CI-MPR

Summary

Gene Symbol: CI-MPR
Description: insulin like growth factor 2 receptor
Alias: CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI, cation-independent mannose-6-phosphate receptor, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, IGF-II receptor, M6P/IGF2 receptor, insulin-like growth factor II receptor
Species: human

Top Publications

  1. ncbi The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans
    V M Kalscheuer
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Nat Genet 5:74-8. 1993
  2. ncbi PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
    L Wan
    Vollum Institute, The Oregon Health Sciences University, Portland 97201, USA
    Cell 94:205-16. 1998
  3. ncbi Insulin-like growth factor II receptor as a multifunctional binding protein
    D O Morgan
    Nature 329:301-7. 1987
  4. ncbi M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    A T De Souza
    Department of Safety of Medicines, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK
    Nat Genet 11:447-9. 1995
  5. ncbi Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
    A T De Souza
    Department of Safety of Medicines, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK
    Oncogene 10:1725-9. 1995
  6. ncbi TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking
    E Diaz
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 93:433-43. 1998
  7. pmc Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
    H Ikushima
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:8439-44. 2000
  8. ncbi Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
    B Motyka
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Cell 103:491-500. 2000
  9. pmc PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic
    C M Crump
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    EMBO J 20:2191-201. 2001
  10. ncbi Role of Rab9 GTPase in facilitating receptor recruitment by TIP47
    K S Carroll
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Science 292:1373-6. 2001

Research Grants

  1. Nancy M Dahms; Fiscal Year: 2016
  2. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2004
  3. Roles of Retromer Complex in Development
    Xinhua Lin; Fiscal Year: 2013
  4. Dwight D Koeberl; Fiscal Year: 2014
  5. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
  6. Igf2r Tumor Suppression in Igf2 and TGFa Transgenic Mice
    DIMITRINA PRAVTCHEVA; Fiscal Year: 2004
  7. Insulin-like growth factor 2 receptor in CNS viral infection and inflammation
    Hyeon Sook Suh; Fiscal Year: 2012
  8. ANGELA GELLI; Fiscal Year: 2014
  9. Dissecting the innate immune response mediated by Arabidopsis Nudix hydrolase
    Yiji Xia; Fiscal Year: 2010
  10. TRANSPORT OF PESTICIDES MEDIATED BY MRP1 AND MRP3
    Lisa Bain; Fiscal Year: 2000

Detail Information

Publications288 found, 100 shown here

  1. ncbi The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans
    V M Kalscheuer
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Nat Genet 5:74-8. 1993
    ..The human IGF2R gene, another classic example of imprinting in mice, was found to be expressed from both alleles. We provide the first direct evidence for differential imprinting in the human and murine genome...
  2. ncbi PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization
    L Wan
    Vollum Institute, The Oregon Health Sciences University, Portland 97201, USA
    Cell 94:205-16. 1998
    ..Cell-free assays indicate TGN localization of furin is directed by a PACS-1-mediated retrieval step. Together, these findings explain a mechanism by which membrane proteins in mammalian cells are localized to the TGN...
  3. ncbi Insulin-like growth factor II receptor as a multifunctional binding protein
    D O Morgan
    Nature 329:301-7. 1987
    ..The structural and biochemical features of the IGF-II receptor appear identical to those of the cation-independent mannose-6-phosphate receptor...
  4. ncbi M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity
    A T De Souza
    Department of Safety of Medicines, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK
    Nat Genet 11:447-9. 1995
    ..These mutations give rise to truncated receptor protein and significant amino acid substitutions, and provide evidence that the M6P/IGF2R gene functions as a tumour suppressor in human liver carcinogenesis...
  5. ncbi Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
    A T De Souza
    Department of Safety of Medicines, Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK
    Oncogene 10:1725-9. 1995
    ..These results support the hypothesis that the M6P/IGFIIr gene may function as a tumor suppressor gene in the liver...
  6. ncbi TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking
    E Diaz
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 93:433-43. 1998
    ..These data suggest that TIP47 binds MPR cytoplasmic domains and facilitates their collection into transport vesicles destined for the Golgi...
  7. pmc Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
    H Ikushima
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:8439-44. 2000
    ....
  8. ncbi Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
    B Motyka
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Cell 103:491-500. 2000
    ..These results suggest a novel target for immunotherapy and a potential mechanism used by tumors for immune evasion...
  9. pmc PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic
    C M Crump
    Vollum Institute, L 474, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    EMBO J 20:2191-201. 2001
    ..These studies demonstrate the requirement for PACS-1 interactions with adaptor proteins in multiple processes, including secretory granule biogenesis and HIV-1 pathogenesis...
  10. ncbi Role of Rab9 GTPase in facilitating receptor recruitment by TIP47
    K S Carroll
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Science 292:1373-6. 2001
    ..Thus, a cytosolic cargo selection device may be selectively recruited onto a specific organelle, and vesicle budding might be coupled to the presence of an active Rab GTPase...
  11. ncbi Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains
    Saurav Misra
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:933-7. 2002
    ..The rigid spatial alignment of the three binding subsites leads to high specificity...
