cholecystokinin

Summary

Gene Symbol: cholecystokinin
Description: cholecystokinin
Alias: cholecystokinin, cholecystokinin triacontatriapeptide, prepro-cholecystokinin
Species: human

Top Publications

  1. pmc CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders
    R T Jensen
    National Institutes of Health, Bethesda, Maryland 20892-1804, USA
    Yale J Biol Med 69:245-59. 1996
  2. ncbi 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 56:1245-8. 2009
  3. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
  4. ncbi Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study
    Filippo Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota
    Am J Gastroenterol 100:652-63. 2005
  5. ncbi Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women
    Kerstin Sturm
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
    J Clin Endocrinol Metab 88:3747-55. 2003
  6. pmc The biochemical characterization of the native pancreatic cholecystokinin receptor using affinity labeling approaches
    L J Miller
    Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905
    Yale J Biol Med 65:441-8; discussion 465-9. 1992
  7. pmc Receptor strategies in pancreatitis
    J H Grendell
    University of California, San Francisco
    Yale J Biol Med 65:431-6; discussion 437-40. 1992
  8. ncbi Humoral factors released during trauma of Aplysia body wall. II. Effects of possible mediators
    B F Cooper
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    J Comp Physiol B 159:225-35. 1989
  9. ncbi Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors
    A Escherich
    Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Biopolymers 56:55-76. 2000
  10. ncbi Gastrointestinal hormones and the quantitation of spontaneous duodenal motor activity
    M F Tansy
    Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140
    Toxicol Pathol 16:118-22. 1988

Research Grants

  1. CCK MODULATION OF ANXIETY AND THE HPA AXIS
    James Abelson; Fiscal Year: 1999
  2. CHOLECYSTOKININ IN PATHOGENESIS OF HUMAN PANCREATIC ADCA
    David Weinberg; Fiscal Year: 1999
  3. Gail L Matters; Fiscal Year: 2016
  4. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 2001
  5. Laurence J Miller; Fiscal Year: 2014
  6. Type A CCK Receptor Structure Function and Regulation
    Laurence J Miller; Fiscal Year: 2010
  7. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
  8. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
  9. CHOLECYSTOKININ EFFECT ON PANCREATIC GROWTH & TUMORS
    Thomas Adrian; Fiscal Year: 1992
  10. STRUCTURE AND FUNCTION OF CHOLECYSTOKININ RECEPTORS
    Steven Rosenzweig; Fiscal Year: 1991

Detail Information

Publications575 found, 100 shown here

  1. pmc CCKB/gastrin receptor antagonists: recent advances and potential uses in gastric secretory disorders
    R T Jensen
    National Institutes of Health, Bethesda, Maryland 20892-1804, USA
    Yale J Biol Med 69:245-59. 1996
    b>Cholecystokinin (CCK) and the structurally related peptide, gastrin, have numerous effects on tissues in the central nervous system and gastrointestinal tract. Recent studies show these effect are mediated by a CCKA and CCKB receptor...
  2. ncbi 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 56:1245-8. 2009
    The role of genetics in the susceptibility to functional dyspepsia (FD) is not well established. Cholecystokinin (CCK) is released from enteroendocrine cells in the duodenal mucosa after food ingestion and signals satiation through ..
  3. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
    Expression of the brain-gut peptide cholecystokinin (CCK) in the developing olfactory-gonadotropin-releasing hormone-1 (GnRH-1) neuroendocrine systems was characterized, and the function of CCK in these systems was analyzed both in vivo ..
  4. ncbi Effect of CCK-1 antagonist, dexloxiglumide, in female patients with irritable bowel syndrome: a pharmacodynamic and pharmacogenomic study
    Filippo Cremonini
    Clinical Enteric Neuroscience Translational and Epidemiological Research C E N T E R Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota
    Am J Gastroenterol 100:652-63. 2005
    b>Cholecystokinin (CCK) is involved in gastrointestinal motor response to meals. The potential role of CCK receptor antagonists in functional gastrointestinal disorders is unclear.
  5. ncbi Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women
    Kerstin Sturm
    Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia
    J Clin Endocrinol Metab 88:3747-55. 2003
    ..To investigate possible contributions of enhanced satiating effects of cholecystokinin (CCK) and reduced stimulation of food intake by ghrelin, eight undernourished older women [age, 80.4 +/- 2...
  6. pmc The biochemical characterization of the native pancreatic cholecystokinin receptor using affinity labeling approaches
    L J Miller
    Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota 55905
    Yale J Biol Med 65:441-8; discussion 465-9. 1992
    ..The rat pancreatic acinar cell receptor for cholecystokinin (CCK), the major physiologic hormonal stimulant of pancreatic exocrine secretion, has been the target of such ..
  7. pmc Receptor strategies in pancreatitis
    J H Grendell
    University of California, San Francisco
    Yale J Biol Med 65:431-6; discussion 437-40. 1992
    ..These receptors are potential sites of action for therapeutic agents in the treatment of pancreatitis. Cholecystokinin (CCK) receptor antagonists, which may reduce the level of metabolic "stress" on acinar cells, have been shown ..
  8. ncbi Humoral factors released during trauma of Aplysia body wall. II. Effects of possible mediators
    B F Cooper
    Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225
    J Comp Physiol B 159:225-35. 1989
    ..Adenosine, octopamine, arginine vasotocin, and cholecystokinin (CCK-8) caused weak or variable contractions...
  9. ncbi Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors
    A Escherich
    Max-Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Biopolymers 56:55-76. 2000
    The (neuro)hormones gastrin and cholecystokinin (CCK) share a common C-terminal tetrapeptide amide sequence that has been recognized as the message portion while the N-terminal extensions are responsible for the CCK(A) and CCK(B) ..
  10. ncbi Gastrointestinal hormones and the quantitation of spontaneous duodenal motor activity
    M F Tansy
    Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140
    Toxicol Pathol 16:118-22. 1988
    ..In addition to the classical GI hormones (secretin, gastrin, and cholecystokinin-pancreozymin (CCK-PZ], there are at least nine other peptides whose structures and GI effects are known...
  11. ncbi Bombesin and ceruletide-induced grooming and inhibition of ingestion in the rat
    P J Kulkosky
    Department of Psychology, University of Southern Colorado, Pueblo 81001
    Ann N Y Acad Sci 525:201-18. 1988
    ..b>Cholecystokinin-like peptide-induced grooming is observed after central injection in the rat and is unaccompanied by changes ..
  12. pmc Acid secretion and the H,K ATPase of stomach
    C Prinz
    University of California at Los Angeles
    Yale J Biol Med 65:577-96. 1992
    ..The isolated ECL cell of rat gastric mucosa responds to gastrin/cholecystokinin (CCK), acetylcholine, and epinephrine with histamine release and to somatostatin and R-alpha-methyl histamine ..
  13. ncbi Gastric gland degeneration induced in monkeys by the CCK-B/gastrin receptor antagonist CI-988
    L A Dethloff
    Department of Pathology and Experimental Toxicology, Parke Davis Pharmaceutical Research, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 25:441-8. 1997
    Gastric effects of subchronic treatment with the cholecystokinin-B (CCK-B)/gastrin receptor antagonist CI-988 were investigated in cynomolgus monkeys...
  14. pmc GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor
    J D Gale
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 111:332-8. 1994
    ..However, the compound had no effect on cholecystokinin (CCK-8)-induced contraction in concentrations up to 1 microM. 3...
