CIAO1

Summary

Gene Symbol: CIAO1
Description: cytosolic iron-sulfur assembly component 1
Alias: CIA1, WDR39, WD repeat domain 39, WD repeat-containing protein 39, WD40 protein Ciao1, cytosolic iron-sulfur protein assembly 1 homolog
Species: human

Top Publications

  1. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
  2. pmc Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins
    Oliver Stehling
    Institut fur Zytobiologie, Philipps Universitat Marburg, Robert Koch Strasse, Germany
    Cell Metab 18:187-98. 2013
  3. doi MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism
    Kerstin Gari
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
    Science 337:243-5. 2012
  4. doi MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation
    Shinsuke Ito
    Human Cell Biology Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Mol Cell 39:632-40. 2010
  5. ncbi Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1
    R W Johnstone
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:10880-7. 1998
  6. pmc A Glutaredoxin-BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery
    Avery G Frey
    NIDDK, NIH, United States
    J Biol Chem . 2016
  7. pmc Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19
    Tatiana N Moiseeva
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Suite 2 6, 5117 Centre Avenue, Pittsburgh, PA 15213 1863, USA
    DNA Repair (Amst) 43:9-17. 2016
  8. pmc The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway
    Ajay A Vashisht
    From the Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095
    J Biol Chem 290:14218-25. 2015
  9. doi Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity
    Arunkumar S Upadhyay
    Department of Clinical Microbiology, Virology, Umea University, SE 901 85, Umea, Sweden
    Cell Microbiol 16:834-48. 2014
  10. pmc Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs
    Ifat Lev
    Faculty of life sciences Bar Ilan University, Ramat Gan, Israel
    PLoS Genet 9:e1003838. 2013

Research Grants

  1. JAMES AKIRA WOHLSCHLEGEL; Fiscal Year: 2016

Scientific Experts

  • Lin Wang
  • R A McIndoe
  • Roland Lill
  • JAMES AKIRA WOHLSCHLEGEL
  • Daili J A Netz
  • Antonio J Pierik
  • Ajay A Vashisht
  • Takashi Umehara
  • Oliver Stehling
  • Mineaki Seki
  • Avery G Frey
  • Tatiana N Moiseeva
  • Janneke Balk
  • Arunkumar S Upadhyay
  • James A Wohlschlegel
  • Anastasios D Tsaousis
  • Masami Horikoshi
  • Ifat Lev
  • Christian Rosar
  • Kerstin Gari
  • Kai En Chen
  • Scott M Langevin
  • Niek van Wietmarschen
  • Dexian Luo
  • Kiyoji Tanaka
  • Hirohito Endo
  • Judita Mascarenhas
  • Shinsuke Ito
  • Martin Stümpfig
  • Ali D Malay
  • A Ritala
  • Max Brenner
  • M M Griffiths
  • Yumi Nakai
  • Vasundara Srinivasan
  • Shigeyuki Yokoyama
  • Balasundaram Padmanabhan
  • Leigh Ann Higa
  • E F Remmers
  • Wei Fon Hung
  • Hideki Bo
  • Caroline C Philpott
  • Y Kawahito
  • Brian L Hood
  • Armin M Gamper
  • Christopher J Bakkenist
  • Justin D Wildemann
  • Daniel J Palenchar
  • Thomas P Conrads
  • J Wang
  • Tanu Sharma
  • Kevin Ro
  • Clarissa C Yu
  • Eleni Gentekaki
  • Daniel Gaston
  • Andrew J Roger
  • G W Cannon
  • Kirstin Vonderstein
  • Gerhard Dobler
  • Ju Tao Guo
  • Keiryn L Bennett
  • Anna K Overby
  • Friedemann Weber
  • R L Wilder
  • Andreas Pichlmair
  • Giulio Superti-Furga
  • Laura Eme
  • Brigitte Niggemeyer
  • Nelly Levinton
  • Liach Emuna
  • Liron Goor
  • Kazuhiro Iwai
  • Alex D Sheftel
  • Marina Volpe
  • Shay Ben-Aroya
  • Ralf Rösser
  • Yukiko Takeda
  • Ayanthi A Richards
  • Annie Moradian
  • Andreas P M Weber
  • J Mark Skehel
  • Ian L Ross
  • Heather H Nelson
  • John K Wiencke
  • Delphine G Bernard
  • Arun M Nanda
  • William E Walden
  • Simon J Boulton
  • Brock C Christensen
  • Anil K Sharma

