CHRDL1

Summary

Gene Symbol: CHRDL1
Description: chordin like 1
Alias: CHL, MGC1, MGCN, NRLN1, VOPT, dA141H5.1, chordin-like protein 1, neuralin-1, neurogenesin-1, ventroptin
Species: human

Top Publications

  1. pmc Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury
    Barry W Larman
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Am Soc Nephrol 20:1020-31. 2009
  2. doi Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells
    Hugo Fernandes
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Cells Tissues Organs 191:443-52. 2010
  3. pmc Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis
    Rosemary Kane
    School of Medicine and Medical Science, UCD Conway Institute and UCD Diabetes Research Centre, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Vis 14:1138-48. 2008
  4. ncbi X-linked megalocornea: close linkage to DXS87 and DXS94
    J D Chen
    Department of Clinical Chemistry, Prince of Wales Hospital, Randwick, Australia
    Hum Genet 83:292-4. 1989
  5. ncbi Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate
    C Coffinier
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
    Mech Dev 100:119-22. 2001
  6. ncbi Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina
    H Sakuta
    Division of Molecular Neurobiology, National Institute for Basic Biology, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji cho, Okazaki 444 8585, Japan
    Science 293:111-5. 2001
  7. pmc X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development
    Tom R Webb
    Institute of Ophthalmology, University College London, UK
    Am J Hum Genet 90:247-59. 2012
  8. ncbi Localization and orientation of subunit delta of spinach chloroplast ATP-synthase within the CF0 CF1 complex. 2. Identification of C-terminal residues of delta, exposed on the thylakoid membrane
    R J Berzborn
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 44:480-6. 1989
  9. ncbi Bioaccumulation of PCBs and chlorinated pesticides in seals, fishes and invertebrates from the White Sea, Russia
    Derek Muir
    National Water Research Institute, Environment Canada, Burlington, ON, Canada L7R 4A6
    Sci Total Environ 306:111-31. 2003
  10. ncbi Humoral factors released during trauma of Aplysia body wall. I. Body wall contraction, cardiac modulation, and central reflex suppression
    J K Krontiris Litowitz
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    J Comp Physiol B 159:211-23. 1989

Research Grants

  1. MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS
    George Bailey; Fiscal Year: 1999
  2. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2000
  3. CRYSTAL STUDIES OF LIGHT-HARVESTING CHL A/B COMPLEX
    Mary Lyon; Fiscal Year: 1992
  4. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
  5. Hideko Heidi Nakajima; Fiscal Year: 2016
  6. Glycoproteins and Glycan-Binding IgGs: Biomarkers for Cancer and Inflammatory Di
    Hyesook Kim; Fiscal Year: 2013
  7. Daniel J Tollin; Fiscal Year: 2016
  8. DAN HARVEY SANES; Fiscal Year: 2015
  9. Daniel B Polley; Fiscal Year: 2016
  10. Margaret A Shipp; Fiscal Year: 2016

Detail Information

Publications216 found, 100 shown here

  1. pmc Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury
    Barry W Larman
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    J Am Soc Nephrol 20:1020-31. 2009
    ..As regenerating epithelia differentiate, Chordin-like 1 is again expressed, antagonizing BMP7. These data suggest a mechanism for dynamic regulation of renoprotective BMP7 signaling in the S3 segment of the proximal tubule...
  2. doi Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells
    Hugo Fernandes
    Department of Tissue Regeneration, University of Twente, Enschede, The Netherlands
    Cells Tissues Organs 191:443-52. 2010
    ..Our data point towards a novel, BMP-independent role of chordin-like 1 in hMSC proliferation...
  3. pmc Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis
    Rosemary Kane
    School of Medicine and Medical Science, UCD Conway Institute and UCD Diabetes Research Centre, University College Dublin, Belfield, Dublin 4, Ireland
    Mol Vis 14:1138-48. 2008
    ..This study investigated the effects of hypoxia on retinal pericyte gene expression, and demonstrates a role in angiogenesis regulation for the hypoxia driven gene, chordin-like 1 (CHL-1).
  4. ncbi X-linked megalocornea: close linkage to DXS87 and DXS94
    J D Chen
    Department of Clinical Chemistry, Prince of Wales Hospital, Randwick, Australia
    Hum Genet 83:292-4. 1989
    ..In a family in which X-linked megalocornea is segregating, the disease locus was found to be closely linked to DXS87 (zeta max = 3.91, theta max = 0.00) and DXS94 (zeta max = 3.34, theta max = 0.00) in Xq21.3-q22...
  5. ncbi Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate
    C Coffinier
    Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095 1662, USA
    Mech Dev 100:119-22. 2001
    ..During organogenesis, neuralin-1 presents a broad expression pattern in many tissues such as dorsal root ganglia, gut, condensing cartilages of the skeleton and developing hair follicles...
  6. ncbi Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina
    H Sakuta
    Division of Molecular Neurobiology, National Institute for Basic Biology, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji cho, Okazaki 444 8585, Japan
    Science 293:111-5. 2001
    ..We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not ..
  7. pmc X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development
    Tom R Webb
    Institute of Ophthalmology, University College London, UK
    Am J Hum Genet 90:247-59. 2012
    ..CHRDL1 encodes ventroptin, a bone morphogenic protein antagonist with a proposed role in specification of topographic retinotectal ..
  8. ncbi Localization and orientation of subunit delta of spinach chloroplast ATP-synthase within the CF0 CF1 complex. 2. Identification of C-terminal residues of delta, exposed on the thylakoid membrane
    R J Berzborn
    , , , Bundesrepublik Deutschland
    Z Naturforsch C 44:480-6. 1989
    ..Since trypsin destroys this epitope only after prolonged incubation and with at least 50 micrograms trypsin/mg Chl, residue Lys169 of delta probably is inaccessible in situ...
  9. ncbi Bioaccumulation of PCBs and chlorinated pesticides in seals, fishes and invertebrates from the White Sea, Russia
    Derek Muir
    National Water Research Institute, Environment Canada, Burlington, ON, Canada L7R 4A6
    Sci Total Environ 306:111-31. 2003
    ..including polychlorinated biphenyl (PCB) congeners, Dichlorophenyltrichloroethane (DDT)- and chlordane (CHL) related compounds, hexachlorocyclohexanes (HCH) isomers and chlorobenzenes (CBz) were determined in blubber of ..
  10. ncbi Humoral factors released during trauma of Aplysia body wall. I. Body wall contraction, cardiac modulation, and central reflex suppression
    J K Krontiris Litowitz
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    J Comp Physiol B 159:211-23. 1989
    ..hemolymphh, SHL) caused long-lasting contractions which were larger than those produced by control hemolymph (CHL) collected prior to stimulation of the donor. 6...
  11. ncbi The action of oxygen on chlorophyll fluorescence quenching and absorption spectra in pea thylakoid membranes under the steady-state conditions
    Maciej Garstka
    Department of Metabolic Regulation, Institute of Biochemistry, Faculty of Biology, Warsaw University, Miecznikowa 1, PL 02 096 Warszawa, Poland
    J Photochem Photobiol B 77:79-92. 2004
    ..Simultaneously, an increase in oxygen concentration resulted in a decline in the Chl fluorescence at 680 nm to about 60% of the initial value...
