CKAP4

Summary

Gene Symbol: CKAP4
Description: cytoskeleton associated protein 4
Alias: CLIMP-63, ERGIC-63, p63, cytoskeleton-associated protein 4, 63 kDa membrane protein, 63-kDa cytoskeleton-linking membrane protein, transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment, type-II transmembrane protein p63
Species: human

Top Publications

  1. pmc Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein
    D I Mundy
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 116:135-46. 1992
  2. ncbi Reassessment of the subcellular localization of p63
    A Schweizer
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 108:2477-85. 1995
  3. ncbi A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein
    A Schweizer
    Department of Pharmacology, University of Basel, Switzerland
    J Cell Sci 104:685-94. 1993
  4. ncbi Protein palmitoylation in membrane trafficking
    D I Mundy
    Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK
    Biochem Soc Trans 23:572-6. 1995
  5. pmc Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment
    D R Klopfenstein
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Biol 153:1287-300. 2001
  6. ncbi Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4)
    Tahir M Razzaq
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 278:42679-85. 2003
  7. pmc Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules
    Cécile Vedrenne
    Biozentrum, University of Basel, Switzerland
    Mol Biol Cell 16:1928-37. 2005
  8. ncbi CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients
    Thomas P Conrads
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:37836-43. 2006
  9. pmc Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method
    Jun Zhang
    The Whitney Laboratory, Department of Neuroscience, University of Florida, St Augustine, Florida 32080, USA
    Mol Cell Proteomics 7:1378-88. 2008
  10. pmc Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus
    Evelyn N Kouwenhoven
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 6:e1001065. 2010

Research Grants

  1. Luis Alfonso Martinez; Fiscal Year: 2016
  2. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
  3. Satrajit Sinha; Fiscal Year: 2014
  4. Cellular and molecular biology of lung surfactant
    Aron B Fisher; Fiscal Year: 2013
  5. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
  6. Xinbin Chen; Fiscal Year: 2015
  7. Guy Howard; Fiscal Year: 2015
  8. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2010
  9. Takeshi Kurita; Fiscal Year: 2014
  10. Rose Anne Romano; Fiscal Year: 2015

Detail Information

Publications249 found, 100 shown here

  1. pmc Mitosis and inhibition of intracellular transport stimulate palmitoylation of a 62-kD protein
    D I Mundy
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 116:135-46. 1992
    ..We suggest that the acylation and deacylation of p62 may be important in vesicular transport and that this process may be regulated during mitosis...
  2. ncbi Reassessment of the subcellular localization of p63
    A Schweizer
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 108:2477-85. 1995
    b>p63 is a type II integral membrane protein that has previously been suggested to be a resident protein of a membrane network interposed between the ER and the Golgi apparatus...
  3. ncbi A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein
    A Schweizer
    Department of Pharmacology, University of Basel, Switzerland
    J Cell Sci 104:685-94. 1993
    The recently identified 63 kDa membrane protein, p63, is a resident protein of a membrane network interposed in between rough ER and Golgi apparatus. To characterize p63 at the molecular level a 2...
  4. ncbi Protein palmitoylation in membrane trafficking
    D I Mundy
    Cell Biology Laboratory, Imperial Cancer Research Fund, London, UK
    Biochem Soc Trans 23:572-6. 1995
  5. pmc Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment
    D R Klopfenstein
    Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Biol 153:1287-300. 2001
    The microtubule-binding integral 63 kD cytoskeleton-linking membrane protein (CLIMP-63; former name, p63) of the rough endoplasmic reticulum (ER) is excluded from the nuclear envelope...
  6. ncbi Functional regulation of tissue plasminogen activator on the surface of vascular smooth muscle cells by the type-II transmembrane protein p63 (CKAP4)
    Tahir M Razzaq
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    J Biol Chem 278:42679-85. 2003
    ..of VSMC and unambiguously identified as the rat homologue of the human type-II transmembrane protein p63 (CKAP4) by matrix-assisted laser desorption ionization and nano-electrospray tandem mass spectrometry of tryptic ..
  7. pmc Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules
    Cécile Vedrenne
    Biozentrum, University of Basel, Switzerland
    Mol Biol Cell 16:1928-37. 2005
    ....
  8. ncbi CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients
    Thomas P Conrads
    Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 281:37836-43. 2006
    ..This study demonstrates that cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor, binds with high affinity to APF...
  9. pmc Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method
    Jun Zhang
    The Whitney Laboratory, Department of Neuroscience, University of Florida, St Augustine, Florida 32080, USA
    Mol Cell Proteomics 7:1378-88. 2008
    ..isolation capture and analysis (or PICA) to identify PAT-substrate relationships in a living vertebrate system and demonstrate its effectiveness by identifying CKAP4/p63 as a substrate of DHHC2, a putative tumor suppressor.
  10. pmc Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus
    Evelyn N Kouwenhoven
    Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS Genet 6:e1001065. 2010
    Heterozygous mutations in p63 are associated with split hand/foot malformations (SHFM), orofacial clefting, and ectodermal abnormalities...
  11. pmc Role of the PI3-kinase signaling pathway in trafficking of the surfactant protein A receptor P63 (CKAP4) on type II pneumocytes
    Altaf S Kazi
    Institute for Environmental Medicine, Univ of Pennsylvania School of Medicine, Philadelphia, 19104 6068, USA
    Am J Physiol Lung Cell Mol Physiol 299:L794-807. 2010
    ..Previously, an SP-A receptor, P63 (CKAP4), on type II pneumocyte plasma membranes (PM) was identified by chemical cross-linking techniques...
  12. pmc Mechanisms determining the morphology of the peripheral ER
    Yoko Shibata
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 143:774-88. 2010
    ..These proteins may generate sheets by stabilizing the high curvature of edges...
  13. pmc Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells
    Hanief M Shahjee
    Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Exp Clin Cancer Res 29:160. 2010
    ..its antiproliferative activity in primary normal bladder epithelial cells via cytoskeletal associated protein 4 (CKAP4)...
  14. doi Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology
    S E Clements
    St John s Institute of Dermatology, King s College London Guy s Campus, London SE1 9RT, UK
    Br J Dermatol 167:134-44. 2012
    ..syndrome is an autosomal dominant ectodermal dysplasia disorder caused by mutations in the transcription factor p63. Clinically, the skin is dry and often fragile; other features can include partial eyelid fusion (ankyloblepharon), ..
