Genomes and Genes
Gene Symbol: CLCA4
Description: chloride channel accessory 4
Alias: CaCC, CaCC2, calcium-activated chloride channel regulator 4, caCC-2, calcium-activated chloride channel family member 4, calcium-activated chloride channel protein 2, chloride channel regulator 4, chloride channel, calcium activated, family member 4, hCLCA4, hCaCC-2
Publications154 found, 100 shown here
- HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulationQ H Liu
Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 97:4832-7. 2000..Intracellular signaling responses of macrophages to HIV-1 may modulate postentry steps of infection and cell functions apart from infection...
- Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and tracheaM Agnel
Synthelabo Recherche, Genomic Biology Department, Rueil Malmaison, France
FEBS Lett 455:295-301. 1999..Another original feature as compared to the CaCC family members is the fact that hCaCC-2 also shows expression in the brain...
- The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosisMargit Ritzka
Department of Pediatrics and Clinical CF Research Group, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
Hum Genet 115:483-91. 2004..Transmission disequilibrium and the significance of the association decreased within the locus from hCLCA2 towards hCLCA4. Expression of hCLCA1 and hCLCA4 in human rectal mucosa was proven by microarray analysis...
- CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestineErnst Wolfgang Kolbe
Department of Pediatrics, Hannover Medical School, Hannover, Germany
Eur J Hum Genet 21:691-4. 2013..The manifestation of the basic defect was associated with markers rs11807298-rs6684219, encompassing the CLCA4 promoter (Praw=0.0013; Pcorr=0.0157)...
- Increased hyperalgesia by 5-nitro-2, 3-(phenylpropylamino)-benzoic acid (NPPB), a chloride channel blocker in crush injury-induced neuropathic pain in ratsVinod D Ramteke
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute Izatnagar, Bareilly, U P, 243 122, India
Pharmacol Biochem Behav 91:417-22. 2009..injury-induced neuropathic pain in rats by using ivermectin, a ligand gated chloride channel opener and NPPB, a CaCC blocker. The effect of ivermectin (5, 10, 20 mg/kg i.p. or 50, 100 and 200 microg/rat by i.c.v...
- Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colonKuai Yu
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Clin Invest 120:1722-35. 2010..Here we investigated the role of a candidate CaCC protein, bestrophin-2 (Best2), using Best2-/- mice...
- House dust mite extract activates apical Cl(-) channels through protease-activated receptor 2 in human airway epitheliaHyung Ju Cho
Department of Otorhinolaryngology, Hallym University College of Medicine, Seoul, South Korea
J Cell Biochem 109:1254-63. 2010..both a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and a Ca(2+)-activated Cl(-) channel (CaCC) inhibitor. HDM extract also stimulated fluid secretion from porcine airway mucosa...
- A high-throughput data mining of single nucleotide polymorphisms in Coffea species expressed sequence tags suggests differential homeologous gene expression in the allotetraploid Coffea arabicaRamon Oliveira Vidal
Laboratório de Genômica e Expressão, Departamento de Genetica, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, CEP 13083 970, Campinas SP, Brazil
Plant Physiol 154:1053-66. 2010..The assignment of the C. arabica haplotypes to the C. canephora (CaCc) or C...
- Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channelRicardo de la Fuente
1246 Health Sciences East Tower, Box 0521, University of California, San Francisco CA 94143 0521, USA
Mol Pharmacol 73:758-68. 2008..Potent, selective CaCC inhibitors have not been available...
- Microdialysates of amines and metabolites from core nucleus accumbens of freely moving rats are altered by dizocilpineI Hatip-Al-Khatib
Department of Pharmacology, Faculty of Medicine, Pamukkale University, P O Box 33, 20027, Denizli, Turkey
Brain Res 902:108-18. 2001..585+/-0.01 fmol/microl), low 5-HT (0.334+/-0.032 fmol/microl) and high DOPAC/DA ratio (265.11+/-20.73) in intact cACC. 6-OHDA alone (8 microg/2 microl) depleted DA (-66%), DOPAC (-65%), and NE (-62%)...
- Dynamic sorption of ionizable organic compounds (IOCs) and xylene from water using geomaterial-modified montmorilloniteM Houari
Departement of Chemical Engineering, University of Blida, P O Box 270 09000 Blida, Algeria
J Hazard Mater 147:738-45. 2007..and fixed-bed column studies were undertaken to evaluate the performance of clay-active coal-coated cement (CACC) in removing phenols from aqueous solution...
- Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guidelineJohn W Funder
Prince Henry s Institute of Medical Research, Clayton, Vic, Australia
J Clin Endocrinol Metab 93:3266-81. 2008..Our objective was to develop clinical practice guidelines for the diagnosis and treatment of patients with primary aldosteronism...
- In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reactionE C Strauss
Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
Mol Cell Biol 12:2135-42. 1992..on chromosome 16 in a mouse erythroleukemia cell environment revealed protein occupancy at GATA-1, AP-1/NF-E2, and CACC/GGTGG motifs, specific differences compared with in vitro protein binding, and distinct changes in one region upon ..
- Structure of the L-histidine decarboxylase geneK Yatsunami
Japan Tobacco Inc, Pharmaceutical Basic Research Laboratories, Yokohama
J Biol Chem 269:1554-9. 1994..We found a TATA-like sequence, a GC box, four CACC boxes, four GATA consensus sequences, and six leader-binding protein-1 binding motifs in the promoter region of the ..
- Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green teaWan Namkung
Department of Medicine, University of California, San Francisco, CA 94143 0521, USA
FASEB J 24:4178-86. 2010TMEM16A was found recently to be a calcium-activated Cl(-) channel (CaCC)...
- Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channelsW R Sones
Division of Basic Medical Sciences, St George s, University of London, London, UK
Br J Pharmacol 158:521-31. 2009..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
- Chloride transport in NCL-SG3 sweat gland cells: channels involvedZ Servetnyk
Department of Medical Cell Biology, Uppsala University, Box 571, SE 751 23 Uppsala, Sweden
Exp Mol Pathol 83:47-53. 2007..Ca(2+)-activated chloride conductance is confirmed and the putative Ca(2+)-activated chloride channel (CaCC) is further characterized in term of its pharmacological sensitivity...
- Identification of novel, cardiac-restricted transcription factors binding to a CACC-box within the human cardiac troponin I promoterK A Dellow
Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, Dovehouse Street, London SW3 6LY, UK
Cardiovasc Res 50:24-33. 2001..In analysing the putative binding elements within the proximal promoter, a CACC-box sequence overlapping a consensus Sp1 element has been identified...
- Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: a behavioral and in vivo microdialysis studyI Hatip-Al-khati
Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
Jpn J Pharmacol 87:277-87. 2001..and extracellular amines concentration by 6-hydroxydopamine (6-OHDA)-induced lesion of core nucleus accumbens (cACC) of rats...
- The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expressionC M Li
Department of Human Genetics, Mount Sinai School of Medicine, New York 10029, USA
Genomics 62:223-31. 1999..several sequences matching transcription factor binding sites, including nine SP-1 sites, one AP-1 site, and three CACC boxes...
- The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesisD Treichel
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077, Gottingen, Germany
Mech Dev 101:175-9. 2001..characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the promoter of many genes...
- Pain dynamics observed by functional magnetic resonance imaging: differential regression analysis techniqueZang Hee Cho
Department of Radiological Sciences, University of California, Irvine, California 92697, USA
J Magn Reson Imaging 18:273-83. 2003..To observe the dynamic responses of the cortical areas related to the pain processing by using the differential regression analysis (DRA) technique in functional magnetic resonance imaging (fMRI) and investigation of pain mechanisms...
- Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airwaysJason R Rock
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27708, USA
J Biol Chem 284:14875-80. 2009..CaCCs) play a role in airway epithelial Cl(-) secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC...
- Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal musclesSung Jin Hwang
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
J Physiol 587:4887-904. 2009..Several conductances, such as Ca(2+)-activated Cl() channels (CaCC) and non-selective cation channels (NSCC) have been suggested to be involved in slow wave depolarization...
- Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cellsVictor G Romanenko
Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 285:12990-3001. 2010Activation of an apical Ca(2+)-dependent Cl(-) channel (CaCC) is the rate-limiting step for fluid secretion in many exocrine tissues...
- Environmental factors promoting the effective use of a computer-assisted clinical case for second-year osteopathic medical studentsR W Baer
Department of Physiology, Kirksville College of Osteopathic Medicine, USA
J Am Osteopath Assoc 98:380-5. 1998Computer-aided clinical cases (CACC) have the potential to complement and/or supplement other types of problem-based learning exercises in modern medical curricula...
- Effect of NYD-SP27 down-regulation on ATP-induced Ca2+-dependent pancreatic duct anion secretion in cystic fibrosis cellsJin Xia Zhu
Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, Rm 410, Basic Medical Science Building, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Cell Biol Int 31:521-5. 2007..The inhibitor of adenylate cyclase, MDL12330A (20 microM), and Ca(2+)-dependent Cl(-) channel (CaCC) blocker, DIDS (100 microM) also significantly reduced the basal current in AT-CF...
- Cloning and characterization of a calcium-activated chloride channel in rat uterusJunfang Song
Institute of Genetics and Developmental Biology and State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Biol Reprod 80:788-94. 2009..in regulation of uterine contractility, we cloned a novel calcium-activated chloride channel gene, named rat Clca4, from pregnant rat uterus...
- Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) geneJ F Medina
Department of Medicine, University Clinic and Medical School, University of Navarra, Pamplona, Spain
Genomics 39:74-85. 1997..These features, as well as the presence of several consensus elements such as GATA, LBP-1, E-box, CACC box, and T-antigen motif, indicate that the human AE2 promoter resembles the erythroid promoter of the human AE1 ..
- Expression and biological significance of Ca2+-activated ion channels in human keratinocytesH Koegel
Department of Physiology, University of Munich, D 80336 Munich, Germany
FASEB J 15:145-154. 2001..data, RT-PCR showed that HaCaT keratinocytes express two types of Ca2+-activated Cl- channels, CaCC2 and CaCC3 (CLCA2), as well as the Ca2+-activated K+ channel hSK4...
- EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2Michael R Tallack
Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Australia
J Biol Chem 284:20966-74. 2009..We found and validated novel intronic enhancers in both the E2f2 and E2f4 genes, which contain conserved CACC, GATA, and E-BOX elements. The E2f2 enhancer was occupied by EKLF in vivo...
- Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colonN S Nanda Kumar
Depts of Biochemistry and Microbiology, West Virginia Univ School of Medicine, Morgantown, 26506, USA
Am J Physiol Gastrointest Liver Physiol 299:G707-14. 2010..acid, whereas it was only partially inhibited by CFTR [CFTR(inh)-172, glibenclamide]- and CaCC (niflumic acid)-specific Cl(-) channel blockers...
- myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell lineM A Carew
Inositide Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 275:26906-13. 2000Does inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P(4)) inhibit apical Ca(2+)-activated Cl(-) conductance (CaCC)? We studied this question using human CFPAC-1 pancreatoma cells grown in polarized monolayers...
- Polarized signaling via purinoceptors in normal and cystic fibrosis airway epitheliaA M Paradiso
Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Gen Physiol 117:53-67. 2001..response was mediated exclusively via Ca(2+)(i) interacting with a Ca(2+)-activated Cl(-) channel (CaCC)...
- Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airwayLihua Liang
Department of Physiology, Johns Hopkins University School of Medicine, 725 N Wolfe St, Baltimore, MD 21205, USA
Am J Physiol Cell Physiol 296:C131-41. 2009..developed a screening assay and screened a library for compounds that could enhance cytoplasmic Ca2+, activate the CaCC, and increase Cl(-) secretion...
- Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cellsFadi Aldehni
Department of Physiology, University of Regensburg, University Street 31, Regensburg 93053, Germany
J Am Soc Nephrol 20:1556-64. 2009..ii) a loss of amiloride-sensitive Na(+) absorption, iii) induction of Ca(2+)-dependent Cl(-) conductance (CaCC), and iv) epithelial-to-mesenchymal transition...
- Biomarkers of human gastrointestinal tract regionsElena Maria Comelli
Department of Nutrition and Health, Nestle Research Center, Vers chez les Blanc, Lausanne, Switzerland
Mamm Genome 20:516-27. 2009..These include CLCA4 and SLC26A2, both implicated in ion transport...
- TMEM16 proteins: the long awaited calcium-activated chloride channels?C A Flores
Centro de Estudios Cientificos CECS, Valdivia, Chile
Braz J Med Biol Res 42:993-1001. 2009..by three independent groups, using different strategies, of TMEM16A as the molecular counterpart of the CaCC is discussed. TMEM16A is part of a family that has 10 other members in mice...
- Vaccine against MUC1 antigen expressed in inflammatory bowel disease and cancer lessens colonic inflammation and prevents progression to colitis-associated colon cancerPamela L Beatty
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Cancer Prev Res (Phila) 3:438-46. 2010..in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC)...
- Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16AJohn T Sheridan
Department of Cell and Molecular Physiology, University of North Carolina, North Carolina, Chapel Hill 27599, USA
J Biol Chem 286:1381-8. 2011..Ano)/TMEM16A family have recently been identified as essential subunits of the Ca(2+)-activated chloride channel (CaCC)...
- Presence of the Ca2+-activated chloride channel anoctamin 1 in the urethra and its role in excitatory neurotransmissionMaria Sancho
Dept of Physiology, Veterinary School, Madrid, Spain
Am J Physiol Renal Physiol 302:F390-400. 2012We investigated the cellular distribution of the calcium-activated chloride channel (CaCC), anoctamin 1, in the urethra of mice, rats, and sheep by both immunofluorescence and PCR...
- Calcium-activated chloride current expression in axotomized sensory neurons: what for?Mathieu Boudes
INSERM U 1051, Sensory Diseases, Neuro plasticity and Therapy, Institut des Neurosciences de Montpellier Montpellier, France
Front Mol Neurosci 5:35. 2012..Functional screenings of potential candidate genes established that Best1 is a molecular determinant for CaCC expression among axotomized sensory neurons, while Tmem16a is acutely activated by inflammatory mediators in ..
- Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin networkPatricia Perez-Cornejo
Physiology Department, School of Medicine, Universidad Autonoma de San Luis Potosi, San Luis Potosi, SLP 78210, Mexico
Proc Natl Acad Sci U S A 109:10376-81. 2012The newly discovered Ca(2+)-activated Cl(-) channel (CaCC), Anoctamin 1 (Ano1 or TMEM16A), has been implicated in vital physiological functions including epithelial fluid secretion, gut motility, and smooth muscle tone...
- Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinomaWen Liu
Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, China
Cancer Lett 326:41-51. 2012..ANO1/TMEM16A was recently identified as a CaCC, and it is of interest to determine whether ANO1 plays a role in development and metastasis of prostate carcinoma...
- Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasiaPaolo Scudieri
Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy
J Physiol 590:6141-55. 2012The TMEM16A protein has a potential role as a Ca(2+)-activated Cl(-) channel (CaCC) in airway epithelia where it may be important in the homeostasis of the airway surface fluid...
- Functional coupling of TRPC2 cation channels and the calcium-activated anion channels in rat thyroid cells: implications for iodide homeostasisTero M Viitanen
Department of Biosciences, Abo Akademi University, Turku, Finland
J Cell Physiol 228:814-23. 2013..Our whole-cell voltage clamp recordings revealed the presence of a Ca(2+) activated Cl(-) current (CaCC) in Fisher rat thyroid cell line 5 (FRTL-5)...
- GPR39 is coupled to TMEM16A in intestinal fibroblast-like cellsFanning Zeng
Gastrointestinal Disease Area, Novartis Horsham Research Centre, Horsham, United Kingdom
PLoS ONE 7:e47686. 2012..This Zn(2+)-induced current could be suppressed by application of a TMEM16A antagonist, CaCC(inh)-A01, or by silencing Tmem16a expression...