  12. pmc Ultrafast transient absorption studies on photosystem I reaction centers from Chlamydomonas reinhardtii. 2: mutations near the P700 reaction center chlorophylls provide new insight into the nature of the primary electron donor
    Alfred R Holzwarth
    Max Planck Institut fur Bioanorganische Chemie, D 45470 Mulheim an der Ruhr, Germany
    Biophys J 90:552-65. 2006
    ..is slowed down by a factor of approximately 2 in the mutant B-H656C, which lacks the ligand to the central metal of Chl PB...
  13. ncbi Quantitative analysis of the effects of intrathylakoid pH and xanthophyll cycle pigments on chlorophyll a fluorescence lifetime distributions and intensity in thylakoids
    A M Gilmore
    Photobioenergetics Group, Australian National University Research School of Biological Sciences, Canberra, ACT
    Biochemistry 37:13582-93. 1998
    ..we studied the influence of the intrathylakoid pH and the xanthophyll cycle carotenoids on the PSII chlorophyll (Chl) a fluorescence yield in thylakoids of Arabidopsis, spinach, and barley...
  14. ncbi Effects of enhanced UV-B on pigment-based phytoplankton biomass and composition of mesocosm-enclosed natural marine communities from three latitudes
    Suzanne Roy
    Institut des Sciences de la Mer ISMER, Universite du Quebec a Rimouski, Canada
    Photochem Photobiol 82:909-22. 2006
    ..with time as the repeated factor, showed slight but statistically significant increases in the chlorophyll (Chl) a level with the HUVB treatment, which were especially obvious over the last 3 days of the experiment...
  15. ncbi Anacystis mutants with different tolerances to DCMU-type herbicides show differences in architecture and dynamics of the photosynthetic apparatus, depending on site and mode of the amino acid exchanges in the D 1 protein
    F Koenig
    , Frankfurt am Main, Bundesrepublik Deutschland
    Z Naturforsch C 45:446-51. 1990
    ..Not only the molar ratio of phycocyanin (PC) to chlorophyll (Chl) is higher in all mutants compared to the respective wild type, but also the rate of synthesis of the D 1 protein...
  16. ncbi Polymorph farming of acetaminophen and sulfathiazole on a chip
    Tu Lee
    Department of Chemical and Materials Engineering, National Central University, 300 Jhong Da Rd, Jhong Li 320, Taiwan, Republic of China
    Pharm Res 23:2542-55. 2006
    ....
  17. ncbi Effect of chlorophyllin-chitosan on excretion of dioxins in a healthy man
    Kimiyoshi Kitamura
    National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Environ Sci Technol 39:1084-91. 2005
    We investigated the usefulness of chitosan and chlorophyllin-chitosan (chl-chitosan) administration for reduction of the body burden of environmental dioxins, including polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDDs/ Fs) and ..
  18. ncbi The effect of type of delivery and povidone-iodine application at delivery on cord dried-blood-specimen thyrotropin level and the rate of hyperthyrotropinemia in mature and normal-birth-weight neonates residing in an iodine-replete area: report of Tehran
    Arash Ordookhani
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Thyroid 17:1097-102. 2007
    ..To evaluate the effects of delivery type and of povidone-iodine disinfection at delivery on cord dried-blood-specimen (DBS) thyrotropin (TSH) concentrations...
  19. pmc Antagonistic actions of boron against inhibitory effects of aluminum toxicity on growth, CO2 assimilation, ribulose-1,5-bisphosphate carboxylase/oxygenase, and photosynthetic electron transport probed by the JIP-test, of Citrus grandis seedlings
    Huan Xin Jiang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China
    BMC Plant Biol 9:102. 2009
    ..6H2O). The objectives of this study were to determine how B alleviates Al-induced growth inhibition and to test the hypothesis that Al-induced photosynthesis inhibition can be alleviated by B via preventing Al from getting into shoots...
  20. ncbi Chlorogenic acid analogue S 3483: a potent competitive inhibitor of the hepatic and renal glucose-6-phosphatase systems
    W J Arion
    Division of Nutritional Sciences, Cornell University, Ithaca, New York, 14853, USA
    Arch Biochem Biophys 351:279-85. 1998
    S 3483, a synthetic derivative of chlorogenic acid (CHL), was found to be a reversible, linear competitive inhibitor of the glucose-6-phosphatase (Glc-6-Pase) system in rat renal microsomes and rat and human liver microsomes...
  21. ncbi Interaction of exogenous quinones with membranes of higher plant chloroplasts: modulation of quinone capacities as photochemical and non-photochemical quenchers of energy in Photosystem II during light-dark transitions
    Nikolai G Bukhov
    Departement de Chimie Biologie, Groupe de Recherche en Energie et Information Biomoléculaires, Universite du Quebec a Trois Rivieres, Canada
    Biochim Biophys Acta 1604:115-23. 2003
    ..DBMIB), 2,6-dichloro-p-benzoquinone (DCBQ), and tetramethyl-p-benzoquinone (duroquinone), to quench chlorophyll (Chl) fluorescence photochemically or non-photochemically was studied to simulate the functions of endogenous ..
  22. pmc Conductive hearing loss caused by third-window lesions of the inner ear
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Division of Health Sciences and Technology, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts 02114, USA
    Otol Neurotol 29:282-9. 2008
    Various authors have described conductive hearing loss (CHL), defined as an air-bone gap on audiometry, in patients without obvious middle ear pathologic findings...
  23. doi A novel insight into the regulation of light-independent chlorophyll biosynthesis in Larix decidua and Picea abies seedlings
    Viktor Demko
    Department of Plant Physiology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovakia
    Planta 230:165-76. 2009
    Light-independent chlorophyll (Chl) biosynthesis is a prerequisite for the assembly of photosynthetic pigment-protein complexes in the dark. Dark-grown Larix decidua Mill...
  24. pmc Whole cell and single channel analysis of the kinetics of glycine-sensitive N-methyl-D-aspartate receptor desensitization
    C G Parsons
    Department of Neurophysiology, Max Planck Institute for Psychiatry, Planegg Martinsried, Germany
    Br J Pharmacol 109:213-21. 1993
    ..8. The glycineB antagonist 7-chlorokynurenic acid (7-Chl-Kyn 3 and 10 microM) concentration-dependently induced an identical form of desensitization in the presence of 1 ..
  25. doi Video pneumatic otoscopy for the diagnosis of conductive hearing loss with normal tympanic membranes
    Jae Kwon Lee
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Otolaryngol Head Neck Surg 144:67-72. 2011
    To evaluate the usefulness of video pneumatic otoscopy (VPO) for the diagnosis of conductive hearing loss (CHL) with normal tympanic membranes (TM).
  26. pmc A case of nodular sclerosis Hodgkin's lymphoma repeatedly relapsing in the context of composite plasma cell-hyaline vascular Castleman's disease: successful response to rituximab and radiotherapy
    Lorenzo Falchi
    Section of Internal Medicine and Oncologic Sciences, Policlinico Monteluce, Perugia, Italy
    Eur J Haematol 79:455-61. 2007
    ..immunodeficiency virus-serum negative patient suffering from repeatedly relapsing classical Hodgkin's Lymphoma (cHL) associated with a histological picture of plasma cell-hyaline vascular (PC-HV) form of Castleman's disease (CD)...
  27. doi Spatial and temporal patterns of periphyton chlorophyll a related to pulp and paper mill discharges in four US receiving streams
    Camille A Flinders
    National Council for Air and Stream Improvement, Anacortes, Washington 982217, USA
    Integr Environ Assess Manag 5:259-69. 2009
    Nutrients in pulp and paper mill effluent (PPME) have been implicated in increased periphyton chlorophyll a (chl a) downstream of discharges...