  15. pmc Characterization of the receptors and mechanisms involved in the cardiovascular actions of sCCK-8 in the pithed rat
    A J Gaw
    Peptic Ulceration Group, Pharmacology I, Glaxo Research and Development Ltd, Ware, Herts
    Br J Pharmacol 115:660-4. 1995
    1. The cardiovascular actions of cholecystokinin and related peptides were investigated in the pithed rat. The receptors and the mechanisms involved in these experiments were characterized. 2...
  16. ncbi Cholecystokinin and vasoactive intestinal peptide in brain and gut of the hypothyroid neonatal rat
    B Zheng
    Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, New York
    Horm Metab Res 21:127-31. 1989
    ..We have determined the concentrations and contents of immunoreactive cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in the brain and gut of groups of rats exposed to antithyroid ..
  17. ncbi Comparison of the effects of simmondsin and cholecystokinin on metabolism, brown adipose tissue and the pancreas in food-restricted rats
    G Flo
    Interdisciplinary Research Centre, Katholieke Universiteit Leuven Campus Kortrijk, Belgium
    Horm Metab Res 30:504-8. 1998
    ..a satiety-inducing glycoside extracted from jojoba seeds, and the gastro-intestinal satiation peptide, cholecystokinin. The effects of intraperitoneal injection of the biological active CCK-octapeptide on the pancreas, ..
  18. pmc Reversal of CRF- and dopamine-induced stimulation of colonic motility by CCK and igmesine (JO 1784) in the rat
    M Gue
    Department of Pharmacology, INRA, Toulouse, France
    Br J Pharmacol 111:930-4. 1994
    ..stress (ES)-induced stimulation of colonic motility, as well as the mechanism of antagonistic action of cholecystokinin octapeptide (CCK-8s) and igmesine (alpha sigma receptor ligand, formerly JO 1784) on dopamine-induced colonic ..
  19. ncbi Modulation of immune function by intestinal neuropeptides
    L P Sirinek
    Department of Pediatrics, Ohio State University, Columbus
    Acta Oncol 30:509-17. 1991
    ..Peptides to be discussed include substance P, somatostatin, vasoactive intestinal peptide (VIP), the opioid peptides leu and met enkephalin, calcitonin gene related peptide (CGRP), neuropeptide Y, and cholecystokinin (CCK).
  20. ncbi Protecting effects of vasoactive intestinal polypeptide on lymphocytes against metal toxicity
    K Nordlind
    Department of Dermatology, Karolinska Hospital, Stockholm, Sweden
    Immunopharmacol Immunotoxicol 14:323-30. 1992
    The hormonal neuropeptides calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP), were investigated for a potential protective effect on thymocytes after a toxic dose ..
  21. ncbi Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies
    Martin Behe
    Department of Nuclear Medicine of the Philipps University of Marburg, Marburg, Germany
    Biopolymers 66:399-418. 2002
    ..Indeed, autoradiographic studies demonstrated cholecystokinin (CCK)-B/gastrin receptors not only in over 90% of MTCs, but in a high percentage of small cell lung cancers, ..
  22. pmc Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats
    Xiao Yun Zhao
    The First Affiliated Hospital of Shantou University Medical College, Shantou 515031, Guangdong Province, China
    World J Gastroenterol 11:3405-10. 2005
    To explore the effect of sulfated cholecystokinin octapeptide (sCCK-8) on cardiac functions and its receptor mechanism in endotoxic shock (ES) rats.
  23. ncbi Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8S to rat brain cortical membranes
    A Rinken
    Institute of Chemical Physics, University of Tartu, Estonia
    Biochem Pharmacol 55:423-31. 1998
    The binding of [3H]cholecystokinin octapeptide (sulphated) ([3H]CCK-8S), an agonist of the cholecystokinin receptors, to rat cortical membranes was fast, specific and saturable, with pH optimum at 6.5-7.0...
  24. ncbi Cholecystokinin-B/gastrin receptor binding peptides: preclinical development and evaluation of their diagnostic and therapeutic potential
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Clin Cancer Res 5:3124s-3138s. 1999
    ..Indeed, autoradiographic studies demonstrated cholecystokinin (CCK)-B/gastrin receptors not only in >90% of MTCs but in a high percentage of small cell lung cancers and ..
  25. ncbi The role of cholecystokinin (CCK), CCK-A or CCK-B receptor antagonists in the spontaneous preference for drugs of abuse (alcohol or cocaine) in naive rats
    F Crespi
    Dept of Pharmacology, Glaxo Wellcome S p A, Verona, Italy
    Methods Find Exp Clin Pharmacol 20:679-97. 1998
    ..Low, selective doses (5 micrograms/kg) of the specific cholecystokinin (CCK)-A receptor antagonist L-364,718 largely reduced the intake of ethanol 10% of ED rats only...
  26. ncbi The effect of cholecystokinin peptides on ovine duodeno-jejunal slow waves with and without pretreatment with proglumide
    K W Romanski
    Department of Animal Physiology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland
    J S Afr Vet Assoc 78:209-14. 2007
    b>Cholecystokinin exerts a composite influence on gastrointestinal motility but little is known about its effect on small-intestinal slow waves...
  27. ncbi Preferential blockade of cholecystokinin-8S-induced increases in aspartate and glutamate levels by the CCK(B) receptor antagonist, L-365,260, in rat brain
    J Ge
    Department of Pharmacology, School of Medical Sciences, University of Bristol, UK
    Eur J Pharmacol 345:163-70. 1998
    In the present studies, the ability of a locally delivered cholecystokinin (CCK) receptor agonist and systemically delivered antagonists to modulate extracellular levels of aspartate and glutamate in the frontal cortex of anaesthetised ..
  28. ncbi Cholecystokinin stimulates neuronal receptors to produce contraction of the canine colon
    F C Barone
    Department of Pharmacology, Smith Kline and French Laboratories, King of Prussia, PA 19406
    Life Sci 44:533-42. 1989
    The motor effects of cholecystokinin 26-33-amide (CCK octapeptide; CCK-OP) and several purported CCK receptor antagonists on canine colonic circular muscle were determined in pentobarbital anesthetized dogs...
  29. ncbi Identification of cholecystokinin-B/gastrin receptor domains that confer high gastrin affinity: utilization of a novel Xenopus laevis cholecystokinin receptor
    F Schmitz
    Division of Gastroenterology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Mol Pharmacol 50:436-41. 1996
    A hallmark of the mammalian brain cholecystokinin (CCK) receptor, CCK-B/gastrin (CCK-BR), is its high affinity for two structurally related peptides, CCK and gastrin...
  30. ncbi Activation of phospholipase C by cholecystokinin receptor subtypes with different G-protein-coupling specificities in hormone-secreting pancreatic cell lines
    R H Paulssen
    Institute of Clinical Medicine, University of Tromso, Norway
    Biochem Pharmacol 60:865-75. 2000
    ..pancreatic cell lines using the non-hydrolyzable GTP analogue GTPgammaS alone, the C-terminal octapeptide cholecystokinin (CCK-8), or gastrin. All compounds caused a significant 2- to 4...
  31. pmc Gallbladder motor function, plasma cholecystokinin and cholecystokinin receptor of gallbladder in cholesterol stone patients
    Jian Zhu
    Department of Surgery, Ruijin Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Surgery, Shanghai 200025, China
    World J Gastroenterol 11:1685-9. 2005
    To study the interactive relationship of gallbladder motor function, plasma cholecystokinin (CCK) and cholecystokinin A receptor (CCK-R) of gallbladder in patients with cholesterol stone disease.