  15. pmc Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling
    Sonia L Planey
    Whitney Laboratory, Department of Neuroscience, University of Florida, St Augustine, FL 32080, USA
    Mol Biol Cell 20:1454-63. 2009
    Previously, we identified cytoskeleton-associated protein 4 (CKAP4) as a major substrate of the palmitoyl acyltransferase, DHHC2, using a novel proteomic method called palmitoyl-cysteine identification, capture and analysis (PICA)...
  16. ncbi Dominant negative p63 isoform expression in head and neck squamous cell carcinoma
    Joseph C Sniezek
    Department of Otolaryngology Head and Neck Surgery, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859 5000, USA
    Laryngoscope 114:2063-72. 2004
    b>p63, a member of the p53 family of genes, is vital for normal epithelial development and may play a critical role in epithelial tumor formation...
  17. doi Giant cell tumor of bone express p63
    Brendan C Dickson
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 21:369-75. 2008
    b>p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms...
  18. ncbi Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer
    Rajal B Shah
    Deparment of Pathology and Urology, University of Michigan School of Medicine and Comprenhensive Cancer Center, Ann Arbor, Michigan 48109, USA
    Am J Surg Pathol 26:1161-8. 2002
    ..A recently identified basal cell marker p63, a p53 homologue, stains basal cell nuclei but not secretory cells...
  19. ncbi Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    b>p63 is a p53-related DNA-binding protein that helps regulate differentiation and proliferation in epithelial progenitor cells. Its expression has never been evaluated in the human gastrointestinal tract...
  20. ncbi Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers
    Joseph T Rabban
    Department of Pathology, University of California, San Francisco, CA 94143, USA
    Mod Pathol 19:1351-7. 2006
    ..The diagnosis may be even more challenging in needle core biopsies. Immunohistochemical expression of p63 and c-kit distinguishes adenoid cystic carcinoma from invasive cribriform carcinoma and ductal carcinoma in situ...
  21. ncbi Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas
    Paul C Edwards
    Department of Dental Medicine, Division of Oral Pathology, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97:613-9. 2004
    The purpose of this study was to determine the extent of p63 immunoreactivity in the malignant salivary gland neoplasms adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) and to compare this to the expression ..
  22. doi Gene expression profiling identifies p63 as a diagnostic marker for giant cell tumor of the bone
    Cheng Han Lee
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 21:531-9. 2008
    ..types, and significance analysis of microarray identified several genes including TP73L (encoding the p63 protein) that are significantly highly expressed in GCTOB relative to these other tumors...
  23. doi The use of p63 as an effective immunomarker in the diagnosis of pulmonary squamous cell carcinomas on de-stained bronchial lavage cytological smears
    M Uke
    Division of Cytology, Tata Memorial Hospital, Mumbai, India
    Cytopathology 21:56-63. 2010
    ..Lately, p63 antibody has been used for distinguishing squamous cell carcinoma from SCLC and adenocarcinoma...
  24. pmc Expression of p63 in anaplastic large cell lymphoma but not in classical Hodgkin's lymphoma
    Gabriela Gualco
    Consultoria em Patologia, 18602 010 Botucatu, Sao Paulo, Brazil
    Hum Pathol 39:1505-10. 2008
    Immunohistochemical determination of p63 protein is frequently used in the pathologic diagnosis of nonhematological solid tumors...
  25. doi An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63
    W Glenn McCluggage
    Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland
    Am J Surg Pathol 34:525-32. 2010
    ..Cases were stained with AE1/3, chromogranin, CD56, synaptophysin, PGP9.5, TTF1, p16, p63, CK7, CK20, neurofilament, and CD99...
  26. pmc Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha
    Rose Anne Romano
    Department of Biochemistry, Center for Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Development 137:1431-9. 2010
    The transcription factor p63 plays an essential role in epidermal morphogenesis. Animals lacking p63 fail to form many ectodermal organs, including the skin and hair follicles...
  27. pmc p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation
    H van Bokhoven
    Department of Human Genetics, University Medical Centre, Nijmegen, The Netherlands
    Am J Hum Genet 69:481-92. 2001
    b>p63 mutations have been associated with EEC syndrome (ectrodactyly, ectodermal dysplasia, and cleft lip/palate), as well as with nonsyndromic split hand-split foot malformation (SHFM)...
  28. ncbi p63 expression in normal skin and usual cutaneous carcinomas
    Jorge S Reis-Filho
    IPATIMUP, Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    J Cutan Pathol 29:517-23. 2002
    b>p63 is a p53 homologue that is mapped to chromosome 3q27. This gene encodes six different isoforms, which have either transactivating or dominant negative effects on p53-reporter genes...
  29. ncbi Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study
    John A Ozolek
    Department of Pathology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 131:530-7. 2007
    ..One feature of malignant glandular lesions is loss of the basal/myoepithelial layer. The immunophenotype of the basal/myoepithelial layer has not been fully examined in benign glandular lesions of the sinonasal tract...
  30. pmc Analysis of the p63 gene in classical EEC syndrome, related syndromes, and non-syndromic orofacial clefts
    L L Barrow
    Department of Otolaryngology Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA
    J Med Genet 39:559-66. 2002
    ..EEC syndrome has been linked to chromosome 3q27 and heterozygous p63 mutations were detected in unrelated EEC families...
  31. pmc Novel in vivo targets of DeltaNp63 in keratinocytes identified by a modified chromatin immunoprecipitation approach
    Barbara Birkaya
    Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14214, USA
    BMC Mol Biol 8:43. 2007
    b>p63 is a transcription factor that plays an important role in skin epidermal development and differentiation...
  32. ncbi Expression of p63 in conjunctival intraepithelial neoplasia and squamous cell carcinoma
    Claudia Auw-Haedrich
    Eye Hospital, Albert Ludwigs University, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 244:96-103. 2006
    b>p63 is a homologue of the tumour suppressor gene p53, which is expressed in human basal squamous epithelium...
  33. pmc Claudin-1 is a p63 target gene with a crucial role in epithelial development
    Teresa Lopardo
    Department of Biomolecular Sciences and Biotechnology, University of Milan, Milan, Italy
    PLoS ONE 3:e2715. 2008
    ..b>p63 is a transcription factor essential for proliferation of stem cells and for stratification in epithelia, mutated in ..
  34. ncbi The EEC syndrome and SHFM: report of two cases and mutation analysis of p63 gene
    Hacer Ergin
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Turk J Pediatr 52:529-33. 2010
    The p63 gene is a transcription factor and a member of the p53 family. Heterozygote mutation of the p63 gene is suggested in a number of human syndromes including limb development and/or ectodermal dysplasia...