  28. ncbi Mg-chelatase of tobacco: identification of a Chl D cDNA sequence encoding a third subunit, analysis of the interaction of the three subunits with the yeast two-hybrid system, and reconstitution of the enzyme activity by co-expression of recombinant CHL D,
    J Papenbrock
    Institut fur Pflanzengenetik und Kulturpflanzenforschung, Abt für Molekulare Zellbiologie, Gatersleben, Germany
    Plant J 12:981-90. 1997
    ..The CHL D polypeptide deduced from the open reading frame encodes a protein of 758 aa (82...
  29. ncbi Chlorophyllin protects cells from the cytostatic and cytotoxic effects of quinacrine mustard but not of nitrogen mustard
    B Ardelt
    Brander Cancer Research Institute at New York Medical College, 19 Bradhurst Avenue, Suite 2400, Hawthorne, NY 10532, USA
    Int J Oncol 18:849-53. 2001
    Chlorophyllin (CHL), the sodium and copper salt of chlorophyll, is capable of inhibiting the mutagenic activity of many chemical compounds...
  30. ncbi The rapid yellowing of spruce at a mountain site in the Central Black Forest (Germany). Combined effects of Mg deficiency and ozone on biochemical, physiological and structural properties of the chloroplasts
    Dorothea Siefermann-Harms
    Universitat Karlsruhe TH, Botanisches Institut I, Kaiserstr 12, D 76128 Karlsruhe, Germany
    J Plant Physiol 161:423-37. 2004
    ..s.l.). While at an early stage of yellowing the chlorophyll (Chl) content of the needles decreased slowly, significant changes occurred in the chloroplasts: The lability of the ..
  31. pmc Conductive hearing loss results in changes in cytochrome oxidase activity in gerbil central auditory system
    Debara Tucci
    Division of Otolaryngology Head and Neck Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Assoc Res Otolaryngol 3:89-106. 2002
    Conductive hearing loss (CHL) restricts auditory input to an intact peripheral auditory system...
  32. ncbi Outcomes and patient-based hearing status in conductive hearing loss
    M G Stewart
    Bobby R Alford Department of Otorhinolaryngology and Communication Sciences, Baylor College of Medicine, Houston, Texas 77030, USA
    Laryngoscope 111:1-21. 2001
    To study hearing status and quality of life outcomes in patients with conductive hearing loss (CHL), and to develop a prognostic disease severity staging system for use in future clinical outcomes studies in CHL.
  33. ncbi Selective indices on non-specific cell-mediated immunity in rabbits immunized with Chlamydophila psittaci
    Małgorzata Pawlikowska
    Department of Microbiology and Immunology, Faculty of Natural Sciences, University of Szczecin, Felczaka 3c, 71 412 Szczecin, Poland
    Arch Immunol Ther Exp (Warsz) 53:534-9. 2005
    Studies of non-specific immunity in infection or immunization with Chlamydophila (Chl.) Psittaci in static experimental models showed changes in parameters of this immunity...
  34. ncbi Differences in pigment composition, photosynthetic rates and chlorophyll fluorescence images of sun and shade leaves of four tree species
    Hartmut K Lichtenthaler
    Botanical Institute Molecular Biology and Biochemistry of Plants, University of Karlsruhe, Kaiserstrasse 12, D 76133 Karlsruhe, Germany
    Plant Physiol Biochem 45:577-88. 2007
    ..was comparatively determined by studying the photosynthetic rates via CO(2) measurements and also by imaging the Chl fluorescence decrease ratio (R(Fd)), which is an in vivo indicator of the net CO(2) assimilation rates...
  35. pmc A novel role of water-soluble chlorophyll proteins in the transitory storage of chorophyllide
    Christiane Reinbothe
    Lehrstuhl fur Pflanzenphysiologie, Universitat Bayreuth, D 95447 Bayreuth, Germany
    Plant Physiol 134:1355-65. 2004
    All chlorophyll (Chl)-binding proteins involved in photosynthesis of higher plants are hydrophobic membrane proteins integrated into the thylakoids...
  36. ncbi Effect of probucol on serum lipoprotein and apoprotein profiles in renal transplant patients
    M Okubo
    Department of Medicine, Sano Kohsei Hospital, Tochigi, Japan
    Am J Kidney Dis 31:356-9. 1998
    ..Twelve posttransplantation patients aged 34.2+/-2.5 years with serum total cholesterol (t-CHL) of 250 mg/dL or greater, whose serum creatinine was 2...
  37. ncbi Action of atorvastatin in combined hyperlipidemia : preferential reduction of cholesteryl ester transfer from HDL to VLDL1 particles
    M Guerin
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 321, Lipoproteines et Atherogenese, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 20:189-97. 2000
    Combined hyperlipidemia (CHL) is characterized by a concomitant elevation of plasma levels of triglyceride-rich, very low density lipoproteins (VLDLs) and cholesterol-rich, low density lipoproteins (LDLs)...
  38. doi Assessment of chlorophyll-a as a criterion for establishing nutrient standards in the streams and rivers of Illinois
    Todd V Royer
    School of Public and Environmental Affairs, Indiana Univ, Bloomington, IN 47405, USA
    J Environ Qual 37:437-47. 2008
    ..Algal biomass, measured as chlorophyll-a (chl-a), is a commonly proposed criterion, yet nutrient-chl-a relationships have not been well documented in Illinois at ..
  39. pmc Prochlorococcus, a marine photosynthetic prokaryote of global significance
    F Partensky
    Station Biologique, CNRS, INSU et Université Pierre et Marie Curie, F 29680 Roscoff
    Microbiol Mol Biol Rev 63:106-27. 1999
    ..It also possesses a remarkable pigment complement which includes divinyl derivatives of chlorophyll a (Chl a) and Chl b, the so-called Chl a2 and Chl b2, and, in some strains, small amounts of a new type of phycoerythrin...
  40. ncbi Mutation of the putative hydrogen-bond donor to P700 of photosystem I
    Yajing Li
    Department Chemistry, University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    Biochemistry 43:12634-47. 2004
    The primary electron donor of photosystem I (PS1), called P(700), is a heterodimer of chlorophyll (Chl) a and a'...
  41. ncbi [Photosynthesis and oxidative stress of leaves at different positions in Amomum villosum Lour]
    Zhi Li
    Kunming Division, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Kunming 650223, China
    Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao 30:546-52. 2004
    ..In this study we measured the variables of photosynthesis and chlorophyll fluorescence, the content of chlorophyll (Chl), Caroteniod, protein and malondialdehyde (MDA), and the activities of antioxidant enzymes of leaves at different ..
  42. ncbi [CHL prevent colon neoplasms in mice and its selective inhibition on COX-2]
    Xiao wen Ding
    Department of Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, P R China
    Ai Zheng 23:1409-13. 2004
    Chlorophyllin (CHL) was proved to have strong anti-inducement effect toward many mutagens and epicarcinogens...
  43. ncbi Estimation of chlorophyll content and daily primary production of the major algal groups by means of multiwavelength-excitation PAM chlorophyll fluorometry: performance and methodological limits
    Torsten Jakob
    Biology I Plant Physiology, University of Leipzig, Germany
    Photosynth Res 83:343-61. 2005
    ..The Phyto-PAM is a 4-wavelength chlorophyll fluorometer with the functional combination of chlorophyll (Chl) estimation and assessment of photosynthetic activity, both differentiated into the main algal groups...