- Purinergic regulation of CFTR and Ca(2+)-activated Cl(-) channels and K(+) channels in human pancreatic duct epitheliumJing Wang
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Cell Physiol 304:C673-84. 2013..Apically applied ATP/UTP stimulated CF transmembrane conductance regulator (CFTR) and Ca(2+)-activated Cl(-) (CaCC) channels, which were inhibited by CFTRinh-172 and niflumic acid, respectively...
- Computed tomography and echocardiography together reveal more high-risk findings than echocardiography alone in the diagnostics of stroke etiologyPetri Sipola
Department of Clinical Radiology, Diagnostic Imaging Centre, Neuro Center, Kuopio University Hospital, Kuopio, Finland
Cerebrovasc Dis 35:521-30. 2013..We investigate whether combined examination of the heart, aorta, and cervicocranial arteries with computed tomography (CACC-CT) may improve the diagnosis of stroke etiology.
- Chloride channel-targeted therapy for secretory diarrheasJay R Thiagarajah
Departments of Medicine and Physiology, University of California, San Francisco, CA 94143 0521, USA Division of Gastroenterology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Curr Opin Pharmacol 13:888-94. 2013..High-throughput screens have yielded several chemical classes of small molecule CFTR and CaCC inhibitors that show efficacy in animal models of diarrheas...
- MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1Soo Jin Oh
Center for Neuroscience and Center for Functional Connectomics, Brain Science Institute S J O, J J, J K, J Y C, C J L, and Chemical Kinomics Research Center, Future Convergence Research Division S J H, E J R, Korea Institute of Science and Technology KIST, Seoul, Korea Neuroscience Program, University of Science and Technology, Daejeon, Korea C J L KU KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Korea C J L and Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia K Y, H C H
Mol Pharmacol 84:726-35. 2013..widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions...
- Mas-related G protein-coupled receptor D is coupled to endogenous calcium-activated chloride channel in Xenopus oocytesRen Gong Zhuo
Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
J Physiol Biochem 70:185-91. 2014..However, protein kinase C inhibitor did not display any visible effect on CaCC currents...
- Activation and inhibition of TMEM16A calcium-activated chloride channelsYu Li Ni
Department of Neurology, Center for Neuroscience, University of California Davis, Davis, California, United States of America
PLoS ONE 9:e86734. 2014Calcium-activated chloride channels (CaCC) encoded by family members of transmembrane proteins of unknown function 16 (TMEM16) have recently been intensely studied for functional properties as well as their physiological roles as chloride ..
- Modulation of TMEM16A-channel activity as Ca²⁺ activated Cl⁻ conductance via the interaction with actin cytoskeleton in murine portal veinJunya Ohshiro
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
J Pharmacol Sci 125:107-11. 2014TMEM16A is a major component of Ca(2+)-activated Cl(-) channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs...
- Functional role of the Ca²⁺-activated Cl⁻ channel DOG1/TMEM16A in gastrointestinal stromal tumor cellsErik Berglund
Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm, Sweden Electronic address
Exp Cell Res 326:315-25. 2014DOG1, a Ca(2+)-activated Cl(-) channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST)...
- Characterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced ArrhythmiasZhen Ye
Departments of Clinical Pharmacy and Cardiology, The 2nd Affiliated Hospital, Harbin Medical University, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin, P R China
J Cell Physiol 230:337-46. 2015Anoctamin1 (ANO1) encodes a Ca(2+)-activated chloride (Cl(-)) channel (CaCC) in variety tissues of many species. Whether ANO1 expresses and functions as a CaCC in cardiomyocytes remain unknown...
- Evidence for the participation of Ca(2+)-activated chloride channels in formalin-induced acute and chronic nociceptionGuadalupe Garcia
Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Cinvestav, Sede Sur México, D F, Mexico
Brain Res 1579:35-44. 2014In this study we determined the role of Ca(2+)-activated chloride channels (CaCC) in acute and chronic nociceptive responses elicited by 1% formalin. Formalin injection produced a typical pattern of flinching behavior for about 1h...
- In silico determination of the effect of multi-target drugs on calcium dynamics signaling network underlying sea urchin spermatozoa motilityJesús Espinal-Enríquez
Instituto de Ciencias Fisicas, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, México Centro de Ciencias de la Complejidad, Ciudad Universitaria, Mexico, México Instituto Nacional de Medicina Genómica, Arenal Tepepan, Tlalpan, Mexico
PLoS ONE 9:e104451. 2014..NFA are: hyperpolarization-activated and cyclic nucleotide gated Na+ channels (HCN), [Ca2+]-dependent Cl- channels (CaCC) and [Ca2+]-dependent K+ channels (CaKC), all present in the sea urchin genome...
- Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cellsYujie Sui
Key Laboratory for Molecular and Chemical Genetics of Critical Human Diseases of Jilin Province, Jilin University Bethune Second Hospital, Changchun, P R China
PLoS ONE 9:e115443. 2014..TMEM16A (ANO1, DOG1 or TAOS2) has recently been identified as a calcium-activated chloride channel (CaCC) and is reported to be overexpressed in several malignancies; however, its expression and function in colorectal ..
- A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary glandMarcelo A Catalán
Secretory Mechanisms and Dysfunction Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892
Proc Natl Acad Sci U S A 112:2263-8. 2015Activation of an apical Ca(2+)-activated Cl(-) channel (CaCC) triggers the secretion of saliva...
- TRPC1 regulates calcium-activated chloride channels in salivary gland cellsYuyang Sun
Department of Basic Sciences, School of Medicine Health Sciences, University of North Dakota, Grand Forks, North Dakota
J Cell Physiol 230:2848-56. 2015Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion...