  32. pmc Functional comparisons of gastrin/cholecystokinin receptors in isolated preparations of gastric mucosa and ileum
    M Patel
    Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd, Ware, Hertfordshire
    Br J Pharmacol 106:275-82. 1992
    1. The gastrin cholecystokinin (CCK) receptors mediating stimulation of acid secretion in rat isolated gastric mucosa (RGM) and contraction in guinea-pig isolated ileum longitudinal muscle-myenteric plexus (GPI) have been characterized ..
  33. pmc The pathways regulating acid secretion: the view from the isolated cell
    C N Chuang
    VA Wadsworth Hospital Center, Los Angeles, California 90073, USA
    Yale J Biol Med 67:107-12. 1994
    ..Furthermore, the mechanisms integrating these paracrine, exocrine and neural elements require elucidation...
  34. pmc Effects of cholecystokinin-58 on type 1 cholecystokinin receptor function and regulation
    S Vincent Wu
    Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics, 13400 East Shea Blvd, Scottsdale, AZ 85259, USA
    Am J Physiol Gastrointest Liver Physiol 295:G641-7. 2008
    b>Cholecystokinin, like many peptide hormones, is present as multiple molecular forms...
  35. pmc The regulation of histidine decarboxylase gene expression
    M Hocker
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
    Yale J Biol Med 69:21-33. 1996
    ..Taken together, these studies are consistent with the concept of HDC transcriptional regulation as at least one phase of the overall response to gastrin...
  36. ncbi Stimulation of either cholecystokinin receptor subtype reduces while antagonists potentiate or sensitize a morphine-induced excitatory response
    L F Felicio
    Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Brazil 05508 970
    Peptides 22:1299-304. 2001
    b>Cholecystokinin peptides (CCK) have been shown to antagonize many opioid-mediated effects...
  37. ncbi Overexpression of cholecystokinin receptors in azaserine-induced neoplasms of the rat pancreas
    R H Bell
    Department of Pathology, Dartmouth Medical School, Hanover, New Hampshire 03756
    Cancer Res 52:3295-9. 1992
    b>Cholecystokinin (CCK) is a growth factor for normal pancreas. Numerous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat...
  38. ncbi Cholecystokinin-8 and nerve growth factor: two endogenous molecules working for the upkeep and repair of the nervous system
    P Tirassa
    Institute of Neurobiology and Molecular Medicine CNR, Rome, Italy
    Curr Drug Targets CNS Neurol Disord 1:495-510. 2002
    b>Cholecystokinin-8 (CCK-8), the small peptide initially described as a gastric factor involved in the regulation of feeding behavior, is today recognized as one of the most abundant neurotransmitters/ neuropeptides in brain and is an ..
  39. ncbi First intracellular loop of the human cholecystokinin-A receptor is essential for cyclic AMP signaling in transfected HEK-293 cells
    V Wu
    CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, UCLA School of Medicine, and West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90073
    J Biol Chem 272:9037-42. 1997
    b>Cholecystokinin (CCK)-A and CCK-B receptors are highly homologous members of the seven transmembrane domain G-protein-coupled receptor superfamily. Genes of both receptors contain five exons and share a similar exon-intron organization...
  40. ncbi CCK receptor antagonists in animal models of anxiety: comparison between exploration tests, conflict procedures and a model based on defensive behaviours
    G Griebel
    , Bagneux, France
    Behav Pharmacol 8:549-60. 1997
    ....
  41. ncbi Full and partial agonist activity of C-terminal cholecystokinin peptides at the cloned human CCK-A receptor expressed in Chinese hamster ovary cells
    J Dunlop
    Wyeth Ayerst Research, Princeton, NJ 08540, USA
    Peptides 18:865-8. 1997
    The agonist activities of the C-terminal cholecystokinin peptides sulfated cholecystokinin octapeptide (CCK-8S), non-sulfated cholecystokinin octapeptide (CCK-8NS), pentagastrin and CCK-4 at the cloned human CCK-A receptor expressed in ..
  42. ncbi Enhanced gastric emptying of a liquid gastric load in mice lacking cholecystokinin-B receptor: a study of CCK-A,B, and AB receptor gene knockout mice
    Kyoko Miyasaka
    Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo, 173 0015, Japan
    J Gastroenterol 39:319-23. 2004
    Although cholecystokinin (CCK) has been shown to inhibit gastric emptying via CCK-A receptors (CCK-ARs), the role of CCK-B receptors (CCK-BRs) has not been verified...
  43. ncbi The biology of cholecystokinin and gastrin peptides
    Jens F Rehfeld
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Curr Top Med Chem 7:1154-65. 2007
    b>Cholecystokinin (CCK) and gastrin together constitute a family of homologous peptide hormones, which are both physiological ligands for the gastrin/CCK-B receptor, whereas the CCK-A receptor binds only sulfated CCK-peptides...
  44. ncbi Role of cholecystokinin in the development and progression of acute pancreatitis and the potential of therapeutic application of cholecystokinin receptor antagonists
    C Niederau
    St Josef Hospital, Academic Teaching Hospital, Department of Internal Medicine, Oberhausen, Germany
    Digestion 60:69-74. 1999
    This presentation reviews the role of cholecystokinin (CCK) as a contributory factor for the development and progression of acute pancreatitis (AP) and the perspective of CCK receptor antagonists for treatment of AP...
  45. ncbi Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR 27897 and agonist SR 146131 binding
    P Gouldson
    Sanofi Synthelabo, Centre de Labège, Labège Innopole Voie No 1, BP 137, 31676 Labège Cedex, France
    Eur J Pharmacol 383:339-46. 1999
    A new highly specific, potent non-peptide agonist for the cholecystokinin subtype 1 receptor (CCK(1)), SR 146131 (2-[4-(4-chloro-2, 5-dimethoxyphenyl)-5-(2-cyclohexyl-ethyl)-thiazol-2-ylcarbamoyl ]-5, 7-dimethyl-indol-1-yl-1-acetic acid) ..
  46. ncbi Radiolabeling approaches for cholecystokinin B receptor imaging
    L Aloj
    Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
    Biopolymers 66:370-80. 2002
    ..In particular, cholecystokinin (CCK) receptors of the subtype B (CCK-BR) have been shown to be overexpressed in certain neuroendocrine ..
  47. doi Cholecystokinin-58 is more potent in inhibiting food intake than cholecystokinin-8 in rats
    Joerg Glatzle
    Department of General and Transplantation Surgery, University Hospital, University of Tubingen, Germany
    Nutr Neurosci 11:69-74. 2008
    Several cholecystokinin (CCK) forms have been detected in plasma, but most studies on food intake investigated the effects of CCK-8 only. Recently, it has been demonstrated that CCK-58 is the only endocrine-active form of CCK in rats.
  48. ncbi Stimulation of growth of azaserine-induced putative preneoplastic lesions in rat pancreas is mediated specifically by way of cholecystokinin-A receptors
    S P Povoski
    Department of Surgery, University of Cincinnati College of Medicine, Ohio 45267
    Cancer Res 53:3925-9. 1993
    b>Cholecystokinin (CCK) has been shown to stimulate the growth of both normal pancreas and azaserine-induced putative preneoplastic pancreatic lesions in the rat...
  49. ncbi CCK-B receptor antagonist YF476 inhibits pancreatic enzyme secretion at a duodenal level in pigs
    L Evilevitch
    Department of Cell and Organism Biology, Lund University, Helgonavagen 3B, SE 223 62 Lund, Sweden
    Scand J Gastroenterol 39:886-90. 2004
    To evaluate the mechanisms by which cholecystokinin (CCK) regulates the exocrine pancreas, the role and location of CCK receptors in the pig were investigated using the CCK-B receptor antagonist YF476 and different administration routes ..