  44. ncbi Fascin expression in diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and classical Hodgkin lymphoma
    Nasir A Bakshi
    Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, USA
    Arch Pathol Lab Med 131:742-7. 2007
    ..Reed-Sternberg cells and has a high negative predictive value for diagnosis of classical Hodgkin lymphoma (CHL). Fascin has been used to distinguish CHL from non-Hodgkin lymphoma...
  45. doi Origins of plastids and glyceraldehyde-3-phosphate dehydrogenase genes in the green-colored dinoflagellate Lepidodinium chlorophorum
    Kiyotaka Takishita
    Japan Agency for Marine Earth Science and Technology JAMSTEC, Yokosuka, Kanagawa, Japan
    Gene 410:26-36. 2008
    The dinoflagellate Lepidodinium chlorophorum possesses "green" plastids containing chlorophylls a and b (Chl a+b), unlike most dinoflagellate plastids with Chl a+c plus a carotenoid peridinin (peridinin-containing plastids)...
  46. ncbi [Trophic states and nutrient output of tributaries bay in Three Gorges Reservoir after impoundment]
    Sheng Zhang
    Chongqing Academe of Environmental Science, Chongqing 400020, China
    Huan Jing Ke Xue 29:7-12. 2008
    ..the Three Gorges Reservoir storaged water in June 2003, total phosphorus (TP), total nitrogen (TN), chlorophyll a (Chl-a), potassium permanganate index and Secchi depth (SD) were determined in 12 tributaries bay in Three Gorges ..
  47. doi Identification of excited-state energy transfer and relaxation pathways in the peridinin-chlorophyll complex: an ultrafast mid-infrared study
    Cosimo Bonetti
    Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands
    Phys Chem Chem Phys 12:9256-66. 2010
    ..is a water-soluble, trimeric light harvesting complex found in marine dinoflagellates that binds peridinin and Chl-a in an unusual stoichiometric ratio of 4:1...
  48. pmc The effects of experimentally induced conductive hearing loss on spectral and temporal aspects of sound transmission through the ear
    J Eric Lupo
    Department of Otolaryngology, University of Colorado Denver, Aurora, CO, USA
    Hear Res 272:30-41. 2011
    Conductive hearing loss (CHL) is known to produce hearing deficits, including deficits in sound localization ability...
  49. doi Properties of chlorophyll and derivatives in homogeneous and microheterogeneous systems
    Adriana P Gerola
    Chemistry Department, State University of Maringá, Paraná, Brazil
    J Phys Chem B 115:7364-73. 2011
    Chlorophyll (Mg-Chl) and its derivatives, zinc chlorophyll (Zn-Chl), copper chlorophyll (Cu-Chl), pheophytin (Pheo), pheophorbide (Pheid), and zinc chlorophyllide (Zn-Chld), were studied as to their acid-base equilibrium properties, ..
  50. ncbi The effect of decreasing temperature up to chilling values on the in vivo F685/F735 chlorophyll fluorescence ratio in Phaseolus vulgaris and Pisum sativum: the role of the photosystem I contribution to the 735 nm fluorescence band
    G Agati
    Istituto di Elettronica Quantistica CNR, Sezione INFM di Firenze, Florence, Italy
    Photochem Photobiol 72:75-84. 2000
    The effect of leaf temperature (T), between 23 and 4 degrees C, on the chlorophyll (Chl) fluorescence spectral shape was investigated under moderate (200 microE m-2 s-1) and low (30-35 microE m-2 s-1) light intensities in Phaseolus ..
  51. pmc The influence of nutrients and physical habitat in regulating algal biomass in agricultural streams
    Mark Munn
    Water Resource Division, US Geological Survey, 934 Broadway, Suite 300, Tacoma, WA 98402, USA
    Environ Manage 45:603-15. 2010
    ..Chlorophyll a was measured in three types of samples, fine-grained benthic material (CHL(FG)), coarse-grained stable substrate as in rock or wood (CHL(CG)), and water column (CHL(S))...
  52. pmc A comparative study of tissue distribution and photodynamic therapy selectivity of chlorin e6, Photofrin II and ALA-induced protoporphyrin IX in a colon carcinoma model
    A Orenstein
    Department of Plastic Surgery, Sheba Medical Centre, Tel Hashomer, Israel
    Br J Cancer 73:937-44. 1996
    ..of tissue distribution kinetics and photodynamic therapy (PDT) using 5-aminolaevulinic acid (ALA), chlorin e6 (Chl) and Photofrin (PII) was performed to evaluate the selectivity of porphyrin accumulation and tissue damage effects ..
  53. ncbi Zooplankton structure and potential food web interactions in the plankton of a subtropical chain-of-lakes
    Karl E Havens
    Watershed Management Department, South Florida Water Management District, West Palm Beach, FL 33496, USA
    ScientificWorldJournal 2:926-42. 2002
    ..species biomass and standard limnological attributes (temperature, pH, total phosphorus [TP], chlorophyll a [Chl a], and Secchi transparency) were quantified on a bimonthly basis from April 1997 to February 1999...
  54. pmc Synthesis of chlorophyll b: localization of chlorophyllide a oxygenase and discovery of a stable radical in the catalytic subunit
    Laura L Eggink
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    BMC Plant Biol 4:5. 2004
    ..light-harvesting complexes (LHCs) in the chloroplast of green algae and plants requires synthesis of chlorophyll (Chl) b, a reaction that involves oxygenation of the 7-methyl group of Chl a to a formyl group...
  55. ncbi Proliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin's and Reed-Sternberg cells
    Maria Bai
    Department of Pathology, Medical Faculty, University of Ioannina, 45110 Ioannina, Greece
    Mod Pathol 17:1338-45. 2004
    There is accumulating evidence that Hodgkin's and Reed-Sternberg cells of classical Hodgkin's lymphomas (cHL) display multiple and concurrent alterations in different pathways and checkpoints of the cell cycle...
  56. ncbi The stoichiometry and antenna size of the two photosystems in marine green algae, Bryopsis maxima and Ulva pertusa, in relation to the light environment of their natural habitat
    Jun Ya Yamazaki
    Department of Biology, Faculty of Science, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    J Exp Bot 56:1517-23. 2005
    ..Bryopsis maxima and Ulva pertusa had chlorophyll (Chl) a/b ratios of 1.5 and 1...
  57. ncbi Comparison of cladribine plus prednisone with chlorambucil plus prednisone in patients with chronic lymphocytic leukemia. Final report of the Polish Adult Leukemia Group (PALG CLL1)
    Tadeusz Robak
    Department of Hematology, Medical University of Łódź, Copernicus Memorial Hospital, Łódź, Poland
    Med Sci Monit 11:PI71-9. 2005
    ..multicenter trial on the efficacy and toxicity of cladribine (2-CdA) + prednisone (P) compared with chlorambucil (Chl) + P in previously untreated patients with progressive or symptomatic chronic lymphocytic leukemia...
  58. ncbi Fluorescence induction in the phycobilisome-containing cyanobacterium Synechococcus sp PCC 7942: analysis of the slow fluorescence transient
    Kostas Stamatakis
    Institute of Biology, NCSR Demokritos, Aghia Paraskevi, Attikis 15310, Greece
    Biochim Biophys Acta 1767:766-72. 2007
    At room temperature, the chlorophyll (Chl) a fluorescence induction (FI) kinetics of plants, algae and cyanobacteria go through two maxima, P at approximately 0...