  12. ncbi Structural basis for recognition of acidic-cluster dileucine sequence by GGA1
    Tomoo Shiba
    Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization KEK, Tsukuba, Ibaraki 305 0801, Japan
    Nature 415:937-41. 2002
    ..This recognition mechanism provides the basis for regulation of protein transport from the TGN to endosomes/lysosomes, which is shared by sortilin and low-density lipoprotein receptor-related protein...
  13. pmc Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, England, UK
    J Cell Biol 165:111-22. 2004
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin...
  14. ncbi Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth
    K Kaku
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba, Japan
    Acta Paediatr 96:363-7. 2007
    ..The aim of this study was to investigate the associations between the neonatal birth weight and the genotypes of polymorphic loci in the IGF2 and IGF2 receptor (IGF2R) genes...
  15. pmc Structure and functional analysis of the IGF-II/IGF2R interaction
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK
    EMBO J 27:265-76. 2008
    ..Mutagenesis analyses confirm this IGF-II 'binding-hotspot', revealing that IGF-binding proteins and IGF2R have converged on the same high-affinity site...
  16. doi IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells
    Chun Hsien Chu
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan, ROC
    J Endocrinol 197:381-90. 2008
    ..The suppression of IGF2R signaling pathways may be a good strategy to prevent the progression of pathological hypertrophy...
  17. pmc M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues
    Verena Puxbaum
    Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, Muthgasse 18, A 1190 Vienna, Austria
    J Hepatol 57:337-43. 2012
    ..Thus, M6P/IGF2R is considered a putative liver tumor suppressor. The aim of this study was to establish the impact of the receptor on the invasive properties of liver cells...
  18. ncbi The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells
    A Oshima
    E A Doisy Department of Biochemistry, St Louis University School of Medicine, Missouri 63104
    J Biol Chem 263:2553-62. 1988
    ....
  19. ncbi Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor
    B Schmidt
    Georg August Universitat, Zentrum für Biochemie und Molekulare Zellbiologie, Abteilung Biochemie II, Gottingen, Federal Republic of Germany
    J Biol Chem 270:14975-82. 1995
    ..Residues 1508-1566, which are shared by the 23-kDa IGF-II-binding fragment and repeat 11, are proposed to form the IGF-II binding site of the M6P/IGF-II receptor...
  20. pmc Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein
    J G Orsel
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 97:9047-51. 2000
    ..Although crystallography will be needed to define the precise interaction interface, these data provide an initial structural basis for TIP47-CI-MPR association...
  21. pmc Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur
    James Brown
    Cancer Research UK Receptor Structure Research Group, Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    EMBO J 21:1054-62. 2002
    ..The structure factors and coordinates of IGF2R domain 11 have been deposited in the Protein Data Bank (accession codes 1GP0 and 1GP3)...
  22. pmc Decreased expression of the mannose 6-phosphate/insulin-like growth factor-II receptor promotes growth of human breast cancer cells
    Zhihong Chen
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    BMC Cancer 2:18. 2002
    ..However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies...
  23. ncbi Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo
    David B O'Gorman
    Kolling Institute of Medical Research, University of Sydney and Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Endocrinology 143:4287-94. 2002
    ..Overall, the findings in this study are consistent with the hypothesis that the IGF-II/M6PR suppresses tumor growth...
  24. ncbi Opposing roles for the insulin-like growth factor (IGF)-II and mannose 6-phosphate (Man-6-P) binding activities of the IGF-II/Man-6-P receptor in the growth of prostate cancer cells
    Beverly S Schaffer
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Endocrinology 144:955-66. 2003
    ..The magnitude of each activity in a given cell type seems to determine whether the net effect of the IGF2R on cell growth is inhibitory or stimulatory...
  25. ncbi Structural insights into the interaction of insulin-like growth factor 2 with IGF2R domain 11
    Christopher Williams
    Department of Organic and Biological Chemistry, School of Chemistry, Cantock s Close, University of Bristol, Bristol, United Kingdom
    Structure 15:1065-78. 2007
    ..The models reveal that the molecular interaction is driven by critical hydrophobic residues on IGF2 and IGF2R, while a ring of flexible, charged residues on IGF2R may modulate binding...
  26. pmc Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor
    Herbert B Schiller
    Department of Molecular Immunology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, A 1090 Vienna, Austria
    Mol Biol Cell 20:745-56. 2009
    ..We conclude that M6P/IGF2R controls cell invasion by regulating alphaV integrin expression and by accelerating uPAR cleavage, leading to the loss of the urokinase/vitronectin/integrin-binding site on uPAR...
  27. doi The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells
    Olivia C Probst
    Institute of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Int J Cancer 124:2559-67. 2009
    ..These results indicate that the M6P/IGF2R status influences the metastatic propensity of squamous cell carcinomas...
  28. ncbi Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations
    J K Killian
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hum Mutat 18:25-31. 2001
    ..Three identified amino-acid variants in the M6P/IGF2R ligand-binding domains may be under selection in humans...