  50. doi Disruption of seasonality in growth hormone-transgenic coho salmon (Oncorhynchus kisutch) and the role of cholecystokinin in seasonal feeding behavior
    Mare Lõhmus
    Fisheries and Oceans Canada, Centre for Aquaculture and Environmental Research, 4160 Marine Drive, West Vancouver, V7V 1N6, BC Canada
    Horm Behav 54:506-13. 2008
    ..This reduction may in part be explained by altered production of cholecystokinin (CCK) and growth hormone (GH)...
  51. ncbi Cholecystokinin B-type receptors mediate a G-protein-dependent depolarizing action of sulphated cholecystokinin ocatapeptide (CCK-8s) on rodent neonatal spinal ventral horn neurons
    Murat Oz
    Integrative Neuroscience Section National Institute of Drug Abuse, National Institutes of Health Department of Health and Human Services, Intramural Research Program, Baltimore, MD 21224, USA
    J Neurophysiol 98:1108-14. 2007
    Reports of cholecystokinin (CCK) binding and expression of CCK receptors in neonatal rodent spinal cord suggest that CCK may influence neuronal excitability...
  52. pmc Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi
    J W Wiley
    University of Michigan Medical Center, Department of Internal Medicine, Ann Arbor 48109
    J Clin Invest 81:1920-4. 1988
    This study evaluates the hypothesis that cholecystokinin (CCK) relaxes the sphincter of Oddi via vasoactive intestinal polypeptide (VIP). Isolated canine sphincter of Oddi were suspended in organ baths under standard conditions...
  53. pmc PEGylated cholecystokinin prolongs satiation in rats: dose dependency and receptor involvement
    I Verbaeys
    Interdisciplinary Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium
    Br J Pharmacol 152:396-403. 2007
    Acute intraperitoneal (i.p.) administration of cholecystokinin (CCK) is known to induce a significant, but short-lasting, reduction in food intake, followed by recovery within hours...
  54. pmc Cholecystokinin as a factor in the enhanced potency of spinal morphine following carrageenin inflammation
    L C Stanfa
    Department of Pharmacology, University College London
    Br J Pharmacol 108:967-73. 1993
    1. Cholecystokinin (CCK) has been shown to diminish opioid analgesia...
  55. ncbi A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini
    C Schafer
    Department of Physiology and Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    J Biol Chem 273:24173-80. 1998
    b>Cholecystokinin (CCK) and other pancreatic secretagogues have recently been shown to activate signaling kinase cascades in pancreatic acinar cells, leading to the activation of extracellular signal-regulated kinases and Jun N-terminal ..
  56. ncbi Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled study
    P Zwanzger
    Department of Psychiatry, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuropsychopharmacology 28:979-84. 2003
    b>Cholecystokinin-tetrapeptide (CCK-4) induces panic attacks both in patients with panic disorder (PD) and healthy volunteers. It has been shown that panic elicited by CCK-4 is improved after treatment with antidepressants...
  57. doi Dose-related effects of cholecystokinin octapeptide administered during various phases of the migrating motor complex on small-intestinal motility in sheep
    Krzysztof W Romański
    Department of Animal Physiology, Veterinary School, Wroclaw University of Environmental and Life Sciences, Norwida 31, PL 50 375 Wrocław, Poland
    Acta Vet Hung 57:495-508. 2009
    b>Cholecystokinin (CCK) may affect intestinal motility, but in ruminants its precise effects have not been entirely explored...
  58. pmc Effects of cholecystokinin in the supraoptic nucleus and paraventricular nucleus are negatively modulated by leptin in 24-h fasted lean male rats
    C Caquineau
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Neuroendocrinol 22:446-52. 2010
    b>Cholecystokinin (CCK) and leptin are two important satiety factors that are considered to act in synergy to reduce meal size...
  59. ncbi Ca2+-independent phospholipase A2 contributes to the insulinotropic action of cholecystokinin-8 in rat islets: dissociation from the mechanism of carbachol
    E Simonsson
    Department of Medicine, Lund University, Malmo, Sweden
    Diabetes 47:1436-43. 1998
    Insulin secretion induced by cholecystokinin-8 (CCK-8) was recently suggested to involve phospholipase A2 (PLA2) activation...
  60. pmc The cholecystokinin analogues JMV-180 and CCK-8 stimulate phospholipase C through the same binding site of CCK(A) receptor in rat pancreatic acini
    E Sarri
    Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, 08193 Bellatarra, Barcelona, Spain
    Br J Pharmacol 133:1227-34. 2001
    ..to the involvement of phospholipase C in the signalling pathway linked to CCK(A) receptor stimulation by the cholecystokinin analogue JMV-180, a full agonist for amylase release, in rat pancreatic acini. 2...
  61. ncbi Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy
    M Pellegrini
    Department of Molecular Pharmacology, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    Biochemistry 38:14775-83. 1999
    The bimolecular complex of the C-terminal octapeptide of cholecystokinin, CCK-8, with the N-terminus of the CCK(A)-receptor, CCK(A)-R(1-47), has been structurally characterized by high-resolution NMR and computational refinement...
  62. ncbi Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients
    J W Konturek
    Dept of Medicine B, University of Munster, Germany
    Scand J Gastroenterol 36:241-6. 2001
    Increased gastric emptying and defective action of endogenous cholecystokinin (CCK), that is known to inhibit this emptying, have been implicated in the pathogenesis of duodenal ulcer (DU)...
  63. ncbi Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats
    Daisuke Kanemitsu
    Graduate School of Medical Science, Molecular Gastroenterology, and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Pancreas 32:190-6. 2006
    Prior studies have indicated that endogenous or exogenous cholecystokinin (CCK) induces transient acinar cell proliferation at about 24 hours after its stimulation...
  64. pmc Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor
    Yu Wang
    Department of Medicine, Duke University, Durham Veterans Affairs Medical Centers, Durham, North Carolina, USA
    Am J Physiol Gastrointest Liver Physiol 300:G528-37. 2011
    b>Cholecystokinin (CCK) is produced by discrete endocrine cells in the proximal small intestine and is released following the ingestion of food...
  65. ncbi Genetic inactivation of prohormone convertase (PC1) causes a reduction in cholecystokinin (CCK) levels in the hippocampus, amygdala, pons and medulla in mouse brain that correlates with the degree of colocalization of PC1 and CCK mRNA in these structures
    B M Cain
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Neurochem 89:307-13. 2004
    Prohormone convertase (PC1) is found in endocrine cell lines that express cholecystokinin (CCK) mRNA and process pro CCK to biologically active products...
  66. ncbi Interaction of islet hormones with cholecystokinin octapeptide-evoked secretory responses in the isolated pancreas of normal and diabetic rats
    J Singh
    Department of Applied Biology, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK
    Exp Physiol 84:299-318. 1999
    ..investigates the effects of the islet hormones, insulin (Ins), glucagon (Glu) and somatostatin (Som) with cholecystokinin octapeptide (CCK-8) on amylase secretion and intracellular free calcium concentration [Ca2+]i and their ..
  67. ncbi The method of administration of cholecystokinin determines the effects evoked in the pancreas
    B Ohlsson
    Department of Surgery, University of Lund, Sweden
    Pancreas 23:94-101. 2001
    Earlier studies have shown different effects on cell proliferation and weight characteristics by sulfated cholecystokinin-8 (CCK-8S) in the rat pancreas when the peptide has been administered continuously rather than intermittently...
