CKLiK

Summary

Gene Symbol: CKLiK
Description: calcium/calmodulin dependent protein kinase ID
Alias: CKLiK, CaM-K1, CaMKID, calcium/calmodulin-dependent protein kinase type 1D, CaM kinase ID, CamKI-like protein kinase, caM kinase I delta, caM-KI delta, caMKI delta
Species: human

Top Publications

  1. ncbi Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function
    Sandra Verploegen
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 106:1076-83. 2005
  2. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
  3. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  4. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
  5. doi CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes
    M Tarnowski
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland
    J Perinatol . 2017
  6. pmc Investigation into the promoter DNA methylation of three genes (CAMK1D, CRY2 and CALM2) in the peripheral blood of patients with type 2 diabetes
    Jia Cheng
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P R China Department of Clinical Medicine, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, P R China
    Exp Ther Med 8:579-584. 2014
  7. ncbi A novel SVM-ID3 hybrid feature selection method to build a disease model for melanoma using integrated genotyping and phenotype data from dbGaP
    Yeşim Aydin Son
    Medical Informatics Department and Bioinformatics Graduate Program Graduate School of Informatics, Middle East Technical University Ankara, Turkey
    Stud Health Technol Inform 205:501-5. 2014
  8. pmc Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus
    Marie P Fogarty
    Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 10:e1004633. 2014
  9. doi Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
    Y P Yuan
    Department of Respiration, Shanghai Pudong New Area People s Hospital, Shanghai, China
    Genet Mol Res 13:8862-9. 2014
  10. doi Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study
    Francesca Frau
    Hypertension and Related Disease Centre, AOU University of Sassari, Sassari, Italy
    Pharmacogenomics 15:1643-52. 2014

Research Grants

Scientific Experts

  • Valeriya Lyssenko
  • Ary Gadelha
  • Xiao Shu
  • Steven A Haney
  • James Meigs
  • H Sakagami
  • Harald Staiger
  • S S Hook
  • Peter Gaines
  • Matthias B Schulze
  • Tsuneyuki Oikawa
  • Hana Lango Allen
  • Niels Grarup
  • DHARAMBIR SANGHERA
  • Xiaomu Kong
  • Sonia Caprio
  • Leif Groop
  • Torben Hansen
  • Markku Laakso
  • Eleftheria Zeggini
  • M Tarnowski
  • Jian Lin
  • Nadya Dimitrova
  • Lina Wang
  • Y Wenger
  • Jing Hong
  • Xiaoyan Xing
  • Xuelian Zhang
  • Wenying Yang
  • J C Lara-Riegos
  • Francesca Frau
  • Yeşim Aydin Son
  • Marie P Fogarty
  • C L Avery
  • Y P Yuan
  • Jia Cheng
  • Rajesh Ramakrishnan
  • Marco Alberto Gamboa-Meléndez
  • M Imamura
  • Karen L Mohlke
  • D Schleinitz
  • Jie Wen
  • H Hirose
  • Jianhua Zhao
  • S Maeda
  • Y Nakamura
  • Dai Zhan Zhou
  • K Kaku
  • Y Tanaka
  • Xianshu Wang
  • Annemarie M Simonis-Bik
  • R Kawamori
  • A Kashiwagi
  • S Omori
  • Eun Seok Kang
  • Trine Welløv Boesgaard
  • X Lin
  • Georgia Salanti
  • Ema C Brito
  • Kristian Hveem
  • Claudia Langenberg
  • Michael Boehnke
  • Laura J Scott
  • Timothy M Frayling
  • Andrew D Morris
  • Felicity Payne
  • Frank B Hu
  • Harald Grallert
  • Ines Barroso
  • Kristin Ardlie
  • Thomas Illig
  • David Altshuler
  • Benjamin F Voight
  • Oluf Pedersen
  • Mark I McCarthy
  • Nicholas J Wareham
  • Colin N A Palmer
  • Johanna Kuusisto
  • Andrew T Hattersley
  • Anna Bergamaschi
  • Robert B White
  • Akifumi Kamata
  • Sandra Verploegen
  • Hiroshi Tokumitsu
  • Toshiyuki Yamada
  • D Malinowski
  • A Pawlik
  • K Safranow
  • V Dziedziejko
  • W Buzgariu