  59. doi A survey of satisfaction and use among patients fitted with a BAHA
    Stephane Tringali
    Service d Oto neurochirurgie, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 69495, Pierre Benite Cedex, France
    Eur Arch Otorhinolaryngol 265:1461-4. 2008
    ..prosthesis BAHA (bone anchored hearing aid) according to the indications: conductive or mixed hearing loss (CHL) and patients with single side deafness (SSD)...
  60. pmc Antimicrobial susceptibility and mechanisms of resistance in Shigella and Salmonella isolates from children under five years of age with diarrhea in rural Mozambique
    Inacio Mandomando
    Centro de Investigação em Saúde da Manhiça, Vila da Manhiça, Rua 12, P O Box 1929, Maputo, Mozambique
    Antimicrob Agents Chemother 53:2450-4. 2009
    ..A high proportion of Shigella isolates were resistant to chloramphenicol (Chl) (52%), ampicillin (Amp) (56%), tetracycline (Tet) (66%), and trimethoprim-sulfamethoxazole (Sxt) (84%)...
  61. doi Site-directed mutations at D1-Thr179 of photosystem II in Synechocystis sp. PCC 6803 modify the spectroscopic properties of the accessory chlorophyll in the D1-branch of the reaction center
    Eberhard Schlodder
    Max Volmer Laboratorium für Biophysikalische Chemie, Technische Universitat Berlin, Germany
    Biochemistry 47:3143-54. 2008
    D1-Thr179, which overlies the reaction center chlorophyll Chl D1 of Photosystem II was replaced with His and Glu through site-directed mutation in Synechocystis sp. PCC 6803...
  62. ncbi Aluminum-induced effects on Photosystem II photochemistry in citrus leaves assessed by the chlorophyll a fluorescence transient
    Huan Xin Jiang
    Institute of Horticultural Plant Physiology, Biochemistry and Molecular Biology, Fujian Agriculture and Forestry University, Fuzhou 350002, P R China
    Tree Physiol 28:1863-71. 2008
    ..6H(2)O. Shoot growth was more sensitive to Al toxicity than root growth, gas exchange, chlorophyll (Chl) concentration, polyphasic Chl a fluorescence (OJIP) induction and related parameters...
  63. doi In vivo quantification of kleptoplastic chlorophyll a content in the "solar-powered" sea slug Elysia viridis using optical methods: spectral reflectance analysis and PAM fluorometry
    João Serôdio
    Departamento de Biologia and CESAM Centro de Estudos do Ambiente e do Mar, Universidade de Aveiro, Campus de Santiago, 3810 193, Aveiro, Portugal
    Photochem Photobiol Sci 9:68-77. 2010
    ..This study evaluated the use of two optical methods, spectral reflectance analysis and in vivo Chl fluorescence, as measured by pulse amplitude modulated (PAM) fluorometry, for the in vivo quantification of ..
  64. ncbi Removal of magnesium by Mg-dechelatase is a major step in the chlorophyll-degrading pathway in Ginkgo biloba in the process of autumnal tints
    L Tang
    Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Japan
    Z Naturforsch C 55:923-6. 2000
    Autumnal tints are one of the most manifest and fascinating natural phenomena, but the mechanism of chlorophyll (Chl)-breakdown in deciduous trees has not been fully elucidated...
  65. ncbi Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids
    L B Russell
    Biology Division, Oak Ridge National Laboratory, TN 37831 8077
    Mutat Res 282:151-8. 1992
    Melphalan (MLP), a bifunctional alkylating agent structurally related to the highly mutagenic chemical chlorambucil (CHL), was found to induce high frequencies of specific-locus mutations in postspermatogonial germ cells of the mouse, ..
  66. ncbi Light-dependent reversal of dark-chilling induced changes in chloroplast structure and arrangement of chlorophyll-protein complexes in bean thylakoid membranes
    Maciej Garstka
    Department of Metabolic Regulation, Institute of Biochemistry, Warsaw University, Miecznikowa 1, PL 02 096 Warsaw, Poland
    Biochim Biophys Acta 1710:13-23. 2005
    ..Although, no change in chlorophyll (Chl) content and Chl a/b ratio in all samples was observed, overall fluorescence intensity of fluorescence emission and ..
  67. ncbi A clinically silent respiratory infection with Chlamydophila spp. in calves is associated with airway obstruction and pulmonary inflammation
    Julia Jaeger
    Institute of Molecular Pathogenesis in the Friedrich Loeffler Institute Federal Research Institute for Animal Health, Naumburger Str 96a, 07743 Jena, Germany
    Vet Res 38:711-28. 2007
    ..Thirteen calves persistently infected with Chlamydophila (C.) abortus and/or C. pecorum (Chl+) were compared to 12 calves without chlamydial infections (Chl-)...
  68. ncbi [Trial for transdermal administration of sulfonylureas]
    Y Takahashi
    Department of Pharmacy, Yokohama City University Hospital, Kanagawa, Japan
    Yakugaku Zasshi 117:1022-7. 1997
    ..Glibenclamide (GLI) or chlorpropamide (CHL) was chosen as a principal agent and ointments were prepared by mixing 5% of GLI or CHL with a FAPG ointment base...
  69. pmc Characterization of chloramphenicol resistance in beta-hemolytic Escherichia coli associated with diarrhea in neonatal swine
    Kenneth M Bischoff
    Southern Plains Agricultural Research Center, Agricultural Research Service, U S Department of Agriculture, College Station, Texas 77845, USA
    J Clin Microbiol 40:389-94. 2002
    ..Interestingly, 53% of swine E. coli isolates exhibited resistance to chloramphenicol (CHL), an antibiotic whose use in food animals has been prohibited in the United States since the mid-1980s...
  70. ncbi Isolation and characterization of a xanthophyll-rich fraction from the thylakoid membrane of Dunaliella salina(green algae)
    Kittisak Yokthongwattana
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720 3102, USA
    Photochem Photobiol Sci 4:1028-34. 2005
    ..In the wild type, the zeaxanthin to chlorophyll (Zea/Chl)(mol : mol) ratio was as low as 0.009 : 1 under LL and as high as 0.8 : 1 under HL conditions...
  71. ncbi Characterization of a plant-like protochlorophyllide a divinyl reductase in green sulfur bacteria
    Aline Gomez Maqueo Chew
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 282:2967-75. 2007
    The green sulfur bacterium Chlorobium tepidum synthesizes three types of (bacterio)chlorophyll ((B)Chl): BChl a(P), Chl a(PD), and BChl c(F)...
  72. pmc Analysis of LhcSR3, a protein essential for feedback de-excitation in the green alga Chlamydomonas reinhardtii
    Giulia Bonente
    Dipartimento di Biotecnologie, Universita di Verona, Verona, Italy
    PLoS Biol 9:e1000577. 2011
    ..This mechanism prevents photodamage caused by reactive oxygen species produced by the reaction of chlorophyll (Chl) triplet states with O₂...
  73. doi Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs
    John J McGuire
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Biochem Pharmacol 77:1161-72. 2009
    ..g., methotrexate (MTX)) metabolism. Five new CH-1504 analogs (CHL-001-CHL-005) were synthesized and diastereomers of CH-1504 itself were obtained by preparative chiral HPLC; all ..
  74. ncbi Effects of ozone on chlorophyll and quantum yield of tobacco (Nicotiana tabacum L.) varieties
    C J Saitanis
    Laboratory of Ecology and Environmental Science, Agricultural University of Athens, Greece
    Chemosphere 42:945-53. 2001
    ..of leaf senescence, depression of photosynthetic mechanism, chlorophyll diminution and greater destruction of chl a than of chl b...