  68. ncbi Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety
    C Belzung
    Laboratoire d Ethologie et de Pharmacologie du Comportement, UFR Sciences et Techniques, Tours, France
    Behav Pharmacol 8:541-8. 1997
    ..Because of its chronicity, this paradigm may model generalized anxiety, a pathology that has been suggested to overlap trait anxiety...
  69. ncbi [Selected forms of health in the Polish Kingdom and Galicia during the First World War]
    E Wieckowska
    ,
    Przegl Lek 55:724-6. 1998
    ..Despite some elements of social medical care put into practice by CCK at that time, one must admit that the system was bearing traces of alms and charity (CBC)...
  70. ncbi Effect of synthetic porcine neuropeptide Y (NPY) on splanchnic blood flows and exocrine pancreatic secretion in dogs
    S Sumi
    First Department of Surgery, Faculty of Medicine, Kyoto University, Japan
    Dig Dis Sci 36:1523-8. 1991
    ....
  71. ncbi Effect of leptin on insulin, glugacon and somatostatin secretion in the perfused rat pancreas
    R A Silvestre
    , , Spain
    Horm Metab Res 33:207-12. 2001
    ..Leptin inhibition of carbachol-induced insulin output might reflect a restraining effect of this peptide on the cholinergic stimulation of insulin release...
  72. ncbi Gastrin/CCK-like immunoreactivity in Hatschek's groove of Branchiostoma lanceolatum (Cephalochordata)
    K Sahlin
    Department of Zoology, University of Stockholm, Sweden
    Gen Comp Endocrinol 70:436-41. 1988
    ..The function of the gastrin/CCK-like peptide found in Hatschek's groove is discussed...
  73. ncbi Reorganization of neural peptidergic systems in the median eminence after hypophysectomy
    M J Villar
    Department of Neuroscience, Berzelius Laboratory, Karolinska Institutet, Stockholm, Sweden
    J Neurosci 14:5996-6012. 1994
    ..Galanin (GAL)- and cholecystokinin (CCK)-IR fibers exhibited a similar pattern of distribution after the lesion...
  74. ncbi Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight
    H T Bergen
    Department of Anatomy, University of Manitoba, Winnipeg, Canada
    Brain Res 734:332-6. 1996
    ..obesity, and the effects on feeding of peripheral injection of saline, glucose, 2-deoxyglucose (2-DG), or cholecystokinin (CCK) were measured...
  75. pmc Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma
    D S Weinberg
    Division of Gastroenterology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Clin Invest 100:597-603. 1997
    b>Cholecystokinin (CCK) plays an important role in pancreatic carcinogenesis. While human CCK-A and -B receptors have been fully characterized, their relative roles in human pancreatic adenocarcinoma remain unclear...
  76. ncbi Altered processing of procholecystokinin in carboxypeptidase E-deficient fat mice: differential synthesis in neurons and endocrine cells
    K A Lacourse
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    FEBS Lett 436:61-6. 1998
    ..Intestinal CCK synthesis more closely resembles progastrin processing, suggesting the presence of an endocrine-specific biosynthetic regulatory mechanism not present in neurons...
  77. ncbi Cholecystokinin/opioid interactions
    Z Wiesenfeld-Hallin
    Karolinska Institutet, Department of Medical Laboratory Sciences and Technology, Division of Clinical Neurophysiology, Huddinge University Hospital, S 141 86, Huddinge, Sweden
    Brain Res 848:78-89. 1999
    b>Cholecystokinin (CCK) acts as an anti-opioid peptide. The mechanisms of CCK-opioid interaction under normal and pathological conditions were examined with various techniques...
  78. ncbi 2,7-Dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1,4]diazonine as a new template for the design of CCK(2) receptor antagonists
    I M McDonald
    James Black Foundation, 68 Half Moon Lane, Dulwich, London SE24 9JE, U K
    J Med Chem 43:3518-29. 2000
    ..99 +/- 0.05). Compound 32 was 100-fold selective for CCK(2) over CCK(1) receptors based on the affinity estimate obtained in a guinea pig pancreas radioligand binding assay (pK(i) = 5.0)...
  79. ncbi No association or linkage between polymorphisms in the genes encoding cholecystokinin and the cholecystokinin B receptor and panic disorder
    S P Hamilton
    Department of Psychiatry, College of Physicians and Surgeons at Columbia University and the New York State Psychiatric Institute, USA
    Mol Psychiatry 6:59-65. 2001
    Growing animal data implicate cholecystokinin in the regulation of anxiety, while human clinical research confirms the role of cholecystokinin in the provocation of panic attacks...
  80. ncbi Quantitative structure-activity relationship studies on cholecystokinin antagonists
    Satya P Gupta
    Department of Chemistry, Birla Institute of Technology and Science, Pilani, India
    Curr Pharm Des 8:111-24. 2002
    A review is presented on quantitative structure-activity relationship (QSAR) studies on cholecystokinin antagonists. Cholecystokinin (CCK) is a gastrointestinal peptide hormone closely related chemically to gastrin...
  81. ncbi Pharmacological characterization of cholecystokinin receptors mediating contraction of human gallbladder and ascending colon
    M F Morton
    Academic Department of Surgery, Rayne Institute, GKT Schools of Medicine and Dentistry, London SE5 9NU, UK
    Regul Pept 105:59-64. 2002
    b>Cholecystokinin (CCK) produces contractions of gallbladder and colon in a number of different species...
  82. ncbi Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats
    David Feifel
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neurosci Lett 348:147-50. 2003
    The gut-brain peptide cholecystokinin (CCK) has been implicated in the regulation of dopamine (DA) transmission in the brain...
  83. ncbi Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice
    Duan Chen
    Department of Cancer Research and Molecular Medicine, Norweigian University of Science and Technology, Trondheim, Norway
    Gastroenterology 126:476-87. 2004
    ..acid secretion: the gastrin-enterochromaffin-like (ECL) cell axis, the vagus-parietal cell axis, and the cholecystokinin (CCK)-D cell axis...
  84. ncbi Cholecystokinin mRNA in Atlantic herring, Clupea harengus--molecular cloning, characterization, and distribution in the digestive tract during the early life stages
    Yuko Kamisaka
    Department of Biology, University of Bergen, Allegt 41, N 5007 Bergen, Norway
    Peptides 26:385-93. 2005
    The mRNA of the peptide hormone cholecystokinin (CCK) was isolated from juvenile Atlantic herring, Clupea harengus, by RT-PCR. The open reading frame encodes a 137 amino acid-long precursor protein...
  85. ncbi Endocrinology of milk production
    K Svennersten-Sjaunja
    Department of Animal Nutrition and Management, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, 753 23 Uppsala, Sweden
    Domest Anim Endocrinol 29:241-58. 2005
    ..The question has been raised whether the mammary gland is a supporting or consuming organ...
  86. ncbi Lack of trophic pancreatic effects in humans with long-term administration of ximelagatran
    Rodger A Liddle
    Department of Medicine, Duke University, Durham VA Medical Centers, Durham, NC, USA
    Pancreas 32:205-10. 2006
    ..Its mechanism involves the inhibition of intraluminal proteases, resulting in sustained elevation of plasma cholecystokinin (CCK) concentrations, producing a chronic trophic stimulus to the pancreas that leads to the formation of ..
  87. pmc Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice
    Stephen J Crozier
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Physiol 573:775-86. 2006
    b>Cholecystokinin (CCK)-induced pancreatic growth in mice involves parallel increases in DNA and protein...
