CHRNA4

Summary

Gene Symbol: CHRNA4
Description: cholinergic receptor nicotinic alpha 4 subunit
Alias: BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4, neuronal acetylcholine receptor subunit alpha-4, cholinergic receptor, nicotinic alpha 4, cholinergic receptor, nicotinic, alpha 4 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 4, neuronal nicotinic acetylcholine receptor alpha-4 subunit
Species: human

Top Publications

  1. ncbi Promoter analysis of the neuronal nicotinic acetylcholine receptor alpha4 gene: methylation and expression of the transgene
    H Watanabe
    Neurobiologie moleculaire, CNRS URA 1284, Institut Pasteur, Paris, France
    Eur J Neurosci 10:2244-53. 1998
  2. doi The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat
    M S Thomsen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, Ballerup, Denmark
    Neuroscience 154:741-53. 2008
  3. doi Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia
    Najla Taslim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Behav Brain Res 217:282-92. 2011
  4. pmc A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression
    Joshua S Talboom
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Horm Behav 58:917-28. 2010
  5. doi Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells
    Hui Zhen Nie
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
    Brain Res 1356:112-20. 2010
  6. ncbi The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor
    Lin Lin
    Neuroscience Center of Excellence, Louisiana, New Orleans 70112, USA
    J Biol Chem 277:41872-8. 2002
  7. ncbi Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors
    Mary Beth Ficklin
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:34088-95. 2005
  8. pmc A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Hum Genet 75:112-21. 2004
  9. ncbi Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence
    Ming D Li
    Hum Mol Genet 14:1211-9. 2005
  10. ncbi Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients
    Soon Ae Kim
    Department of Pharmacology, Eulji University School of Medicine, 143 5 Yongdu Dong, Jung Gu, Daejeon, 301 832, Korea
    Alcohol 34:115-20. 2004

Research Grants

  1. Nicotine Addiction: ACh Receptors and Secretion
    Aaron Fox; Fiscal Year: 2002
  2. Eliot R Spindel; Fiscal Year: 2015
  3. Interventions to Test the alpha 7 Nicotinic Receptor Model in Schizophrenia
    Stephen Deutsch; Fiscal Year: 2009
  4. Maurizio Fava; Fiscal Year: 2015
  5. Mechanisms of nicotine-mediated decrease in L-dopa induced-dyskinesias
    Maryka Quik; Fiscal Year: 2013
  6. The Neuronal alpha-bungarotoxin Binding Site
    WILLIAM NATHAN GREEN; Fiscal Year: 2012
  7. Role of calcium-dependent mechanisms in nicotine's tolerance and effects
    MOHAMAD IMAD DAMAJ; Fiscal Year: 2010
  8. SNRP Program at UCC
    Maria Bykhovskaia; Fiscal Year: 2012
  9. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
  10. Alessandro Guidotti; Fiscal Year: 2015

Detail Information

Publications299 found, 100 shown here

  1. ncbi Promoter analysis of the neuronal nicotinic acetylcholine receptor alpha4 gene: methylation and expression of the transgene
    H Watanabe
    Neurobiologie moleculaire, CNRS URA 1284, Institut Pasteur, Paris, France
    Eur J Neurosci 10:2244-53. 1998
    Neuronal nicotinic acetylcholine receptor (nAChR) subunit genes compose a family of genes. The major isoform of nAChR in the brain is made up of the alpha4 and beta2 subunits and possesses a high affinity for nicotine...
  2. doi The selective alpha7 nicotinic acetylcholine receptor agonist A-582941 activates immediate early genes in limbic regions of the forebrain: Differential effects in the juvenile and adult rat
    M S Thomsen
    Department of Translational Neurobiology, Neurosearch A S, Pederstrupvej 93, Ballerup, Denmark
    Neuroscience 154:741-53. 2008
    Due to the cognitive-enhancing properties of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists, they have attracted interest for the treatment of cognitive disturbances in schizophrenia...
  3. doi Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia
    Najla Taslim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Behav Brain Res 217:282-92. 2011
    We have demonstrated that nicotine attenuated ethanol-induced ataxia via nicotinic-acetylcholine-receptor (nAChR) subtypes α(4)β(2) and α(7). In the present study, ethanol (2g/kg; i.p...
  4. pmc A component of Premarin(®) enhances multiple cognitive functions and influences nicotinic receptor expression
    Joshua S Talboom
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Horm Behav 58:917-28. 2010
    ..the effects of ∆(8)E1 and equilin treatments on a cognitive battery and cholinergic nicotinic receptors (nAChR)...
  5. doi Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells
    Hui Zhen Nie
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China
    Brain Res 1356:112-20. 2010
    Multiple lines of evidence have implicated that nicotinic acetylcholine receptor (nAChR) may be an important therapeutic target for the treatment of Alzheimer's disease (AD)...
  6. ncbi The calcium sensor protein visinin-like protein-1 modulates the surface expression and agonist sensitivity of the alpha 4beta 2 nicotinic acetylcholine receptor
    Lin Lin
    Neuroscience Center of Excellence, Louisiana, New Orleans 70112, USA
    J Biol Chem 277:41872-8. 2002
    ..Collectively, these results suggest that VILIP-1 represents a novel modulator of alpha4beta2 AChRs that increases their surface expression levels and agonist sensitivity in response to changes in the intracellular levels of calcium...
  7. ncbi Ubiquilin-1 regulates nicotine-induced up-regulation of neuronal nicotinic acetylcholine receptors
    Mary Beth Ficklin
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:34088-95. 2005
    ..These data suggest that ubiquilin-1 limits the availability of unassembled nicotinic acetylcholine receptor subunits in neurons by drawing them to the proteosome, thus regulating nicotine-induced up-regulation...
  8. pmc A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Hum Genet 75:112-21. 2004
    ..We studied six single-nucleotide polymorphisms (SNPs) in the CHRNA4 gene and four SNPs in the CHRNB2 gene with respect to nicotine dependence in a collection of 901 subjects (815 ..
  9. ncbi Ethnic- and gender-specific association of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) with nicotine dependence
    Ming D Li
    Hum Mol Genet 14:1211-9. 2005
    We tested six single nucleotide polymorphisms (SNPs) in the alpha4 subunit gene (CHRNA4) and four SNPs in the beta2 subunit gene (CHRNB2) of nicotinic acetylcholine receptors (nAChRs) for association with nicotine dependence (ND), which ..
  10. ncbi Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients
    Soon Ae Kim
    Department of Pharmacology, Eulji University School of Medicine, 143 5 Yongdu Dong, Jung Gu, Daejeon, 301 832, Korea
    Alcohol 34:115-20. 2004
    ..and support the possibility that a polymorphism of the nicotinic acetylcholine receptor alpha4 subunit gene (CHRNA4) modulates enhancement of nicotinic receptor function by ethanol...
  11. pmc Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors
    Jie Wu
    Neurophysiology Laboratory, Division of Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013 4496, USA
    J Physiol 576:103-18. 2006
    Naturally expressed nicotinic acetylcholine receptors (nAChR) containing alpha4 subunits (alpha4*-nAChR) in combination with beta2 subunits (alpha4beta2-nAChR) are among the most abundant, high-affinity nicotine binding sites in the ..