  29. ncbi Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Growth Horm IGF Res 15:363-8. 2005
    ..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
  30. ncbi The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells
    Hesham M El-Shewy
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 282:26150-7. 2007
    ..These data indicate that endogenous IGF-1 and IGF-2 receptors can independently initiate ERK1/2 signaling and point to a potential physiologic role for IGF-2 receptors in the cellular response to IGF-2...
  31. ncbi Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 211:11-25. 1998
    ..We present an epigenetic model of information processing related to cell proliferation. The model is a dynamical network that uses continuous logic to learn its rules from changing conditions...
  32. doi Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes
    Nilani Jeyaratnaganthan
    The Medical Research Laboratories, Clinical Institute of Medicine and Medical Department M, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 20:185-91. 2010
    ..As IGF-II appears to be nutritionally regulated, we studied the impact of obesity, type 2 diabetes (T2D) and weight loss on circulating levels of IGF-II and its soluble receptor...
  33. ncbi Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids
    J X Kang
    Department of Medicine, Massachusetts General Hospital, Charlestown 02129 2000, USA
    Cell Growth Differ 10:591-600. 1999
    ....
  34. ncbi Mechanisms for high affinity mannose 6-phosphate ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor
    J C Byrd
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    J Biol Chem 275:18638-46. 2000
    ....
  35. ncbi Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor
    S Zaina
    Department of Zoology, University of Oxford, United Kingdom
    Endocrinology 139:3886-95. 1998
    ..These results support a significant role for the sIGF2R in local modulation of organ size in vivo...
  36. ncbi Control of insulin-like growth factor-II/mannose 6-phosphate receptor gene transcription by proximal promoter elements
    Z Liu
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Mol Endocrinol 9:1477-87. 1995
    ..Our observations thus represent a first step toward characterizing the developmental, epigenetic, and tissue-specific factors that control IGF-II/MPR gene expression...
  37. pmc Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes
    J X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 95:13687-91. 1998
    ..Therefore, our observations may have important implications for the understanding of the diverse biological effects of retinoids...
  38. ncbi Domain interactions of the mannose 6-phosphate/insulin-like growth factor II receptor
    Jodi L Kreiling
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    J Biol Chem 280:21067-77. 2005
    ..We conclude that there is no finite M6P/IGF2R dimerization domain, but rather that interactions between dimer partners occur all along the extracytoplasmic region of the receptor...
  39. ncbi Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor
    J M Dong
    Department of Physiology, School of Medicine and Veterinary Medicine, Tufts University, Boston, Massachusetts 02111
    J Biol Chem 265:4210-7. 1990
    ....
  40. ncbi The majority of clathrin coated vesicles from lactating rabbit mammary gland arises from the secretory pathway
    A Pauloin
    INRA, Laboratoire de Biologie Cellulaire et Moleculaire, France
    J Cell Sci 112:4089-100. 1999
    ....
  41. ncbi Characterization of early and late endocytic compartments of the transferrin cycle. Transferrin receptor antibody blocks erythroid differentiation by trapping the receptor in the early endosome
    I Killisch
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    J Cell Sci 103:211-32. 1992
    ..However, this condition did not affect the transport kinetics of horseradish peroxidase from the medium to the PLC...
  42. ncbi Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking
    O Varlamov
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 114:311-22. 2001
    ..These results are consistent with the model that PP2A is involved in the trafficking of proteins between a TGN recycling loop and a cell-surface recycling loop, but is not involved in the individual recycling loops...
  43. ncbi Sorting of major cargo glycoproteins into clathrin-coated vesicles
    Kouki Harasaki
    University of Cambridge, Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    Traffic 6:1014-26. 2005
    ..contained three prominent high molecular-weight proteins: the cation-independent mannose 6-phosphate receptor (CIMPR), carboxypeptidase D (CPD) and low-density lipoprotein receptor-related protein 1 (LRP1)...
  44. ncbi Renin/prorenin receptors
    G Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, College de France, Unit of Experimental Medicine, Paris, France
    Kidney Int 69:1503-6. 2006
    ....
  45. doi VZV infection of keratinocytes: production of cell-free infectious virions in vivo
    Michael D Gershon
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Curr Top Microbiol Immunol 342:173-88. 2010
    ..Evidence in support of these hypotheses includes observations of the VZV-infected human epidermis and studies of guinea pig neurons in an in vitro model system...
  46. ncbi Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor
    Sreelatha T Reddy
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 279:38658-67. 2004
    ..Taken together, these results demonstrate that the CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9...
  47. ncbi Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues
    Oliver J Zaccheo
    Cancer Research UK Molecular Oncology and Growth Factor Research Group, Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Mol Biol 359:403-21. 2006
    ..These findings have implications for the molecular architecture and evolution of the domain 11 IGF-II-binding site, and the potential interactions with other domains of IGF2R...
  48. ncbi Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation
    Robert J Wood
    Cancer and Molecular Immunology Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Acton, Australian Capital Territory 2601, Australia
    J Biol Chem 283:4165-76. 2008
    ..In this study, we identify the 300-kDa cation-independent mannose 6-phosphate receptor (CIMPR) as a cell surface receptor for heparanase...