- Uterine Contractility in the Nonpregnant Mouse: Changes During the Estrous Cycle and Effects of Chloride Channel BlockadeKelsi N Dodds
Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
Biol Reprod 92:141. 2015..It is unlikely that this conductance is generated by the Ca(2+)-activated Cl(-) channels, anoctamin-1 and CLCA4, as immunohistochemical labeling did not reveal protein expression within muscle or pacemaker cell networks...
- Inhibition of intestinal chloride secretion by piperine as a cellular basis for the anti-secretory effect of black peppersPawin Pongkorpsakol
Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Ratchathewee, Bangkok, Thailand
Pharmacol Res 100:271-80. 2015..Piperine suppressed Ca2+-activated Cl- channels (CaCC) without affecting intracellular Ca2+ concentrations or Ca2+-activated basolateral K+ channels...
- Deciphering the regulon of a GntR family regulator via transcriptome and ChIP-exo analyses and its contribution to virulence in Xanthomonas citriXiaofeng Zhou
Citrus Research and Education Center, Department of Microbiology and Cell Science, IFAS, University of Florida, 700 Experiment Station Road, Lake Alfred, FL, 33850, USA
Mol Plant Pathol 18:249-262. 2017..analysis revealed that YtrA directly regulates three operons by binding to a palindromic motif GGTG-N16 -CACC at the promoter region...
- Surface expression of the Anoctamin-1 (ANO1) channel is suppressed by protein-protein interactions with β-COPYoung Sun Lee
School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul 02841, Republic of Korea Center for Functional Connectomics, Korea Institute of Science and Technology KIST, Seoul 02792, Republic of Korea
Biochem Biophys Res Commun 475:216-22. 2016Anoctamin-1 (ANO1) is a Ca(2+)-activated chloride channel (CaCC) that plays important physiological roles in normal and cancerous tissues. However, the plasma membrane trafficking mechanisms of ANO1 remain poorly characterized...
- Coupling of TRPV6 and TMEM16A in epithelial principal cells of the rat epididymisDa Yuan Gao
School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
J Gen Physiol 148:161-82. 2016..and pharmacological data also reveal a constitutively active calcium-activated chloride conductance (CaCC). Removal of extracellular calcium attenuates not only the TRPV6-like conductance, but also the CaCC...
- Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channelsIsabella Salzer
Centre for Physiology and Pharmacology, Medical University of Vienna, Waehringerstrasse 13a, A 1090 Vienna, Austria
Neuropharmacology 110:277-86. 2016..5HT2C receptor blocker only, and the current was prevented by an inhibitor of Ca(2+)-activated chloride channels (CaCC)...
- Ca2+-activated Cl- channel currents in mammary secretory cells from lactating mouseAkihiro Kamikawa
Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan and
Am J Physiol Cell Physiol 311:C808-C819. 2016The Cl- secretion via Ca2+-activated Cl- channel (CaCC) is critical for fluid secretion in exocrine glands like the salivary gland...
- Evaluation of the impacts of cooperative adaptive cruise control on reducing rear-end collision risks on freewaysYe Li
School of Transportation, Southeast University, 2 Si Pai Lou, Nanjing, 210096, PR China Electronic address
Accid Anal Prev 98:87-95. 2017Although plenty of studies have been conducted recently about the impacts of cooperative adaptive cruise control (CACC) system on traffic efficiency, there are few researches analyzing the safety effects of this advanced driving-assistant ..
- Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of CajalMei Hong Zhu
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada
Am J Physiol Gastrointest Liver Physiol 311:G1037-G1046. 2016..electrical slow waves by coordinated openings of ANO1 channels, a Ca2+-activated Cl- (CaCC) conductance...
- Extracellular protons enable activation of the calcium-dependent chloride channel TMEM16ASilvia Cruz-Rangel
Physics Institute, Universidad Autonoma de San Luis Potosi, Ave Dr Manuel Nava 6, San Luis Potosi, SLP, 78290, Mexico
J Physiol . 2016..These findings are critical for understanding physiological and pathological processes that involve changes in pH and chloride flux via TMEM16A...
- Role of Quercetin in Modulating Chloride Transport in the IntestineBo Yu
Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, School of Life Sciences, Liaoning Normal University Dalian, China
Front Physiol 7:549. 2016..In this study, we have identified a flavonoid quercetin as a modulator of CaCC chloride channel activity...
- Anoctamin2 (TMEM16B) forms the Ca2+-activated Cl- channel in the retinal pigment epitheliumSusanne Keckeis
Experimental Ophthalmology, Department of Ophthalmology, Charite University Medicine Berlin, Berlin, Germany
Exp Eye Res . 2016..Ca2+-dependent chloride channels (CaCC) in the RPE were found to adapt Cl- transport to specific needs by increasing intracellular free Ca..
- Regulation of epithelial ion transport in exocrine glands by store-operated Ca2+ entryAxel R Concepcion
Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA
Cell Calcium . 2016..an important, non-redundant role in regulating the function of Ca2+-activated Cl- channels (CaCC), Cl- secretion and sweat production...
- A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoterChang Yun Gui
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:7009-14. 2003..In contrast, promoter hyperacetylation requires the promoter GATA-1, and CACC-factor activator motifs, as well as the TATA box...
