth Salo; Fiscal Year: 2007
    ..via MRS within Dorsolateral Prefrontal White Matter [WM], Rostral and Caudal Anterior Cingulate Cortex [rACC and cACC] as well as a control region the mesial occipital cortex...
  16. REGULATION OF CHLORIDE ION CONDUCTANCE IN PANCREAS DUCT
    Calvin Cotton; Fiscal Year: 2002
    ..The rationale for this approach rests upon the observation that Ca2+-activated C1-conductance (CACC) is preserved in human CF airway epithelia and that organ-specific disease severity in the CF knockout mouse is ..
  17. Acupuncture/Functional Imaging of the Brain
    Zang Hee Cho; Fiscal Year: 2002
    ....
  18. Ion Transport and Mucus Clearance in CF Airways
    Robert Tarran; Fiscal Year: 2007
    ..Based on these observations, the specific aims of this proposal are (1) to identify sensors of ASL volume, (2) to understand how ASL volume regulation is transduced and (3) to normalize CF airway surface liquid volume regulation. ..
  19. RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATER
    James Schafer; Fiscal Year: 2002
    ..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
  20. Matrix Metalloproteinases, Exercise, and Muscle Damage
    David Allen; Fiscal Year: 2008
    ..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
  21. The Human PFC Response to Drug Cues: Outcome Representation vs. Cognitive Contro
    Stefan Ursu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. TRAINING IN MOLECULAR AND CELL BIOLOGY OF CANCER
    BENDICHT PAULI; Fiscal Year: 2007
    ..Specialized support facilities are provided by the Cornell Biotechnology Program, computer facilities, center for research animal resources (including mouse transgenic facilities), and library system. [unreadable] [unreadable]..
  23. 3D Imaging of electrical activity in myocardial tissue
    Arkady Pertsov; Fiscal Year: 2007
    ..Successful completion of this project will break ground for a new technology, the 3D imaging of electrical activation in the heart. ..
  24. Study of Tritonia crawl circuit and ciliated motor cells
    OWEN WOODWARD; Fiscal Year: 2005
    ..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..
  25. A New Method for Retinal Imaging
    Alan Marmorstein; Fiscal Year: 2005
    ..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..
  26. Chloride Signaling
    H Hartzell; Fiscal Year: 2003
    ..in the roles of chloride in membrane trafficking, neuroscientists interested in the signaling of chloride channels, transport physiologists involved in ion homeostasis, and geneticists interested in channelopathies ..
  27. ORGAN-SPECIFIC VASCULAR ARREST OF MALIGNANT CELLS
    BENDICHT PAULI; Fiscal Year: 2002
    ..Understanding the molecular principles that govern extravasation will ultimately allow us to develop strategies in anti-metastatic therapies. ..