  75. ncbi Spectral characterization of chlorophyll fluorescence in barley leaves during linear heating. Analysis of high-temperature fluorescence rise around 60 degrees C
    P Ilík
    Department of Experimental Physics, Faculty of Science, Palacky University, Olomouc, Czech Republic
    J Photochem Photobiol B 59:103-14. 2000
    ..Leaves with various content of light harvesting complexes (green, Chl b-less chlorina f2 and intermittent light grown) revealing different types of FTC were used...
  76. ncbi Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells
    Florian Emmerich
    Humboldt University of Berlin, Universitatsklinikum Charite, Robert Rossle Klinik, Lindenberger Weg 80, 13125 Berlin, Germany
    J Pathol 201:413-20. 2003
    ..kappa B alpha (IkappaBalpha) have recently been identified in classical (c) HL-derived cell lines in a patient with cHL. In the present study, the NF-kappaB inhibitor I kappa B epsilon (IkappaBepsilon) has been analysed for somatic ..
  77. ncbi Repeated clonal relapses in classical Hodgkin's lymphoma and the occurrence of a clonally unrelated diffuse large B cell non-Hodgkin lymphoma in the same patient
    Roman K Thomas
    Molecular Tumor Biology and Tumor Immunology, Department I for Internal Medicine, University of Cologne, 50924 Cologne, Germany
    Leuk Lymphoma 45:1065-9. 2004
    Classical Hodgkin's lymphoma (cHL) and B-cell Non-Hodgkin Lymphoma (B-NHL) occasionally occur in the same patient. However, molecular studies that aim at determining the clonal relationship between both lymphomas are rare...
  78. ncbi Heat stress induces an inhibition of excitation energy transfer from phycobilisomes to photosystem II but not to photosystem I in a cyanobacterium Spirulina platensis
    Xiaogang Wen
    Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Photosynthesis Research Center, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant Physiol Biochem 43:389-95. 2005
    ..II (PSII) in a cyanobacterium Spirulina platensis grown at 30 degrees C were studied by measuring 77 K chlorophyll (Chl) fluorescence emission spectra...
  79. ncbi Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells
    Cheol Heui Yun
    International Vaccine Institute, Seoul, 151 818, Republic of Korea
    Int Immunopharmacol 6:252-9. 2006
    Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages...
  80. ncbi Assessment of anthocyanins in grape (Vitis vinifera L.) berries using a noninvasive chlorophyll fluorescence method
    Giovanni Agati
    Istituto di Fisica Applicata Nello Carrara, CNR, Via Madonna del Piano 10 Edificio C, I 50019 Sesto Fiorentino, Italy
    J Agric Food Chem 55:1053-61. 2007
    ..With increasing Anth content, less excitation light was transmitted to the deeper Chl layers, and thus the ChlF signal decreased proportionally...
  81. ncbi Use of industrial wastewater from olive-oil extraction for biomass production of Scenedesmus obliquus
    Gassan Hodaifa
    Complutense University of Madrid, Faculty of Chemical Science, Chemical Engineering, Ciudad Universitaria, S N, 28040 Madrid, Spain
    Bioresour Technol 99:1111-7. 2008
    ..The content in normalized chlorophyll diminished with the duration of the cultures, reaching a minimum CHL'(min) value, which showed an inhibition type similar to that of the specific growth rate...
  82. pmc The C-terminal extension of ferrochelatase is critical for enzyme activity and for functioning of the tetrapyrrole pathway in Synechocystis strain PCC 6803
    Roman Sobotka
    Institute of Microbiology, Department of Autotrophic Microorganisms, Opatovicky mlyn, 379 81 Trebon, Czech Republic
    J Bacteriol 190:2086-95. 2008
    Heme and chlorophyll (Chl) share a common biosynthetic pathway up to the branch point where magnesium chelatase and ferrochelatase (FeCH) insert either magnesium for Chl biosynthesis or ferrous iron for heme biosynthesis...
  83. doi Winter photosynthetic activity of twenty temperate semi-desert sand grassland species
    Zoltan Tuba
    Faculty of Agriculture and Environmental Sciences, Institute of Botany and Ecophysiology, Szent Istvan University, Godollo, Godollo, Hungary
    J Plant Physiol 165:1438-54. 2008
    The winter photosynthetic activity (quantified by net CO(2) assimilation rates and chlorophyll (Chl) a fluorescence parameters) of 20 plant species (including two lichens and two mosses) of a Hungarian temperate semi-desert sand ..
  84. pmc D1-arginine257 mutants (R257E, K, and Q) of Chlamydomonas reinhardtii have a lowered QB redox potential: analysis of thermoluminescence and fluorescence measurements
    Stuart Rose
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Photosynth Res 98:449-68. 2008
    ..site by studying differences from wild type on the steady-state turnover of PS II, as assayed through chlorophyll (Chl) a fluorescence yield decay after flash excitation...
  85. ncbi Evaluation of trophic state of Lake Uluabat, Turkey
    Ayse Elmaci
    Department of Environmental Engineering, Faculty of Engineering and Architecture, Uludag University, Gorukle Campus, 16059, Bursa, Turkey
    J Environ Biol 30:757-60. 2009
    ..Total nitrogen (TN), total phosphorus (TP), Secchi disc depth (SD) and chlorophyll a (Chl a) were analyzed monthly in order to assess the trophic state of the lake...
  86. doi Femtosecond primary charge separation in Synechocystis sp. PCC 6803 photosystem I
    Ivan V Shelaev
    N N Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia
    Biochim Biophys Acta 1797:1410-20. 2010
    ..During the first approximately 60 fs the energy transfer from the chlorophyll (Chl) species bleaching at 690 nm to the Chl bleaching at 705 nm occurs, resulting in almost equal bleaching of the two ..
  87. doi Reduced calcification decreases photoprotective capability in the coccolithophorid Emiliania huxleyi
    Kai Xu
    State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, PR China
    Plant Cell Physiol 53:1267-74. 2012
    ..The HCa-grown cells had higher photosynthetic and calcification rates and higher contents of Chl a and carotenoids compared with the naked (bearing no coccoliths) LCa-grown cells...
  88. ncbi Photosystem II antennae are not energetically connected: evidence based on flash-induced O2 evolution and chlorophyll fluorescence in sunflower leaves
    Vello Oja
    Institute of Molecular and Cell Biology, University of Tartu, Riia st 23, 51010 Tartu, Estonia
    Photosynth Res 114:15-28. 2012
    ..In parallel, Chl fluorescence yields F(0) (minimum), F(s) (steady-state), and F(m) (pulse-saturated), as well as fluorescence ..
  89. doi Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
    Enrico Tiacci
    Institute of Cell Biology Cancer Research, University of Duisburg Essen Medical School, Essen, Germany
    Blood 120:4609-20. 2012
    The pathogenesis of classical Hodgkin lymphoma (cHL), the most common lymphoma in the young, is still enigmatic, largely because its Hodgkin and Reed-Sternberg (HRS) tumor cells are rare in the involved lymph node and therefore difficult ..
  90. pmc Hyperdiversity of genes encoding integral light-harvesting proteins in the dinoflagellate Symbiodinium sp
    Lynda Boldt
    School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Queensland, Australia
    PLoS ONE 7:e47456. 2012
    ..LHC proteins bind chlorophyll (Chl) and carotenoids and include a family of LHCs that bind Chl a and c...