  12. ncbi Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine
    Marissa A Ehringer
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado 80309, USA
    Am J Med Genet B Neuropsychiatr Genet 144:596-604. 2007
    ..We have examined two neuronal nicotinic receptor subunit genes (CHRNA4 and CHRNB2) for possible associations with nicotine and alcohol phenotypes, including measures of frequency of use ..
  13. ncbi Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks
    T Espeseth
    Center for the Study of Human Cognition, Department of Psychology, University of Oslo, and Department of Medical Biochemistry, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Neuroscience 147:974-85. 2007
    ..of early latency modality-specific event-related potential (ERP) components in vision and audition may indicate that the CHRNA4 polymorphism affects factors that are common to top-down modulation of sensory processing across modalities.
  14. ncbi Association of attentional network function with exon 5 variations of the CHRNA4 gene
    Georg Winterer
    Department of Psychiatry, Henirich Heine University, Duesseldorf, Germany
    Hum Mol Genet 16:2165-74. 2007
    ..by genetic variations within exon 5 of the alpha4 subunit of the nicotinergic acetylcholine receptor gene CHRNA4. The potential relevance of exon 5 is further emphasized by two recent family-based association studies of ..
  15. ncbi CHRNA4 and tobacco dependence: from gene regulation to treatment outcome
    Kent E Hutchison
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Arch Gen Psychiatry 64:1078-86. 2007
    Given the probable importance of the alpha4 subunit of the neuronal nicotinic acetylcholine receptor, the gene that codes for this subunit (CHRNA4) represents an excellent starting point for a genetic investigation of smoking behavior.
  16. pmc Both a nicotinic single nucleotide polymorphism (SNP) and a noradrenergic SNP modulate working memory performance when attention is manipulated
    Pamela M Greenwood
    George Mason University, Fairfax, VA 22030 4444, USA
    J Cogn Neurosci 21:2139-53. 2009
    ..Based on our previous report that the CHRNA4 rs#1044396 C/T nicotinic receptor SNP affected visuospatial attention, but not working memory, and the DBH rs#..
  17. doi Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans
    L P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenomics J 9:219-24. 2009
    Polymorphisms in the CHRNA4 gene coding the nicotinic acetylcholine receptor subunit alpha 4 have recently been suggested to play a role in the determination of smoking-related phenotypes...
  18. doi Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
    Jean Francois Etter
    Institute of Social and Preventive Medicine, Faculty of Medicine, University of Geneva, CMU, 1 rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Addict Behav 34:772-5. 2009
    ..Cotinine levels were higher in carriers of the CC genotype of CHRNA4 rs1044396 (371 ng/ml) than in those with the CT or TT genotypes (275 ng/ml, p=0.049), a difference of 0...
  19. pmc Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene
    Brian E Roe
    Department of Agricultural, Environmental and Development Economics, Ohio State University, Columbus, Ohio, USA
    PLoS ONE 4:e6704. 2009
    ..data identified two single nucleotide polymorphisms (SNPs) in the gene encoding the alpha 4 nicotine receptor (CHRNA4, rs4603829 and rs4522666) that are significantly associated with harm avoidance, a risk attitude measurement drawn ..
  20. doi Association of nAChR gene haplotypes with heavy alcohol use and body mass
    Sara Landgren
    Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
    Brain Res 1305:S72-9. 2009
    ..004) for the CCCC haplotype compared to non-carriers of these haplotypes. Moreover, one haplotype of the CHRNA4 (GGTG) was associated with increased body weight as compared to non-carriers of this haplotype, especially in the ..
  21. pmc Nicotinic receptor gene CHRNA4 interacts with processing load in attention
    Thomas Espeseth
    Department of Psychology, Center for the Study of Human Cognition, University of Oslo, Oslo, Norway
    PLoS ONE 5:e14407. 2010
    ..Pharmacological studies suggest that cholinergic neurotransmission mediates increases in attentional effort in response to high processing load during attention demanding tasks [1]...
  22. doi The nicotinic acetylcholine receptor gene CHRNA4 is associated with negative emotionality
    Sebastian Markett
    Department of Psychology, University of Bonn, Bonn, Germany sebastian markettuni bonn diff de
    Emotion 11:450-5. 2011
    Knock-out studies in mice suggest a role of the CHRNA4 gene in anxiety. In the present study we extend this finding to humans by means of a genetic association study...
  23. doi Association of CHRNA4 polymorphism with depression and loneliness in elderly males
    S J Tsai
    Department of Psychiatry, Taipei Veterans General Hospital School of Medicine, National Yang Ming University, Taipei, Taiwan
    Genes Brain Behav 11:230-4. 2012
    The cholinergic receptor, nicotinic, alpha 4 (CHRNA4) gene encodes the neuronal nicotinic acetylcholine receptor alpha-4 subunit...
  24. doi A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4
    P M Greenwood
    Arch Lab, Psychology Department, George Mason University, Fairfax, VA 22030 4444, USA
    Neurosci Biobehav Rev 36:1331-41. 2012
    ..electrophysiological, and imaging evidence, we advance an hypothesis for a cognitive phenotype of a SNP in the CHRNA4 gene encoding the α(4) subunit of α(4)β(2) nicotinic receptors...
  25. doi The dopamine D2 receptor gene DRD2 and the nicotinic acetylcholine receptor gene CHRNA4 interact on striatal gray matter volume: evidence from a genetic imaging study
    Sebastian Markett
    Department of Psychology, University of Bonn, Germany
    Neuroimage 64:167-72. 2013
    ..molecular genetic level: DRD2 rs6277, a single nucleotide polymorphism (SNP) on the dopamine D2 receptor gene and CHRNA4 rs1044396, a SNP on the nicotinic acetylcholine receptor gene interact on visuo-spatial and phonological working ..
  26. pmc Nominal association with CHRNA4 variants and nicotine dependence
    H M Kamens
    Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA
    Genes Brain Behav 12:297-304. 2013
    ..In this study, we examined the genetic association between variation in the genes that code for the α4 (CHRNA4) and β2 (CHRNB2) subunits of the nicotinic acetylcholine receptor and a quantitative measure of lifetime DSM-IV ..
  27. ncbi Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems
    R D Todd
    Department of Psychiatry, School of Medicine, Washington University, St Louis, MO 63110, USA
    Mol Psychiatry 8:103-8. 2003
    ..in the coding regions and intron/exon junctions of the nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4). Common polymorphisms were used for transmission disequilibrium test (TDT) analyses...
  28. pmc Association of alpha4beta2 nicotinic receptor and heavy smoking in schizophrenia
    Sophocles Voineskos
    Neurogenetics Section, Clarke Site, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ont
    J Psychiatry Neurosci 32:412-6. 2007
    ..Schizophrenia patients are usually heavy smokers. In this study we hypothesized that high-affinity nicotinic receptors are associated with smoking in such patients...
  29. doi Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia
    Paul Gierke
    Signal Transduction Research Group, Neuroscience Research Center, Charite, Universitaetsmedizin Berlin, Germany
    Neurobiol Dis 32:162-75. 2008
    ..expression of neuronal Ca(2+)-sensor VILIP-1 (visinin-like protein) and enhanced co-localization with alpha4beta2 nAChR in interneurons...
  30. pmc Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons
    C J Zhao
    Signal Transduction Research Group, Neuroscience Research Center, Charite, Universitaetsmedizin Berlin, Germany
    Mol Cell Neurosci 40:280-92. 2009
    ..to interact with the cytoplasmic loop of the alpha4-subunit of the alpha4beta2 nicotinic acetylcholine receptor (nAChR), which is the most abundant nAChR subtype with high-affinity for nicotine in the brain...