- SNPs at the APOA5 gene account for the strong association with hypertriglyceridaemia at the APOA5/A4/C3/A1 locus on chromosome 11q23 in the Northern Irish populationWilliam T Wright
Centre for Clinical and Population Science, Queen s University, Belfast BT9 7AB, UK
Atherosclerosis 185:353-60. 2006..102C > T, c.340C > G] using THESIAS has identified two major haplotypes relative to the most common CACC haplotype showing very strong association with hypertriglyceridaemia, CGTG and GATC (odds ratio 7.45 and 5.26)...
- Construction of pDESTR, a GATEWAY vector for gene disruption in filamentous fungiAyumi Abe
Laboratory of Applied Microbiology, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Sapporo, 060 8589, Japan
Curr Microbiol 52:210-5. 2006..After the amplification with a 5'CACC-tagged primer and an ordinary primer, the DNA fragment will be inserted into pENTR/D-TOPO vector and then ..
- TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming abilityTa To Tran
Department of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
J Cell Physiol 229:181-90. 2014..TMEM16E did not exhibit cell surface calcium-dependent chloride channel (CaCC) activity, which was originally identified in TMEM16A and TMEM16B, due to their intracellular vesicle distribution...
- Purified TMEM16A is sufficient to form Ca2+-activated Cl- channelsHiroyuki Terashima
Departments of Anesthesiology, Physiology and Biophysics, and Biochemistry, Weill Cornell Medical College, Cornell University, New York, NY 10065
Proc Natl Acad Sci U S A 110:19354-9. 2013..Well-characterized CaCC blockers inhibit Cl(-) transport with Kis comparable to those measured for native and heterologously expressed ..
- Specificity of mammalian Y-box binding protein p50 in interaction with ss and ds DNA analyzed with generic oligonucleotide microchipO A Zasedateleva
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov Street, 119991 Moscow, Russian Federation
J Mol Biol 324:73-87. 2002..The binding of p50 to the generic microchip was shown to be the most specific to ss GGGG motif and then to ss CACC and CATC motifs...
- Preliminary pharmacological characterisation of an interleukin-13-enhanced calcium-activated chloride conductance in the human airway epitheliumHazel Atherton
Novartis Respiratory Research Centre, Wimblehurst Road, Horsham, West Sussex, UK
Naunyn Schmiedebergs Arch Pharmacol 367:214-7. 2003..short circuit current (ISC) and the appearance of an enhanced calcium-activated chloride conductance (CaCC)...
- Role of Ca2+-activated Cl- channels in the mechanism of apoptosis induced by cyclosporin A in a human hepatoma cell lineJung Ae Kim
College of Pharmacy, Yeungnam University, Gyongsan 712 749, South Korea
Biochem Biophys Res Commun 309:291-7. 2003..Treatment with these CaCC inhibitors (NA, FA, NPPB, and DIDS) markedly prevented the CsA-induced apoptosis...
- Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscleGeorge Gallos
Dept of Anesthesiology, 622 W 168th St P and S Box 46, Columbia Univ College of Physicians and Surgeons, New York, NY 10032
Am J Physiol Lung Cell Mol Physiol 305:L625-34. 2013..Although calcium-activated chloride channel (CaCC) flux has been described in many cell types, including human airway smooth muscle (HASM), the true molecular ..
- A simple method for the preparation of crude gintonin from ginseng root, stem, and leafMi Kyung Pyo
International Ginseng and Herb Research Institute, Guemsan 312 804, Korea
J Ginseng Res 35:209-18. 2011..the effects of crude gintonin from ginseng root, stem, and leaf on endogenous Ca(2+)-activated Cl- channel (CaCC) activity of Xenopus oocytes through mobilization of [Ca(2+)]i...
- Ca2+-activated Cl- channelsLoretta Ferrera
Laboratory of Molecular Genetics, Istituto Giannina Gaslini, Genova, Italy
Compr Physiol 1:2155-74. 2011..In epithelial cells, CaCC activity mediates the secretion of Cl(-) and of other anions, such as bicarbonate and thiocyanate...
- Novel amino-carbonitrile-pyrazole identified in a small molecule screen activates wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator in the absence of a cAMP agonistWan Namkung
College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 406 840, Korea
Mol Pharmacol 84:384-92. 2013..synthetic small molecules revealed an amino-carbonitrile-pyrazole, C(act)-A1, that activated CFTR but not CaCC Cl⁻ conductance...
- The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channelsPaolo Scudieri
Laboratory of Molecular Genetics, Istituto Giannina Gaslini, 16147 Genova, Italy
Exp Physiol 97:177-83. 2012..A close paralogue of TMEM16A, TMEM16B (anoctamin-2), is also associated with CaCC activity, although with different properties...
- Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activationJuraj Rievaj
Pulmonary Research Group, Department of Medicine, University of Alberta, 550 Heritage Medical Research Center, Edmonton, Alberta, Canada
Pflugers Arch 463:497-509. 2012..inhibitor indomethacin and largely blocked (>80%) by niflumic acid, a calcium-activated chloride channels' (CaCC) blocker. Allergic mice also showed an enhanced response to ATP and thapsigargin...
- Chronic hypoxia-induced upregulation of Ca2+-activated Cl- channel in pulmonary arterial myocytes: a mechanism contributing to enhanced vasoreactivityHui Sun
Division of Pulmonary and Critical Care Medicine, 5501, Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Physiol 590:3507-21. 2012..The Ca(2+)-activated Cl(-) channel (CaCC), recently identified as TMEM16A, plays important roles in pulmonary vascular function...