  49. ncbi The kangaroo cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II with low affinity
    C A Yandell
    Cooperative Research Centre for Tissue Growth and Repair, P O Box 10065, Adelaide B C, South Australia, Australia, 5000
    J Biol Chem 274:27076-82. 1999
    ..Thus, the acquisition of a high-affinity binding site for regulating IGF-II appears to be a recent event specific to the eutherian lineage...
  50. pmc Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes
    Zhihong Chen
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    BMC Cell Biol 5:15. 2004
    ..However, involvement of M6P/IGF2R in the pathogenesis of these conditions has not been determined. Thus, the objective of this study was to determine the role of M6P/IGF2R in regulation of cardiac myocyte growth and apoptosis...
  51. ncbi Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air
    Yoko Yamasaki
    Department of Human Genetics, Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Mol Genet 14:2511-20. 2005
    ....
  52. ncbi Sertoli cell-spermatogenic cell interaction: the insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor mediates changes in spermatogenic cell gene expression in mice
    J K Tsuruta
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7500, USA
    Biol Reprod 53:1454-64. 1995
    ..Our results provide direct evidence that IGF-II/Cl-MPR ligands secreted by Sertoli cells can modulate gene expression in spermatogenic cells and strongly suggest that they are important in the regulation of spermatogenesis...
  53. ncbi Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic
    Lori L Tortorella
    Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Traffic 8:402-13. 2007
    ..These results demonstrate that the acidic cluster/dileucine motif of CI-MPR is critical for receptor sorting at early stages of intracellular transport following endocytosis...
  54. ncbi Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome
    C A Chayko
    Center for Reproductive Biology Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2633, USA
    J Androl 21:944-53. 2000
    ..These results suggest that the targeted disruption of either MPR does not result in decreased acrosomal targeting efficiency...
  55. pmc Carbohydrate-remodelled acid alpha-glucosidase with higher affinity for the cation-independent mannose 6-phosphate receptor demonstrates improved delivery to muscles of Pompe mice
    Yunxiang Zhu
    Genzyme Corporation, 31 New York Avenue, Framingham, MA 01701 9322, USA
    Biochem J 389:619-28. 2005
    ..These results demonstrate that remodelling the carbohydrate of rhGAA to improve its affinity for the CI-MPR represents a feasible approach to enhance the efficacy of enzyme replacement therapy for Pompe disease...
  56. ncbi The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network
    Miriam V Bujny
    The Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK
    J Cell Sci 120:2010-21. 2007
    ....
  57. pmc Strategies for carbohydrate recognition by the mannose 6-phosphate receptors
    Nancy M Dahms
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Glycobiology 18:664-78. 2008
    ..Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues...
  58. pmc Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor
    Linda J Olson
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 107:12493-8. 2010
    ..These results show the mechanism by which the CI-MPR recognizes Man-P-GlcNAc-containing ligands and provides new avenues to investigate the role of phosphodiester-containing lysosomal enzymes in the biogenesis of lysosomes...
  59. ncbi The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms
    S Zaina
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
    J Biol Chem 273:28610-6. 1998
    ....
  60. pmc The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin
    Stephane Lefrancois
    Department of Anatomy and Cell Biology, McGill University, 3640 University Montreal, Quebec, Canada H3A 2B2
    EMBO J 22:6430-7. 2003
    ..In conclusion, our results show that the trafficking of SAPs is dependent on sortilin, demonstrating a novel lysosomal trafficking...
  61. pmc Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport
    Jez G Carlton
    Henry Wellcome Integrated Signalling Laboratories, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK
    J Cell Sci 118:4527-39. 2005
    ....
  62. pmc Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes
    S C Ley
    National Institute for Medical Research, London, United Kingdom
    J Cell Biol 125:639-49. 1994
    ..Furthermore, the distribution of fyn in mitotic cells raises the possibility that it functions at the M phase of the cell cycle...
  63. pmc Cloning and expression of the cDNA of chicken cation-independent mannose-6-phosphate receptor
    M Zhou
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, MO 63104, USA
    Proc Natl Acad Sci U S A 92:9762-6. 1995
    ..Expression of the functional chicken CI-MPR in mice lacking the mammalian CI-MPR should clarify the controversy over the physiological role of the IGF-II-binding site in mammalian CI-MPR homologs...
  64. pmc The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide
    Ester Damen
    Department of Cell Biology, Faculty of Sciences, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Biochem J 398:399-409. 2006
    ..The potential significance of these findings with respect to regulation of transport of cycling trans-Golgi network proteins is discussed...
  65. pmc Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain
    Cheryl Hawkes
    Centre for Alzheimer and Neurodegenerative Research, Departments of Medicine Neurology and Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Am J Pathol 169:1140-54. 2006
    ....
  66. doi Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes
    J Brown
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Vitam Horm 80:699-719. 2009
    ..Characterization of ligand:IGF2R interactions is vital for the understanding of the mechanism of IGF2R actions and will allow the development of specific cancer therapies in the future...
  67. pmc Cation-independent mannose 6-phosphate receptor: a composite of distinct phosphomannosyl binding sites
    Richard N Bohnsack
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 284:35215-26. 2009
    ..Together, these data indicate that the assembly of three unique carbohydrate binding sites allows the CI-MPR to interact with the structurally diverse phosphorylated N-glycans it encounters on newly synthesized lysosomal enzymes...