  31. doi The association between dopamine DRD2 polymorphisms and working memory capacity is modulated by a functional polymorphism on the nicotinic receptor gene CHRNA4
    Sebastian A Markett
    University of Bonn, Germany
    J Cogn Neurosci 22:1944-54. 2010
    ..The results are discussed with regard to their implication for working memory theories and their clinical relevance for treatment of substance abuse and schizophrenia...
  32. doi Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells
    Hussein A N Al-Wadei
    Experimental Oncology Laboratory, University of Tennessee, Knoxville, TN 37996, USA
    Lung Cancer 69:33-9. 2010
    ..This selective imbalance in stimulatory and inhibitory signaling may contribute to the development and progression of small airway-derived adenocarcinoma in women who smoke...
  33. pmc Association of CHRNA4 polymorphisms with smoking behavior in two populations
    Shizhong Han
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 156:421-9. 2011
    b>CHRNA4, the gene that encodes the nicotinic acetylcholine receptor α(4) subunit, is a potential candidate gene for nicotine dependence (ND)...
  34. ncbi A model for short alpha-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: comparison with long-chain alpha-neurotoxins and alpha-conotoxins
    D Yu Mordvintsev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry RAS, 117997, Miklukho Maklaya str, 16 10, GSP 7, Moscow, Russia
    Comput Biol Chem 29:398-411. 2005
    ..from snakes are highly selective antagonists of the muscle-type nicotinic acetylcholine receptors (nAChR)...
  35. ncbi Snake alpha-neurotoxin binding site on the Egyptian cobra (Naja haje) nicotinic acetylcholine receptor Is conserved
    Z Takacs
    Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Mol Biol Evol 18:1800-9. 2001
    ..represented by alpha-bungarotoxin (alpha-BTX) targeted against the nicotinic acetylcholine receptor (nAChR) of the neuromuscular junction. The model which presumes that cobras (Naja spp...
  36. pmc Pharmacology of nicotinic receptors in preBötzinger complex that mediate modulation of respiratory pattern
    Xuesi M Shao
    Department of Neurobiology, UCLA School of Medicine, Los Angeles, California 90095 1763, USA
    J Neurophysiol 88:1851-8. 2002
    ..The nicotinic acetylcholine receptor (nAChR) subtypes mediating these effects are unknown...
  37. doi Ultrastructural visualization of the transmembranous and cytomatrix-related part of nicotinic acetylcholine receptor of frog motor endplate by means of an immunochemical avidity of IgG for d-tubocurarine
    Keiji Hirai
    Department of Autonomic Physiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo
    Folia Histochem Cytobiol 46:111-6. 2008
    In the present study, a fine ultrastructural localization of nicotinic acetylcholine receptor (nAChR) was attempted, using d-tubocurarine (d-TC), a quaternary ammonium compound binding to nAChR...
  38. ncbi A nicotinic acetylcholine receptor is involved in the arosome reaction of human sperm initiated by recombinant human ZP3
    Christopher Bray
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616 8643, USA
    Biol Reprod 67:782-8. 2002
    ..Preincubation with three antagonists of the nicotinic acetylcholine receptor (nAChR), alpha-bungarotoxin (alpha-BTX, 100 nM), alpha-conotoxin IMI (alpha-CTX IMI, 250 nM and 25 nM), and ..
  39. doi Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties
    Marios Zouridakis
    Department of Biochemistry, Hellenic Pasteur Institute, 127, GR11521, Athens, Greece
    Biochim Biophys Acta 1794:355-66. 2009
    ..facilitate structural studies of the extracellular domain (ECD) of human alpha7 nicotinic acetylcholine receptor (nAChR), we designed several mutants, since the wild-type-ECD forms large oligomers and microaggregates, and expressed ..
  40. doi Nicotinic acetylcholine receptor gene expression is altered in burn patients
    Walid A Osta
    Department of Anesthesia, Wayne State University Detroit Medical Center, Detroit, MI 48201, USA
    Anesth Analg 110:1355-9. 2010
    ..Changes in nicotinic acetylcholine receptor (nAChR) subunit composition may alter electrophysiologic, pharmacologic, and metabolic characteristics of the receptor ..
  41. ncbi Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Dement Geriatr Cogn Disord 11:11-8. 2000
    ..One of the most prominent cholinergic deficits is the reduced number of nicotinic acetylcholine receptors (nAChR) in the brain...
  42. ncbi Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat
    R S Bitner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Building AP9A LL D 4N5, 100 Abbott Park Rd, Abbott Park, IL 60064 3500, USA
    Brain Res 938:45-54. 2002
    The alpha 7 nicotinic acetylcholine receptor (nAChR) subunit can be assembled to form a homomeric-pentamer with high permeability to calcium...
  43. ncbi Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists
    Deirdre S Stewart
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 45:10641-53. 2006
    A molecule as simple in structure as tetramethylammonium gates the nicotinic acetylcholine receptor (nAChR) with high efficacy...
  44. pmc Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor
    Ayman K Hamouda
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 47:12787-94. 2008
    The Torpedo nicotinic acetylcholine receptor (nAChR) is the only member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) that is available in high abundance in a native membrane preparation...
  45. pmc In silico models for the human alpha4beta2 nicotinic acetylcholine receptor
    Esmael J Haddadian
    Department of Anesthesiology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Phys Chem B 112:13981-90. 2008
    The neuronal alpha4beta2 nicotinic acetylcholine receptor (nAChR) is one of the most widely expressed nAChR subtypes in the brain...
  46. pmc Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation
    N Le Novère
    Centre National de la Recherche Scientifique URA D1284 Neurobiologie Moléculaire, Institut Pasteur, 75015 Paris, France
    Biophys J 76:2329-45. 1999
    Abstract A refined prediction of the nicotinic acetylcholine receptor (nAChR) subunits' secondary structure was computed with third-generation algorithms...
  47. ncbi Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways
    Imran Khan
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Comp Neurol 467:44-59. 2003
    Neuronal nicotinic receptors (nAChR) are pentameric assemblies of subunits of a gene family where specified combinations of alpha and beta subunits form functional receptors...
  48. ncbi Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist
    Roger L Papke
    University of Florida College of Medicine, Department of Pharmacology and Therapeutics, Gainesville, FL 32610 0267, USA
    Neurosci Lett 378:140-4. 2005
    The alpha7 nicotinic acetylcholine receptor (nAChR)-selective partial agonist tropisetron is a conjugate of an indole and a tropane group...
  49. ncbi Structural and functional changes induced in the nicotinic acetylcholine receptor by membrane phospholipids
    Asia M Fernández-Carvajal
    Instituto de Biologia Molecular y Celular, Universidad Miguel Hernandez, Elche, Spain
    J Mol Neurosci 30:121-4. 2006
    ..The nicotinic acetylcholine receptor (nAChR) from Torpedo is the most extensively studied member of the LGIC family and consists of a pentameric transmembrane ..
  50. ncbi 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase
    Kelly P Cosgrove
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Nucl Med 48:1633-40. 2007
    ..The nicotinic acetylcholine receptor (nAChR) system has been implicated in a variety of psychiatric disorders, including tobacco smoking, for which there is ..