  88. ncbi Exocrine pancreatic insufficiency in the Eurasian dog breed--inheritance and exclusion of two candidate genes
    H F Proschowsky
    Department of Animal and Veterinary Basic Sciences, Division of Genetics and Bioinformatics, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Anim Genet 38:171-3. 2007
    ..Based on our results, we excluded the canine orthologs of the human cholecystokinin (CCK) and the cholecystokinin A receptor (CCKAR) genes as candidates for exocrine pancreatic insufficiency.
  89. ncbi Association between CCK-AR gene and schizophrenia with auditory hallucinations
    Ivette Toirac
    Department of Genetics, University of Valencia, 46100, Burjassot, Valencia, Spain
    Psychiatr Genet 17:47-53. 2007
    ..The aim of the present study was to assess a potential association between schizophrenic patients with auditory hallucinations and polymorphisms of the CCK-AR gene...
  90. ncbi Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women
    S Naessén
    Department of Woman and Child Health, Division of Obstetrics and Gynecology, Karolinska Institute, Stockholm, Sweden
    Psychoneuroendocrinology 32:548-54. 2007
    ..Basal and meal-related appetite and secretions of the satiety peptide cholecystokinin (CCK) and the appetite-stimulating peptide ghrelin were studied before and after 3 months of treatment with ..
  91. ncbi Targeting of a CCK(2) receptor splice variant with (111)In-labelled cholecystokinin-8 (CCK8) and (111)In-labelled minigastrin
    Peter Laverman
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Eur J Nucl Med Mol Imaging 35:386-92. 2008
    Radiolabelled cholecystokinin (CCK) and gastrin-derived peptides potentially can be used for peptide receptor radionuclide therapy (PRRT). Recently, a splice variant version of the CCK2R has been identified, designated CCK2i4svR...
  92. ncbi Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands
    Shuzhen Hao
    Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 294:R33-8. 2008
    ..Activation of T2Rs increases cholecystokinin (CCK) release from the enteroendocrine cell line, STC-1...
  93. ncbi [Effect of the administration of cholecystokinin on the cholestasis associated with total parenteral nutrition in experimental short bowel]
    N García-Urkia
    Unidad Experimental, Hospital Donostia, San Sebastian
    Cir Pediatr 20:180-2. 2007
    ..cholestasis; the cause of this complication is unclear but it may be due to a lack of an enteral stimulus for cholecystokinin (CCK) production...
  94. doi Dietary restraint and menstrual cycle phase modulated L-phenylalanine-induced satiety
    Rachael J Pohle-Krauza
    Department of Nutrition and Exercise Science, School of Public Health and Health Professions, State University of New York at Buffalo, 15 Farber Hall, Buffalo, NY 14214 8001, USA
    Physiol Behav 93:851-61. 2008
    l-phenylalanine (Phe) has been shown to elicit release of the gut hormone cholecystokinin (CCK) and reduce energy intake. Furthermore, studies in some animal models demonstrate potentiation of CCK-induced satiety by estradiol (E(2))...
  95. doi Gastric emptying in response to IAPP and CCK in rats with subdiaphragmatic afferent vagotomy
    Johan Wickbom
    Department of Clinical Science, Intervention and Technology CLINTEC, Division of Surgery, K53, Karolinska University Hospital, Huddinge, S 14186 Stockholm, Sweden
    Regul Pept 148:21-5. 2008
    ..studied the effect of SDA on the inhibition of GE by islet amyloid polypeptide (IAPP or amylin) and cholecystokinin (CCK) in awake, unrestrained rats with gastric cannulas...
  96. pmc Mechanisms of action of CCK to activate central vagal afferent terminals
    Richard C Rogers
    Laboratory of Autonomic Neurosciences, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Peptides 29:1716-25. 2008
    b>Cholecystokinin [CCK] is a peptide released as a hormone by the proximal gut in response to the presence of peptones and fatty acid in the gut...
  97. doi The effects of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats
    Jeffrey Burgdorf
    Department of Biomedical Engineering, Falk Center for Molecular Therapeutics, Northwestern University, 1801 Maple Ave, Suite 4300, Evanston, IL 60201, USA
    Dev Psychobiol 51:34-46. 2009
    ..We also observed that low line rats have elevated brain levels of cholecystokinin (CCK) in the cortex, which is consistent with literature showing that CCK content in the cortex is positively ..
  98. doi Enterostatin reduces serum cholesterol levels by way of a CCK(1) receptor-dependent mechanism
    Yasuyuki Takenaka
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto 611 0011, Japan
    Peptides 29:2175-8. 2008
    ..The hypocholesterolemic effect of APGPR was inhibited by pretreatment with lorglumide, an antagonist for cholecystokinin 1 (CCK(1)) receptor, even though APGPR does not have any affinity for CCK(1) receptors...
  99. doi Gut peptides in the control of food intake
    T H Moran
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    Int J Obes (Lond) 33:S7-10. 2009
    ..Consistent with this pattern, ghrelin has been shown to stimulate food intake by hastening meal initiations. Cholecystokinin (CCK) is released from upper intestinal sites in response to food intake...
  100. ncbi [Inhibitory effect of Tanreqing injection on proliferation of T lymphoblastic leukemia cell line Molt4 in vitro and its mechanism]
    Bo Yang
    Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 19:44-9. 2011
    ..These biological effects of Tanreqing injection are partly related to cell reduction in S phase, downregulation of bcl-2 gene and upregulation of caspase 3...
  101. pmc Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms
    Jingchuan Zhang
    Programs in Neuroscience and Dept of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 302:R264-73. 2012
    ..We also measured sucrose intake during intravenous infusion of cholecystokinin, a peptide known to reduce food intake via abdominal vagal afferents...

Research Grants65

  1. CCK MODULATION OF ANXIETY AND THE HPA AXIS
    James Abelson; Fiscal Year: 1999
    b>Cholecystokinin (CCK) is the most abundant peptide neurotransmitter in the brain and its known distribution, interactions, and functions make it of great interest to psychiatry, but it has been little studied in humans...
  2. CHOLECYSTOKININ IN PATHOGENESIS OF HUMAN PANCREATIC ADCA
    David Weinberg; Fiscal Year: 1999
    ..There is growing animal and human evidence to suggest an important role for the gastrointestinal hormone, cholecystokinin (CCK), in the pathogenesis of this disease...
  3. Gail L Matters; Fiscal Year: 2016
    ..We have identified a membrane bound growth receptor in human pancreatic cancer cells called the cholecystokinin or CCK- receptor...
  4. CHOLECYSTOKININ MECHANISMS IN CONTROL OF FOOD INTAKE
    ROGER REIDELBERGER; Fiscal Year: 2001
    ..b>Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gut...
  5. Laurence J Miller; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The cholecystokinin (CCK) receptor is a family A peptide-binding G protein-coupled receptor that has multiple important physiologic functions supporting nutritional homeostasis, including the ..
  6. Type A CCK Receptor Structure Function and Regulation
    Laurence J Miller; Fiscal Year: 2010
    this This proposal to examine the molecular basis of cholecystokinin (CCK) receptor structure, function, and regulation supports the long-term goal of understanding the roles of this gastrointestinal hormone in health and disease...
  7. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..The aim of this proposal is to establish a role for cholecystokinin (CCK) in mediating changes in motility and emptying in response to duodenal stimulation, and investigate its ..
  8. PHYSIOLOGY AND PATHOPHYSIOLOGY--SECRETIN, CHOLECYSTOKINI
    William Chey; Fiscal Year: 1999
    The objective of this proposal is to study the mechanisms of secretion and action of secretin (S) and cholecystokinin (CCK)...