  91. doi Physiological and biochemical responses of Microcystis aeruginosa to glyphosate and its Roundup® formulation
    Huimin Qiu
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China
    J Hazard Mater 248:172-6. 2013
    ..The result suggested that both the cell numbers and Chl-a content of M. aeruginosa increased when the glyphosate concentration increased from 0.01 to 5mg P L(-1)...
  92. doi Wavelength-dependent photodamage to Chlorella investigated with a new type of multi-color PAM chlorophyll fluorometer
    Ulrich Schreiber
    Julius von Sachs Institut fur Biowissenschaften, Universitat Wurzburg, Julius von Sachs Platz 2, 97082 Wurzburg, Germany
    Photosynth Res 114:165-77. 2013
    ..for measurements of photodamage to photosystem II (PS II) in optically thin suspensions of Chlorella (200 μg Chl l(-1)) in the presence of 1 mM lincomycin...
  93. pmc Ten years after the prestige oil spill: seabird trophic ecology as indicator of long-term effects on the coastal marine ecosystem
    Roćio Moreno
    Department Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e77360. 2013
    ..the influence of North Atlantic Oscillation (NAO) index, the sea surface temperature (SST) and the chlorophyll a (Chl a) on the observed changes...
  94. doi Unequal allocation of excitation energy between photosystem II and I reduces cyanolichen photosynthesis in blue light
    Knut Asbjørn Solhaug
    Norwegian University of Life Sciences, Department of Ecology and Natural Resource Management, PO Box 5003, NO 1432 As, Norway
    Plant Cell Physiol 55:1404-14. 2014
    ..with PSII have a low blue light absorption, our results are consistent with blue light absorption mainly by Chl in PSI...
  95. doi Changes in the use of radiation therapy for early classical Hodgkin lymphoma in adolescents and young adults: implications for survival and second malignancies
    Ana C Xavier
    a Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA
    Leuk Lymphoma 56:2339-43. 2015
    Omission of radiation therapy (RT) in adolescents and young adults (AYA) with early classical Hodgkin lymphoma (cHL) may affect survival and risk of second malignancies (SMN)...
  96. doi The relationships of meteorological factors and nutrient levels with phytoplankton biomass in a shallow eutrophic lake dominated by cyanobacteria, Lake Dianchi from 1991 to 2013
    Qichao Zhou
    Yunnan Key Laboratory of Pollution Process and Management of Plateau Lake Watershed, Yunnan Institute of Environmental Science Kunming China International Research Center for Plateau Lake, Kunming, 650034, China
    Environ Sci Pollut Res Int 23:15616-26. 2016
    ..The interannual ln(chl. a) exhibited positive correlations with the mean air temperature, mean minimum air temperature, and mean maximum ..
  97. ncbi Association of DDX58 177 C > T polymorphism with decreased risk of Epstein-Barr virus-related nodular sclerosis classical Hodgkin lymphoma
    Paloma Martin
    a Group of Molecular Pathology, Instituto de Investigación Puerta de Hierro IDIPHIM, Majadahonda, Spain
    Leuk Lymphoma 58:438-444. 2017
    Classical Hodgkin lymphoma (cHL) is frequently related to Epstein-Barr virus (EBV) infection. Its malignant capacity is attributed to disruption of an EBV-host balance influenced by environmental and genetic drivers...
  98. doi The immunophenotypic spectrum of primary mediastinal large B-cell lymphoma reveals prognostic biomarkers associated with outcome
    Jacob R Bledsoe
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts
    Am J Hematol 91:E436-41. 2016
    ..is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) that shows overlap with classical Hodgkin lymphoma (CHL) and a favorable prognosis compared to mediastinal gray-zone lymphoma (MGZL)...
  99. doi Low-dose pembrolizumab for relapsed/refractory Hodgkin lymphoma: high efficacy with minimal toxicity
    Thomas S Y Chan
    Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
    Ann Hematol . 2017
    Five patients with refractory/relapsed classical Hodgkin lymphoma (cHL), four having failed multiple lines of chemotherapy and brentuximab vedotin, were treated with low-dose pembrolizumab (median dose 100 mg, range: 100-200 mg, every ..
  100. ncbi Chlorophyll b is involved in long-wavelength spectral properties of light-harvesting complexes LHC I and LHC II
    V H Schmid
    Institut fur Allgemeine Botanik, Johannes Gutenberg Universitat, Mainz, Germany
    FEBS Lett 499:27-31. 2001
    Chlorophyll (Chl) molecules attached to plant light-harvesting complexes (LHC) differ in their spectral behavior...
  101. ncbi Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2
    Stefan Joos
    Deutsches Krebsforschungszentrum, Abteilung Organisation komplexer Genome, Heidelberg, Germany
    Blood 99:1381-7. 2002
    Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients comprising 8 lymphocyte-rich (cHL-LR), 16 nodular sclerosis (cHL-NS), 15 mixed-cellularity (cHL-MC), and 2 lymphocyte-..

Research Grants40

  1. MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS
    George Bailey; Fiscal Year: 1999
    ..In the current grant period we used the trout model to show for the first time that chlorophyllin (CHL), a common food-grade chlorophyll derivative, has potent, dose-responsive blocking activity against aflatoxin B1 ..
  2. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2000
    Chlorophyllin (CHL), a clinically used water-soluble salt of chlorophyll, exhibits antimutagenic activity in vitro by a mechanism that involves complex formation with the carcinogen...
  3. CRYSTAL STUDIES OF LIGHT-HARVESTING CHL A/B COMPLEX
    Mary Lyon; Fiscal Year: 1992
    ..This information and further development of the methodologies used will help in understanding membrane proteins in general, a class of protein whose structural-functional relationships remain almost entirely unknown..
  4. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..of newborn hearing screen programs to identify sensorineural hearing loss (SNHL) and conductive hearing loss (CHL)...
  5. Hideko Heidi Nakajima; Fiscal Year: 2016
    Project Summary/Abstract Many patients suffer from conductive hearing loss (CHL) that is intractable to treatment, although their neurosensory system is intact...
  6. Glycoproteins and Glycan-Binding IgGs: Biomarkers for Cancer and Inflammatory Di
    Hyesook Kim; Fiscal Year: 2013
    ..glycans with immunoglobulin (Ig) fractions isolated from breast cancer and classical Hodgkin's lymphoma (cHL) patients. For both studies, subsequent direct ELISAs with larger sample sizes verified the glycan biomarkers...
  7. Daniel J Tollin; Fiscal Year: 2016
    ..the behavioral deficits in binaural hearing produced by early developmental exposure to conductive hearing loss (CHL)...
  8. DAN HARVEY SANES; Fiscal Year: 2015
    ..are three related aims: Aim 1 will first determine whether the effect of developmental conductive hearing loss (CHL) on auditory cortex inhibitory synapse function persists into adulthood...
  9. Daniel B Polley; Fiscal Year: 2016
    ..Degraded hearing in the form of conductive hearing loss (CHL) such as otitis media with effusion is the most commonly diagnosed illness among children in the United States and ..
  10. Margaret A Shipp; Fiscal Year: 2016
    ..For example, two lymphoid malignancies that primarily strike young healthy adults, classical Hodgkin lymphoma (cHL) and primary mediastinal large B-cell lymphoma (MLBCL), are largely defined by their morphologic appearance and ..