  51. pmc Nicotinic receptors concentrated in the subsynaptic membrane do not contribute significantly to synaptic currents at an embryonic synapse in the chicken ciliary ganglion
    Peter B Sargent
    Department of Cell and Tissue Biology and the Neuroscience Graduate Program, University of California, San Francisco, San Francisco, California 94143 0640, USA
    J Neurosci 29:3749-59. 2009
    ..The contribution that each nAChR makes to uniquantal response shape was determined by blocking one nAChR type; pharmacologically isolated alpha7-..
  52. ncbi A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol
    Christopher M Butt
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309 0447, USA
    Alcohol Clin Exp Res 27:733-42. 2003
    Several studies indicate that ethanol enhances the activity of alpha4beta2 nicotinic acetylcholine receptors (nAChR)...
  53. ncbi The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenes
    Xiao lan Qi
    Department of Pathology and Molecular Biology, Guiyang Medical University, Guiyang 550004, Guizhou, PR China
    Neurochem Int 51:377-83. 2007
    In order to examine the neuroprotective effects of the alpha7 nicotinic receptor (nAChR) in relationship to the pathogenesis of Alzheimer's disease (AD), neuroblastoma (SH-SY5Y) cells were transfected with small interference RNAs (siRNAs)..
  54. ncbi A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
    Jianguo Ji
    Neuroscience Research, Department R47W, Bldg AP9A, Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL 60064, USA
    Biochem Pharmacol 74:1253-62. 2007
    ..2.0]heptan-6-yl]nicotinonitrile (A-366833) is a novel nicotinic acetylcholine receptor (nAChR) ligand that binds to the agonist-binding site ([3H]-cytisine) with Ki value of 3...
  55. ncbi Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
    Robert S Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurosci 27:10578-87. 2007
    The alpha7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes and may represent a drug target for treating cognitive deficits in neurodegenerative and psychiatric disorders...
  56. pmc Embedded cholesterol in the nicotinic acetylcholine receptor
    Grace Brannigan
    Center for Molecular Modeling, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:14418-23. 2008
    The nicotinic acetylcholine receptor (nAChR) is a cation-selective channel central to both neuronal and muscular processes and is considered the prototype for ligand-gated ion channels, motivating a structural determination effort that ..
  57. doi In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease
    R Scott Bitner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 334:875-86. 2010
    We previously reported that alpha7 nicotinic acetylcholine receptor (nAChR) agonism produces efficacy in preclinical cognition models correlating with activation of cognitive and neuroprotective signaling pathways associated with ..
  58. pmc Upregulation of nuclear factor-kappaB expression by SLURP-1 is mediated by alpha7-nicotinic acetylcholine receptor and involves both ionic events and activation of protein kinases
    Alexander I Chernyavsky
    Department of Dermatology, University of California, Irvine, California 92697, USA
    Am J Physiol Cell Physiol 299:C903-11. 2010
    ..protein-1) is a novel auto/paracrine cholinergic peptide that can bind to α(7)-nicotinic acetylcholine receptor (nAChR), a high Ca(2+)-permeable ion channel coupled to regulation of nuclear factor-κB (NF-κB) expression...
  59. doi Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor
    Theo Dinklo
    Johnson and Johnson Pharmaceutical Research and Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium
    J Pharmacol Exp Ther 336:560-74. 2011
    The α(7) nicotinic acetylcholine receptor (nAChR) is a potential therapeutic target for the treatment of cognitive deficits associated with schizophrenia, Alzheimer's disease, Parkinson's disease, and attention-deficit/hyperactivity ..
  60. ncbi [Opercular epileptic syndrome: an unusual form of benign partial epilepsy in childhood]
    J M Prats
    , Hospital de Cruces, Baracaldo, Vizcaya,
    Rev Neurol 29:375-80. 1999
    ..A third patient suffered benign familial neonatal convulsions (BFNC). In all four patients the actual illness begun as a BECRS with opercular troubles as an ictal phenomena...
  61. ncbi SER252PHE and 776INS3 mutations in the CHRNA4 gene are rare in the Italian ADNFLE population
    M L Tenchini
    Department of Biology and Genetics for Medical Sciences, University of Milan, Italy
    Sleep 22:637-9. 1999
    ..frontal lobe epilepsy (ADNFLE) were analyzed for the presence of two mutations (Ser252Phe, 776ins3) in the CHRNA4 gene, reported to be associated with this disease...
  62. ncbi Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells
    Diane L Carlisle
    Department of Pharmacology, University of Pittsburgh, E1340 Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Pulm Pharmacol Ther 20:629-41. 2007
    Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types, including normal bronchial epithelial cells, and nicotine has been reported to cause Akt activation in cultured normal airway cells...
  63. ncbi [Benign familial neonatal convulsions in a family with one member with infantile spasms]
    K Mori
    Department of Pediatrics, Social Insurance Ritsurin Hospital, Takamatsu
    No To Hattatsu 24:581-6. 1992
    A pedigree of benign familial neonatal convulsions (BFNC) was reported. Seven members of two generations experienced convulsions in the neonatal period and/or in early infancy. All of these members except one had a good prognosis...
  64. ncbi Intravenous anesthetics differentially modulate ligand-gated ion channels
    P Flood
    Department of Anesthesiology, Columbia University, New York, New York 10032, USA
    Anesthesiology 92:1418-25. 2000
    ..Information about the effects of intravenous anesthetics with different behavioral profiles on specific ligand-gated ion channels may lead to hypotheses as to which ion channel effect produces a specific anesthetic behavior...
  65. ncbi Nicotinic and nonnicotinic receptor-mediated actions of vinblastine
    D B McKay
    Division of Pharmacology, College of Pharmacy, Ohio State University, Columbus 43210
    Proc Soc Exp Biol Med 203:372-6. 1993
    Vinblastine has been demonstrated to inhibit nicotinic acetylcholine receptor (nAChR) activity in adrenal chromaffin cells and superior cervical ganglia and to alter agonist binding affinity to nAChR of the electric organ of Torpedo ..
  66. pmc Development and evaluation of evidence-based nursing (EBN) filters and related databases
    Mary A Lavin
    Center for Interprofessional Education and Research, Saint Louis, Missouri 63104, USA
    J Med Libr Assoc 93:104-15. 2005
    Difficulties encountered in the retrieval of evidence-based nursing (EBN) literature and recognition of terminology, research focus, and design differences between evidence-based medicine and nursing led to the realization that nursing ..
  67. ncbi Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors
    Clark A Briggs
    Neuroscience Research, R47W Bldg AP9A 3, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Mol Pharmacol 70:227-40. 2006
    ..Recombinant alpha4beta2 nAChR demonstrate biphasic concentration-response relationships with low- and high-EC50 components...
  68. pmc Biophysical and ion channel functional characterization of the Torpedo californica nicotinic acetylcholine receptor in varying detergent-lipid environments
    Guillermo A Asmar-Rovira
    Departments of Cell Biology and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Membr Biol 223:13-26. 2008
    The nicotinic acetylcholine receptor (nAChR) of Torpedo electric rays has been extensively characterized over the last three decades...
  69. ncbi Monoamine uptake inhibitors block alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation
    Cheng Long
    Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois, USA
    Am J Physiol Heart Circ Physiol 291:H202-9. 2006
    ..axo-axonal interaction hypothesis further by examining whether blocking norepinephrine reuptake enhanced alpha7-nAChR-mediated cerebral nitrergic neurogenic vasodilation...