  9. CHOLECYSTOKININ EFFECT ON PANCREATIC GROWTH & TUMORS
    Thomas Adrian; Fiscal Year: 1992
    ..that the pancreatic growth in response to feeding raw soya in the rat is accompanied by a rise in plasma cholecystokinin (CCK). Infusion of CCK at a dose which mimics this response causes similar pancreatic growth...
  10. STRUCTURE AND FUNCTION OF CHOLECYSTOKININ RECEPTORS
    Steven Rosenzweig; Fiscal Year: 1991
    The long-range objective of this proposal is to characterize the structural and functional properties of the cholecystokinin receptor on pancreatic acinar cells and retinal neuronal cells...
  11. MOLECULAR ANALYSIS OF THE CHOLECYSTOKININ RECEPTOR
    Craig Logsdon; Fiscal Year: 1993
    b>Cholecystokinin (CCK) is an important gastrointestinal and neural polypeptide with a diverse spectrum of biological activity, however, many basic questions remain about the structure and function of CCK receptors...
  12. EFFECTS OF CHOLECYSTOKININ ON HUMAN PANCREATIC CANCER
    Jill Smith; Fiscal Year: 1993
    ..The central hypothesis of this proposal is that the gastrointestinal hormone, cholecystokinin (CCK), which is trophic for normal pancreatic tissue in animal models is also trophic for pancreatic cancer...
  13. STRUCTURE/FUNCTION OF THE CCK-B/GASTRIN RECEPTOR
    Alan Kopin; Fiscal Year: 2004
    The cholecystokinin-B/gastrin receptor (CCK-BR) is a seven transmembrane domain peptide hormone receptor...
  14. CHOLECYSTOKININ AND FEEDING IN ZUCKER OBESE RATS
    Clifton Baile; Fiscal Year: 1980
    ..The effect of cholecystokinin (CCK) and the octapeptide (OP-CCK), a proposed satiety hormone, on feeding behavior was analyzed in Zucker ..
  15. Timothy F Osborne; Fiscal Year: 2016
    ..showed that activation of intestinal T2R signaling leads to an increase in secretion of polypeptide hormones cholecystokinin (CCK) and glucagon-like-peptide-1 (GLP-1) from enteroendocrine cells and two major actions of CCK are to ..
  16. Mallory Bowers; Fiscal Year: 2014
    ..In a separate study in or laboratory, the neuropeptide cholecystokinin (CCK) also seems to be involved in extinction learning, as animals treated with the CCK-B receptor agonist, ..
  17. Food intake and energy metabolism regulated by apo AIV and CCK
    Chunmin C Lo; Fiscal Year: 2013
    Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are gut peptides secreted from the small intestine in response to dietary lipids, and each reduces food intake...
  18. Joseph R Reeve; Fiscal Year: 2014
    ..interdisciplinary proposal is to determine the roles and mechanisms of action of large molecular forms of cholecystokinin (CCK) in prolonging the length of the postprandial intermeal interval (IMI) during normal feeding...
  19. STUDIES IN GASTROINTESTINAL ENDOCRINOLOGY
    Mark R Hellmich; Fiscal Year: 2010
    ..In Project 2, we will continue our studies on the signal mechanisms that regulate intestinal cholecystokinin (CCK) secretion by studies on the recently discovered peptide, apelin...
  20. John A Williams; Fiscal Year: 2015
    ..GTPliganded form) of Rab27B andRap1 on zymogen granules and is it increased by secretagogues such as cholecystokinin (CCK) and acetylcholine? Is Rap1important for secretion as has been shown for RabSD and 27B? Does Rap1 ..
  21. RECEPTORS FOR CCK AND OTHER GI-HORMONES
    Craig Logsdon; Fiscal Year: 2004
    ..seeks to understand the interactions between pancreatic acinar cells and receptors for bombesin (Bn) and cholecystokinin (CCKA) or gastrin (CCKB)...
  22. Robert C Ritter; Fiscal Year: 2016
    ..NMDAr in the NTS is required for CCK-evoked MAPK signaling and consequent reduction of food intake by cholecystokinin (CCK), the archetypical GI satiation peptide...
  23. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..represent a subpopulation of BLA-interneurons that contain the neuropeptides somatostatin (Sst) and cholecystokinin (Cck), and although these cells appear to be pivotal in the regulation of anxiety-like responses, the ..
  24. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..the influence of these specific neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  25. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..The work will focus on pyramidal cells, PV+ cells, cholecystokinin-expressing (CCK+) cells and somatostatin-containing (SOM+) interneurons...
  26. Helen E Raybould; Fiscal Year: 2016
    ....
  27. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..determine the influence of these neuropeptides (vasoactive intestinal peptide (VIP), substance P (SP), and cholecystokinin (CCK)) on synaptic transmission in thalamocortical circuits...
  28. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Prior evidence shows that GABAergic interneurons in the hippocampus that co-express the neuropeptide cholecystokinin (CCK+ interneurons), also highly express cholinergic receptors, can release endocannabinoids, and may be ..
  29. Rodger A Liddle; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Cholecystokinin (CCK) is a major gastrointestinal hormone that is produced by discrete enteroendocrine cells (known as I cells) that are scattered throughout the intestine...
  30. Brainstem LepRb neurons in the control of metabolism
    JONATHAN NICHOLAS FLAK; Fiscal Year: 2013
    ..We found that many PAG/lPBN LepRb neurons contain the neuropeptide, cholecystokinin (CCK), and that the distribution of these LepRbCCK neurons is restricted to the brainstem...
  31. NEURAL SUBSTRATES OF PEPTIDE INDUCED SATIETY
    Robert C Ritter; Fiscal Year: 2012
    ..goal of this work is to define the neural mechanisms through which gastrointestinal hormones, especially cholecystokinin (CCK) and glucagon-related peptide (CCK), control food intake and to appreciate how these substrates are ..
  32. JAMES ERNEST BLEVINS; Fiscal Year: 2015
    ..the behavioral effects and hindbrain neuronal activation produced by meal-related satiety signals, such as cholecystokinin (CCK), are altered in states of diet-induced obesity (DIO)...
  33. NUCLEUS TRACTUS SOLITARIUS MELANOCORTIN SIGNALING IN THE CONTROL OF FOOD INTAKE
    SCOTT EDWARD KANOSKI; Fiscal Year: 2012
    ..MC4-R ligands, and that caudal brainstem MC4-R signaling is required for food intake suppression by exogenous cholecystokinin (CCK), the intestinally-derived satiation hormone...
  34. Rodger A Liddle; Fiscal Year: 2015
    ..b>Cholecystokinin (CCK) is a prototypical gastrointestinal hormone that regulates gallbladder contraction, pancreatic enzyme ..
  35. Suzanne M Appleyard; Fiscal Year: 2016
    ..catecholamines (NTS-CA neurons) disrupts control of food intake by several hormones, including ghrelin and cholecystokinin (CCK)...
  36. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..CBIRs are localized to presynaptic terminals of cholecystokinin-(CCK) expressing basket cells, a class of GABAergic interneurons...
  37. Regulation of Stomach Ghrelin
    GEORGE GREELEY; Fiscal Year: 2009
    ..Aim 2. To test the hypothesis that stomach ghrelin homeostasis is regulated by cholecystokinin (CCK), glucagon and insulin-like growth factor-1 (IGF-I). Aim 3...
  38. Brain integration of adiposity and satiety signals in the control of food intake
    Diana Williams; Fiscal Year: 2009
    ..neural circuitry that integrates input from the adiposity hormone leptin and the gut-derived satiety signals cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), and the physiological relevance of the interactions between these ..