Detail Information

Publications50

  1. ncbi Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function
    Sandra Verploegen
    Molecular Immunology Lab, Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Blood 106:1076-83. 2005
    ..Recently, we identified a novel Ca2+/calmodulin-dependent kinase I-like kinase, CKLiK, which exhibits restricted mRNA expression to human granulocytes...
  2. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  3. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  4. pmc Genotype score in addition to common risk factors for prediction of type 2 diabetes
    James B Meigs
    General Medicine Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 359:2208-19. 2008
    ..We tested the hypothesis that knowledge of these loci allows better prediction of risk than knowledge of common phenotypic risk factors alone...
  5. doi CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes
    M Tarnowski
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland
    J Perinatol . 2017
    ..The aim of this study was to examine the association between CDKN2A/2B rs10811661 and CDC123/CAMK1D rs12779790 gene polymorphisms and GDM...
  6. pmc Investigation into the promoter DNA methylation of three genes (CAMK1D, CRY2 and CALM2) in the peripheral blood of patients with type 2 diabetes
    Jia Cheng
    Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P R China Department of Clinical Medicine, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, P R China
    Exp Ther Med 8:579-584. 2014
    ..The results demonstrated that the promoters of these three genes were hypomethylated in the peripheral blood of all the subjects, and DNA methylation of these three genes did not contribute to the risk of T2D...
  7. ncbi A novel SVM-ID3 hybrid feature selection method to build a disease model for melanoma using integrated genotyping and phenotype data from dbGaP
    Yeşim Aydin Son
    Medical Informatics Department and Bioinformatics Graduate Program Graduate School of Informatics, Middle East Technical University Ankara, Turkey
    Stud Health Technol Inform 205:501-5. 2014
    ..The performance results of the proposed hybrid model, on melanoma dataset are 79.07% of sensitivity and 0.81 of area under ROC curve. ..
  8. pmc Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus
    Marie P Fogarty
    Department of Genetics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 10:e1004633. 2014
    ..These results suggest that rs11257655 affects transcriptional activity through altered binding of a protein complex that includes FOXA1 and FOXA2, providing a potential molecular mechanism at this GWAS locus. ..
  9. doi Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
    Y P Yuan
    Department of Respiration, Shanghai Pudong New Area People s Hospital, Shanghai, China
    Genet Mol Res 13:8862-9. 2014
    ..In conclusion, CAMK1D, ALB, KIT, and DDX3Y were chosen as candidate genes, which have the potential to be biomarkers or candidate target molecules to apply in clinical diagnosis and treatment of COPD...
  10. doi Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study
    Francesca Frau
    Hypertension and Related Disease Centre, AOU University of Sassari, Sassari, Italy
    Pharmacogenomics 15:1643-52. 2014
    ..Essential hypertension arises from the combined effect of genetic and environmental factors. A pharmacogenomics approach could help to identify additional molecular mechanisms involved in its pathogenesis...
  11. doi Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes
    J C Lara-Riegos
    Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química Universidad Nacional Autónoma de México Instituto Nacional de Medicina Genómica, Mexico
    Gene 565:68-75. 2015
    ..In conclusion, these findings support an association of genetic polymorphisms to develop T2D in Maya population...
  12. pmc Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development
    Nadya Dimitrova
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts Molecular, Cellular and Developmental Biology Department, Yale University, New Haven, Connecticut
    Cancer Discov 6:188-201. 2016
    ..These findings demonstrate that stromal miR-143/145 promotes tumorigenesis and caution against the use of these miRNAs as agents in cancer therapeutics...
  13. pmc Loss of neurogenesis in Hydra leads to compensatory regulation of neurogenic and neurotransmission genes in epithelial cells
    Y Wenger
    Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva iGE3, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Philos Trans R Soc Lond B Biol Sci 371:20150040. 2016
    ..Hence epitheliomuscular cells seemingly enhance their sensing ability when neurogenesis is compromised. This unsuspected plasticity might reflect the extended multifunctionality of epithelial-like cells in early eumetazoan evolution. ..
  14. pmc The Association of Type 2 Diabetes Loci Identified in Genome-Wide Association Studies with Metabolic Syndrome and Its Components in a Chinese Population with Type 2 Diabetes
    Xiaomu Kong
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    PLoS ONE 10:e0143607. 2015
    ..The study also provides insight into the pleotropic effects of genome-wide association loci of diabetes on metabolic regulation. ..
  15. doi Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity
    Ary Gadelha
    Department of Psychiatry, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, Brazil Electronic address
    Schizophr Res 172:60-7. 2016
    ..ZFPM2 and MAD1L1 were the only two genes with more than one hit at 10(-6) order of p value. Therefore, Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to SCZ physiopathology. ..
  16. pmc Genetic variants associated with lean and obese type 2 diabetes in a Han Chinese population: A case-control study
    Xiaomu Kong
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, P R China
    Medicine (Baltimore) 95:e3841. 2016
    ..Moreover, the study highlights the contribution of known T2D genomic loci to the heterogeneity of lean and obese T2D in Chinese Hans. ..
  17. pmc MiR674 inhibits the neuraminidase-stimulated immune response on dendritic cells via down-regulated Mbnl3
    Jian Lin
    Life Science College, Nanjing Agricultural University, Weigang, Nanjing, Jiangsu, PR China
    Oncotarget 7:48978-48994. 2016
    ..Collectively, our data shed new light on the roles of and mechanisms involved in the repression of DCs by miRNAs, which may contribute to efforts to develop a prophylaxis for the influenza virus...
  18. pmc Long non-coding RNA LOC283070 mediates the transition of LNCaP cells into androgen-independent cells possibly via CAMK1D
    Lina Wang
    Department of Biochemistry and Molecular Biology, Shandong University School of MedicineJinan, P R China Central Laboratory, The Second Hospital of Shandong UniversityJinan, P R China
    Am J Transl Res 8:5219-5234. 2016
    ..The present study is to investigate the role of long non-coding RNAs (lncRNAs) in the development of androgen independence in prostate cancer and its underlying mechanism...
  19. pmc RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation
    Steven Haney
    Target Generation Unit, Pfizer Research Technology Center, Cambridge, Massachusetts, USA
    PLoS ONE 8:e64946. 2013
    ....
  20. pmc Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
    C L Avery
    Department of Epidemiology, Bank of America Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Pharmacogenomics J 14:6-13. 2014
    ..0 × 10(-8)). Simulations suggested that additional efforts, including longitudinal modeling to increase statistical power, are likely needed to identify potentially important pharmacogenomic effects. ..
  21. pmc Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population
    Marco Alberto Gamboa-Meléndez
    Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
    Diabetes 61:3314-21. 2012
    ..Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects...
  22. pmc Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    Annemarie M Simonis-Bik
    Diabetes Center, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 59:293-301. 2010