  70. pmc Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse
    Harald Fischer
    Division of Biochemistry and Molecular Biology, Centre for Brain Research, Medical University Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    J Physiol 563:119-37. 2005
    ..In contrast, DMPP was consistently more potent than cytisine in mice lacking the alpha5 nAChR subunit. Differences in the somatic nAChR rank order of potency were most prominent after a least 1 day in vitro...
  71. pmc Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
    Selvanayagam Nirthanan
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:22051-62. 2008
    ..We report here that TDBzl-etomidate, a photoreactive etomidate analog, acts as a positive allosteric nAChR modulator rather than an inhibitor, and we identify its binding sites by photoaffinity labeling...
  72. ncbi Interactions between tachykinins and diverse, human nicotinic acetylcholine receptor subtypes
    R J Lukas
    Division of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona 85013, USA
    Neurochem Res 21:1245-57. 1996
    Nicotinic acetylcholine receptors (nAChR) are diverse members of the ligand-gated ion channel superfamily of neurotransmitter receptors and play critical roles in chemical signaling throughout the nervous system...
  73. ncbi Interaction of barbiturate analogs with the Torpedo californica nicotinic acetylcholine receptor ion channel
    H R Arias
    Department of Pharmacology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Mol Pharmacol 60:497-506. 2001
    ..One of these superfamilies includes the archetypical nicotinic acetylcholine receptor (nAChR), in which barbiturates act as noncompetitive antagonists...
  74. ncbi Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors
    Alexandre Mourot
    Max Planck Institut fur Biophysik, Frankfurt am Main, Germany
    J Mol Neurosci 30:3-4. 2006
    ..Binding of ACh molecules on the nAChR will trigger the fast opening of the channel and subsequent slow desensitization process...
  75. ncbi Computer modeling of binding of diverse weak toxins to nicotinic acetylcholine receptors
    D Yu Mordvitsev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho Maklaya str, 16 10, GSP 7, 117997 Moscow, Russia
    Comput Biol Chem 31:72-81. 2007
    ..been identified for some of them only, recently by detecting the effects on the nicotinic acetylcholine receptors (nAChR)...
  76. ncbi Nicotinic acetylcholine receptors in autonomic ganglia
    Vladimir I Skok
    Department of Autonomic Nervous System and Physiology, Bogomoletz Institute of Physiology, Kiev, Ukraine
    Auton Neurosci 97:1-11. 2002
    ..autonomic ganglia neurons, the ganglia are strikingly different in the ratio of neurons containing each particular nAChR subunit, as found with immunohistochemical methods and from the analysis of the effects of nAChR subunit-specific ..
  77. ncbi Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor
    Jung Ho Son
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, California 95616 8643, USA
    Biol Reprod 68:1348-53. 2003
    ..Recently, we reported the results of antagonist studies suggesting that a nicotinic acetylcholine receptor (nAChR) containing an alpha7 subunit (alpha7nAChR) plays a role in the human sperm AR initiated by recombinant human ZP3 ..
  78. ncbi Behavioral cross-tolerance between repeated intracerebellar nicotine and acute Delta(9)-tetrahydrocannabinol-induced cerebellar ataxia: role of cerebellar nitric oxide
    Aaron D Smith
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Pharmacol Exp Ther 322:243-53. 2007
    ..N-methyl-4-(3-pyridinyl)-3-buten-1-amine (RJR-2403), a selective alpha(4)beta(2) nicotinic acetylcholine receptor (nAChR) agonist, dose dependently attenuates Delta(9)-tetrahydrocannabinol (Delta(9)THC)-induced ataxia...
  79. pmc Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors
    Man Liu
    Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790, USA
    Anesth Analg 107:525-33. 2008
    ..blocking effects have been observed clinically with certain pairs of nicotinic acetylcholine receptor (nAChR) competitive antagonists. The mechanism for synergy has not been elucidated...
  80. ncbi Direct effects of thymopentin (Arg-Lys-Asp-Val-Tyr) on cholinergic agonist-induced slow inactivation of nicotinic acetylcholine receptor function
    E L Ochoa
    Department of Biochemistry and Biophysics, University of California, Davis 95616
    Mol Pharmacol 38:863-71. 1990
    ..cholinergic agonist-induced inactivation of function (desensitization) of the nicotinic acetylcholine receptor (nAChR) were explored using two systems, 1) Torpedo californica electroplax nAchR reconstituted into phospholipid ..
  81. ncbi Statins prevent cholinesterase inhibitor blockade of sympathetic alpha7-nAChR-mediated currents in rat superior cervical ganglion neurons
    Mansoor Mozayan
    Department of Pharmacology, Southern Illinois University School of Medicine, PO Box 19629 Springfield, IL 62794 9629, USA
    Am J Physiol Heart Circ Physiol 293:H1737-44. 2007
    ..We recently reported that alpha7-neuronal acetylcholine nicotinic receptor (alpha7-nAChR)-mediated neurogenic vasodilation of porcine cerebral arteries was blocked by ChEIs, and this blockade was ..
  82. ncbi Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse
    D G Drescher
    Department of Otolaryngology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112:267-73. 1995
    ..The current results indicate that nicotinic acetylcholine receptor (nAChR) subunits that are similar or identical to the stated muscle and neuronal types are expressed in the murine ..
  83. ncbi Effect of dimethoate on the function and expression of nicotinic acetylcholine receptor in primary skeletal muscle cell culture
    D Yang
    Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97201, USA
    In Vitr Mol Toxicol 14:241-5. 2001
    ..representative organophosphate dimethoate on the function and expression of the nicotinic acetylcholine receptor (nAChR) in primary skeletal muscle cell culture...
  84. ncbi A novel KCNQ2 K+ channel mutation in benign neonatal convulsions and centrotemporal spikes
    G Coppola
    Department of Child Neuropsychiatry, 2nd University of Naples, Italy
    Neurology 61:131-4. 2003
    Patients with benign familial neonatal convulsions (BFNC) may develop various epilepsies or epilepsy-associated EEG traits...
  85. ncbi Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning
    Diana S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    Behav Brain Res 143:159-67. 2003
    The aim of this experiment was to investigate the effects of nicotinic acetylcholine receptor (nAChR) agonism and antagonism on learning...
  86. ncbi Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines
    Lorise C Gahring
    Geriatric Research, Education and Clinical Center, Salt Lake City VA, Salt Lake City, UT 84132, USA
    J Neurochem 87:1125-36. 2003
    ..different toxins is imparted through pharmacologically distinct neuronal nicotinic acetylcholine receptors (nAChR) where protection against chronic N-methyl-d-aspartic acid (NMDA) exposure is through nAChRalpha7 but protection ..
  87. ncbi DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells
    Pei Shan Liu
    Department of Microbiology, Soochow University, Shihlin, Taipei, Taiwan, ROC
    J Biomed Sci 11:200-5. 2004
    ..catecholamine secretion and cytosolic Ca(2+) ([Ca(2+)](i)) rise coupled with nicotinic acetylcholine receptor (nAChR) without exerting an effect on (3)H-nicotine binding...
  88. ncbi Imaging of central nAChReceptors with 2-[18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease
    J Schmaljohann
    Department of Neurology, University of Bonn, 53105 Bonn, Germany
    Appl Radiat Isot 61:1235-40. 2004
    In vivo labeling of the nicotinic acetylcholine receptors (nAChR) could be a useful tool for early diagnosis of neurodegenerative disorders...