  35. ncbi Immunohistochemical detection of GLUT1, p63 and phosphorylated histone H1 in head and neck squamous intraepithelial neoplasia: evidence for aberrations in hypoxia-related, cell cycle- and stem-cell-regulatory pathways
    D E Burstein
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Histopathology 48:708-16. 2006
    ..Detection and grading of early squamous intraepithelial neoplasia may at times be problematic. The aim of this study was to examine the ability of immunomarkers GLUT1, phospho-histone H1 and p63 to detect such early lesions.
  36. ncbi Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture
    Sabine Roman
    Digestive Physiology, Pavillon H, Hopital Edouard Herriot, Place d Arsonval, 69437 Lyon Cedex 03, France
    Am J Physiol Gastrointest Liver Physiol 293:G45-53. 2007
    b>p63 is a member of the p53 protein family that regulates differentiation and morphogenesis in epithelial tissues and is required for the formation of squamous epithelia...
  37. doi Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study
    Wenle Wang
    Department of Pathology, The John Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:851-7. 2008
    ..sent to our consultation service in 2006 from a single institution, which frequently uses a triple cocktail stain [p63, high molecular weight cytokeratin (HMWCK), alpha-methyl acyl-Coa racemase (AMACR)]...
  38. doi Immunohistochemical detection of XIAP and p63 in adenomatous hyperplasia, atypical adenomatous hyperplasia, bronchioloalveolar carcinoma and well-differentiated adenocarcinoma
    Maoxin Wu
    1Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Mod Pathol 21:553-8. 2008
    ..inhibitor of apoptosis protein (XIAP), the most potent of the inhibitor of apoptosis protein (IAP) family, and p63, a marker of bronchial reserve cells (BRC) and squamous cells, in these entities...
  39. ncbi Expression of p63 differs in peritoneal endometriosis, endometriomas, adenomyosis, rectovaginal septum endometriosis, and abdominal wall endometriosis
    Omero B Poli Neto
    Department of Surgery, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Arch Pathol Lab Med 131:1099-102. 2007
    ..One protein that plays an important role in regulating epithelial proliferation and differentiation is the 63-kDa membrane protein (p63), which is also a marker of basal and reserve cells in the female genital tract.
  40. pmc p63 promotes cell survival through fatty acid synthase
    Venkata Sabbisetti
    Department of Pathology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    PLoS ONE 4:e5877. 2009
    There is increasing evidence that p63, and specifically DeltaNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival...
  41. ncbi Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells
    Michael H Weinstein
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Mod Pathol 15:1302-8. 2002
    ..Thus, a second method of identifying basal cells might prove useful. Selective expression of p63, a homologue of p53, has been demonstrated in prostatic basal cells...
  42. ncbi Expression of the p63 and Notch signaling systems in rat testes during postnatal development: comparison with their expression levels in the epididymis and vas deferens
    Tetsuo Hayashi
    Department of Urology, Saitama Medical Center, Saitama Medical School, 1981 Tsujido, Kamoda, Kawagoe, Saitama 350 8550, Japan
    J Androl 25:692-8. 2004
    ..A member of the p53 family of genes, p63, is highly expressed in the basal layers of epithelial tissues and plays a key role in maintaining their cell ..
  43. ncbi Cytology applications of p63 and TTF-1 immunostaining in differential diagnosis of lung cancers
    Maoxin Wu
    Division of Cytopathology, Department of Pathology, Mount Sinai School of Medicine, New York, New York, USA
    Diagn Cytopathol 33:223-7. 2005
    ..We have demonstrated the role of p63 and thyroid transcription factor-1 (TTF-1) in the differential diagnosis of poorly differentiated squamous-cell ..
  44. ncbi [Detection of AMACR (P504S), P63 and 34betaE12 cocktail in the early diagnosis of prostate cancer]
    Tao Yu
    Department of Urology, Union Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350001, China
    Zhonghua Nan Ke Xue 13:222-5. 2007
    To investigate the value of detection of AMACR (P504S), P63 and 34betaE12 cocktail in the early diagnosis of prostate cancer (PCa).
  45. pmc p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
    Elisabetta Sbisà
    Istituto di Tecnologie Biomediche Sede di Bari, CNR, Via Amendola, 122 D 70126 Bari, Italy
    BMC Bioinformatics 8:S20. 2007
    The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlapping functions in pivotal cellular processes such as DNA synthesis and repair, growth arrest, apoptosis, genome stability, angiogenesis, ..
  46. ncbi Decreased expression of the p63 related proteins beta-catenin, E-cadherin and EGFR in oral lichen planus
    Majid Ebrahimi
    Department of Odontology, Umea University, Umea, Sweden
    Oral Oncol 44:634-8. 2008
    ..The p63 gene encodes six different proteins which are required for development of ectodermally derived tissues such as oral ..
  47. doi Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects
    Nadia Lo Iacono
    Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
    Development 135:1377-88. 2008
    ..SHFM-IV and Ectrodactyly-Ectodermal dysplasia-Cleft lip (EEC) are caused by mutations in p63, an ectoderm-specific p53-related transcription factor...
  48. pmc Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice
    Helen A Thomason
    Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
    J Clin Invest 120:1561-9. 2010
    ..Mutations in the transcription factor-encoding genes p63 and interferon regulatory factor 6 (IRF6) have individually been identified as causes of cleft palate; however, a ..
  49. ncbi p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue
    Bonnie J Ching
    Section of Genetics, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA
    Int J Mol Med 26:861-7. 2010
    ..Several lines of evidence implicate genetic factors in the formation of BEEC. Among them a murine p63+/+ knockout model showed the full picture of classic exstrophy of the bladder and other urogenital defects within ..
  50. ncbi Stem/progenitor and intermediate cell types and the origin of human prostate cancer
    Erik J Tokar
    Department of Zoology, Michigan State University, East Lansing, MI 48824 1312, USA
    Differentiation 73:463-73. 2005
    ..either independently capable of self-renewal or 2) arise from stem cells expressing a full spectrum of proteins (p63, cytokeratins CK5/14, CK8/18, and glutathione-S-transferase-pi [GST-pi]) similar to cells of the embryonic ..
  51. ncbi p63 expression in benign and malignant breast lesions
    D Stefanou
    Department of Pathology, University of Ioannina Medical School, Ioannina, Greece
    Histol Histopathol 19:465-71. 2004
    The p63 gene encodes six protein isoforms. The transactivating isoforms have similar actions with p53, while the N-isoforms inhibit transcription activation by p53 and transactivating isoforms...