  68. ncbi Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    M M Lau
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:2953-63. 1994
    ..These results show that Igf2r is paternally imprinted and reveal that the receptor is crucial for regulating normal fetal growth, circulating levels of IGF2, and heart development...
  69. ncbi Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo
    W Lerchner
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 61:141-9. 1997
    ..5 of development. Thus, for Igf2r, the onset of monoallelic expression occurs in all cells during the implantation period and paternal repression is maintained in all tissues of the late developing embryo...
  70. pmc Structure of uPAR, plasminogen, and sugar-binding sites of the 300 kDa mannose 6-phosphate receptor
    Linda J Olson
    Department of Biochemistry, Medical College of Wisconsin, Watertown Plank Road, Milwaukee, WI 53226, USA
    EMBO J 23:2019-28. 2004
    ....
  71. ncbi EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval
    Suzanne Gokool
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Traffic 8:1873-86. 2007
    Endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR) requires the function of the retromer complex...
  72. ncbi Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II
    Chun Hsien Chu
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 402, Taiwan, Republic of China
    Chin J Physiol 52:31-7. 2009
    ..Improving IGF1R activity and suppressing IGF2R may be a good strategy to prevent the progression of heart disease with cardiomyocyte apoptosis...
  73. ncbi Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene
    Z Q Wang
    Research Institute for Molecular Pathology I M P, Vienna, Austria
    Nature 372:464-7. 1994
    ..A few (-/+) mice reactivated their paternal Igf2/Mpr allele in some tissues and survived to adults. But no (-/-) mice survived, indicating a role for the reactivated paternal allele in postnatal survival...
  74. ncbi The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor
    Linda J Olson
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 279:34000-9. 2004
    ..The structure reveals the unique architecture of this carbohydrate binding pocket and provides insight into the ability of this site to recognize a variety of mannose-containing sugars...
  75. ncbi Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Cambridge, CB2 0XY, UK
    J Cell Sci 120:2378-89. 2007
    The cation-independent mannose 6-phosphate receptor (CIMPR) cycles between the trans-Golgi network (TGN) and endosomes to mediate sorting of lysosomal hydrolases. The endosome-to-TGN retrieval of the CIMPR requires the retromer complex...
  76. doi Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting
    Audrey Jeanjean
    Institut des Biomolecules Max Mousseron, UMR 5247, CNRS, Université Montpellier 2 et 1, Bâtiment de Recherche Max Mousseron, Ecole Nationale Superieure de Chimie de Montpellier, 8 rue de l Ecole Normale, F 34296 Montpellier Cedex 05, France
    Bioorg Med Chem Lett 18:6240-3. 2008
    ..Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting...
  77. doi In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor
    Lisa M Schimanski
    Weatherall Institute, Oxford University, UK
    Blood Cells Mol Dis 43:180-93. 2009
    ..However, it remains to be determined whether endogenous HFE in vivo also acquires the mannose-6 phosphate modification and binds to CI-MPR...
  78. pmc Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5
    Matthew N J Seaman
    University of Cambridge, Cambridge Institute for Medical Research, Department of Clinical Biochemistry, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK
    J Cell Sci 122:2371-82. 2009
    ..We therefore propose that recruitment of the cargo-selective VPS35/29/26 complex is catalysed by Rab7 and inhibited by the Rab-GAP protein, TBC1D5...
  79. ncbi Parental imprinting of the Mas protooncogene in mouse
    A J Villar
    Laboratory of Radiobiology and Environmental Health, University of California, San Francisco 94143
    Nat Genet 8:373-9. 1994
    ..Our results demonstrate parental imprinting of Mas and suggest that the maternally inherited allele is transcriptionally repressed in a developmental and tissue-specific manner...
  80. pmc Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis
    R A Heinzen
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840 2999, USA
    Infect Immun 64:796-809. 1996
    ..These observations are in sharp contrast to those for C. burnetii, which by all criteria resides in a typical phagolysosome...
  81. ncbi The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters
    N Schweifer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mamm Genome 7:735-40. 1996
    ..The Lx1 gene maps very close to the imprinted Igf2r/Mpr300 gene on mouse Chromosome (Chr) 17, in a region that is syntenic to human Chr 6q...
  82. ncbi An arrested late endosome-lysosome intermediate aggregate observed in a Chinese hamster ovary cell mutant isolated by novel three-step screening
    M Ohashi
    Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    J Cell Sci 112:1125-38. 1999
    ..LEX1 mutant cells would be helpful for the dissection of the as yet unrevealed details of the late endocytic membrane dynamics and for the identification of factors involved in the process arrested by the mutation...
  83. pmc Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain
    Teresa Rinaldi
    Pasteur Institute Cenci Bolognetti Foundation and the Department of Cell and Developmental Biology, University of Rome I, 00185 Rome, Italy
    Biochem J 381:275-85. 2004
    Substrates destined for degradation by the 26 S proteasome are labelled with polyubiquitin chains. Rpn11/Mpr1, situated in the lid subcomplex, partakes in the processing of these chains or in their removal from substrates bound to the ..