  89. ncbi Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells
    Dominik Feuerbach
    Neuroscience Research, Novartis Institutes for BioMedical Research, CH 4002 Basel, Switzerland
    Neuropharmacology 48:215-27. 2005
    The neuronal nicotinic acetylcholine receptor alpha7 (nAChR alpha7) may be involved in cognitive deficits in Schizophrenia and Alzheimer's disease...
  90. pmc Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways
    Piyali Dasgupta
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA
    J Clin Invest 116:2208-2217. 2006
    ..The mitogenic effects of nicotine were mediated via the alpha7-nAChR subunit and resulted in enhanced recruitment of E2F1 and Raf-1 on proliferative promoters in NSCLC cell lines and ..
  91. ncbi Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade
    Malin Jonsson
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital and Karolinska Institutet, Sweden
    Anesthesiology 105:521-33. 2006
    ..Their primary site of action is at the postsynaptic nicotinic acetylcholine receptor (nAChR) in the neuromuscular junction, but their action on neuronal nAChRs have not been fully evaluated...
  92. ncbi A major role of the nicotinic acetylcholine receptor gene CHRNA2 in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is unlikely
    Wenli Gu
    Institute of Human Genetics, University Hospital, University of Munich, Goethestr 29, 80336 Munich, Germany
    Neurosci Lett 422:74-6. 2007
    ..be caused by mutations in the transmembrane regions of the neuronal nicotinic acetylcholine receptor (nAChR) genes CHRNA4 and CHRNB2...
  93. ncbi Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
    Philip J Welsby
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuropharmacology 53:188-95. 2007
    ..The enhancing action of nicotine was mediated via alpha7 nAChRs as it was absent in mice null for alpha7 nAChR. Abeta strongly inhibited the induction of LTP in control animals, with LTP being completely inhibited at 1h post-..
  94. ncbi Functional interactions between the SK2 channel and the nicotinic acetylcholine receptor in enteric neurons of the guinea pig ileum
    Hidemitsu Nakajima
    Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Science, Osaka Prefecture University, Naka ku, Sakai, Japan
    J Neurochem 103:2428-38. 2007
    ..for choline acetyltransferase, a marker for cholinergic neurons, and with an antibody for the alpha3/5 subunits of nAChR. In contrast, immunoreactivity of SK3 subunits was not found in enteric neurons...
  95. doi Attenuation of ethanol-induced ataxia by alpha(4)beta(2) nicotinic acetylcholine receptor subtype in mouse cerebellum: a functional interaction
    N Taslim
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    Neuroscience 157:204-13. 2008
    ..The present study was designed to determine the possible involvement of specific nicotinic acetylcholine receptor (nAChR) subtype alpha(4)beta(2) in nicotine-induced attenuation of ethanol ataxia...
  96. doi Time-dependent alterations of cholinergic markers after experimental traumatic brain injury
    Cornelius K Donat
    Institute of Interdisciplinary Isotope Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Brain Res 1246:167-77. 2008
    ..Time-dependent reductions of about 20% of nAChR-density in the thalamus, hypothalamus, olfactory tubercle, gigantocellular reticular nucleus and motor cortex were ..
  97. pmc Nicotinic acetylcholine receptor subunits in rhesus monkey retina
    Ji Liu
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6075, USA
    Invest Ophthalmol Vis Sci 50:1408-15. 2009
    The purpose of this study was to detect and establish the cellular localizations of nicotinic acetylcholine receptor (nAChR) subunits in Rhesus monkey retina.
  98. doi Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB
    Mario B Marrero
    Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    Brain Res 1256:1-7. 2009
    Our laboratories have previously identified the alpha7 nAChR-JAK2 pathway as playing a central role in nicotine-induced neuroprotection...
  99. pmc Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction
    Anitha P Govind
    Department of Neurobiology, University of Chicago, Abbot Hall 402 MC0926, Chicago, IL 60637, USA
    Biochem Pharmacol 78:756-65. 2009
    ..molecular biology of nicotine addiction has been characterizing the different nicotinic acetylcholine receptor (nAChR) subtypes in the brain and how nicotine alters their function...
  100. pmc [(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel
    David C Chiara
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 48:10066-77. 2009
    Chlorpromazine (CPZ), a potent nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist, binds with higher affinity in the ion channel in the desensitized state than in the closed channel state and with low affinity to ..
  101. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..The beta(2)*-containing nicotinic acetylcholine receptor (beta(2)*-nAChR) has recently emerged as a prime candidate because some alpha and beta subunit genes have been linked to alcohol ..

Research Grants65

  1. Nicotine Addiction: ACh Receptors and Secretion
    Aaron Fox; Fiscal Year: 2002
    ..there is a growing body of evidence pointing to the involvement of high-affinity neuronal nicotinic receptors (nAChR) in addiction. Our project will explore possible mechanisms that underlie nicotine addiction...
  2. Eliot R Spindel; Fiscal Year: 2015
    ..of lung cancers are associated with smoking and most lung cancers express nicotinic acetylcholine receptors (nAChR) that are activated by the nicotine in cigarette smoke...
  3. Interventions to Test the alpha 7 Nicotinic Receptor Model in Schizophrenia
    Stephen Deutsch; Fiscal Year: 2009
    ..The hypothesis of alpha-7 nicotinic acetylcholine receptor (a7 nAChR) hypofunction is based on the prevalence of smoking in schizophrenia, receptor binding data on autopsied brain, ..
  4. Maurizio Fava; Fiscal Year: 2015
    ..In so doing, we will discover if the selective alpha-7 nAChR agonist improves cognitive performance during nicotine taper and in early abstinence and if this effect is ..
  5. Mechanisms of nicotine-mediated decrease in L-dopa induced-dyskinesias
    Maryka Quik; Fiscal Year: 2013
    ..This work will provide a basis for the studies in Aim 3 to test the effect of nAChR subtype agonists for their antidyskinetic properties...
  6. The Neuronal alpha-bungarotoxin Binding Site
    WILLIAM NATHAN GREEN; Fiscal Year: 2012
    ..proposal, we will study the regulation of the expression of a specific neuronal nicotinic acetylcholine receptor (nAChR) subtype, the [unreadable]-bungarotoxin binding receptor (BgtR), which is an ionotropic neurotransmitter receptor...
  7. Role of calcium-dependent mechanisms in nicotine's tolerance and effects
    MOHAMAD IMAD DAMAJ; Fiscal Year: 2010
    ..antagonists and different nAChRs transgenic mice will be carried out in order to test the hypothesis that a4b2* nAChR subtypes mediate nicotine's effects on CaMKII activity in the VTA...
  8. SNRP Program at UCC
    Maria Bykhovskaia; Fiscal Year: 2012
    ..will address the issues of oxidative damage in Huntington disease, direct effects of thyroid hormones on the nAChR and on synapse remodelling, and modulation of potassium channels by spermine...
  9. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..It is further hypothesized that cholinergic neurons expressing the alpha-5 nicotinic acetylcholine receptor (nAChR) subunit modulate information processing within the IPN-DTN pathway and that information is subsequently relayed ..
  10. Alessandro Guidotti; Fiscal Year: 2015
    ..of the brain of SZ patients reveals: a) a decrease of high and low affinity nicotinic acetylcholine receptor (nAChR) subtypes in telencephalic GABAergic neurons, which is possibly alleviated by nicotine abuse, and b) a ..