  52. doi P63 expression in conjunctival proliferative diseases: pterygium and laryngo-onycho-cutaneous (LOC) syndrome
    Sarah D Atkinson
    Centre for Molecular Biosciences, School of Biomedical Sciences, Coleraine, Northern Ireland
    Curr Eye Res 33:551-8. 2008
    Compare expression of p63 in pterygium and laryngo-onycho-cutaneous (LOC) syndrome with normal conjunctiva.
  53. ncbi Influence of feeder layer on the expression of stem cell markers in cultured limbal corneal epithelial cells
    Sudha Balasubramanian
    L and T Department of Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India
    Indian J Med Res 128:616-22. 2008
    ..expression of putative stem cell markers ATP binding cassette protein (ABCG2) and keratinocyte stem cell marker: p63 and differentiation markers...
  54. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  55. doi Increased expression of p63 and survivin in cholesteatomas
    H R Park
    Department of Pathology, College of Medicine, Hallym University Sacred Heart Hospital, 896 Pyungchon Dong, Anyang, Korea
    Acta Otolaryngol 129:268-72. 2009
    This study showed increased expression of p63 and survivin in cholesteatoma. Our finding indicates a putative role of p63 and survivin in the development of certain cholesteatomas.
  56. ncbi Identification and characterization of p63 (CKAP4/ERGIC-63/CLIMP-63), a surfactant protein A binding protein, on type II pneumocytes
    Nisha Gupta
    Institute for Environmental Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Am J Physiol Lung Cell Mol Physiol 291:L436-46. 2006
    ..a major band of 63 kDa under reduced conditions that was identified as the rat homolog of the human type II transmembrane protein p63 (CKAP4/ERGIC-63/CLIMP-63) by matrix-assisted laser desorption ionization and nanoelectrospray tandem ..
  57. ncbi Expression of p63 and p73 in ameloblastomas
    Hiroyuki Kumamoto
    Division of Oral Pathology, Department of Oral Medicine and Surgery, Tohoku University Graduate School of Dentistry, Sendai 980 8575, Japan
    J Oral Pathol Med 34:220-6. 2005
    To clarify the role of p53 homologs in oncogenesis and cytodifferentiation of odontogenic tumors, expression of p63 and p73 was analyzed in ameloblastomas as well as tooth germs.
  58. ncbi Roles of p63 in differentiation of Müllerian duct epithelial cells
    T Kurita
    Department of Anatomy, University of California at San Francisco, 94143, USA
    Ann N Y Acad Sci 948:9-12. 2001
    In the mouse female reproductive tract, p63, a homologue of the p53 tumor suppressor gene, is highly expressed in basal cells of the vaginal and cervical epithelium, but not in the uterine epithelium...
  59. ncbi P63 expression in lung carcinoma: a tissue microarray study of 408 cases
    N H C Au
    Genetic Pathology Evaluation Centre, Department of Pathology and Prostate Research Centre, Vancouver General Hospital, The British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Appl Immunohistochem Mol Morphol 12:240-7. 2004
    b>p63 is a recently discovered member of the p53 family that has been shown to be important in the development of epithelial tissues...
  60. ncbi A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression
    Yonghee Lee
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Pathol 38:1003-13. 2007
    ..To clarify the lineage relationship between these subtypes, we profiled p63 localization in developing and term placental tissue, as well as in trophoblastic tumors, using antibodies specific ..
  61. doi D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients
    Einar Gudlaugsson
    Department of Pathology, Stavanger University Hospital, Stavanger, Norway
    Mod Pathol 24:502-11. 2011
    ..As myoepithelial cells are also p63 positive, we have investigated whether lymph vessel invasion identified by combined D2-40/p63 is stronger ..
  62. pmc Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63
    Bridget E Ferguson-Yates
    Department of Dermatology, University of California, San Francisco, CA, USA
    Carcinogenesis 29:70-5. 2008
    ..We hypothesized that the p53 homolog, p63, may participate in governing global repair instead of p53 in keratinocytes...
  63. ncbi p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma
    Patrick Emanuel
    Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mod Pathol 18:645-50. 2005
    ..We have investigated the possibility that immunohistochemical staining for the presence of p63, a novel epithelial stem-cell regulatory protein, could be a useful means of distinguishing these two neoplasms...
  64. ncbi Identification of DeltaN isoform and polyadenylation site choice variants in molluscan p63/p73-like homologues
    Annette F Muttray
    Laboratory of Aquatic Biomedicine, Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    Mar Biotechnol (NY) 9:217-30. 2007
    ..We report the sequences of two distinct and novel p63/p73-like mRNAs, amplified by polymerase chain reaction (PCR) from both species...
  65. doi Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases
    Adeboye O Osunkoya
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:461-7. 2008
    Aberrant diffuse expression of p63 in prostate carcinoma cells is a rare and poorly understood phenomenon...
  66. doi P63 expression in gestational trophoblastic disease: correlation with proliferation and apoptotic dynamics
    Hui Juan Zhang
    Department of Pathology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China
    Int J Gynecol Pathol 28:172-8. 2009
    b>p63 regulates cell growth and differentiation and contributes to tumorigenesis through its complex isoforms...
  67. doi Association of testicular p63 expression and spermatogenesis in androgen receptor knockout (ARKO) mice
    Jian jun Yu
    Shang Hai 6th People s Hospital, Shang Hai JiaoTong University, Shang Hai 200233, China
    Aging Male 14:72-5. 2011
    To study changes of testicular p63 expression and its effect on spermatogenic function in seminiferous tubules in androgen receptor knockout (ARKO) mice.
  68. doi Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood
    N Carolina Hernández-Acosta
    Depto Anatomía, Facultad de Medicina, 38071 La Laguna, Tenerife, Spain
    Brain Res 1372:29-40. 2011
    b>p63 and p73, family members of the tumor suppressor p53, are critically involved in the life and death of mammalian cells. They display high homology and may act in concert...
  69. pmc CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    T Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, 97239, USA
    Cell Death Dis 1:e102. 2010
    ..Gentamicin also enhanced the binding between CLIMP-63 and 14-3-3 proteins, and we also identified that 14-3-3 proteins are involved in gentamicin-induced cytotoxicity, likely by binding to CLIMP-63...
  70. ncbi Morphological and immunohistochemical changes to thymic epithelial cells in the irradiated and recovering rat thymus
    Tatsuya Irifune
    Department of Human Science, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Arch Histol Cytol 67:149-58. 2004
    ..To analyse the mechanisms for this abrupt recovery of the thymocytes after irradiation, the expression of p63 in the normal and irradiated thymus was immunohistochemically studied as the expression of this antigen may be ..