Detail Information

Publications35

  1. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  2. pmc Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins
    Oliver Stehling
    Institut fur Zytobiologie, Philipps Universitat Marburg, Robert Koch Strasse, Germany
    Cell Metab 18:187-98. 2013
    ..Here, we identify and characterize human CIA2A (FAM96A), CIA2B (FAM96B), and CIA1 (CIAO1) as components of the cytosolic Fe/S protein assembly (CIA) machinery...
  3. doi MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism
    Kerstin Gari
    DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms EN6 3LD, UK
    Science 337:243-5. 2012
    ..Here, we demonstrate that MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1, and MIP18. Cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism...
  4. doi MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation
    Shinsuke Ito
    Human Cell Biology Group, Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Mol Cell 39:632-40. 2010
    ..Instead, it included FAM96B (now designated MIP18), Ciao1, and ANT2. MMS19, MIP18, and XPD localized to the mitotic spindle during mitosis...
  5. ncbi Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1
    R W Johnstone
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:10880-7. 1998
    ..Thus, Ciao 1 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation...
  6. pmc A Glutaredoxin-BolA Complex Serves as an Iron-Sulfur Cluster Chaperone for the Cytosolic Cluster Assembly Machinery
    Avery G Frey
    NIDDK, NIH, United States
    J Biol Chem . 2016
    ..Fe-S coordination by Glrx3-BolA2 did not depend on Ciapin1 or Ciao1, proteins that bind Glrx3 and are involved in cytosolic Fe-S cluster assembly and distribution...
  7. pmc Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19
    Tatiana N Moiseeva
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, Hillman Cancer Center, Research Pavilion, Suite 2 6, 5117 Centre Avenue, Pittsburgh, PA 15213 1863, USA
    DNA Repair (Amst) 43:9-17. 2016
    ..We also describe novel interactions between POLE1 and the iron-sulfur cluster assembly complex CIA proteins CIAO1 and MMS19...
  8. pmc The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway
    Ajay A Vashisht
    From the Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, California 90095
    J Biol Chem 290:14218-25. 2015
    ..We recently identified a cytoplasmic Fe-S cluster assembly (CIA) targeting complex composed of MMS19, CIAO1, and FAM96B that is required for the biogenesis of extramitochondrial Fe-S proteins including XPD...
  9. doi Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity
    Arunkumar S Upadhyay
    Department of Clinical Microbiology, Virology, Umea University, SE 901 85, Umea, Sweden
    Cell Microbiol 16:834-48. 2014
    ..ER localization for full antiviral activity and to interact with the cytosolic Fe/S protein assembly factor CIAO1. Radiolabelling in vivo revealed incorporation of (55) Fe, indicative for the presence of an Fe-S cluster...
  10. pmc Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs
    Ifat Lev
    Faculty of life sciences Bar Ilan University, Ramat Gan, Israel
    PLoS Genet 9:e1003838. 2013
    ..This method will facilitate the study of protein structure-function relationships, and may help in elucidating the mechanisms that regulate PPIs. ..
  11. pmc Evolution of the cytosolic iron-sulfur cluster assembly machinery in Blastocystis species and other microbial eukaryotes
    Anastasios D Tsaousis
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, Department of Biochemistry and Molecular Biology, Halifax, Nova Scotia, Canada
    Eukaryot Cell 13:143-53. 2014
    ..strain NandII. We identified transcripts encoding six of the components-Cia1, Cia2, MMS19, Nbp35, Nar1, and a putative Tah18-and showed using immunofluorescence microscopy, immunoelectron ..
  12. ncbi Inhibited PTHLH downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by sy
    Lin Wang
    Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China
    Integr Biol (Camb) 4:1256-62. 2012
    ..coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, ALK, CIAO1, NOTCH3 in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference ..
  13. ncbi Polyanionic stretch-deleted histone chaperone cia1/Asf1p is functional both in vivo and in vitro
    Takashi Umehara
    Laboratory of Developmental Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 7:59-73. 2002
    ..cerevisiae Asf1p, but not in human CIA. We investigated how CIA/Asf1p utilizes its domain(s) for the alteration of nucleosomal structure...