  11. Hybrid atomic force-optical imaging system to investigate prenatal nicotine
    Jeffrey Potts; Fiscal Year: 2009
    Neuronal nicotinic acetylcholine receptors (nAchR) are targets for the neurotransmitter acetylcholine and exogenous cholinergic ligands such as nicotine from cigarette smoke...
  12. John McDaid; Fiscal Year: 2015
    ..17 nAChR inhibitors suppress locomotion and cognitive functions and our preliminary data indicates that 17 nAChRs in the ..
  13. Henry A Lester; Fiscal Year: 2014
    ..Now five linked sub- hypotheses will be tested about the cellular and subcellular details of alpha4beta2 nAChR upregulation in the VTA and NAcc...
  14. Ethanol Regulation of Neuronal Nicotinic Receptor Expression in Reward Circuitry
    Andrew R Tapper; Fiscal Year: 2010
    ..In addition, ethanol has been shown to directly either potentiate or inhibit the nAChR response to ACh depending on the subunit composition of the receptor...
  15. The Role of Nicotinic Receptors in Nicotine Withdrawal
    Andrew R Tapper; Fiscal Year: 2010
    ..nicotine dependence and withdrawal have lead to a better understanding of nicotine addiction;however the specific nAChR subtypes involved in withdrawal symptoms are not fully elucidated...
  16. ACETYLCHOLINE RECEPTOR BIOGENESIS, STRUCTURE, FUNCTION
    Edward Hawrot; Fiscal Year: 2009
    ..Classical approaches to discern functionally significant neuronal nAChR subtypes in the central nervous system (CNS) have been frustrated by the limited number of selective ..
  17. Andrew R Tapper; Fiscal Year: 2016
    ..have been implicated in the reinforcing properties of ethanol, but, despite this association, the specific nAChR subtypes mediating these effects are unknown...
  18. Effects of nicotine and varenicline on ethanol behaviors
    Noah R Gubner; Fiscal Year: 2013
    ..One explanation for the co-abuse of these two drugs is that nicotinic acetylcholine receptors (nAChR) may represent a common site of action for ethanol and nicotine...
  19. William Green; Fiscal Year: 2016
    ..We have demonstrated that nAChR upregulation is much more complex than originally assumed consisting of multiple processes that occur at very ..
  20. Mechanisms of TNFa Enhancement of Nicotinic Receptor Upregulation
    SCOTT WARREN ROGERS; Fiscal Year: 2013
    ..imparts its effects on cellular function through interaction with neuronal nicotinic acetylcholine receptors (nAChR)...
  21. Dose ranging study of varenicline on human alcohol self-administration behavior
    SHERRY ANN MCKEE; Fiscal Year: 2011
    ..Given the strong evidence that the nicotinic acetylcholine receptor (nAChR) system is involved in modulating alcohol effects and consumption, this system holds promise as a viable target ..
  22. Mecamylamine for the Treatment of Alcohol Dependence
    Ismene L Petrakis; Fiscal Year: 2012
    ..In fact, acetylcholine nicotinic receptors (nAChR), which are important in nicotine dependence may also play a crucial role in alcohol dependence...
  23. Marina R Picciotto; Fiscal Year: 2015
    ..have also found that human depressed subjects show decreased occupancy of high affinity nAChRs with no change in nAChR number, suggesting that increased ACh levels may contribute to human depression...
  24. Arthur Brody; Fiscal Year: 2016
    ..for this grant application, the primary hypothesis for the proposed research are that: 1) pre-treatment 1422* nAChR densities in the thalami (and other brain regions of interest) will be higher in menthol than non-menthol ..
  25. KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATION
    PALMER WILLIAM TAYLOR; Fiscal Year: 2013
    ..have evolved from considerations of structure and function of AChE and the nicotinic acetylcholine receptor (nAChR) and, more recently, from AChE to a related a/b-hydrolase fold protein, neuroligin...
  26. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..as well as EGFR, and since tumor cells derived from these tissues actively divide and invade in response to nAChR and EGFR signaling, we hypothesize that there might be common mediators of these signals in smokers and non-..
  27. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..delivery of smoking cessation treatment by determining if pre-treatment 1422* nicotinic acetylcholine receptor (nAChR) density in cigarette smokers is associated with smoking cessation outcome with the standard nicotine patch taper...
  28. Roger L Papke; Fiscal Year: 2016
    ..We will use our new discoveries about how these drugs work to help make alpha7-stimulating drugs optimally designed to treat specific diseases. ..
  29. Novel lead molecule optimization targeting nicotinic receptor subtypes
    DENNIS BRIAN contact MCKAY; Fiscal Year: 2010
    ..Our target is the neuronal nicotinic acetylcholine receptor (nAChR)...
  30. Models for?functional evaluation of?CHRN polymorphisms
    Beverly H Koller; Fiscal Year: 2012
    ..b>nAChR are ligand gated ion channels, composed of various combinations of five subunit proteins, encoded by 11 different ..
  31. Paul D Gardner; Fiscal Year: 2014
    ..Interestingly, these three nAChR genes are tightly clustered in the genome (in the order CHRNA5/A3/B4 relative to the centromere) and their ..
  32. Alpha5 Subunits in Alpha4beta2 Nicotinic Receptors: Assembly and Function
    CRYSTAL N DILWORTH; Fiscal Year: 2012
    ..resonance energy transfer (FRET) and total internal reflection fluorescence (TIRF) we are able to visualize the nAChR's life cycle from assembly to degradation, within living cells...
  33. Dissecting the Cytoplasmic Interactome of the Alpha7 nACHR Subtype
    WILLIAM J BRUCKER; Fiscal Year: 2013
    ..The goals of this study are to discover the cytoplasmic interactome of the a7 nicotinic acetylcholine receptor (nAChR) subtype and how this interactome is altered by chronic nicotine exposure...
  34. The rodent continuous performance task: Filling the vigilance translational gap
    JARED WILLIAM YOUNG; Fiscal Year: 2010
    ..Acute and sub-chronic treatment studies will examine whether the 17 nicotinic acetylcholine receptor (nAChR) is necessary for nicotine-induced enhancement of vigilance by comparing the effects of nicotine on mutant mice ..
  35. Maternal smoking and hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2010
    ..in the hippocampus, a brain region associated with memory formation, via sustained activation of a specific nAChR subtype on interneurons, resulting in a long-lasting disturbance of circuit operation...
  36. High Throughput Screening for nAChRs: Cell Lines and Assay Development
    Yingxian Xiao; Fiscal Year: 2011
    ..For many years, a4b2 nAChR subtypes (composed of a4, b2 and perhaps other subunits) have been the primary focus for studying nicotine ..
  37. Vijay Lyall; Fiscal Year: 2016
    ..The overall aim of this study is to increase our understanding of the contribution of different nAChR subunits to the bitter taste of nicotine, acetylcholine, ethanol and other bitter compounds...
  38. Role of Habenula in Tobacco Addiction
    Ramiro Salas; Fiscal Year: 2013
    ..I had a postdoctoral experience in which I worked on mice with mutations on nicotinic receptors (nAChR), using behavior, in vivo pharmacology, microdialysis, etc...
  39. Development of Novel Drugs for Smoking Cessation Pharmacotherapy
    Nurulain T Zaveri; Fiscal Year: 2012
    ..our novel series of very potent and highly selective [unreadable]3[unreadable]4 nicotinic acetylcholine receptor (nAChR) ligands, for further translational development into smoking cessation medications...