  71. ncbi Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking
    A Robinson
    University Department of Pharmacology, Oxford, UK
    Blood 88:522-30. 1996
    ..Tyrosine phosphorylation of p38 and p63 is also observed in platelets stimulated by the tyrosine kinase-linked receptor agonist collagen and by the G ..
  72. pmc Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27
    P Ianakiev
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
    Am J Hum Genet 67:59-66. 2000
    ..Results of gene-targeting studies have demonstrated that p63, a homologue of the cell-cycle regulator TP53, plays a critically important role in regulation of the formation and ..
  73. ncbi Comparison of 34betaE12 and P63 in 100 consecutive prostate carcinoma diagnosed by needle biopsies
    Howard Her Juing Wu
    Department of Pathology, Ball Memorial Hospital, Muncie, Indiana 47303, USA
    Appl Immunohistochem Mol Morphol 12:285-9. 2004
    b>P63, a homologue of p53, was recently identified as a useful basal cell-specific marker...
  74. ncbi [P63 protein in the diagnosis of breast tubular carcinoma]
    Jean Christophe Noel
    Service d Anatomie Pathologique, Clinique de Gynécopathologie et de Sénologie, Hopital Universitaire Erasme, Universite Libre de Bruxelles ULB, Route de Lennik 808, 1070 Bruxelles, Belgium
    Ann Pathol 24:319-23. 2004
    To study and compare the expression of p63 protein and smooth muscle actin in breast tubular carcinoma (TC) and its main differential diagnoses, radial scar (RS)/complex sclerosing lesion (CSL).
  75. ncbi Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast
    Mauro G Mastropasqua
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan, School of Medicine, Milan, Italy
    Mod Pathol 18:1277-82. 2005
    ..We evaluated the prevalence of c-kit, p63, and e-cadherin immunoreactivity in a series of 20 adenoid cystic carcinomas, comparing the results with those ..
  76. ncbi Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature
    M Varma
    Department of Pathology, University Hospital of Wales and School of Medicine, Cardiff, Wales, UK
    Histopathology 47:1-16. 2005
    ..advances in prostate cancer immunohistochemistry, including the introduction of newer basal cell markers such as p63 and the discovery of the overexpression of alpha-methylacyl coenzyme A racemase (AMACR) in prostate cancer...
  77. ncbi The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy
    Krista D Buono
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 293:565-80. 2006
    ..Hormonal stimulation of mutant tissue induced the expression of the basal cell transcription factor p63 in luminal cells and excessive proliferation of basal cells...
  78. ncbi Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2
    E Ferrante
    Institute of Endocrine Sciences, University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via Francesco Sforza 35, 20122 Milan, Italy
    Endocr Relat Cancer 13:955-62. 2006
    ..by the inhibitor orthovanadate, and independent from the induction of apoptosis-related genes, such as p53, p63, p73, Bcl-2, Bax, BID, BIK, TNFSF8, and FADD...
  79. ncbi Vitronectin supports migratory responses of corneal epithelial cells to substrate bound IGF-I and HGF, and facilitates serum-free cultivation
    S Louise Ainscough
    School of Life Sciences and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
    Exp Eye Res 83:1505-14. 2006
    ..Immunocytochemistry of resulting cultures for keratin 3 and p63 revealed a similar phenotype to those established under current best-practice conditions (i3T3, foetal bovine serum,..
  80. pmc A new E6/P63 pathway, together with a strong E7/E2F mitotic pathway, modulates the transcriptome in cervical cancer cells
    Sebastien Teissier
    Unité Expression Génétique et Maladies, CNRS FRE 2850, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 81:9368-76. 2007
    ..study, using new high-density microarrays containing more than 22,000 human cDNA sequences, we identified a novel p63 pathway among E2-activated genes and 38 new mitotic genes repressed by E2...
  81. ncbi Itch inhibition regulates chemosensitivity in vitro
    T M Hansen
    Medical Research Council, Toxicology Unit, Hodgkin Building, P O Box 138, Leicester University, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 361:33-6. 2007
    ..We have previously shown that p73 and p63, two members of the p53 family of tumour suppressors, are targets for Itch-mediated ubiquitylation and degradation...
  82. ncbi Regulation of DeltaNp63alpha by tumor necrosis factor-alpha in epithelial homeostasis
    Hae Ock Lee
    Department of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Korea
    FEBS J 274:6511-22. 2007
    A dominant negative form of p63, DeltaNp63alpha, is critical for maintaining the proliferative potential of epidermal stem cells and progenitor cells...
  83. pmc Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell
    Tetsuya Kawakita
    TissueTech, Inc, and Ocular Surface Center, Miami, FL 33173, USA
    J Cell Mol Med 12:1303-16. 2008
    ..Expanded cells were uniformly small, negative to K12 keratin, but positive for p63 nuclear staining, and could be subcultured beyond 100 passages...
  84. pmc Characterization of side population cells from human airway epithelium
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, Vancouver, British Columbia, Canada
    Stem Cells 26:2576-85. 2008
    ..All CD45(-) SP cells showed positive staining for epithelial-specific markers cytokeratin-5, E-cadherin, ZO-1, and p63. CD45(-) SP cells exhibited stable telomere length and increased colony-forming and proliferative potential, ..
  85. doi DeltaNp63 isoforms differentially regulate gene expression in squamous cell carcinoma: identification of Cox-2 as a novel p63 target
    Linda Boldrup
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    J Pathol 218:428-36. 2009
    The p53 homologue p63 produces six different isoforms that are important in development of epithelial tissues and squamous cell carcinoma of the head and neck (SCCHN)...
  86. doi Differential expression of p63 isoforms in normal skin and hyperproliferative conditions
    So Young Kim
    Department of Biochemistry, College of Medicine, Chung Ang University, Heukseok Dong, Dongjak Gu, Seoul, Korea
    J Cutan Pathol 36:825-30. 2009
    The p63 is regarded as a potential stem cell marker.
  87. doi Breast intracystic papillary carcinoma: an update
    Julien Calderaro
    Hopitaux de Paris AP HP, Hopital Saint Louis, Service de Pathologie, Paris, France
    Breast J 15:639-44. 2009
    ..In this study, surgical pieces of 20 IPCs were reassessed, and markers of myopepithelial layer (p63, CD10 and Smooth Muscle Actin) as well as estrogen receptors (ER) and progesterone receptors (PgR) and C-erb-B2 ..