  14. pmc IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway
    Mineaki Seki
    Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 288:16680-9. 2013
    ..The roles of each component are also largely unknown. Here, we show that MMS19, MIP18, and CIAO1 form a tight "core" complex and that IOP1 is an "external" component of this complex...
  15. pmc The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly
    Niek van Wietmarschen
    European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biol Chem 287:43351-8. 2012
    ..repair protein homolog MMS19 can simultaneously bind probable cytosolic iron-sulfur protein assembly protein CIAO1 and Fe-S proteins, confirming that MMS19 is a central protein of the CIA machinery that brings Fe-S cluster donor ..
  16. pmc A bridging [4Fe-4S] cluster and nucleotide binding are essential for function of the Cfd1-Nbp35 complex as a scaffold in iron-sulfur protein maturation
    Daili J A Netz
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Strasse 6, 35032 Marburg, Germany
    J Biol Chem 287:12365-78. 2012
    ..the C-terminal Fe-S cluster may be ideal for its facile assembly, labile binding, and efficient transfer to target Fe-S apoproteins, a step facilitated by the cytosolic iron-sulfur (Fe-S) protein assembly proteins Nar1 and Cia1 in vivo.
  17. pmc Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study
    Scott M Langevin
    Department of Epidemiology, Brown University, Providence, RI, USA
    Epigenetics 7:291-9. 2012
    ..and controls were best differentiated by a methylation profile of six CpG loci (associated with FGD4, SERPINF1, WDR39, IL27, HYAL2 and PLEKHA6), with an AUC of 0.73 (95% CI: 0.62-0.82)...
  18. doi The leaf reticulate mutant dov1 is impaired in the first step of purine metabolism
    Christian Rosar
    Institute for Plant Biochemistry, Heinrich Heine Universitat, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Mol Plant 5:1227-41. 2012
    ..dov1 is allelic to the previously characterized cia1-2 mutant that was isolated in a screen for mutants with impaired chloroplast protein import...
  19. pmc The DUF59 family gene AE7 acts in the cytosolic iron-sulfur cluster assembly pathway to maintain nuclear genome integrity in Arabidopsis
    Dexian Luo
    National Laboratory of Plant Molecular Genetics and Centre for Plant Gene Research Shanghai, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Plant Cell 24:4135-48. 2012
    ..AE7 is part of a protein complex with CIA1, NAR1, and MET18, which are highly conserved in eukaryotes and are involved in the biogenesis of cytosolic and ..
  20. doi The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer
    Kai En Chen
    Institute for Molecular Bioscience, Division of Chemistry and Structural Biology, University of Queensland, Brisbane, Queensland 4072, Australia
    Acta Crystallogr D Biol Crystallogr 68:637-48. 2012
    ..site of bacterial DUF59 proteins is not conserved in Fam96a, but Fam96a interacts tightly in vitro with Ciao1, the cytosolic iron-assembly protein...
  21. pmc Characterization of Arabidopsis glutamine phosphoribosyl pyrophosphate amidotransferase-deficient mutants
    Wei Fon Hung
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Plant Physiol 135:1314-23. 2004
    ..Positional cloning of one of the loci, CIA1, revealed that CIA1 encodes Gln phosphoribosyl pyrophosphate amidotransferase 2 (ATase2), one of the three ATase ..
  22. ncbi A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Genet 14:82-5. 1996
    ..Not surprisingly, we identified a major susceptibility factor, Cia1, on chromosome 20 in the vicinity of the rat major histocompatibility complex (MHC)...
  23. ncbi Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases
    Y Kawahito
    The Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 1820, USA
    J Immunol 161:4411-9. 1998
    ..We found two quantitative trait loci (QTLs) in common, i.e., Aia1/Cia1 on chromosome 20, which includes the MHC, and Aia3/Cia3 on chromosome 4...
  24. pmc Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice
    R A McIndoe
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:2210-4. 1999
    ..One susceptibility locus, Cia1 in the major histocompatibility locus, had been identified previously...
  25. ncbi Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis
    Hideki Bo
    Department of Molecular Pathology, Institute of Gerontology, Nippon Medical School
    J Nippon Med Sch 71:172-80. 2004