    ..In this study we used hyperglycemic clamps with three different stimuli to test associations between these novel loci and various measures of beta-cell function...
  23. doi Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population
    M Imamura
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Diabetologia 54:3071-7. 2011
    ..The aim of the present study was to ascertain the role of these four variants in conferring susceptibility to type 2 diabetes in the Japanese population...
  24. pmc Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway
    Rajesh Ramakrishnan
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Cell Physiol 227:609-17. 2012
    ....
  25. doi Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese
    Dai Zhan Zhou
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, PR China
    J Hum Genet 55:810-5. 2010
    ..15(1.10-1.21); P=1.93 × 10(-8)). This large population-based study and meta-analysis further confirmed the modest effects of the JAZF1, TSPAN8/LGR5 and HHEX-IDE loci on type 2 diabetes in Chinese and other East Asians...
  26. pmc Identification of new genetic risk variants for type 2 diabetes
    Xiao Ou Shu
    Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS Genet 6:e1001127. 2010
    ..Our study provides strong evidence for a novel T2D susceptibility locus at 13q31.1 and the presence of new independent risk variants near regions (10p13 and 15q22.2) reported by previous GWAS...
  27. pmc Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Xianshu Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Hum Mol Genet 19:2886-97. 2010
    ..Upon further validation, these SNPs together with other genetic and environmental factors may improve breast cancer risk assessment in these populations...
  28. pmc Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults
    Ema C Brito
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetes 58:1411-8. 2009
    ....
  29. ncbi Ca(2+)/CaM-dependent kinases: from activation to function
    S S Hook
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Annu Rev Pharmacol Toxicol 41:471-505. 2001
    ..Gene transcription has been chosen as the functional endpoint to illustrate the recent advances in Ca(2+)/CaM-mediated signal transduction mechanisms...
  30. ncbi Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells
    Yumi Ishikawa
    Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
    FEBS Lett 550:57-63. 2003
    ..This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells...
  31. ncbi Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Cell Genetics, Sasaki Institute, Tokyo 101 0062, Japan
    Exp Cell Res 294:39-50. 2004
    ..Because the gene exhibited about 90% homology with the human calcium-calmodulin-dependent kinase I-like kinase (CKLiK) gene, it was identified as a mouse homologue of human CKLiK...
  32. ncbi Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons
    Hiroyuki Sakagami
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
    Eur J Neurosci 22:2697-707. 2005
    ..Our present study provides the first evidence for the possible involvement of CaMKIdelta in nuclear functions through its nuclear translocation in response to stimuli that trigger intracellular Ca2+ influx...
  33. ncbi Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
    Akifumi Kamata
    Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
    Neurosci Res 57:86-97. 2007
    ....
  34. doi Genome-wide discovery of Pax7 target genes during development
    Robert B White
    School of Exercise Biomedical and Health Science, Edith Cowan University, Joondalup, Western Australia, Australia
    Physiol Genomics 33:41-9. 2008
    ..This analysis gives us greater insight into the direct functional role played by Pax7 during embryonic development...
  35. pmc A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils
    Peter Gaines
    Department of Biological Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA
    Exp Hematol 36:832-44. 2008
    ..we have investigated the role of two members of the calcium/calmodulin-dependent protein kinase (CaMK) signaling cascade, CaMK I-like kinase (CKLiK) and CaMKKalpha, in regulating neutrophil differentiation and functional activation.
  36. pmc Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes
    Niels Grarup
    Steno Diabetes Center, Copenhagen, Denmark
    Diabetes 57:2534-40. 2008
    ....
  37. pmc Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tubingen, Tubingen, Germany
    PLoS ONE 3:e3019. 2008
    ..e., obesity, impaired insulin secretion, and insulin resistance...
  38. doi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  39. doi Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Hum Genet 54:162-8. 2009
    ..on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians...
  40. pmc Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort
    Jie Wen
    Department of Endocrinology, Shanghai Medical College Fudan University, Shanghai, China
    PLoS ONE 5:e9153. 2010
    ..In the present study, we evaluated the influence of 17 genetic variants from 15 candidate loci, identified in type 2 diabetes GWASs and the metaanalysis, in a Han Chinese cohort...
  41. pmc CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Mol Oncol 2:327-39. 2008
    ..Our findings identify CAMK1D as a novel amplified oncogene linked to EMT in breast cancer, and as a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors...
  42. doi Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals
    S Omori
    Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, Yokohama, Kanagawa 230 0045, Japan
    Diabetologia 52:1554-60. 2009
    ..To examine further the roles of these new loci, we performed a replication study for the association of these single-nucleotide polymorphism (SNP) loci with the disease in three independent Japanese populations...
  43. pmc Underlying genetic models of inheritance in established type 2 diabetes associations
    Georgia Salanti
    Clinical and Molecular Epidemiology Unit and Clinical Trials and Evidence Based Medicine Unit, Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    Am J Epidemiol 170:537-45. 2009
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments...
  44. doi Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits
    D Schleinitz
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig 04109, Germany
    Horm Metab Res 42:14-22. 2010
    ..This is compatible with the modest effect size of these "second sweep" variants, which will require large-scale association studies on quantitative traits to clarify their role in the pathophysiology of T2D...
  45. pmc Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study
    Matthias B Schulze
    Public Health Nutrition Unit, Technische Universitat Munchen, Freising, Germany
    Diabetes Care 32:2116-9. 2009
    ..We investigated whether metabolic biomarkers and single nucleotide polymorphisms (SNPs) improve diabetes prediction beyond age, anthropometry, and lifestyle risk factors...
  46. doi Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea
    Eun Seok Kang
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
    Transplantation 88:693-8. 2009
    ..Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea...
  47. pmc Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
    Trine Welløv Boesgaard
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 4:e7236. 2009
    ....
  48. pmc Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes
    Hana Lango Allen
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, U K
    Diabetes 59:266-71. 2010
    ..We investigated the hypothesis that common polygenic variants that predispose to type 2 diabetes might account for the difference in age at diagnosis...
  49. ncbi Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase
    S Verploegen
    Department of Pulmonary Diseases, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
    Blood 96:3215-23. 2000
    ..This has been termed CaMKI-like kinase (CKLiK)...
  50. pmc Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 59:751-5. 2010
    ..Our goal was to investigate if any type 2 diabetes variants uncovered through genome-wide association studies (GWAS) impact BMI in childhood...