  88. pmc Dual roles of Drosophila p53 in cell death and cell differentiation
    Y Fan
    Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cell Death Differ 17:912-21. 2010
    The mammalian p53 family consists of p53, p63 and p73. Whereas p53 accounts for tumor suppression through cell-cycle arrest and apoptosis, the functions of p63 and p73 are more diverse and also include control of cell differentiation...
  89. pmc Involvement of p63 in the herpes simplex virus-1-induced demise of corneal cells
    Laszlo Orosz
    Department of Medical Microbiology and Immunobiology, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    J Biomed Sci 17:47. 2010
    The transcription factor p63 plays a pivotal role in the development and maintenance of epithelial tissues, including the ocular surface...
  90. doi Myoepithelial carcinoma of the breast: a clinicopathological and immunohistochemical study of 15 diagnostically challenging cases
    Natalia Buza
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Virchows Arch 457:337-45. 2010
    ..Immunohistochemical stains for p63, CD10, CK903, and CK5/6 reacted strongly and diffusely with the tumor cells, and mainly the reactive stroma had ..
  91. doi Stem cell markers (cytokeratin 15, cytokeratin 19 and p63) in in situ and invasive cutaneous epithelial lesions
    Ossama Abbas
    Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, MA 02118, USA
    Mod Pathol 24:90-7. 2011
    ..However, most studies to date are restricted to the use of a single marker (p63, cytokeratin-15 or cytokeratin-19) and do not appear to compare distribution of stem cell markers in a spectrum of ..
  92. doi Value of human amniotic epithelial cells in tissue engineering for cornea
    Simat Siti Fatimah
    Department of Pathology Universiti Kebangsaan Malaysia, Kuala Lumpur
    Hum Cell 23:141-51. 2010
    ..After serial passage, CK3, CK19 and involucrin gene expressions were upregulated, while p63, CK1 and CK14 gene expressions were downregulated...
  93. pmc DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation
    Yingjuan Qian
    From the Comparative Oncology Laboratory, University of California, Davis, California 95616, USA
    J Biol Chem 286:12033-41. 2011
    The p63 gene, a member of the p53 family, is expressed as TA and ΔN isoforms. ΔNp63 is the predominant isoform expressed in cells of epithelial origin and frequently overexpressed in cancers...
  94. pmc Conditional ablation of the Notch2 receptor in the ocular lens
    Senthil S Saravanamuthu
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Dev Biol 362:219-29. 2012
    ..of Notch2, there were elevated levels of the cell cycle regulators Cdkn1a (p21Cip1), Ccnd2 (CyclinD2), and Trp63 (p63) that negatively regulates Wnt signaling, plus down-regulation of Cdh1 (E-Cadherin)...
  95. pmc MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction
    Ulf Andersson Ørom
    Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA, USA
    Cell Cycle 11:1291-5. 2012
    ..miR-203 is found to be highly induced by caloric restriction, and we demonstrate that caveolin-1 as well as p63 are direct targets of miR-203 in vivo during caloric restriction...
  96. pmc Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
    Cynthia R Coffill
    Quantitative Proteomics Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore
    EMBO Rep 13:638-44. 2012
    ..to heparin binding-epidermal growth factor-like growth factor that is p53R273H-dependant but does not require Rab coupling protein or p63. Advanced proteomics has thus allowed the detection of a new mechanism of p53-driven invasion.
  97. pmc HPV16 E5 and KGFR/FGFR2b interplay in differentiating epithelial cells
    Valeria Purpura
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Medicina Clinica e Molecolare, Sapienza Universita di Roma, Italy
    Oncotarget 4:192-205. 2013
    ..In addition, KGFR induced a ligand-dependent decrease of p63 through a miR-203 independent mechanism and this effect was blocked by inhibition of the PI3K/Akt signaling, which ..
  98. pmc Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis
    N S Chari
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Death Differ 20:1080-8. 2013
    ..Using in vivo murine models, we also provide evidence of GLI-mediated regulation of the TP63 pathway. p63 expression appears essential to establish an optimally functioning HH pathway...
  99. doi Aberrant expression of p63 in adenocarcinoma of the prostate: a radical prostatectomy study
    Giovanna A Giannico
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN Departments of Pathology Urology Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD
    Am J Surg Pathol 37:1401-6. 2013
    Prostatic adenocarcinoma with aberrant diffuse expression of p63 (p63-PCa) is a recently described variant of prostatic adenocarcinoma...
  100. doi The structure and development of Xenopus laevis cornea
    Wanzhou Hu
    UCL Institute of Ophthalmology, UCL, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Eye Res 116:109-28. 2013
    ..In the adult, a p63 positive limbus-like wavy structure is observed at the peripheral edge of the cornea...
  101. doi Adenosquamous proliferation of the breast and low grade adenosquamous carcinoma: a common precursor of an uncommon cancer?
    Mark James Wilsher
    Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia
    Pathology 46:402-10. 2014
    ..RSLs that displayed foci of ASP were further examined with immunohistochemical markers for p63, calponin, cytokeratin 5/6, oestrogen and progesterone receptors...

Research Grants64

  1. Luis Alfonso Martinez; Fiscal Year: 2016
    ..the first involves the physical inactivation of other tumor suppressor proteins such as its family members, p63 and p73, and the other is dependent on its ability to regulate gene expression...
  2. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): P63 is a member of the p53 family. When the upstream promoter is used for p63 expression, three major TAp63 isoforms, TAp63a, TAp63[unreadable], and TAp63?, are produced...
  3. Satrajit Sinha; Fiscal Year: 2014
    ..This is epitomized by the striking phenotype of the p63 knockout mice, which lack a mature stratified epidermis and exhibit a block in development of multiple ectodermal ..
  4. Cellular and molecular biology of lung surfactant
    Aron B Fisher; Fiscal Year: 2013
    ..This project provides novel information on P63 as a biologically-relevant SP-A receptor...
  5. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
    ....
  6. Xinbin Chen; Fiscal Year: 2015
    ..tumor burdens and metastasis rates, which are compounded in mice harboring heterozygous alleles of p53 and/or p63. However, p73 is not a classic tumor suppressor since mutant mice are also prone to developmental defects, chronic ..
  7. Guy Howard; Fiscal Year: 2015
    ..Data shows that p63, a member of the p53 family of transcription factors, plays a major role in the cooperative actions of HGF and 1,..
  8. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2010
    ..We have recently demonstrated that the transcription factor p63 is the molecular switch for initiation of the epidermal stratification program...