  84. pmc Interactions between imprinting effects in the mouse
    Bruce M Cattanach
    Mammalian Genetics Unit, Medical Research Council, Oxfordshire OX11 0RD, United Kingdom
    Genetics 168:397-413. 2004
    ..The classical Igf2-Igf2r axis may therefore be unique. The findings involve reinterpretation of older imprinting data and consequently revision of the mouse imprinting map...
  85. pmc Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network
    Rawshan Choudhury
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Mol Biol Cell 16:3467-79. 2005
    ..These findings suggest a role for OCRL1 in clathrin-mediated trafficking of proteins from endosomes to the TGN and that defects in this pathway might contribute to the Lowe syndrome phenotype...
  86. pmc The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export
    Christine I M Seidl
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, c o Institute of Genetics, Max F Perutz Laboratories, Vienna Biocenter, Dr Bohr Gasse 9 4, A 1030 Vienna, Austria
    EMBO J 25:3565-75. 2006
    ..These features show that Air is an atypical RNAPII transcript whose properties indicate that its mode of action in gene silencing may not depend on the RNA per se but instead is related to its actual transcription...
  87. ncbi Radiation-induced posttranscriptional control of M6P/IGF2r expression in breast cancer cell lines
    Keisuke S Iwamoto
    Roy E Coats Research Laboratories, Department of Radiation Oncology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Mol Carcinog 46:497-502. 2007
    ..This is a novel find that underscores the importance of posttranscriptional control of radiation-induced gene expression-a phenomenon that has often been paradigmatically attributed to transcriptional control...
  88. ncbi Imprinting of opossum Igf2r in the absence of differential methylation and air
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Epigenetics 1:49-54. 2006
    ..Thus, the regulatory mechanisms of Igf2r imprinting did not evolve convergently within the Therian subclass of mammals...
  89. ncbi Distribution of L-azetidine-2-carboxylate N-acetyltransferase in yeast
    Masaru Wada
    Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
    Biosci Biotechnol Biochem 72:582-6. 2008
    The budding yeast Saccharomyces cerevisiae Sigma1278b contains the MPR1 gene encoding N-acetyltransferase, which detoxifies the L-proline analog L-azetidine-2-carboxylate (AZC)...
  90. pmc HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice
    Katelyn M Atkins
    Vollum Institute, Portland, Oregon 97239, USA
    J Biol Chem 283:11772-84. 2008
    ..Together, these results demonstrate PACS-2 is required for Nef action and sorting of itinerant membrane cargo in the TGN/endosomal system...
  91. doi The (pro)renin receptors
    Genevieve Nguyen
    INSERM Unit 833, College de France, 11 place Marcelin Berthelot, Paris, France
    J Mol Med (Berl) 86:643-6. 2008
    ..Experimental models suggest that increased (P)RR synthesis and/or activation may be relevant to diseases, especially to high blood pressure, to cardiac fibrosis associated with hypertension, and to diabetic nephropathy...
  92. doi Igf2r improves the survival and transmission ratio of Igf2 transgenic mice
    Dimitrina D Pravtcheva
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Reprod Dev 75:1678-87. 2008
    ....
  93. ncbi Derivation of embryonic germ cells from post migratory primordial germ cells, and methylation analysis of their imprinted genes by bisulfite genomic sequencing
    Sang Woo Shim
    Department of Bioscience and Biotechnology, Bio Organ Research Center, Konkuk University, Seoul 143 701, Korea
    Mol Cells 25:358-67. 2008
    ..These results suggest that in vitro derived EGCs acquire different epigenotypes from their parental in vivo migratory PGCs, and that sex-specific de novo methylation occurs in the Igf2 and H19 genes of EGCs...
  94. pmc Genetic variation in insulin-like growth factors and brain tumor risk
    Stefan Lonn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7238, USA
    Neuro Oncol 10:553-9. 2008
    ..Overall, our results do not provide strong evidence of associations of brain tumor risk with IGF polymorphic variants but identify several associations for glioma that warrant further examination in other, larger studies...
  95. doi Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling
    Ray Jade Chen
    Trauma and Emergency Center School of Medicine, China Medical University Hospital, Taichung 404, Taiwan, ROC
    J Mol Endocrinol 43:221-30. 2009
    ..Our findings demonstrate that IGF2R activation appears to induce cell apoptosis via Galphaq-deriving signaling cascades and its effect is completely different from IGF1R survival signaling...
  96. pmc Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 177:2446-58. 2010
    ..Mice with the Csf1r- driven Igf2r knockout should be useful for the investigation of macrophage-specific IGF2R function...
  97. doi Association between Gly1619ARG polymorphism of IGF2R domain 11 (rs629849) and advanced stage of oral cancer
    Angela J Yoon
    Division of Oral and Maxillofacial Pathology, Columbia University College of Dental Medicine, New York, NY, USA
    Med Oncol 29:682-5. 2012
    ..32). IGF2R genetic polymorphism may be associated with decreased function of IGF2 receptor there by contributing to the advancement and distant metastasis of localized oral cancer...