  39. Gregory M Holmes; Fiscal Year: 2015
    ..For example, SCI results in 1) diminished postprandial serum expression of cholecystokinin (CCK);2) diminished NTS activation following peripheral sulfated CCK (CCK-8s);3) diminished gastroinhibition ..
  40. Gil D Hoftman; Fiscal Year: 2014
    ..9-THC), activates cannabinoid 1 receptors (CB1r) that are highly concentrated on the axon terminals of cholecystokinin-expressing basket cells (CB1r/CCK cells) in the primate dorsolateral prefrontal cortex (DLPFC), a region ..
  41. CCK CELL FUNCTION
    Rodger A Liddle; Fiscal Year: 2010
    b>Cholecystokinin (CCK) is produced by discrete enteric endocrine cells (I cells) of the proximal small intestine and secreted into the blood upon ingestion of food. However, the exact nature by which the CCK cell is regulated is unknown...
  42. Brain integration of adiposity and satiety signals in the control of food intake
    Diana L Williams; Fiscal Year: 2011
    ..neural circuitry that Integrates input from the adiposity hormone leptin and the gut-derived satiety signals cholecystokinin (CCK) and glucagon-like peptlde-1 (GLP-1), and the physiological relevance ofthe interactions between these ..
  43. Cannabis and Adolescent Brain Development
    David A Lewis; Fiscal Year: 2012
    ..In primates, the DLPFC is densely innervated by CB1R-immunoreactive (CB1R-IR) axons that arise from the cholecystokinin (CCK)-containing class of GABA basket neurons and that synapse on the soma of pyramidal neurons...
  44. GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis
    DEEPAK CYRIL D apos SOUZA; Fiscal Year: 2010
    ..CB1 receptors (CB1-Rs) are present on the axon terminals of cholecystokinin (CCK) containing GABA neurons that target pyramidal cells...
  45. Chunmin C Lo; Fiscal Year: 2014
    ..Apolipoprotein AIV (apo AIV) and cholecystokinin (CCK) are each satiating signals secreted from the small intestine in response to dietary lipids, and the ..
  46. Xiangmin Xu; Fiscal Year: 2016
    ..input to the most numerous inhibitory cell types including parvalbumin-expressing (PV+) basket cells, cholecystokinin- expressing (CCK+) basket cells, axo-axonic cells, and somatostatin-expressing (SOM+) oriens-lacunosum ..
  47. SURGICAL STUDIES ON METABOLISM OF G. I. HORMONES
    James Thompson; Fiscal Year: 1993
    ..We plan to characterize cholecystokinin (CCK), NT, bombesin, and peptide YY (PYY) by HPLC...
  48. CALCIUM REGULATION IN ORAL HEALTH
    Rodrigo S Lacruz; Fiscal Year: 2013
    ..Recent work by the PI indicates that Stim1, Orai1 as well as well as the Ca2+ signaling cholecystokinin (Cck) and the Cck inhibitor Rcan1 were identified as being significantly up-regulated in maturation...
  49. CNS CCK IN APPETITIVE AND CONSUMMATORY FOOD MOTIVATION
    ELIOT STELLAR; Fiscal Year: 1991
    The purpose of the proposed studies is to determine the behavioral and biological bases of the effects of cholecystokinin octapeptide (CCK-8) on the rat's responses to food...
  50. ACUTE AND CHRONIC COCAINE-INDUCED CCK RELEASE
    Margery Beinfeld; Fiscal Year: 2001
    ..b>Cholecystokinin (CCK) is co-localized with dopamine in this system...
  51. NUTRIENT INDUCED GASTRIC PROTECTION--ROLE OF CCK
    David Mercer; Fiscal Year: 2000
    b>Cholecystokinin (CCK) is a gut peptide produced by CCK cells located in the duodenum and proximal jejunum. The major dietary intestinal stimuli for its release are intact proteins and fatty acids...
  52. Mixed Opioid Agonists / Cholecystokinin Antagonists for Treatment of Pain
    Edward Roberts; Fiscal Year: 2011
    ..One prominent neuropeptide that shows enhanced expression in these abnormal pain states is cholecystokinin (CCK)...
  53. REGULATION OF PANCREATIC EXOCRINE FUNCTION BY MANAGANESE
    Murray Korc; Fiscal Year: 1991
    ..Mn also enhances pancreatic digestive enzyme release. Cholecystokinin (CCK), a pancreatic secretagogue that mobilizes intracellular Ca2+ by activating the phosphatidylinositol ..
  54. ISOLATION OF VERTEBRATE NEURAL CHOLESCYSTOKININ HOMOLOGS
    Ruthann Nichols; Fiscal Year: 1992
    b>Cholecystokinin (CCK) and gastrin are members of a family of neuralgastrointestinal peptides. CCK is one of the most abundant vertebrate brain peptides. However, no neural function(s) has been elucidated for CCK...
  55. THE INFLAMMATORY RESPONSE OF THE PANCREATIC ACINAR CELL
    Stephen Pandol; Fiscal Year: 2006
    ..We have preliminary data showing that the key agonist for pancreatic acinar cells, the hormone cholecystokinin (CCK), causes activation of intracellular signals (i.e...
  56. SATIETY EFFECT OF CHOLECYSTOKININ
    Gerard Smith; Fiscal Year: 2000
    Recent evidence from our laboratory and others has proven our 1973 hypothesis that cholecystokinin (CCK) released from the small intestine by the preabsorptive stimuli of ingested food is part of the negative feedback, satiating ..
  57. RVM CCK and Neuropathic Pain
    Josephine Lai; Fiscal Year: 2007
    ..In this regard, the proposed experiments may reveal an important role for CCK receptor antagonists as therapy for neuropathic pain. ..
  58. DEVELOPMENT OF UNIFIED MODELS OF CCK RECEPTOR SUBTYPE
    Gregory Nikiforovich; Fiscal Year: 1999
    ..We will synthesize the designed compounds and will submit them for biological studies in vitro as well as in cell test systems with cloned and expressed mutants and chimeric CCK receptors. ..
  59. Gail L Matters; Fiscal Year: 2014
    ..The role of CCK-B targeted aptamers on apoptosis will also be investigated. The long term goal of our research is to improve treatment and survival of patients with pancreatic cancer. ..
  60. TIMOTHY CRAGIN WANG; Fiscal Year: 2016
    ....
  61. BIFUNCTIONAL OPIOID/CCK LIGANDS FOR PAIN
    Frank Porreca; Fiscal Year: 2006
    ..This novel mechanism of action should yield therapeutic utility as well as provide an increased understanding of opioid-CCK interactions in normal and pathological pain states. ..
  62. The Role of Glutamate and CCK in the PBN in Taste Reactivity
    Michael King; Fiscal Year: 2007
    ..b>Cholecystokinin (CCK) is a gut peptide that has satiety effects...
  63. The Cholecystokinin-C (CCK-C) Receptor for Early Detection of Pancreatic Cancer
    Jill P Smith; Fiscal Year: 2010
    ..These studies are part of the applicant's long- term goals to understand the mechanisms controlling growth of pancreatic cancer and to diagnose patients in early stage of disease to improve long-term survival. ..
  64. Studies of a Novel CCK-B/Gastrin Receptor Splice Variant
    MARK HELLMICH; Fiscal Year: 2005
    ..The investigators have identified and isolated the cDNA for a novel splice variant of the human cholecystokinin-B/gastrin receptor (CCK-BR), a member of the G protein-coupled receptor (GPCR) superfamily...