    ..GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6. Several of these genes were novel and not previously known to be associated with irradiation...
  26. pmc Purification, crystallization and preliminary X-ray diffraction analysis of the histone chaperone cia1 from fission yeast
    Takashi Umehara
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro, Tsurumi, Yokohama 230 0045, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:971-3. 2005
    In fission yeast, cia1+ is an essential gene that encodes a histone chaperone, a homologue of human CIA (CCG1-interacting factor A) and budding yeast Asf1p (anti-silencing function-1), which both facilitate nucleosome assembly by ..
  27. pmc The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly
    Janneke Balk
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Germany
    Mol Cell Biol 25:10833-41. 2005
    ..Here, we have identified and functionally characterized a novel WD40 repeat protein, designated Cia1, as an essential component required for Fe/S cluster assembly in vivo on cytosolic and nuclear, but not ..
  28. doi Chromatin dynamics mediated by histone modifiers and histone chaperones in postreplicative recombination
    Hirohito Endo
    Tohoku University, Aramaki, Aoba ku, Sendai, Miyagi, Japan
    Genes Cells 15:945-58. 2010
    ..Here, histone H3 Lys56 acetylation, mediated by the histone acetyltransferase Rtt109 and the histone chaperone Cia1/Asf1, is shown to be required for postreplicative sister chromatid recombination...
  29. doi Production of a recombinant industrial protein using barley cell cultures
    A Ritala
    VTT Technical Research Centre of Finland, P O Box 1000, 02044 Espoo, VTT, Finland
    Protein Expr Purif 59:274-81. 2008
    ..For this study the human Collagen I alpha 1 (CIa1) chain gene encoding the complete helical region of CIa1 optimized for monocot expression was fused to its N- and C-..
  30. doi Crystal structures of fission yeast histone chaperone Asf1 complexed with the Hip1 B-domain or the Cac2 C terminus
    Ali D Malay
    Yokohama Institute, RIKEN, Tsurumi, Yokohama 230 0045, Japan
    J Biol Chem 283:14022-31. 2008
    ..Here we report the crystal structures of the apo-form of fission yeast Asf1/Cia1 (SpAsf1N; residues 1-161) as well as its complexes with the B-domain of the fission yeast HIRA orthologue Hip1 (..
  31. ncbi Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis
    Vasundara Srinivasan
    Department of Molecular Membrane Biology, Max Planck Institute for Biophysics, Max von Laue Str 3, D 60438 Frankfurt M, Germany
    Structure 15:1246-57. 2007
    ..Human Ciao1, which reportedly interacts with the Wilms' tumor suppressor, WT1, is structurally similar to yeast Cia1...
  32. pmc Genetic regulation of T regulatory, CD4, and CD8 cell numbers by the arthritis severity loci Cia5a, Cia5d, and the MHC/Cia1 in the rat
    Max Brenner
    Laboratory of Experimental Rheumatology, The Robert S Boas Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 13:277-87. 2007
    ..DA(Cia1), DA.F344(Cia5a), and DA.F344(Cia5d) rats congenic for arthritis QTL...
  33. ncbi The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol
    Daili J A Netz
    Institut fur Zytobiologie, Philipps Universitat Marburg, Robert Koch Strasse 6, D 35033 Marburg, Germany
    Nat Chem Biol 3:278-86. 2007
    ..So far, four highly conserved proteins (Cfd1, Nbp35, Nar1 and Cia1) have been identified as members of the cytosolic [Fe-S] protein assembly machinery, but their molecular function ..
  34. pmc Thio modification of yeast cytosolic tRNA is an iron-sulfur protein-dependent pathway
    Yumi Nakai
    Department of Biochemistry, Osaka Medical College, 2 7 Daigakumachi, Takatsuki 569 8686, Japan
    Mol Cell Biol 27:2841-7. 2007
    ..We demonstrate here that the three CIA components, Cfd1, Nbp35, and Cia1, are required for the 2-thio modification of cy-tRNAs but not of mt-tRNAs...
  35. ncbi CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
    Leigh Ann Higa
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Cell Biol 8:1277-83. 2006
    ..Our studies suggest that CUL4-DDB1 ligases use WDR proteins as molecular adaptors for substrate recognition, and modulate multiple biological processes through ubiquitin-dependent proteolysis...

Research Grants1

  1. JAMES AKIRA WOHLSCHLEGEL; Fiscal Year: 2016
    ..aim 3 will focus on the establishing the functional relevance of the interaction between FBXL5 and MMS19 and CIAO1, two putative components of the cytosolic iron assembly (CIA) pathway which is required for the assembly of Fe/S ..