  98. pmc Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis
    Kazuhiko Matsuoka
    Department of Medicinal Biotechnology, Institute for Medicinal Research, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan
    Mol Ther 19:1017-24. 2011
    ....
  99. doi Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing
    Paulina A Latos
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria
    Science 338:1469-72. 2012
    ..Such a repressor function for lncRNA transcriptional overlap reveals a gene silencing mechanism that may be widespread in the mammalian genome, given the abundance of lncRNA transcripts...
  100. doi Influence of birth weight and gender on lipid status and adipose tissue gene expression in lambs
    Jacqueline M Wallace
    Rowett Institute of Nutrition and HealthUniversity of Aberdeen, Bucksburn, Aberdeen AB21 9SB, UK
    J Mol Endocrinol 53:131-44. 2014
    ....
  101. pmc Development to term of cloned cattle derived from donor cells treated with valproic acid
    Juliano Rodrigues Sangalli
    Departamento de Medicina Veterinaria, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de Sao Paulo, Pirassununga, Sao Paulo, Brazil Departamento de Cirurgia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil Department of Biomedical Science, Ontario Veterinary College, University of Guelph, Ontario, Canada
    PLoS ONE 9:e101022. 2014
    ..Altogether, these results show that in spite of the alterations in fibroblasts resulting from the treatment with VPA, their use as donor cells in SCNT did not improve pre- and post-implantation development of cloned cattle. ..

Research Grants38

  1. Nancy M Dahms; Fiscal Year: 2016
    ..These studies will also provide the structural basis for the design of improved therapeutics for the treatment of lysosomal storage disorders, and novel inhibitors of viral infection and growth factor activation. ..
  2. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2004
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  3. Roles of Retromer Complex in Development
    Xinhua Lin; Fiscal Year: 2013
    ..Defects in Wnt and Toll signaling pathways as well as epithelium polarity are associated with many human diseases including cancers. The outcomes of this application will help understanding related human disease processes. ..
  4. Dwight D Koeberl; Fiscal Year: 2014
    ..The study will be conducted at Duke University Hospital System with the review of the Duke Institutional Review Board under an investigator initiated IND. ..
  5. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
    ..abstract_text> ..
  6. Igf2r Tumor Suppression in Igf2 and TGFa Transgenic Mice
    DIMITRINA PRAVTCHEVA; Fiscal Year: 2004
    ..The combined results from these experiments will help evaluate the effectiveness of IGF2R as a tumor suppressor and its potential usefulness for gene therapy of human tumors. ..
  7. Insulin-like growth factor 2 receptor in CNS viral infection and inflammation
    Hyeon Sook Suh; Fiscal Year: 2012
    ....
  8. ANGELA GELLI; Fiscal Year: 2014
    ..The central hypothesis is that a newly identified secreted metalloprotease (Mpr1) stimulates the transmigration of cryptococci into the CNS by unmasking/stimulating surface receptors/ligands and/..
  9. Dissecting the innate immune response mediated by Arabidopsis Nudix hydrolase
    Yiji Xia; Fiscal Year: 2010
    ..An Arabidopsis Nudix hydrolase (MPR1) which hydrolyzes nucleotide derivatives has recently been identified as a key mediator of the basal innate immune ..
  10. TRANSPORT OF PESTICIDES MEDIATED BY MRP1 AND MRP3
    Lisa Bain; Fiscal Year: 2000
    ..We will examine the actual transport of pesticides by MPR1 and MPR3, determine whether this elimination alters toxicity to cells that overexpress these proteins, and ..
  11. Patterns /Expression Levels of Imprinted Genes in Clones
    Xiangzhong Yang; Fiscal Year: 2002
    ..abstract_text> ..
  12. Fluorescence-activated cell sorter-FACSAria
    David Mosser; Fiscal Year: 2007
    ..The application is being submitted on behalf of the newly formed Maryland Pathogen Research Institute (MPRI), which is physically located within the College of Life Sciences, but as a multidisciplinary research institute on ..
  13. CONSTRUCTION OF PROTON THERAPY CENTER
    John Cameron; Fiscal Year: 2002
    ..ft. of physics research space into a regional proton therapy center, the Midwest Proton Radiation Institute (MPRI). Clinical trials and research for development and optimization of new treatments will be conducted at MPRI...
  14. Mechanisms and significance of cublin-mediated HDL uptake
    WILLIAM ARGRAVES; Fiscal Year: 2009
    ..megalin, amnionless (AMN) and the cation-independent mannose 6-phosphate/insulin-like growth factor ll-receptor (CIMPR), to the process of embryonic uptake of maternal HDL...
  15. Genetic Susceptibility to Oral Premalignancies
    Athanasios Zavras; Fiscal Year: 2007
    ..The nesting of the project within the HPFS allows for longitudinal evaluations of validated data, increased recruitment and sample size, high quality DNA availability and overall increased feasibility. ..
  16. RETINOIDS, M6P/IGF II RECEPTOR & CELL GROWTH REGULATION
    Jing Kang; Fiscal Year: 2002
    ..This knowledge may lead to novel or more effective therapeutic and preventive approaches for cancer and developmental defects. ..