- δ-Opioid receptor agonist SNC80 induces central antinociception mediated by Ca2+ -activated Cl- channelsDaniela da Fonseca Pacheco
Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais School of Biological Sciences and Health, University Center Newton Paiva, Belo Horizonte, Brazil
J Pharm Pharmacol 64:1084-9. 2012..The aim of this study was to determine whether Ca(2+)-activated Cl(-) channels (CaCCs) are involved in central antinociception induced by the activation of µ-, δ- and κ-opioid receptors...
- Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contractionFen Huang
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 109:16354-9. 2012..Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...
- Structure and expression of a smooth muscle cell-specific gene, SM22 alphaJ Solway
Department of Medicine, University of Chicago, Illinois 60637, USA
J Biol Chem 270:13460-9. 1995..DNA sequence analyses revealed that the 441-base pair promoter contains two CArG/SRF boxes, a CACC box, and one potential MEF-2 binding site, cis-acting elements which are each important regulators of striated ..
- Localization and characterization of the mouse alpha-globin locus control regionM F Kielman
Department of Human Genetics, Leiden University, The Netherlands
Genomics 21:431-3. 1994..However, three of four CACC boxes and one GATA-1 binding site, identified in the human alpha-LCR, are not conserved in the mouse...
- Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) geneM Watanabe
The Third Department of Internal Medicine, University of Tokyo, Japan
Circ Res 78:978-89. 1996..Double-stranded oligonucleotides containing either the CACC box or the Sp1 consensus sequence efficiently competed with the CCTCCC elements for binding the nuclear extracts...
- Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypesP Hermand
INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
Blood 87:2962-7. 1996..The 5'UT region (nucleotides -289 to +9) includes potential binding sites for various transcription factors (Ets, CACC, SP1, GATA-1, AP2) and exhibited a significant transcriptional activity after transfection in the erythroleukemic ..
- Kinetic and pharmacological properties of the calcium-activated chloride-current in macrovascular endothelial cellsB Nilius
Laboratorium voor Fysiologie, KU Leuven, Belgium
Cell Calcium 22:53-63. 1997..RT-PCR experiments did not provide any evidence that the endothelial Ca(2+)-activated Cl- channel might be identical with a recently cloned Ca(2+)-sensitive Cl- channel (CaCC).
- Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control regionR Tewari
Sars International Centre for Molecular Marine Biology, Bergen High Technology Centre, Thormohlensgt 55, N 5020 Bergen, Norway
EMBO J 17:2334-41. 1998..Thus, EKLF is thought to be a stage-specific factor acting through the CACC box in the beta-gene promoter, even though it is already present in embryonic red cells...
- Characterization of a murine gene homologous to the bovine CaCC chloride channelL Romio
Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, Genoa 16148, Italy
Gene 228:181-8. 1999The bovine CaCC protein is a putative Ca2+-dependent Cl- channel of airway epithelial cells. Therefore, CaCC proteins could contribute to transepithelial Cl- transport and accordingly modify the phenotype of cystic fibrosis (CF) patients...
- RIN ZF, a novel zinc finger gene, encodes proteins that bind to the CACC element of the gastrin promoterL G Tillotson
Division of Digestive Diseases and Nutrition, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 274:8123-8. 1999..Previous studies have shown that a CACC cis-regulatory element is important for transcriptional activation in pancreatic insulinoma cells...
- The CACC box and myocyte enhancer factor-2 sites within the myosin light chain 2 slow promoter cooperate in regulating nerve-specific transcription in skeletal muscleK Esser
School of Kinesiology, University of Illinois at Chicago, Illinois 60608, USA
J Biol Chem 274:12095-102. 1999..Three sites within the proximal promoter (myocyte enhancer factor-2 (MEF2), E-box, and CACC box) were individually mutated, and the effect on luciferase expression was determined...
- CYP17 and breast cancer risk: the polymorphism in the 5' flanking area of the gene does not influence binding to Sp-1V Nedelcheva Kristensen
Department of Genetics, Institute of Cancer Research, The Norwegian Radium Hospital, University Clinic, Oslo
Cancer Res 59:2825-8. 1999..within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies...
- Development of Bioactive Chemical Probes for Calcium-activated Chloride ChannelMin Li; Fiscal Year: 2012..potent and specific small molecule chemical probes for TMEM16A that encodes the calcium-activated chloride channel (CaCC)...
- Development of inhibitors of the calcium-activated chloride channel TMEM16aMarc O Anderson; Fiscal Year: 2013..SAR of the modular 2-amino-4-arylthiazole scaffold for its efficacy to inhibit the TMEM16A, the first characterized CaCC. The central hypotheses of this proposal are: (a) the molecular structure of the 2-amino-4-arylthiazoles can be ..
- Lily Y Jan; Fiscal Year: 2016..For example, CaCC contributes to signal amplification of sensory inputs and regulation of excitability of both sensory and central ..
- TMEM16A Channel Stoichiometry and Subunit InteractionJason Tien; Fiscal Year: 2013DESCRIPTION (provided by applicant): The calcium-activated chloride channel (CaCC) was first observed in salamander retina in the early 1980s and has since then been found to be responsible for diverse phenomena ranging from signal ..
- Renzhi Han; Fiscal Year: 2016..ten proteins all possessing eight transmembrane domains with proved or putative calcium-activated chloride channel (CaCC) functions. Mutations in the ANO5 gene (encoding Ano5) lead to muscular dystrophies in human patients...