  11. ROLE OF THE GALLBLADDER IN PATHOGENESIS OF GALLSTONES
    LESTER WILLIAMS; Fiscal Year: 1991
    ..Obesity and older age also may be risks. Cholesterol (CHL) GS formation in experimental animals is associated with both bile lithogencity and abnormal biliary motility, but ..
  12. ANTIIDIOTYPE VACCINE THERAPY OF HUMAN COLORECTAL CANCER
    MALAYA CHATTERJEE; Fiscal Year: 2002
    ..setting generate an active immune response against CEA following an adequate number of immunizations with the Chl anti-Id adsorbed to aluminum hydroxide...
  13. Novel Biologic Therapies for Hodgkin's Lymphoma
    Yvette L Kasamon; Fiscal Year: 2012
    ..into the B-cell origin of the Reed-Sternberg (RS) cell point to new immunotherapeutic targets for classical HL (cHL)...
  14. COMMUNITY HEALTH LINK: ACCESS TO INFORMATION RESOURCES
    Thomas Lewis; Fiscal Year: 2004
    ..are currently served by a safety-net system of private, non-profit clinics, known as Community HealthLink (CHL). CHL serves 15,000 low-income, uninsured Montgomery County residents annually...
  15. STRUCTURE AND FUNCTION OF SV40 NON-VIRION PROTEINS
    David Livingston; Fiscal Year: 2007
    ..biological effects of lead small molecule compounds that can effectively interfere with the interaction of p300/CBP CHl and the TAD-C domain of hypoxia -inducing factor and thereby act as anti-tumor agents; 3) to determine whether the ..
  16. Hearing loss affects synaptic balance in auditory cortex
    Dan Sanes; Fiscal Year: 2009
    ..The core hypothesis of this proposal is that sensorineural (SNHL) or conductive hearing loss (CHL) disrupts the balance between excitatory and inhibitory conductances, and severely limits the ability of primary ..
  17. SPECIFIC INHIBITION OF HER2/NEU TRANSCRIPTION ELONGATION
    Scot Ebbinghaus; Fiscal Year: 2002
    ..to find novel ways to specifically inhibit HER2/neu expression by developing oligonucleotide (ODN) - chlorambucil (CHL) conjugates that will bind in a site-specific manner to the HER2/neu gene by triplex DNA formation and lead to DNA ..
  18. A Wide-band Reflectance - DPOAE (WR-DP)Screener
    PATRICIA JENG; Fiscal Year: 2004
    ..infants with sensorineural hearing loss (SNHL), but most neonates who fail screening have conductive hearing loss (CHL) rather than sensorineural hearing loss, resulting in high false positive rate and costly follow-up diagnostic ..
  19. Polyamide-Chl inhibition of cancer cell proliferation
    JOEL GOTTESFELD; Fiscal Year: 2009
    ..The mechanism of inhibition of transcription by polyamides will be assessed both in vitro, in cell culture and in animal models...
  20. GERMLINE MUTATIONS INDUCED IN THE MOUSE
    Lorraine Flaherty; Fiscal Year: 2002
    ..In the course of studying chlorambucil-induced mutagenesis in the mouse, we have found that chlorambucil (CHL) is a very efficient inducer of recessive visible mutations...
  21. Randomized, controlled trial of daily trimethoprim-sulfamethoxazole or weekly chl
    CHRISTOPHER PLOWE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. NUTRITION ACADEMIC AWARD
    Robert Knopp; Fiscal Year: 2002
    ..It is time to begin aggressive, substantive nutrition educational programs in cardiovascular disease prevention. ..
  23. Central Auditory system Effects of Auditory Deprivation
    Debara Tucci; Fiscal Year: 2006
    ..We hypothesize that the potential for reversibility will depend upon the type and severity of the structural modification induced by conductive impairment, and the developmental stage of the animal at the time of the insult. ..
  24. Building the researchers in audiology and hearing
    Debara Tucci; Fiscal Year: 2003
    ....
  25. DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME
    Robert Knopp; Fiscal Year: 2009
    ..This study will be the first to demonstrate dietary benefit for dyslipidemia, inflammation and vascular stress in MetS at stable weight. ..
  26. REGULATION OF BILIPROTEIN IN CYANOBACTERIA
    DONALD BRYANT; Fiscal Year: 2002
    ..These last studies could explain bloom disappearance in natural populations and could suggest new approaches for the control of problematic or toxic cyanobacteria in water supplies. ..
  27. CELLULAR THERMOSTABILITY AND THERMOTOLERANCE
    JAMES LEPOCK; Fiscal Year: 2001
    ....
  28. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..abstract_text> ..
  29. STRUCTURE AND FUNCTION OF CAROTENOIDS
    Harry Frank; Fiscal Year: 2008
    ..Several preliminary studies have already been carried out by us in support of the methods we propose to employ. ..
  30. Enhancement of methotrexate uptake in childhood ALL
    John McGuire; Fiscal Year: 2009
    ..If successful, this research could provide a way to increase the effectiveness of methotrexate, a key drug used in treating childhood acute lymphoblastic leukemia, and thus increase the cure rate in this disease. ..
  31. FOLYLPOLYGLUTAMATE SYNTHETASE IN CANCER CHEMOTHERAPY
    John McGuire; Fiscal Year: 2003
    ..This may explain why high-level resistance to pulse MTX can occur in the absence of a large decrease in total FPGS activity or a rise in glutamyl hydrolase activity. ..
  32. Structure and function of antimicrobial peptides
    Ayyalusamy Ramamoorthy; Fiscal Year: 2008
    ..These peptides have therapeutic potential as antibiotics and have particular importance for cystic fibrosis patients. ..
  33. ACOUSTIC RESPONSES OF THE HUMAN COCHLEA AND MIDDLE EAR
    DOUGLAS KEEFE; Fiscal Year: 2008
    ....
  34. Clinical Activity of 17-AAG in Lymphoma
    Anas Younes; Fiscal Year: 2007
    ..In Aim 3 we will correlate the biologic effects of 17-AAG and clinical response in patients with relapsed MCL, ALCL, and HL. [unreadable] [unreadable] [unreadable]..
  35. Characterization of Methods for Preservation of Phosphoproteins in fixed tissues
    Eric Hsi; Fiscal Year: 2007
    ..Furthermore, control material with defined relative expression levels of many PPs will result from this application and allow laboratories to assess performance of their individual assays. [unreadable] [unreadable] [unreadable]..
  36. Experimental R&D for Rapid Sequencing Nanotechnology
    James Lee; Fiscal Year: 2007
    ..This (R21/R33) R&D project proposal is in response to NIH RFA-HG-04-003 program announcement for Revolutionary Genome Sequencing Technologies. [unreadable] [unreadable]..
  37. Computational R&D for Rapid Sequencing Nanotechnology
    James Lee; Fiscal Year: 2007
    ..This (R21/R33) project proposal is in response to NIH RFA-HG-04-003 program announcement for Revolutionary Genome Sequencing Technologies. [unreadable] [unreadable]..
  38. Purchase of a 500 MHz Solid State NMR Spectrometer
    Ayyalusamy Ramamoorthy; Fiscal Year: 2007
    ..unreadable] [unreadable] All the major users of the instrument are supported by NIH R01 grants. [unreadable] [unreadable] [unreadable]..
  39. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  40. DEVELOPMENT OF A MIDDLE EAR BALLOON IMPLANT
    SAUMIL MERCHANT; Fiscal Year: 2003
    ..There is a large market potential for this implant, estimated at over 65,000 devices annually in the U.S. alone. ..