  17. Gene delivery to striated muscle by systemic AAV vectors
    Dwight D Koeberl; Fiscal Year: 2010
    ..Efficacious muscle-targeted gene therapy in GSD-II will have implications for gene therapy in other muscular dystrophies and myopathies. ..
  18. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
    ..These comparisons will guide preclinical experiments to further immunomodulatory gene therapy in Pompe disease and other lysosomal storage disorders. ..
  19. Omega-6/Omega-3 Fatty Acid Ratio and Tumorigenesis
    Jing Kang; Fiscal Year: 2009
    ..Information derived from these studies will increase our understanding of the importance of n-3 fatty acids as well as n-6/n-3 fatty acid ratio in cancer prevention and help guide dietary advice. ..
  20. Molecular Dissection of IGF2R Growth Suppressor Activity
    Richard MacDonald; Fiscal Year: 2004
    ..These studies will contribute to understanding the receptor's tumor suppressor function and permit rational design of strategies that exploit the IGF2R in cancer prevention and therapy. ..
  21. Genomics and Epigenomics of Fetal Growth Regulation
    Ronald M Adkins; Fiscal Year: 2010
    ..Statistical analyses will be performed to test the three hypotheses. Note: The only change from the original abstract is a change from 1,000 to 800 mothernewborn pairs. ..
  22. REGULATION OF NEUROPEPTIDE PROCESSING ENZYMES
    Lloyd Fricker; Fiscal Year: 2002
    ..The results of these studies will provide a better understanding of the enzymes involved with peptide biosynthesis. ..
  23. CELLULAR AND MOLECULAR BASIS OF HIV BASED THROMBOCYTOPEN
    Mariusz Ratajczak; Fiscal Year: 2002
    ..In toto, the studies proposed in this grant will increase the knowledge about pathogenesis of AIDS associated thrombocytopenia and may lead to development of new strategies for its treatment of prevention. (End of Abstract) ..
  24. Peptidomics of Cocaine and Amphetamine Abuse
    Lloyd Fricker; Fiscal Year: 2005
    ..Taken together, these studies will provide a better understanding of the regulation of neuropeptides, both known and novel, in drug abuse. ..
  25. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..This work will be of relevance for designing strategies to block the SDF-1-CXCR4 axis to treat CXCR4-positive cancers. ..
  26. SAGE Analysis of Murine Oocyte Maturation
    CHARLOTTE FARIN; Fiscal Year: 2004
    ..Differential expression of the candidate gene sequences will be verified using reverse transcription-polymerase chain reaction (RT-PCR). ..
  27. Function of Carboxypeptidase D
    Lloyd Fricker; Fiscal Year: 2008
    ..The overall goal of this proposal is to understand the role of each domain within CPD, using a simple organism for which CPD mutants exist and which is amenable to transgenic analysis. ..
  28. Iron and Atherosclerosis
    Subha Raman; Fiscal Year: 2006
    ..Subgroup analyses will include comparison of the presence of iron symptomatic versus asymptomatic patients and women versus age-matched men. ..
  29. SIMPLE VERTEBRATE AND INVERTEBRATE SYSTEMS
    Michael Gershon; Fiscal Year: 2005
    ..Almost all trainees have continued to be productive in biomedical science and some have acquired leadership positions. ..
  30. Imprinted PEG3 domain at 19q13.4 and carcinogenesis
    Susan Murphy; Fiscal Year: 2002
    ..These studies will help clarify the role of the human PEG3 isoforms in the control of cellular growth, and may further contribute potential diagnostic and therapeutic targets for ovarian cancer. ..
  31. Development of the enteric nervous system: Cells & genes
    Michael Gershon; Fiscal Year: 2006
    ..The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend. [unreadable] [unreadable]..
  32. Pathogenesis of autoimmune myositis: Role of MHC Class 1
    Kanneboyina Nagaraju; Fiscal Year: 2009
    ..abstract_text> ..
  33. MECHANISMS OF GENOMIC IMPRINTING
    Andrew Hoffman; Fiscal Year: 2007
    ..Ultimately, it will be possible to develop a comprehensive chromatin/DNA model of imprinting. [unreadable] [unreadable]..
  34. Maternal-Fetal Conflict: The Effect of Imprinted Genes on Fetal Growth
    Ronald M Adkins; Fiscal Year: 2010
    ..Dietary survey instruments during pregnancy and just afterwards will be used to determine the maternal intake of nutrients vital to DNA methylation. Statistical analyses will be performed to test the three hypotheses. ..
  35. Quantitative Peptidomics of Food Deprivation
    Lloyd Fricker; Fiscal Year: 2005
    ..The studies in this initial R21 will provide an unbiased survey of neuropeptides that are altered by food deprivation, and which may therefore be involved in regulating food intake and/or body weight. ..
  36. CELL BIOLOGY OF CARBOXYPEPTIDASE D
    Lloyd Fricker; Fiscal Year: 2003
    ..This will provide a better understanding of the proteins, either known or novel, that interact with CPD. These studies on CPD will advance our knowledge of protein trafficking in neuroendocrine cells. ..