- Investigating the neuronal physiology of TMEM16A Ca++ activated Cl- channelsJAMES BERG; Fiscal Year: 2012..in dorsal root ganglion (DRG) neurons where (due to high intracellular chloride concentration), the nature of CaCC opening is excitatory...
- THOMAS JOHN BRETT; Fiscal Year: 2016..Finally, we will address the functional role of CLCA1 features in CaCC activation and the role of the channel in mucous cell metaplasia...
- H Criss Hartzell; Fiscal Year: 2016..It is well-established that hBest1 encodes a Ca-activated chloride channel (CaCC) that is expressed in the basolateral membrane of the retinal pigment epithelium (RPE) and that bestrophinopathies ..
- Thomas L Pallone; Fiscal Year: 2014..In turn, depolarization occurs through a combination of Ca2+ dependent Cl- channel (CaCC) activation and K+ channel inhibition...
- Neural and Cognitive Correlates of Methamphetamine Use in SchizophreniaRUTH EILEEN SALO; Fiscal Year: 2012..be examined: 1) dorsolateral prefrontal cortex (DLPFC);2) Rostral;and 3) Caudal anterior cingulate cortex (rACC and cACC);as well as 4) a control region the primary visual cortex (PVC)...
- BESTROPHIN AND RETINAL DISEASEAlan Marmorstein; Fiscal Year: 2009..This led to the hypothesis that Best1 is a Ca2+ activated Cl- channel (CaCC) that generates the LP, and that BVMD results from loss of Best1 CaCC activity...
- BYPASSING THE SECRETORY DEFECT IN CYSTIC FIBROSISKim Barrett; Fiscal Year: 2000..for chloride transport mediated by increases in intracellular calcium and a calcium-activated chloride channel (CaCC). However, both the cAMP and calcium-mediated pathways are defective in the intestines...
- REGULATION OF GROWTH FACTORS AND EMBRYOGENESISARNOLD RIZZINO; Fiscal Year: 2005..the transcription factor Sox-2; an octamer binding motif, which binds the transcription factor Oct-3; and a GT/CACC box, which binds the transcription factors Spi and Sp3...
- NEURAL AND MECHANICAL REGULATION OF SLOW MYOSINKaryn Esser; Fiscal Year: 2004..Further analyses have identified that the CACC and MEF2 sites within this 270 bp region cooperate in regulating transcription in response to slow innervation...
- Neural Correlates of Methamphetamine Use in Schizophrenia: An MRS StudyRuth Salo; Fiscal Year: 2007..via MRS within Dorsolateral Prefrontal White Matter [WM], Rostral and Caudal Anterior Cingulate Cortex [rACC and cACC] as well as a control region the mesial occipital cortex...
- REGULATION OF CHLORIDE ION CONDUCTANCE IN PANCREAS DUCTCalvin Cotton; Fiscal Year: 2002..The rationale for this approach rests upon the observation that Ca2+-activated C1-conductance (CACC) is preserved in human CF airway epithelia and that organ-specific disease severity in the CF knockout mouse is ..
- Acupuncture/Functional Imaging of the BrainZang Hee Cho; Fiscal Year: 2002....
- Ion Transport and Mucus Clearance in CF AirwaysRobert Tarran; Fiscal Year: 2007..Based on these observations, the specific aims of this proposal are (1) to identify sensors of ASL volume, (2) to understand how ASL volume regulation is transduced and (3) to normalize CF airway surface liquid volume regulation. ..
- RENAL TRANSPORT OF NONELECTROLYTES, SALT AND WATERJames Schafer; Fiscal Year: 2002..These observations will provide important information regarding the physiological or pathophysiological circumstances under which AVP would contribute to salt retention. ..
- Matrix Metalloproteinases, Exercise, and Muscle DamageDavid Allen; Fiscal Year: 2008..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
- The Human PFC Response to Drug Cues: Outcome Representation vs. Cognitive ControStefan Ursu; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- TRAINING IN MOLECULAR AND CELL BIOLOGY OF CANCERBENDICHT PAULI; Fiscal Year: 2007..Specialized support facilities are provided by the Cornell Biotechnology Program, computer facilities, center for research animal resources (including mouse transgenic facilities), and library system. [unreadable] [unreadable]..
- 3D Imaging of electrical activity in myocardial tissueArkady Pertsov; Fiscal Year: 2007..Successful completion of this project will break ground for a new technology, the 3D imaging of electrical activation in the heart. ..
- Study of Tritonia crawl circuit and ciliated motor cellsOWEN WOODWARD; Fiscal Year: 2005..This project may also contribute to the understanding and treatment of motor system disorders as well as demonstrate how the CNS may control non-muscular motor behaviors. ..
- A New Method for Retinal ImagingAlan Marmorstein; Fiscal Year: 2005..One form of basal deposit, basal linear deposits, are more common in AMD eyes than age-matched controls. A positive outcome to this study would warrant future clinical trials. ..
- Chloride SignalingH Hartzell; Fiscal Year: 2003..in the roles of chloride in membrane trafficking, neuroscientists interested in the signaling of chloride channels, transport physiologists involved in ion homeostasis, and geneticists interested in channelopathies ..
- ORGAN-SPECIFIC VASCULAR ARREST OF MALIGNANT CELLSBENDICHT PAULI; Fiscal Year: 2002..Understanding the molecular principles that govern extravasation will ultimately allow us to develop strategies in anti-metastatic therapies. ..