  40. Ronald J Lukas; Fiscal Year: 2014
    ..these disorders, this project seeks to identify roles in them played by nicotinic acetylcholine receptors (nAChR), specifically, those containing [unreadable]9 subunits ([unreadable]9*-nAChR)...
  41. GENETICS OF NICOTINE TOLERANCE: ROLE OF RECEPTORS
    Michael J Marks; Fiscal Year: 2013
    ..a number of genetic markers which correlate with aspects of smoking behavior and that correspond to different nAChR subunits...
  42. Lynx in organization and dynamics of nicotinic acetylcholine receptor complexes
    Julie M Miwa; Fiscal Year: 2013
    ..Localization in synaptic vs extrasynaptic areas is also a crucial aspect of nAChR function. Lynx proteins are widely expressed regulators of nicotinic receptor function...
  43. Imaging varenicline effects on nicotine & dopamine: Gene modulation
    Gary S Wand; Fiscal Year: 2010
    ..Specific polymorphisms in nAChR subunit genes have been associated with ND and other nicotine phenotypes...
  44. VTA Nicotinic Receptors in Alcohol Preference and Reward
    LINZY MARIN HENDRICKSON; Fiscal Year: 2010
    ..like nicotine, activates nAChRs within the mesolimbic reward pathway [3], however, because of the diversity of nAChR subunits expressed within the brain's DAergic reward pathway, an important goal of alcohol research is ..
  45. Dana B Hancock; Fiscal Year: 2015
    ..identified associations with single nucleotide polymorphisms (SNPs) spanning the nicotinic acetylcholine receptor (nAChR) genes on chromosome 15q25 (CHRNA5-CHRNA3-CHRNB4) and on chromosome 8p11 (CHRNB3- CHRNA6)...
  46. Tobacco Smoking, Genes &Nicotinic Receptors
    Kelly P Cosgrove; Fiscal Year: 2013
    ..The nicotinic acetylcholine receptor (nAChR) is the initial site of action of nicotine, the addictive chemical constituent of tobacco smoke and thus, is a ..
  47. BRANDON JARROD HENDERSON; Fiscal Year: 2014
    ..will be used to identify cells with abundant ER exit sites which are a marker for high levels of alpha6beta2beta3 nAChR expression on the plasma membrane...
  48. Kelly P Cosgrove; Fiscal Year: 2016
    ..The focus is on 2 genes that have been associated with nicotine dependence, the CHRNA4 and ANKK1...
  49. Paul Whiteaker; Fiscal Year: 2014
    ..Aims, Significance and Innovation sections, this proposal will provide a set of validated assays targeting nAChR subtypes tied to use of, and dependence on, tobacco products...
  50. Henry A Lester; Fiscal Year: 2014
    ..successful smoking cessation compounds can selectively target just one or a few nicotinic acetylcholine receptor (nAChR) combinations. Nicotine addiction begins with the activation of these receptors, which are ligand-gated channels...
  51. Role of Brain Nicotinic Receptors in Addiction Behaviors
    STEPHEN FOX HEINEMANN; Fiscal Year: 2010
    ..Initial exposure to nicotine activates nAChRs, but chronic exposure depresses nAChR function (desensitization)...
  52. Allosteric Potentiation of Neuronal Nicotinic Receptors
    Mark M Levandoski; Fiscal Year: 2010
    ..the paradigm of activation of nAChRs by occupying two agonist binding sites: We are studying a previously unknown nAChR ligand binding site, and the work we propose stands to substantially strengthen the foundation for rational design ..
  53. INSECTICIDE ACTIONS ON NICOTINIC ACETYLCHOLINE RECEPTORS
    Gustav Akk; Fiscal Year: 2011
    The nicotinic acetylcholine receptor (nAChR) is the target of synthetic, nicotine-based insecticides, called neonicotinoids...
  54. Characterizing Alpha5* Nicotinic Receptors in Alcohol and Nicotine Co-Dependence
    Raymond L White; Fiscal Year: 2010
    ..of human genetic association studies have implicated the neuronal nicotinic receptors (nAChRs), such as the a5 nAChR subunit as playing a critical role in developing alcohol and nicotine dependence processes and recent molecular ..
  55. Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
    RYAN MICHAEL DRENAN; Fiscal Year: 2010
    ..experiments, I designed and built a set of novel transgenic mouse lines to particularly isolate aspects of 16 nAChR biology...
  56. Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
    RYAN MICHAEL DRENAN; Fiscal Year: 2013
    ..I designed and built a set of novel transgenic mouse lines to particularly isolate aspects of [unreadable]6 nAChR biology...
  57. Translational studies of nicotinic receptor genes: alcohol and nicotine behaviors
    Marissa A Ehringer; Fiscal Year: 2013
    ..Recent work has provided evidence that several of the human nAChR subunit genes are associated with alcohol and nicotine behaviors in humans, including age of initiation, early ..
  58. Dopaminergic Neurons from Pluripotent Stem Cells for Substance Abuse Research
    Pietro P Sanna; Fiscal Year: 2012
    ..to be associated with addiction;the nicotinic subunit receptor genes in the CHRNA3-CHRNB4-CHRNA5 region as well as CHRNA4 and CHRNA6, the A118G polymorphism of the [unreadable] opioid receptor OPRM1, and mutations in the TTC12-ANKK1- ..
  59. Joao A Paulo; Fiscal Year: 2016
    ..the effects of nicotine on the phosphoprotein alterations of PaSC in efforts to identify 1) nicotinic receptor (nAChR) subunits expressed by PaSC and assess their roles in fibrosis, 2) differences in the kinase activity profiles of ..
  60. Mice with Functional Fluorescent Nicotinic Receptor Subunits
    Henry A Lester; Fiscal Year: 2010
    ..will generate and validate fourteen strains of mice with fully functional fluorescent mouse nicotinic receptor (nAChR) subunits...
  61. Russell W Brown; Fiscal Year: 2015
    ..nicotine sensitization and place conditioning in neonatal quinpirole-treated rats is mediated by the [unreadable]7 nAChR, and the [unreadable]7 nAChR antagonist MLA will reduce nicotine-induced increased of BDNF and p-CREB protein in ..
  62. Variants in CHRNA5/CHRNA3/CHRNB4 and nicotine dependence
    Xiangning Chen; Fiscal Year: 2010
    ..functional and pharmacological effects of the presence of wild-type or D398N a5 subunits on a4b2*- and a3b4*-nAChR using patch-clamp technique. 3...
  63. Pharmacology and Regulation of Nicotinic Receptor Subtypes
    Kenneth J Kellar; Fiscal Year: 2012
    ..are to assess the pharmacology and regulation of the diverse heteromeric neuronal nicotinic cholinergic receptor (nAChR) subtypes in the mammalian central nervous system (CNS)...
  64. Development of Pharmacotherapies for Nicotine Addiction
    Frank Carroll; Fiscal Year: 2009
    ..and in vivo pharmacological studies also indicate bupropion is an antagonist of nicotinic acetylcholine receptors (nAChR), with the a4[unreadable]2 nAChR subtype identified as the most relevant...
  65. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2004
    ..will make use of transgenic mice lacking the Beta 2 subunit of the neuronal nicotinic acetylcholine receptor (nAChR) that no longer have any high affinity nicotine binding sites in the brain, to determine the role of the high ..