Research Grants7

  1. Sonia Caprio; Fiscal Year: 2014
    ....
  2. MALIGNANT GERM CELL TUMORS IN CHILDREN
    Xiao Shu; Fiscal Year: 2001
    ..The relatively large sample size will provide sufficient statistical power to address the hypotheses being investigated. ..
  3. Breast Cancer Survival: Lifestyle and Genetic Determinants
    Xiao Ou Shu; Fiscal Year: 2010
    ..The proposed study, built on successfully implemented cohort studies, will be extremely timely and cost-efficient. ..
  4. Soy Food and Coronary Heart Disease in Women
    Xiao Ou Shu; Fiscal Year: 2008
    ....
  5. Soyfood, gene polymorphisms and endometrial cancer risk
    Xiao Ou Shu; Fiscal Year: 2010
    ..abstract_text> ..
  6. Phenotype-Genotype Interactions and Type 2 Diabetes
    James Meigs; Fiscal Year: 2005
    ..Results will provide a foundation for future laboratory efforts and will increase understanding of phenotype-genotype interactions in diabetes pathogenesis. ..
  7. Role of Lamin B Receptor in Neutrophil Maturation and Functional Activation
    Peter Gaines; Fiscal Year: 2007
    ..The results may also offer important insight into the pathogenesis of potentially fatal hematologic disorders. [unreadable] [unreadable] [unreadable]..