  9. Takeshi Kurita; Fiscal Year: 2014
    ..demonstrated that developmental exposure to DES induces cervical/vaginal adenosis by disrupting expression of p63 transcription factor, which is essential for development of squamous epithelia...
  10. Rose Anne Romano; Fiscal Year: 2015
    ..sequencing data emerging from the Cancer Genome Atlas Project, strongly suggest that the transcription factor p63, specifically the most prevalent Np63 isoforms, function as an oncogene in the early stages of SCC development...
  11. Maranke I Koster; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The p63 gene encodes several transcription factors that are required for normal development and homeostasis of the skin and its appendages...
  12. KEVIN MATTHEW CURTIS; Fiscal Year: 2015
    ..During murine development, the transcription factor p63 is required for skeletal formation, and our recent work demonstrated that p63 is integral for hepatocyte growth ..
  13. Carol Prives; Fiscal Year: 2015
    ..an interdisciplinary and collaborative approach to understand the roles of mutant p53, p53 family member's p63 and p73 and new tumor suppressor genes in cancer...
  14. James E Schwob; Fiscal Year: 2016
    ..Recently, we have shown that the transcription factor p63 is key to HBC differentiation and regeneration...
  15. JOHN J NGAI; Fiscal Year: 2015
    ..In this application we propose to investigate the role of the transcription factor p63 - a member of the p53 family of tumor suppressors - in olfactory stem cell regulation...
  16. Novel Genetic Approach To Isolate Stem Cells Of The Oral Cavity
    Satrajit Sinha; Fiscal Year: 2012
    ..Recent studies have offered compelling evidence in support of the transcription factor p63, particularly the ?Np63 isoform, to be highly expressed in the stem cell compartment of the stratified squamous ..
  17. Olfactory Epithelial Stem Cell Regulation by the Transcription Factor p63
    Nikolai Schnittke; Fiscal Year: 2013
    ..The transcription factor p63, a member of the p53 family, is necessary for the embryonic appearance of HBCs and loss of p63 expression in the ..
  18. Functional analysis of the p53 tumor suppressor
    Moshe Oren; Fiscal Year: 2012
    ..genes in a manner leading to transcriptional silencing, explore the possibility that dominant negative forms of p63, a p53 family member, are responsible for the failure of p53 to function as an effective tumor suppressor in some ..
  19. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
    ..Specific tumor suppressor genes, including p14 and p16, and proto-oncogenes, including p63, have been identified as critical in oral cancer development...
  20. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..comprising endocervical, ectocervical and vaginal epithelial cells with special focus on stable gene transfer into p63+CK17+epithelial stem cells which are capable of renewing stratified epithelium...
  21. Alexander I Zaika; Fiscal Year: 2016
    ..p53 protein has been relatively well characterized, less is known about other members of the p53 family, p73 and p63. Accumulating evidence suggest that p73 and p63 significantly affect the p53 activity and function in concert with ..
  22. ANIL KUMAR JAISWAL; Fiscal Year: 2015
    ..that NQO1 and NQO2 stabilization of tumor suppressor p53 against 20S proteasome degradation and down regulation of p63 and MAPK pathway contributed to carcinogenesis...
  23. John C Schimenti; Fiscal Year: 2016
    ..We also found that both programmed and induced DSBs trigger CHK2-dependent phosphorylation of p63 (TRP63) in diplotene oocytes...
  24. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2012
    ..Furthermore, EGFR TKIs induce PUMA through the effects on the p53 family members p63 and p73, but not p53 itself...
  25. Madhavi P Kadakia; Fiscal Year: 2016
    ..We have previously shown that VDR is positively regulated by the most abundant and physiologically relevant p63 isoform, [unreadable]Np63a...
  26. The role of p63 and p73 in cancer
    UTE MARTHA MOLL; Fiscal Year: 2012
    Title: the Role of p63 and p73 in Cancer PI: Ute M. Moll, M.D. Abstract p53 controls a powerful stress response and is a quintessential tumor suppressor...
  27. Jennifer A Pietenpol; Fiscal Year: 2014
    Although the pivotal role of p53 in tumor suppression remains unchallenged, the role of its family members, p63 and p73 in normal cell function and tumorigenesis is far from certain...
  28. Osteosarcoma Translational Research
    Qiping Zheng; Fiscal Year: 2013
    ..data from the principal investigator's group have shown that transgenic mice overexpressing Runx2 or P63 in hypertrophic chondrocytes result in delayed or accelerate chondrocyte maturation respectively...
  29. Sheida Nabavi; Fiscal Year: 2014
    ..The recent discovery of the p63/p73 expression, p53 mutation and measurements of DNA repair status effects on the sensitivity to cisplatin in TNBC ..
  30. Elsa R Flores; Fiscal Year: 2015
    ..The functions of p63, a p53 family member, are beginning to be understood in contexts in which p53 function has been well established, ..
  31. p63-Dependent Checkpoints in Oocytes
    Frank D McKeon; Fiscal Year: 2010
    ..How DNA damage triggers the death of these arrested oocytes is poorly understood but we now know that p63, a homolog of the p53 tumor suppressor, is highly expressed in these oocytes and plays an essential role in their ..
  32. Mechanisms of Delta-N-p63-alpha transcriptional repression and its role in squamo
    CORRIE LYNN GALLANT-BEHM; Fiscal Year: 2013
    ....
  33. Leif W Ellisen; Fiscal Year: 2015
    ..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
  34. Sabina Signoretti; Fiscal Year: 2014
    ..The p63 gene is selectively expressed in basal cells of various epithelia and is required for epithelial development...
  35. Role of p53 homologs in DNA repair in human keratinocytes
    Dennis H Oh; Fiscal Year: 2013
    ..current award period has documented that keratinocytes require loss of both p53 and another member of the family-p63-before repair is compromised...
  36. A novel mouse prostate carcinogenesis model for dietary cancer prevention researc
    Chung S Yang; Fiscal Year: 2013
    ..NF-kB and CD45), and oxidative stress (8-OHdG and -H2AX), as well as the expression of GSTP1, E-cadherin, COX-2, p63, p27, Pten, Nkx3.1, p16, and Bcl-2 by immunohistochemistry (IHC)...
  37. Xinbin Chen; Fiscal Year: 2016
    ..e., p63 and p73), which would then enhance gain of function for these p53 mutants...
  38. Laimonis A Laimins; Fiscal Year: 2014
    ..Additional important activities identified for E6 include blocking of p300 acetylation of p53 and activation of p63 upon differentiation...
  39. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..leukemia in the soft-shell clam, Mya arenaria, in which clam homologs that we have identified for human p53 and p63/73 proteins are rendered non-functional by their sequestration in the cytoplasm of leukemic clam hemocytes...
  40. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..comprising endocervical, ectocervical and vaginal epithelial cells with special focus on stable gene transfer into p63+CK17+epithelial stem cells which are capable of renewing stratified epithelium...
  41. Cytokines Stimulate Prostate Epithelial Proliferation
    Wade Bushman; Fiscal Year: 2009
    ..and demonstrate that these inflammatory mediators promote epithelial growth and a selective expansion of p63+ epithelial cells...
  42. Role of DN-p63 in Preservation of Self Renewal
    James DiRenzo; Fiscal Year: 2009
    ..objective of this proposal is to test the hypothesis that factors, which promote the expression or activity of DN-p63 contribute to the preservation of self-renewal in basal epithelia, and factors that oppose the expression or ..
  43. LEISHMANIA AND HOST DEFENSE
    PAUL EDELSON; Fiscal Year: 1991
    ..We have also shown that the parasite surface protease p63 can modify the form of C3 on the surface of the parasite and in this way change the receptor to which the parasite ..
  44. MOLECULAR REGULATION OF SIGNALING BY IONIZING RADIATION
    Donald Kufe; Fiscal Year: 2002
    ..The proposed studies will also address a model in which p63, a third member of the p53 family, is subject to IR-induced regulation by the Lyn/c-Abl complex...
  45. Regulation of p53 in reespnse to genotoxic stress
    Zhi xiong Xiao; Fiscal Year: 2006
    ..molecular approach to investigate the mechanism(s) by which Pinl modulates p53 and the p53 family member, p63. In addition, we will examine the role of Pinl-mediated modulation of p53 in chemotherapy of breast cancer using an ..
  46. Defining Cell Lineages in the Bladder Urothelium
    Sabina Signoretti; Fiscal Year: 2006
    ..We have recently demonstrated that the p53-homologue p63 is required for the development of basal and intermediate cells of the urothelium...
  47. Role of the p53/p63 Target Gene Perp in Mammary Gland Morphogenesis and Cancer
    RACHEL DUSEK; Fiscal Year: 2007
    ..Perp, a novel tetraspan membrane protein regulated by the p53 and p63 transcription factors, is known a known effector of apoptosis and cell-cell adhesion and is likely to be important ..
  48. P63 IN EPITHELIAL CELL PROLIFERATION AND DIFFERENTIATION
    Frank McKeon; Fiscal Year: 2004
    p53 is the most commonly mutated gene in human cancers. Recently, two related genes, p73 and p63, have been described which are capable of transactivation and cell-death inducing activities typically associated with the p53 tumor ..
  49. P63 Network in Pathogenesis of Ectodermal Dysplasia
    Alexey Fomenkov; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): We hypothesize that p63 functions through physical and functional interaction with other cellular proteins contributing in regulation of cell proliferation, differentiation and ..
  50. Molecular Mechanisms of Skin and Appendage Development
    DENNIS ROOP; Fiscal Year: 2005
    ..5 in the mouse, which is prior to epidermal stratification and appendage formation. In the absence of p63, the epidermis does not develop past an undifferentiated single-layered epithelium, which lacks appendages...
  51. Salivary Acinar Cell Apoptosis: Regulation of p53 by Akt
    KIRSTEN LIMESAND; Fiscal Year: 2009
    ..The identification of two p53 homologues, p73 and p63, along with the selective activation of apoptotic target genes by these different homologues have added additional ..
  52. International Research Conference on AEC Syndrome
    Alanna Bree; Fiscal Year: 2006
    ..AEC is a potentially life threatening autosomal dominant syndrome caused by mutations in the p63 gene...
  53. The role of s-SHIP in normal and tumorigenic development of the skin
    LARRY ROHRSCHNEIDER; Fiscal Year: 2007
    ..Furthermore we will study the regulation of the sSHIP promoter by the p63 transcription factor. Work from this proposal will aid in the better understanding of the development of the skin...
  54. The Role of P40 in Squamous Cell Carcinomas
    David Sidransky; Fiscal Year: 2009
    We previously cloned p63, a p53 family member, and subsequently investigated its role in cancer...
  55. Elucidate the role of p63 in prostate cancer progression
    Madhavi Kadakia; Fiscal Year: 2007
    ..The p63 gene, a member of the p53 tumor suppressor gene family, plays a critical role in prostate development...
  56. Molecular Dissection of a Novel P53-like Protein
    Hua Lu; Fiscal Year: 2006
    ..The principal investigator has purified and identified NBP as the recently cloned p53 homolog p63 from Hela nuclear extracts...
  57. PATHWAY LEADS TO APOPTOSIS IN SRC TRANSFORMED CELLS
    HWA CHAIN WANG; Fiscal Year: 2002
    ..I have detected a novel serine/threonine protein kinase, p63 SAMK (src activated MBP kinase) whose activation may be involved in the process of apoptosis in normal and ..
  58. Role of Tumor Suppressor p53 in Breast Cancer
    Mariano Scian; Fiscal Year: 2004
    ..can be partially explained by mutant p53's interaction with and consequent inactivation of p53-homologue p73 and p63, as evident by changes in the expression profile of genes regulated by p73 and p63...
  59. Pharmacological rescue of mutant p53 function
    Jiandong Chen; Fiscal Year: 2007
    ..expression in a mutant p53-dependent manner and has no effects on the activity of wild type p53 or p53 homologs p63 and p73. Ellipticine treatment alters mutant p53 conformation and sensitivity to protease digestion...
  60. International Mdm2 Workshop IV
    Stephen Jones; Fiscal Year: 2007
    ..In addition, MDM regulation of proteins other than p53 (including p73/p63) during cell growth is discussed, as are other modifiers of the p53 tumor suppressor pathway that exert their ..
  61. Growth Arrest in Differentiating Keratinocytes
    Deepak Agrawal; Fiscal Year: 2005
    ..Additional investigations will determine the role of the p53 homolog p63 in cyclin G2 induction...
  62. MURINE P73 IN TUMORIGENESIS
    Frank McKeon; Fiscal Year: 2007
    ..apparently contradictory transactivating and dominant negative p73 isotypes for tumorigenesis? (3) Are the p73 and p63 genes interacting with, or required by, p53 in cellular damage response pathways, and can we model these ..